The α-Chemokine, Stromal Cell-derived Factor-1α, Binds to the Transmembrane G-protein-coupled CXCR-4 Receptor and Activates Multiple Signal Transduction Pathways

Name: Work Video:
Duration: 3 min 30 s
Ramesh K. Ganju; Stephanie A. Brubaker; Josua P. Meyer; Parmesh Dutt; Yang‐Ming Yang; Shixin Qin; Walter Newman; Jerome E. Groopman
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'https://openalex.org/W2020142500', 'https://openalex.org/W2008360372', 'https://openalex.org/W1970328728'], 'abstract_inverted_index': {'The': [0, 22, 174, 196, 573, 1914, 1986, 2110, 2146, 2164, 2206, 2241, 2260, 2519, 2569, 2607, 2619, 2705, 2772, 2812, 2836, 2864, 2904, 2928, 2957, 3027, 3052, 3120, 3141, 3337, 3379, 3589, 3601, 4330], 'α-chemokine': [1, 175], 'stromal': [2, 176, 351, 576], 'cell-derived': [3, 177, 352, 577], 'factor': [4, 178, 353, 578, 594, 796], '(SDF)-1α': [5, 179], 'binds': [6, 180], 'to': [7, 16, 41, 181, 190, 215, 786, 998, 1423, 1857, 1882, 1896, 2094, 2231, 2277, 2303, 2585, 2616, 3432, 3451, 3528, 3660, 3728, 3938, 4023, 4094], 'the': [8, 27, 69, 94, 151, 182, 201, 243, 268, 325, 510, 513, 519, 522, 1003, 1259, 1429, 1607, 1618, 1632, 1714, 1722, 1735, 1767, 1899, 1936, 1964, 1971, 1982, 1992, 2103, 2233, 2257, 2278, 2377, 2488, 2527, 2587, 2649, 2668, 2740, 2745, 2784, 2820, 2849, 2969, 2996, 3107, 3162, 3175, 3265, 3433, 3447, 3452, 3468, 3474, 3486, 3497, 3551, 3619, 3647, 3656, 3672, 3686, 3707, 3720, 3874, 3890, 4037, 4083, 4179, 4210, 4322, 4343, 4357, 4368, 4385, 4421, 4474, 4530], 'seven': [9, 183, 1126], 'transmembrane': [10, 184, 1127], 'G-protein-coupled': [11, 185, 1128], 'CXCR-4': [12, 42, 152, 186, 216, 326, 1006, 1123, 1197, 1260, 1419, 1616, 1710, 1753, 1897, 1967, 2101, 2147, 2165, 2191, 2242, 3613, 3634, 3641, 3673, 3679, 3708, 4029, 4327, 4360, 4525], 'receptor': [13, 187, 1005, 1129, 1203, 1261, 1615, 3648], 'and': [14, 20, 59, 76, 97, 112, 115, 171, 188, 194, 233, 250, 271, 286, 289, 345, 390, 405, 409, 532, 587, 739, 751, 800, 960, 1205, 1253, 1255, 1530, 1613, 1624, 1730, 1741, 1745, 1760, 1770, 1828, 1832, 1864, 1884, 1898, 1918, 1935, 2089, 2143, 2187, 2197, 2225, 2249, 2292, 2310, 2348, 2370, 2389, 2434, 2444, 2478, 2526, 2580, 2602, 2613, 2623, 2648, 2718, 2762, 2782, 2799, 2846, 2860, 2913, 2947, 2967, 2983, 2998, 3015, 3036, 3072, 3089, 3127, 3178, 3195, 3286, 3311, 3325, 3330, 3349, 3407, 3419, 3436, 3460, 3485, 3556, 3599, 3627, 3692, 3735, 3906, 3924, 3927, 3946, 4049, 4060, 4185, 4192, 4198, 4200, 4363, 4420, 4552], 'acts': [15, 189, 4415, 4557], 'modulate': [17, 191], 'cell': [18, 48, 168, 192, 222, 342, 362, 368, 592, 955, 1433, 1621, 1773, 1960, 2450, 2706, 2894, 3003, 3108, 3623, 3629, 3944, 4228], 'migration': [19, 96, 193, 270, 3945, 4338, 4358, 4370], 'proliferation.': [21, 195], 'signaling': [23, 163, 197, 337, 1633, 1758, 2352, 3684, 4096], 'pathways': [24, 164, 198, 338, 1634], 'that': [25, 141, 159, 165, 199, 315, 333, 339, 744, 1196, 1635, 1706, 1750, 1763, 2283, 3671, 4078, 4379, 4413, 4473, 4509, 4521], 'mediate': [26, 167, 200, 341, 1637, 1764], 'effects': [28, 202, 788, 1639], 'of': [29, 61, 63, 82, 89, 100, 203, 235, 237, 256, 263, 274, 399, 503, 512, 518, 1242, 1431, 1611, 1620, 1717, 1752, 1757, 1835, 2100, 2182, 2220, 2235, 2238, 2273, 2289, 2395, 2493, 2555, 2598, 2667, 2756, 2765, 2829, 2950, 3063, 3075, 3152, 3168, 3181, 3243, 3297, 3302, 3314, 3328, 3345, 3352, 3368, 3442, 3470, 3483, 3533, 3553, 3559, 3606, 3646, 3658, 3719, 3869, 3895, 3932, 4028, 4040, 4058, 4064, 4091, 4181, 4212, 4224, 4326, 4332, 4359, 4371, 4389, 4396, 4417, 4513, 4524, 4533, 4559], 'SDF-1α': [30, 39, 102, 142, 160, 204, 213, 276, 316, 334, 738, 779, 949, 994, 1529, 1612, 1707, 1732, 2396, 3700, 3859, 3879, 3898, 4026, 4051, 4173, 4206, 4213, 4319, 4355, 4522], 'are': [31, 205, 745, 3604, 3930], 'not': [32, 124, 206, 298, 1824, 3712], 'well': [33, 207, 1921, 3454], 'characterized.': [34, 208], 'We': [35, 78, 138, 209, 252, 312, 1954, 3855, 3865, 3884, 4169, 4208, 4506], 'studied': [36, 210], 'events': [37, 211], 'following': [38, 212, 3897], 'binding': [40, 214, 1430, 3260, 3499, 3657], 'in': [43, 147, 217, 321, 403, 784, 953, 1539, 1617, 1709, 1713, 1755, 1766, 1817, 2118, 2121, 2151, 2179, 2217, 2256, 2286, 2376, 2408, 2595, 2720, 2741, 2750, 2823, 2915, 2933, 3038, 3057, 3146, 3294, 3384, 3397, 3416, 3478, 3550, 3638, 3649, 3706, 3862, 3873, 3889, 3907, 3911, 3943, 4034, 4036, 4045, 4054, 4069, 4176, 4178, 4189, 4226, 4315, 4335, 4351, 4400, 4480, 4515, 4529], 'a': [44, 86, 218, 260, 590, 748, 793, 1000, 1125, 1426, 1842, 1956, 1975, 2809, 2992, 3098, 3204, 3365, 3463, 3595, 3715], 'model': [45, 219], 'murine': [46, 220, 1833, 1957, 3620, 3871], 'pre-B': [47, 221, 591, 790, 1251, 1958, 3621], 'line': [49, 223], 'transfected': [50, 224, 1990, 3617, 3628, 3651, 3875], 'with': [51, 225, 1826, 1974, 2124, 2174, 2211, 2246, 2264, 2308, 2364, 2392, 2502, 2531, 2552, 2576, 2583, 2625, 2709, 2715, 2898, 2910, 3012, 3033, 3112, 3124, 3250, 3270, 3513, 3538, 3690, 4088, 4183, 4196, 4365], 'human': [52, 226, 348, 802, 1831, 3678, 4481], 'CXCR-4.': [53, 227], 'There': [54, 228], 'was': [55, 229, 580, 995, 1808, 1841, 1931, 1939, 1947, 1979, 1988, 2092, 2105, 2529, 2661, 2748, 2774, 2806, 2815, 2838, 2867, 2930, 2959, 2989, 3054, 3095, 3201, 3261, 3339, 3382, 3615, 3915, 4203, 4339, 4547], 'enhanced': [56, 230, 2650, 4055, 4204], 'tyrosine': [57, 73, 98, 231, 247, 272, 359, 1726, 3892, 4056, 4387], 'phosphorylation': [58, 99, 232, 273, 1716, 3868, 4038, 4057, 4388], 'association': [60, 234, 4180, 4202], 'components': [62, 236, 3931, 4090], 'focal': [64, 72, 238, 246, 358, 1718, 1725, 3721, 3933, 4092], 'adhesion': [65, 71, 239, 245, 357, 1719, 1724, 3722, 3947], 'complexes': [66, 240, 2547, 2906, 3029, 3143, 3590], 'such': [67, 241], 'as': [68, 242, 589, 1425, 1786, 1920, 1922, 1995, 2322, 2484, 2677, 2808, 2869, 2991, 3097, 3203, 3212, 3409, 3491, 3564, 3900, 3917], 'related': [70, 244, 356, 1723], 'kinase,': [74, 128, 248, 302, 1744, 1861], 'paxillin,': [75, 249], 'Crk.': [77, 251, 4061], 'also': [79, 139, 253, 313, 961, 1771, 3885, 4382, 4471], 'observed': [80, 140, 254, 314, 3866, 3886, 4548], 'activation': [81, 255, 1751, 4080, 4512, 4532], 'phosphatidylinositol': [83, 90, 257, 264, 379], '3-kinase.': [84, 258], 'Wortmannin,': [85, 259], 'selective': [87, 261, 4344], 'inhibitor': [88, 262], '3-kinase,': [91, 265], 'partially': [92, 266, 4383], 'inhibited': [93, 267, 4367, 4384], 'SDF-1α-induced': [95, 269, 4337, 4369, 4386], 'paxillin.': [101, 275, 1731], 'treatment': [103, 143, 277, 317, 1733, 3701, 4027, 4174, 4320, 4381, 4523], 'selectively': [104, 278], 'activated': [105, 134, 279, 308, 1734, 3730], 'p44/42': [106, 280, 1736, 1862, 2997, 4534], 'mitogen-activated': [107, 119, 126, 281, 293, 300, 375, 385], 'protein': [108, 120, 127, 135, 282, 294, 301, 309, 376, 386, 950, 2469, 2494, 2503, 2556, 3066, 3158, 3244], 'kinase': [109, 118, 121, 122, 131, 136, 283, 292, 295, 296, 305, 310, 360, 378, 387, 1727, 2476, 2673, 2721, 2743, 2751, 2824, 2916, 2934, 3001, 3022, 3039, 3058, 3105, 3128, 3147, 3156, 3208, 3523, 3723, 3893, 3909, 4216, 4219, 4324, 4334, 4346, 4419, 4479, 4546], '(Erk': [110, 284, 1739], '1': [111, 285, 1740, 2133, 2287, 2304, 2426, 2514, 3014, 3323], 'Erk': [113, 287, 3013, 3016], '2)': [114, 288], 'its': [116, 290, 787, 1531, 1614, 1815], 'upstream': [117, 291, 4416, 4558], 'but': [123, 297], 'p38': [125, 299, 1859, 2999, 3020, 4544], 'c-Jun': [129, 303, 381], 'amino-terminal': [130, 304, 382, 1867], 'or': [132, 306, 524, 527, 530, 534, 2193, 2506, 2541, 2558, 2635, 3007, 3019, 3103, 3114, 3165, 3255, 4543], 'mitogen': [133, 307], 'kinase.': [137, 311, 388, 4536], 'increased': [144, 318, 1715, 4321], 'NF-κB': [145, 319, 3502], 'activity': [146, 320, 3894, 4325], 'nuclear': [148, 322, 3534], 'extracts': [149, 323], 'from': [150, 324, 583, 1845, 1874, 1888, 1903, 1912, 1928, 1933, 1940, 1949, 2495, 3005, 3245, 3608], 'transfectants.': [153, 327, 2097, 3864, 4329], 'Taken': [154, 328], 'together,': [155, 329], 'these': [156, 330, 1638, 2239, 3650, 4041, 4065, 4516], 'studies': [157, 331, 1748, 1812], 'revealed': [158, 332, 4378], 'activates': [161, 335, 3860], 'distinct': [162, 336], 'may': [166, 340, 1636], 'growth,': [169, 343], 'migration,': [170, 344, 1623, 3473], 'transcriptional': [172, 346], 'activation.': [173, 347], 'immunodeficiency': [349], 'virus': [350], 'phosphate-buffered': [354, 2175], 'saline': [355, 2176], 'fluorescence-activated': [361], 'sorter': [363], 'fetal': [364, 2126], 'calf': [365, 2127], 'serum': [366, 2128, 2805, 3426], 'total': [367], 'lysates': [369, 2451, 2707, 2895, 3004, 3109], 'room': [370, 2632], 'temperature': [371, 2633], 'polyacrylamide': [372, 3597], 'gel': [373, 3598], 'electrophoresis': [374], 'MAP': [377, 1737, 1860, 3000, 3021, 3155, 4418, 4535, 4545], '3-kinase': [380], 'kinase:': [383], 'MKK,': [384], 'Chemokines': [389, 3428], 'their': [391, 400, 3661], 'receptors': [392, 3664, 3680], 'have': [393, 505, 741, 962, 3935, 4470], 'recently': [394, 996, 3716], 'received': [395], 'considerable': [396], 'attention': [397], 'because': [398], 'emerging': [401], 'role': [402, 1610, 3942, 4331], 'immune': [404, 2746, 2821, 2905, 3028, 3142], 'inflammatory': [406], 'responses,': [407], 'hematopoiesis,': [408], 'HIV1': [410], 'infection': [411, 1538], '(1Rollins': [412, 536], 'B.J.': [413, 537], 'Blood.': [414, 437, 538, 1799, 2338, 2886, 4499], '1997;': [415, 479, 539, 700, 723, 910, 933, 1149, 1183, 1227, 1302, 1446, 1556, 1598, 1659, 1693, 2697, 2887, 3754], '90:': [416, 540, 2888], '909-928Crossref': [417, 541], 'PubMed': [418, 430, 441, 454, 482, 496, 542, 554, 568, 611, 634, 655, 682, 703, 731, 774, 821, 844, 865, 892, 913, 941, 989, 1028, 1049, 1084, 1101, 1157, 1186, 1235, 1283, 1305, 1324, 1396, 1416, 1449, 1472, 1507, 1524, 1564, 1601, 1667, 1696, 1803, 2021, 2051, 2084, 2342, 2700, 2890, 3235, 3757, 3795, 3822, 3850, 3959, 4000, 4015, 4108, 4149, 4164, 4251, 4269, 4292, 4308, 4446, 4463, 4503], 'Google': [419, 433, 442, 457, 468, 485, 499, 543, 557, 571, 614, 637, 658, 685, 706, 734, 777, 824, 847, 868, 895, 916, 944, 992, 1029, 1052, 1087, 1104, 1121, 1160, 1189, 1238, 1284, 1308, 1327, 1350, 1373, 1399, 1417, 1452, 1475, 1510, 1527, 1567, 1604, 1670, 1699, 1804, 2024, 2054, 2087, 2343, 2703, 2891, 3238, 3587, 3760, 3798, 3825, 3853, 3962, 4003, 4018, 4111, 4152, 4167, 4254, 4272, 4295, 4311, 4449, 4466, 4504], 'Scholar,': [420, 434, 443, 458, 469, 486, 544, 558, 615, 638, 659, 686, 707, 825, 848, 869, 896, 917, 1030, 1053, 1088, 1105, 1161, 1309, 1328, 1351, 1374, 1400, 1453, 1476, 1511, 1568, 1671, 2025, 2055, 3761, 3799, 3826, 3963, 4004, 4112, 4153, 4255, 4273, 4296, 4450], '2Premack': [421, 545], 'B.A.': [422, 546], 'Schall': [423, 547], 'T.J.': [424, 548], 'Nat.': [425, 549], 'Med.': [426, 492, 550, 564, 651, 699, 861, 909, 1182, 1320, 1597, 1692, 2017, 2696, 3753], '1996;': [427, 551, 652, 679, 862, 889, 986, 1046, 1081, 1098, 1118, 1469, 1504, 1521, 1800, 2018, 2043, 2081, 3227, 3956, 4105, 4243, 4305, 4460], '2:': [428, 552], '1174-1178Crossref': [429, 553], 'Scopus': [431, 455, 483, 497, 555, 569, 612, 635, 656, 683, 704, 732, 775, 822, 845, 866, 893, 914, 942, 990, 1050, 1085, 1102, 1158, 1187, 1236, 1306, 1325, 1397, 1450, 1473, 1508, 1525, 1565, 1602, 1668, 1697, 2022, 2052, 2085, 2701, 3236, 3758, 3796, 3823, 3851, 3960, 4001, 4016, 4109, 4150, 4165, 4252, 4270, 4293, 4309, 4447, 4464], '(572)': [432, 556], '3Bokoch': [435], 'G.M.': [436], '1995;': [438, 631, 771, 841, 3787, 3819, 3842, 3992, 4012, 4141, 4161, 4266, 4443], '86:': [439], '1649-1660Crossref': [440], '4Gerard': [444], 'C.': [445, 692, 902, 1038, 1061, 1113, 1340, 1461, 1484, 2012, 2065, 2077], 'Gerard': [446, 1112, 2007, 2011, 2058, 2076], 'N.P.': [447, 2008, 2059], 'Curr.': [448, 476, 1443, 3952, 4101, 4301], 'Opin.': [449, 477, 1444, 3953, 4102, 4302], 'Immunol.': [450, 464, 478, 1117, 1346, 1369, 1445], '1994;': [451, 465, 1022, 1277, 4289], '6:': [452], '140-145Crossref': [453], '(115)': [456], '5Taub': [459], 'D.D.': [460], 'Oppenheim': [461], 'J.J.': [462], 'Ther.': [463], '1:': [466], '229-246PubMed': [467], '6Moore': [470], 'J.P.': [471, 1438], 'Trkola': [472, 1439], 'A.': [473, 646, 688, 856, 898, 1057, 1301, 1317, 1334, 1338, 1440, 1480, 1586, 2069, 4279], 'Dragic': [474, 1441], 'T.': [475, 604, 606, 619, 627, 629, 661, 677, 694, 713, 759, 767, 769, 814, 816, 829, 837, 839, 871, 887, 904, 923, 968, 984, 1010, 1012, 1265, 1267, 1442, 1570, 1572, 1590, 1594, 3838], '9:': [480, 1447], '551-562Crossref': [481, 1448], '(455)': [484, 1451], '7Luster': [487, 559], 'A.D.': [488, 560], 'N.': [489, 561, 667, 673, 877, 883, 974, 980, 1408, 1578, 1582, 1592, 2029, 2067, 3967, 3982, 4116, 4131], 'Engl.': [490, 562], 'J.': [491, 563, 621, 649, 697, 719, 720, 761, 831, 859, 907, 929, 930, 1019, 1042, 1116, 1146, 1171, 1177, 1180, 1224, 1274, 1318, 1345, 1353, 1357, 1368, 1385, 1411, 1465, 1553, 1595, 1656, 1681, 1687, 1690, 1790, 2004, 2015, 2040, 2079, 2694, 3224, 3751, 3773, 3784, 3817, 3839, 3986, 3989, 4135, 4138, 4240, 4261, 4441, 4458], '1998;': [493, 565, 1321, 1347, 1370, 1388, 1413, 2339, 4500], '338:': [494, 566], '436-445Crossref': [495, 567], '(3272)': [498, 570], 'Scholar).': [500, 572, 735, 778, 945, 993, 1122, 1190, 1239, 1418, 1528, 1605, 1700, 1805, 2344, 2704, 2892, 3239, 3588, 3854, 4019, 4168, 4312, 4467, 4505], 'Four': [501], 'classes': [502], 'chemokines': [504, 3736], 'been': [506, 742, 1194, 1421, 3726, 3936, 4076, 4411], 'defined': [507], 'based': [508, 1813], 'on': [509, 789, 1814, 2102, 2611, 2796, 2858, 2980, 3086, 3192, 3359, 3462, 3472, 3594, 4214, 4541], 'arrangement': [511], 'conserved': [514], 'cysteine': [515], '(C)': [516], 'residues': [517], 'mature': [520], 'proteins;': [521], 'CXC': [523, 574], 'α-chemokines;': [525], 'CC': [526], 'β-chemokines;': [528], 'C': [529, 1780], 'γ-chemokines;': [531], 'CXXXC': [533], 'δ-chemokines': [535], 'chemokine,': [575], '(SDF-1α),': [579], 'first': [581], 'cloned': [582], 'mouse': [584, 3257], 'bone': [585, 957], 'marrow': [586, 958], 'characterized': [588], 'growth-stimulating': [593], '(8Tashiro': [595, 805], 'K.': [596, 623, 665, 763, 806, 833, 875, 972, 1380, 1576, 2879, 3830, 3836, 3969, 4118], 'Tada': [597, 624, 764, 807, 834], 'H.': [598, 625, 675, 765, 808, 835, 885, 982, 1036, 1143, 1221, 1459, 1542, 1580, 1653, 1792, 2063, 2333, 2685, 3742, 3783, 3803, 3828, 3834, 4427, 4494], 'Heilker': [599, 809], 'R.': [600, 810, 1014, 1141, 1145, 1219, 1223, 1269, 1330, 1367, 1651, 1655, 2061, 3576, 3765, 3805, 3965, 3978, 4114, 4127, 4429], 'Shirozu': [601, 811], 'M.': [602, 617, 757, 812, 827, 1008, 1016, 1034, 1075, 1077, 1107, 1263, 1271, 1344, 1355, 1359, 1457, 1498, 1500, 1584, 3832, 3975, 4124, 4257, 4259], 'Nakano': [603, 618, 758, 813, 828], 'Honjo': [605, 628, 768, 815, 838], 'Science.': [607, 817, 1097, 1520, 4459], '1993;': [608, 818, 3584], '261:': [609, 819], '600-603Crossref': [610, 820], '(638)': [613, 823], '9Shirozu': [616, 826], 'Inazawa': [620, 760, 830], 'Tashiro': [622, 762, 832], 'Shinohara': [626, 766, 836], 'Genomics.': [630, 770, 840], '28:': [632, 772, 842], '495-500Crossref': [633, 773, 843], '(537)': [636, 776, 846], '10Bleul': [639, 849], 'C.C.': [640, 850, 1032, 1092, 1286, 1455, 1515], 'Fuhlbrigge': [641, 851], 'R.C.': [642, 852], 'Casasnovas': [643, 853], 'J.M.': [644, 854, 1069, 1384, 1492, 1552, 3811, 4435], 'Aiuti': [645, 855], 'Springer': [647, 693, 857, 903, 1043, 1291, 1466], 'T.A.': [648, 858, 1044, 1292, 1467], 'Exp.': [650, 698, 860, 908, 1181, 1319, 1596, 1691, 2016, 2695, 3752], '184:': [653, 863], '1101-1109Crossref': [654, 864], '(1289)': [657, 867], '11Nagasawa': [660, 870], 'Hirota': [662, 872, 969], 'S.': [663, 669, 873, 879, 970, 976, 1137, 1215, 1300, 1404, 1647, 1796, 1798, 2000, 2039, 2335, 2691, 2883, 3578, 3748, 3763, 3769, 3775, 3801, 4425, 4456, 4496], 'Tachibana': [664, 874, 971, 1575], 'Takakura': [666, 876, 973], 'Nishikawa': [668, 878, 975], 'Kitamura': [670, 880, 977], 'Y.': [671, 881, 978, 1090, 1402, 1513, 1574, 3767], 'Yoshida': [672, 882, 979, 1581], 'Kikutani': [674, 884, 981], 'Kishimoto': [676, 886, 983, 1589], 'Nature.': [678, 888, 985, 1045, 1080, 1468, 1503, 2080, 3818, 4288, 4442], '382:': [680, 890, 987, 1047, 1082, 1470, 1505], '635-638Crossref': [681, 891, 988], '(2020)': [684, 894, 991], '12Aiuti': [687, 897], 'Webb': [689, 899], 'I.J.': [690, 900], 'Bleul': [691, 901], 'Gutierrez-Ramos': [695, 905], 'J.C.': [696, 906], '185:': [701, 911, 2698, 3755], '111-120Crossref': [702, 912], '(1206)': [705, 915], '13Sanchez': [708, 918], 'X.': [709, 919, 2031], 'Cousins-Hodges': [710, 920], 'B.': [711, 921, 1018, 1079, 1131, 1209, 1273, 1502, 1641, 2689, 2881, 3746, 3815, 3980, 4129, 4439], 'Aguilar': [712, 922], 'Gosselink': [714, 924], 'P.': [715, 925, 2327, 3807, 4431, 4488], 'Lu': [716, 926], 'Z.': [717, 927, 3221, 3580, 4237], 'Navarro': [718, 928], 'Biol.': [721, 931, 1020, 1147, 1225, 1275, 1386, 1554, 1657, 2041, 3225, 3785, 3840, 3955, 3990, 4011, 4104, 4139, 4160, 4241, 4304], 'Chem.': [722, 932, 1021, 1148, 1226, 1276, 1387, 1555, 1658, 2042, 3226, 3786, 3841, 3991, 4140, 4242], '272:': [724, 934, 1099, 1150, 1228, 1522, 1557, 1660], '27529-27531Abstract': [725, 935], 'Full': [726, 728, 936, 938, 1025, 1152, 1154, 1230, 1232, 1280, 1391, 1393, 1559, 1561, 1662, 1664, 2046, 2048, 3230, 3232, 3790, 3792, 3845, 3847, 3995, 3997, 4144, 4146, 4246, 4248], 'Text': [727, 729, 937, 939, 1026, 1153, 1155, 1231, 1233, 1281, 1392, 1394, 1560, 1562, 1663, 1665, 2047, 2049, 3231, 3233, 3791, 3793, 3846, 3848, 3996, 3998, 4145, 4147, 4247, 4249], 'PDF': [730, 940, 1027, 1156, 1234, 1282, 1395, 1563, 1666, 2050, 3234, 3794, 3849, 3999, 4148, 4250], '(38)': [733, 943], 'Two': [736], 'isoforms,': [737], 'SDF-1β,': [740], 'identified': [743, 3717], 'encoded': [746], 'by': [747, 753, 1202, 2107, 2228, 2269, 2315, 2455, 2468, 2500, 2523, 2550, 2605, 2776, 2801, 2818, 2840, 2847, 2862, 2961, 2985, 3091, 3197, 3263, 3277, 3288, 3341, 3374, 3655, 3697, 3731, 3902, 4081], 'single': [749], 'gene': [750], 'arise': [752], 'alternative': [754], 'splicing': [755], '(9Shirozu': [756], 'is': [780, 792, 1124, 1629, 4220], 'widely': [781], 'expressed': [782, 3643], 'and,': [783], 'addition': [785], 'cells,': [791, 1252], 'potent': [794], 'chemotactic': [795], 'for': [797, 1002, 1428, 1810, 1963, 2096, 2200, 2294, 2312, 2383, 2400, 2461, 2513, 2535, 2538, 2563, 2628, 2663, 2769, 2786, 2833, 2851, 2952, 2971, 3077, 3161, 3174, 3183, 3334, 3501, 3545, 3633], 'monocytes,': [798, 1249], 'T-lymphocytes,': [799], 'CD34+': [801], 'progenitor': [803], 'cells': [804, 1244, 1257, 1994, 2112, 2207, 2261, 2282, 2405, 3009, 3413, 3443, 3475, 3675, 3687, 3710, 3877, 4031, 4372, 4527], 'Knock-out': [946], 'mice': [947], 'lacking': [948], 'show': [951, 1705], 'abnormalities': [952], 'B': [954, 3923, 4551], 'lymphopoiesis,': [956], 'myelopoiesis,': [959], 'nonfatal': [963], 'ventricular': [964], 'septal': [965], 'defects': [966], '(11Nagasawa': [967], 'shown': [997, 1195, 1422, 3603, 3637, 3727, 3937, 4044, 4077, 4188, 4314, 4350, 4412, 4472], 'be': [999, 1200, 3729], 'ligand': [1001], 'chemokine': [1004, 3663], '(14Loetscher': [1007, 1262], 'Geiser': [1009, 1264], "O'Reilly": [1011, 1266], 'Zwahlen': [1013, 1268], 'Baggiolini': [1015, 1076, 1270, 1499], 'Moser': [1017, 1078, 1272, 1501], '269:': [1023, 1278], '232-237Abstract': [1024, 1279], '15Bleul': [1031, 1454], 'Farzan': [1033, 1456], 'Choe': [1035, 1458, 2062], 'Parolin': [1037, 1460, 2064], 'Clark-Lewis': [1039, 1070, 1462, 1493], 'I.': [1040, 1071, 1135, 1165, 1213, 1463, 1494, 1645, 1675, 4454], 'Sodroski': [1041, 1464], '829-833Crossref': [1048, 1471], '(1755)': [1051, 1474], '16Oberlin': [1054, 1477], 'E.': [1055, 1332, 1382, 1478, 2073, 3809, 3973, 4122, 4433], 'Amara': [1056, 1479], 'Bachelerie': [1058, 1481], 'F.': [1059, 1065, 1311, 1482, 1488], 'Bessia': [1060, 1483], 'Virelizier': [1062, 1485], 'J.L.': [1063, 1486, 3971, 4120], 'Arenzana-Seisdedos': [1064, 1487], 'Schwartz': [1066, 1489], 'O.': [1067, 1490, 1588], 'Heard': [1068, 1491], 'Legler': [1072, 1495], 'D.F.': [1073, 1496], 'Loetscher': [1074, 1497], '833-835Crossref': [1083, 1506], '(1484)': [1086, 1509], '17Feng': [1089, 1512], 'Broder': [1091, 1514], 'Kennedy': [1093, 1516], 'P.E.': [1094, 1517], 'Berger': [1095, 1518], 'E.A.': [1096, 1519], '872-877Crossref': [1100, 1523], '(3643)': [1103, 1526], '18Heesen': [1106], 'Berman': [1108], 'M.A.': [1109, 1173, 1544, 1683, 2687, 3744], 'Benson': [1110], 'J.D.': [1111, 1406], 'Dorf': [1114], 'M.E.': [1115], '157:': [1119], '5455-5460PubMed': [1120], '(19Haribabu': [1130, 1208, 1640], 'Richardson': [1132, 1210, 1642], 'R.M.': [1133, 1211, 1643], 'Fisher': [1134, 1212, 1644], 'Sozzani': [1136, 1214, 1646], 'Peiper': [1138, 1216, 1648], 'S.C.': [1139, 1217, 1649], 'Horuk': [1140, 1218, 1366, 1650], 'Ali': [1142, 1220, 1652], 'Snyderman': [1144, 1222, 1654], '28726-28731Abstract': [1151, 1229, 1661], '(245)': [1159, 1237, 1669], '20Davis': [1162, 1672], 'C.B.': [1163, 1673], 'Dikic': [1164, 1674, 4453], 'Unutmaz': [1166, 1676], 'D.': [1167, 1313, 1336, 1365, 1677, 2035, 3771, 3988, 4137], 'Hill': [1168, 1678], 'C.M.': [1169, 1679], 'Arthos': [1170, 1680], 'Siani': [1172, 1543, 1682], 'Thompson': [1174, 1547, 1684], 'D.A.': [1175, 1548, 1685], 'Schlessinger': [1176, 1686, 3816, 4440, 4457], 'Littman': [1178, 1688], 'D.R.': [1179, 1689], '186:': [1184, 1599, 1694], '1793-1798Crossref': [1185, 1695], '(344)': [1188, 1698], 'Recently,': [1191, 4468], 'it': [1192], 'has': [1193, 1420, 3725, 4075, 4409], 'expression': [1198, 1984, 2099, 2237], 'can': [1199, 1534], 'regulated': [1201], 'phosphorylation-dependent': [1204], '-independent': [1206], 'mechanisms': [1207], 'A': [1240, 4048], 'diversity': [1241], 'white': [1243], 'including': [1245, 1721], 'peripheral': [1246], 'blood': [1247], 'lymphocytes,': [1248], 'thymocytes,': [1250], 'dendritic': [1254], 'endothelial': [1256], 'express': [1258], 'Scholar,21Bleul': [1285], 'Wul': [1287], 'L.': [1288, 2006, 2027, 2057, 2329, 4490], 'Hoxie': [1289, 1356], 'J.A.': [1290, 4277], 'Mackay': [1293, 1314, 2013, 2036], 'C.R.': [1294, 1315, 2014, 2037], 'Proc.': [1295], 'Natl.': [1296], 'Acad.': [1297], 'Sci.': [1298], 'U.': [1299], '94:': [1303], '1925-1930Crossref': [1304], '(952)': [1307], '22Sallusto': [1310], 'Lenig': [1312], 'Lanzavecchia': [1316], '187:': [1322], '875-883Crossref': [1323], '(1378)': [1326], '23Forster': [1329], 'Kremmer': [1331], 'Schubel': [1333], 'Breitfeld': [1335], 'Kleinschmidt': [1337], 'Nerl': [1339], 'Bernhardt': [1341], 'G.': [1342, 4452], 'Lipp': [1343], '160:': [1348, 1371], '1522-1531PubMed': [1349], '24Hesselgesser': [1352], 'Liang': [1354], 'Greenberg': [1358], 'Brass': [1360], 'L.F.': [1361], 'Orsini': [1362], 'M.J.': [1363], 'Taub': [1364], '877-883PubMed': [1372], '25Gupta': [1375], 'S.K.': [1376], 'Lysko': [1377], 'P.G.': [1378], 'Pillarisetti': [1379], 'Ohlstein': [1381], 'Stadel': [1383], '273:': [1389, 4461], '4282-4287Abstract': [1390], '(368)': [1398], '26Yi': [1401], 'Rana': [1403], 'Turner': [1405], 'Gaddis': [1407], 'Collman': [1409], 'R.G.': [1410], 'Virol.': [1412], '72:': [1414], '772-777Crossref': [1415], 'act': [1424], 'co-receptor': [1427], 'T': [1432], 'tropic': [1434], 'HIV-1': [1435, 1537], 'strains': [1436], '(6Moore': [1437], 'various': [1532, 2401, 3732], 'analogues': [1533], 'inhibit': [1535], 'CXCR-4-mediated': [1536], 'vitro': [1540, 2672, 2742, 3908], '(27Ueda': [1541], 'Gong': [1545], 'W.': [1546, 2010, 2033, 2075, 2331, 4492], 'Brown': [1549], 'G.G.': [1550], 'Wang': [1551, 2003, 2876], '24966-24970Abstract': [1558], '(61)': [1566], '28Murakami': [1569], 'Nakajima': [1571], 'Koyanagi': [1573], 'Fujii': [1577], 'Tamamura': [1579], 'Waki': [1583], 'Matsumoto': [1585], 'Yoshie': [1587], 'Yamamoto': [1591], 'Nagasawa': [1593], '1389-1393Crossref': [1600], '(365)': [1603, 3852], 'Despite': [1606], 'increasingly': [1608], 'prominent': [1609], 'regulation': [1619], 'proliferation,': [1622], 'HIV': [1625], 'infection,': [1626], 'relatively': [1627], 'little': [1628], 'known': [1630], 'about': [1631], 'In': [1701, 2671], 'this': [1702, 2152, 3682, 4201], 'study,': [1703], 'we': [1704, 4021, 4469], 'stimulation': [1708, 3880, 4052], 'transfectants': [1711, 2104, 2148, 2167, 2243, 3642, 4484], 'results': [1712, 1754, 3602, 4175], 'components,': [1720], '(RAFTK/Pyk2),': [1728], 'Crk,': [1729, 3928], 'kinases': [1738], '2),': [1742], 'PI-3': [1743, 3207, 4215, 4218, 4323, 4333, 4345], 'NF-κB.': [1746], 'These': [1747], 'indicate': [1749], 'modulation': [1756], 'molecules': [1759], 'transcription': [1761], 'factors': [1762, 3734], 'changes': [1765, 4035, 4177], 'cytoskeletal': [1768], 'apparatus': [1769], 'regulate': [1772], 'growth.': [1774], 'RAFTK': [1775, 2710, 3861, 3872, 3896, 4414, 4510], 'antibodies': [1776, 1856, 1895, 2534, 3116], 'were': [1777, 1872, 1886, 1902, 1910, 1926, 2113, 2149, 2171, 2208, 2244, 2262, 2284, 2301, 2354, 2361, 2381, 2406, 2453, 2466, 2481, 2498, 2521, 2548, 2572, 2593, 2609, 2621, 2641, 2675, 2712, 2793, 2855, 2896, 2907, 2978, 3010, 3030, 3084, 3110, 3122, 3144, 3190, 3210, 3248, 3292, 3357, 3404, 3429, 3444, 3455, 3476, 3489, 3511, 3536, 3591, 3631, 3688, 3695, 4067, 4398], 'generated': [1778], 'using': [1779, 2643, 3364, 3521, 4342], 'domain': [1781], 'glutathione': [1782], 'S-transferase': [1783], 'fusion': [1784, 3157, 3170], 'proteins': [1785, 1868, 2592, 4066], 'described': [1787, 1996, 2323, 2485, 2678, 2870, 3213, 3492, 3565], 'previously': [1788, 3566, 4410], '(29Li': [1789], 'Avraham': [1791, 1797, 2332, 2334, 2684, 2690, 2882, 3741, 3747, 3782, 4493, 4495], 'Rogers': [1793], 'R.A.': [1794, 3779], 'Raja': [1795], '88:': [1801], '417-428Crossref': [1802], 'Serum': [1806], 'R-4250': [1807], 'chosen': [1809], 'further': [1811, 2603, 4340, 4507], 'titer': [1816], 'enzyme-linked': [1818], 'immunosorbent': [1819], 'assay.': [1820], 'This': [1821], 'antiserum': [1822, 2711], 'does': [1823], 'cross-react': [1825], 'FAK': [1827], 'recognizes': [1829], 'both': [1830], 'forms': [1834], 'RAFTK.': [1836, 4186], 'Monoclonal': [1837, 1894, 2657], 'anti-phosphotyrosine': [1838, 3252], 'antibody': [1839, 2192, 2627, 2647, 2658, 2900, 3023, 3253], '(4G10)': [1840, 3254], 'generous': [1843], 'gift': [1844], 'Dr.': [1846], 'Brian': [1847], 'Druker': [1848, 2688, 3745, 3979, 4128], '(Oregon': [1849], 'Health': [1850], 'Sciences': [1851], 'University,': [1852], 'Portland,': [1853], 'OR).': [1854, 1953], 'Purified': [1855], 'JNK,': [1858], 'MAPK,': [1863], 'recombinant': [1865, 2937, 3153], 'GST-c-Jun': [1866, 2938], '(1–79': [1869, 2941], 'amino': [1870, 1972, 2942], 'acids)': [1871, 2943], 'obtained': [1873, 1887, 1911, 1927, 1932], 'Santa': [1875], 'Cruz': [1876, 2902, 2945, 3025, 3118], 'Laboratories': [1877], '(Santa': [1878, 2901, 2944, 3024, 3117, 3159, 3172], 'Cruz,': [1879], 'CA).': [1880, 1907], 'Antibodies': [1881], 'paxillin': [1883, 4059, 4184, 4197, 4390, 4397], 'Crk': [1885, 4086, 4182, 4194], 'Transduction': [1889], 'Laboratories,': [1890], 'Inc.': [1891], '(Lexington,': [1892], 'KY).': [1893], 'isotype': [1900, 2194], 'control': [1901, 2195], 'PharMingen': [1904], '(San': [1905], 'Diego,': [1906], 'Electrophoresis': [1908], 'reagents': [1909, 1925], 'Bio-Rad.': [1913, 1941], 'protease': [1915], 'inhibitors': [1916], 'leupeptin': [1917], 'α1-antitrypsin': [1919], 'all': [1923, 2349], 'other': [1924, 2350, 4089], 'Sigma.': [1929], 'Wortmannin': [1930], 'Calbiochem,': [1934], 'nitrocellulose': [1937, 2617], 'membrane': [1938], 'Indo-1': [1942, 2265, 2275], 'acetoxymethyl': [1943], 'ester': [1944], '(Indo-1': [1945], 'AM)': [1946], 'purchased': [1948], 'Molecular': [1950], 'Probes': [1951], '(Eugene,': [1952], 'used': [1955, 2093, 2662, 2807, 2990, 3096, 3202, 3916], 'lymphoma': [1959, 3622], 'line,': [1961, 3624], 'L1.2,': [1962], 'transfection': [1965], 'studies.': [1966], 'cDNA,': [1968], 'tagged': [1969], 'at': [1970, 2115, 2203, 2251, 2297, 2356, 2372, 2386, 2397, 2457, 2516, 2543, 2566, 2631, 2767, 2789, 2831, 2955, 2974, 3080, 3186, 3332, 3376, 3548], 'terminus': [1973], 'Flag': [1976], 'epitope': [1977], '(Asp-Tyr-Lys-Asp-Asp-Asp-Asp-Lys),': [1978], 'subcloned': [1980], 'into': [1981, 1991, 3618], 'pcDNAIII': [1983], 'vector.': [1985], 'DNA': [1987, 3540], 'stably': [1989, 3616], 'L1.2': [1993, 2111, 2166, 3674, 3709, 3863, 3876, 4030, 4328, 4361, 4483, 4526], '(30Ponath': [1997], 'P.D.': [1998], 'Qin': [1999, 2038], 'Post': [2001], 'T.W.': [2002], 'Wu': [2005, 2328, 4489], 'Newman': [2009, 2032, 2074, 2330, 4491], '183:': [2019], '2437-2448Crossref': [2020], '(553)': [2023], '31Wu': [2026], 'Ruffing': [2028, 2066], 'Shi': [2030], 'Soler': [2034], '271:': [2044, 3228, 4244], '31202-31209Abstract': [2045], '(88)': [2053], '32Wu': [2056], 'Wyatt': [2060], 'Borsetti': [2068], 'Cardoso': [2070], 'A.A.': [2071], 'Desjardin': [2072], 'Sodorski': [2078], '384:': [2082], '179-181Crossref': [2083], '(1083)': [2086], 'Scholar),': [2088], 'G418-selective': [2090], 'medium': [2091, 3400, 3421, 3479], 'select': [2095], 'Cell-surface': [2098], 'confirmed': [2106], 'FACS': [2108, 3698], 'analysis.': [2109, 3699], 'grown': [2114, 2150, 3396], '37': [2116, 2298, 2387, 2398], '°C': [2117, 2388, 2399, 2637], '5%': [2119, 2185, 2214, 2222], 'CO2': [2120], 'RPMI': [2122, 2153, 2247, 2258, 2290, 2365, 3398, 3417], '1640': [2123, 2154, 2248, 2366, 3399, 3418], '10%': [2125, 2797, 3402], '(FCS),': [2129], '2': [2130, 3017, 3346, 3882], 'mm': [2131, 2134, 2413, 2424, 2427, 2437, 2441, 2446, 2724, 2729, 2732, 2735, 2919, 3042, 3047, 3131, 3136, 3279, 3283, 3318, 3347], 'glutamine,': [2132], 'sodium': [2135, 2421, 2438, 2442, 2447], 'pyruvate,': [2136], '50': [2137, 2140, 2553, 2728], 'μg/ml': [2138, 2141, 2189, 2431], 'penicillin,': [2139], 'streptomycin,': [2142], '55': [2144], 'μmβ-mercaptoethanol.': [2145], 'media': [2155], 'containing': [2156, 2184, 2753, 2826, 2936, 3060, 3149, 3272, 3281, 3387, 3401, 3423, 3480, 3496], '0.8': [2157], 'mg/ml': [2158], 'Geneticin': [2159], '(G418)': [2160], '(Life': [2161, 2367], 'Technologies,': [2162, 2368], 'Inc.).': [2163], '(1': [2168, 3317, 3439], '×': [2169, 2253, 2280, 2305, 2374, 2459, 3411, 3440], '106)': [2170, 3441], 'washed': [2172, 2209, 2245, 2362, 2573, 2713, 2908, 3031, 3123, 3405], 'twice': [2173, 2210, 2363, 2714, 2909, 3032, 3406], '(PBS),': [2177], 'resuspended': [2178, 2216, 2250, 2371, 3293, 3477], '100': [2180, 2737, 2790, 2975, 3437], 'μl': [2181, 2219, 2272, 2554, 2597, 3296, 3301, 3313, 3344, 3351, 3438], 'PBS': [2183, 2584, 3271], 'FCS': [2186, 2223, 3403], '5': [2188, 2271, 2731, 2734, 2763, 2787, 2827, 2852, 2948, 2972, 3073, 3179, 3326, 4317, 4353, 4374, 4392, 4404], 'PE-labeled': [2190], '(PharMingen),': [2196], 'then': [2198, 2226, 2390, 2614, 2794, 2856, 2931, 3055, 3287, 3430, 3592], 'incubated': [2199, 2293, 2530, 2749, 2932, 3056, 3145, 3331, 3537], '30': [2201, 2770, 2834, 3081, 3187], 'min': [2202, 2296, 2788, 2954, 2973, 3079, 3185, 3547], '4': [2204, 2384, 2517, 2539, 2544, 2564, 2567, 2636], '°C.': [2205, 2299, 2518, 2545, 2568, 2791, 2976, 3082, 3188, 3378], 'ice-cold': [2212], 'PBS,': [2213, 2221], 'FCS,': [2215], '500': [2218], 'buffer,': [2224, 3299], 'analyzed': [2227, 2311, 2604, 3632], 'flow': [2229, 2316, 3464], 'cytometry': [2230, 2317], 'determine': [2232], 'levels': [2234, 3645], 'surface': [2236], 'receptors.': [2240], '10': [2252, 2279, 2373, 2430, 2436, 2440, 2445, 2462, 2923, 2953, 3046, 3135, 3312, 3320, 3335, 3410, 3531, 3546], '106': [2254, 2281, 3412], 'cells/ml': [2255], 'medium.': [2259, 2379], 'loaded': [2263, 3445], 'AM': [2266], '(Molecular': [2267], 'Probes)': [2268], 'adding': [2270, 2777, 2841, 2962, 3342], 'working': [2274], 'solution': [2276, 2291, 2528], 'suspended': [2285, 3408], 'ml': [2288, 3415], '45': [2295], 'Cells': [2300, 2360, 2380, 3395, 3449], 'diluted': [2302], '106/ml,': [2306], 'treated': [2307, 3689], 'SDF-1α,': [2309, 3691], 'calcium': [2313, 3667, 3693, 3704], 'mobilization': [2314], '(Coulter': [2318], 'Electronics,': [2319], 'Hialeah,': [2320], 'FL)': [2321], '(33Ganju': [2324, 4485], 'R.K.': [2325, 2681, 2875, 3738, 4486], 'Dutt': [2326, 4487], 'Groopman': [2336, 2692, 2884, 3749, 3780, 4497], 'J.E.': [2337, 2693, 2885, 3750, 3781, 4498], '91:': [2340, 4501], '791-797Crossref': [2341, 4502], 'Calcium': [2345], 'flux': [2346], 'assays': [2347, 2353, 2480, 2674, 3209, 3488], 'subsequent': [2351], 'repeated': [2355], 'least': [2357], 'three': [2358, 2574, 3267, 3609], 'times.': [2359], 'Inc.)': [2369], '106cells/ml': [2375], 'same': [2378], 'starved': [2382], 'h': [2385, 2515, 2540, 2565, 2630, 3459], 'stimulated': [2391, 3008, 4477], 'different': [2393, 2532, 3481], 'concentrations': [2394, 2465, 3482], 'periods.': [2402], 'After': [2403], 'stimulation,': [2404], 'lysed': [2407], 'modified': [2409, 2577], 'RIPA': [2410, 2578, 2716, 2911, 3034, 3125], 'buffer': [2411, 2579, 2601, 2717, 2722, 2752, 2781, 2825, 2845, 2912, 2917, 2935, 2966, 3035, 3040, 3059, 3126, 3129, 3148, 3555], '(50': [2412, 2918, 3041, 3130], 'Tris-HCl,': [2414], 'pH': [2415, 2726, 2921, 3044, 3133], '7.4,': [2416, 2727, 2922, 3045, 3134], '1%': [2417, 3273], 'Nonidet': [2418, 3274], 'P-40,': [2419, 3275], '0.25%': [2420], 'deoxycholate,': [2422], '150': [2423], 'NaCl,': [2425, 2730], 'phenylmethylsulfonyl': [2428], 'fluoride,': [2429, 2443], 'aprotinin,': [2432], 'leupeptin,': [2433], 'pepstatin,': [2435], 'vanadate,': [2439], 'pyrophosphate).': [2448], 'Total': [2449], '(TCL)': [2452], 'clarified': [2454, 2499], 'centrifugation': [2456], '10,000': [2458], 'g': [2460], 'min.': [2463, 2771, 2835, 2853, 3336], 'Protein': [2464], 'determined': [2467, 3901], 'assay': [2470, 2814, 2866, 3164, 3381, 3905, 3910], '(Bio-Rad).': [2471], 'Cell': [2472, 3581, 3954, 4103, 4303], 'lysis,': [2473], 'immunoprecipitation,': [2474], 'immunoblotting,': [2475], 'assays,': [2477, 2744, 3002, 3106], 'autophosphorylation': [2479, 2813, 3904], 'carried': [2482, 2816], 'out': [2483, 2817], 'below.': [2486], 'For': [2487, 2739, 2995, 3101], 'immunoprecipitation': [2489], 'studies,': [2490], 'identical': [2491], 'amounts': [2492, 3242, 4063, 4395], 'each': [2496, 2536, 3246, 3269, 4070, 4401], 'sample': [2497, 2780, 2785, 2844, 2850, 2965, 2970, 3247], 'incubation': [2501, 2551], 'A-Sepharose': [2504, 2557], 'CL-4B': [2505], 'Gammabind': [2507, 2559], 'plus': [2508], 'Sepharose': [2509, 2560, 2570], '(Amersham': [2510, 2654], 'Pharmacia': [2511, 2655], 'Biotech)': [2512], 'beads': [2520, 2571], 'removed': [2522, 3262], 'brief': [2524], 'centrifugation,': [2525], 'primary': [2533, 2626], 'experiment': [2537], 'overnight': [2542], 'Antibody-antigen': [2546], 'immunoprecipitated': [2549, 2708, 2897, 3011, 3111, 3249], '(10%': [2561], 'suspension)': [2562], 'times': [2575, 3268], 'one': [2581], 'time': [2582], 'remove': [2586], 'nonspecifically': [2588], 'bound': [2589], 'proteins.': [2590, 4042], 'Bound': [2591], 'solubilized': [2594], '40': [2596], '2×': [2599, 2778, 2963], 'Laemmli': [2600], 'immunoblotting.': [2606], 'samples': [2608, 3266], 'separated': [2610, 2795, 2857, 2979, 3085, 3191, 3358, 3593], 'SDS-PAGE': [2612, 2798, 2859, 2982, 3088, 3194], 'transferred': [2615], 'membranes.': [2618], 'membranes': [2620], 'blocked': [2622], 'probed': [2624], '3': [2629], '(RT)': [2634], 'overnight.': [2638], 'Immunoreactive': [2639], 'bands': [2640], 'visualized': [2642], 'horseradish': [2644], 'peroxidase-conjugated': [2645], 'secondary': [2646], 'chemiluminescent': [2651], '(ECL)': [2652], 'system': [2653, 3367], 'Biotech).': [2656], '(4G10,': [2659], 'IgG2a)': [2660], 'Western': [2664], 'blot': [2665], 'analysis': [2666], 'phosphotyrosine': [2669], 'protein.': [2670], 'performed': [2676, 2868, 3211, 3383], 'earlier': [2679, 2871], '(34Ganju': [2680, 3737], 'Hatch': [2682, 3739], 'W.C.': [2683, 3740], 'Ona': [2686, 3743], '1055-1063Crossref': [2699, 3756], '(94)': [2702, 3759], 'once': [2719, 2914, 3037], '(20': [2723], 'HEPES,': [2725, 2920, 3043, 3132, 3319], 'MgCl2,': [2733, 3137], 'MnCl2,': [2736], 'mmNa3VO4).': [2738], 'complex': [2747, 2822, 2929, 3053], '25': [2754], 'μg': [2755, 3062, 3151, 3167, 3532], 'poly(Glu:Tyr)': [2757, 3913], '(4:1),': [2758], '20–50': [2759], 'kDa': [2760], '(Sigma),': [2761], 'μCi': [2764, 2828, 2949, 3074, 3180, 3327], '[γ-32P]ATP': [2766, 2830, 2951, 3076, 3182, 3514], 'RT': [2768, 2832, 3333, 3549], 'reaction': [2773, 2837, 2958, 3338], 'stopped': [2775, 2839, 3340], 'SDS': [2779, 2843, 2964], 'boiling': [2783, 2848, 2968], 'Proteins': [2792, 2854, 2977, 3083, 3189], 'detected': [2800, 2861, 2984, 3090, 3196], 'autoradiography.': [2802, 2863, 2986, 3092, 3198], 'Normal': [2803], 'rabbit': [2804], 'negative': [2810, 2993, 3099, 3205], 'control.': [2811, 2994, 3100, 3206], 'incubating': [2819], '4×': [2842], 'JNK': [2865, 2899, 3169, 4422, 4478, 4514, 4542], '(35Liu': [2872], 'Z.Y.': [2873], 'Ganju': [2874], 'J.F.': [2877], 'Schweitzer': [2878], 'Weksler': [2880], '2253-2257Crossref': [2889], 'Briefly,': [2893, 3240], 'Biotechnology).': [2903, 3026, 3119], 'mmMgCl2,': [2924], '20': [2925, 3049, 3078, 3138, 3184, 3295, 3300], 'μm': [2926, 3050, 3139, 3321], 'ATP).': [2927, 3051, 3140], '0.2': [2939], 'μg/μl': [2940], 'Biotechnology)': [2946], 'RT.': [2956], 'terminated': [2960], '12%': [2981, 3193], 'Rabbit': [2987, 3093, 3199], 'IgG': [2988, 3094, 3200], 'unstimulated': [3006], '(p44/42)': [3018], 'MgCl2and': [3048], '7': [3061], 'myelin': [3064], 'basic': [3065], '(Upstate': [3067], 'Biotechnology,': [3068], 'Lake': [3069], 'Placid,': [3070], 'NY)': [3071], '15%': [3087], 'MKK-1': [3102, 3113, 3163], 'MKK-4': [3104, 3115, 3176], 'immunoprecipitates': [3121], '1.0': [3150, 3166], 'p42': [3154], 'Cruz)': [3160, 3173], 'protein-(1–384)': [3171], 'assay,': [3177], '(36Derman': [3214, 4230], 'M.P.': [3215, 4231], 'Chen': [3216, 3983, 4132, 4232], 'J.Y.': [3217, 4233], 'Spokes': [3218, 4234], 'K.C.': [3219, 4235], 'Songyang': [3220, 4236], 'Cantley': [3222, 4238, 4299], 'L.G.': [3223, 4239], '4251-4255Abstract': [3229, 4245], '(59)': [3237, 4253], 'equal': [3241], 'either': [3251], 'class-matched': [3256], 'IgG.': [3258], 'Nonspecific': [3259], 'washing': [3264], 'followed': [3276, 3373], '0.5': [3278, 3282], 'Tris': [3280], 'lithium': [3284], 'chloride': [3285], 'TE': [3289, 3298], 'buffer.': [3290], 'Samples': [3291], 'phosphoinositol': [3303], '(10': [3304], 'μg,': [3305], 'Avanti': [3306], 'Polar': [3307], 'Lipids,': [3308], 'Alabaster,': [3309], 'AL),': [3310], 'ATP': [3315], 'mix': [3316], 'ATP,': [3322], 'μmMgCl2,': [3324], '[γ-32P]ATP)': [3329], '60': [3343], 'HCl': [3348], '160': [3350], 'chloroform:methanol': [3353], '(1:1': [3354], 'v/v).': [3355], 'Lipids': [3356], 'oxalate-impregnated': [3360], 'silica': [3361], 'TLC': [3362], 'plates': [3363, 3386], 'solvent': [3366], 'chloroform:methanol:water:ammonium': [3369], 'hydroxide': [3370], '(20%)': [3371], '(35:35:3.5:7),': [3372], 'autoradiography': [3375], '−80': [3377], 'chemotaxis': [3380, 3487, 4225], '24-well': [3385], '5-μm': [3388], 'porosity': [3389], 'inserts': [3390], '(Costar': [3391], 'Corp.,': [3392], 'Kennebunk,': [3393], 'ME).': [3394], 'per': [3414], 'H199': [3420], '(1:1)': [3422], '0.5%': [3424], 'bovine': [3425], 'albumin.': [3427], 'added': [3431], 'bottom': [3434, 3453, 4406], 'wells,': [3435], 'onto': [3446], 'inserts.': [3448], 'migrating': [3450], 'collected': [3456], 'after': [3457], '2–4': [3458], 'counted': [3461], 'cytometer.': [3465], 'To': [3466, 3669], 'assess': [3467], 'effect': [3469, 4211, 4540], 'wortmannin': [3471, 4366, 4380], 'wortmannin,': [3484], 'done': [3490], 'above.': [3493], 'Double-stranded': [3494], 'oligonucleotides': [3495], 'consensus': [3498], 'site': [3500], '(5′-AGT': [3503], 'TGA': [3504], 'GGG': [3505], 'GAC': [3506], 'TTT': [3507], 'CCC': [3508], 'AGG': [3509], 'C-3′)': [3510], 'labeled': [3512, 3539], '(3,000': [3515], 'Ci/mmol,': [3516], 'NEN': [3517], 'Life': [3518], 'Science': [3519], 'Products)': [3520], 'polynucleotide': [3522], '(Promega,': [3524], 'Madison,': [3525], 'WI)': [3526], 'according': [3527], 'established': [3529], 'procedures.': [3530], 'extract': [3535], '(0.4': [3541], 'ng,': [3542], '4,400': [3543], 'cpm)': [3544], 'presence': [3552], 'DNA-binding': [3554], '250': [3557], 'ng': [3558], 'poly(dI-dC)': [3560], 'oligomer': [3561], '(Boehringer': [3562], 'Mannheim)': [3563], '(37Yang': [3567], 'Y.M.': [3568], 'Rutberg': [3569], 'S.E.': [3570], 'Luo': [3571], 'F.C.': [3572], 'Spratt': [3573], 'T.E.': [3574], 'Halaban': [3575], 'Ferrone': [3577], 'Ronai': [3579], 'Growth': [3582], 'Differ.': [3583], '4:': [3585], '595-602PubMed': [3586], '7.5%': [3596], 'autoradiographed.': [3600], 'representative': [3605], 'findings': [3607], 'independent': [3610], 'experiments.': [3611], 'Human': [3612], 'cDNA': [3614], 'L1.2.': [3625], 'Untransfected': [3626], 'lines': [3630], 'expression.': [3635], 'As': [3636, 4043, 4187, 4313, 4349], 'Fig.': [3639, 4046, 4190, 4316, 4352, 4518], '1,': [3640], 'high': [3644], 'cells.': [3652, 4517], 'Signal': [3653], 'transduction': [3654], 'ligands': [3659], 'cognate': [3662], 'involves': [3665], 'characteristic': [3666, 3703], 'fluxes.': [3668], 'confirm': [3670], 'expressing': [3676], 'functional': [3677], 'retained': [3681], 'fundamental': [3683], 'property,': [3685], 'fluxes': [3694, 3705], 'monitored': [3696], 'induced': [3702, 4356], '(data': [3711], 'shown).': [3713], 'RAFTK,': [3714, 4199], 'member': [3718], 'family,': [3724], 'growth': [3733], '38Avraham': [3762], 'London': [3764], 'Fu': [3766], 'Ota': [3768], 'Hiregowdara': [3770], 'Li': [3772, 3970, 4119], 'Jiang': [3774], 'Pasztor': [3776], 'L.M.': [3777], 'White': [3778], '270:': [3788, 3843, 3993, 4142], '27742-27751Abstract': [3789], '(325)': [3797], '39Lev': [3800], 'Moreno': [3802, 4426], 'Martinez': [3804, 4428], 'Canoll': [3806, 4430], 'Peles': [3808, 4432], 'Musacchio': [3810, 4434], 'Plowman': [3812, 4436], 'G.D.': [3813, 4437], 'Rudy': [3814, 4438], '376:': [3820, 4444], '737-745Crossref': [3821, 4445], '(1254)': [3824, 4448], '40Sasaki': [3827], 'Nagura': [3829], 'Ishino': [3831], 'Tobioka': [3833], 'Kotani': [3835], 'Sasaki': [3837], '21206-21219Abstract': [3844], 'therefore': [3856, 4170], 'investigated': [3857, 4171, 4209], 'whether': [3858, 4025, 4172], 'rapid': [3867, 4531], 'endogenous': [3870], 'upon': [3878, 4079, 4205], '(Fig.': [3881, 3921, 4373, 4391, 4403, 4549], 'A).': [3883], 'an': [3887, 3903, 3918, 3940, 4221], 'increase': [3888], 'intrinsic': [3891], 'treatment,': [3899], 'which': [3912, 3929, 4556], '(4:1)': [3914], 'exogenous': [3919], 'substrate': [3920], '2,': [3922], 'C).': [3925, 4375, 4553], 'Paxillin': [3926], 'adhesions,': [3934], 'play': [3939], 'important': [3941, 4222], '(41Craig': [3948, 4097], 'S.W.': [3949, 4098], 'Johnson': [3950, 4099], 'R.P.': [3951, 4100], '8:': [3957, 4106, 4306], '74-85Crossref': [3958, 4107], '(248)': [3961, 4110], '42Salgia': [3964, 4113], 'Uemura': [3966, 4115], 'Okuda': [3968, 4117], 'Pisick': [3972, 4121], 'Sattler': [3974, 4123], 'de': [3976, 4125], 'Jong': [3977, 4126], 'Heisterkamp': [3981, 4130], 'L.B.': [3984, 4133], 'Groffen': [3985, 4134], 'Griffin': [3987, 4136], '29145-29150Abstract': [3994, 4143], '(129)': [4002, 4151], '43Schaller': [4005, 4154], 'M.D.': [4006, 4155], 'Parsons': [4007, 4156], 'J.T.': [4008, 4157], 'Mol.': [4009, 4158], 'Cell.': [4010, 4159], '15:': [4013, 4162], '2635-2645Crossref': [4014, 4163], '(502)': [4017, 4166], 'Thus,': [4020], 'sought': [4022], 'investigate': [4024], 'would': [4032], 'result': [4033], 'state': [4039], '3,': [4047], 'B,': [4050, 4193, 4354], 'resulted': [4053, 4528], 'Equivalent': [4062], 'present': [4068, 4399], 'lane': [4071, 4402], '(bottom': [4072], 'panels).': [4073], 'It': [4074, 4408], 'cytokines': [4082], 'adaptor': [4084], 'molecule': [4085], 'associates': [4087, 4195], 'adhesions': [4093], 'enhance': [4095], '4,A': [4191], 'treatment.': [4207], 'activity.': [4217], 'mediator': [4223], 'certain': [4227], 'types': [4229], '44Thelen': [4256], 'Uguccioni': [4258], 'Bosiger': [4260], 'Biochem.': [4262], 'Biophys.': [4263], 'Res.': [4264], 'Commun.': [4265], '217:': [4267], '1255-1262Crossref': [4268], '(90)': [4271], '45Kundra': [4274], 'V.': [4275], 'Escobedo': [4276], 'Kazlauskas': [4278], 'Kim': [4280], 'H.K.': [4281], 'Rhee': [4282], 'S.G.': [4283], 'Williams': [4284], 'L.T.': [4285], 'Zetter': [4286], 'B.R.': [4287], '367:': [4290], '474-476Crossref': [4291], '(399)': [4294], '46Carpenter': [4297], 'C.L.': [4298], 'L.C.': [4300], '153-158Crossref': [4307], '(576)': [4310], 'A,': [4318], 'mediating': [4336], 'examined': [4341], 'inhibitor,': [4347], 'wortmannin.': [4348], 'transfectants,': [4362], 'pretreatment': [4364], 'Further': [4376], 'examination': [4377], 'D).': [4393], 'Equal': [4394], 'D,': [4405], 'panel).': [4407], 'pathway': [4423], '(39Lev': [4424], '47Tokiwa': [4451], 'Lev': [4455], '792-794Crossref': [4462], '(285)': [4465], 'β-chemokine,': [4475], 'MIP-1β,': [4476], 'CCR5': [4482], 'showed': [4508], 'mediates': [4511], '6': [4519], 'Ashows': [4520], 'However,': [4537], 'no': [4538], 'significant': [4539], '6,': [4550], 'Furthermore': [4554], 'MKK-1,': [4555]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2001044562', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 13}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 27}, {'year': 2013, 'cited_by_count': 33}, {'year': 2012, 'cited_by_count': 21}], 'updated_date': '2024-12-25T14:45:53.841814', 'created_date': '2016-06-24'}
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