Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2001412153', 'doi': 'https://doi.org/10.2147/dddt.s39449', 'title': 'New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol', 'display_name': 'New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol', 'publication_year': 2013, 'publication_date': '2013-10-01', 'ids': {'openalex': 'https://openalex.org/W2001412153', 'doi': 'https://doi.org/10.2147/dddt.s39449', 'mag': '2001412153', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24143077', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3797618'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/dddt.s39449', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=17779', 'source': {'id': 'https://openalex.org/S2496126384', 'display_name': 'Drug Design Development and Therapy', 'issn_l': '1177-8881', 'issn': ['1177-8881'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.dovepress.com/getfile.php?fileID=17779', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060089859', 'display_name': 'Mario Cazzola', 'orcid': 'https://orcid.org/0000-0003-4895-9707'}, 'institutions': [{'id': 'https://openalex.org/I116067653', 'display_name': 'University of Rome Tor Vergata', 'ror': 'https://ror.org/02p77k626', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I116067653']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mario Cazzola', 'raw_affiliation_strings': ["Department of System Medicine, University of Rome 'Tor Vergata', Rome, Italy."], 'affiliations': [{'raw_affiliation_string': "Department of System Medicine, University of Rome 'Tor Vergata', Rome, Italy.", 'institution_ids': ['https://openalex.org/I116067653']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005227486', 'display_name': 'Andrea Segreti', 'orcid': 'https://orcid.org/0000-0003-2631-8642'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Andrea Segreti', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062907116', 'display_name': 'Maria Gabriella Matera', 'orcid': 'https://orcid.org/0000-0002-5113-9235'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Maria Gabriella Matera', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'apc_paid': {'value': 2836, 'currency': 'USD', 'value_usd': 2836, 'provenance': 'doaj'}, 'fwci': 1.902, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 42, 'citation_normalized_percentile': {'value': 0.573113, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': None, 'issue': None, 'first_page': '1201', 'last_page': '1201'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10143', 'display_name': 'Standardisation and Management of COPD', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10143', 'display_name': 'Standardisation and Management of COPD', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12418', 'display_name': 'Diagnosis and Management of Chronic Cough', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/copd', 'display_name': 'COPD', 'score': 0.506415}], 'concepts': [{'id': 'https://openalex.org/C2776780178', 'wikidata': 'https://www.wikidata.org/wiki/Q199804', 'display_name': 'COPD', 'level': 2, 'score': 0.6849209}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.53430736}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.4119162}, {'id': 'https://openalex.org/C192209626', 'wikidata': 'https://www.wikidata.org/wiki/Q190909', 'display_name': 'Focus (optics)', 'level': 2, 'score': 0.4104281}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20096302}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.062074035}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001592', 'descriptor_name': 'Benzyl Alcohols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D002722', 'descriptor_name': 'Chlorobenzenes', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D011812', 'descriptor_name': 'Quinuclidines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000280', 'descriptor_name': 'Administration, Inhalation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058666', 'descriptor_name': 'Adrenergic beta-2 Receptor Agonists', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D058666', 'descriptor_name': 'Adrenergic beta-2 Receptor Agonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D058666', 'descriptor_name': 'Adrenergic beta-2 Receptor Agonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D058666', 'descriptor_name': 'Adrenergic beta-2 Receptor Agonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001592', 'descriptor_name': 'Benzyl Alcohols', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001592', 'descriptor_name': 'Benzyl Alcohols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001592', 'descriptor_name': 'Benzyl Alcohols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D001993', 'descriptor_name': 'Bronchodilator Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002722', 'descriptor_name': 'Chlorobenzenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002722', 'descriptor_name': 'Chlorobenzenes', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D002722', 'descriptor_name': 'Chlorobenzenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003692', 'descriptor_name': 'Delayed-Action Preparations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004338', 'descriptor_name': 'Drug Combinations', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005541', 'descriptor_name': 'Forced Expiratory Volume', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018727', 'descriptor_name': 'Muscarinic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018727', 'descriptor_name': 'Muscarinic Antagonists', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D018727', 'descriptor_name': 'Muscarinic Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018727', 'descriptor_name': 'Muscarinic Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D017063', 'descriptor_name': 'Outcome Assessment, Health Care', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D029424', 'descriptor_name': 'Pulmonary Disease, Chronic Obstructive', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011812', 'descriptor_name': 'Quinuclidines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011812', 'descriptor_name': 'Quinuclidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011812', 'descriptor_name': 'Quinuclidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/dddt.s39449', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=17779', 'source': {'id': 'https://openalex.org/S2496126384', 'display_name': 'Drug Design Development and Therapy', 'issn_l': '1177-8881', 'issn': ['1177-8881'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/10e44ad9379344aaae7c8dee18cc06b5', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3797618', 'pdf_url': 'https://europepmc.org/articles/pmc3797618?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797618', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24143077', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2147/dddt.s39449', 'pdf_url': 'https://www.dovepress.com/getfile.php?fileID=17779', 'source': {'id': 'https://openalex.org/S2496126384', 'display_name': 'Drug Design Development and Therapy', 'issn_l': '1177-8881', 'issn': ['1177-8881'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320348', 'host_organization_name': 'Dove Medical Press', 'host_organization_lineage': ['https://openalex.org/P4310320348'], 'host_organization_lineage_names': ['Dove Medical Press'], 'type': 'journal'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.83, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1479859260', 'https://openalex.org/W1484046730', 'https://openalex.org/W1963547474', 'https://openalex.org/W1963720710', 'https://openalex.org/W1967698544', 'https://openalex.org/W1973217968', 'https://openalex.org/W1974914274', 'https://openalex.org/W1978690806', 'https://openalex.org/W1997210895', 'https://openalex.org/W1999225686', 'https://openalex.org/W2003293665', 'https://openalex.org/W2014443443', 'https://openalex.org/W2020598205', 'https://openalex.org/W2026835257', 'https://openalex.org/W2032257275', 'https://openalex.org/W2039237831', 'https://openalex.org/W2047474767', 'https://openalex.org/W2055536486', 'https://openalex.org/W2057335633', 'https://openalex.org/W2064278699', 'https://openalex.org/W2066616351', 'https://openalex.org/W2073529780', 'https://openalex.org/W2075148927', 'https://openalex.org/W2081271598', 'https://openalex.org/W2083230284', 'https://openalex.org/W2093096570', 'https://openalex.org/W2102367871', 'https://openalex.org/W2102590607', 'https://openalex.org/W2109593534', 'https://openalex.org/W2120142102', 'https://openalex.org/W2122286642', 'https://openalex.org/W2123850585', 'https://openalex.org/W2127951128', 'https://openalex.org/W2142627051', 'https://openalex.org/W2146877487', 'https://openalex.org/W2160856181', 'https://openalex.org/W2171960654', 'https://openalex.org/W2171974699'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'An': [0, 68], 'increasing': [1], 'body': [2], 'of': [3, 33, 48, 72, 94, 119], 'evidence': [4], 'suggests': [5, 105], 'that': [6, 29, 53, 106, 155], 'the': [7, 46, 76, 80, 117, 135], 'long-acting': [8], 'muscarinic': [9], 'antagonist': [10], '(LAMA)/long-acting': [11], 'β2-agonist': [12], '(LABA)': [13], 'combination': [14, 71, 115], 'appears': [15], 'to': [16, 26, 45, 124, 158], 'play': [17], 'an': [18, 109], 'important': [19, 157], 'role': [20], 'in': [21, 37, 41, 59, 116, 151], 'maximizing': [22], 'bronchodilation,': [23], 'with': [24, 61, 131, 149], 'studies': [25], 'date': [27], 'indicating': [28], 'combining': [30], 'different': [31], 'classes': [32], 'bronchodilators': [34], 'may': [35], 'result': [36], 'significantly': [38, 143], 'greater': [39], 'improvements': [40, 150], 'lung': [42], 'function': [43], 'compared': [44], 'use': [47], 'a': [49, 87], 'single': [50], 'drug,': [51], 'and': [52, 79], 'these': [54], 'combinations': [55], 'are': [56, 156], 'well': [57], 'tolerated': [58], 'patients': [60], 'moderate-to-severe': [62], 'chronic': [63], 'obstructive': [64], 'pulmonary': [65], 'disease': [66], '(COPD).': [67], 'inhaled,': [69], 'fixed-dose': [70, 114, 140], 'two': [73], '24-hour': [74], 'bronchodilators,': [75], 'LAMA': [77], 'umeclidinium': [78], 'LABA': [81], 'vilanterol,': [82], 'is': [83, 108, 146], 'under': [84], 'development': [85], 'as': [86], 'once-daily': [88, 111], 'treatment': [89, 118], 'for': [90], 'COPD.': [91, 120], 'The': [92, 101], 'efficacy': [93], 'both': [95], 'mono-components': [96], 'has': [97], 'already': [98], 'been': [99], 'demonstrated.': [100], 'information': [102], 'currently': [103], 'available': [104], 'umeclidinium/vilanterol': [107, 139], 'effective': [110], 'dual': [112], 'bronchodilator': [113], 'However,': [121], 'it': [122, 128], 'remains': [123, 137], 'be': [125], 'seen': [126], 'if': [127], 'compares': [129], 'favorably': [130], 'current': [132], 'therapies.': [133], 'Moreover,': [134], 'question': [136], 'whether': [138], 'combination,': [141], 'which': [142], 'improves': [144], 'FEV1,': [145], 'also': [147], 'associated': [148], 'other': [152], 'outcome': [153], 'measures': [154], 'COPD': [159], 'patients.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2001412153', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 11}], 'updated_date': '2024-09-19T22:50:45.801516', 'created_date': '2016-06-24'}