Publication Information

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1067, 1114, 1158, 1187, 1236, 1312, 1372, 1416, 1430, 1475, 1502, 1565, 1585, 1758, 1860, 1870, 1877, 1908, 1923, 1946, 1983, 1986, 2028, 2042, 2049, 2066, 2210, 2606, 2640, 2665, 2713, 2716, 2748, 3186, 3196, 3238, 3250, 3304, 3369, 3403, 3447, 3455, 3471, 3532, 3673, 3820, 3887, 3915, 3920, 3943], 'functions': [19, 282, 3496], 'through': [20, 189, 283, 452, 1770, 3547, 3707], 'many': [21, 284], 'transcription': [22, 260, 285, 523, 662, 732, 1608, 1816, 1871, 1891, 1914, 3245, 3756, 3787, 4031], 'factors,': [23, 286, 1609, 1892], 'the': [24, 71, 80, 116, 127, 134, 158, 181, 208, 245, 287, 334, 343, 379, 390, 397, 421, 444, 471, 508, 558, 587, 594, 604, 609, 769, 788, 794, 803, 835, 1040, 1131, 1136, 1322, 1332, 1367, 1480, 1515, 1575, 1774, 1815, 1856, 1901, 1910, 1928, 1952, 1988, 1994, 2006, 2059, 2120, 2141, 2184, 2189, 2213, 2227, 2231, 2368, 2377, 2387, 2483, 2490, 2528, 2533, 2538, 2547, 2553, 2618, 2633, 2677, 2712, 2722, 2726, 2742, 2772, 2777, 2806, 2811, 2837, 2863, 2867, 2870, 2907, 2988, 3022, 3113, 3122, 3144, 3160, 3170, 3215, 3226, 3229, 3232, 3237, 3290, 3301, 3311, 3316, 3366, 3398, 3405, 3414, 3421, 3424, 3431, 3438, 3443, 3452, 3493, 3498, 3526, 3529, 3538, 3543, 3559, 3564, 3672, 3686, 3697, 3701, 3738, 3755, 3778, 3786, 3800, 3804, 3811, 3838, 3857, 3909, 3934, 4039, 4074, 4089, 4133, 4144, 4150, 4170, 4194, 4211, 4230, 4293], 'partners': [26, 289, 3923], 'identified': [27, 49, 290, 312, 1979, 3873], 'to': [28, 32, 291, 295, 532, 582, 586, 779, 811, 1034, 1127, 1171, 1182, 1318, 1485, 1514, 1567, 1571, 1574, 1588, 1595, 1868, 1921, 1927, 1961, 2003, 2194, 2700, 2708, 2751, 3045, 3112, 3339, 3384, 3450, 3508, 3669, 3713, 3724, 3799, 3814, 3825, 3845, 3930, 4107, 4140, 4200, 4209], 'date': [29, 292], 'are': [30, 293, 1586, 1916, 4063, 4109, 4173, 4187], 'unlikely': [31, 294], 'account': [33, 296, 4080], 'for': [34, 170, 180, 297, 433, 443, 549, 891, 1076, 2196, 2207, 2622, 2730, 2747, 3089, 3118, 3289, 3307, 3430, 3467, 3908, 3957, 4081, 4143, 4298], 'all': [35, 298, 1854], 'its': [37, 149, 300, 412, 832, 1053, 1057, 1061, 1593, 1771, 1958, 3846], 'biologic': [38, 301], 'actions.': [39, 302], 'orphan': [41, 304, 1970], 'nuclear': [42, 175, 217, 224, 305, 438, 480, 487, 562, 678, 687, 691, 748, 757, 761, 837, 1601, 1775, 1818, 1822, 1971, 2040, 2208, 3324, 3345, 3391, 3458, 3553, 3882, 3921, 3935, 3939], 'receptor': [43, 45, 218, 228, 306, 308, 481, 491, 679, 695, 749, 765, 1607, 1776, 1974, 2041, 3325, 3367, 3459, 3569, 3883, 3922, 3936, 3940, 3968], 'estrogen-related': [44, 307, 651, 721, 1973], 'α': [46, 309, 1975, 3969], '(ERRα)': [47, 310], 'was': [48, 66, 311, 329, 814, 1978, 2001, 2331, 2361, 2397, 2494, 2505, 2517, 2859, 2882, 2985, 3047, 3110, 3202, 3448, 4138], 'in': [50, 69, 83, 104, 244, 313, 332, 346, 367, 507, 537, 555, 565, 593, 608, 799, 823, 893, 1052, 1070, 1089, 1117, 1135, 1162, 1169, 1190, 1239, 1316, 1329, 1476, 1488, 1503, 1508, 1535, 1612, 1768, 1904, 1909, 1943, 2020, 2051, 2080, 2104, 2124, 2230, 2552, 2605, 3021, 3026, 3054, 3169, 3205, 3257, 3265, 3293, 3389, 3441, 3567, 3683, 3785, 3822, 3880, 4065, 4104, 4115, 4203], 'yeast': [52, 315, 1944], 'two-hybrid': [53, 316, 1934, 3191], 'screen': [54, 317, 1935], 'cardiac': [57, 89, 107, 320, 352, 370, 1505, 2264, 3173], 'cDNA': [58, 321, 1941, 2381, 2909], 'library': [59, 322, 1942], 'novel': [62, 237, 325, 500, 808, 1982, 2031, 2048, 3322], 'PGC-1α-binding': [63, 326], 'protein.': [64, 327, 1985], 'ERRα': [65, 94, 102, 132, 144, 185, 233, 328, 357, 365, 395, 407, 448, 496, 1992, 2015, 2026, 2310, 2380, 2396, 2958, 3181, 3198, 3221, 3233, 3253, 3401, 3415, 3425, 3709, 3849, 3913, 4077, 4090, 4116, 4153, 4177], 'implicated': [67, 330, 2011], 'previously': [68, 331, 2012, 3003, 3383], 'regulating': [70, 333, 3266, 4299], 'gene': [72, 129, 335, 392, 599, 1188, 1237, 1763, 2010, 2186, 2557], 'encoding': [73, 336, 1520, 2382, 2704], 'medium-chain': [74, 337, 647, 717, 1526], 'acyl-CoA': [75, 338, 648, 718, 1527], 'dehydrogenase': [76, 339, 1528], '(MCAD),': [77, 340, 1529], 'which': [78, 341, 535, 1895, 3442, 3548, 3708, 4046, 4054], 'catalyzes': [79, 342], 'initial': [81, 344], 'step': [82, 345], 'mitochondrial': [84, 248, 347, 511, 566, 902, 904, 1128, 1437, 1481, 1489, 1536, 1579, 1760, 1811, 1963, 3283, 3295], 'fatty': [85, 348, 643, 713, 905], 'acid': [86, 163, 349, 426, 644, 714, 906, 4196], 'oxidation.': [87, 350], 'perinatal': [90, 353], 'expression': [91, 354, 559, 600, 1055, 1115, 1159, 1189, 1238, 1500, 1764, 2203, 2583, 2813, 3276], 'pattern': [92, 355], 'paralleled': [95, 358], 'that': [96, 143, 157, 214, 359, 406, 420, 477, 1173, 1311, 1364, 1429, 1472, 1498, 1564, 2025, 2058, 3159, 3303, 3354, 3397, 3423, 3492, 3504, 3528, 3737, 3842, 4069, 4098, 4292], 'and': [99, 133, 198, 226, 234, 251, 362, 396, 461, 489, 497, 514, 544, 768, 793, 828, 909, 1030, 1042, 1060, 1092, 1167, 1232, 1241, 1441, 1491, 1507, 1530, 1598, 1614, 1821, 1993, 2019, 2083, 2089, 2093, 2101, 2234, 2238, 2244, 2391, 2627, 2635, 2645, 2680, 2736, 2763, 2810, 2827, 2880, 2915, 2924, 2937, 2959, 2976, 3083, 3099, 3121, 3133, 3135, 3174, 3199, 3222, 3254, 3274, 3282, 3503, 3535, 3571, 3690, 3850, 3869, 3965, 4042, 4052, 4078, 4178], 'MCAD.': [100, 363], 'Adenoviral-mediated': [101, 364], 'overexpression': [103, 366, 1473], 'primary': [105, 368, 1504, 3499], 'neonatal': [106, 369], 'mycoytes': [108, 371], 'induced': [109, 372, 1161], 'endogenous': [110, 373], 'MCAD': [111, 128, 374, 391, 2007, 2427, 2984, 3312], 'expression.': [112, 375], 'Furthermore,': [113, 376, 1360, 3829], 'enhanced': [115, 378, 1987], 'transactivation': [117, 380], 'reporter': [119, 382, 2540], 'plasmids': [120, 383, 2172, 2429], 'containing': [121, 384, 2376, 2479], 'an': [122, 385, 1486, 1919, 1937, 2014, 2324, 2673, 3351, 3410, 3464, 3715, 3746, 3750, 3826], 'estrogen': [123, 227, 386, 490, 694, 764, 2485], 'response': [124, 387, 680, 750, 1044, 1170, 1317, 1813, 2549, 4227], 'element': [125, 388, 2487, 2550], 'or': [126, 389, 1082, 2212, 2309, 2688, 2759, 2966, 4112], 'promoter': [130, 393, 661, 731, 2536, 2558], 'by': [131, 394, 540, 557, 1063, 1592, 1889, 1907, 2140, 2188, 2313, 2333, 2338, 2363, 2372, 2497, 2519, 2609, 2670, 2741, 2767, 2861, 2933, 2971, 3127, 3140, 3271, 3300, 3362, 3525, 3685, 3795, 3807, 3848, 4149], 'related': [135, 398, 581, 1995, 3929], 'isoform': [136, 399, 1996], 'ERRγ.': [137, 400, 1997, 3851, 4179], 'In': [138, 401, 1229, 1899, 2053, 2917, 3030], 'vitro': [139, 402, 1613, 2021, 2996, 3206], 'binding': [140, 205, 403, 468, 671, 675, 741, 745, 2022, 2063, 3058, 3105, 3207, 3210, 3217, 3234, 3247, 3318, 3326, 3359, 3390, 3416, 3572, 3680, 3740, 3805, 3878, 3952, 4084, 4106, 4212], 'experiments': [141, 404, 2113], 'demonstrated': [142, 405, 1412, 1428, 2024, 3396, 3524, 3736], 'interacts': [145, 408, 4026], 'with': [146, 173, 409, 436, 1120, 1597, 1966, 2037, 2177, 2304, 2902, 3049, 3103, 3197, 3243, 3344, 3402, 3420, 3433, 3456, 3470, 3521, 3533, 3552, 3734, 3854, 3886, 3914, 3917, 3942, 4027, 4085, 4095, 4191, 4214], 'via': [148, 411, 831, 1417, 2029, 4035], 'activation': [150, 413, 1365, 1414, 1517, 1772, 3309], 'function-2': [151, 414], 'homology': [152, 415, 4094], 'region.': [153, 416], 'Mutagenesis': [154, 417, 2614], 'studies': [155, 418, 885, 1308, 1426, 1562, 1617, 2023, 3314, 3395, 3556, 3732, 4220], 'revealed': [156, 419, 887, 3320], 'LXXLL': [159, 422, 3331, 3373, 3411, 3541, 3661, 3702, 3717, 3783, 4040], 'motif': [160, 192, 423, 455, 3327, 3349, 3412, 3445, 3495, 3546, 3748, 3784, 3802, 3813, 3818, 3841, 3859], 'at': [161, 193, 424, 456, 1766, 2098, 2226, 2676, 2684, 2756, 3092], 'amino': [162, 194, 425, 457, 667, 737, 2383, 4195], 'position': [164, 427], '142–146': [165, 428], '(L2),': [168, 431], 'necessary': [169, 432, 3306], 'interactions': [172, 435, 3343, 3520], 'other': [174, 216, 437, 479, 2038, 3244, 3518, 3918, 4070], 'receptors,': [176, 439, 1602, 2209, 3554, 3961], 'is': [177, 211, 440, 474, 529, 553, 1037, 1068, 1086, 1160, 1314, 1886, 2544, 3240, 3269, 3297, 3305, 3418, 3428, 3437, 3506, 3514, 3676, 3924, 3927], 'not': [178, 441, 617, 1853, 3721, 3862, 3871, 3945, 4188], 'required': [179, 442, 3429, 3537], 'PGC-1α·ERRα': [182, 209, 445, 472, 1999, 3161, 3216, 3264, 3317], 'interaction.': [183, 446, 3230], 'Rather,': [184, 447], 'binds': [186, 259, 449, 522, 2027], 'primarily': [188, 451, 1591, 3710], 'Leu-rich': [191, 454, 3348, 3565], 'acids': [195, 458, 2384], '209–213': [196, 459], '(Leu-3)': [197, 460], 'utilizes': [199, 462], 'additional': [200, 463], 'LXXLL-containing': [201, 464], 'domains': [202, 465, 2035, 3211, 3662], 'accessory': [204, 467, 3465], 'sites.': [206, 469, 3248], 'Thus,': [207, 470, 569], 'interaction': [210, 473, 2998, 3162, 3194, 3399, 3432, 3453, 3469, 3502, 3530, 3885, 3911], 'distinct': [212, 475, 2062, 3515, 3658, 4135, 4175], 'from': [213, 476, 1039, 1123, 2268, 2323, 2352, 2367, 2508, 2771, 2783, 2818, 2866, 2906, 3516, 3754], 'partners,': [220, 483], 'including': [221, 484, 901, 3962], 'PPARα,': [222, 485, 2914], 'hepatocyte': [223, 486, 690, 760], 'factor-4α,': [225, 488], 'α.': [229, 492, 696, 766], 'These': [230, 493, 2044, 4180], 'results': [231, 494, 1422, 2045, 2056, 3490], 'identify': [232, 495, 1922, 2046], 'ERRγ': [235, 498, 3255, 4079], 'interacting': [239, 502, 1924, 1984, 3187], 'proteins,': [240, 503], 'implicate': [241, 504], 'ERR': [242, 505, 3279, 4066, 4296], 'isoforms': [243, 506, 3201, 3256, 4297], 'regulation': [246, 509, 571, 596, 795, 3171], 'metabolism,': [250, 513], 'suggest': [252, 515, 1563, 2057, 4182, 4291], 'potential': [254, 517, 3372], 'mechanism': [255, 518, 2069, 3513], 'whereby': [256, 519, 2070], 'selectively': [258, 521], 'factor': [261, 524, 1872, 3246, 3758, 3789, 4033], 'partners.': [262, 525, 1873, 2043], 'Cellular': [526], 'production': [528, 552, 1965], 'tightly': [530], 'linked': [531, 1570], 'metabolic': [533, 598, 899, 1438], 'demand,': [534], 'is,': [536], 'turn,': [538], 'dictated': [539], 'diverse': [541, 579, 2081], 'developmental,': [542], 'physiologic,': [543], 'environmental': [545], 'conditions.': [546], 'capacity': [548, 1960], 'ATP': [551, 1077], 'controlled,': [554], 'part,': [556, 1769], 'levels': [560], 'genes': [563, 797, 1519], 'involved': [564, 592, 607, 798, 1903, 3168, 4103, 4190], 'oxidative': [567, 1074], 'tight': [570], 'metabolism': [575, 615, 1075, 1864, 1885, 3268], 'necessitates': [576], 'transduction': [577], 'signals': [580], 'demands': [585, 1573], 'nucleus.': [588], 'numerous': [590, 1600, 3555], 'factors': [591, 1817, 1915], 'have': [601, 616, 783, 886, 1309, 1362, 1427, 1470, 1865, 2430, 2647, 3000, 3336, 3557, 3954, 4221], 'identified,': [603, 813], 'precise': [605], 'pathways': [606], 'physiologic': [610, 1572, 2084], 'control': [611, 1577, 2195], 'delineated.': [619], 'recent': [621, 1424, 1561, 3729], 'discovery': [622], '(PGC-1α),': [626], '1The': [627, 697], 'abbreviations': [628, 698], 'used': [629, 699], 'are:': [630, 700], 'PGC-1α,': [631, 701, 802, 3223, 3281, 3522], 'coactivator-1α;': [633, 703], 'BAT,': [634, 704, 1166], 'brown': [635, 705, 824], 'adipose': [636, 706, 825], 'tissue;': [637, 707], 'PPAR,': [638, 708], 'peroxisome': [639, 709], 'proliferator-activated': [640, 710], 'receptor;': [641, 652, 688, 711, 722, 758], 'FAO,': [642, 712], 'oxidation;': [645, 715], 'MCAD,': [646, 716, 2912], 'dehydrogenase;': [649, 719], 'ERR,': [650, 720], 'GFP,': [653, 723], 'green': [654, 724], 'fluorescent': [655, 725], 'protein;': [656, 726], 'COUP-TF,': [657, 727], 'chicken': [658, 728], 'ovalbumin': [659, 729], 'upstream': [660, 730, 2488, 2531, 3695, 3836], 'factor;': [663, 733], 'GST,': [664, 734], 'glutathioneS-transferase;': [665, 735], 'aa,': [666, 736], 'acid;': [668, 738], 'LBD,': [669, 739], 'ligand': [670, 740, 4105], 'domain;': [672, 676, 742, 746], 'DBD,': [673, 743], 'DNA': [674, 744, 4226], 'NRRE,': [677, 747], 'element;': [681, 751], 'MAPK,': [682, 752], 'mitogen-activated': [683, 753, 1324], 'protein': [684, 754, 1032, 1047, 1313, 1325, 1333, 2348, 3043, 3053], 'kinase;': [685, 755], 'NR,': [686, 756], 'HNF-4α,': [689, 759], 'factor-4α;': [692, 762], 'ERα,': [693, 763, 3963], 'PGC-1β,': [767], 'PGC-1-related': [770, 1031], 'protein,': [771], 'family': [773, 810], 'inducible': [775], 'coactivators': [777, 1051], 'responsive': [778, 2486], 'selective': [780], 'physiological': [781, 1065], 'stimuli,': [782], 'provided': [784, 2371, 2496, 2970], 'new': [785], 'insights': [786], 'into': [787, 2386, 2527, 2696, 2721, 2776, 2869, 3356], 'link': [789], 'between': [790, 4038, 4176], 'extracellular': [791], 'events': [792], 'first': [804, 3439, 3698], 'member': [805], 'this': [807, 2071, 3436, 3670, 3725], 'be': [812, 1035, 1589, 1897, 3714, 4141], 'initially': [815], 'key': [819], 'thermogenesis': [822], 'tissue': [826], '(BAT)': [827, 1084], 'skeletal': [829, 1080, 1164, 1242, 3175], 'muscle': [830, 3176], 'coactivation': [833, 1373], 'adipose-enriched': [836], 'receptor,': [838, 1972], '(1Puigserver': [840, 1094, 1192, 1618], 'P.,': [841, 1095, 1193, 1619, 1739], 'Wu,': [842, 972, 1005, 1096, 1194, 1340, 1620, 1683, 1740], 'Z.': [843, 858, 912, 973, 1006, 1097, 1195, 1341, 1444, 1621, 1636, 1684, 1826], 'Park': [844, 1098, 1196, 1622], 'C.W.': [845, 1099, 1197, 1623], 'Graves': [846, 1100, 1198, 1624], 'R.': [847, 1101, 1199, 1625, 2159, 2286, 2444, 4011], 'Wright': [848, 1102, 1200, 1626], 'M.': [849, 1103, 1201, 1264, 1268, 1270, 1292, 1296, 1627, 2562, 2819, 3988, 4124, 4161, 4277], 'Spiegelman': [850, 877, 931, 984, 1019, 1104, 1202, 1352, 1440, 1463, 1628, 1655, 1697, 1845], 'B.M.': [851, 878, 932, 985, 1020, 1105, 1203, 1353, 1464, 1629, 1656, 1698, 1728, 1846], 'Cell.': [852, 879, 933, 945, 1106, 1204, 1355, 1465, 1630, 1657, 1669, 1785, 1847, 2165, 2292, 2450, 2597, 2657, 2798, 2851, 3011, 3591, 3649, 4270], '1998;': [853, 1107, 1205, 1631, 2260, 2421, 2895, 3625, 4021, 4272], '92:': [854, 1108, 1206, 1632], '829-839Google': [855, 1109, 1207, 1633], 'Scholar,': [856, 937, 950, 969, 996, 1208, 1284, 1634, 1661, 1674, 1703, 1720, 1737, 1790, 2455, 3596, 3984, 3999, 4248, 4262, 4275], '2Wu': [857, 1635], 'Puigserver': [859, 913, 976, 999, 1445, 1637, 1677, 1723, 1827], 'P.': [860, 914, 977, 1000, 1335, 1446, 1638, 1678, 1724, 1828, 2566, 3990], 'Andersson': [861, 915, 1447, 1639, 1829], 'U.': [862, 916, 990, 1405, 1448, 1640, 1714, 1830, 2418, 2470, 3482, 3898], 'Zhang': [863, 917, 1215, 1344, 1449, 1641, 1831], 'C.': [864, 918, 1450, 1642, 1832, 2373, 2572, 4122, 4159], 'Adelmant': [865, 919, 978, 1009, 1451, 1643, 1687, 1833], 'G.': [866, 920, 979, 1002, 1010, 1452, 1644, 1680, 1688, 1834], 'Mootha': [867, 921, 1348, 1453, 1645, 1835], 'V.': [868, 922, 1454, 1646, 1836, 2570, 2972], 'Troy': [869, 923, 1455, 1647, 1837], 'A.': [870, 924, 956, 992, 1144, 1214, 1250, 1400, 1407, 1456, 1545, 1648, 1709, 1716, 1796, 1838, 2420, 2472, 3477, 3484, 3608, 3893, 3900], 'Cinti': [871, 925, 1457, 1649, 1839], 'S.': [872, 926, 991, 1266, 1347, 1406, 1458, 1650, 1715, 1840, 2153, 2280, 2404, 2419, 2438, 2459, 2471, 2498, 2825, 3483, 3604, 3899, 4005, 4118, 4155], 'Lowell': [873, 927, 1219, 1350, 1459, 1651, 1841], 'B.': [874, 928, 1460, 1652, 1842, 2413], 'Scarpulla': [875, 929, 1461, 1653, 1843], 'R.C.': [876, 930, 1462, 1654, 1844], '1999;': [880, 934, 1225, 1466, 1658, 1848, 3593, 3651], '98:': [881, 935, 994, 1409, 1467, 1659, 1718, 1849, 3486, 3902], '115-124Google': [882, 936, 1468, 1660, 1850], 'Scholar).': [883, 1025, 1110, 1157, 1228, 1306, 1359, 1390, 1558, 1754, 1809, 1851, 2170, 2297, 2476, 2602, 2662, 2803, 2856, 2898, 2955, 3016, 3488, 3628, 3775, 4024, 4131, 4168, 4288], 'Subsequent': [884], 'broader': [889], 'role': [890, 1875, 3288, 3388, 3462], 'variety': [895], 'processes': [900], 'biogenesis,': [903], 'oxidation': [907], '(FAO),': [908], 'gluconeogenesis': [910], '(2Wu': [911, 1443, 1825], '3Vega': [938, 1662], 'R.B.': [939, 975, 1663, 1779, 2591, 2651, 2792, 2845, 3005], 'Huss': [940, 1664, 1780, 2592, 2652, 2793, 2846, 3006], 'J.M.': [941, 1665, 1781, 2593, 2653, 2794, 2847, 2944, 3007], 'Kelly': [942, 961, 982, 1149, 1255, 1297, 1382, 1550, 1666, 1782, 1801, 2162, 2255, 2289, 2447, 2464, 2594, 2654, 2795, 2848, 2890, 2947, 3008], 'D.P.': [943, 962, 983, 1150, 1256, 1298, 1383, 1551, 1667, 1730, 1783, 1802, 2163, 2256, 2290, 2448, 2465, 2595, 2655, 2796, 2849, 2891, 2948, 3009, 3589, 3647], 'Mol.': [944, 1354, 1668, 1784, 2164, 2291, 2449, 2596, 2656, 2797, 2850, 3010, 3590, 3648, 3770, 3979, 4243, 4269], 'Biol.': [946, 1385, 1670, 1732, 1749, 1786, 2166, 2258, 2293, 2451, 2574, 2598, 2658, 2799, 2852, 2893, 2950, 3012, 3592, 3650, 3771, 3980, 4126, 4163, 4271, 4283], '2000;': [947, 966, 1154, 1260, 1281, 1555, 1671, 1734, 1787, 1806, 2599, 2659, 2800, 2853, 3013, 3772, 3981], '20:': [948, 1672, 1788, 2600, 2660, 2801, 2854, 3014], '1868-1876Google': [949, 1673, 1789, 2601, 2661, 2802, 2855, 3015], '4Lehman': [951, 1791], 'J.J.': [952, 981, 1140, 1246, 1541, 1792], 'Barger': [953, 1141, 1247, 1542, 1793, 2156, 2283, 2441], 'P.M.': [954, 1142, 1248, 1377, 1543, 1794, 2157, 2284, 2442], 'Kovacs': [955, 1143, 1249, 1544, 1795], 'Saffitz': [957, 1145, 1251, 1546, 1797], 'J.E.': [958, 1146, 1252, 1547, 1798, 4007], 'Medeiros': [959, 1147, 1253, 1548, 1799], 'D.': [960, 1148, 1254, 1396, 1398, 1549, 1705, 1707, 1800, 2509, 2564, 2784, 3473, 3475, 3587, 3645, 3889, 3891, 3994, 4120, 4157], 'J.': [963, 1008, 1012, 1151, 1257, 1302, 1337, 1384, 1552, 1686, 1690, 1731, 1748, 1803, 2252, 2257, 2409, 2568, 2573, 2828, 2887, 2892, 2949, 3610, 3612, 3767, 3976, 4125, 4162, 4282], 'Clin.': [964, 1152, 1258, 1553, 1804], 'Invest.': [965, 1153, 1259, 1554, 1805], '106:': [967, 1155, 1261, 1556, 1807], '847-856Google': [968, 1156, 1262, 1557, 1808], '5Michael': [970], 'L.F.,': [971], 'Cheatham': [974], 'Lehman': [980], 'Proc.': [986, 1401, 1710, 2414, 2466, 3478, 3894], 'Natl.': [987, 1402, 1711, 2415, 2467, 3479, 3895], 'Acad.': [988, 1403, 1712, 2416, 2468, 3480, 3896], 'Sci.': [989, 1404, 1713, 2417, 2469, 3481, 3897], '2001;': [993, 1022, 1356, 1387, 1408, 1700, 1717, 2952, 3485, 3901, 4128, 4165, 4245], '3820-3825Google': [995], '6Yoon': [997, 1675], 'J.C.': [998, 1343, 1676], 'Chen': [1001, 1295, 1679], 'Donovan': [1003, 1681], 'J.,': [1004, 1339, 1682], 'Rhee': [1007, 1336, 1685], 'Stafford': [1011, 1689], 'Kahn': [1013, 1691], 'C.R.': [1014, 1692], 'Granner': [1015, 1693], 'D.K.': [1016, 1694], 'Newgard': [1017, 1695], 'C.B.': [1018, 1696], 'Nature.': [1021, 1699, 3995, 4020], '413:': [1023, 1701], '131-138Google': [1024, 1702], 'function': [1027], 'PGC-1β': [1029], 'remain': [1033], 'defined.PGC-1α': [1036], 'unique': [1038, 3241, 3910], 'p160': [1041, 3950], 'p300/cAMP': [1043], 'element-binding': [1045], 'protein-binding': [1046], 'classes': [1048, 3659], 'tissue-restricted': [1054], 'pattern,': [1056], 'developmental': [1058, 3275], 'regulation,': [1059], 'inducibility': [1062], 'specific': [1064], 'stimuli.': [1066], 'enriched': [1069], 'tissues': [1071], 'reliant': [1072], 'on': [1073, 1125, 1611, 1759, 1861, 1951, 2546, 3219, 3328, 4093, 4229], 'generation': [1078], '(heart,': [1079], 'muscle)': [1081], 'heat': [1083], 'but': [1085, 3926], 'also': [1087, 1917, 2320, 4174], 'expressed': [1088], 'liver,': [1090], 'brain,': [1091], 'kidney': [1093], 'Immediately': [1111], 'after': [1112], 'birth,': [1113], 'increases': [1116], 'heart': [1118, 1168, 1240, 1940, 1955], 'coincident': [1119], 'shift': [1122], 'reliance': [1124], 'glycolysis': [1126], 'FAO': [1129, 1522, 1761, 3284, 3296], 'chief': [1132], 'source': [1134], 'adult': [1137, 1163, 1938, 1953], 'myocardium': [1138], '(4Lehman': [1139, 1245, 1540], 'muscle,': [1165, 1243], 'stimuli': [1172, 1569], 'increase': [1174, 1487, 1534], 'demands.': [1176, 1968], 'For': [1177, 2112, 2199], 'example,': [1178], 'cold': [1179, 3104], 'exposure': [1180], 'leads': [1181, 1513], 'rapid': [1184], 'induction': [1185], 'BAT': [1191], '7Boss': [1209], 'O.': [1210, 1218], 'Bachman': [1211], 'E.': [1212], 'Vidal-Puig': [1213], 'C.-Y.': [1216, 1345], 'Peroni': [1217], 'B.B.': [1220, 1351], 'Biochem.': [1221, 1277, 3769, 3978], 'Biophys.': [1222, 1278], 'Res.': [1223, 1279], 'Commun.': [1224, 1280], '261:': [1226], '870-876Google': [1227], 'addition,': [1230, 1900, 2054, 2918], 'fasting': [1231], 'short-term': [1233], 'exercise': [1234], 'induces': [1235], 'respectively': [1244], 'Scholar,8Goto': [1263], 'Terada': [1265], 'Kato': [1267], 'Katoh': [1269], 'Yokozeki': [1271], 'T.': [1272, 1276, 2457, 2461], 'Tabata': [1273], 'I.': [1274, 1722], 'Shimokawa': [1275], '274:': [1282], '350-354Google': [1283], '9Baar': [1285], 'K.': [1286], 'Wende': [1287], 'A.R.': [1288], 'Jones': [1289], 'T.E.': [1290], 'Marison': [1291], 'Nolte': [1293, 3613, 4002], 'L.A.': [1294, 3581, 3639], 'Holloszy': [1299], 'J.O.': [1300], 'FASEB': [1301], '2002;': [1303, 1751], '(in': [1304], 'press)Google': [1305], 'Recent': [1307, 4289], 'shown': [1310, 1363, 1471, 1497, 2002, 3338, 3382, 4139], 'phosphorylated': [1315], 'cytokine': [1319], 'stimulation': [1320], 'p38': [1323, 1368], 'kinase': [1326, 2535], 'pathway': [1327, 1369], 'resulting': [1328], 'stabilization': [1330], '(10Puigserver': [1334], 'Lin': [1338], 'Yoon': [1342], 'Kraquss': [1346], 'V.K.': [1349], '8:': [1357], '971-982Google': [1358], 'we': [1361, 1931], 'enhances': [1370], 'ligand-dependent': [1371], 'PPARα': [1375, 1777], '(11Barger': [1376], 'Browning': [1378], 'A.C.': [1379], 'Garner': [1380], 'A.N.': [1381], 'Chem.': [1386, 1733, 1750, 2259, 2575, 2894, 2951, 4127, 4164, 4284], '276:': [1388, 2953, 4129, 4166], '44495-44501Google': [1389], 'Finally,': [1391, 3852], 'Knutti': [1392], 'et': [1393, 3630], 'al.': [1394, 3631], '(12Knutti': [1395, 3472, 3888], 'Kressler': [1397, 1706, 3474, 3890], 'Kralli': [1399, 1708, 3476, 3892], '9713-9718Google': [1410, 1719, 3487, 3903], 'Scholar)': [1411, 1469, 3654, 3904], 'p38-mediated': [1413], 'release': [1418], 'repressor.The': [1421], 'gain-of-function': [1425], 'serves': [1431, 1566], 'global': [1434], 'capacity.': [1439], 'co-workers': [1442], 'myogenic': [1477], 'cells': [1478, 2095, 2117, 2235, 2301, 2342, 2353], 'activates': [1479], 'biogenic': [1482], 'program': [1483], 'leading': [1484], 'number': [1490, 3959, 4218], 'respiration': [1492], 'rates.': [1493], 'Our': [1494, 3393, 3489], 'laboratory': [1495], 'forced': [1499], 'myocytes': [1506, 2265], 'hearts': [1509], 'transgenic': [1511], 'mice': [1512], 'mitchondrial': [1521], 'enzymes,': [1523], 'such': [1524], 'triggers': [1531], 'robust': [1533], 'volume': [1538], 'density': [1539], 'Collectively,': [1559], 'these': [1560, 3855, 3866, 4061, 4185, 4207], 'transduce': [1568], 'functional': [1580, 3165], 'capacity.The': [1581], 'regulatory': [1582], 'effects': [1583, 1756, 1858, 4224], 'thought': [1587], 'mediated': [1590, 1888], 'ability': [1594], 'interact': [1596, 3551], 'coactivate': [1599], 'well': [1604], 'non-nuclear': [1606], 'based': [1610, 2545, 3663, 4092], 'cell': [1615, 2347], 'culture': [1616], '12Knutti': [1704], '13Tcherepanova': [1721], 'Norris': [1725, 3576, 3634], 'J.D.': [1726, 3577, 3635], 'Speigelman': [1727], 'McDonnell': [1729, 3588, 3646], '275:': [1735], '16302-16308Google': [1736], '14Delerive': [1738], 'Y.': [1741], 'Burris': [1742], 'T.P.': [1743], 'Chin': [1744, 4280], 'W.W.': [1745, 4281], 'Suen': [1746], 'C.S.': [1747], '277:': [1752], '3913-3917Google': [1753], 'enzyme': [1762, 3285], 'occur,': [1765], 'least': [1767], '(3Vega': [1778, 2590, 2650, 2791, 2844, 3004], 'biogenesis': [1812], 'involves': [1814, 3404], 'respiratory': [1819, 1823], 'factor-1': [1820], 'factor-2': [1824], 'However,': [1852, 3435, 3728, 3949], 'downstream': [1857, 2078], 'ascribed': [1867], 'particular': [1869, 4300], '“master”': [1880], 'likely': [1887], 'multiple': [1890, 2077, 3179], 'some': [1893], 'could': [1896, 3744], 'novel.': [1898], 'mechanisms': [1902], 'partner': [1905], 'selection': [1906], 'context': [1911], 'coexpressed': [1913], 'unknown.In': [1918], 'attempt': [1920], 'proteins': [1925, 3018, 3124, 3188, 3335, 3550], 'relevant': [1926], 'postnatal': [1929], 'heart,': [1930], 'performed': [1932, 2139, 2398, 2883, 2940, 2962, 3733], 'human': [1939, 2379, 2554, 2919], 'using': [1945, 2343, 2617, 2632, 2749, 2963, 2987, 3143, 3189, 3204], '“bait.”': [1948], 'We': [1949], 'focused': [1950], 'mammalian': [1954, 2202, 2582, 2728], 'because': [1956], 'extraordinary': [1959], 'match': [1962, 3863], 'high': [1967, 3876], '(ERRα;': [1976], 'NR3B1),': [1977], 'activities': [1990, 2246], 'complex': [2000, 3167, 3292], 'directly': [2004, 4189], 'activate': [2005, 2076], 'promoter,': [2008, 2193, 2493], 'target.': [2016], 'Functional': [2017], 'assays': [2018, 2999], 'set': [2032], 'leucine-rich': [2034], 'compared': [2036, 3242, 3916], 'target': [2050, 4301], 'heart.': [2052], 'our': [2055], 'utilization': [2060], 'interfaces': [2064], 'within': [2065, 3214, 3236, 3333, 3749, 3933, 4030, 4048, 4056, 4073], 'provides': [2067], 'one': [2068, 3378, 3808], 'versatile': [2072], 'may': [2074, 3843, 4198], 'differentially': [2075], 'effectors': [2079], 'contexts.EXPERIMENTAL': [2085], 'PROCEDURESMammalian': [2086], 'Cell': [2087], 'Culture': [2088], 'Transient': [2090, 2136], 'TransfectionsCV1,': [2091], '293,': [2092], 'HepG2': [2094, 2116], 'were': [2096, 2118, 2138, 2175, 2217, 2220, 2236, 2247, 2266, 2302, 2350, 2607, 2630, 2668, 2692, 2718, 2739, 2765, 2815, 2900, 2928, 2931, 2939, 2961, 3019, 3097, 3116, 3125, 3131, 3138, 3183, 3212], 'maintained': [2097], '37': [2099], '°C': [2100], '5%': [2102], 'CO2': [2103], "Dulbecco's": [2105], 'modified': [2106], "Eagle's": [2107], 'medium/10%': [2108], 'fetal': [2109, 2133], 'calf': [2110, 2134], 'serum.': [2111, 2135], 'requiring': [2114], 'estradiol,': [2115], 'plated': [2119], 'day': [2121], 'before': [2122], 'transfection': [2123, 2197, 2224], "Earle's": [2125], 'minimum': [2126], 'essential': [2127, 4142], 'medium': [2128], 'without': [2129], 'phenol': [2130], 'red/10%': [2131], 'stripped': [2132], 'transfections': [2137], 'calcium': [2142], 'phosphate': [2143], 'coprecipitation': [2144], 'method': [2145], 'described': [2147, 2250, 2274, 2400, 2432, 2588, 2649, 2745, 2790, 2842, 2885, 2942, 2991, 3002, 4222], '(15Disch': [2148, 2275, 2433], 'D.L.': [2149, 2276, 2434], 'Rader': [2150, 2277, 2435], 'T.A.': [2151, 2278, 2436], 'Cresci': [2152, 2279, 2437, 2458], 'Leone': [2154, 2281, 2439], 'T.C.': [2155, 2282, 2402, 2440], 'Vega': [2158, 2285, 2443], 'Wood': [2160, 2287, 2445], 'P.A.': [2161, 2288, 2446], '1996;': [2167, 2294, 2452, 4259, 4285], '16:': [2168, 2295, 2453], '4043-4051Google': [2169, 2296, 2454], 'Reporter': [2171], '(4': [2173], 'μg/ml)': [2174], 'cotransfected': [2176], 'Rous': [2178, 2190], 'sarcoma': [2179, 2191, 2808], 'virus-β-galactosidase': [2180], '(0.5': [2181], 'μg/ml),': [2182], 'expressing': [2183, 2306, 2395], 'β-galactosidase': [2185, 2245], 'driven': [2187, 2312], 'virus': [2192], 'efficiency.': [2198], 'cotransfection': [2200, 2731], 'experiments,': [2201], 'vectors': [2204, 2216, 2814], '(see': [2205], 'below)': [2206], 'constructs,': [2211], 'corresponding': [2214, 2773], 'empty': [2215], 'used.': [2218], 'Ligands': [2219], 'added': [2221, 3111], 'immediately': [2222, 3694], 'following': [2223, 2908], 'protocol': [2225], 'concentrations': [2228], 'indicated': [2229], 'figure': [2232], 'legends,': [2233], 'collected': [2237], 'assayed': [2239], '48': [2240], 'h': [2241, 2300, 2335, 2355, 3091], 'later.': [2242], 'Luciferase': [2243], 'measured': [2248], '(16Brandt': [2251, 2886], 'Djouadi': [2253, 2888], 'F.': [2254, 2889], '273:': [2261, 2896], '23786-23792Google': [2262, 2897], 'Scholar).Ventricular': [2263], 'prepared': [2267, 2351], '1-day-old': [2269], 'Harlan': [2270], 'Sprague-Dawley': [2271], 'rats': [2272], 'After': [2298], '24': [2299], 'infected': [2303], 'adenovirus': [2305, 2394], 'GFP': [2307, 2322], '(Ad-GFP)': [2308], '(Ad-ERRα)': [2311], 'cytomegalovirus': [2315, 2697], 'promoter.': [2316, 2326], 'latter': [2318], 'construct': [2319, 2375, 2775], 'expresses': [2321], 'independent': [2325, 3180], 'Infection': [2327], 'rate': [2328], '90–95%': [2330], 'achieved': [2332], '18': [2334], 'assessed': [2337], 'quantitation': [2339], 'GFP-expressing': [2341], 'fluorescence': [2344], 'microscopy.': [2345], 'Whole': [2346], 'extracts': [2349, 2930], '72': [2354], 'post-infection.': [2356], 'adenoviral': [2358], 'construct,': [2359], 'Ad-ERRα,': [2360], 'constructed': [2362, 2518], 'subcloning': [2364, 2768, 2862], 'aSalI/NotI': [2365], 'fragment': [2366, 2770, 2865], 'pBK-ERRα': [2369], '(generously': [2370], 'Teng)': [2374], 'full-length': [2378, 2735], '1–422': [2385], 'pAd-Track-cytomegalovirus': [2388], 'vector.': [2389], 'Recombination': [2390], 'propagation': [2392], '(17He': [2401], 'Zhou': [2403, 4119, 4156], 'da': [2405], 'Costa': [2406], 'L.T.,': [2407], 'Yu,': [2408], 'Kinzler': [2410], 'K.W.': [2411], 'Vogelstein': [2412], '95:': [2422], '2509-2514Google': [2423], 'Scholar).Plasmid': [2424], 'ConstructsReporter': [2425], 'PlasmidsThe': [2426, 2581], 'promoter-luciferase': [2428], '18Gulick': [2456], 'Caira': [2460], 'Moore': [2462, 2510], 'D.D.': [2463], '1994;': [2473], '91:': [2474], '11012-11016Google': [2475], 'Vit2P36.Luc,': [2478], 'two': [2480], 'copies': [2481], 'vitellogenin': [2484], 'prolactin': [2491], 'minimal': [2492], 'generously': [2495, 2969], 'Adler': [2499], '(Southern': [2500], 'Illinois': [2501], 'University).': [2502], '(UAS)3.TK.Luc': [2504], 'gift': [2507, 2782], '(Baylor': [2511, 2979], 'College': [2512, 2980], 'Medicine).': [2514], '(APOCIII)2.TK.Luc': [2516], 'ligation': [2520], 'annealed': [2522], 'oligonucleotides': [2523], '(sense': [2524], 'strand': [2525], '5′-GATCCTCATCTCCACTGGTCAGCAGGTGACCTTTGCCCAGCGCCCTGGGA-3′)': [2526], 'BamHI/BglII': [2529], 'site': [2530, 2724, 3417, 3466, 3500, 3675, 3681, 3806, 3879], 'thymidine': [2534], 'pGL2-TK.Luc': [2539], 'plasmid.': [2541], 'sequence': [2543, 3566], 'HNF-4': [2548, 3536], 'contained': [2551], 'apolipoprotein': [2555], 'CIII': [2556], '(19Ladias': [2559], 'J.A.A.': [2560], 'Hadzopoulou-Cladaras': [2561], 'Kardassis': [2563], 'Cardot': [2565], 'Cheng': [2567], 'Zannis': [2569], 'Cladaras': [2571], '1992;': [2576], '267:': [2577], '15849-15860Google': [2578], 'Scholar).Mammalian': [2579], 'Expression': [2580, 2834], 'vector': [2584, 2729, 2872], 'pcDNA3.1-Myc/His.PGC-1α': [2585], 'elsewhere': [2589, 2843], 'Site-directed': [2603], 'mutations': [2604, 2629], 'introduced': [2608], 'PCR-based': [2611], 'strategy': [2612], '(Quickchange': [2613], 'kit;': [2615], 'Stratagene)': [2616], 'Myc/His.PGC-1α': [2619], 'template': [2621], 'single-site': [2623], 'mutants.': [2624], 'double-': [2626], 'triple-site': [2628], 'made': [2631], 'single-': [2634], 'double-mutant': [2636], 'templates,': [2637], 'respectively.': [2638, 2983], 'deletion': [2641, 2666, 2737], 'series,': [2642], 'PGC338,': [2643], 'PGC285,': [2644], 'PGC120,': [2646], 'Additional': [2663], 'FLAG-tagged': [2664], 'constructs': [2667, 2717, 2738], 'generated': [2669, 2740, 2766, 2860], 'PCR': [2671, 2690, 2750], 'introducing': [2672], 'in-frame': [2674], 'BglII': [2675], 'start': [2678], 'codon': [2679, 2683, 2755], 'stop': [2682, 2754], '273,': [2685], '213,': [2686], '208,': [2687], '191.': [2689], 'fragments': [2691], 'then': [2693], 'subcloned': [2694], '(BglII/XhoI)': [2695], 'promoter-Tag1': [2698], '(Stratagene)': [2699], 'fuse': [2701], 'cassette': [2703], 'FLAG': [2706], 'epitope': [2707], '5′': [2709], 'end': [2710], 'sequence.': [2714], 'subsequently': [2719], 'cloned': [2720], 'NotI': [2723], 'pcDNA3.1': [2727, 2774], 'studies.': [2732], 'pcDNA3.1-FLAG-ERRα': [2734], 'same': [2743, 4171], 'procedure': [2744], 'above': [2746], 'introduce': [2752], '403,': [2757], '359,': [2758], '209.': [2760], 'Gal4-ERRα': [2762], 'Gal4-ERRα403': [2764], 'theBamHI': [2769], 'pCMX-Gal4': [2778], 'plasmid': [2779], '(a': [2780], 'kind': [2781, 2816], 'Moore).': [2785], 'Gal4-PPARα': [2787], 'pSG5-hemagglutinin-ERRγ,': [2805], 'pBK-Rous': [2807], 'virus-ERα,': [2809], 'pMT-HNF-4': [2812], 'gifts': [2817], 'Stallcup': [2820], '(University': [2821], 'Southern': [2823], 'California),': [2824], 'Adler,': [2826], 'Ladias': [2829], '(Harvard': [2830], 'Medical': [2831], 'School),': [2832], 'respectively.Bacterial': [2833], 'PlasmidsConstruction': [2835], 'pGex4T-': [2838], '3-PGC338': [2839], 'pGex4T-3-ERRα': [2858], 'BamHI': [2864], 'pcDNA3.1-ERRα': [2868], 'pGex4T-3': [2871], '(Amersham': [2873], 'Biosciences).Northern': [2874], 'Blot': [2875], 'AnalysisTotal': [2876], 'RNA': [2878], 'isolation': [2879], 'blotting': [2881], 'Blots': [2899], 'hybridized': [2901], 'radiolabeled': [2903], 'probes': [2904, 2927], 'derived': [2905, 3753], 'mouse': [2910], 'clones:': [2911], 'ERRγ,': [2913], 'PGC-1α.': [2916, 3329, 3434, 4086, 4215], 'ERRα,': [2920], 'rat': [2921], 'M-CPT': [2922], 'I,': [2923], 'universal': [2925], 'actin': [2926], 'used.ImmunoblottingProtein': [2929], 'resolved': [2932], 'SDS-PAGE': [2934, 3107], '(7.5%).': [2935], 'Transfer': [2936], 'detection': [2938], '(20Huss': [2943], 'Levy': [2945], 'F.H.': [2946], '27605-27612Google': [2954], 'Immunodetection': [2956], 'COUP-TF': [2960], 'polyclonal': [2964], 'anti-ERRα': [2965], 'anti-COUP-TF': [2967], 'antibodies': [2968], 'Giguere': [2973], '(McGill': [2974], 'University)': [2975], 'M.-J.': [2977], 'Tsai': [2978], 'Medicine),': [2982], 'detected': [2986], 'anti-MCAD': [2989], 'antibody': [2990], 'previously.GST': [2992], 'Pull': [2993], 'Down': [2994], 'AssaysIn': [2995], 'protein-protein': [2997], '35S-Labeled': [3017], 'synthesized': [3020], 'TNT': [3023], 'T7': [3024], 'quick-coupled': [3025], 'vitrotranscription/translation': [3027], 'system': [3028], '(Promega).': [3029], 'pull': [3031], 'down': [3032], 'reactions,': [3033], '50': [3034], 'μl': [3035, 3051, 3056], '50%': [3038], 'slurry': [3039], 'GST': [3041], 'fusion': [3042], 'bound': [3044, 4233], 'glutathione-Sepharose': [3046], 'incubated': [3048], '10': [3050], 'of35S-labeled': [3052], '500': [3055], 'buffer': [3059, 3109], '(20': [3060], 'mm': [3061, 3065, 3080], 'Tris,': [3062], '7.5,': [3063], '100': [3064], 'KCl,': [3066], '0.1': [3067], 'mmEDTA,': [3068], '0.05%': [3069], 'Nonidet': [3070], 'P-40,': [3071], '10%': [3072], 'glycerol,': [3073], '1': [3074, 3090], 'mg/ml': [3075], 'bovine': [3076], 'serum': [3077], 'albumin,': [3078], '0.5': [3079], 'phenylmethylsulfonyl': [3081], 'fluoride,': [3082], '1×': [3084], 'Complete': [3085], '(Roche': [3086], 'Molecular': [3087], 'Biochemicals))': [3088], '4': [3093], '°C.': [3094], 'beads': [3096], 'pelleted': [3098], 'washed': [3100], 'five': [3101], 'times': [3102], 'buffer.': [3106], 'reducing': [3108], 'beads,': [3114], 'samples': [3115], 'boiled': [3117], '5': [3119], 'min,': [3120], 'eluted': [3123], 'analyzed': [3126], 'SDS-PAGE.': [3128], 'gels': [3130], 'fixed': [3132], 'dried,': [3134], 'band': [3136], 'intensities': [3137], 'quantified': [3139], 'phosphorimage': [3141], 'analysis': [3142], 'Bio-Rad': [3145], 'GS': [3146], '525': [3147], 'molecular': [3148], 'imaging': [3149], 'system.DISCUSSIONThe': [3150], 'data': [3151], 'presented': [3152], 'here': [3153], 'provide': [3154], 'several': [3155, 3363], 'lines': [3156], 'evidence': [3158], 'represents': [3163], 'First,': [3178], 'clones': [3182], 'isolated': [3184], 'screen.': [3192], '-γ': [3200], 'verified': [3203], 'assays.': [3208, 3260], 'Specific': [3209], 'mapped': [3213, 3956], 'interface': [3218, 3319, 3941, 4213], 'both': [3220, 3252], 'thereby': [3224], 'indicating': [3225], 'specificity': [3227, 4294], 'Interestingly,': [3231, 3776, 4169], 'domain': [3235, 3427], 'molecule': [3239], 'Second,': [3249], 'coactivated': [3251], 'heterologous': [3258], 'promoter-reporter': [3259], 'Third,': [3261], 'involvement': [3262], 'suggested': [3270], 'parallel': [3272], 'tissue-specific': [3273], 'profiles': [3277], 'isoforms,': [3280, 4067], 'genes.': [3286], 'A': [3287], 'PGC-1α·ERR': [3291], 'controlling': [3294], 'further': [3298], 'supported': [3299], 'observation': [3302, 3422, 3527], 'ERRα-mediated': [3308], 'promoter.Mapping': [3313], 'LXXLL-type': [3323], 'Conserved': [3330], 'motifs': [3332, 3374], 'mediate': [3340, 3451], 'AF-2': [3341, 3426], 'domain-dependent': [3342], 'receptors.': [3346, 3392], 'adopts': [3350], 'α-helical': [3352, 3801], 'conformation': [3353, 4147, 4205, 4231], 'fits': [3355], 'hydrophobic': [3358], 'pocket': [3360, 3741], 'formed': [3361], 'helices': [3364], 'LBD.': [3368], 'contains': [3370], 'three': [3371, 3657, 4134], '(L1–L3)': [3375], 'although': [3376, 4184], 'only': [3377], '(L2)': [3379], 'play': [3385], 'major': [3387], 'mutagenesis': [3394], 'L3': [3406, 3444, 3494, 3705, 3817, 3839], 'motif.': [3407, 3703], 'Identification': [3408], 'consistent': [3419, 3853], 'example': [3440], 'found': [3449], 'beyond': [3460], 'GR': [3468], 'indicate': [3491], 'it': [3505], 'sufficient': [3507], 'bind': [3509], 'ERRα.': [3510], 'This': [3511], 'proposed': [3512], 'most': [3517], 'NR': [3519, 3751, 3791, 4028], 'ERα': [3534, 3735, 3743, 4025, 4043, 4096, 4108], 'L2': [3539, 3674], 'site.Although': [3540], 'defines': [3542], 'consensus': [3544, 3782, 3867], 'signature': [3545], 'established': [3558], 'importance': [3560], 'residues': [3562, 3692, 3797, 3834, 4044, 4062, 4102, 4172, 4186], 'flanking': [3563, 3666], 'determining': [3568], 'selectivity': [3570], 'affinity': [3573, 3877], '(29Chang': [3574, 3632], 'C.Y.': [3575, 3633], 'Gron': [3578, 3636], 'H.': [3579, 3637, 3992], 'Paige': [3580, 3638], 'Hamilton': [3582, 3640], 'P.T.': [3583, 3641], 'Kenan': [3584, 3642], 'D.J.': [3585, 3643], 'Fowlkes': [3586, 3644], '19:': [3594, 3652], '8226-8239Google': [3595, 3653], '30McInerney': [3597], 'E.M.': [3598], 'Rose': [3599], 'D.W.': [3600], 'Flynn': [3601], 'S.E.': [3602], 'Westin': [3603, 4004], 'Mullin': [3605], 'T.-M.': [3606], 'Krones': [3607], 'Inostroza': [3609], 'Torchia': [3611], 'R.T.': [3614, 4001], 'Assa-Munt': [3615], 'N.': [3616], 'Milburn': [3617, 4018], 'M.V.': [3618, 4019], 'Glass': [3619, 4016], 'C.K.': [3620, 4017], 'Rosenfeld': [3621, 4012], 'M.G.': [3622, 4013], 'Genes': [3623, 4257], 'Dev.': [3624, 4258], '12:': [3626], '3357-3368Google': [3627], 'Chang': [3629], 'recently': [3655], 'defined': [3656], 'upon': [3664], 'conserved': [3665, 4064], 'residues.': [3667], 'According': [3668], 'scheme,': [3671], 'class': [3678], 'III': [3679], 'determined': [3682], 'part': [3684], 'presence': [3687, 3779], 'Leu': [3689, 3699], 'Ser': [3691], 'positioned': [3693], 'motif,': [3706], 'interacts,': [3711], 'appears': [3712], 'inverted': [3716], 'and,': [3718], 'therefore,': [3719], 'does': [3720, 3861], 'readily': [3722], 'conform': [3723, 3824], 'classification': [3726], 'scheme.': [3727], 'crystal': [3730], 'structure': [3731], 'recognize': [3745], 'LXXφL': [3747], 'box': [3752], 'intermediary': [3757, 3788, 4032], '2': [3759, 3790, 4034], '(31Pike': [3761, 3970], 'A.C.W.': [3762, 3971], 'Brzozowski': [3763, 3972], 'A.M.': [3764, 3973, 4242, 4268], 'Hubbard': [3765, 3974], 'R.E.': [3766, 3975], 'Steroid': [3768, 3977], '74:': [3773, 3982], '261-268Google': [3774, 3983], 'despite': [3777], 'box,': [3792], 'constraints': [3793], 'placed': [3794], 'basic': [3796, 3833], 'N-terminal': [3798], 'shifted': [3803], 'residue': [3809], 'changing': [3810], 'recognition': [3812, 3847], 'LXXYL.': [3815], 'does,': [3821], 'fact,': [3823], 'LXXYL': [3827, 3840], 'consensus.': [3828], 'series': [3831], 'lie': [3835], 'contribute': [3844, 4199], 'findings,': [3856], 'L1': [3858], '(LLavL)': [3860], 'either': [3864, 4110], 'sequences': [3868], 'any': [3881], 'AF-2-dependent': [3884], '(present': [3905], 'study).The': [3906], 'basis': [3907], 'L2-dependent': [3919], 'unknown': [3925], 'presumably': [3928], 'structural': [3931, 4071], 'differences': [3932, 4072, 4197, 4202], 'LBDs.': [3937], 'precisely': [3947], 'defined.': [3948], 'sites': [3953], 'PPARγ,': [3964], 'retinoid': [3966], 'X': [3967], '32Bourgult': [3985], 'W.': [3986, 4252], 'Ruff': [3987], 'Chambon': [3989], 'Gronemeyer': [3991], 'Moras': [3993], '1995;': [3996], '375:': [3997], '377-382Google': [3998], '33Wisely': [4000], 'G.B.': [4003], 'Cobb': [4006], 'Lambert': [4008], 'M.H.': [4009], 'Kurokawa': [4010], 'Willson': [4014], 'T.M.': [4015], '395:': [4022], '137-143Google': [4023], 'boxes': [4029], 'direct': [4036], 'contacts': [4037], 'α-helix': [4041], 'Glu-542,': [4045], 'resides': [4047, 4055], 'LBD': [4049, 4075, 4091, 4151, 4204], 'helix': [4050, 4057], '12,': [4051], 'Lys-362,': [4053], '3.': [4058], 'Both': [4059], 'suggesting': [4068], 'their': [4082], 'differential': [4083], 'Modeling': [4087], 'reveals': [4097], '16': [4099], '19': [4101], 'identical': [4111], 'conservative': [4113], 'mismatches': [4114], '(34Chen': [4117, 4154], 'Yan': [4121, 4158], 'Sherman': [4123, 4160], '28465-28470Google': [4130, 4167], 'Of': [4132], 'residues,': [4136], 'Phe-329': [4137], 'constitutively': [4145], 'active': [4146], 'adopted': [4148], 'findings': [4181, 4290], 'that,': [4183], 'binding,': [4193], 'slight': [4201], 'among': [4206], 'receptors': [4208, 4234], 'influence': [4210], 'Lastly,': [4216], 'allosteric': [4223], 'elements': [4228], '(35Wood': [4235], 'J.R.': [4236, 4254, 4264], 'Likhite': [4237], 'V.S.': [4238], 'Loven': [4239], 'M.A.': [4240], 'Nardulli': [4241, 4267], 'Endocrinol.': [4244], '15:': [4246], '1114-1126Google': [4247], '36Starr': [4249], 'D.B.': [4250], 'Matsui': [4251], 'Thomas': [4253], 'Yamamoto': [4255], 'K.R.': [4256], '10:': [4260], '1271-1283Google': [4261], '37Wood': [4263], 'Greene': [4265], 'G.L.': [4266], '18:': [4273], '1927-1934Google': [4274], '38Ikeda': [4276], 'Wilcox': [4278], 'E.C.': [4279], '271:': [4286], '23096-23104Google': [4287], 'pr': [4302]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2000065704', 'counts_by_year': [{'year': 2024, 'cited_by_count': 17}, {'year': 2023, 'cited_by_count': 20}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 21}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 23}, {'year': 2013, 'cited_by_count': 22}, {'year': 2012, 'cited_by_count': 31}], 'updated_date': '2024-12-13T04:09:04.354331', 'created_date': '2016-06-24'}