Title: Effect of Hydrocortisone and Corticotropin on Glucose-Induced Insulin and Proinsulin Secretion in Man
Abstract: The total immunoreactive insulin (TIR) and proinsulin-like material (IRP) were studied in response to oral glucose in 12 young (22–30) normal lean volunteers during 4-hr infusion of β1–24 corticotropin or after 3 days of treatment with 80 mg of hydrocortisone. Corticotropin produced no increase in baseline glucose or plasma glucose in response to oral glucose, compared to the control. The baseline or glucoseinduced TIR and IRP were not markedly different in the corticotropin and the control group. Hydrocortisone treatment produced a significant increase in baseline glucose without increase in TIR or IRP. In contrast, glucose-induced TIR and IRP were significantly increased at 60, 90, and 120 min. Increment of glucose, TIR and IRP above the baseline in subjects with cortisol therapy over the control, increased by 176, 165, and 306%, respectively. These studies suggest that: 1) Corticotropin has no significant effect on baseline or glucoseinduced TIR and IRP in man. 2) Cortisol therapy induces hyperglycemia in response to glucose in normal subjects. This hyperglycemia is accompanied by hyperinsulinemia as well as hyperproinsulinemia. 3) The hyperinsulinemia of cortisol therapy cannot be solely ascribed to increased proinsulin.
Publication Year: 1973
Publication Date: 1973-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 26
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