Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2000670596', 'doi': 'https://doi.org/10.1002/jcb.20767', 'title': 'Effects of 24R,25‐ and 1α,25‐dihydroxyvitamin D<sub>3</sub> on mineralizing growth plate chondrocytes', 'display_name': 'Effects of 24R,25‐ and 1α,25‐dihydroxyvitamin D<sub>3</sub> on mineralizing growth plate chondrocytes', 'publication_year': 2006, 'publication_date': '2006-01-11', 'ids': {'openalex': 'https://openalex.org/W2000670596', 'doi': 'https://doi.org/10.1002/jcb.20767', 'mag': '2000670596', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16408294'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.20767', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071219180', 'display_name': 'Luojia Wu', 'orcid': 'https://orcid.org/0009-0007-8239-2683'}, 'institutions': [{'id': 'https://openalex.org/I155781252', 'display_name': 'University of South Carolina', 'ror': 'https://ror.org/02b6qw903', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I155781252']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L.N.Y. Wu', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208', 'institution_ids': ['https://openalex.org/I155781252']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060346248', 'display_name': 'Brian R. Genge', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I155781252', 'display_name': 'University of South Carolina', 'ror': 'https://ror.org/02b6qw903', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I155781252']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'B.R. Genge', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208', 'institution_ids': ['https://openalex.org/I155781252']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040576089', 'display_name': 'Yoshinori Ishikawa', 'orcid': 'https://orcid.org/0000-0001-6697-4527'}, 'institutions': [{'id': 'https://openalex.org/I155781252', 'display_name': 'University of South Carolina', 'ror': 'https://ror.org/02b6qw903', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I155781252']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Y. Ishikawa', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208', 'institution_ids': ['https://openalex.org/I155781252']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101529744', 'display_name': 'Tetsuya Ishikawa', 'orcid': 'https://orcid.org/0000-0003-2765-5165'}, 'institutions': [{'id': 'https://openalex.org/I155781252', 'display_name': 'University of South Carolina', 'ror': 'https://ror.org/02b6qw903', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I155781252']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'T. Ishikawa', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208', 'institution_ids': ['https://openalex.org/I155781252']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109997080', 'display_name': 'Roy E. Wuthier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I155781252', 'display_name': 'University of South Carolina', 'ror': 'https://ror.org/02b6qw903', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I155781252']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R.E. Wuthier', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, University of South Carolina, 329 Graduate Science Research Center, Columbia, SC 29208', 'institution_ids': ['https://openalex.org/I155781252']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4640, 'currency': 'USD', 'value_usd': 4640, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.649379, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 80}, 'biblio': {'volume': '98', 'issue': '2', 'first_page': '309', 'last_page': '334'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D Research Studies', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10277', 'display_name': 'Vitamin D Research Studies', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13453', 'display_name': 'Alkaline Phosphatase Research Studies', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11399', 'display_name': 'Muscle metabolism and nutrition', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C160160445', 'wikidata': 'https://www.wikidata.org/wiki/Q24769688', 'display_name': 'Alkaline phosphatase', 'level': 3, 'score': 0.7540628}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.6250975}, {'id': 'https://openalex.org/C2777318727', 'wikidata': 'https://www.wikidata.org/wiki/Q409464', 'display_name': 'Lactate dehydrogenase', 'level': 3, 'score': 0.6112671}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5500041}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.4835953}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.46622112}, {'id': 'https://openalex.org/C519063684', 'wikidata': 'https://www.wikidata.org/wiki/Q706', 'display_name': 'Calcium', 'level': 2, 'score': 0.46526173}, {'id': 'https://openalex.org/C1008401', 'wikidata': 'https://www.wikidata.org/wiki/Q184681', 'display_name': 'Anabolism', 'level': 2, 'score': 0.4259417}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.413894}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.39269978}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.35515633}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.32673576}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.2719107}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.26246136}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.085866004}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015650', 'descriptor_name': '24,25-Dihydroxyvitamin D 3', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D006132', 'descriptor_name': 'Growth Plate', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D015650', 'descriptor_name': '24,25-Dihydroxyvitamin D 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000469', 'descriptor_name': 'Alkaline Phosphatase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000469', 'descriptor_name': 'Alkaline Phosphatase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002113', 'descriptor_name': 'Calcification, Physiologic', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D002113', 'descriptor_name': 'Calcification, Physiologic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002113', 'descriptor_name': 'Calcification, Physiologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019902', 'descriptor_name': 'Chondrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006132', 'descriptor_name': 'Growth Plate', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006132', 'descriptor_name': 'Growth Plate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007770', 'descriptor_name': 'L-Lactate Dehydrogenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011509', 'descriptor_name': 'Proteoglycans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014807', 'descriptor_name': 'Vitamin D', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcb.20767', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53807158', 'display_name': 'Journal of Cellular Biochemistry', 'issn_l': '0730-2312', 'issn': ['0730-2312', '1097-4644'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16408294', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.79, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 89, 'referenced_works': ['https://openalex.org/W1513120850', 'https://openalex.org/W1515651002', 'https://openalex.org/W1527157268', 'https://openalex.org/W1533065115', 'https://openalex.org/W1541236401', 'https://openalex.org/W1544995067', 'https://openalex.org/W1553049056', 'https://openalex.org/W1579204819', 'https://openalex.org/W1592117307', 'https://openalex.org/W1592266646', 'https://openalex.org/W1600621582', 'https://openalex.org/W1607423821', 'https://openalex.org/W173954074', 'https://openalex.org/W1775749144', 'https://openalex.org/W1835352686', 'https://openalex.org/W1904889669', 'https://openalex.org/W1912410317', 'https://openalex.org/W1965551846', 'https://openalex.org/W1981296594', 'https://openalex.org/W1981966393', 'https://openalex.org/W1983619077', 'https://openalex.org/W1984355752', 'https://openalex.org/W1985650583', 'https://openalex.org/W1990019150', 'https://openalex.org/W1991686564', 'https://openalex.org/W1991686744', 'https://openalex.org/W1993800888', 'https://openalex.org/W1994133913', 'https://openalex.org/W1995880743', 'https://openalex.org/W2001721443', 'https://openalex.org/W2002201489', 'https://openalex.org/W2008499280', 'https://openalex.org/W2008544782', 'https://openalex.org/W2010246412', 'https://openalex.org/W2012716377', 'https://openalex.org/W2015346965', 'https://openalex.org/W2016026391', 'https://openalex.org/W2016752237', 'https://openalex.org/W2019726191', 'https://openalex.org/W2021255396', 'https://openalex.org/W2024161743', 'https://openalex.org/W2025235378', 'https://openalex.org/W2025740625', 'https://openalex.org/W2026485120', 'https://openalex.org/W2027262385', 'https://openalex.org/W2030686657', 'https://openalex.org/W2030709706', 'https://openalex.org/W2030889078', 'https://openalex.org/W2031420609', 'https://openalex.org/W2033713152', 'https://openalex.org/W2040057440', 'https://openalex.org/W2042187005', 'https://openalex.org/W2049769334', 'https://openalex.org/W2053766591', 'https://openalex.org/W2053867930', 'https://openalex.org/W2054622865', 'https://openalex.org/W2055338487', 'https://openalex.org/W2057421373', 'https://openalex.org/W2058628090', 'https://openalex.org/W2062361583', 'https://openalex.org/W2064182974', 'https://openalex.org/W2064689399', 'https://openalex.org/W2069949260', 'https://openalex.org/W2077333933', 'https://openalex.org/W2078066159', 'https://openalex.org/W2078509120', 'https://openalex.org/W2078582195', 'https://openalex.org/W2079446903', 'https://openalex.org/W2079903643', 'https://openalex.org/W2080006650', 'https://openalex.org/W2080032941', 'https://openalex.org/W2091213093', 'https://openalex.org/W2095704190', 'https://openalex.org/W2098657941', 'https://openalex.org/W2120055794', 'https://openalex.org/W2128342505', 'https://openalex.org/W2130060360', 'https://openalex.org/W2138033100', 'https://openalex.org/W2139075512', 'https://openalex.org/W2141678715', 'https://openalex.org/W2170919347', 'https://openalex.org/W2280222809', 'https://openalex.org/W2339872073', 'https://openalex.org/W2398619995', 'https://openalex.org/W2416854425', 'https://openalex.org/W2418225535', 'https://openalex.org/W2743325046', 'https://openalex.org/W322800605', 'https://openalex.org/W4238176521'], 'related_works': ['https://openalex.org/W4211036289', 'https://openalex.org/W3215508502', 'https://openalex.org/W2952941127', 'https://openalex.org/W2884063071', 'https://openalex.org/W2621286599', 'https://openalex.org/W2292138362', 'https://openalex.org/W2163350691', 'https://openalex.org/W2063672911', 'https://openalex.org/W2035326542', 'https://openalex.org/W190756422'], 'abstract_inverted_index': {'Abstract': [0], 'Time‐': [1], 'and': [2, 10, 20, 69, 74, 76, 104, 128, 133, 218, 248, 271, 297, 349], 'dosage‐dependent': [3, 213], 'effects': [4, 168, 181, 267, 279, 325], 'of': [5, 18, 94, 126, 169, 182, 215, 234, 239, 326, 351, 356], '1,25(OH)': [6, 111, 138, 183, 206, 240, 285, 311], '2': [7, 12, 96, 112, 139, 147, 161, 171, 184, 207, 241, 254, 286, 312, 328], 'D': [8, 13, 97, 113, 140, 148, 162, 172, 185, 208, 242, 255, 287, 313, 329], '3': [9, 14, 98, 114, 141, 149, 163, 173, 186, 209, 243, 256, 288, 314, 330], '24,25(OH)': [11, 95, 146, 160, 170, 253, 327], 'on': [15], 'primary': [16], 'cultures': [17, 88], 'pre‐': [19], 'post‐confluent': [21], 'avian': [22], 'growth': [23], 'plate': [24], '(GP)': [25], 'chondrocytes': [26], 'were': [27, 30, 84, 154, 187, 194, 268], 'examined.': [28], 'Cultures': [29], 'grown': [31, 89], 'in': [32, 80, 90, 118, 190, 197, 204, 291, 353, 369], 'either': [33], 'a': [34, 48, 275], 'serum‐containing': [35, 175, 198], 'culture': [36, 177], 'medium': [37], 'designed': [38], 'to': [39, 130, 159, 201, 303, 359], 'closely': [40], 'mimic': [41], 'normal': [42], 'GP': [43, 360], 'extracellular': [44, 82], 'fluid': [45], '(DATP5)': [46], 'or': [47], 'commercially': [49], 'available': [50], 'serum‐free': [51, 191], 'media': [52], '(HL‐1)': [53], 'frequently': [54], 'used': [55], 'for': [56], 'studying': [57], 'skeletal': [58], 'cells.': [59], 'Hoechst': [60], 'DNA,': [61, 102, 131], 'Lowry': [62], 'protein,': [63, 103, 132], 'proteoglycan': [64], '(PG),': [65], 'lactate': [66], 'dehydrogenase': [67], '(LDH),': [68], 'alkaline': [70], 'phosphatase': [71], '(ALP)': [72], 'activity': [73, 106], 'calcium': [75], 'phosphate': [77], 'mineral': [78, 235, 258], 'deposition': [79, 259], 'the': [81, 120, 231, 266, 357, 370], 'matrix': [83], 'measured.': [85], 'In': [86, 179, 251], 'preconfluent': [87, 202], 'DATP5,': [91, 205], 'physiological': [92, 276], 'levels': [93, 238, 289], '(0.10–10': [99], 'nM)': [100, 226], 'increased': [101, 143, 150, 257], 'LDH': [105, 127], 'significantly': [107], 'more': [108, 246], 'than': [109], 'did': [110], '(0.01–1.0': [115], 'nM).': [116], 'However,': [117], 'HL‐1,': [119], 'reverse': [121], 'was': [122], 'true.': [123], 'Determining': [124], 'ratios': [125], 'PG': [129, 352], 'each': [134], 'other,': [135], 'revealed': [136], 'that': [137, 310], 'specifically': [142], 'PG,': [144], 'whereas': [145], 'LDH.': [151], 'Post‐confluent': [152], 'cells': [153, 203], 'generally': [155], 'less': [156], 'responsive,': [157], 'especially': [158], '.': [164], 'The': [165, 221, 322], 'positive': [166], 'anabolic': [167, 324], 'required': [174, 262], 'GP‐fluid‐like': [176], 'medium.': [178], 'contrast,': [180, 252], 'most': [188], 'apparent': [189], 'medium,': [192], 'but': [193, 265], 'still': [195], 'significant': [196], 'media.': [199], 'Administered': [200], 'caused': [210, 227, 244], 'rapid,': [211], 'powerful,': [212], 'inhibition': [214, 229], 'Ca': [216, 299, 317], '2+': [217, 300, 318], 'Pi': [219], 'deposition.': [220], 'lowest': [222], 'level': [223], 'tested': [224], '(0.01': [225], '>70%': [228], 'during': [230], 'initial': [232], 'stages': [233], 'deposition;': [236], 'higher': [237], 'progressively': [245], 'profound': [247], 'persistent': [249], 'reductions.': [250], '20–50%;': [260], 'it': [261, 293], '>1': [263], 'week,': [264], 'specific,': [269], 'persistent,': [270], 'largely': [272], 'dosage‐independent.': [273], 'From': [274], 'perspective,': [277], 'these': [278], 'can': [280], 'be': [281], 'explained': [282], 'as': [283], 'follows:': [284], 'rise': [290], 'hypocalcemia;': [292], 'stimulates': [294], 'gut': [295], 'absorption': [296], 'releases': [298], 'from': [301], 'bone': [302, 341], 'correct': [304], 'this': [305], 'deficiency.': [306], 'We': [307], 'now': [308], 'show': [309], 'also': [315, 362], 'conserves': [316], 'by': [319], 'inhibiting': [320], 'mineralization.': [321], 'slow': [323], 'are': [331], 'consistent': [332], 'with': [333], 'its': [334], 'production': [335], 'under': [336], 'eucalcemic': [337], 'conditions': [338], 'which': [339, 345], 'enable': [340], 'formation.': [342], 'These': [343], 'findings,': [344], 'implicate': [346], 'serum‐binding': [347], 'proteins': [348], 'accumulation': [350], 'modulating': [354], 'accessibility': [355], 'metabolites': [358], 'chondrocytes,': [361], 'help': [363], 'explain': [364], 'some': [365], 'discrepancies': [366], 'previously': [367], 'reported': [368], 'literature.': [371], 'J.': [372], 'Cell.': [373], 'Biochem.': [374], '98:': [375], '309–334,': [376], '2006.': [377], '©': [378], '2006': [379], 'Wiley‐Liss,': [380], 'Inc.': [381]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2000670596', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2025-01-16T17:57:32.954144', 'created_date': '2016-06-24'}