Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP

Name: Work Video:
Duration: 3 min 30 s
Chen Zhu; K. LAKSHMI RAO; Huabao Xiong; Khatuna Gagnidze; Fengling Li; Curt M. Horvath; Scott E. Plevy
{'id': 'https://openalex.org/W2001617137', 'doi': 'https://doi.org/10.1074/jbc.m306441200', 'title': 'Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP', 'display_name': 'Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP', 'publication_year': 2003, 'publication_date': '2003-10-01', 'ids': {'openalex': 'https://openalex.org/W2001617137', 'doi': 'https://doi.org/10.1074/jbc.m306441200', 'mag': '2001617137', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12876285'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m306441200', 'pdf_url': 'http://www.jbc.org/article/S0021925820829780/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820829780/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034311245', 'display_name': 'Chen Zhu', 'orcid': 'https://orcid.org/0000-0001-5302-1233'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chen Zhu', 'raw_affiliation_strings': ['Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA'], 'affiliations': [{'raw_affiliation_string': 'Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110097901', 'display_name': 'K. LAKSHMI RAO', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kavitha Rao', 'raw_affiliation_strings': ['Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110443604', 'display_name': 'Huabao Xiong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Huabao Xiong', 'raw_affiliation_strings': ['Immunobiology Center Mount Sinai School of Medicine New York, New York 10029'], 'affiliations': [{'raw_affiliation_string': 'Immunobiology Center Mount Sinai School of Medicine New York, New York 10029', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064922181', 'display_name': 'Khatuna Gagnidze', 'orcid': 'https://orcid.org/0000-0002-8503-7261'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Khatuna Gagnidze', 'raw_affiliation_strings': ['Immunobiology Center Mount Sinai School of Medicine New York, New York 10029'], 'affiliations': [{'raw_affiliation_string': 'Immunobiology Center Mount Sinai School of Medicine New York, New York 10029', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073439690', 'display_name': 'Fengling Li', 'orcid': 'https://orcid.org/0000-0002-7962-9033'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fengling Li', 'raw_affiliation_strings': ['Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009824810', 'display_name': 'Curt M. Horvath', 'orcid': 'https://orcid.org/0000-0003-2449-225X'}, 'institutions': [{'id': 'https://openalex.org/I98704320', 'display_name': 'Icahn School of Medicine at Mount Sinai', 'ror': 'https://ror.org/04a9tmd77', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I98704320']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Curt Horvath', 'raw_affiliation_strings': ['Immunobiology Center Mount Sinai School of Medicine New York, New York 10029'], 'affiliations': [{'raw_affiliation_string': 'Immunobiology Center Mount Sinai School of Medicine New York, New York 10029', 'institution_ids': ['https://openalex.org/I98704320']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110881723', 'display_name': 'Scott E. Plevy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Scott Plevy', 'raw_affiliation_strings': ['Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261'], 'affiliations': [{'raw_affiliation_string': 'Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261', 'institution_ids': ['https://openalex.org/I170201317']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.316, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 103, 'citation_normalized_percentile': {'value': 0.858257, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '278', 'issue': '41', 'first_page': '39372', 'last_page': '39382'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12620', 'display_name': 'Signaling Pathways in Disease', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nfat', 'display_name': 'NFAT', 'score': 0.94929737}, {'id': 'https://openalex.org/keywords/chromatin-immunoprecipitation', 'display_name': 'Chromatin immunoprecipitation', 'score': 0.7298777}], 'concepts': [{'id': 'https://openalex.org/C189938988', 'wikidata': 'https://www.wikidata.org/wiki/Q24744925', 'display_name': 'NFAT', 'level': 4, 'score': 0.94929737}, {'id': 'https://openalex.org/C134320426', 'wikidata': 'https://www.wikidata.org/wiki/Q901026', 'display_name': 'Chromatin immunoprecipitation', 'level': 5, 'score': 0.7298777}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7254741}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.5316572}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.4630006}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.4083318}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.38220248}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.31868204}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.28466263}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.25658217}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11987743}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.09784827}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m306441200', 'pdf_url': 'http://www.jbc.org/article/S0021925820829780/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m306441200', 'pdf_url': 'http://www.jbc.org/article/S0021925820829780/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1504628996', 'https://openalex.org/W1532157284', 'https://openalex.org/W1534412053', 'https://openalex.org/W1538233951', 'https://openalex.org/W1583222838', 'https://openalex.org/W1585007907', 'https://openalex.org/W1592326302', 'https://openalex.org/W1599692958', 'https://openalex.org/W1833319933', 'https://openalex.org/W1937521341', 'https://openalex.org/W1950580345', 'https://openalex.org/W1963827945', 'https://openalex.org/W1963880868', 'https://openalex.org/W1965694516', 'https://openalex.org/W1977817262', 'https://openalex.org/W1988304711', 'https://openalex.org/W1988393300', 'https://openalex.org/W1991210089', 'https://openalex.org/W2004734553', 'https://openalex.org/W2029275361', 'https://openalex.org/W2034890422', 'https://openalex.org/W2046857027', 'https://openalex.org/W2050126429', 'https://openalex.org/W2056970059', 'https://openalex.org/W2061937637', 'https://openalex.org/W2070910474', 'https://openalex.org/W2074079796', 'https://openalex.org/W2074475161', 'https://openalex.org/W2087905758', 'https://openalex.org/W2089995740', 'https://openalex.org/W2094168446', 'https://openalex.org/W2098586771', 'https://openalex.org/W2101385118', 'https://openalex.org/W2101647368', 'https://openalex.org/W2102204735', 'https://openalex.org/W2104439753', 'https://openalex.org/W2108399976', 'https://openalex.org/W2108473659', 'https://openalex.org/W2120419169', 'https://openalex.org/W2124188187', 'https://openalex.org/W2130933356', 'https://openalex.org/W2131933701', 'https://openalex.org/W2133922377', 'https://openalex.org/W2140707292', 'https://openalex.org/W2142446767', 'https://openalex.org/W2143522905', 'https://openalex.org/W2144206734', 'https://openalex.org/W2154064567', 'https://openalex.org/W2161113731', 'https://openalex.org/W4313331833', 'https://openalex.org/W4313347785'], 'related_works': ['https://openalex.org/W61640353', 'https://openalex.org/W4286613491', 'https://openalex.org/W2520554969', 'https://openalex.org/W2065326632', 'https://openalex.org/W2053021306', 'https://openalex.org/W2040005722', 'https://openalex.org/W2024129730', 'https://openalex.org/W1985365358', 'https://openalex.org/W1974454660', 'https://openalex.org/W1581991494'], 'abstract_inverted_index': {'Interleukin': [0, 214], '(IL)-12': [1, 215], 'is': [2, 7, 57, 104, 107, 127, 137, 181, 209, 216, 221, 271, 318, 321, 341, 351, 395, 423, 487, 526, 539, 561, 621, 631, 651, 700, 747, 956, 1190, 1362, 1416, 1424, 1470, 2146, 2151, 2160, 2171, 2180, 3476, 3571, 4045, 4086, 4103, 4154, 4388], 'a': [3, 13, 95, 217, 227, 309, 488, 618, 632, 804, 989, 999, 1034, 1069, 1250, 1444, 1512, 1548, 1634, 2014, 2020, 2198, 2332, 2575, 3058, 3113, 3322, 3388, 3405, 3417, 3508, 3572, 3950, 3979, 4013, 4088, 4265, 4390, 4467, 4475], 'heterodimeric': [4, 218, 489], 'cytokine': [5, 48, 219, 262, 490, 810, 817, 1366], 'that': [6, 65, 106, 220, 279, 320, 606, 705, 756, 997, 1134, 1349, 1367, 1421, 1447, 2016, 3472, 3706, 3751, 3957, 4040, 4074, 4142, 4162], 'critical': [8, 222], 'for': [9, 110, 139, 193, 223, 324, 353, 407, 958, 1192, 1299, 1426, 1551, 1661, 1725, 2025, 2254, 2416, 2508, 2539, 2608, 2635, 2671, 2685, 2694, 2787, 2852, 2900, 2938, 2955, 2967, 2979, 3103, 3149, 3189, 3294, 3467, 3575, 3693, 3743, 4137, 4414], 'the': [10, 47, 52, 130, 152, 177, 203, 224, 261, 266, 344, 366, 391, 417, 503, 565, 603, 697, 794, 809, 934, 946, 951, 985, 1039, 1063, 1178, 1205, 1210, 1241, 1312, 1317, 1356, 1378, 1411, 1482, 1540, 1575, 1726, 1759, 1766, 1793, 1926, 1932, 1969, 2123, 2127, 2135, 2142, 2165, 2174, 2185, 2261, 2371, 2379, 2413, 2485, 2492, 2524, 2661, 2921, 3000, 3067, 3263, 3303, 3315, 3327, 3333, 3402, 3540, 3585, 3686, 3811, 3841, 3861, 3895, 3985, 3995, 4024, 4048, 4063, 4075, 4127, 4256, 4393, 4403, 4424, 4487, 4502, 4510, 4516], 'development': [11, 225, 815], 'of': [12, 51, 123, 146, 179, 185, 226, 265, 337, 360, 393, 399, 500, 507, 567, 635, 836, 927, 960, 1038, 1062, 1195, 1358, 1375, 1452, 1468, 1500, 1511, 1530, 1554, 2094, 2119, 2141, 2164, 2428, 2467, 2495, 2564, 2569, 2586, 2595, 2602, 2622, 2648, 2820, 2828, 2836, 2986, 2994, 3002, 3115, 3145, 3185, 3194, 3252, 3265, 3268, 3302, 3309, 3332, 3390, 3404, 3450, 3454, 3514, 3584, 3685, 3997, 4026, 4065, 4100, 4220, 4259, 4392, 4402, 4412, 4426, 4515], 'T-helper-1': [14, 228, 508], 'immune': [15, 229, 556], 'response': [16, 230, 469, 620, 1208, 2156], 'and': [17, 31, 41, 80, 117, 125, 148, 162, 174, 199, 207, 231, 245, 255, 294, 331, 339, 362, 376, 388, 413, 421, 494, 505, 530, 535, 546, 574, 583, 625, 639, 746, 753, 816, 819, 830, 995, 1009, 1041, 1059, 1075, 1098, 1145, 1200, 1247, 1431, 1438, 1458, 1490, 1502, 1521, 1536, 1583, 1669, 1672, 1765, 1779, 1785, 1792, 1809, 1820, 1830, 1865, 1941, 1952, 2103, 2107, 2153, 2173, 2197, 2336, 2357, 2412, 2457, 2472, 2479, 2518, 2566, 2597, 2630, 2633, 2645, 2688, 2888, 2934, 2941, 2951, 2962, 3049, 3131, 3140, 3199, 3241, 3278, 3285, 3429, 3452, 3539, 3700, 3823, 3847, 3890, 3930, 3935, 3984, 4008, 4035, 4057, 4096, 4118, 4176, 4178, 4188, 4202, 4223, 4236, 4241, 4253, 4262, 4288, 4293, 4305, 4420, 4434, 4452, 4484, 4499], 'immunity': [18, 232], 'against': [19, 233, 558, 1837, 4173, 4239, 4450], 'intracellular': [20, 234, 751], 'pathogens.': [21, 235], 'The': [22, 236, 497, 648, 1373, 1754, 2139, 2162, 2343, 2381, 2436, 2500, 2588, 2638, 3154, 3171, 3205, 3498, 4098, 4307], 'IL-12': [23, 54, 85, 165, 237, 268, 299, 379, 501, 525, 560, 609, 630, 708, 795, 837, 928, 953, 1043, 1179, 1197, 1211, 1254, 1313, 1370, 1379, 1413, 1506, 1524, 1555, 1562, 2129, 2186, 2320, 2546, 2715, 3305, 3316, 3335, 3408, 3687, 3707, 3746, 3812, 4049, 4076, 4517], 'p40': [24, 55, 86, 111, 153, 166, 238, 269, 300, 325, 367, 380, 638, 698, 796, 935, 954, 987, 1044, 1064, 1180, 1212, 1314, 1371, 1380, 1414, 1507, 1525, 1556, 1563, 2130, 2187, 2321, 2547, 2716, 3306, 3317, 3336, 3409, 3688, 3708, 3747, 3813, 3903, 4050, 4077, 4404, 4518], 'gene': [25, 87, 239, 301, 610, 650, 699, 1508, 1557], 'product,': [26, 240], 'expressed': [27, 241, 653], 'specifically': [28, 242], 'in': [29, 68, 176, 197, 243, 282, 390, 411, 528, 554, 564, 572, 623, 654, 703, 757, 801, 828, 833, 950, 1004, 1046, 1055, 1209, 1240, 1253, 1301, 1410, 1476, 1516, 1621, 1800, 1915, 2027, 2267, 2387, 2431, 2446, 2555, 2592, 2752, 2834, 2911, 2920, 2964, 2999, 3076, 3175, 3243, 3262, 3314, 3401, 3427, 3590, 3717, 3840, 3856, 3866, 3880, 3963, 3989, 4000, 4047, 4068, 4149, 4455, 4460], 'macrophages': [30, 244, 493, 529, 1199, 3591], 'dendritic': [32, 246, 495, 531, 1201], 'cells,': [33, 202, 247, 416, 2913, 3810], 'heterodimerizes': [34, 42, 248, 256], 'with': [35, 43, 249, 257, 803, 1803, 1937, 2013, 2101, 2109, 2132, 2418, 2425, 2491, 2515, 2530, 2542, 2561, 2599, 2617, 2643, 2680, 2690, 2825, 2863, 2890, 2907, 2931, 2947, 2991, 3015, 3021, 3070, 3089, 3098, 3121, 3191, 3209, 3249, 3275, 3296, 3698, 3833, 3869, 3910, 3959, 3973], 'p35': [36, 250, 649], 'to': [37, 45, 102, 142, 251, 259, 316, 356, 551, 608, 807, 823, 942, 945, 1104, 1310, 1408, 1449, 1456, 1461, 1534, 1567, 1571, 1574, 1964, 2023, 2134, 2325, 2338, 2349, 2355, 2362, 2483, 2488, 2613, 2713, 2749, 2830, 3080, 3159, 3300, 3329, 3397, 3413, 3416, 3437, 3444, 3502, 3507, 3545, 3550, 3753, 3817, 3899, 3902, 3955, 4055, 4062, 4082, 4164, 4226, 4315, 4400, 4432, 4493, 4509, 4512, 4522], 'form': [38, 252, 808], 'bioactive': [39, 253, 707, 1196], 'IL-12,': [40, 254], 'p19': [44, 258, 805], 'comprise': [46, 260], 'IL-23.': [49, 263, 811], 'Regulation': [50, 264], 'murine': [53, 267, 952, 1040, 1412, 1561, 1662, 1789, 2128, 2175, 2683, 3304, 3334], 'promoter': [56, 112, 132, 270, 326, 346, 955, 961, 1005, 1141, 1213, 1315, 1381, 1415, 1427, 1484, 1564, 2022, 2131, 2168, 2322, 2364, 3337, 3410, 3441, 3460, 3541, 3689, 3852, 3863, 3904, 4051, 4078, 4166, 4405], 'complex.': [58, 272], 'Multiple': [59, 273, 1050], 'cis-acting': [60, 274, 1137], 'elements': [61, 275, 1052, 1067, 1138, 1352, 4318], 'have': [62, 276, 824, 931, 1587, 2204, 3703, 4439], 'been': [63, 277, 821, 1175, 1588, 2205, 2385], 'characterized': [64, 278], 'are': [66, 89, 191, 280, 303, 405, 502, 642, 1463, 1479, 1494, 2258, 2376, 3588, 3712, 3831, 4486, 4501], 'involved': [67, 281, 563, 1054], 'activation': [69, 113, 283, 327, 1006, 1142, 1428, 1538, 3697, 3826, 3864], 'by': [70, 114, 133, 183, 211, 284, 328, 347, 397, 425, 492, 533, 644, 750, 963, 1007, 1143, 1198, 1429, 1485, 1497, 1626, 1774, 2105, 2329, 2370, 2441, 2537, 2898, 3047, 3138, 3169, 3282, 3287, 3592, 3715, 3821, 3924, 3933, 4111], 'bacterial': [71, 81, 285, 295, 536, 754, 1146], 'products.': [72, 286], 'However,': [73, 287, 1237, 1342, 4120, 4386], 'molecular': [74, 288, 604, 1297], 'mechanisms': [75, 289], 'through': [76, 290, 1316], 'which': [77, 291, 641, 1453, 3570], 'interferon': [78, 292, 472, 1242, 3576], '(IFN)-γ': [79, 293], 'products': [82, 296, 755, 1147], 'synergistically': [83, 150, 297, 364, 1504], 'activate': [84, 298, 1311], 'expression': [88, 302, 611, 1659, 1723, 1757, 1762, 1770, 2572, 2580, 2718, 2923, 2936], 'less': [90, 304, 4104], 'clear.': [91, 305, 4105], 'In': [92, 306, 549, 695, 984, 1399, 2768, 4429, 4496], 'this': [93, 143, 307, 357, 1300, 1346, 1400, 1422, 1450, 1622, 3386, 3473, 3683, 3744, 3881, 4121, 4165, 4229, 4494], 'study,': [94, 308, 1401], 'composite': [96, 310, 4317], 'NFAT/ICSBP': [97, 311], 'binding': [98, 122, 141, 312, 336, 355, 1071, 1441, 1467, 2202, 3519, 3573, 3844, 3943, 3982, 4019, 4043, 4060, 4268, 4395, 4425, 4477], 'site': [99, 313, 939, 949, 1072, 1101, 1636, 2189, 2192, 2345, 2352, 2359, 3520, 3574, 3983, 4020, 4044], 'at': [100, 314, 2462, 2497, 2505, 2605, 2841, 2856, 2976, 3007, 3106, 3112, 3259, 4398], '–68': [101, 315], '–54': [103, 317, 1409, 3398, 3503], 'identified': [105, 319], 'functionally': [108, 322], 'important': [109, 323, 541, 614, 826, 1183, 1364, 1403, 1425], 'lipopolysaccharide': [115, 329], '(LPS)': [116, 330], 'LPS': [118, 332, 964, 1008, 1430, 1535, 1940, 2693, 2764, 3836, 3872, 3934], 'plus': [119, 333, 3835, 3871], 'IFN-γ.': [120, 334, 1432], 'DNA': [121, 180, 335, 394, 1439, 1466, 2097, 2201, 2315, 2525, 3186, 3279, 3291, 3518, 4059, 4267, 4394, 4476], 'NFAT': [124, 136, 147, 158, 173, 189, 206, 338, 350, 361, 372, 387, 403, 420, 1454, 1473, 1489, 1501, 1515, 1729, 2149, 2344, 3311, 3510, 3843, 3981, 4042, 4058, 4182, 4263, 4500], 'ICSBP': [126, 140, 149, 175, 194, 208, 340, 354, 363, 389, 408, 422, 1248, 1307, 1459, 1469, 1491, 1503, 1756, 1854, 2351, 2831, 2935, 4421, 4483, 4520], 'demonstrated': [128, 342, 822, 1249, 1348, 1480, 3321, 3705, 3828], 'on': [129, 343, 933, 1377, 1481, 2970, 3152, 3459], 'endogenous': [131, 164, 186, 345, 378, 400, 1483, 1523], 'chromatin': [134, 348, 1486, 3059, 3161], 'immunoprecipitation.': [135, 349], 'required': [138, 192, 352, 406, 1191], 'region.': [144, 358, 4495], 'Overexpression': [145, 359, 1499], 'activates': [151, 365, 1505], 'promoter.': [154, 368, 936, 3307, 4519], 'A': [155, 169, 369, 383, 1296, 1822, 3094, 3464, 4410], 'dominant': [156, 370, 450, 1513, 1727], 'negative': [157, 371, 451, 1514, 1728], 'molecule': [159, 373], 'attenuates': [160, 374, 1519], 'LPS-': [161, 198, 375, 412, 1520, 3925], 'IFN-γ-activated': [163, 200, 377, 414, 1522, 3927], 'mRNA': [167, 381, 1526, 2548, 2717], 'expression.': [168, 382, 1558], 'physical': [170, 384], 'association': [171, 204, 385, 418], 'between': [172, 205, 386, 419, 543, 1073, 2030], 'absence': [178, 392], 'detected': [182, 396, 702, 1496], 'co-immunoprecipitation': [184, 398], 'proteins.': [187, 401], 'Three': [188, 402], 'domains': [190, 404, 3470], 'interaction.': [195, 409, 1542], 'Finally,': [196, 410, 2708], 'RAW-264.7': [201, 415], 'abrogated': [210, 424], 'IL-10': [212, 426, 1361, 1376, 1528, 1552, 1831, 2771], 'priming.': [213, 427], 'IL': [428], '1The': [429], 'abbreviations': [430], 'used': [431, 2482, 2584, 3111, 3188, 3967, 4136, 4454], 'are:': [432], 'IL,': [433], 'interleukin;': [434], 'LPS,': [435, 1814, 3090, 3822], 'lipopolysaccharide;': [436], 'IFN,': [437], 'interferon;': [438], 'Th1,': [439], 'T-helper-1;': [440], 'EMSA,': [441, 2091], 'electrophoretic': [442], 'mobility': [443, 1434], 'shift': [444, 1435], 'assay;': [445], 'CAT,': [446], 'chloramphenicol': [447, 1579], 'acetyltransferase;': [448], 'Dn-NFAT,': [449], 'NFAT;': [452], 'CsA,': [453], 'cyclosporin': [454, 1821, 3093], 'A;': [455], 'hCD4,': [456], 'human': [457, 986, 1042, 1755, 1767, 1794, 2570], 'CD4;': [458], 'PBS,': [459, 2644, 3215], 'phosphate-buffered': [460], 'saline;': [461], 'GST,': [462], 'glutathione': [463], 'S-transferase;': [464], 'CMV,': [465], 'cytomegalovirus;': [466], 'ISRE,': [467], 'interferon-stimulated': [468], 'element;': [470], 'IRF,': [471], 'regulatory': [473, 1243, 3577], 'factor;': [474], 'DMEM,': [475], "Dulbecco's": [476], 'modified': [477], "Eagle's": [478], 'medium;': [479], 'PMA,': [480], 'phorbol': [481, 1815], '12-myristate': [482, 1816], '13-acetate;': [483], 'NF-κB,': [484], 'nuclear': [485, 2062, 2468, 2788, 2821, 3512, 3911, 3928, 4150], 'factor-κB.-12': [486], 'produced': [491], 'cells.': [496, 1049, 1202, 3433], 'key': [498], 'functions': [499, 553], 'induction': [504, 959], 'maintenance': [506], '(Th1)': [509], 'responses': [510, 761], '(1Trinchieri': [511], 'G.': [512, 1014, 1016, 1329, 1391, 2399, 3603, 3781, 3783, 3791], 'Annu.': [513, 3528, 4276], 'Rev.': [514, 3529, 4277], 'Immunol.': [515, 916, 1269, 1333, 1393, 1689, 2403, 3530, 3607, 3658, 3674, 4278, 4334, 4377], '1995;': [516, 978], '13:': [517, 891], '251-276Crossref': [518], 'PubMed': [519, 596, 690, 741, 788, 898, 920, 981, 1025, 1093, 1125, 1167, 1232, 1291, 1337, 1610, 1653, 1717, 1749, 1908, 2005, 2054, 2085, 2224, 2248, 2286, 2310, 2407, 2738, 2813, 3354, 3378, 3493, 3534, 3565, 3611, 3644, 3678, 3737, 3771, 3798, 4282, 4363, 4381], 'Scopus': [520, 597, 691, 742, 789, 899, 921, 1026, 1094, 1126, 1168, 1233, 1292, 1338, 1611, 1654, 1718, 1750, 1909, 2006, 2055, 2086, 2225, 2249, 2287, 2311, 2408, 2739, 2814, 3355, 3379, 3494, 3535, 3566, 3612, 3645, 3679, 3738, 3772, 3799, 4283, 4364, 4382], '(2243)': [521], 'Google': [522, 599, 693, 744, 791, 901, 923, 982, 1028, 1096, 1128, 1170, 1235, 1273, 1294, 1340, 1397, 1613, 1656, 1693, 1720, 1752, 1911, 2008, 2057, 2088, 2227, 2251, 2289, 2313, 2410, 2741, 2816, 3357, 3381, 3496, 3537, 3568, 3614, 3647, 3662, 3681, 3740, 3774, 3801, 4285, 4338, 4366, 4384], 'Scholar).': [523, 600, 694, 792, 924, 983, 1029, 1129, 1171, 1236, 1295, 1341, 1398, 1614, 1657, 1721, 1753, 1912, 2009, 2058, 2089, 2252, 2314, 2742, 2817, 3382, 3497, 3741, 4385], 'As': [524, 2574, 3582, 4255], 'induced': [527, 749, 3589, 3714], 'cells': [532, 704, 1518, 1532, 1877, 1917, 1934, 1970, 2475, 2554, 2616, 2639, 2657, 2668, 2746, 2784, 2928, 3073, 3086, 3720, 3830, 3867, 3916], 'bacteria': [534, 752, 1144], 'products,': [537], 'it': [538], 'an': [540, 825, 1099, 1363, 1402, 2618, 2672, 2695, 3310, 3551, 4017, 4041, 4146, 4179, 4214, 4224], 'bridge': [542], 'host': [544, 555], 'innate': [545], 'adaptive': [547], 'immunity.': [548], 'addition': [550], 'its': [552], 'defense': [557], 'microorganisms,': [559], 'also': [562, 798, 1354, 1495, 2367, 4072, 4211, 4294], 'pathogenesis': [566], 'Th1-mediated': [568], 'chronic': [569], 'inflammatory': [570, 584, 626, 831], 'disorders': [571], 'mice': [573, 834, 1238], 'humans,': [575], 'such': [576], 'as': [577, 1547, 1886, 1959, 1986, 2032, 2066, 2266, 2719, 2791], 'diabetes': [578], 'mellitus,': [579], 'multiple': [580], 'sclerosis,': [581], 'arthritis,': [582], 'bowel': [585], 'disease': [586, 832], '(2Adorini': [587], 'L.': [588, 4345], 'Cell.': [589, 976, 1088, 1227, 1648, 1712, 1744, 2000, 2080, 2219, 2281, 2733, 3349, 3732, 3766], 'Mol.': [590, 975, 1087, 1226, 1647, 1711, 1743, 1999, 2079, 2218, 2280, 2732, 3348, 3731, 3765], 'Life': [591], 'Sci.': [592, 683, 734, 1021, 3637], '1999;': [593, 1690, 1746, 4335], '55:': [594], '1610-1625Crossref': [595], '(78)': [598], 'Therefore,': [601, 925, 3742, 4482], 'understanding': [602], 'events': [605], 'lead': [607], 'may': [612, 799, 1139, 1353, 1545, 4312], 'provide': [613], 'insight': [615], 'into': [616, 3142, 3162, 3807], 'how': [617], 'Th1': [619, 760, 814], 'regulated': [622], 'infectious': [624, 829], 'diseases.': [627], 'Biologically': [628], 'active': [629], 'heterodimer': [633], 'composed': [634], 'two': [636, 645, 4503], 'subunits,': [637], 'p35,': [640], 'encoded': [643], 'separate': [646], 'genes.': [647], 'constitutively': [652], 'many': [655, 1182], 'cell': [656, 1796, 2061, 3155], 'types': [657], '(3Gubler': [658, 709], 'U.': [659, 684, 710, 735, 3638], 'Chua': [660, 711], 'A.O.': [661, 712], 'Schoenhaut': [662, 713], 'D.S.': [663, 714], 'Dwyer': [664, 715], 'C.M.': [665, 716], 'McComas': [666, 717], 'W.': [667, 718], 'Motyka': [668, 719], 'R.': [669, 720, 841, 882, 3486, 3789, 4349], 'Nabavi': [670, 721], 'N.': [671, 722, 853, 1018, 3671], 'Wolitzky': [672, 723], 'A.G.': [673, 724], 'Quinn': [674, 725], 'P.M.': [675, 726], 'Familletti': [676, 727], 'P.C.': [677, 728], 'Gately': [678, 729], 'M.K.': [679, 730], 'Proc.': [680, 731, 3634], 'Natl.': [681, 732, 3635], 'Acad.': [682, 733, 1020, 3636], 'S.': [685, 736, 871, 1082, 1221, 1642, 1994, 2074, 2213, 2275, 2727, 3343, 3639, 3726, 3760, 4369], 'A.': [686, 737, 763, 906, 1280, 1282, 1325, 1389, 1710, 2395, 3523, 3599, 3640, 3669, 4271, 4343], '1991;': [687, 738], '88:': [688, 739], '4143-4147Crossref': [689, 740], '(565)': [692, 743], 'contrast,': [696, 4430], 'only': [701], 'produce': [706], 'Scholar)': [745, 2411, 3802], 'strongly': [748, 4192, 4217, 4473], 'vivo': [758, 802, 1302], 'stimulate': [759], "(4D'Andrea": [762], 'Rengaraju': [764], 'M.': [765, 771, 773, 777, 865, 1385, 1740, 4341], 'Valiante': [766], 'N.M.': [767], 'Chehimi': [768], 'J.': [769, 782, 855, 869, 908, 910, 912, 915, 972, 1114, 1156, 1268, 1285, 1332, 1392, 1599, 1688, 1897, 2043, 2237, 2299, 2402, 2802, 3367, 3606, 3657, 3792, 4333, 4352, 4376], 'Kubin': [770], 'Aste': [772], 'Chan': [774], 'S.H.': [775], 'Kobayashi': [776], 'Young': [778], 'D.': [779, 867, 879], 'Nickbarg': [780], 'E.': [781, 861, 1698, 3480, 3631], 'Exp.': [783, 1286, 3793], 'Med.': [784, 1287, 3794], '1992;': [785], '176:': [786], '1387-1398Crossref': [787], '(1157)': [790], 'Furthermore,': [793, 1130], 'subunit': [797, 806], 'heterodimerize': [800], 'IL-23': [812], 'influences': [813], 'secretion': [818], 'has': [820, 1174, 2384, 3504, 3547], 'role': [827], 'independent': [835], '(5Oppmann': [838], 'B.': [839, 843, 849, 4351], 'Lesley': [840], 'Blom': [842], 'Timans': [844], 'J.C.': [845], 'Xu': [846], 'Y.': [847, 873, 1019], 'Hunte': [848], 'Vega': [850], 'F.': [851, 859, 3785], 'Yu': [852], 'Wang': [854], 'Singh': [856], 'K.': [857, 1109, 1151, 1284, 1331, 1594, 1892, 2038, 2232, 2294, 2401, 2797, 3362, 3605, 3633, 3652, 3667], 'Zonin': [858], 'Vaisberg': [860], 'Churakova': [862], 'T.': [863, 1276, 3665], 'Liu': [864, 872], 'Gorman': [866], 'Wagner': [868], 'Zurawski': [870], 'Abrams': [874], 'J.S.': [875], 'Moore': [876], 'K.W.': [877], 'Rennick': [878], 'de': [880], 'Waal-Malefyt': [881], 'Hannum': [883], 'C.': [884, 1107, 1149, 1278, 1323, 1592, 1696, 1890, 2036, 2230, 2292, 2393, 2795, 3360, 3525, 3597, 4273], 'Bazan': [885], 'J.F.': [886], 'Kastelein': [887], 'R.A.': [888], 'Immunity.': [889], '2000;': [890, 1334, 2404, 3608, 4355], '715-725Abstract': [892], 'Full': [893, 895, 1120, 1122, 1162, 1164, 1605, 1607, 1903, 1905, 2049, 2051, 2243, 2245, 2305, 2307, 2808, 2810, 3373, 3375, 4358, 4360], 'Text': [894, 896, 1121, 1123, 1163, 1165, 1606, 1608, 1904, 1906, 2050, 2052, 2244, 2246, 2306, 2308, 2809, 2811, 3374, 3376, 4359, 4361], 'PDF': [897, 1124, 1166, 1609, 1907, 2053, 2247, 2309, 2812, 3377, 4362], '(2300)': [900], 'Scholar,': [902, 1274, 1694, 2228, 2290, 3358, 3615, 3648, 3663, 3775, 4339, 4367], '6Cooper': [903], 'A.M.': [904], 'Kipnis': [905], 'Turner': [907], 'Magram': [909, 971], 'Ferrante': [911], 'Orme': [913], 'I.M.': [914, 1321, 2391, 3558, 3595], '2002;': [917], '168:': [918], '1322-1327Crossref': [919], '(267)': [922], 'studies': [926, 1132, 2389, 3320], 'transcriptional': [929, 1207], 'regulation': [930], 'focused': [932], 'An': [937, 1722], 'NF-κB': [938, 1856, 2191, 2200, 4015], 'from': [940, 993, 1102, 1345, 1406, 1565, 1734, 1825, 1833, 1870, 2260, 2323, 2378, 2470, 2523, 3395, 3411, 3435, 3500, 3543, 3914, 3953, 4053, 4080], '–131': [941], '–121': [943], 'relative': [944, 3901], 'transcription': [947, 1061, 1576, 2136, 3905, 4260, 4505], 'start': [948, 1577, 2137, 3906], 'necessary': [957], 'activity': [962, 3442, 3461, 3962], '(7Murphy': [965], 'T.L.': [966], 'Cleveland': [967], 'M.G.': [968], 'Kulesza': [969], 'P.': [970, 3482], 'Murphy': [973], 'K.M.': [974], 'Biol.': [977, 1089, 1115, 1157, 1228, 1600, 1649, 1713, 1745, 1898, 2001, 2044, 2081, 2220, 2238, 2282, 2300, 2734, 2803, 3350, 3368, 3733, 3767, 4353], '15:': [979, 3532, 4280], '5258-5267Crossref': [980], 'promoter,': [988, 1181], 'consensus': [990, 2148, 2154, 2199, 3509, 3980, 4014, 4468], 'Ets': [991, 1318, 4308], 'sequence': [992, 2140, 2163, 3499, 4079], '–211': [994], '–207': [996], 'binds': [998, 1448], 'multiprotein': [1000], 'complex': [1001, 1446, 3478, 3998, 4027, 4066, 4101, 4122, 4143, 4196, 4221, 4231, 4246, 4298, 4396, 4427, 4478], 'was': [1002, 1304, 1308, 1732, 2327, 2481, 2583, 2651, 2701, 2711, 2758, 2774, 2823, 2849, 2989, 3110, 3157, 3167, 3173, 3187, 3280, 3292, 3399, 3690, 3819, 3827, 3908, 3921, 3944, 3966, 4108, 4123, 4135, 4464], 'implicated': [1003], 'IFN-γ': [1010, 1189, 1206, 1537, 1829, 1944, 2471, 2684, 2755, 2779, 3593, 3699, 3716, 3754, 3834, 3870, 3936], '(8Ma': [1011], 'X.': [1012, 1327, 1387, 2397, 3601, 3777], 'Gri': [1013, 3780], 'Trinchieri': [1015, 1328, 1390, 2398, 3602, 3790], 'Ann.': [1017], '1996;': [1022, 1714, 3490, 3795], '795:': [1023], '357-360Crossref': [1024], '(15)': [1027], 'We': [1030, 3702], 'had': [1031, 3456], 'initially': [1032], 'reported': [1033], 'comprehensive': [1035], 'functional': [1036, 1131, 1343, 3323, 3694, 3961], 'analysis': [1037, 1344], 'promoters': [1045, 2422], 'RAW': [1047, 1787, 2552, 3431, 3718, 3808], '264.7': [1048, 1788, 1876, 2060, 2553, 2745, 3432, 3719, 3809], 'control': [1051, 1404, 3324], 'were': [1053, 1624, 1677, 1772, 1798, 1823, 1832, 1868, 1878, 1918, 1935, 1971, 1984, 2011, 2064, 2099, 2264, 2366, 2423, 2439, 2476, 2502, 2512, 2521, 2535, 2558, 2590, 2640, 2658, 2669, 2677, 2747, 2785, 2860, 2896, 2918, 2929, 2960, 2973, 3012, 3019, 3055, 3074, 3096, 3119, 3207, 3247, 3257, 3273, 3422, 3803, 3884, 3892, 4170, 4210, 4291], 'heat-killed': [1056], 'Listeria': [1057], 'monocytogenes-': [1058], 'LPS-activated': [1060, 2473, 3430], 'gene.': [1065], 'These': [1066, 1475, 4037, 4139], 'include': [1068], 'C/EBP': [1070, 2188], '–96': [1074], '–88': [1076], '(9Plevy': [1077, 1216, 1637, 1989, 2069, 2208, 2270, 2722, 3338, 3721, 3755], 'S.E.': [1078, 1113, 1155, 1217, 1598, 1638, 1896, 1990, 2042, 2070, 2209, 2236, 2271, 2298, 2723, 2801, 3339, 3366, 3722, 3756], 'Gemberling': [1079, 1110, 1152, 1218, 1595, 1639, 1893, 1991, 2039, 2071, 2210, 2233, 2272, 2295, 2724, 2798, 3340, 3363, 3723, 3757], 'J.H.': [1080, 1111, 1153, 1219, 1596, 1640, 1894, 1992, 2040, 2072, 2211, 2234, 2273, 2296, 2725, 2799, 3341, 3364, 3724, 3758], 'Hsu': [1081, 1220, 1641, 1993, 2073, 2212, 2274, 2726, 3342, 3725, 3759], 'Dorner': [1083, 1222, 1643, 1995, 2075, 2214, 2276, 2728, 3344, 3727, 3761], 'A.J.': [1084, 1223, 1644, 1996, 2076, 2215, 2277, 2729, 3345, 3728, 3762], 'Smale': [1085, 1224, 1645, 1997, 2077, 2216, 2278, 2730, 3346, 3729, 3763], 'S.T.': [1086, 1225, 1646, 1998, 2078, 2217, 2279, 2731, 3347, 3730, 3764], '1997;': [1090, 1229, 1270, 1288, 1650, 2002, 2082, 2221, 2283, 2735, 3351, 3531, 3734, 3768, 4279], '17:': [1091, 1230, 1651, 2003, 2083, 2222, 2284, 2736, 3352, 3735, 3769], '4572-4588Crossref': [1092, 1231, 1652, 2004, 2084, 2223, 2285, 2737, 3353, 3736, 3770], '(273)': [1095, 1234, 1655, 2007, 2087, 2226, 2288, 2740, 3356, 3739, 3773], 'Scholar),': [1097, 3538, 3569, 3682, 4286], 'AP-1': [1100, 2194, 2358], '–81': [1103], '–75': [1105], '(10Zhu': [1106, 1148, 1591, 1889, 2035, 2794], 'Gagnidze': [1108, 1150, 1593, 1891, 2037, 2231, 2293, 2796, 3361], 'Plevy': [1112, 1154, 1597, 1895, 2041, 2235, 2297, 2800, 3365], 'Chem.': [1116, 1158, 1601, 1899, 2045, 2239, 2301, 2804, 3369, 4354], '2001;': [1117, 1159, 1602, 1900, 2046, 2240, 2302, 2805, 3370, 3675, 4378], '276:': [1118, 1160, 1603, 1901, 2047, 2241, 2303, 2806, 3371], '18519-18528Abstract': [1119, 1161, 1604, 1902, 2048, 2242, 2304, 2807, 3372], '(82)': [1127, 1169, 1612, 1910, 2056, 2250, 2312, 2815, 3380], 'suggested': [1133, 1305, 3471, 4073], 'several': [1135], 'other': [1136, 1350, 2255], 'regulate': [1140], 'Although': [1172], 'much': [1173], 'learned': [1176], 'about': [1177], 'biologic': [1184], 'questions': [1185], 'remain.': [1186], 'For': [1187, 2090], 'example,': [1188], 'optimal': [1193], 'production': [1194, 1255], 'Mechanisms': [1203], 'governing': [1204], 'remain': [1214, 1382], 'controversial': [1215], 'deficient': [1239], 'factors': [1244, 4261], 'IRF-1,': [1245], 'IRF-2,': [1246], 'selective': [1251], 'defect': [1252], '(11McElligott': [1256], 'D.L.': [1257, 1685, 3619], 'Phillips': [1258], 'J.A.': [1259, 1700], 'Stillman': [1260], 'C.A.': [1261], 'Koch': [1262], 'R.J.': [1263, 1742], 'Mosier': [1264], 'D.E.': [1265], 'Hobbs': [1266], 'M.V.': [1267], '159:': [1271], '4180-4186PubMed': [1272], '12Scharton-Kersten': [1275], 'Contursi': [1277, 1322, 2392, 3596], 'Masumi': [1279, 1324, 2394, 3598], 'Sher': [1281], 'Ozato': [1283, 1330, 2400, 3604, 3632, 3651], '186:': [1289], '1523-1534Crossref': [1290], '(186)': [1293], 'mechanism': [1298], 'phenomenon': [1303], 'when': [1306, 3829, 3894, 3946, 4126], 'described': [1309, 1590, 1620, 1678, 1888, 1988, 2034, 2068, 2206, 2386, 2721, 2793], 'element': [1319, 2157, 2195, 2203, 3325, 3845, 4091], '(13Wang': [1320, 2390, 3594], 'Ma': [1326, 1386, 2396, 3600], '165:': [1335, 2405, 3609], '271-279Crossref': [1336, 2406, 3610], '(160)': [1339, 1751, 2409, 3613], 'study': [1347], 'downstream': [1351, 1549, 3449], 'mediate': [1355], 'effect': [1357, 4441], 'ICSBP.': [1359], 'Similarly,': [1360], 'anti-inflammatory': [1365], 'potently': [1368], 'inhibits': [1369], 'transcription.': [1372, 1509], 'effects': [1374], 'unknown': [1383], '(14Aste-Amezaga': [1384], 'Sartori': [1388], '1998;': [1394], '160:': [1395], '5936-5944PubMed': [1396], 'region': [1405, 1423, 3331, 3475, 3542, 3684, 3858, 3952, 4514], '–71': [1407, 3436], 'characterized.': [1417], 'Site-directed': [1418], 'mutagenesis': [1419], 'suggests': [1420], 'Electrophoretic': [1433], 'assays': [1436, 1980, 1983], '(EMSA)': [1437], 'affinity': [1440, 2526], 'experiments': [1442, 3054, 4169, 4457], 'demonstrate': [1443], 'multi-protein': [1445], 'region,': [1451, 3882, 4167], '(–61': [1455], '–54)': [1457], '(–71': [1460], '–62)': [1462], 'major': [1464, 4504], 'components.': [1465], 'dependent': [1471], 'upon': [1472, 3696], 'binding.': [1474], 'vitro': [1477], 'interactions': [1478, 1493, 3879], 'immunoprecipitation': [1487, 3060, 3190], 'experiments.': [1488], 'protein-protein': [1492], 'co-immunoprecipitation.': [1498], 'Expression': [1510], 'RAW264.7': [1517, 1531, 1946, 2474, 2615, 3072, 3915], 'accumulation.': [1527], 'treatment': [1529], 'prior': [1533], 'abrogates': [1539], 'NFAT-ICSBP': [1541, 1544], 'Thus,': [1543], 'act': [1546], 'target': [1550], 'inhibition': [1553], 'Plasmid': [1559], 'Constructs—The': [1560], '–101': [1566, 2324, 3412, 3816], '+55,': [1568, 3414, 3818], 'or': [1569, 1948, 1981, 2832, 2945, 3092, 3196, 3926, 4016, 4194, 4418], '–355': [1570], '+55': [1572], '(relative': [1573], 'site),': [1578], 'acetyltransferase': [1580], '(CAT)': [1581], 'reporter,': [1582], 'luciferase': [1584, 1982, 3748, 3814], 'reporter': [1585, 1975, 3710, 3749, 3964], 'plasmids': [1586, 1619, 1660, 2589, 2937, 3711, 3750], 'previously': [1589, 1679, 1887, 1987, 2033, 2067, 2207, 2720, 2792, 3704], 'All': [1615], 'two-base': [1616], 'pair': [1617, 3164, 3392], 'mutant': [1618, 1635, 2256, 2346, 2353, 2360, 4128], 'paper': [1623], 'generated': [1625, 3400], 'two-step': [1627], 'PCR': [1628, 2330, 2368, 3295], 'using': [1629, 1881, 1920, 1973, 2331, 2528, 2660, 2703, 3057, 4466], 'overlapping': [1630], 'internal': [1631], 'primers': [1632, 3297], 'containing': [1633, 2983, 3124, 3180, 3949, 3978, 4012], 'Mammalian': [1658], 'wild': [1663], 'type': [1664], 'NFATc1': [1665, 1838, 1840, 2833, 2915, 4415, 4435], '(from': [1666, 1674, 2347], 'Tammy': [1667], 'Nachman': [1668], 'Melissa': [1670], 'Brown)': [1671], 'NFATc2': [1673, 1842, 4417], 'Anjana': [1675], 'Rao)': [1676], '(15Sherman': [1680], 'M.A.': [1681, 1687], 'Powell': [1682], 'D.R.': [1683], 'Weiss': [1684], 'Brown': [1686], '162:': [1691], '2820-2828PubMed': [1692], '16Luo': [1695], 'Burgeon': [1697], 'Carew': [1699], 'McCaffrey': [1701], 'P.G.': [1702, 1708, 3527, 4275], 'Badalian': [1703], 'T.M.': [1704], 'Lane': [1705], 'W.S.': [1706], 'Hogan': [1707, 3526, 4274], 'Rao': [1709], '16:': [1715], '3955-3966Crossref': [1716], '(173)': [1719], 'plasmid': [1724, 1771, 2015, 2581], 'protein,': [1730], '(Dn-NFAT),': [1731], 'obtained': [1733], 'Roger': [1735], 'Davis': [1736, 1741], '(17Chow': [1737], 'C.W.': [1738], 'Rincon': [1739], '19:': [1747, 3676], '2300-2307Crossref': [1748], 'plasmid,': [1758, 3815], 'GST': [1760, 2903], 'mammalian': [1761, 2912, 2922], 'vector': [1763, 2924], 'pEBG,': [1764], 'CD4': [1768, 2571, 2662], '(hCD4)': [1769], 'provided': [1773, 1927, 3068], 'Curt': [1775], 'Horvath,': [1776], 'Patricia': [1777], 'Cortes,': [1778], 'Adrian': [1780], 'Ting,': [1781], 'respectively.': [1782], 'Cell': [1783], 'Lines': [1784], 'Reagents—The': [1786], 'macrophage': [1790], 'line': [1791, 1797], '293T': [1795, 1916, 1957, 2927], 'maintained': [1799], 'DMEM': [1801, 2596, 2624, 2650, 3078], 'supplemented': [1802], '10%': [1804, 2626, 2883, 3032], 'fetal': [1805, 2627], 'bovine': [1806, 2443, 2628], 'serum': [1807, 2444], '(Sigma)': [1808], '1%': [1810, 2631, 3099, 3216], 'penicillin-streptomycin.': [1811], 'Salmonella': [1812], 'enteriditis': [1813], '13-acetate': [1817], '(PMA),': [1818], 'ionomycin,': [1819], 'purchased': [1824, 1869], 'Sigma.': [1826], 'Murine': [1827, 2545], 'recombinant': [1828], 'R&D': [1834], 'Inc.': [1835, 1874], 'Antibodies': [1836, 4172, 4204, 4238], '(7A6),': [1839], '(K-18),': [1841], '(M-20),': [1843, 1849], 'NFATc3': [1844], '(M-75),': [1845], 'NFATc4': [1846], '(C-20),': [1847, 1860], 'IRF-1': [1848, 4240, 4451], 'IRF-2': [1850, 4242, 4453], '(C-19),': [1851, 1855], 'IRF-4': [1852, 4227, 4485], '(M-17),': [1853], 'p50': [1857, 4289], '(NLS),': [1858], 'p65': [1859], 'c-Rel': [1861], '(C),': [1862], 'PU.1': [1863, 4311, 4387, 4433], '(T-21),': [1864], 'STAT1': [1866], '(E-23)': [1867], 'Santa': [1871], 'Cruz': [1872], 'Biotechnology,': [1873, 3064], 'Transfections—RAW': [1875], 'transiently': [1879, 2559], 'transfected': [1880, 1933, 2560, 2930, 3806], 'SuperFect': [1882], 'Transfection': [1883], 'Reagent': [1884], '(Qiagen)': [1885, 2604], 'Transient': [1913], 'transfections': [1914], 'performed': [1919, 1985, 2265, 2712, 3056, 4465], 'LipofectAMINE': [1921], 'Plus™': [1922], 'reagent': [1923], '(Invitrogen)': [1924], 'per': [1925], 'protocol.': [1928], 'After': [1929, 2653], '36': [1930, 2654, 2939], 'h,': [1931, 2655], 'activated': [1936, 2689, 2946, 3088, 3515, 3820], '5': [1938, 2691, 3269, 4095], 'μg/ml': [1939, 2692, 2838, 3004, 3133], '10': [1942, 2681, 2968, 2980, 3116, 3150], 'ng/ml': [1943, 1950, 2682], '(for': [1945, 1956, 3511], 'cells),': [1947], '50': [1949, 2646, 2837, 3003], 'PMA': [1951, 2948], '1': [1953, 2454, 2531, 2686, 2761, 2776, 2885, 3132], 'μm': [1954], 'ionomycin': [1955, 2952], 'cells)': [1958, 3517], 'indicated': [1960], 'under': [1961, 2019], '"Results."': [1962], 'Ten': [1963], '12': [1965, 2674], 'h': [1966, 2687, 2762, 2777, 2855, 2940], 'after': [1967], 'activation,': [1968], 'harvested': [1972, 2702, 2786, 2961], '1×': [1974, 2891], 'lysis': [1976, 3147], 'buffer': [1977, 2433, 2448, 2865, 2966, 3148], '(Promega).': [1978], 'CAT': [1979, 3418], 'Cells': [2010, 2676, 2959, 3118], 'co-transfected': [2012], 'expresses': [2017], 'β-galactosidase': [2018], 'CMV': [2021], 'correct': [2024], 'differences': [2026], 'transfection': [2028, 3426], 'efficiency': [2029], 'experiments,': [2031, 2770], 'EMSA—RAW': [2059], 'extracts': [2063, 2469, 4151], 'prepared': [2065, 3913], '200': [2092, 2426, 3143], 'ng': [2093], 'double-stranded': [2095], 'oligonucleotide': [2096], 'probes': [2098, 2121, 2183, 2257], 'labeled': [2100], '[α-32P]dGTP': [2102], '[α-32P]dCTP': [2104], 'Klenow,': [2106], 'purified': [2108, 3281], 'Quick': [2110], 'Spin': [2111], 'columns': [2112], '(Sephadex': [2113], 'G-50)': [2114], '(Roche).': [2115], 'Our': [2116], 'numerical': [2117], 'nomenclature': [2118], 'EMSA': [2120, 2143, 2169, 4463], 'denotes': [2122], 'sequences': [2124, 2365, 2375], 'spanned': [2125], 'within': [2126], 'respect': [2133], 'site.': [2138], 'probe': [2144, 2150, 2159, 2170, 2179, 3896, 3947, 3987, 4113, 4129], '77/46': [2145, 3897, 3988], '5′-gatcTCAGTTTCTACTTTGGGTTTCCATCAGAAAGT,': [2147], '5′-gatcGCCCAAAGAGGAAAATTTATTTCATA,': [2152], 'IFN-stimulated': [2155], '(ISRE)': [2158], '5′-gatcACTTTCAGTTTCAT.': [2161], 'IL-18': [2166], 'p1': [2167], '5′-gatcTCAGTTGAAGTCTGGAAAGAGAAACTTAGTGAGA,': [2172], 'inducible': [2176, 3407], 'nitric-oxide': [2177], 'synthetase': [2178], '5′-gatcACTGACACTGTCAATATTTCACTTTCATAATGGAAAAT.': [2181], 'Other': [2182], 'spanning': [2184, 3298], '(112/78),': [2190], '(146/107),': [2193], '(88/63),': [2196], '10Zhu': [2229, 2291, 3359], 'Sequences': [2253], 'available': [2259, 2377], 'authors.': [2262], 'EMSAs': [2263, 3883, 4001], 'previous': [2268, 2388, 3319], 'publications': [2269], 'Affinity': [2316], 'Binding': [2317, 3312, 4521], 'Assay—A': [2318], 'biotinylated': [2319], '–36': [2326], 'amplified': [2328, 2369], '5′-biotin-labeled': [2333], 'upstream': [2334, 3453], 'primer,': [2335], 'conjugated': [2337, 2424], 'Dynabeads': [2339], '(M-280': [2340], 'streptavidin,': [2341], 'Dynal®).': [2342], '–62': [2348, 3328, 3546, 3954, 4054], '–57),': [2350], '(–68': [2354], '–63),': [2356], '(–80': [2361], '–75)': [2363], 'same': [2372, 4440], 'method': [2373], '(mutant': [2374], 'authors).': [2380], 'experimental': [2382], 'procedure': [2383], 'Technical': [2414], 'Handbook': [2415], 'Dynal®': [2417], 'some': [2419, 2769], 'modifications.': [2420, 3071], '5′-Biotin-labeled': [2421], 'μg': [2427, 2466, 2563, 2568, 2819, 2827, 2985, 3184, 3193], 'streptavidin': [2429], 'beads': [2430, 2438, 2996, 3202, 3206], 'TE': [2432, 3242], '(pH': [2434], '7.9).': [2435], 'DNA-conjugated': [2437], 'blocked': [2440], '0.5%': [2442, 2874, 3219], 'albumin': [2445], 'TGED': [2447, 2480, 2516, 2529], '(10': [2449, 2756, 2772], 'mm': [2450, 2455, 2867, 2872, 2878, 2881, 2886, 3025, 3030, 3035, 3039, 3042, 3128], 'Tris,': [2451, 2868, 3026], 'pH': [2452, 2869, 3027], '8.0,': [2453, 2870], 'EDTA,': [2456, 2879], '0.1': [2458, 3222], 'm': [2459, 2532, 3270], 'NaCl)': [2460], 'overnight': [2461], '4': [2463, 2506, 2636, 2697, 2842, 2857, 2957, 3008, 3192, 4117, 4252], '°C.': [2464, 2858], '500': [2465, 2489, 2818], 'then': [2477, 2611, 2641, 2678, 2759, 2850, 2974, 3045, 3136], 'added,': [2478], 'adjust': [2484], 'final': [2486, 2493], 'volume': [2487], 'μl': [2490, 2601, 2993, 3144, 3251, 3267], 'concentration': [2494, 3114], 'NaCl': [2496], '100': [2498], 'mm.': [2499], 'mixtures': [2501], 'subsequently': [2503], 'incubated': [2504, 2824, 2990, 3909], '°C': [2507, 2843, 3009, 3261], '2–4': [2509], 'h.': [2510, 2637, 2675, 2698, 2958], 'Beads': [2511, 2859, 3011], 'extensively': [2513, 2861, 3013], 'washed': [2514, 2642, 2862, 3014, 3120, 3208], 'buffer,': [2517], 'DNA-binding': [2519], 'proteins': [2520, 2910, 3912, 4161], 'eluted': [2522, 3020, 3248], 'column': [2527], 'NaCl.': [2533, 3271], 'Proteins': [2534, 2895, 3018, 3272], 'separated': [2536, 2897], 'SDS-PAGE': [2538, 2892, 2899, 3048], 'immunoblot': [2540, 2901], 'detection': [2541], 'specific': [2543, 3877, 4160], 'antibodies.': [2544], 'Expression—1.5': [2549], '×': [2550, 3084], '107': [2551], '150-mm': [2556, 2753], 'plates': [2557], '15': [2562, 2567, 2577], 'Dn-NFAT': [2565], 'plasmids.': [2573], 'control,': [2576], 'μgofthe': [2578], 'empty': [2579], 'pCDNA3': [2582], 'instead': [2585], 'Dn-NFAT.': [2587], 'suspended': [2591, 2963], '2': [2593, 2826, 2880, 2984, 3034, 3038, 4304], 'ml': [2594, 2621, 2647], 'mixed': [2598], '120': [2600], 'Superfect®': [2603], 'room': [2606, 3107], 'temperature': [2607], '5–10': [2609], 'min,': [2610], 'added': [2612, 2760, 2775, 2851], 'PBS-washed': [2614], 'additional': [2619, 2673, 2696], '13': [2620], 'complete': [2623, 2649, 3077], '(containing': [2625], 'serum,': [2629], 'penicillin': [2632], 'streptomycin)': [2634], 'added.': [2652], 'CD4-positive': [2656, 2667], 'selected': [2659], 'Positive': [2663], 'Isolation': [2664], 'Kit': [2665], '(Dynal®).': [2666], 'cultured': [2670, 2748, 3075], 'pretreated': [2679], 'Total': [2699], 'RNA': [2700], 'RNeasy®': [2704], 'Mini': [2705], 'Kits': [2706], '(Qiagen).': [2707], 'reverse': [2709], 'transcriptase-PCR': [2710], 'detect': [2714], 'Co-immunoprecipitation': [2743], 'Experiments—RAW': [2744], '90%': [2750], 'confluence': [2751], 'plates.': [2754], 'ng/ml)': [2757, 2773, 2950], 'before': [2763, 2778], '(5': [2765], 'μg/ml)': [2766], 'activation.': [2767, 2780], 'Four': [2781], 'hours': [2782], 'later,': [2783], 'extract': [2789, 2822], 'preparation,': [2790], 'antibody': [2829, 4180, 4216, 4225], 'presence': [2835, 3001, 3264], 'ethidium': [2839, 3005], 'bromide': [2840, 3006], 'overnight.': [2844, 3010], 'Protein': [2845, 3942], 'G-Sepharose®': [2846], '(Amersham': [2847, 2997, 3203], 'Biosciences)': [2848, 2998], 'another': [2853, 2956, 4462], '3': [2854], 'WCE': [2864, 2965, 3016], '(50': [2866, 2949], '280': [2871], 'NaCl,': [2873, 3031], 'Nonidet': [2875, 3217], 'P-40,': [2876, 3218], '0.2': [2877], 'EGTA,': [2882], 'glycerol,': [2884, 3033], 'dithiothreitol),': [2887], 'boiled': [2889], 'loading': [2893], 'buffer.': [2894, 3017], 'detection.': [2902], 'Pull-down': [2904], 'Experiments—For': [2905], 'precipitation': [2906], 'GST-NFAT': [2908], 'fusion': [2909, 2933], 'deleted': [2914], 'cDNA': [2916], 'constructs': [2917], 'subcloned': [2919], 'pEBG': [2925], 'in-frame.': [2926], 'GST-NFATc1': [2932], 'either': [2942, 3857], 'left': [2943], 'unactivated': [2944, 3428], '(1': [2953, 3127], 'μm)': [2954], 'min': [2969, 3105, 3151], 'ice.': [2971, 3153], 'Lysates': [2972], 'centrifuged': [2975], '14,000': [2977], 'rpm': [2978], 'min.': [2981], 'Supernatant': [2982], 'total': [2987], 'protein': [2988, 3200, 4148], '30': [2992, 3104], 'glutathione-Sepharose®': [2995], 'Elution': [3022, 3253], 'Buffer': [3023, 3179, 3213], '(25': [3024], '8.3,': [3028], '300': [3029], 'reduced': [3036, 3439], 'glutathione,': [3037], 'dithiothreitol,': [3040], '0.5': [3041], 'phenylmethylsulfonyl': [3043, 3129], 'fluoride),': [3044], 'analyzed': [3046, 3423], 'immunoblot.': [3050], 'Chromatin': [3051, 3176], 'Immunoprecipitation': [3052, 3177], 'Assays—These': [3053], 'assay': [3061], 'kit': [3062], '(Upstate': [3063], 'Inc.),': [3065], 'following': [3066, 3424], 'protocol': [3069], 'medium': [3079], '80%': [3081, 3445], 'confluence.': [3082], '2–5': [3083], '106': [3085], '(unactivated,': [3087], 'IFN-γ/LPS,': [3091], '(CsA)/IFN-γ/LPS)': [3095], 'fixed': [3097], 'formaldehyde': [3100], '(final': [3101], 'concentration)': [3102], 'temperature.': [3108], 'CsA': [3109], 'μg/ml.': [3117], 'cold': [3122], 'PBS': [3123], 'protease': [3125, 3181], 'inhibitors': [3126], 'fluoride': [3130], 'pepstatin': [3134], 'A),': [3135], 'collected': [3137], 'centrifugation': [3139], 'resuspended': [3141], 'SDS': [3146], 'lysate': [3156], 'sonicated': [3158], 'dissociate': [3160], '200–1000-base': [3163], 'fragments.': [3165], 'Debris': [3166], 'removed': [3168], 'centrifugation.': [3170], 'supernatant': [3172], 'diluted': [3174], 'Dilution': [3178], 'inhibitors.': [3182], 'One': [3183], 'anti-ICSBP': [3195, 4215], 'anti-NFATc1': [3197], 'antibodies,': [3198], 'G-agarose': [3201], 'Biosciences).': [3204], 'Radioimmune': [3210], 'Precipitation': [3211], 'Assay': [3212], '(1×': [3214], 'sodium': [3220], 'deoxycholate,': [3221], 'SDS),': [3223], 'Low': [3224], 'Salt': [3225, 3231], 'Immune': [3226, 3232, 3237], 'Complex': [3227, 3233, 3238, 3919, 4106], 'Wash': [3228, 3234, 3239], 'Buffer,': [3229, 3235, 3240], 'High': [3230], 'LiCl': [3236], 'sequence.': [3244], 'DNA-protein': [3245, 3255, 3878, 3887, 4230], 'complexes': [3246], '250': [3250], 'Buffer.': [3254], 'cross-links': [3256], 'reversed': [3258], '65': [3260], '20': [3266], 'digested': [3274], 'proteinase': [3276], 'K,': [3277], 'phenol/chloroform': [3283], 'extraction': [3284], 'recovered': [3286], 'ethanol': [3288], 'precipitation.': [3289], 'Immunoprecipitated': [3290], 'utilized': [3293], '–146': [3299], '+40': [3301], 'Characterization': [3308], 'Site': [3313], 'Promoter—Our': [3318], 'around': [3326], '–57': [3330, 3956], 'To': [3383, 3875, 4158, 4446], 'better': [3384], 'characterize': [3385, 3876], 'element,': [3387], 'series': [3389], '2-base': [3391], 'substitution': [3393], 'mutants': [3394, 3855], '–73': [3396], 'context': [3403], 'minimal': [3406, 3457], 'linked': [3415], 'reporter.': [3419], 'Promoter': [3420], 'activities': [3421], 'transient': [3425], 'Mutants': [3434, 3448, 3839], '–60': [3438], 'LPS-induced': [3440, 3851], 'up': [3443], '(Fig.': [3446, 3462, 3837, 3873, 3917, 3938, 3968, 4002, 4029, 4092, 4114, 4131, 4198, 4232, 4249, 4301, 4406, 4442], '1A).': [3447, 3463], '–59': [3451], '–72': [3455], 'affects': [3458], 'bioinformatic': [3465], 'search': [3466], 'potential': [3468], 'cis-regulatory': [3469], 'small': [3474], 'relatively': [3477], '(18Wingender': [3479], 'Dietze': [3481], 'Karas': [3483], 'H.': [3484], 'Knuppel': [3485], 'Nucleic': [3487], 'Acids': [3488], 'Res.': [3489], '24:': [3491], '238-241Crossref': [3492], '(848)': [3495], '–63': [3501], 'strong': [3505, 3824], 'homology': [3506, 3549], 'factor': [3513, 3578, 4506], 'T': [3516], '((T/A)GGAAAN)': [3521], '(19Rao': [3522, 4270], 'Luo': [3524, 4272], '707-747Crossref': [3533, 4281], '(2227)': [3536, 4284], '–74': [3544, 4081], 'weaker': [3548], 'ISRE': [3552, 3848, 4018, 4090, 4469], '((A/G)NGAAANNGAAACT)': [3553], '(20Darnell': [3554], 'Jr.,': [3555], 'J.E.': [3556, 3654], 'Kerr': [3557], 'Stark': [3559], 'G.R.': [3560], 'Science.': [3561], '1994;': [3562, 3659], '264:': [3563], '1415-1421Crossref': [3564], '(5062)': [3567], '(IRF)': [3579], 'family': [3580, 3587, 4183, 4208, 4258, 4309, 4490], 'members.': [3581], 'members': [3583, 4184, 4209, 4491], 'IRF': [3586, 4207, 4489], '21Driggers': [3616], 'P.H.': [3617], 'Ennist': [3618], 'Gleason': [3620], 'S.L.': [3621], 'Mak': [3622], 'W.H.': [3623], 'Marks': [3624], 'M.S.': [3625], 'Levi': [3626], 'B.Z.': [3627], 'Flanagan': [3628], 'J.R.': [3629], 'Appella': [3630], '1990;': [3641], '87:': [3642], '3743-3747Crossref': [3643], '(314)': [3646], '22Politis': [3649], 'A.D.': [3650], 'Coligan': [3653], 'Vogel': [3655], 'S.N.': [3656], '152:': [3660], '2270-2278PubMed': [3661], '23Taniguchi': [3664], 'Ogasawara': [3666], 'Takaoka': [3668], 'Tanaka': [3670], 'Annu': [3672], 'Rev': [3673], '623-655Crossref': [3677], '(1297)': [3680], 'next': [3691], 'tested': [3692, 4292], 'significance': [3695, 4099], 'LPS.': [3701], 'promoter-CAT': [3709], 'not': [3713, 4022, 4087, 4109, 4124, 4244, 4296, 4389, 4438, 4480], 'analysis,': [3745], 'respond': [3752], '24Ma': [3776], 'Chow': [3778], 'J.M.': [3779], 'Carra': [3782], 'Gerosa': [3784], 'Wolf': [3786], 'S.F.': [3787], 'Dzialo': [3788], '183:': [3796], '147-157Crossref': [3797], '(586)': [3800], 'utilized.': [3804], 'When': [3805], 'synergistic': [3825, 3862], 'stimulated': [3832], '1B).': [3838, 3874], 'predicted': [3842], '(–62/–57D)': [3846], '(–68/–62D)': [3849], 'diminished': [3850], 'activity.': [3853], 'Significantly,': [3854], 'markedly': [3859], 'attenuated': [3860, 4228, 4423], 'seen': [3865], 'treated': [3868], 'performed.': [3885, 4171], 'Two': [3886], 'complexes,': [3888], 'I': [3889, 4102, 4107, 4144], 'II,': [3891, 4222], 'observed': [3893], '(–77': [3898], '–46': [3900, 4401, 4513], 'site)': [3907], '2A).': [3918], 'II': [3920, 3999, 4028, 4067, 4197, 4247, 4299], 'slightly': [3922], 'enhanced': [3923, 3932], 'extracts,': [3929], 'clearly': [3931], 'co-activation': [3937], '2A,': [3939, 3969, 4132], 'lanes': [3940, 3970, 4004, 4031, 4094, 4116, 4133, 4200, 4234, 4251, 4303, 4444], '1–4).': [3941], 'eliminated': [3945], '77/46m,': [3948], 'mutated': [3951], 'correlates': [3958], 'decreased': [3960], 'assays,': [3965], '5–8).': [3971], 'Competition': [3972], 'unlabeled': [3974, 3986, 4112], 'double': [3975], 'stranded': [3976], 'oligonucleotides': [3977, 4011], '100-fold': [3990], 'molar': [3991], 'excess': [3992], 'completely': [3993], 'inhibited': [3994, 4193, 4218], 'formation': [3996, 4025, 4064, 4219, 4248, 4300], '2B,': [4003, 4030, 4093, 4115, 4407, 4443], '3,': [4005], '4,': [4006], '8,': [4007], '9).': [4009, 4119], 'Double-stranded': [4010], 'did': [4021, 4243, 4295, 4437], 'inhibit': [4023], '2,': [4032], '5,': [4033], '7,': [4034], '10).': [4036, 4097], 'results': [4038], 'suggest': [4039, 4141], 'located': [4046], 'roughly': [4052], '–54,': [4056], 'contributes': [4061], 'EMSAs.': [4069], 'This': [4070], 'experiment': [4071], '–62,': [4083], 'although': [4084], 'homologous,': [4085], 'classical': [4089], 'competed': [4110], 'present': [4125, 4397], '77/46m': [4130], '5–8)': [4134], 'EMSA.': [4138], 'finding': [4140], 'represents': [4145], 'abundant': [4147], 'whose': [4152], 'identity': [4153], 'thus': [4155], 'far': [4156], 'unknown.': [4157], 'identify': [4159], 'bind': [4163], 'supershift': [4168], 'NFATc1,': [4174], '-c2,': [4175], '-c4,': [4177], 'recognizing': [4181, 4205], 'c1,': [4185], 'c2,': [4186], 'c3,': [4187], 'c4': [4189], '(αNFATc1;': [4190], 'K18)': [4191], 'supershifted': [4195, 4474], '2C,': [4199, 4233, 4250, 4302], '8–10': [4201], '12).': [4203], 'different': [4206], 'tested.': [4212], 'Interestingly,': [4213], '6': [4235], '7).': [4237], 'affect': [4245, 4297], '5).': [4254], 'Rel': [4257], 'share': [4264], 'similar': [4266], 'domain': [4269], 'anti-c-Rel': [4287], 'antibodies': [4290, 4413, 4431, 4449, 4472], '3).': [4306], 'member': [4310], 'recruit': [4313], 'ICSBP/IRF-4': [4314, 4498], 'PU.1/IRF': [4316], '(25Kim': [4319], 'Y.M.': [4320], 'Kang': [4321], 'H.S.': [4322], 'Paik': [4323], 'S.G.': [4324], 'Pyun': [4325], 'K.H.': [4326], 'Anderson': [4327], 'K.L.': [4328], 'Torbett': [4329], 'B.E.': [4330], 'Choi': [4331], 'I.': [4332], '163:': [4336], '2000-2007PubMed': [4337], '26Rehli': [4340], 'Poltorak': [4342], 'Schwarzfischer': [4344], 'Krause': [4346], 'S.W.': [4347], 'Andreesen': [4348], 'Beutler': [4350], '275:': [4356], '9773-9781Abstract': [4357], '(213)': [4365], '27Marecki': [4368], 'Riendeau': [4370], 'C.J.': [4371], 'Liang': [4372], 'M.D.': [4373], 'Fenton': [4374], 'M.J.': [4375], '166:': [4379], '6829-6838Crossref': [4380], '(98)': [4383], 'component': [4391], '–77': [4399, 4511], 'lane': [4408], '13).': [4409], 'combination': [4411], '(or': [4416], 'NFATc4)': [4419], 'further': [4422], 'II.': [4428], 'together': [4436], '14–18).': [4445], 'test': [4447], 'whether': [4448], 'these': [4456], 'functioned': [4458], 'properly': [4459], 'supershift,': [4461], 'probe.': [4470], 'Both': [4471], '(data': [4479], 'shown).': [4481], 'predominant': [4488], 'bound': [4492, 4508], 'summary,': [4497], 'groups': [4507], 'p4': [4523]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2001617137', 'counts_by_year': [{'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-14T05:12:35.118152', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
