Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2001035969', 'doi': 'https://doi.org/10.1111/j.1471-4159.2012.07936.x', 'title': 'Early mitochondrial abnormalities in hippocampal neurons cultured from <i>Fmr1</i> pre‐mutation mouse model', 'display_name': 'Early mitochondrial abnormalities in hippocampal neurons cultured from <i>Fmr1</i> pre‐mutation mouse model', 'publication_year': 2012, 'publication_date': '2012-09-28', 'ids': {'openalex': 'https://openalex.org/W2001035969', 'doi': 'https://doi.org/10.1111/j.1471-4159.2012.07936.x', 'mag': '2001035969', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22924671', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3564636'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2012.07936.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3564636?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5086842334', 'display_name': 'Eitan S Kaplan', 'orcid': 'https://orcid.org/0000-0002-9355-324X'}, 'institutions': [{'id': 'https://openalex.org/I4210119046', 'display_name': 'Zero to Three', 'ror': 'https://ror.org/01qvk6016', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210119046']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eitan S. Kaplan', 'raw_affiliation_strings': ['Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA', 'These authors equally contribute to this work.'], 'affiliations': [{'raw_affiliation_string': 'These authors equally contribute to this work.', 'institution_ids': ['https://openalex.org/I4210119046']}, {'raw_affiliation_string': 'Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102827814', 'display_name': 'Zhengyu Cao', 'orcid': 'https://orcid.org/0000-0002-2415-224X'}, 'institutions': [{'id': 'https://openalex.org/I4210119046', 'display_name': 'Zero to Three', 'ror': 'https://ror.org/01qvk6016', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210119046']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhengyu Cao', 'raw_affiliation_strings': ['Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA', 'These authors equally contribute to this work.'], 'affiliations': [{'raw_affiliation_string': 'These authors equally contribute to this work.', 'institution_ids': ['https://openalex.org/I4210119046']}, {'raw_affiliation_string': 'Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042702275', 'display_name': 'Susan Hulsizer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan Hulsizer', 'raw_affiliation_strings': ['Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011023379', 'display_name': 'Flora Tassone', 'orcid': 'https://orcid.org/0000-0002-6388-9180'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Flora Tassone', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA', 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}, {'raw_affiliation_string': 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022152588', 'display_name': 'Robert F. Berman', 'orcid': 'https://orcid.org/0000-0001-8530-3147'}, 'institutions': [{'id': 'https://openalex.org/I4210157890', 'display_name': 'Neurological Surgery', 'ror': 'https://ror.org/04r0gp612', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210157890']}, {'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert F. Berman', 'raw_affiliation_strings': ['Department of Neurological Surgery, School of Medicine, University of California, Davis, California, USA', 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Neurological Surgery, School of Medicine, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I4210157890', 'https://openalex.org/I84218800']}, {'raw_affiliation_string': 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061384110', 'display_name': 'Paul J. Hagerman', 'orcid': 'https://orcid.org/0000-0003-1142-5680'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul J. Hagerman', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA', 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}, {'raw_affiliation_string': 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5062413385', 'display_name': 'Isaac N. Pessah', 'orcid': 'https://orcid.org/0000-0002-8149-588X'}, 'institutions': [{'id': 'https://openalex.org/I84218800', 'display_name': 'University of California, Davis', 'ror': 'https://ror.org/05rrcem69', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84218800']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Isaac N. Pessah', 'raw_affiliation_strings': ['Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA', 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}, {'raw_affiliation_string': 'Medical Investigations of Neurodevelopmental Disorders (MIND) Institute, University of California, Davis, California, USA', 'institution_ids': ['https://openalex.org/I84218800']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5062413385'], 'corresponding_institution_ids': ['https://openalex.org/I84218800'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.582, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 71, 'citation_normalized_percentile': {'value': 0.933244, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '123', 'issue': '4', 'first_page': '613', 'last_page': '621'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11772', 'display_name': 'Molecular Basis of Rett Syndrome and Related Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11772', 'display_name': 'Molecular Basis of Rett Syndrome and Related Disorders', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10301', 'display_name': 'Mitochondrial Dynamics and Reactive Oxygen Species Regulation', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin-Proteasome Proteolytic Pathway', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fmr1', 'display_name': 'FMR1', 'score': 0.8213221}, {'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.6439216}, {'id': 'https://openalex.org/keywords/fragile-x-syndrome', 'display_name': 'Fragile X Syndrome', 'score': 0.516381}], 'concepts': [{'id': 'https://openalex.org/C2779063550', 'wikidata': 'https://www.wikidata.org/wiki/Q905435', 'display_name': 'FMR1', 'level': 4, 'score': 0.8213221}, {'id': 'https://openalex.org/C2777630245', 'wikidata': 'https://www.wikidata.org/wiki/Q221472', 'display_name': 'Fragile X syndrome', 'level': 2, 'score': 0.7961936}, {'id': 'https://openalex.org/C2780906641', 'wikidata': 'https://www.wikidata.org/wiki/Q213373', 'display_name': 'Ataxia', 'level': 2, 'score': 0.7877468}, {'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.6439216}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.6296414}, {'id': 'https://openalex.org/C148762608', 'wikidata': 'https://www.wikidata.org/wiki/Q3748185', 'display_name': 'Hippocampal formation', 'level': 2, 'score': 0.6283573}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6206113}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.47327065}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.44872066}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43646935}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.43174306}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.39790142}, {'id': 'https://openalex.org/C3020422209', 'wikidata': 'https://www.wikidata.org/wiki/Q221472', 'display_name': 'Fragile x', 'level': 3, 'score': 0.34353054}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.28556824}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.27964652}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.27849954}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.13721952}], 'mesh': [{'descriptor_ui': 'D051860', 'descriptor_name': 'Fragile X Mental Retardation Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': True}, {'descriptor_ui': 'D019680', 'descriptor_name': 'Trinucleotide Repeat Expansion', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000704', 'descriptor_name': 'Analysis of Variance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051860', 'descriptor_name': 'Fragile X Mental Retardation Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009930', 'descriptor_name': 'Organic Chemicals', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009930', 'descriptor_name': 'Organic Chemicals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010101', 'descriptor_name': 'Oxygen Consumption', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019680', 'descriptor_name': 'Trinucleotide Repeat Expansion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1471-4159.2012.07936.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S135837084', 'display_name': 'Journal of Neurochemistry', 'issn_l': '0022-3042', 'issn': ['0022-3042', '1471-4159'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3564636', 'pdf_url': 'https://europepmc.org/articles/pmc3564636?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564636', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22924671', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3564636', 'pdf_url': 'https://europepmc.org/articles/pmc3564636?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.51}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1496952679', 'https://openalex.org/W1596618358', 'https://openalex.org/W1982268520', 'https://openalex.org/W1984067201', 'https://openalex.org/W1985501728', 'https://openalex.org/W1989565891', 'https://openalex.org/W1990857335', 'https://openalex.org/W1997941464', 'https://openalex.org/W2001761047', 'https://openalex.org/W2002358253', 'https://openalex.org/W2005078842', 'https://openalex.org/W2005956966', 'https://openalex.org/W2012322293', 'https://openalex.org/W2018716517', 'https://openalex.org/W2024771344', 'https://openalex.org/W2026014206', 'https://openalex.org/W2037557110', 'https://openalex.org/W2045085957', 'https://openalex.org/W2047460306', 'https://openalex.org/W2049533446', 'https://openalex.org/W2049763495', 'https://openalex.org/W2053826038', 'https://openalex.org/W2053985384', 'https://openalex.org/W2054591037', 'https://openalex.org/W2055572268', 'https://openalex.org/W2059502738', 'https://openalex.org/W2064685053', 'https://openalex.org/W2065762280', 'https://openalex.org/W2088795096', 'https://openalex.org/W2095239381', 'https://openalex.org/W2099064674', 'https://openalex.org/W2101692941', 'https://openalex.org/W2117874342', 'https://openalex.org/W2117973743', 'https://openalex.org/W2122033671', 'https://openalex.org/W2123499700', 'https://openalex.org/W2129698270', 'https://openalex.org/W2130558981', 'https://openalex.org/W2135389676', 'https://openalex.org/W2138660056', 'https://openalex.org/W2143106924', 'https://openalex.org/W2143798904', 'https://openalex.org/W2144550671', 'https://openalex.org/W2144917811', 'https://openalex.org/W2150021890', 'https://openalex.org/W2150200318', 'https://openalex.org/W2150486823', 'https://openalex.org/W2150625710', 'https://openalex.org/W2153985163', 'https://openalex.org/W2162686750', 'https://openalex.org/W2166353621', 'https://openalex.org/W2167311801', 'https://openalex.org/W2170083175', 'https://openalex.org/W2403600324', 'https://openalex.org/W4246017678', 'https://openalex.org/W4297810568'], 'related_works': ['https://openalex.org/W4300497241', 'https://openalex.org/W2789548112', 'https://openalex.org/W2610363742', 'https://openalex.org/W2508482193', 'https://openalex.org/W223852733', 'https://openalex.org/W2129698270', 'https://openalex.org/W2096167627', 'https://openalex.org/W2085938114', 'https://openalex.org/W2083700082', 'https://openalex.org/W1989565891'], 'abstract_inverted_index': {'Abstract': [0], 'Pre‐mutation': [1], 'CGG': [2, 6, 9, 53, 67, 104, 109, 135, 156, 171, 210], 'repeat': [3], 'expansions': [4], '(55–200': [5], 'repeats;': [7], 'pre‐': [8, 52, 66, 103, 170, 209], ')': [10, 19, 49, 57], 'within': [11], 'the': [12, 114, 141, 195, 205, 214], 'fragile‐X': [13, 43, 82], 'mental': [14, 44], 'retardation': [15, 45], '1': [16], '(': [17, 47, 55], 'FMR1': [18], 'gene': [20], 'cause': [21], 'fragile‐X‐associated': [22, 219], 'tremor/ataxia': [23, 220], 'syndrome': [24, 83], 'in': [25, 28, 50, 77, 125, 131, 140, 187, 208], 'humans.': [26], 'Defects': [27], 'neuronal': [29, 68, 100], 'morphology,': [30], 'early': [31, 151, 206], 'migration,': [32], 'and': [33, 64, 117, 144, 163, 180, 190, 201, 212], 'electrophysiological': [34], 'activity': [35], 'have': [36], 'been': [37], 'described': [38], 'despite': [39, 194], 'appreciable': [40, 198], 'expression': [41, 200], 'of': [42, 75, 81, 90, 113, 147, 153, 176, 197, 216], 'protein': [46], 'FMRP': [48, 76, 115, 199], 'a': [51, 78], 'knock‐in': [54], 'KI': [56, 105], 'mouse': [58], 'model.': [59], 'The': [60, 73], 'triggers': [61], 'that': [62, 97, 123, 185], 'initiate': [63], 'promote': [65], 'dysfunction': [69], 'are': [70], 'not': [71], 'understood.': [72], 'absence': [74], 'Drosophila': [79], 'model': [80], 'was': [84], 'shown': [85], 'to': [86, 204, 213], 'increase': [87], 'axonal': [88], 'transport': [89], 'mitochondria.': [91], 'In': [92, 168], 'this': [93, 150], 'study,': [94], 'we': [95], 'show': [96, 138], 'dissociated': [98], 'hippocampal': [99, 136, 157], 'culture': [101], 'from': [102], 'mice': [106], '(average': [107], '170': [108], 'repeats)': [110], 'express': [111], '42.6%': [112], 'levels': [116], '3.8‐fold': [118], 'higher': [119, 174], 'Fmr1': [120], 'mRNA': [121], 'than': [122], 'measured': [124], 'wild‐type': [126], 'neurons': [127, 137, 172], 'at': [128, 149], '4': [129], 'days': [130], 'vitro': [132], '.': [133], 'Pre‐': [134, 155], 'abnormalities': [139], 'number,': [142], 'mobility,': [143], 'metabolic': [145, 191], 'function': [146, 192], 'mitochondria': [148, 162, 166], 'stage': [152], 'differentiation.': [154], 'neurites': [158], 'contained': [159], 'significantly': [160], 'fewer': [161], 'greatly': [164], 'reduced': [165], 'mobility.': [167], 'addition,': [169], 'had': [173], 'rates': [175], 'basal': [177], 'oxygen': [178], 'consumption': [179], 'proton': [181], 'leak.': [182], 'We': [183], 'conclude': [184], 'deficits': [186], 'mitochondrial': [188], 'trafficking': [189], 'occur': [193], 'presence': [196], 'may': [202], 'contribute': [203], 'pathophysiology': [207], 'carriers': [211], 'risk': [215], 'developing': [217], 'clinical': [218], 'syndrome.': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2001035969', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 17}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 4}], 'updated_date': '2024-08-21T15:27:11.673514', 'created_date': '2016-06-24'}