Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2001286107', 'doi': 'https://doi.org/10.1083/jcb.200406140', 'title': 'Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis', 'display_name': 'Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis', 'publication_year': 2004, 'publication_date': '2004-10-18', 'ids': {'openalex': 'https://openalex.org/W2001286107', 'doi': 'https://doi.org/10.1083/jcb.200406140', 'mag': '2001286107', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15492044', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2172557'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200406140', 'pdf_url': 'http://jcb.rupress.org/content/167/2/215.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://jcb.rupress.org/content/167/2/215.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5050624977', 'display_name': 'Salvatore Pece', 'orcid': 'https://orcid.org/0000-0003-1764-3929'}, 'institutions': [{'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Salvatore Pece', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy', '2Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '2Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943']}, {'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003851233', 'display_name': 'Michela Serresi', 'orcid': 'https://orcid.org/0000-0001-6839-8658'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Michela Serresi', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054099288', 'display_name': 'E Santolini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elisa Santolini', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061750256', 'display_name': 'Maria Capra', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I4210127391', 'display_name': 'Italian Association for Cancer Research', 'ror': 'https://ror.org/02g2x7380', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210127391']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Maria Capra', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy', '3Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}, {'raw_affiliation_string': '3Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy', 'institution_ids': ['https://openalex.org/I4210127391']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071910855', 'display_name': 'Esther Hulleman', 'orcid': 'https://orcid.org/0000-0001-9256-947X'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Esther Hulleman', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026437921', 'display_name': 'Viviana Galimberti', 'orcid': 'https://orcid.org/0000-0002-5036-7439'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Viviana Galimberti', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064438542', 'display_name': 'Stefano Zurrida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Stefano Zurrida', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013117107', 'display_name': 'Patrick Maisonneuve', 'orcid': 'https://orcid.org/0000-0002-5309-4704'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Patrick Maisonneuve', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088697304', 'display_name': 'Giuseppe Viale', 'orcid': 'https://orcid.org/0000-0003-1882-7068'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giuseppe Viale', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy', '2Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}, {'raw_affiliation_string': '2Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034358950', 'display_name': 'Pier Paolo Di Fiore', 'orcid': 'https://orcid.org/0000-0002-2252-0950'}, 'institutions': [{'id': 'https://openalex.org/I6141010', 'display_name': 'European Institute of Oncology', 'ror': 'https://ror.org/02vr0ne26', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153126', 'https://openalex.org/I6141010']}, {'id': 'https://openalex.org/I189158943', 'display_name': 'University of Milan', 'ror': 'https://ror.org/00wjc7c48', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I189158943']}, {'id': 'https://openalex.org/I4210127391', 'display_name': 'Italian Association for Cancer Research', 'ror': 'https://ror.org/02g2x7380', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210127391']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Pier Paolo Di Fiore', 'raw_affiliation_strings': ['1Istituto Europeo di Oncologia, 20141 Milan, Italy', '2Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy', '3Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy'], 'affiliations': [{'raw_affiliation_string': '1Istituto Europeo di Oncologia, 20141 Milan, Italy', 'institution_ids': ['https://openalex.org/I6141010']}, {'raw_affiliation_string': '2Dipartimento di Medicina, Chirurgia ed Odontoiatria, Università degli Studi di Milano, 20122 Milan, Italy', 'institution_ids': ['https://openalex.org/I189158943']}, {'raw_affiliation_string': '3Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, 20139 Milan, Italy', 'institution_ids': ['https://openalex.org/I4210127391']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.103, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 472, 'citation_normalized_percentile': {'value': 0.999979, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '167', 'issue': '2', 'first_page': '215', 'last_page': '221'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10268', 'display_name': 'Notch Signaling Pathway in Development and Disease', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling in Development and Cancer', 'score': 0.9744, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10929', 'display_name': 'Wnt Signaling in Development and Disease', 'score': 0.9305, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/numb', 'display_name': 'NUMB', 'score': 0.9963505}, {'id': 'https://openalex.org/keywords/notch-signaling', 'display_name': 'Notch Signaling', 'score': 0.597907}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.502092}, {'id': 'https://openalex.org/keywords/hes3-signaling-axis', 'display_name': 'Hes3 signaling axis', 'score': 0.45762476}], 'concepts': [{'id': 'https://openalex.org/C2776746469', 'wikidata': 'https://www.wikidata.org/wiki/Q18033185', 'display_name': 'NUMB', 'level': 2, 'score': 0.9963505}, {'id': 'https://openalex.org/C161879069', 'wikidata': 'https://www.wikidata.org/wiki/Q904082', 'display_name': 'Notch signaling pathway', 'level': 3, 'score': 0.9140954}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.77856266}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.55034894}, {'id': 'https://openalex.org/C555283112', 'wikidata': 'https://www.wikidata.org/wiki/Q1637543', 'display_name': 'Carcinogenesis', 'level': 3, 'score': 0.5208303}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49856663}, {'id': 'https://openalex.org/C65114990', 'wikidata': 'https://www.wikidata.org/wiki/Q5745269', 'display_name': 'Hes3 signaling axis', 'level': 4, 'score': 0.45762476}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.357336}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.35164517}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.104391515}], 'mesh': [{'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007605', 'descriptor_name': 'Juvenile Hormones', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029721', 'descriptor_name': 'Drosophila Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017930', 'descriptor_name': 'Genes, Reporter', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D049452', 'descriptor_name': 'Green Fluorescent Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007091', 'descriptor_name': 'Image Processing, Computer-Assisted', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017403', 'descriptor_name': 'In Situ Hybridization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007605', 'descriptor_name': 'Juvenile Hormones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007605', 'descriptor_name': 'Juvenile Hormones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019656', 'descriptor_name': 'Loss of Heterozygosity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008156', 'descriptor_name': 'Luciferases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008565', 'descriptor_name': 'Membrane Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008856', 'descriptor_name': 'Microscopy, Fluorescence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034741', 'descriptor_name': 'RNA, Small Interfering', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051880', 'descriptor_name': 'Receptors, Notch', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025801', 'descriptor_name': 'Ubiquitin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200406140', 'pdf_url': 'http://jcb.rupress.org/content/167/2/215.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2172557', 'pdf_url': 'https://europepmc.org/articles/pmc2172557?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172557', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15492044', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1083/jcb.200406140', 'pdf_url': 'http://jcb.rupress.org/content/167/2/215.full.pdf', 'source': {'id': 'https://openalex.org/S96410829', 'display_name': 'The Journal of Cell Biology', 'issn_l': '0021-9525', 'issn': ['0021-9525', '1540-8140'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.67, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 26, 'referenced_works': ['https://openalex.org/W1660631781', 'https://openalex.org/W1814546794', 'https://openalex.org/W1832030339', 'https://openalex.org/W1995714285', 'https://openalex.org/W2018527149', 'https://openalex.org/W2020333197', 'https://openalex.org/W2025804504', 'https://openalex.org/W2028480293', 'https://openalex.org/W2037914683', 'https://openalex.org/W2063733034', 'https://openalex.org/W2075947758', 'https://openalex.org/W2088539039', 'https://openalex.org/W2095666604', 'https://openalex.org/W2127125400', 'https://openalex.org/W2129124160', 'https://openalex.org/W2132884452', 'https://openalex.org/W2136188534', 'https://openalex.org/W2138077682', 'https://openalex.org/W2141236652', 'https://openalex.org/W2149746235', 'https://openalex.org/W2151727461', 'https://openalex.org/W2153371646', 'https://openalex.org/W2154115093', 'https://openalex.org/W2154861644', 'https://openalex.org/W2158341017', 'https://openalex.org/W2160455157'], 'related_works': ['https://openalex.org/W2889839847', 'https://openalex.org/W2488182318', 'https://openalex.org/W2385477709', 'https://openalex.org/W2379182815', 'https://openalex.org/W2045791261', 'https://openalex.org/W2016099927', 'https://openalex.org/W1991523935', 'https://openalex.org/W1990534862', 'https://openalex.org/W1985782363', 'https://openalex.org/W1978215356'], 'abstract_inverted_index': {'The': [0], 'biological': [1, 139], 'antagonism': [2, 140], 'between': [3], 'Notch': [4, 17, 33, 47, 86, 107], 'and': [5, 13, 62, 113, 151], 'Numb': [6, 60, 66, 104], 'controls': [7], 'the': [8, 137, 144, 147], 'proliferative/differentiative': [9], 'balance': [10], 'in': [11, 34, 51, 75, 79, 90, 109, 114], 'development': [12], 'homeostasis.': [14], 'Although': [15], 'altered': [16], 'signaling': [18, 48, 87, 108], 'has': [19, 37], 'been': [20], 'linked': [21], 'to': [22, 58, 95, 143, 155], 'human': [23, 35, 54, 156], 'diseases,': [24], 'including': [25], 'cancer,': [26], 'evidence': [27], 'for': [28], 'a': [29], 'substantial': [30], 'involvement': [31], 'of': [32, 53, 101, 121, 134, 146], 'tumors': [36, 127], 'remained': [38], 'elusive.': [39], 'Here,': [40], 'we': [41], 'show': [42], 'that': [43], 'Numb-mediated': [44], 'control': [45], 'on': [46], 'is': [49, 88, 141], 'lost': [50], '∼50%': [52], 'mammary': [55, 149, 157], 'carcinomas,': [56], 'due': [57], 'specific': [59], 'ubiquitination': [61], 'proteasomal': [63], 'degradation.': [64], 'Mechanistically,': [65], 'operates': [67], 'as': [68, 71], 'an': [69], 'oncosuppressor,': [70], 'its': [72, 152], 'ectopic': [73], 'expression': [74, 100], 'Numb-negative,': [76, 122], 'but': [77, 93, 123], 'not': [78, 124], 'Numb-positive,': [80, 125], 'tumor': [81], 'cells': [82, 112], 'inhibits': [83], 'proliferation.': [84], 'Increased': [85], 'observed': [89], 'Numb-negative': [91], 'tumors,': [92], 'reverts': [94], 'basal': [96], 'levels': [97], 'after': [98], 'enforced': [99], 'Numb.': [102], 'Conversely,': [103], 'silencing': [105], 'increases': [106], 'normal': [110, 148], 'breast': [111, 116, 126], 'Numb-positive': [115], 'tumors.': [117], 'Finally,': [118], 'growth': [119], 'suppression': [120], 'can': [128], 'be': [129], 'achieved': [130], 'by': [131], 'pharmacological': [132], 'inhibition': [133], 'Notch.': [135], 'Thus,': [136], 'Numb/Notch': [138], 'relevant': [142], 'homeostasis': [145], 'parenchyma': [150], 'subversion': [153], 'contributes': [154], 'carcinogenesis.': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2001286107', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 25}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 24}, {'year': 2013, 'cited_by_count': 31}, {'year': 2012, 'cited_by_count': 37}], 'updated_date': '2024-09-13T15:15:53.079577', 'created_date': '2016-06-24'}