Title: Direct Preparation of Nitriles from Carboxylic Acids in Continuous Flow
Abstract: A continuous-flow protocol for the preparation of organic nitriles from carboxylic acids has been developed. The method is based on the acid-nitrile exchange reaction with acetonitrile, used as the solvent, and takes place without any catalyst or additives under the high-temperature/high-pressure conditions employed. At 350 °C and 65 bar, where acetonitrile is in its supercritical state, the transformation of benzoic acid to benzonitrile requires 25 min. The protocol has been tested for a variety of nitriles, including aromatic and aliphatic substrates.
Publication Year: 2013
Publication Date: 2013-10-08
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 45
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot