Title: Composition of plasma and nascent very low density lipoprotein from perfused livers of hypercholesterolemic squirrel monkeys
Abstract: Abstract The composition of circulating very low density lipoprotein (VLDL) was compared with the composition and secretion of nascent VLDL from perfused livers of squirrel monkeys that were fed unsaturated or saturated fat diets to elicit different degrees of plasma hypercholesterolemia. All squirrel monkeys studied had cholesteryl ester‐rich plasma VLDL, although greater enrichment occurred in hypercholesterolemic animals fed saturated fat. Livers from hypercholesterolemic animals were capable of secreting VLDL particles enriched in cholesteryl ester, suggesting hepatic origin for a portion of this circulating lipid moiety. Total VLDL lipid, but not protein output by perfused livers of hypercholesterolemic monkeys, was greater than that by livers from hypocholesterolemic animals. These results indicate that saturated fat‐induced hypercholesterolemia is associated with changes in the composition of hepatic VLDL in the squirrel monkey.
Publication Year: 1980
Publication Date: 1980-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 14
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot