Abstract: The Breast JournalVolume 2, Issue 3 p. 209-220 Matrix Metalloproteinases in Breast Cancer Myriam Polette Ph. D., Myriam Polette Ph. D. I. N. S. E. R. M. U. 314 and Cell Biology Unit, C. H. U. de REIMS, Reims, FranceSearch for more papers by this authorPhilippe Birembaut M. D., Corresponding Author Philippe Birembaut M. D. I. N. S. E. R. M. U. 314 and Cell Biology Unit, C. H. U. de REIMS, Reims, FranceAddress correspondence and reprint requests to: Philippe Birembaut, I. N. S. E. R. M. U. 314, 45, rue Cognacq-Jay, 51 100 Reims, France.Search for more papers by this author Myriam Polette Ph. D., Myriam Polette Ph. D. I. N. S. E. R. M. U. 314 and Cell Biology Unit, C. H. U. de REIMS, Reims, FranceSearch for more papers by this authorPhilippe Birembaut M. D., Corresponding Author Philippe Birembaut M. D. I. N. S. E. R. M. U. 314 and Cell Biology Unit, C. H. U. de REIMS, Reims, FranceAddress correspondence and reprint requests to: Philippe Birembaut, I. N. S. E. R. M. U. 314, 45, rue Cognacq-Jay, 51 100 Reims, France.Search for more papers by this author First published: May 1996 https://doi.org/10.1111/j.1524-4741.1996.tb00097.xCitations: 12AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Abstract: Matrix metalloproteinases (MMPs) represent a class of enzymes able to degrade numerous extracellular matrix macromolecules facilitating tumor invasion and metastasis. The principal MMPs involved in breast pathology are analyzed with their various roles and functions: gelatinases A and B, stromelysin-3, collagenase-3, and MT-MMP1 (membrane type MMP). In vivo and in vitro studies clearly demonstrate an important cooperation between tumor and stromal cells for the expression of these MMPs in breast carcinomas. The large expression of MMPs plead in favor of a major role of these enzymes in breast carcinoma progression and their detection may be used in some cases as a prognostic indicator. Studies now are in progress, directed toward the modulation of these MMPs and their inhibitors with new therapeutic agents to block tumoral invasion and metastasis due to these enzymes.? Citing Literature Volume2, Issue3May 1996Pages 209-220 RelatedInformation