Expression of nuclear insulin receptor substrate 1 in breast cancer

Name: Work Video:
Duration: 3 min 30 s
Diego Sisci; Catia Morelli; Cecilia Garofalo; Francesco Romeo; Lucio Morabito; Filomena Casaburi; Emilia Middea; Sandra Cascio; Elvira Brunelli; Sebastiano Andò; Eva Surmacz
{'id': 'https://openalex.org/W2001012596', 'doi': 'https://doi.org/10.1136/jcp.2006.039107', 'title': 'Expression of nuclear insulin receptor substrate 1 in breast cancer', 'display_name': 'Expression of nuclear insulin receptor substrate 1 in breast cancer', 'publication_year': 2006, 'publication_date': '2006-08-01', 'ids': {'openalex': 'https://openalex.org/W2001012596', 'doi': 'https://doi.org/10.1136/jcp.2006.039107', 'mag': '2001012596', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16882697', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1955087'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1136/jcp.2006.039107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S37362813', 'display_name': 'Journal of Clinical Pathology', 'issn_l': '0021-9746', 'issn': ['0021-9746', '1472-4146'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1955087?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5011806303', 'display_name': 'Diego Sisci', 'orcid': 'https://orcid.org/0000-0001-6577-1541'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Diego Sisci', 'raw_affiliation_strings': ['Department of Pharmaco-Biology, University of Calabria, Arcavacata di Rende, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaco-Biology, University of Calabria, Arcavacata di Rende, Italy', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008537289', 'display_name': 'Catia Morelli', 'orcid': 'https://orcid.org/0000-0002-9407-0805'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Catia Morelli', 'raw_affiliation_strings': ['University of Calabria'], 'affiliations': [{'raw_affiliation_string': 'University of Calabria', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072885632', 'display_name': 'Cecilia Garofalo', 'orcid': 'https://orcid.org/0000-0001-5334-8930'}, 'institutions': [{'id': 'https://openalex.org/I4210121742', 'display_name': 'Istituto Ortopedico Rizzoli', 'ror': 'https://ror.org/02ycyys66', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121742', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Cecilia Garofalo', 'raw_affiliation_strings': ['Istituti Ortopedici Rizzoli'], 'affiliations': [{'raw_affiliation_string': 'Istituti Ortopedici Rizzoli', 'institution_ids': ['https://openalex.org/I4210121742']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104477127', 'display_name': 'Francesco Romeo', 'orcid': 'https://orcid.org/0000-0001-6322-7374'}, 'institutions': [{'id': 'https://openalex.org/I4210149564', 'display_name': 'Ospedale SS. Annunziata', 'ror': 'https://ror.org/04hd4qy94', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210149564']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Romeo', 'raw_affiliation_strings': ['Annunziata Hospital'], 'affiliations': [{'raw_affiliation_string': 'Annunziata Hospital', 'institution_ids': ['https://openalex.org/I4210149564']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010613445', 'display_name': 'Lucio Morabito', 'orcid': 'https://orcid.org/0000-0002-3693-0483'}, 'institutions': [{'id': 'https://openalex.org/I4210149564', 'display_name': 'Ospedale SS. Annunziata', 'ror': 'https://ror.org/04hd4qy94', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210149564']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Lucio Morabito', 'raw_affiliation_strings': ['Annunziata Hospital'], 'affiliations': [{'raw_affiliation_string': 'Annunziata Hospital', 'institution_ids': ['https://openalex.org/I4210149564']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5096779140', 'display_name': 'Filomena Casaburi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210149564', 'display_name': 'Ospedale SS. Annunziata', 'ror': 'https://ror.org/04hd4qy94', 'country_code': 'IT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210149564']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Filomena Casaburi', 'raw_affiliation_strings': ['Annunziata Hospital'], 'affiliations': [{'raw_affiliation_string': 'Annunziata Hospital', 'institution_ids': ['https://openalex.org/I4210149564']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015606712', 'display_name': 'Emilia Middea', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Emilia Middea', 'raw_affiliation_strings': ['University of Calabria'], 'affiliations': [{'raw_affiliation_string': 'University of Calabria', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044100185', 'display_name': 'Sandra Cascio', 'orcid': 'https://orcid.org/0000-0003-4234-0508'}, 'institutions': [{'id': 'https://openalex.org/I84392919', 'display_name': 'Temple University', 'ror': 'https://ror.org/00kx1jb78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84392919']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sandra Cascio', 'raw_affiliation_strings': ['[Temple University]'], 'affiliations': [{'raw_affiliation_string': '[Temple University]', 'institution_ids': ['https://openalex.org/I84392919']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020730032', 'display_name': 'Elvira Brunelli', 'orcid': 'https://orcid.org/0000-0003-3669-1395'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Elvira Brunelli', 'raw_affiliation_strings': ['University of Calabria'], 'affiliations': [{'raw_affiliation_string': 'University of Calabria', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102010816', 'display_name': 'Sebastiano Andò', 'orcid': 'https://orcid.org/0000-0002-5412-7045'}, 'institutions': [{'id': 'https://openalex.org/I45204951', 'display_name': 'University of Calabria', 'ror': 'https://ror.org/02rc97e94', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I45204951']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sebastiano Andò', 'raw_affiliation_strings': ['University of Calabria'], 'affiliations': [{'raw_affiliation_string': 'University of Calabria', 'institution_ids': ['https://openalex.org/I45204951']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053145771', 'display_name': 'Eva Surmacz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I84392919', 'display_name': 'Temple University', 'ror': 'https://ror.org/00kx1jb78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I84392919']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eva Surmacz', 'raw_affiliation_strings': ['[Temple University]'], 'affiliations': [{'raw_affiliation_string': '[Temple University]', 'institution_ids': ['https://openalex.org/I84392919']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.036, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.953424, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '60', 'issue': '6', 'first_page': '633', 'last_page': '641'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10748', 'display_name': 'Growth Hormone and Insulin-like Growth Factors', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lobular-carcinoma', 'display_name': 'Lobular carcinoma', 'score': 0.53126943}, {'id': 'https://openalex.org/keywords/progesterone-receptor', 'display_name': 'Progesterone receptor', 'score': 0.44873577}], 'concepts': [{'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.6930797}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5673426}, {'id': 'https://openalex.org/C2779296616', 'wikidata': 'https://www.wikidata.org/wiki/Q6663895', 'display_name': 'Lobular carcinoma', 'level': 5, 'score': 0.53126943}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.51893544}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.5162751}, {'id': 'https://openalex.org/C2778001805', 'wikidata': 'https://www.wikidata.org/wiki/Q189961', 'display_name': 'Mammary gland', 'level': 4, 'score': 0.47212538}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4596571}, {'id': 'https://openalex.org/C2780862961', 'wikidata': 'https://www.wikidata.org/wiki/Q5311598', 'display_name': 'Ductal carcinoma', 'level': 4, 'score': 0.45516312}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.45170298}, {'id': 'https://openalex.org/C98717036', 'wikidata': 'https://www.wikidata.org/wiki/Q14872994', 'display_name': 'Progesterone receptor', 'level': 5, 'score': 0.44873577}, {'id': 'https://openalex.org/C112446052', 'wikidata': 'https://www.wikidata.org/wiki/Q422579', 'display_name': 'Insulin receptor', 'level': 4, 'score': 0.42552808}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.39669362}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39308852}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34447962}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.33149034}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.26532298}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.085754424}], 'mesh': [{'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000369', 'descriptor_name': 'Aged, 80 and over', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014408', 'descriptor_name': 'Biomarkers, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018270', 'descriptor_name': 'Carcinoma, Ductal, Breast', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018270', 'descriptor_name': 'Carcinoma, Ductal, Breast', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018270', 'descriptor_name': 'Carcinoma, Ductal, Breast', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018275', 'descriptor_name': 'Carcinoma, Lobular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018275', 'descriptor_name': 'Carcinoma, Lobular', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018275', 'descriptor_name': 'Carcinoma, Lobular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002467', 'descriptor_name': 'Cell Nucleus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D047628', 'descriptor_name': 'Estrogen Receptor alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007124', 'descriptor_name': 'Immunoenzyme Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055504', 'descriptor_name': 'Insulin Receptor Substrate Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042361', 'descriptor_name': 'Mammary Glands, Human', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042361', 'descriptor_name': 'Mammary Glands, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018613', 'descriptor_name': 'Microscopy, Confocal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1136/jcp.2006.039107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S37362813', 'display_name': 'Journal of Clinical Pathology', 'issn_l': '0021-9746', 'issn': ['0021-9746', '1472-4146'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319945', 'host_organization_name': 'BMJ', 'host_organization_lineage': ['https://openalex.org/P4310319945'], 'host_organization_lineage_names': ['BMJ'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1955087', 'pdf_url': 'https://europepmc.org/articles/pmc1955087?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955087', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16882697', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1955087', 'pdf_url': 'https://europepmc.org/articles/pmc1955087?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.84, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 58, 'referenced_works': ['https://openalex.org/W1491807376', 'https://openalex.org/W1497802607', 'https://openalex.org/W1526859945', 'https://openalex.org/W1605681980', 'https://openalex.org/W1606372667', 'https://openalex.org/W1662062786', 'https://openalex.org/W170478967', 'https://openalex.org/W1836718508', 'https://openalex.org/W1848388033', 'https://openalex.org/W1853387493', 'https://openalex.org/W1856518222', 'https://openalex.org/W1868901579', 'https://openalex.org/W1969898679', 'https://openalex.org/W1973372369', 'https://openalex.org/W1978173438', 'https://openalex.org/W1987172765', 'https://openalex.org/W1987249192', 'https://openalex.org/W1990430867', 'https://openalex.org/W1992462321', 'https://openalex.org/W1997006452', 'https://openalex.org/W2003990124', 'https://openalex.org/W2009468514', 'https://openalex.org/W2014205300', 'https://openalex.org/W2015524046', 'https://openalex.org/W2022120508', 'https://openalex.org/W2032095724', 'https://openalex.org/W2038038133', 'https://openalex.org/W2038431178', 'https://openalex.org/W2038648908', 'https://openalex.org/W2039095226', 'https://openalex.org/W2042473840', 'https://openalex.org/W2052841818', 'https://openalex.org/W2056239941', 'https://openalex.org/W2056950301', 'https://openalex.org/W2057524003', 'https://openalex.org/W2071892147', 'https://openalex.org/W2072787342', 'https://openalex.org/W2076054059', 'https://openalex.org/W2080069637', 'https://openalex.org/W2081729700', 'https://openalex.org/W2085490118', 'https://openalex.org/W2087258136', 'https://openalex.org/W2087729478', 'https://openalex.org/W2091947586', 'https://openalex.org/W2094657679', 'https://openalex.org/W2098601481', 'https://openalex.org/W2121943809', 'https://openalex.org/W2125262485', 'https://openalex.org/W2127612231', 'https://openalex.org/W2131391645', 'https://openalex.org/W2137395664', 'https://openalex.org/W2143963955', 'https://openalex.org/W2153767954', 'https://openalex.org/W2153912877', 'https://openalex.org/W2233719657', 'https://openalex.org/W2413866934', 'https://openalex.org/W4236804608', 'https://openalex.org/W4247870523'], 'related_works': ['https://openalex.org/W2783709702', 'https://openalex.org/W2367178024', 'https://openalex.org/W2265439652', 'https://openalex.org/W2223378540', 'https://openalex.org/W2128153090', 'https://openalex.org/W2101363204', 'https://openalex.org/W2095698778', 'https://openalex.org/W2078024151', 'https://openalex.org/W2041889021', 'https://openalex.org/W1986360904'], 'abstract_inverted_index': {'Background:': [0], 'Insulin': [1], 'receptor': [2, 41], 'substrate': [3], '1': [4, 18], '(IRS-1),': [5], 'a': [6, 251, 259], 'cytoplasmic': [7], 'protein': [8], 'transmitting': [9], 'signals': [10], 'from': [11], 'the': [12, 36, 48, 92], 'insulin': [13], 'and': [14, 38, 73, 77, 99, 115, 136, 147, 163, 165, 170, 178, 183, 191, 202, 212, 222, 233, 248, 257], 'insulin-like': [15], 'growth': [16], 'factor': [17], 'receptors,': [19], 'has': [20, 58], 'been': [21, 60], 'implicated': [22], 'in': [23, 45, 53, 70, 130, 138, 154, 187, 199, 230, 238], 'breast': [24, 54, 71, 255], 'cancer.': [25, 240], 'Previously,': [26], 'it': [27, 79], 'was': [28, 102, 125, 228], 'reported': [29], 'that': [30], 'IRS-1': [31, 52, 67, 98, 123, 182, 211, 227, 247], 'can': [32], 'be': [33, 128], 'translocated': [34], 'to': [35, 127], 'nucleus': [37], 'modulate': [39], 'oestrogen': [40], 'α': [42], '(ERα)': [43], 'activity': [44], 'vitro.': [46], 'However,': [47], 'expression': [49, 93, 101, 124, 153], 'of': [50, 94], 'nuclear': [51, 66, 122, 210, 246], 'cancer': [55, 72, 160, 167, 189, 201, 256], 'biopsy': [56], 'specimens': [57, 232], 'never': [59], 'examined.': [61], 'Aims:': [62], 'To': [63], 'assess': [64], 'whether': [65, 78], 'is': [68, 250], 'present': [69], 'non-cancer': [74], 'mammary': [75, 132, 204], 'epithelium,': [76, 156], 'correlates': [80], 'with': [81, 216, 236], 'other': [82], 'markers,': [83], 'especially': [84], 'ERα.': [85], 'Parallel': [86], 'studies': [87], 'were': [88, 108, 172, 196], 'carried': [89], 'out': [90], 'for': [91, 253], 'cytoplasmatic': [95], 'IRS-1.': [96], 'Methods:': [97], 'ERα': [100, 152, 184, 213, 237, 249], 'assessed': [103], 'by': [104], 'immunohistochemical': [105], 'analysis.': [106, 119], 'Data': [107], 'evaluated': [109], 'using': [110], 'Pearson’s': [111], 'correlation,': [112], 'linear': [113], 'regression': [114], 'receiver': [116], 'operating': [117], 'characteristic': [118, 252], 'Results:': [120], 'Median': [121, 151], 'found': [126], 'low': [129], 'normal': [131, 155, 203], 'epithelial': [133], 'cells': [134], '(1.6%)': [135], 'high': [137], 'benign': [139, 157, 192], 'tumours': [140, 193], '(20.5%),': [141], 'ductal': [142, 159, 188, 207, 239, 254], 'grade': [143, 161, 168], '2': [144, 162, 169], 'carcinoma': [145, 149], '(11.0%)': [146], 'lobular': [148, 166, 200], '(∼30%).': [150], 'tumours,': [158], '3,': [164], '3': [171], '10.5,': [173], '20.5,': [174], '65.0,': [175], '0.0,': [176], '80': [177], '15%,': [179], 'respectively.': [180], 'Nuclear': [181], 'positively': [185, 234], 'correlated': [186, 215, 235], '(p&lt;0.001)': [190], '(p&lt;0.01),': [194], 'but': [195], 'not': [197], 'associated': [198], 'epithelium.': [205], 'In': [206], 'carcinoma,': [208], 'both': [209], 'negatively': [214], 'tumour': [217], 'grade,': [218], 'size,': [219], 'mitotic': [220], 'index': [221], 'lymph': [223], 'node': [224], 'involvement.': [225], 'Cytoplasmic': [226], 'expressed': [229], 'all': [231], 'Conclusions:': [241], 'A': [242], 'positive': [243], 'association': [244], 'between': [245], 'marks': [258], 'more': [260], 'differentiated,': [261], 'non-metastatic': [262], 'phenotype.': [263]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2001012596', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-16T01:32:37.997748', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
