Publication Information

{'id': 'https://openalex.org/W2001276434', 'doi': 'https://doi.org/10.1074/jbc.m305063200', 'title': 'Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability', 'display_name': 'Modulation of Pro-survival Akt/Protein Kinase B and ERK1/2 Signaling Cascades by Quercetin and Its in Vivo Metabolites Underlie Their Action on Neuronal Viability', 'publication_year': 2003, 'publication_date': '2003-09-01', 'ids': {'openalex': 'https://openalex.org/W2001276434', 'doi': 'https://doi.org/10.1074/jbc.m305063200', 'mag': '2001276434', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12826665'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305063200', 'pdf_url': 'http://www.jbc.org/article/S0021925820835297/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820835297/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111830593', 'display_name': 'Jeremy P. E. Spencer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153400', 'display_name': "King's College Hospital", 'ror': 'https://ror.org/044nptt90', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210111135', 'https://openalex.org/I4210153400']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jeremy P.E. Spencer', 'raw_affiliation_strings': ["Wolfson Centre for Age-related Diseases, Guy's, King's and St. Thomas' School of Biomedical Sciences, Hodgkin Building, King's College, Guy's Campus, London, SE1 9RT, United Kingdom."], 'affiliations': [{'raw_affiliation_string': "Wolfson Centre for Age-related Diseases, Guy's, King's and St. Thomas' School of Biomedical Sciences, Hodgkin Building, King's College, Guy's Campus, London, SE1 9RT, United Kingdom.", 'institution_ids': ['https://openalex.org/I4210153400']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081513258', 'display_name': 'Catherine Rice‐Evans', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Catherine Rice-Evans', 'raw_affiliation_strings': ['King ‘s College London'], 'affiliations': [{'raw_affiliation_string': 'King ‘s College London', 'institution_ids': ['https://openalex.org/I183935753']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101624467', 'display_name': 'Robert J. Williams', 'orcid': 'https://orcid.org/0000-0002-2369-1989'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Robert J. Williams', 'raw_affiliation_strings': ['King ‘s College London'], 'affiliations': [{'raw_affiliation_string': 'King ‘s College London', 'institution_ids': ['https://openalex.org/I183935753']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.254, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 349, 'citation_normalized_percentile': {'value': 0.999843, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '278', 'issue': '37', 'first_page': '34783', 'last_page': '34793'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13991', 'display_name': 'Nuclear Receptors and Signaling', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11332', 'display_name': 'Genomics, phytochemicals, and oxidative stress', 'score': 0.9904, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.8758407}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.6867854}, {'id': 'https://openalex.org/C57074206', 'wikidata': 'https://www.wikidata.org/wiki/Q14197552', 'display_name': 'MAPK/ERK pathway', 'level': 3, 'score': 0.5515249}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.5480736}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5370103}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.5234472}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.51279455}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4535665}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.45032895}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.43407658}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.34402454}], 'mesh': [{'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011794', 'descriptor_name': 'Quercetin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002540', 'descriptor_name': 'Cerebral Cortex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051057', 'descriptor_name': 'Proto-Oncogene Proteins c-akt', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011794', 'descriptor_name': 'Quercetin', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': False}, {'descriptor_ui': 'D011794', 'descriptor_name': 'Quercetin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305063200', 'pdf_url': 'http://www.jbc.org/article/S0021925820835297/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12826665', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305063200', 'pdf_url': 'http://www.jbc.org/article/S0021925820835297/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.52, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 65, 'referenced_works': ['https://openalex.org/W1492349549', 'https://openalex.org/W1529396499', 'https://openalex.org/W1540436551', 'https://openalex.org/W1564588342', 'https://openalex.org/W1660445216', 'https://openalex.org/W1791888878', 'https://openalex.org/W1824652155', 'https://openalex.org/W1971305021', 'https://openalex.org/W1972899454', 'https://openalex.org/W1973668297', 'https://openalex.org/W1975672084', 'https://openalex.org/W1976441097', 'https://openalex.org/W1977101823', 'https://openalex.org/W1980790707', 'https://openalex.org/W1981969869', 'https://openalex.org/W1984547206', 'https://openalex.org/W1986463236', 'https://openalex.org/W1992377755', 'https://openalex.org/W2000413909', 'https://openalex.org/W2008750119', 'https://openalex.org/W2015004507', 'https://openalex.org/W2025148864', 'https://openalex.org/W2026824792', 'https://openalex.org/W2028407281', 'https://openalex.org/W2030573603', 'https://openalex.org/W2041421828', 'https://openalex.org/W2053252892', 'https://openalex.org/W2054632770', 'https://openalex.org/W2056260693', 'https://openalex.org/W2061482527', 'https://openalex.org/W2068569457', 'https://openalex.org/W2068954050', 'https://openalex.org/W2069551285', 'https://openalex.org/W2069941772', 'https://openalex.org/W2071103751', 'https://openalex.org/W2076485183', 'https://openalex.org/W2081705668', 'https://openalex.org/W2083592534', 'https://openalex.org/W2086255122', 'https://openalex.org/W2086959952', 'https://openalex.org/W2089843998', 'https://openalex.org/W2090393867', 'https://openalex.org/W2093628776', 'https://openalex.org/W2094155854', 'https://openalex.org/W2097767970', 'https://openalex.org/W2099000660', 'https://openalex.org/W2099821002', 'https://openalex.org/W2101979944', 'https://openalex.org/W2113686815', 'https://openalex.org/W2114535173', 'https://openalex.org/W2116899977', 'https://openalex.org/W2124432707', 'https://openalex.org/W2128954527', 'https://openalex.org/W2128960139', 'https://openalex.org/W2131878763', 'https://openalex.org/W2135250775', 'https://openalex.org/W2147114673', 'https://openalex.org/W2152247516', 'https://openalex.org/W2170836456', 'https://openalex.org/W2170891211', 'https://openalex.org/W2238706586', 'https://openalex.org/W2267490940', 'https://openalex.org/W2466506587', 'https://openalex.org/W4243104843', 'https://openalex.org/W50161942'], 'related_works': ['https://openalex.org/W4206939639', 'https://openalex.org/W4205189596', 'https://openalex.org/W3183179750', 'https://openalex.org/W3116479654', 'https://openalex.org/W2982360817', 'https://openalex.org/W2916964185', 'https://openalex.org/W2422815049', 'https://openalex.org/W2098584395', 'https://openalex.org/W2070783513', 'https://openalex.org/W2024933597'], 'abstract_inverted_index': {'Much': [0, 263, 753], 'recent': [1, 264, 1167], 'interest': [2, 265], 'has': [3, 266, 648, 977, 1010, 1169, 1248, 1378, 1475, 1652, 1870, 1920, 4227], 'focused': [4, 267], 'on': [5, 173, 187, 268, 436, 450, 875, 1156, 2054, 2597, 2638, 3142, 3189, 3268, 3390, 3638, 3652, 3677, 4085, 4109], 'the': [6, 19, 28, 109, 131, 166, 244, 257, 269, 282, 291, 372, 394, 429, 507, 520, 544, 552, 636, 642, 759, 775, 948, 1021, 1058, 1064, 1184, 1189, 1386, 1470, 1480, 1586, 1589, 1594, 1630, 1695, 1731, 1736, 1742, 1826, 1829, 1918, 1929, 1932, 2027, 2034, 2037, 2061, 2070, 2237, 2245, 2254, 2347, 2351, 2433, 2457, 2509, 2529, 2540, 2568, 2578, 2591, 2622, 2704, 2761, 2770, 2812, 2820, 2831, 2836, 2866, 2871, 2903, 2930, 2933, 2936, 2952, 2982, 3006, 3038, 3129, 3221, 3226, 3273, 3447, 3471, 3509, 3532, 3546, 3575, 3596, 3601, 3624, 3648, 3664, 3678, 3681, 3691, 3694, 3704, 3727, 3733, 3749, 3820, 3879, 3907, 3914, 3925, 3931, 4061, 4066, 4086, 4094, 4110, 4154, 4165, 4181, 4193, 4203, 4206, 4215, 4248, 4271, 4348], 'potential': [7, 32, 270, 295, 760, 966], 'of': [8, 33, 67, 77, 83, 94, 111, 124, 130, 160, 169, 194, 239, 246, 256, 271, 296, 330, 340, 346, 357, 374, 387, 393, 423, 432, 457, 502, 509, 519, 554, 639, 641, 709, 765, 947, 951, 1063, 1162, 1588, 1622, 1676, 1689, 1694, 1733, 1741, 1746, 1828, 1931, 1977, 1984, 2040, 2060, 2063, 2244, 2253, 2269, 2346, 2361, 2364, 2403, 2408, 2447, 2460, 2511, 2549, 2563, 2588, 2642, 2647, 2753, 2772, 2833, 2907, 2932, 3040, 3042, 3047, 3064, 3071, 3508, 3540, 3573, 3578, 3612, 3680, 3693, 3703, 3732, 3768, 3780, 3787, 3810, 3864, 3870, 3881, 3967, 4064, 4068, 4079, 4090, 4104, 4127, 4156, 4167, 4183, 4205, 4251, 4277, 4360], 'flavonoids': [9, 272], 'to': [10, 91, 119, 150, 212, 222, 273, 354, 382, 413, 475, 485, 698, 757, 981, 1013, 1176, 1238, 1255, 1381, 1478, 1624, 1655, 1684, 1832, 1874, 1877, 1924, 2432, 2490, 2546, 2605, 2756, 2870, 2915, 3037, 3191, 3210, 3277, 3413, 3422, 3432, 3462, 3480, 3789, 3812, 3898, 3913, 4093, 4135, 4188, 4334], 'interact': [11, 274, 2911, 4131], 'with': [12, 18, 275, 281, 863, 881, 1069, 2330, 2334, 2375, 2465, 2535, 2627, 2766, 2912, 3035, 3096, 3124, 3133, 3136, 3327, 3338, 3408, 3515, 3531, 3548, 3558, 3605, 3629, 3764, 3854, 3890, 4054, 4132, 4192, 4209], 'intracellular': [13, 276], 'signaling': [14, 56, 242, 277, 319, 505, 702, 1734, 1867, 2078, 2589], 'pathways': [15, 278], 'such': [16, 157, 279, 420, 770, 1231, 1701, 2068], 'as': [17, 280, 771, 984, 986, 1702, 1990, 2069, 2126, 2275, 2468, 2830, 3107, 3468, 3640, 3737, 3748, 3804, 3837, 3839, 4191, 4286, 4288], 'mitogen-activated': [20, 48, 283, 311, 1498, 1696], 'protein': [21, 49, 284, 312, 704, 1499, 1522, 1697, 1935, 2476, 3218, 3229], 'kinase': [22, 50, 53, 190, 285, 313, 316, 453, 705, 1483, 1523, 1698, 1753], 'cascade.': [23, 286], 'We': [24, 287], 'have': [25, 288, 537, 871, 1656, 2032], 'investigated': [26, 289, 1251, 2033, 2507, 3581], 'whether': [27, 290], 'observed': [29, 292, 1012, 1380, 1873, 3833, 3910, 3920, 4199], 'strong': [30, 81, 128, 158, 293, 344, 391, 421, 2918, 4138], 'neurotoxic': [31, 294, 2038, 4062], 'quercetin': [34, 86, 125, 146, 178, 195, 220, 297, 349, 388, 409, 441, 458, 483, 1009, 1060, 1172, 1473, 1580, 1623, 2041, 2111, 2757, 3790, 3835, 3865, 3891, 3968, 3978, 3995, 4026, 4029, 4034, 4055, 4216, 4335], 'in': [35, 60, 74, 165, 205, 298, 323, 337, 428, 468, 532, 542, 551, 651, 693, 701, 774, 879, 945, 960, 989, 1183, 1188, 1240, 1297, 1385, 1422, 1453, 1597, 1658, 1691, 1754, 1993, 2045, 2058, 2356, 2443, 2776, 2817, 2838, 2865, 3005, 3020, 3025, 3220, 3241, 3294, 3324, 3376, 3403, 3440, 3455, 3458, 3470, 3487, 3529, 3671, 3690, 3784, 3797, 3801, 4052, 4149, 4153, 4164, 4177, 4231, 4246], 'primary': [36, 299, 2055], 'cortical': [37, 300, 2056, 2271, 2482, 4252, 4278], 'neurons': [38, 301, 1878, 1994, 2057, 2272, 2315, 2483, 2541, 2592, 2602, 2623, 2937, 2953, 3130, 3554, 3602, 3788, 3811, 4081, 4106, 4158, 4253, 4279], 'may': [39, 229, 302, 492, 546, 1581, 1704, 1817], 'occur': [40, 303], 'via': [41, 233, 304, 496, 1585], 'specific': [42, 305], 'and': [43, 51, 70, 79, 97, 116, 153, 199, 221, 249, 306, 314, 333, 342, 360, 379, 416, 462, 484, 512, 528, 535, 558, 607, 670, 762, 869, 884, 962, 1026, 1120, 1178, 1187, 1230, 1289, 1417, 1447, 1450, 1526, 1549, 1593, 1629, 1663, 1750, 1865, 1986, 2042, 2052, 2073, 2081, 2104, 2113, 2154, 2168, 2189, 2199, 2216, 2219, 2248, 2265, 2320, 2332, 2369, 2394, 2405, 2421, 2450, 2453, 2472, 2493, 2495, 2514, 2516, 2533, 2539, 2553, 2557, 2609, 2636, 2713, 2758, 2811, 2819, 2849, 2862, 2910, 2944, 2951, 2981, 2988, 2993, 3033, 3049, 3054, 3140, 3154, 3177, 3187, 3215, 3257, 3272, 3405, 3460, 3491, 3523, 3537, 3562, 3591, 3600, 3616, 3620, 3636, 3650, 3663, 3782, 3824, 3841, 3856, 3892, 3900, 3927, 3980, 3991, 4005, 4019, 4032, 4070, 4120, 4130, 4159, 4264, 4343, 4354, 4366], 'sensitive': [44, 307], 'interactions': [45, 308], 'within': [46, 309], 'neuronal': [47, 61, 143, 206, 231, 240, 310, 324, 406, 469, 494, 503, 688, 1755, 1833, 2463, 2564, 2571, 2754, 3065, 3672, 3802, 3830, 3871, 3908, 4001, 4040, 4232, 4244, 4349], 'Akt/protein': [52, 315], 'B': [54, 317], '(PKB)': [55, 318], 'cascades,': [57, 320], 'both': [58, 68, 247, 321, 331, 510, 533, 652, 694, 1072, 1626, 1659], 'implicated': [59, 322], 'apoptosis.': [62, 325], 'Quercetin': [63, 326, 1246, 2266, 3781, 4141], 'induced': [64, 127, 327, 390, 1528, 3867, 3883, 3999, 4038], 'potent': [65, 328], 'inhibition': [66, 110, 238, 245, 329, 373, 501, 508], 'Akt/PKB': [69, 149, 248, 332, 412, 511, 2071], 'ERK': [71, 250, 334, 513, 1869, 1985], 'phosphorylation,': [72, 335], 'resulting': [73, 336, 3689], 'reduced': [75, 338], 'phosphorylation': [76, 96, 113, 339, 359, 376], 'BAD': [78, 341], 'a': [80, 223, 234, 343, 486, 497, 548, 699, 1706, 1751, 2357, 2362, 2444, 2547, 2881, 2917, 2967, 3043, 3078, 3090, 3097, 3295, 3391, 3570, 3583, 3610, 3713, 3765, 3798, 3807, 4137, 4150, 4160, 4281, 4289, 4357], 'activation': [82, 129, 159, 255, 345, 392, 422, 518, 1384, 1628, 1827, 1930, 1976, 1983, 3579], 'caspase-3.': [84, 347, 2082], 'High': [85, 348], 'concentrations': [87, 106, 350, 369], '(30': [88, 351, 4030, 4035, 4261], 'μm)': [89, 108, 352, 371, 2498, 2519, 2612, 2635, 2943, 2948, 3565, 3635, 3792, 3982, 3997, 4031, 4036, 4144, 4339], 'led': [90, 353], 'sustained': [92, 355], 'loss': [93, 356, 4182, 4359], 'Akt': [95, 99, 112, 358, 362, 375, 1987, 2156], 'subsequent': [98, 361], 'cleavage': [100, 363], 'by': [101, 253, 364, 516, 1293, 1529, 2470, 2508, 2652, 2656, 2702, 2714, 2868, 3057, 3069, 3225, 3283, 3320, 3544, 3687, 3806, 4099], 'caspase-3,': [102, 161, 365, 424, 3688], 'whereas': [103, 366, 1008, 1020, 1982, 3994], 'at': [104, 367, 970, 2440, 2823, 2959, 2978, 2986, 2998, 3082, 3200, 3207, 3238, 3316, 3387, 3699, 3706, 3740, 3775, 3834, 3962, 3972, 4042, 4170, 4223], 'lower': [105, 167, 368, 430, 3886], '(<10': [107, 370], 'was': [114, 163, 196, 377, 426, 459, 2124, 2234, 2429, 2505, 2531, 2654, 2815, 2843, 2964, 2976, 2984, 3003, 3067, 3104, 3223, 3291, 3542, 3580, 3598, 3666, 3674, 3709, 3773, 3832, 3849, 3874, 3884, 3919, 3969, 4013, 4022, 4050, 4082, 4107, 4197, 4254, 4356], 'transient': [115, 378], 'eventually': [117, 380], 'returned': [118, 381], 'basal': [120, 383], 'levels.': [121, 384], 'Lower': [122, 385], 'levels': [123, 386], 'also': [126, 389, 755, 978, 1818, 1871, 1921, 2430, 2506, 2574, 3866, 3970, 4037, 4240], 'pro-survival': [132, 395, 1926, 1992, 2066], 'transcription': [133, 396], 'factor': [134, 397], 'cAMP-responsive': [135, 398, 1504, 1933], 'element-binding': [136, 399, 1505, 1934], 'protein,': [137, 400], 'although': [138, 401, 940, 1917, 3847, 4048], 'this': [139, 402, 3848, 4011, 4049, 4224, 4242], 'did': [140, 154, 200, 403, 417, 463, 3958], 'not': [141, 155, 197, 201, 404, 418, 460, 464, 3928, 3959, 4268], 'prevent': [142, 405], 'damage.': [144, 407], 'O-Methylated': [145, 408], 'metabolites': [147, 182, 228, 410, 445, 491, 1180, 1232, 3863], 'inhibited': [148, 411], 'lesser': [151, 224, 414, 487], 'extent': [152, 225, 415, 488], 'induce': [156, 230, 419, 493, 1290, 1382, 1448, 3960], 'which': [162, 425, 866, 1692, 3016, 3697], 'reflected': [164, 427], 'amount': [168, 431, 3880], 'damage': [170, 433, 2572, 2650, 3066, 3803, 3882, 4021, 4196, 4245], 'they': [171, 434], 'inflicted': [172, 435], 'neurons.': [174, 214, 437, 477], 'In': [175, 438, 2026, 2566, 3569, 4368], 'contrast,': [176, 439], 'neither': [177, 440], 'nor': [179, 442], 'its': [180, 210, 226, 443, 473, 489, 1073, 1160, 1253, 2043, 2759], 'O-methylated': [181, 227, 444, 490, 1177, 3862], 'had': [183, 446, 2326], 'any': [184, 203, 447, 466, 1244, 3963], 'measurable': [185, 448], 'effect': [186, 449], 'c-Jun': [188, 258, 451, 521, 1481, 1490], 'N-terminal': [189, 259, 452, 522, 1482, 1491], 'phosphorylation.': [191, 454], 'The': [192, 455, 1620, 1673, 2147, 2314, 2436, 2502, 2601, 2826, 2962, 2974, 3045, 3061, 3085, 3182, 3196, 3217, 3231, 3261, 3288, 3333, 3395, 3476, 3493, 3505, 3534, 3643, 3770, 3860, 3965, 4077, 4102, 4175], 'glucuronide': [193, 456, 1179], 'toxic': [198, 461, 967, 1674], 'evoke': [202, 465, 1582], 'alterations': [204, 467], 'signaling,': [207, 470], 'probably': [208, 471], 'reflecting': [209, 472], 'inability': [211, 474], 'enter': [213, 476], 'Together': [215, 478], 'these': [216, 479], 'data': [217, 480, 3011, 3030, 3734, 3745], 'suggest': [218, 481], 'that': [219, 482, 539, 1171, 2325, 2877, 3526, 3873, 3888, 4112, 4222, 4247], 'death': [232, 261, 495, 524, 689, 1291, 1690], 'mechanism': [235, 498, 1161, 1296], 'involving': [236, 499], 'an': [237, 254, 500, 517, 1294, 1686, 1975, 3021, 3488, 3758, 3868], 'survival': [241, 504, 1756, 2842], 'through': [243, 506, 703, 1735, 1868, 1928, 2079], 'rather': [251, 514], 'than': [252, 515, 3887], 'kinase-mediated': [260, 523], 'pathway.': [262, 525], 'Recent': [526], 'epidemiological': [527], 'dietary': [529], 'intervention': [530], 'studies': [531], 'humans': [534], 'animals': [536], 'suggested': [538], 'diet-derived': [540], 'phenolics,': [541], 'particular': [543], 'flavonoids,': [545, 645, 952, 1068, 1681], 'play': [547, 1705], 'beneficial': [549, 761, 873, 949, 1074], 'role': [550, 1707], 'prevention': [553], 'neurodegeneration,': [555], 'age-related': [556, 882], 'cognitive': [557], 'motor': [559], 'decline': [560, 2837], '(1Joseph': [561], 'J.A.': [562, 584, 1321], 'Shukitt-Hale': [563, 585], 'B.': [564, 586, 616, 1128, 1260, 1524], 'Denisova': [565, 587], 'N.A.': [566, 588], 'Bielinski': [567], 'D.': [568, 1357], 'Martin': [569, 593], 'A.': [570, 594, 801, 833, 852, 894, 913, 1126, 1312, 1760, 1954, 1956, 2013], 'McEwen': [571], 'J.J.': [572, 790], 'Bickford': [573, 597], 'P.C.': [574, 598], 'J.': [575, 599, 681, 737, 816, 999, 1041, 1110, 1124, 1130, 1132, 1219, 1339, 1432, 1563, 1644, 1776, 1780, 1809, 1901, 1943, 2138, 2287, 2304, 2669, 2723, 2742, 3116, 4300, 4318], 'Neurosci.': [576, 600, 1810, 3117], '1999;': [577, 1112, 1136, 1205, 1222, 1407, 1434, 1566, 1646, 1765, 1966, 2018, 3118], '19:': [578, 1342, 3119], '8114-8121Crossref': [579], 'PubMed': [580, 604, 629, 665, 685, 724, 748, 805, 821, 856, 917, 1003, 1052, 1088, 1115, 1208, 1225, 1272, 1284, 1370, 1410, 1442, 1464, 1544, 1574, 1615, 1649, 1725, 1768, 1784, 1800, 1814, 1846, 1860, 1912, 1948, 1969, 2005, 2021, 2142, 2291, 2309, 2673, 2697, 2728, 2746, 3121, 4305, 4323], 'Google': [581, 605, 632, 668, 686, 727, 751, 808, 824, 859, 920, 937, 1006, 1055, 1091, 1118, 1139, 1154, 1211, 1228, 1275, 1287, 1318, 1344, 1373, 1413, 1445, 1467, 1547, 1577, 1618, 1650, 1728, 1771, 1787, 1803, 1815, 1849, 1863, 1915, 1951, 1972, 2008, 2024, 2145, 2294, 2312, 2676, 2700, 2731, 2749, 3122, 4308, 4326], 'Scholar,': [582, 728, 809, 825, 921, 1092, 1140, 1212, 1276, 1319, 1345, 1772, 1788, 1804, 1850, 1952, 2009, 2295, 2677, 2732, 4309], '2Joseph': [583], 'Prior': [589], 'R.L.': [590], 'Cao': [591], 'G.': [592, 596, 786, 1194, 1264, 1398, 1402, 1890, 2685], 'Taglialatela': [595], '1998;': [601, 626, 1781, 1811, 2306, 4320], '18:': [602, 1812], '8047-8055Crossref': [603], 'Scholar),': [606, 1007, 1229, 1414, 1446, 1816, 1864, 1916, 2701], 'brain': [608, 876], 'ischemia/reperfusion': [609], 'injury': [610, 3831, 3909, 4002, 4041], '(3Inanami': [611], 'O.': [612, 993], 'Watanabe': [613], 'Y.': [614, 673, 730, 827, 888, 1076, 1094, 1100, 1102, 1142, 1306, 1351, 1556, 1558, 1560, 1602, 1882], 'Syuto': [615], 'Nakano': [617], 'M.': [618, 620, 622, 923, 930, 1098, 1104, 1365, 1392, 1539, 1554, 1604, 1880, 2301, 4315], 'Tsuji': [619], 'Kuwabara': [621], 'Free': [623, 2690], 'Radical': [624, 2691], 'Res.': [625, 1084, 1150, 1314], '29:': [627], '359-365Crossref': [628], 'Scopus': [630, 666, 725, 749, 806, 822, 857, 918, 1004, 1053, 1089, 1116, 1209, 1226, 1273, 1285, 1371, 1411, 1443, 1465, 1545, 1575, 1616, 1726, 1769, 1785, 1801, 1847, 1861, 1913, 1949, 1970, 2006, 2022, 2143, 2292, 2310, 2674, 2698, 2729, 2747, 4306, 4324], '(140)': [631], 'Scholar).': [633, 752, 860, 938, 1056, 1374, 1468, 1578, 1619, 1729, 1973, 2025, 2146, 2313, 2750], 'For': [634, 973, 1375, 2586, 3976], 'example,': [635, 1376, 3977], 'neuroprotective': [637], 'action': [638, 1163], 'one': [640, 1062, 1740], 'green': [643, 2872, 2883, 4095], 'tea': [644], 'epigallocatechin': [646, 975], 'gallate,': [647], 'been': [649, 979, 1011, 1249, 1379, 1476, 1653, 1872, 1922, 2327, 4228], 'shown': [650, 980, 1170, 1477, 1654, 1923], 'oxidative': [653], 'stress-': [654], '(4Kaplan': [655, 714, 1995], 'D.R.': [656, 715, 1792, 1996], 'Miller': [657, 716, 1997], 'F.D.': [658, 717, 1790, 1998], 'Curr.': [659, 718, 1999], 'Opin.': [660, 719, 2000], 'Neurobiol.': [661, 720, 1720, 1856, 2001], '2000;': [662, 721, 818, 1151, 1367, 1607, 1838, 1857, 1904, 2002], '10:': [663, 722, 2003], '381-391Crossref': [664, 723, 2004], '(1670)': [667, 726, 2007], 'Scholar)': [669, 687, 1119, 1155, 1288, 1548, 1651, 3123, 4327], 'Aβ-induced': [671, 1018], '(5Levites': [672], 'Amit': [674, 731], 'T.': [675, 732, 1218, 1562, 1854], 'Mandel': [676, 735, 994], 'S.': [677, 736, 782, 800, 811, 851, 912, 995, 1096, 1636, 1888, 1940, 2297, 2720, 4297, 4311], 'Youdim': [678, 733, 996], 'M.B.': [679, 734, 997], 'FASEB': [680, 998], '2003;': [682, 1000, 2139], '17:': [683, 1001], '952-954Crossref': [684], 'models.': [690], 'Protective': [691], 'effects': [692, 764, 874, 969, 988, 1122, 1258, 1584, 1675, 2039], 'systems': [695], 'were': [696, 2086, 2116, 2150, 2221, 2243, 2257, 2273, 2316, 2353, 2438, 2462, 2488, 2542, 2573, 2595, 2603, 2624, 2763, 2809, 2828, 2938, 2949, 2954, 3017, 3031, 3052, 3087, 3131, 3185, 3198, 3233, 3266, 3275, 3335, 3397, 3449, 3478, 3495, 3511, 3527, 3556, 3603, 3626, 3645, 3724, 3755, 4073], 'linked': [697], 'modulation': [700, 708, 1732], 'C': [706], 'and/or': [707], 'cell': [710, 1158, 1299, 1388, 3213, 4284, 4350], 'survival/cell': [711], 'cycle': [712], 'genes': [713], '6Levites': [729], 'Biol.': [738, 933, 1042, 1564, 1902, 2692], 'Chem.': [739, 1043, 1565, 1903], '2002;': [740, 853, 914, 934, 1541, 1722, 1945, 2725, 4302], '277:': [741, 1647], '30574-30580Abstract': [742], 'Full': [743, 745, 1047, 1049, 1437, 1439, 1569, 1571, 1610, 1612, 1841, 1843, 1907, 1909], 'Text': [744, 746, 1048, 1050, 1438, 1440, 1570, 1572, 1611, 1613, 1842, 1844, 1908, 1910], 'PDF': [747, 1051, 1441, 1573, 1614, 1845, 1911], '(396)': [750], 'evidence': [754, 944, 1070, 1168, 1824], 'exists': [756], 'support': [758], 'neuromodulatory': [763], 'flavonoid-rich': [766], 'ginkgo': [767], 'biloba': [768], 'extracts,': [769], 'EGb': [772, 864], '761,': [773, 865], 'central': [776], 'nervous': [777], 'system': [778], '(7Watanabe': [779], 'C.M.': [780, 1327], 'Wolffram': [781], 'Ader': [783], 'P.': [784, 845, 906, 1148, 1400], 'Rimbach': [785], 'Packer': [787, 1641], 'L.': [788, 1106, 1533, 1642], 'Maguire': [789], 'Schultz': [791], 'P.G.': [792], 'Gohil': [793], 'K.': [794, 1082, 1108, 1146, 1310, 1347, 1355, 1535, 1552, 1852], 'Proc.': [795, 846, 907], 'Natl.': [796, 847, 908], 'Acad.': [797, 848, 909], 'Sci.': [798, 849, 910, 1268, 1796], 'U.': [799, 850, 911], '2001;': [802, 1044, 1341, 1797, 2288, 2670, 2694, 2743], '98:': [803], '6577-6580Crossref': [804], '(243)': [807], '8Bastianetto': [810], 'Zheng': [812], 'W.H.': [813], 'Quirion': [814], 'R.': [815, 1196, 1394, 1884], 'Neurochem.': [817, 1944, 2305, 2724, 4301, 4319], '74:': [819], '2268-2277Crossref': [820], '(215)': [823], '9Luo': [826], 'Smith': [828, 889], 'J.V.': [829, 890], 'Paramasivam': [830, 891], 'V.': [831, 892], 'Burdick': [832, 893], 'Curry': [834, 895], 'K.J.': [835, 896], 'Buford': [836, 897], 'J.P.': [837, 898], 'Khan': [838, 899], 'I.': [839, 900, 1396, 1537, 1892], 'Netzer': [840, 901], 'W.J.': [841, 902], 'Xu': [842, 903], 'H.': [843, 904, 1308, 1353, 1359, 1634, 1709, 2279, 2661, 2681, 2734], 'Butko': [844, 905], '99:': [854, 915], '12197-12202Crossref': [855, 916], '(384)': [858, 919], 'Clinical': [861], 'trials': [862], 'contains': [867], 'kaempferol': [868], 'quercetin,': [870, 1677, 2049, 2051, 2491, 2512, 2606, 3559, 3934, 4065], 'indicated': [872], 'function,': [877], 'particularly': [878], 'connection': [880], 'dementias': [883], "Alzheimer's": [885], 'disease': [886], '(9Luo': [887], '10Zimmermann': [922], 'Colciaghi': [924], 'F.': [925, 927], 'Cattabeni': [926], 'Di': [928], 'Luca': [929], 'Cell': [931, 1793, 2263, 2841], 'Mol.': [932, 1794], '48:': [935], '613-623PubMed': [936], 'However,': [939, 3878, 4190], 'there': [941, 953, 4226, 4355], 'is': [942, 954, 1061, 1173, 1822, 1979, 2856, 2863, 2895, 4115], 'growing': [943], 'favor': [946], 'affects': [950], 'still': [955], 'uncertainty': [956], 'about': [957, 964], 'their': [958, 965], 'actions': [959], 'vivo': [961, 1241, 2046], 'concern': [963], 'side': [968], 'higher': [971], 'concentrations.': [972, 3859], 'instance,': [974], 'gallate': [976], 'exert': [982], 'pro-apoptotic': [983], 'well': [985, 3002, 3007, 4287], 'anti-apoptotic': [987, 1583], 'neuroblastoma': [990], 'cells': [991, 1424, 1456, 1600, 2352, 2437, 2461, 2861, 2879, 2899, 2909, 3051, 3184, 3625, 4072, 4119, 4129, 4169, 4179], '(11Weinreb': [992], '935-937Crossref': [1002], '(124)': [1005], 'express': [1014, 1256], 'no': [1015, 4020, 4210, 4229], 'protection': [1016, 1030, 2834], 'against': [1017, 2835], 'neurotoxicity,': [1019], 'structurally': [1022], 'related': [1023], 'flavonols,': [1024], 'apigenin': [1025], 'kaempferol,': [1027], 'expressed': [1028, 2829, 3024, 3747, 3983], 'significant': [1029, 3984, 4000, 4039, 4358], '(12Wang': [1031], 'C.N.': [1032], 'Chi': [1033], 'C.W.': [1034], 'Lin': [1035, 1429], 'Y.L.': [1036], 'Chen': [1037], 'C.F.': [1038], 'Shiao': [1039], 'Y.J.': [1040], '276:': [1045], '5287-5295Abstract': [1046], '(187)': [1054], 'Although': [1057], 'flavonol': [1059], 'most': [1065], 'frequently': [1066], 'researched': [1067], 'for': [1071, 1243, 1252, 2341, 2499, 2520, 2544, 2555, 2570, 2613, 2644, 2956, 2991, 3193, 3204, 3235, 3313, 3400, 3443, 3452, 3465, 3484, 3566, 3588, 3618, 3654, 3793, 3916, 3988, 4145, 4340, 4345], '(13Oyama': [1075], 'Fuchs': [1077], 'P.A.': [1078], 'Katayama': [1079], 'N.': [1080, 1262, 1886], 'Noda': [1081], 'Brain': [1083], '1994;': [1085, 1315], '635:': [1086], '125-129Crossref': [1087], '(211)': [1090], '14Oyama': [1093], 'Noguchi': [1095], 'Nakata': [1097], 'Okada': [1099], 'Yamazaki': [1101], 'Funai': [1103], 'Chikahisa': [1105], 'Kanemaru': [1107], 'Eur.': [1109, 1431], 'Pharmacol.': [1111, 1221], '384:': [1113], '47-52Crossref': [1114], '(58)': [1117], 'deleterious': [1121], '(15Rzymowska': [1123], 'Gawron': [1125], 'Pawlikowska-Pawlega': [1127], 'Jakubowicz-Gil': [1129], 'Wojcierowski': [1131], 'Folia': [1133], 'Histochem.': [1134], 'Cytobiol.': [1135], '37:': [1137], '125-126PubMed': [1138], '16Rong': [1141], 'Yang': [1143], 'E.B.': [1144], 'Zhang': [1145], 'Mack': [1147], 'Anticancer': [1149], '20:': [1152], '4339-4345PubMed': [1153], 'different': [1157], 'types,': [1159], 'remains': [1164], 'unclear.': [1165], 'Furthermore,': [1166, 1579], 'extensively': [1174], 'metabolized': [1175, 2864], 'during': [1181], 'absorption': [1182], 'small': [1185, 4051], 'intestine': [1186], 'liver': [1190], '(17Spencer': [1191], 'J.P.E.': [1192, 1713, 2130, 2281, 2663, 2679, 2736], 'Chowrimootoo': [1193], 'Choudhury': [1195], 'Debnam': [1197], 'E.S.': [1198], 'Srai': [1199], 'S.K.': [1200], 'Rice-Evans': [1201, 1718, 2135, 2282, 2664, 2688, 2737], 'C.': [1202, 1711, 1719, 2136, 2283, 2665, 2689, 2738], 'FEBS': [1203, 1405], 'Lett.': [1204, 1280, 1406, 1460], '458:': [1206], '224-230Crossref': [1207], '(392)': [1210], '18Boulton': [1213], 'D.W.': [1214], 'Walle': [1215, 1217], 'U.K.': [1216], 'Pharm.': [1220], '51:': [1223], '353-359Crossref': [1224], '(121)': [1227], 'should': [1233], 'be': [1234, 1819, 1875, 1925], 'taken': [1235, 2857], 'into': [1236, 2859], 'consideration': [1237], 'provide': [1239], 'relevance': [1242, 1657], 'mechanism.': [1245], 'itself': [1247], 'thoroughly': [1250], 'abilities': [1254], 'anti-proliferative': [1257], '(19Csokay': [1259], 'Prajda': [1261], 'Weber': [1263], 'Olah': [1265], 'E.': [1266, 1717, 1894], 'Life': [1267, 1795], '1997;': [1269], '60:': [1270], '2157-2163Crossref': [1271], '(161)': [1274, 1372], '20Kuo': [1277], 'S.M.': [1278, 1458], 'Cancer': [1279, 1313, 1459], '1996;': [1281, 1461], '110:': [1282, 1462], '41-48Crossref': [1283, 1463], '(274)': [1286, 1466], 'predominantly': [1292], 'apoptotic': [1295, 1687, 2077], 'cancer': [1298, 1455], 'lines': [1300], '(21Wei': [1301], 'Y.Q.': [1302], 'Zhao': [1303], 'X.': [1304], 'Kariya': [1305], 'Fukata': [1307], 'Teshigawara': [1309], 'Uchida': [1311], '54:': [1316], '4952-4957PubMed': [1317], '22Choi': [1320], 'Kim': [1322, 1332], 'J.Y.': [1323, 1325], 'Lee': [1324, 1334, 1336], 'Kang': [1326], 'Kwon': [1328], 'H.J.': [1329], 'Yoo': [1330], 'Y.D.': [1331], 'T.W.': [1333], 'Y.S.': [1335], 'S.J.': [1337], 'Int.': [1338, 1606], 'Oncol.': [1340], '837-844PubMed': [1343], '23Yang': [1346], 'Lamprecht': [1348], 'S.A.': [1349], 'Liu': [1350], 'Shinozaki': [1352], 'Fan': [1354], 'Leung': [1356], 'Newmark': [1358], 'Steele': [1360], 'V.E.': [1361], 'Kelloff': [1362], 'G.J.': [1363], 'Lipkin': [1364], 'Carcino-Genesis.': [1366], '21:': [1368], '1655-1660Crossref': [1369], 'it': [1377], 'caspase-3': [1383, 1416, 2096, 2101, 2106, 3728], 'malignant': [1387], 'line': [1389], 'HPB-ALL': [1390], '(24Russo': [1391], 'Palumbo': [1393], 'Tedesco': [1395], 'Mazzarella': [1397], 'Russo': [1399, 1403], 'Iacomino': [1401], 'G.L.': [1404], '462:': [1408], '322-328Crossref': [1409], '(86)': [1412], 'activate': [1415], 'caspase-9,': [1418], 'release': [1419, 3692], 'cytochrome': [1420], 'c': [1421], 'HL-60': [1423], '(25Wang': [1425], 'I.K.': [1426], 'Lin-Shiau': [1427], 'S.Y.': [1428], 'J.K.': [1430], 'Cancer.': [1433], '35:': [1435], '1517-1525Abstract': [1436], '(448)': [1444], 'chromatin': [1449], 'nuclear': [1451], 'fragmentation': [1452], 'colonic': [1454], '(20Kuo': [1457], 'On': [1469], 'other': [1471, 1680, 2240, 2255], 'hand,': [1472], 'treatment': [1474, 3853, 4208], 'suppress': [1479], '(JNK)': [1484], '1The': [1485], 'abbreviations': [1486], 'used': [1487, 2085, 2149, 2235, 2242], 'are:': [1488], 'JNK,': [1489, 1703], 'kinase;': [1492, 1496, 1500], 'ERK,': [1493], 'extracellular': [1494], 'signal-regulated': [1495], 'MAPK,': [1497], 'PI,': [1501], 'phosphatidylinositol;': [1502], 'CREB,': [1503], 'protein;': [1506], 'MTT,': [1507], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl;': [1508], 'pAb,': [1509, 2164, 2167], 'polyclonal': [1510], 'antibody;': [1511], 'PBS,': [1512, 2629], 'phosphate-buffered': [1513], 'saline;': [1514, 1517], 'TBS,': [1515], 'Tris-buffered': [1516], 'AM,': [1518], 'acetoxymethyl': [1519], 'ester;': [1520], 'PKB,': [1521], 'activity': [1525, 3670], 'apoptosis': [1527, 1834], 'hydrogen': [1530], 'peroxide': [1531], '(26Wang': [1532], 'Matsushita': [1534], 'Araki': [1536], 'Takeda': [1538], 'Nephron.': [1540], '91:': [1542], '142-147Crossref': [1543], '(38)': [1546], '4-hydroxy-2-nonenal': [1550], '(27Uchida': [1551], 'Shiraishi': [1553], 'Naito': [1555], 'Torii': [1557], 'Nakamura': [1559], 'Osawa': [1561], '274:': [1567], '2234-2242Abstract': [1568], '(526)': [1576], 'suppression': [1587], 'peroxide-induced': [1590], 'JyNK-c-Jun/AP-1': [1591], 'pathway': [1592, 1596, 1632, 1831], 'ERK-c-Fos/AP-1': [1595], 'cultured': [1598, 2439], 'mesangial': [1599], '(28Ishikawa': [1601], 'Kitamura': [1603], 'Kidney': [1605], '58:': [1608, 1798], '1078-1087Abstract': [1609], '(188)': [1617], 'ability': [1621, 3809], 'inhibit': [1625], 'AP-1': [1627], 'JNK': [1631, 1830, 1978, 2080, 2191, 3346], '(29Kobuchi': [1633], 'Roy': [1635], 'Sen': [1637], 'C.K.': [1638], 'Nguyen': [1639], 'H.G.': [1640], 'Am.': [1643], 'Physiol.': [1645], 'C403-C411Crossref': [1648], 'phorbol': [1660], '12-myristate': [1661], '13-acetate-': [1662], 'tumor': [1664], 'necrosis': [1665], 'factor-α-induced': [1666], 'intercellular': [1667], 'adhesion': [1668], 'molecule': [1669], '1': [1670, 3165, 3173, 3840], '(ICAM-1)': [1671], 'expression.': [1672], 'or': [1678, 2261, 2523, 2583, 2616, 2706, 3372, 3427, 4337], 'indeed': [1679], 'are': [1682, 1988, 3735, 3746], 'likely': [1683], 'involve': [1685], 'mode': [1688, 3009], 'members': [1693], '(MAPK)': [1699], 'family,': [1700], '(30Schroeter': [1708], 'Boyd': [1710], 'Spencer': [1712, 2280, 2662, 2735], 'Williams': [1714, 1941, 2133, 2284, 2302, 2666, 2686, 2721, 2739, 3114, 4298, 4316], 'R.J.': [1715, 1806, 1836, 1942, 2134, 2285, 2303, 2667, 2687, 2722, 2740, 3115, 4299, 4317], 'Cadenas': [1716], 'Aging.': [1721], '23:': [1723], '861Crossref': [1724], '(291)': [1727], 'Alternatively,': [1730], 'serine/threonine': [1737], 'kinase,': [1738], 'Akt/PKB,': [1739], 'main': [1743], 'downstream': [1744], 'effectors': [1745], 'phosphatidylinositol': [1747], '(PI)': [1748], '3-kinase': [1749], 'pivotal': [1752], '(31Datta': [1757], 'S.R.': [1758, 1960, 2011], 'Brunet': [1759, 1955, 2012], 'Greenberg': [1761, 1963, 2014], 'M.E.': [1762, 1964, 2015], 'Genes': [1763, 2016], 'Dev.': [1764, 2017], '13:': [1766, 2019], '2905-2927Crossref': [1767, 2020], '(3729)': [1770, 2023], '32Coffer': [1773], 'P.J.': [1774], 'Jin': [1775], 'Woodgett': [1777], 'J.R.': [1778], 'Biochem.': [1779, 2137, 2286, 2668, 2741], '335:': [1782], '1-13Crossref': [1783], '(969)': [1786], '33Miller': [1789], 'Kaplan': [1791], '1045-1053Crossref': [1799], '(288)': [1802], '34Crowder': [1805], 'Freeman': [1807], 'R.S.': [1808], '2933-2943Crossref': [1813], 'important.': [1820], 'There': [1821], 'considerable': [1823], 'linking': [1825], '(35Davis': [1835], 'Cell.': [1837], '103:': [1839], '239-252Abstract': [1840], '(3666)': [1848], '36Mielke': [1851], 'Herdegen': [1853], 'Prog.': [1855], '61:': [1858], '45-60Crossref': [1859], '(443)': [1862], 'stress': [1866], 'detrimental': [1876], '(37Stanciu': [1879], 'Wang': [1881], 'Kentor': [1883], 'Burke': [1885], 'Watkins': [1887], 'Kress': [1889], 'Reynolds': [1891], 'Klann': [1893], 'Angiolieri': [1895], 'M.R.': [1896], 'Johnson': [1897], 'J.W.': [1898], 'DeFranco': [1899], 'D.B.': [1900], '275:': [1905], '12200-12206Abstract': [1906], '(488)': [1914], 'latter': [1919], 'partly': [1927], '(CREB)': [1936], '(38Crossthwaite': [1937, 2717, 4294], 'A.J.': [1938, 2683, 2718, 4295], 'Hasan': [1939, 2719, 4296], '80:': [1946, 2726, 4303], '24-35Crossref': [1947, 2727, 4304], '(180)': [1950, 2730, 4307], '39Bonni': [1953], 'West': [1957], 'A.E.': [1958], 'Datta': [1959], 'Takasu': [1961], 'M.A.': [1962], 'Science.': [1965], '286:': [1967], '1358-1362Crossref': [1968], '(1682)': [1971], 'Generally,': [1974], 'considered': [1980], 'pro-apoptotic,': [1981], 'viewed': [1989], 'being': [1991], '31Datta': [2010], 'study': [2028], 'described': [2029, 2127, 2276, 3109, 3469, 3641], 'here,': [2030], 'we': [2031], 'mechanisms': [2035], 'underlying': [2036], 'major': [2044], 'metabolites,': [2047, 2760], '3′-O-methyl': [2048, 2110, 4028], '4′-O-methyl': [2050, 4033], 'quercetin-7-O-β-d-glucuronide,': [2053], 'terms': [2059], 'balance': [2062], 'influence': [2064], 'between': [2065], 'pathways,': [2067, 2075], 'cascade,': [2072], 'pro-death': [2074], 'namely': [2076], 'Materials—Specialized': [2083], 'chemicals': [2084], 'obtained': [2087, 2249, 2258], 'from': [2088, 2118, 2223, 2250, 2259, 2399, 2427, 2897, 3012, 3513, 3647, 4117], 'Sigma:': [2089], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl': [2090], '(MTT),': [2091], 'mammalian': [2092, 3159], 'protease': [2093, 3160, 3669], 'inhibitor': [2094, 3161, 3729], 'mixture,': [2095], 'peptide': [2097, 3682], 'substrate,': [2098], 'acetyl-Asp-Glu-Val-Asp': [2099, 3684], 'p-nitroanilide,': [2100], 'inhibitor,': [2102], 'acetyl-Asp-Glu-Val-Asp-al,': [2103], 'recombinant': [2105], 'positive': [2107], 'control.': [2108, 3044], 'Quercetin,': [2109], '(isorhamnetin)': [2112], '4′-O-methyl-quercetin': [2114, 2494, 2515], '(tamarixetin)': [2115], 'purchased': [2117, 2222], 'Extrasynthese': [2119], '(Genay': [2120], 'Cedex,': [2121], 'France).': [2122], 'Quercetin-O-7-β-d-glucuronide': [2123], 'synthesized': [2125], 'previously': [2128, 2277, 3108], '(40Spencer': [2129], 'Kuhnle': [2131, 2684], 'G.G.': [2132], '372:': [2140], '173-181Crossref': [2141], '(232)': [2144], 'antibodies': [2148], 'anti-phospho-Akt': [2151, 2162, 3349, 3353], '(Ser473)': [2152, 3350], 'pAb': [2153, 2157, 2180, 2188, 2192, 2198, 2202, 3342, 3347, 3351, 3355, 3361, 3370, 3374], 'total': [2155, 2196, 2200, 2548, 3611], '(Cell': [2158], 'Signaling': [2159], 'Technology': [2160], 'Inc.);': [2161], '(Thr308)': [2163, 3354], 'anti-phospho-BAD': [2165, 3360], '(Ser136)': [2166], 'anti-BAD': [2169], 'monoclonal': [2170, 3366], 'antibody': [2171, 2214, 3367, 3441], '(Upstate': [2172], 'Biotechnology,': [2173, 2205, 3438], 'Inc.,': [2174], 'Lake': [2175], 'Placid,': [2176], 'NY);': [2177], 'anti-phospho-CREB': [2178, 3357], '(Ser133)': [2179, 3358], '(Calbiochem,': [2181], 'La': [2182], 'Jolla,': [2183], 'CA);': [2184], 'anti-ACTIVE': [2185, 2190, 3340, 3345], 'MAPK': [2186, 3341], '(ERK1/2)': [2187], '(Promega,': [2193], 'Madison,': [2194], 'WI);': [2195], 'ERK2': [2197], 'JNK1': [2201], '(Santa': [2203], 'Cruz': [2204], 'Santa': [2206], 'Cruz,': [2207], 'CA).': [2208], 'Horseradish': [2209], 'peroxidase-conjugated': [2210], 'goat': [2211, 3409, 3428], 'anti-rabbit': [2212, 3410], 'secondary': [2213], '(Sigma)': [2215], 'ECL': [2217], 'reagent': [2218, 3464], 'Hyperfilm-ECL': [2220], 'Amersham': [2224, 3281], 'Biosciences.': [2225], 'Elgastat': [2226], 'UHP': [2227], 'double': [2228], 'distilled': [2229], 'water': [2230], '(18.2': [2231], 'mΩ': [2232], 'grade)': [2233], 'throughout': [2236], 'study.': [2238], 'All': [2239, 2252, 3029, 3731], 'reagents': [2241, 2256], 'analytical': [2246], 'grade': [2247], 'Sigma.': [2251], 'Sigma': [2260], 'Merck.': [2262], 'Culture': [2264], 'Exposure—Primary': [2267], 'cultures': [2268, 2755, 2762, 4276], 'mouse': [2270], 'prepared': [2274], '(41Schroeter': [2278, 2660], '358:': [2289, 2671, 2744], '547-557Crossref': [2290, 2672, 2745], '(341)': [2293, 2675, 2748], '42Samanta': [2296, 4310], 'Perkinton': [2298, 4312], 'M.S.': [2299, 3111, 4313], 'Morgan': [2300, 4314], '70:': [2307, 4321], '2082-2090Crossref': [2308, 4322], '(75)': [2311, 4325], 'plated': [2317, 2354], 'onto': [2318], '6-': [2319, 4263], '24-well': [2321, 2486], 'Nunc': [2322, 2599], 'multiwell': [2323], 'plates': [2324, 3649], 'precoated': [2328], 'overnight': [2329, 3386], 'poly-l-ornithine': [2331], 'then': [2333, 3018, 3292, 3336, 3406], '10%': [2335, 3255], 'heat-inactivated': [2336], 'fetal': [2337], 'bovine': [2338], 'serum': [2339], '(Invitrogen)': [2340], '2': [2342, 2379, 2947, 3155, 4043], 'h.': [2343, 2501, 2525, 2618, 3568, 3593], 'Following': [2344, 2526, 2751, 2801, 3127, 3594, 4332], 'removal': [2345], 'final': [2348], 'coating': [2349], 'solution,': [2350], '(106/ml)': [2355, 3555], 'serum-free': [2358], 'medium': [2359, 2368, 2530, 2778, 3597], 'composed': [2360, 2407], 'mixture': [2363, 2402, 3162], "Dulbecco's": [2365], 'modified': [2366], "Eagle's": [2367], 'F-12': [2370], 'nutrient': [2371], '(1:1': [2372], 'v/v)': [2373], 'supplemented': [2374, 3326], '33': [2376], 'mm': [2377, 2380, 2383, 2387, 2780, 2783, 2786, 2789, 2793, 2796, 2799, 3146, 3152, 3156, 3166, 3174, 3179, 3247, 3299, 3304], 'glucose,': [2378, 2791], 'glutamine,': [2381], '6.5': [2382], 'sodium': [2384, 2424, 3167, 3175, 3180], 'bicarbonate,': [2385], '5': [2386, 2792, 3205, 3236], 'HEPES,': [2388, 2781], 'pH': [2389, 2630, 3249, 3301], '7.4,': [2390, 2631], '100': [2391, 2412], 'μg/ml': [2392, 2396, 2410, 2413, 2416, 3170], 'streptomycin,': [2393], '60': [2395, 2415, 3444], 'penicillin': [2397], '(all': [2398, 2426], 'Invitrogen).': [2400], 'A': [2401], 'hormones': [2404], 'salts': [2406], '25': [2409, 2979], 'insulin,': [2411], 'transferrin,': [2414], 'putrescine,': [2417], '20': [2418, 3331], 'nm': [2419, 2423, 2990, 3708], 'progesterone,': [2420], '30': [2422, 2957, 3314, 3585, 3857, 3901, 3981, 4338], 'selenate': [2425], 'Sigma)': [2428, 3525], 'added': [2431], 'culture': [2434], 'medium.': [2435, 3608], '37': [2441, 2805, 2960], '°C': [2442, 3209, 3240], 'humidified': [2445], 'atmosphere': [2446], '95%': [2448], 'air': [2449], '5%': [2451, 3253], 'CO2,': [2452], 'after': [2454, 2996, 3896, 3924, 4186, 4202], '5–7': [2455], 'days': [2456], 'vast': [2458], 'majority': [2459], '(>98%)': [2464], '<2%': [2466], 'astrocytes': [2467], 'determined': [2469, 3053, 3224], 'β-tubulin': [2471], 'glial': [2473], 'fibrillary': [2474], 'acidic': [2475], 'immunocytochemistry,': [2477], 'respectively': [2478], '(not': [2479], 'shown).': [2480], 'Primary': [2481], '(106': [2484, 2593], 'cells/ml;': [2485], 'plates)': [2487], 'exposed': [2489, 2604, 3461, 3479], '3′-O-methyl-': [2492, 2513], 'quercetin-7-O-β-d-glucuronide': [2496, 2517, 2610], '(0.3–10': [2497], '6': [2500, 2524, 2556, 2584, 2617, 3567, 3592, 3619, 3621, 3794, 3917, 3992, 4146, 4341], 'time': [2503, 3576, 4225], 'dependence': [2504], 'addition': [2510, 2771, 4272], '(3–30': [2518], '0.5,': [2521, 2581, 2614, 3589, 3989], '2,': [2522, 2582, 2615, 3590, 3990], 'all': [2527], 'exposures,': [2528, 2935, 3128, 3595], 'removed': [2532], 'replaced': [2534], 'fresh': [2536, 3606], 'conditioned': [2537, 3607], 'medium,': [2538], 'incubated': [2543, 2955, 3234, 3293, 3337, 3407, 3604, 3651], 'up': [2545, 2858], '24': [2550, 3817, 4016, 4171, 4257], 'h': [2551, 3614, 3795, 3818, 3918, 3923, 4017, 4044, 4147, 4172, 4201, 4258, 4342], '(exposure': [2552, 3615], 'reincubation': [2554, 3617, 4344], '18': [2558, 3922, 4200, 4346], 'h,': [2559, 3622, 3993, 4347], 'respectively)': [2560], 'before': [2561, 2640, 2769, 3657], 'assessment': [2562, 3063], 'viability.': [2565], 'addition,': [2567], 'assays': [2569], 'performed': [2575, 3105, 3725], 'immediately': [2576, 3929, 4024, 4213, 4269], 'following': [2577, 2620, 3819, 3852, 3911, 3930, 3986, 4003, 4025, 4075, 4214, 4270], 'exposures': [2579, 3836, 4007], '(i.e.': [2580], 'h).': [2585], 'analysis': [2587, 3070, 3103], 'proteins,': [2590], 'cells/ml)': [2594], 'grown': [2596], '6-well': [2598], 'plates.': [2600], '3′-O-methyl-quercetin,': [2607, 3560], '4′-O-methyl-quercetin,': [2608, 3561], '(0.3–30': [2611, 3564, 3791, 4143], 'Directly': [2619], 'exposure,': [2621], 'washed': [2625, 2764, 3132, 3398, 3450, 3627], 'twice': [2626, 2765, 3399, 3451, 3628], 'ice-cold': [2628, 3134, 3630], 'containing': [2632, 3158, 3307, 3378], 'EGTA/EDTA': [2633, 3157], '(200': [2634], 'lysed': [2637, 3141, 3183, 3637], 'ice': [2639, 3143, 3190, 3639, 3653], 'preparation': [2641], 'samples': [2643, 3232, 3263], 'immunoblotting.': [2645], 'Assessment': [2646], 'Neuronal': [2648], 'Damage—Cellular': [2649], 'elicited': [2651], 'treatments': [2653], 'evaluated': [2655], 'measuring': [2657], 'MTT': [2658, 2773, 2807, 2839, 3814, 4194], 'reduction': [2659, 4152], '43Spencer': [2678], 'Schroeter': [2680], 'Crossthwaithe': [2682], 'Med.': [2693], '31:': [2695], '1139-1146Crossref': [2696], '(141)': [2699], 'utilizing': [2703], 'Dead': [2705], 'Alive': [2707], 'assay': [2708], '(Molecular': [2709, 2852, 2972, 3719], 'Probes,': [2710], 'Eugene,': [2711], 'OR),': [2712], 'morphological': [2715, 3062, 4249], 'examination': [2716], '41Schroeter': [2733], 'exposure': [2752, 3587, 3821, 3823, 3897, 3912, 3926, 3974, 3987, 4142, 4187, 4218, 4260, 4333], 'sterile': [2767], 'PBS': [2768, 3135, 3631], '(0.5': [2774], 'mg/ml)': [2775], 'HEPES-buffered': [2777], '(5': [2779], '154': [2782], 'NaCl,': [2784, 3153], '4.6': [2785], 'KCl,': [2787], '2.3': [2788], 'CaCl2,33mm': [2790], 'NaHCO3,': [2794], '1.1': [2795], 'MgCl2,': [2797], '1.2': [2798], 'Na2HPO4).': [2800], 'incubation': [2802], '(60': [2803], 'min;': [2804], '°C),': [2806], 'solutions': [2808], 'removed,': [2810, 3599], 'formazan': [2813], 'product': [2814], 'solubilized': [2816], 'Me2SO,': [2818], 'absorbance': [2821, 3705, 3738], 'read': [2822], '505': [2824], 'nm.': [2825, 3000, 3701, 3742], 'results': [2827], 'percentages': [2832, 3046], 'reduction.': [2840], 'further': [2844, 4060], 'assessed': [2845, 3675], 'using': [2846, 2966, 3077, 3089, 3144, 3497, 3582, 3712, 3726, 3757, 4237], 'calcein': [2847, 2940, 2992, 4091], 'AM': [2848, 2855, 2941, 4092], 'ethidium': [2850, 2945, 4113], 'homodimer': [2851, 2894, 2946, 4114], 'Probes).': [2853], 'Calcein': [2854], 'living': [2860, 2898, 3048, 4100, 4118], 'cytoplasm': [2867], 'esterases': [2869], 'fluorescent': [2873, 4096], 'product,': [2874, 4097], 'calcein,': [2875, 4098], 'so': [2876], 'viable': [2878, 4157], 'show': [2880], 'uniform': [2882], 'fluorescence': [2884, 2920, 2963, 3041], '(emission,': [2885, 2921], '530': [2886, 2922, 2987], 'nm)': [2887, 2923], 'under': [2888, 2924, 3074], 'appropriate': [2889, 2925], 'excitation': [2890, 2926], '(495': [2891, 2927], 'nm).': [2892, 2928], 'Ethidium': [2893], 'excluded': [2896, 4116], 'but': [2900, 4267], 'can': [2901], 'cross': [2902, 4123], 'compromised': [2904, 4124], 'plasma': [2905, 4125], 'membrane': [2906, 3290, 4184, 4233], 'dying': [2908, 4128], 'nucleic': [2913, 4133], 'acids': [2914, 4134], 'give': [2916, 4136], 'red': [2919, 4139], 'At': [2929], 'end': [2931], 'experiment': [2934], 'washed,': [2939], '(4': [2942], 'added,': [2950], 'min': [2958, 3206, 3237, 3315, 3402, 3454, 3467, 3486, 3656], '°C.': [2961], 'measured': [2965, 3816, 4074], 'SPECTRAmax®': [2968], 'Gemini': [2969], 'microplate': [2970, 3717], 'spectrofluorometer': [2971], 'Devices).': [2973, 3720], 'temperature': [2975, 3318, 3389], 'maintained': [2977], '°C,': [2980], 'emission': [2983], 'recorded': [2985], '645': [2989], 'ethidium,': [2994], 'respectively,': [2995], 'exciting': [2997], '495': [2999], 'Each': [3001], 'scanned': [3004], 'scan': [3008], 'accumulating': [3010], '21': [3013], 'independent': [3014], 'points/well,': [3015], 'transformed': [3019], 'average': [3022], 'signal': [3023], 'relative': [3026], 'light': [3027, 3075, 4238], 'units.': [3028], 'calculated': [3032, 3512], 'normalized': [3034], 'respect': [3036], 'increase': [3039, 3800, 4163, 4176, 4211], 'dead': [3050, 4069, 4168, 4178], 'analyzed': [3055, 3496], 'statistically': [3056], "Student's": [3058, 3761], 't': [3059, 3762], 'test.': [3060], 'made': [3068, 3756], 'phenotypic': [3072], 'markers': [3073, 3519], 'microscopy': [3076, 4239], 'Nikon': [3079, 3091], 'eclipse': [3080], 'T5100': [3081], '40×': [3083], 'magnification.': [3084], 'images': [3086], 'captured': [3088], 'E995': [3092], 'digital': [3093], 'camera': [3094], 'fitted': [3095], 'Coolpix': [3098], 'MDC': [3099], 'lens': [3100], 'adaptor.': [3101], 'Immunoblotting—Immunoblotting': [3102], 'essentially': [3106], '(44Perkinton': [3110], 'Sihra': [3112], 'T.S.': [3113], '5861-5874Crossref': [3120], 'minor': [3125], 'modifications.': [3126], '200': [3137, 3634], 'μm': [3138, 3586, 3843, 3858, 3902], 'EGTA': [3139, 3633], '50': [3145, 3178], 'Tris,': [3147, 3248, 3300], '0.1%': [3148], 'Triton': [3149], 'X-100,': [3150], '150': [3151, 3303], '(1:100': [3163], 'dilution),': [3164, 3344, 3417, 3426], 'pyrophosphate,': [3168], '10': [3169, 3401, 3453, 3855, 3899], 'phenylmethylsulfonyl': [3171], 'fluoride,': [3172], 'vanadate,': [3176], 'fluoride.': [3181], 'scraped': [3186, 3646], 'left': [3188], 'solubilize': [3192], '45': [3194, 3655], 'min.': [3195, 3445], 'lysates': [3197, 3644, 3673], 'centrifuged': [3199], '1,000': [3201], '×': [3202, 3661], 'g': [3203], '4': [3208], 'remove': [3211], 'unbroken': [3212], 'debris': [3214], 'nuclei.': [3216], 'concentration': [3219], 'supernatants': [3222], 'Bio-Rad': [3227], 'Bradford': [3228], 'assay®.': [3230], '95': [3239], 'boiling': [3242], 'buffer': [3243, 3297, 3442], '(final': [3244], 'concentration,': [3245], '62.5': [3246], '6.8,': [3250], '2%': [3251], 'SDS,': [3252], '2-mercaptoethanol,': [3254], 'glycerol,': [3256], '0.0025%': [3258], 'bromphenol': [3259], 'blue).': [3260], 'boiled': [3262], '(20–30': [3264], 'μg/lane)': [3265], 'run': [3267, 3528], '9–12%': [3269], 'SDS-polyacrylamide': [3270], 'gels,': [3271], 'proteins': [3274, 3541], 'transferred': [3276], 'nitrocellulose': [3278, 3289, 3547], 'membranes': [3279, 4126], '(Hybond-ECL®;': [3280], 'Biosciences)': [3282, 3483], 'semi-dry': [3284], 'electroblotting': [3285], '(1.5': [3286], 'mA/cm2).': [3287], 'blocking': [3296], '(20': [3298], '7.5,': [3302], 'NaCl;': [3305], 'TBS)': [3306], '4%': [3308], '(w/v)': [3309, 3380], 'skimmed': [3310, 3381], 'milk': [3311, 3382], 'powder': [3312, 3383], 'room': [3317, 3388], 'followed': [3319], 'two': [3321, 3861], '5-min': [3322], 'washes': [3323], 'TBS': [3325, 3459], '0.05%': [3328], '(v/v)': [3329], 'Tween': [3330], '(TTBS).': [3332], 'blots': [3334, 3396, 3448, 3477], 'either': [3339], '(1:5000': [3343], '(1:5000),': [3348], '(1:1000),': [3352, 3356, 3359, 3362, 3368, 3371], 'anti-Bad,': [3363], 'clone': [3364], 'BYC001': [3365], 'anti-ERK1/ERK2': [3369], 'anti-JNK1': [3373], '(1:1000)': [3375], 'TTBS': [3377, 3404, 3456], '1%': [3379], '(antibody': [3384], 'buffer)': [3385], 'three-dimensional': [3392], 'rocking': [3393], 'table.': [3394], 'IgG': [3411, 3420, 3430], 'conjugated': [3412, 3421, 3431], 'horseradish': [3414, 3423, 3433], 'peroxidase': [3415, 3424, 3434], '(1:1000': [3416], 'rabbit': [3418], 'anti-sheep': [3419], '(1:2000': [3425], 'anti-mouse': [3429], '(1:3000': [3435], 'dilution;': [3436], 'Upstate': [3437], 'Inc.),': [3439], 'Finally': [3446], 'rinsed': [3457], 'ECL®': [3463], '1–2': [3466], "manufacturer's": [3472], 'protocol': [3473], '(Amersham': [3474, 3482], 'Biosciences).': [3475], 'Hyperfilm-ECL®': [3481], '2–5': [3485], 'autoradiographic': [3489], 'cassette': [3490], 'developed.': [3492], 'bands': [3494, 3510], 'BioImage®': [3498], 'Intelligent': [3499], 'Quantifier': [3500], 'software': [3501], '(Ann': [3502], 'Arbor,': [3503], 'MI).': [3504], 'molecular': [3506, 3517], 'weights': [3507], 'comparison': [3514, 4053], 'prestained': [3516], 'weight': [3518], '(molecular': [3520], 'weight,': [3521], '27,000–180,000': [3522], '6,500–45,000;': [3524], 'parallel': [3530], 'samples.': [3533], 'equal': [3535], 'loading': [3536], 'efficient': [3538], 'transfer': [3539], 'confirmed': [3543], 'staining': [3545], 'Ponceau': [3549], 'Red': [3550], '(Sigma).': [3551], 'Caspase-3': [3552], 'Activity—The': [3553], 'pretreated': [3557], 'quercetin-7-β-d-glucuronide': [3563], 'separate': [3571], 'series': [3572], 'experiments,': [3574], 'course': [3577], 'fixed': [3584], 'After': [3609], '12': [3613], 'respectively),': [3623], '(+': [3632], 'above.': [3642], 'centrifugation': [3658], '(microcentrifuge,': [3659], '1000': [3660], 'g),': [3662], 'supernatant': [3665], 'collected.': [3667], 'Caspase-3-like': [3668], 'based': [3676, 4084], 'hydrolysis': [3679], 'substrate': [3683], 'p-': [3685], 'nitroanilide': [3686], 'p-nitroaniline': [3695], 'moiety,': [3696], 'absorbs': [3698], '405': [3700, 3707, 3741], 'Quantification': [3702], 'carried': [3710], 'out': [3711], 'Versa': [3714], 'Max': [3715], 'UV': [3716], 'reader': [3718], 'Suitable': [3721], 'control': [3722], 'experiments': [3723], 'acetyl-Asp-Glu-Val-Asp-al.': [3730], 'presented': [3736], 'readings': [3739], 'Statistical': [3743, 3753], 'Analysis—The': [3744], 'means': [3750], '±': [3751, 3936, 3940, 3944, 3949, 3952], 'S.D.': [3752], 'comparisons': [3754], 'unpaired,': [3759], 'two-tailed': [3760], 'test': [3763], 'confidence': [3766], 'level': [3767, 3772], '95%.': [3769], 'significance': [3771, 3895], 'set': [3774], 'p': [3776], '<': [3777, 3845, 3904, 4046], '0.05.': [3778], 'Neurotoxicity': [3779], 'Its': [3783], 'Vivo': [3785], 'Metabolites—Exposure': [3786], 'resulted': [3796, 4148], 'concentration-dependent': [3799, 3875, 4151, 4162], 'evidenced': [3805], 'decreased': [3808], 'reduce': [3813], 'when': [3815], '(6-h': [3822], '18-h': [3825, 4265], 'reincubation)': [3826, 4266], '(Fig.': [3827, 3876, 4008, 4056, 4173, 4219, 4273, 4328, 4362], '1A).': [3828, 3877], 'Significant': [3829], 'low': [3838], '3': [3842], '(p': [3844, 3903, 4045], '0.01),': [3846, 4047], 'increased': [3850], 'substantially': [3851], 'impairment': [3869], 'function': [3872], 'much': [3885], 'seen': [3889], 'only': [3893, 3921, 3998, 4014, 4122, 4198], 'reached': [3894], '0.01).': [3905], 'Notably,': [3906], 'flavonols': [3915], '6-h': [3932, 4006, 4217], 'exposure:': [3933], '95.7%': [3935], '3.4%;': [3937], '3OmeQ,': [3938], '96.3%': [3939], '2.6%;': [3941], '4OmeQ,': [3942], '97.9%': [3943], '1.6%;': [3945], 'Q': [3946], 'glucuronide,': [3947], '98.3%': [3948], '1.2%;': [3950], 'mean': [3951], 'S.D.,': [3953], 'n': [3954], '=': [3955], '4).': [3956], 'Quercetin-7-O-β-d-glucuronide': [3957], 'toxicity': [3961, 3985, 4012], 'concentration.': [3964], 'neurotoxicity': [3966], 'apparent': [3971, 4015, 4023, 4212], 'shorter': [3973], 'times.': [3975], '(10': [3979, 4336], '(3': [3996], '2-': [4004], '1B).': [4009], 'Again': [4010], 'post-stress,': [4018], 'exposure.': [4027, 4076], '1C).': [4057], 'To': [4058], 'establish': [4059], 'properties': [4063], 'percentage': [4067, 4103, 4155, 4166], 'alive': [4071], 'percent': [4078], '"alive"': [4080], 'established': [4083], 'cytoplasmic': [4087], 'esterase': [4088], 'conversion': [4089], 'cells.': [4101], '"dead"': [4105], 'estimated': [4108], 'basis': [4111], 'will': [4121], 'fluorescence.': [4140], 'corresponding': [4161], '2A).': [4174], 'indicates': [4180], 'integrity': [4185], 'quercetin.': [4189], 'measurements,': [4195], 'completion': [4204], 'flavonoid': [4207], '2A),': [4220], 'indicating': [4221], 'alteration': [4230], 'integrity.': [4234], 'Morphological': [4235], 'analyses': [4236], 'highlighted': [4241], 'delayed': [4243], 'appearance': [4250], 'dramatically': [4255], 'affected': [4256], 'post-quercetin': [4259], 'μm;': [4262], '2B).': [4274], 'Control': [4275], 'exhibit': [4280], 'large': [4282], 'intact': [4283], 'body': [4285], 'finely': [4290], 'developed': [4291], 'dendritic': [4292], 'network': [4293], '2B,': [4329, 4363], 'panel': [4330], 'I).': [4331], 'bodies': [4351], 'appeared': [4352], 'shrunken,': [4353], 'dendrites': [4361], 'panels': [4364], 'III': [4365], 'IV).': [4367]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2001276434', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 11}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 23}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 21}], 'updated_date': '2024-12-13T03:11:15.618301', 'created_date': '2016-06-24'}