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674, 688, 1010, 1469, 1511, 2406, 2812, 2984, 3170, 3397, 3550, 3799, 4403], 'experiments': [291], 'II:': [303], 'Less': [304], 'than': [305, 3791], 'but': [308, 336, 352, 3392], 'one': [311], 'RCT': [312], 'expert': [321], 'opinion': [322], 'papers': [323], 'literature': [325], 'intervention.': [329], 'Experimental': [330], 'quite': [334], 'convincing,': [335], 'yet': [338], 'supported': [339], 'adequate': [341, 618, 2750, 4404], 'experience.': [343], 'III:': [345], 'Suggestive': [346], 'data': [347, 355, 629], 'lacking': [353], 'sufficient': [354, 452, 4407], 'such': [356, 4103, 4153, 4178], 'meta-analysis,': [358], 'RCT,': [359], 'series.': [363], 'Note:': [364], 'suggestion': [366], 'can': [370, 643, 656, 1009, 1510, 2811, 3396, 3549, 4187, 4203], 'positive': [372], 'negative': [374], 'proposed': [377], 'level': [378, 2346, 2380, 2744, 2755, 3751, 4420], '(e.g.,': [379], 'meta-analysis': [380, 3480, 3620], 'stating': [384], 'use': [389, 750, 1193, 2767, 3505], 'treating': [391, 2987, 3045], 'ulcers).': [393], 'been': [396, 1457, 2392, 2978, 3581, 4035], 'formulated': [397], 'eight': [399], 'categories': [400, 412], 'extremities.': [410], 'Diagnosis': [414], 'Offloading': [415, 1450], 'Infection': [416, 2026, 2042, 3966], 'control': [417], 'bed': [419, 2220, 3981, 4007, 4032, 4046], 'preparation': [420, 2221, 3982, 4008, 4033], 'Dressings': [421, 3969], 'Surgery': [422, 4370], 'Adjuvant': [423, 3972], 'agents': [424, 3076, 4198], '(topical,': [425], 'device,': [426], 'systemic)': [427], 'Prevention': [428], 'recurrence': [430], 'Each': [431], 'separate': [434, 459], 'undergoing': [437, 4206], 'Delphi': [439], 'among': [441], 'members.': [444, 477], 'Not': [445], 'all': [446, 456, 2060, 4188], 'members': [448], 'thought': [449], 'they': [450], 'had': [451], 'expertise': [453], 'critique': [455], 'sections': [460], 'However,': [464, 3538], 'each': [465], 'set': [466], 'critically': [470], 'evaluated': [471], 'ten': [475], 'Preamble:': [478, 1427, 2025, 3979], 'Ulcers': [479], 'extremity': [483, 667, 723, 840], 'may': [484, 613, 1052, 1430, 4192], 'caused': [486, 2425, 2445, 2824], 'variety': [489], 'conditions,': [491], 'neuropathy,': [493, 1482], 'ischemia,': [494, 516], 'venous': [495, 2301], 'hypertension,': [496], 'pressure.': [498, 1049], 'Patients': [499, 4205], 'secondary': [504], 'neuropathy': [506, 1008, 1051, 1107], 'without': [509], 'biomechanical': [510], 'abnormalities,': [511], 'peripheral': [512, 899, 962, 1106, 1354], 'vascular': [513, 753], 'disease': [514, 556, 679, 795, 901, 1417, 4149], 'both.': [518], '20': [521, 2686, 3055], 'million': [522], 'people': [523, 1238], 'United': [526], 'States': [527], 'diabetes,': [529], 'whom': [531], '10–15%': [532], 'risk': [535, 1163, 1241, 1325, 1382, 1475, 1507, 4227], 'ulceration.': [537, 1328, 1386, 3083], 'It': [538], 'imperative': [540], 'etiology': [543, 633, 663], 'established': [545], 'provide': [547, 4406], 'proper': [549], 'therapy.': [550, 3342, 3556, 4389], 'Guideline': [551, 1002, 1464, 1731, 2057, 2312, 2730, 2955, 3147, 3348, 3520, 3746, 4081], '#1.1:': [552], 'Clinically': [553], 'arterial': [555, 619, 646, 678, 686, 724, 794, 900, 963, 1479], 'should': [557, 1468, 2405, 3169], 'ruled': [559], 'out': [560], 'establishing': [562, 3400], 'pedal': [564, 3427], 'pulses': [565], 'clearly': [567], 'palpable': [568], 'ankle': [572], ':': [573, 600, 2031], 'brachial': [574, 601], 'index': [575, 602, 2268], '(ABI)': [576], '>0.9.': [578], 'An': [579, 1681], 'ABI': [580, 592], '>1.3': [581], 'suggests': [582], 'noncompressible': [583], 'arteries.': [584], 'elderly': [586], 'an': [591, 617, 631, 661, 713, 1433, 1957, 2447, 2826, 3245, 4024, 4461], '>1.2,': [593], 'normal': [595, 3192], 'Doppler-derived': [596], 'waveform,': [597], 'toe': [599, 709], '>0.7,': [604], 'transcutaneous': [607], 'oxygen': [608, 984], 'pressure': [609, 711, 1031, 1350, 1409, 1436, 1455, 1769, 1938], '>40': [611], 'mmHg': [612], 'help': [614, 4131], 'suggest': [616], 'flow.': [620], 'Color': [621], 'duplex': [622, 829], 'ultrasound': [623], 'scanning': [624], 'provides': [625], 'anatomic': [626], 'physiologic': [628], 'confirming': [630], 'ischemic': [632, 662, 992], 'leg': [636, 2302, 2701, 2722, 2856, 2903, 2947], 'wound.': [637, 4027], '(Level': [638, 1021, 1496, 1765, 2073, 2364, 2792, 2972, 3177, 3373, 3557, 3781, 4118], 'I)': [639, 1766, 2793, 4119], 'Principle:': [640, 1023, 1498, 1767, 2084, 2366, 2794, 2974, 3179, 3375, 3559, 3783, 4120, 4399], 'result': [644, 1431], 'insufficiency': [647, 687], 'neuropathy.': [649, 1355, 1449], 'Although': [650, 2992, 4442], 'history': [652], 'physical': [654], 'examination': [655, 1103, 1270], 'very': [658], 'suggestive': [659], 'ulcers,': [669], 'definitive': [671, 3390], 'diagnosis': [672, 3402, 3453, 3732], 'must': [673, 4402], 'established.': [675], 'When': [676, 3578], 'present,': [681], 'successful': [682], 'requires': [684], 'addressed.': [689], 'Evidence:': [690, 1059, 1517, 1780, 2110, 2415, 2814, 3022, 3211, 3411, 3608, 3814, 4230, 4465], 'Sahli': [691], 'D,': [692, 774, 784, 879, 1063, 1225, 1260, 1262, 1302, 1790, 1820, 2164, 2166, 3125, 3468, 3610, 4063, 4238], 'Eliasson': [693, 699], 'B,': [694, 1786], 'Svensson': [695], 'M,': [696, 700, 741, 772, 778, 788, 790, 1096, 1258, 1308, 1541, 1543, 1794, 1920, 2143, 2168, 2463, 3065, 3447, 3726, 3928, 4305, 4469], 'Blohme': [697], 'G,': [698, 1703, 1875, 1916, 2289, 2291, 4242, 4479], 'Samuelsson': [701], 'P,': [702, 739, 1152, 1343, 1713, 1912, 1950, 2001, 2632, 2844], 'Ojbrandt': [703], 'K,': [704, 1082, 1090, 1118, 1591, 2638, 2644, 3257, 3417, 3470, 3612], 'Eriksson': [705], 'J.': [706, 1158, 1191, 1603, 3697, 4481], 'Assessment': [707], 'blood': [710], 'effective': [714, 1315, 1658], 'screening': [715, 1318, 1378], 'method': [716, 2572], 'identify': [718, 1237], 'disease.': [725], 'Angiology': [726], '2004;': [727, 763, 851, 1144, 1646, 1868, 1962, 3054, 4371, 4393], '55:': [728], '641–51.': [729], '[CLIN': [730, 807, 854, 1000, 1115, 1147, 1186, 1255, 1297, 1336, 1363, 1393, 1425, 1538, 1675, 1696, 1907, 1945, 2023, 2669, 2711, 2913, 3442, 3518, 4346], 'S]': [731, 808, 855, 1001, 1116, 1148, 1187, 1256, 1298, 1337, 1364, 1394, 1426, 1539, 1676, 1697, 1872, 1908, 1946, 1999, 2024, 2670, 2712, 2914, 3443, 3519, 4347], 'Teodorescu': [732], 'V,': [733, 1154, 1156, 1922, 4042, 4471], 'Chen': [734], 'C,': [735, 1227, 1589, 1595, 1631, 1827, 2640, 2642, 2842, 2846], 'Morrissey': [736], 'N,': [737, 814, 1061, 1080, 2145, 3063, 4475], 'Faries': [738], 'Marin': [740], 'Hollier': [742], 'L.': [743, 1831], 'Detailed': [744], 'protocol': [745], 'ischemia': [747], 'noninvasive': [752, 1171], 'testing': [755, 1013, 1172], 'ulcers.': [759, 1724, 1812, 2056, 2189, 2278, 2303, 2403, 2501, 2702, 2723, 2904, 2948, 3428], 'Am': [760, 2191, 2454, 2521, 2624, 2833, 2887, 3919, 4390], 'J': [761, 994, 1109, 1140, 1180, 1212, 1290, 1356, 2190, 2305, 2584, 2625, 2664, 2888, 2931, 3248, 3270, 3311, 3682, 3714, 3899, 4341, 4391], 'Surg': [762, 850, 995, 1143, 2193, 2257, 2430, 2451, 2518, 2626, 2706, 2830, 2889, 2908, 3461, 3514, 3717, 3740, 3832, 3859, 3876, 3900, 3916, 4342, 4392], '187': [764, 4394], '(5A):': [765, 4395], '75S–80.': [766], '[LIT': [767, 1077, 1220, 1582, 1649, 1967, 2215, 2239, 2310, 2434, 2458, 2506, 2525, 2690, 2837, 2936, 3114, 3254, 3278, 3296, 3320, 3465, 3659, 3688, 3744, 3836, 3923, 4283, 4397], 'REV]': [768, 1078, 1221, 1583, 1650, 1968, 2216, 2240, 2311, 2435, 2459, 2507, 2526, 2691, 2838, 2937, 3115, 3255, 3279, 3297, 3321, 3466, 3660, 3689, 3745, 3837, 3924, 4284, 4398], 'Hirsch': [769, 856], 'A,': [770, 786, 812, 820, 1150, 1304, 1709, 1711, 1784, 1829, 1879, 1910, 3123, 3474, 4353], 'Criqui': [771], 'Treat-Jacobson': [773], 'Regensteiner': [775], 'J,': [776, 780, 888, 1189, 1231, 1266, 1339, 1402, 1792, 1948, 3472, 3614, 4477], 'Creager': [777, 864], 'Olin': [779, 872], 'Krook': [781], 'S,': [782, 824, 1084, 1300, 1593, 1633, 1881, 2003, 3061, 3325], 'Hunninghake': [783], 'Comerota': [785], 'Walsh': [787], 'McDermott': [789], 'Hiatt': [791], 'W.': [792, 2248, 3305], 'Peripheral': [793], 'detection,': [796], 'awareness,': [797], 'primary': [801], 'care.': [802], 'JAMA': [803, 1073, 1620, 3438], '2001;': [804, 1183, 1843, 2485, 2933, 3275, 3492, 3632, 3950], '286:': [805], '1317–24.': [806], 'Ascher': [809], 'E,': [810, 1264, 1306, 1545, 1652, 1678, 1701, 3217, 3419, 3841], 'Hingorani': [811], 'Markevich': [813], 'Yorkovich': [815], 'W,': [816], 'Schutzer': [817], 'R,': [818, 1094, 1341, 1850, 1852, 2293, 2918, 4240, 4288], 'Hou': [819], 'Jacob': [821], 'T,': [822, 1088, 1654, 3327, 4331], 'Nahata': [823], 'Kallakuri': [825], 'S.': [826, 1122, 1924, 4290], 'Role': [827, 2542], 'arteriography': [830], 'sole': [833], 'preoperative': [834], 'imaging': [835], 'modality': [836], 'prior': [837], 'revascularization': [841], 'surgery': [842, 4208], 'renal': [846], 'patients.': [847, 1282, 1531, 3437], 'Ann': [848, 2256, 2703, 2905, 3858], 'Vasc': [849], '18:': [852, 1728, 3879], '433–439.': [853], 'AT,': [857], 'Haskal': [858], 'ZJ,': [859], 'Hertzer': [860], 'NR,': [861], 'Bakal': [862], 'CW,': [863], 'MA,': [865, 1972], 'Halperin': [866], 'JL,': [867], 'Hiratzka': [868], 'LF,': [869], 'Murphy': [870, 3882], 'WRC,': [871], 'JW,': [873], 'Puschett': [874], 'JB,': [875], 'Rosenfield': [876], 'KA,': [877], 'Sacks': [878], 'Stanley': [880], 'JC,': [881], 'Taylor': [882, 2294], 'LM': [883], 'Jr,': [884], 'White': [885, 887, 889, 2915], 'CJ,': [886], 'RA.': [890], 'ACC/AHA': [891], 'management': [895, 958, 1418, 1806, 3455, 3710, 3734, 3987], '(lower': [902], 'extremity,': [903], 'renal,': [904], 'mesenteric,': [905], 'abdominal': [907], 'aortic):': [908], 'collaborative': [910], 'report': [911, 3037], 'American': [914, 940, 965, 1551, 1570], 'Association': [915, 945], 'Vascular': [917, 920, 934], 'Surgery/Society': [918], 'Surgery,': [921], 'Society': [922, 928, 932], 'Cardiovascular': [924], 'Angiography': [925], 'Interventions,': [927], 'Interventional': [930], 'Radiology,': [931], 'Medicine': [935], 'Biology,': [937], 'College': [941, 966], 'Cardiology/American': [943], 'Heart': [944], 'Task': [946], 'Force': [947], 'Practice': [949], '(writing': [951], 'committee': [952], 'disease).': [964], 'Cardiology': [968], 'Web': [969], 'site.': [970], 'Available': [971], 'at:': [972], 'http://www.acc.org/clinical/guidelines/pad/index.pdf.': [973], '[STAT]': [974, 2162, 2630, 3059, 3090, 3495, 3635, 4261], 'Padberg': [975], 'FT,': [976], 'Back': [977], 'TL,': [978, 1372], 'Thompson': [979], 'PN,': [980], 'Hobson': [981], 'RW.': [982], 'Transcutaneous': [983], '(TcPO2)': [985], 'estimates': [986], 'probability': [987], 'healing': [989, 1778, 1981, 2185, 2397, 2423, 2444, 2478, 2659, 2823, 2858, 3943, 3994, 4026, 4164, 4190, 4202, 4224, 4317], 'Res': [996, 1330, 1358, 3052, 3107, 3652, 3901], '1996;': [997, 2194, 3462, 3741, 4343], '60:': [998], '365–9.': [999], '#1.2:': [1003], 'presence': [1005, 4142], 'determined': [1011], '10': [1016], 'gram': [1017, 3795], '(5.07)': [1018], 'Semmes–Weinstein': [1019, 1101, 1196, 1311], 'monofilament.': [1020], 'II)': [1022, 1497, 2365, 2973, 3178, 3374, 3558, 3782], 'Neuropathy': [1024], 'leads': [1025], 'deformity': [1028, 1135], 'abnormal': [1030], 'foot,': [1034], 'plantar': [1037, 1808, 1863, 1896], 'surface.': [1038], 'Lack': [1039], 'protective': [1041, 1275, 1515], 'sensation': [1042, 1276, 1351], 'allows': [1043], 'ulceration': [1044, 1205, 1429, 1502, 1509], 'areas': [1046], 'high': [1048, 1240, 1381, 1454, 3405], 'Autonomic': [1050], 'increase': [1053, 1434], 'likelihood': [1055], 'skin': [1057, 3155, 3200, 3221, 3285, 3287, 3773, 3775, 3854, 3873, 4269], 'breakdown.': [1058], 'Singh': [1060], 'Armstrong': [1062, 1224, 1367, 1397, 1789, 1819, 3118], 'Lipsky': [1064, 2491, 3023, 3091, 3116, 3636, 3663], 'B.': [1065, 2562, 3024], 'Preventing': [1066], 'diabetes.': [1072, 1139, 1211], '2005;': [1074, 1112, 1535, 1579, 1815, 2307, 2503, 3143, 3317, 3344, 3685], '293:': [1075], '217–28.': [1076], 'Kamei': [1079], 'Yamane': [1081], 'Nakanishi': [1083], 'Yamashita': [1085], 'Y,': [1086], 'Tamura': [1087], 'Ohshita': [1089], 'Watanabe': [1091], 'H,': [1092, 1223, 1822, 1848, 1877, 3822], 'Fujikawa': [1093], 'Okubo': [1095], 'Kohno': [1097], 'N.': [1098, 1547], 'Effectiveness': [1099, 1636], 'monofilament': [1102, 1197], 'screening.': [1108], 'Diab': [1110, 1181, 1329], '19:': [1113], '47–53.': [1114], 'Foltz': [1117], 'Fallat': [1119], 'L,': [1120, 1229, 1699, 1707, 1788, 1824, 1914, 3323, 3662, 4473], 'Schwartz': [1121], 'Usefulness': [1123], 'brief': [1126], 'assessment': [1127, 1410, 3509, 4249], 'battery': [1128], 'early': [1130], 'detection': [1131, 1273], 'Charcot': [1133], 'Foot': [1141, 1532, 1553, 1572, 1576, 1865, 1953, 2673], 'Ankle': [1142, 1533, 1555, 1574, 1577, 1866], '43:': [1145], '87–92.': [1146], 'Jirkovska': [1149], 'Boucek': [1151], 'Woskova': [1153], 'Bartos': [1155], 'Skibova': [1157], 'Identification': [1159], 'foot:': [1166], 'comparison': [1168, 3699], 'standardized': [1170], 'routine': [1174], 'practice': [1175, 3097, 3642], 'community': [1177], 'clinics.': [1179], '15:': [1184, 1996, 3318], '63–68.': [1185], 'Mayfield': [1188], 'Sugarman': [1190], 'other': [1199, 4000], 'threshold': [1200], 'tests': [1201], 'preventing': [1203, 1642], 'persons': [1209], 'Fam': [1213], 'Pract': [1214, 1332], '2000;': [1215, 1252, 3087, 3109, 3251, 3654, 4078, 4300], '49': [1216], '(Suppl.': [1217, 1964, 2687, 2870, 3056, 3111, 3656, 4280], '11):': [1218], 'S17–29.': [1219], 'Pham': [1222], 'Harvey': [1226], 'Harkless': [1228, 1830], 'Giurini': [1230], 'Veves': [1232, 1303], 'A.': [1233, 1310, 1796, 1885, 2920, 3329], 'Screening': [1234], 'techniques': [1235, 3395], 'ulceration:': [1245], 'prospective': [1247], 'multicenter': [1248], 'trial.': [1249, 1618, 1840, 3141], 'Diabetes': [1250, 1420, 1548, 1566, 1644, 1670, 1691, 1725, 1813, 1841, 1902, 1940, 3050, 3105, 3650], 'Care': [1251, 1421, 1645, 1726, 1814, 1842, 1903, 1941, 1994, 4276], '23:': [1253], '606–11.': [1254], 'Smieja': [1257], 'Hunt': [1259], 'Edelman': [1261], 'Etchells': [1263], 'Cornuz': [1265], 'Simel': [1267], 'D.': [1268, 1519, 2646], 'Clinical': [1269, 1287], 'feet': [1279], 'International': [1283, 3025], 'Cooperative': [1284], 'Group': [1285, 3027], 'Examination': [1288, 4083], 'Research.': [1289], 'Gen': [1291], 'Intern': [1292], 'Med': [1293, 1389, 1671, 1692, 2018, 3236, 3315, 3460, 3739, 4277], '1999;': [1294, 2890, 3719], '14:': [1295, 2237, 2308, 3252], '418–24.': [1296], 'Kumar': [1299], 'Fernando': [1301], 'Knowles': [1305, 2717, 2942], 'Young': [1307], 'Boulton': [1309, 1403, 1795, 1828], 'monofilaments:': [1312], 'simple,': [1314], 'inexpensive': [1317], 'device': [1319], 'identifying': [1321, 4133, 4435], 'Clin': [1331, 1959, 2210, 2428, 2452, 2519, 2682, 2831, 3233, 3458, 3737, 3830, 3917], '1991;': [1333], '13:': [1334, 3463, 3742], '63–7.': [1335], 'Holewski': [1338], 'Stess': [1340], 'Graf': [1342], 'Grunfeld': [1344], 'C.': [1345, 1854], 'Aesthesiometry:': [1346], 'quantification': [1347], 'cutaneous': [1349, 2204, 4295], 'Rehabil': [1357, 2019], 'Dev': [1359], '1988;': [1360], '25:': [1361, 1869], '1–10.': [1362], 'Lavery': [1365, 1395, 1823], 'LA,': [1366, 1396], 'DG,': [1368, 1398, 1587, 1629, 3119], 'Vela': [1369], 'SA,': [1370], 'Quebedeaux': [1371], 'Fleischli': [1373], 'JC.': [1374], 'Practical': [1375], 'criteria': [1376], 'Arch': [1387, 2016, 2724, 2949, 4256], 'Int': [1388, 1534, 1578, 1867, 3247, 3681], '1998;': [1390], '158:': [1391], '157–62.': [1392], 'Wunderlich': [1399], 'RP,': [1400], 'Tredwell': [1401], 'AJ.': [1404], 'Predictive': [1405], 'value': [1406], 'part': [1412], 'population-based': [1415], 'program.': [1419], '2003;': [1422, 1904, 1942, 2666, 3293, 4057, 4278], '26:': [1423, 1536, 1580, 1905, 1943], '1069–73.': [1424], 'because': [1441], 'deformity,': [1444, 1491], 'limited': [1445], 'joint': [1446, 3487, 3627], 'mobility,': [1447], 'area': [1452], 'has': [1456, 3580], 'mainstay': [1459], 'prevent': [1461], 'these': [1462], 'problems.': [1463], '#2.1:': [1465], 'Protective': [1466], 'footwear': [1467, 1528, 1607, 1640, 1662], 'prescribed': [1470], 'any': [1472, 2742, 2775], 'patient': [1473, 1689, 4086], '(significant': [1478], 'insufficiency,': [1480], 'previous': [1483, 1485], 'amputation,': [1484], 'formation,': [1487], 'preulcerative': [1488], 'callus,': [1489], 'callus': [1494], 'formation).': [1495], 'incidence': [1500, 3804], 'reduced': [1512], 'using': [1514, 1982], 'footwear.': [1516], 'Janisse': [1518], 'Therapeutic': [1521], 'Shoe': [1522], 'Bill:': [1523], 'medicare': [1524], 'coverage': [1525], 'prescription': [1527], '42–5.': [1537], 'Pinzur': [1540], 'Slovenkai': [1542], 'Trepman': [1544], 'Shields': [1546], 'Committee': [1549, 1567], 'Orthopaedic': [1552, 1571], 'care:': [1561], 'recommendations': [1562], 'endorsed': [1563], '113–9.': [1581], 'Reiber': [1584, 1626], 'GE,': [1585, 1627], 'Smith': [1586, 1628, 2878], 'Wallace': [1588, 1630], 'Sullivan': [1590], 'Hayes': [1592, 1632], 'Vath': [1594], 'Maciejewski': [1596, 1624], 'ML,': [1597, 1625, 2242, 3413], 'Yu': [1598], 'O,': [1599], 'Heagerty': [1600], 'PJ,': [1601], 'LeMaster': [1602], 'Effect': [1604, 2177, 4356], 'therapeutic': [1606, 1639, 1661, 2233, 4001], 'reulceration': [1610], 'diabetes:': [1614, 1956], 'randomized': [1616, 1798, 1838], 'controlled': [1617], '2002;': [1619, 1995, 2236, 2282, 2868], '287:': [1621], '2552–8.': [1622], '[RCT]': [1623, 1730, 1818, 1846, 2197, 2285, 2488, 2729, 2873, 2893, 2954, 3146, 3347, 3722, 3881, 3953, 4374], 'Boyko': [1634], 'EJ.': [1635], 'reulceration.': [1643], '27:': [1647], '1774–82.': [1648], 'Chantelau': [1651, 1677], 'Kushner': [1653], 'Spraul': [1655], 'M.': [1656, 2295, 3127, 3824, 3889, 4244], 'How': [1657], 'cushioned': [1660, 1684], 'protecting': [1664], 'feet?': [1666], 'A': [1667, 1797, 1837, 3429, 3698, 4122, 4308, 4482], 'study.': [1669, 2866], '1990;': [1672, 2431, 2708, 2910], '7:': [1673], '355–9.': [1674], 'Haage': [1679], 'P.': [1680], 'audit': [1682], 'footwear:': [1686], 'relation': [1687], 'compliance.': [1690, 1901], '1994;': [1693, 4258], '11:': [1694, 4058], '114–6.': [1695], 'Uccioli': [1698], 'Faglia': [1700], 'Monticone': [1702], 'Favales': [1704], 'F,': [1705, 1883, 1918, 4329], 'Durola': [1706], 'Aldeghi': [1708], 'Quarantiello': [1710], 'Calia': [1712], 'Menzinger': [1714], 'G.': [1715, 1952, 2005, 2496, 2848], 'Manufactured': [1716], 'shoes': [1717], 'prevention': [1720], '1995;': [1727, 2685, 3439], '1376–8.': [1729], '#2.2:': [1732], 'Acceptable': [1733], 'methods': [1734, 1985], 'offloading': [1736, 2340], 'include': [1737, 3357], 'crutches,': [1738], 'walkers,': [1739], 'wheelchairs,': [1740], 'custom': [1741, 1747, 1749], 'shoes,': [1742, 1744, 1760], 'depth': [1743], 'shoe': [1745], 'modifications,': [1746], 'inserts,': [1748], 'relief': [1750, 1759], 'orthotic': [1751], 'walkers': [1752], '(CROW),': [1753], 'boots,': [1755], 'forefoot': [1756, 1979], 'heel': [1758], 'total': [1762, 1858], 'contact': [1763, 1859, 2007], 'casts.': [1764], 'Relieving': [1768], 'wound': [1773, 2122, 2254, 2443, 2477, 2617, 2658, 2822, 2884, 3071, 3360, 3785, 3806, 3942, 3990, 4006, 4020, 4031, 4052, 4068, 4163, 4201, 4223, 4296, 4316], 'necessary': [1775], 'maximize': [1777], 'potential.': [1779], 'Katz': [1781], 'Harlan': [1783], 'Miranda-Polma': [1785], 'Prieto-Sanchez': [1787], 'Bowker': [1791], 'Mizel': [1793], 'trial': [1799, 4484], 'irremovable': [1802], 'off-loading': [1803, 1984], 'devices': [1804], 'neuropathic': [1809, 1933, 2013], '28:': [1816], '555–9.': [1817], 'Nguyen': [1821], 'van': [1825], 'Schie': [1826], 'Off-loading': [1832], 'wound:': [1836], '24:': [1844], '1019–22.': [1845], 'Hartsell': [1847], 'Brand': [1849], 'Frantz': [1851], 'Saltzman': [1853], 'effects': [1856, 1936, 2778], 'casting': [1860, 2008], 'materials': [1861], 'pressures.': [1864], '73–8.': [1870], '[Clin': [1871], 'Ha': [1873], 'Van': [1874], 'Siney': [1876], 'Hartmann-Heurtier': [1878], 'Jacqueminet': [1880], 'Greau': [1882], 'Grimaldi': [1884], 'Nonremovable,': [1886], 'windowed,': [1887], 'fiberglass': [1888], 'cast': [1889], 'boot': [1890], 'ulcers:': [1897, 2205], 'efficacy,': [1898], 'safety': [1899], '2848–52.': [1906], 'Piaggesi': [1909], 'Viacava': [1911], 'Rizzo': [1913], 'Naccarato': [1915], 'Baccetti': [1917], 'Romanelli': [1919], 'Zampa': [1921], 'Del-Prato': [1923], 'Semiquantitative': [1925], 'analysis': [1926], 'histopathologic': [1929], 'features': [1930], 'ulcer:': [1935], 'relief.': [1939], '3123–8.': [1944], 'Ulbrecht': [1947], 'Cavanagh': [1949, 2489], 'Caputo': [1951], 'problems': [1954], 'overview.': [1958], 'Infect': [1960, 2683, 3490, 3630, 3683], 'Dis': [1961, 2684, 3491, 3631, 3684], '39': [1963], '2):': [1965, 2688], 'S73–82.': [1966], 'Birke': [1969], 'JA,': [1970, 2199], 'Pavich': [1971], 'Patout': [1973], 'CA,': [1974], 'Horswell': [1975], 'R.': [1976], 'Comparison': [1977], 'alternative': [1983], 'Adv': [1991], 'Skin': [1992, 3262], '210–5.': [1997], '[RETRO': [1998], 'Helm': [2000], 'Walker': [2002], 'Pullium': [2004], 'Total': [2006], 'ulcerations.': [2015], 'Phys': [2017], '1984;': [2020, 2522, 3920], '65:': [2021], '691–3.': [2022], 'results': [2027], 'bacteria': [2030, 2090, 2370, 2580, 3847], 'host': [2032], 'defense': [2033], 'equilibrium': [2034], 'upset': [2036], 'favor': [2038], 'bacteria.': [2041, 2414, 2450, 2829], 'plays': [2043], 'various': [2044, 2387], 'roles': [2045], 'etiology,': [2048], 'healing,': [2049], 'operative': [2050], 'repair,': [2051], 'complications': [2053], '#3.1:': [2058], 'Remove': [2059], 'necrotic': [2061], 'devitalized': [2063, 2092], 'tissue': [2064, 2086, 2093, 2355, 2376, 2379, 2740, 2743, 3013, 3158, 3203, 3750, 3759, 3797, 3828, 3961, 4098, 4114, 4174], 'surgical,': [2066], 'enzymatic,': [2067], 'mechanical,': [2068], 'biological,': [2069], 'autolytic': [2071], 'debridement.': [2072], 'II;': [2074], 'detailed': [2075], 'discussion': [2076], 'debridement': [2078, 2149, 2180, 2297, 2336, 3573, 3579], 'Preparation': [2082], 'Guidelines.)': [2083, 3978], 'Necrotic': [2085], 'laden': [2088], 'while': [2091], 'impairs': [2094], "body's": [2096], 'ability': [2097], 'fight': [2099], 'infection': [2100, 2318, 2348, 3152, 3206, 3807, 3957], 'serves': [2102], 'culture': [2105, 2566], 'medium': [2106], 'bacterial': [2108, 2250, 2467, 2619, 2754, 2763, 2787, 2802, 2885, 3265, 3284, 3932, 4071], 'growth.': [2109], 'Edlich': [2111, 3298, 3815], 'RF,': [2112, 3299, 3816], 'Rodeheaver': [2113, 3817], 'GT,': [2114, 3818], 'Thacker': [2115, 3819], 'JG,': [2116, 3820], 'et': [2117, 3218, 3615, 4043], 'al.': [2118, 3219, 3616, 4044], 'Technical': [2119], 'factors': [2120, 3963, 4102], 'management.': [2123, 4053], 'In:': [2124, 2533], 'Dunphy': [2125], 'JE,': [2126], 'Hun': [2127], 'TK,': [2128], 'editors.': [2129, 2538], 'Fundamentals': [2130], 'Management': [2133, 3825], 'Surgery.': [2135], 'South': [2136], 'Plainfield,': [2137], 'NJ:': [2138], 'Chirurgecom,': [2139], '1977.': [2140], '[EXP]': [2141, 2261, 3240, 3863, 3905, 4303, 4325], 'Bradley': [2142], 'Cullum': [2144, 3062], 'Sheldon': [2146, 3066], 'T.': [2147, 3067, 4376], 'wounds:': [2152, 2513, 3911, 4379], 'systematic': [2154, 4049], 'review.': [2155], 'Technol': [2157, 3085], 'Assess': [2158, 3086], '1993;': [2159], '3:': [2160], '1–78.': [2161], 'Steed': [2163], 'Donohue': [2165], 'Webster': [2167], 'Lindsley': [2169], 'L': [2170], 'Study': [2175], 'Group.': [2176], 'extensive': [2179], 'Coll': [2192, 2705, 2907], '183:': [2195], '61–4.': [2196], 'Witkowski': [2198], 'Parrish': [2200], 'LC.': [2201], 'Debridement': [2202, 2266], 'medical': [2206, 4124], 'surgical': [2208, 2399, 3770], 'aspects.': [2209], 'Dermatol': [2211, 2665, 2725, 2950, 3272], '1992;': [2212], '9:': [2213, 3686], '585–91.': [2214], 'Falanga': [2217, 2264, 4041], 'V.': [2218, 2265], 'role': [2224, 2679, 2926], 'enzymes:': [2226], 'case': [2228], 'actions': [2231], 'agents.': [2234], 'Wounds': [2235], '47–57.': [2238], 'Hamer': [2241], 'Robson': [2243, 2416, 2436, 2536, 2815, 2874, 3866, 3884, 4243], 'MC,': [2244, 2417, 2537, 2875, 3867, 3885], 'Krizek': [2245, 3864], 'TJ,': [2246, 3865], 'Southwick': [2247], 'Quantitative': [2249, 2539], 'analyses': [2251], 'comparative': [2253, 4309], 'irrigations.': [2255], '1975;': [2258], '181:': [2259], '819–22.': [2260], 'Saap': [2262], 'LJ,': [2263, 3499], 'performance': [2267], 'its': [2270], 'correlation': [2271], 'complete': [2273], 'closure': [2274, 2400, 3771], 'Rep': [2280, 4055], 'Reg': [2281, 4056], '10:': [2283, 2934, 3238], '354–9.': [2284], 'Davies': [2286, 2639], 'CE,': [2287], 'Turton': [2288], 'Woolfrey': [2290], 'Elley': [2292], 'Exploring': [2296], 'options': [2298], 'Br': [2304, 2663, 2930, 3718, 4340], 'Nurs': [2306, 2932], '393–7.': [2309], '#3.2:': [2313], 'If': [2314, 3350, 3590], 'there': [2315], 'suspected': [2317], 'debrided': [2321, 2351], 'ulcer,': [2322, 3564], 'if': [2324, 4460], 'epithelialization': [2325], 'margin': [2328], 'progressing': [2331], 'within': [2332], 'weeks': [2334, 3535], 'initiation': [2338], 'therapy,': [2341], 'determine': [2342], 'type': [2344], 'biopsy': [2356, 2618], 'validated': [2360], 'quantitative': [2361, 2564, 2597, 3507], 'swab': [2362, 2565, 2594], 'technique.': [2363], 'High': [2367, 2466, 3931], '≥1': [2371, 2735], '×': [2372, 2736], '106': [2373, 2737], 'CFU/g': [2374, 2738, 3757], 'beta': [2382, 2746, 3762], 'hemolytic': [2383, 2747, 3763], 'streptococci': [2384, 2698, 2748, 3163, 3208, 3764], 'impede': [2385, 2395], 'wound-healing': [2388, 4212], 'processes': [2389], 'demonstrated': [2393, 2979], 'spontaneous': [2396], 'Cultures': [2404], 'performed': [2407], 'isolate': [2409], 'both': [2410], 'aerobic': [2411, 2579, 3000, 3003], 'anaerobic': [2413, 3007], 'Stenberg,': [2418], 'BD,': [2419], 'Heggers,': [2420], 'JP.': [2421, 2528], 'alterations': [2424, 4166], 'infection.': [2427, 4229], 'Plast': [2429, 3512, 3831], '17:': [2432], '485–92.': [2433], 'MC.': [2437, 2816], 'infection:': [2439, 2924], 'failure': [2441, 2820], 'imbalance': [2448, 2827], 'North': [2453, 2520, 2832, 3918], '1997;': [2455, 2834, 3515], '77:': [2456, 2835], '637–50.': [2457, 2836], 'Browne': [2460, 3925], 'AC,': [2461, 3926], 'Vearncombe': [2462, 3927], 'Sibbald': [2464, 3929, 4039], 'RG.': [2465, 3930], 'load': [2468, 3933], 'asymptomatic': [2470, 3935], 'neurotrophic': [2474, 3939], 'retards': [2476, 3941], 'after': [2479, 3944, 4337], 'application': [2480, 3945], 'dermagraft.': [2482], 'Ostomy/Wound': [2483, 3948, 4076], 'Manage': [2484, 3949, 4077], '47:': [2486, 3951], '44–9.': [2487, 3952], 'PR,': [2490], 'BA,': [2492, 3092, 3117, 3259, 3637, 3664], 'Bradbury': [2493], 'AW,': [2494], 'Botek': [2495], 'Treatment': [2497, 3282], 'Lancet': [2502, 3142, 3489, 3629], '366:': [2504, 3144], '1725–35.': [2505], 'Tobin': [2508, 3812, 3906], 'GR.': [2509, 3907], 'Closure': [2510, 3908], 'contaminated': [2512, 3787, 3910], 'biologic': [2514, 3912], 'technical': [2516, 3914], 'considerations.': [2517, 3915], '64:': [2523, 3921], '639–52.': [2524, 3922], 'Heggers': [2527, 2534, 3886], 'Variations': [2529], 'theme.': [2532], 'JP,': [2535, 3887], 'Bacteriology:': [2540], 'Its': [2541], 'Armamentarium': [2545], 'Surgeon.': [2548], 'Boca': [2549], 'Raton:': [2550], 'CRC': [2551], 'Press,': [2552], '1991.': [2553], '[TECH]': [2554, 2589, 2607], 'Levine': [2555], 'NS,': [2556], 'Lindberg': [2557], 'RB,': [2558], 'Mason': [2559], 'AD,': [2560], 'Pruitt': [2561], 'smear:': [2568], 'quick,': [2570], 'simple': [2571], 'determining': [2574, 3019], 'number': [2576], 'viable': [2578], 'open': [2582], 'wounds.': [2583], 'Trauma': [2585], '1976;': [2586], '16:': [2587], '89–94.': [2588], 'Nystrom': [2590], 'PO.': [2591], 'microbiological': [2593], 'sampler:': [2595], 'experimental': [2598], 'investigation.': [2599], 'Acta': [2600], 'Pathol': [2601], 'Microbiol': [2602], 'Scand': [2603], '1978;': [2604, 2726, 2951], '86B:': [2605], '361–7.': [2606], 'Volenec': [2608], 'FJ,': [2609], 'Clark': [2610], 'GM,': [2611], 'Mani': [2612], 'MM,': [2613], 'Humphrey': [2614], 'LJ.': [2615], 'Burn': [2616], 'quantitation:': [2620], 'statistical': [2622], 'analysis.': [2623], '1979;': [2627], '138:': [2628], '695–7.': [2629], 'Stephens': [2631], 'Wall': [2633], 'Wilson': [2635], 'MJ,': [2636], 'Hill': [2637, 2641], 'Harding': [2643, 4264], 'Thomas': [2645], 'Anaerobic': [2647], 'cocci': [2648], 'populating': [2649], 'deep': [2651], 'tissues': [2652], 'impair': [2656], 'cellular': [2657, 4015], 'responses': [2660, 4267], 'vitro.': [2662], '148:': [2667], '456–66.': [2668], 'Gerding': [2671], 'DN.': [2672], 'infections': [2674, 2961, 2996, 3134, 3266], 'patients:': [2677], 'anaerobes.': [2681], 'S283–8.': [2689], 'Schraibman': [2692, 2894], 'IG.': [2693, 2895], 'significance': [2695, 2897], 'beta-haemolytic': [2697, 2899], 'R': [2704, 2906], 'Engl': [2707, 2909], '72:': [2709, 2911], '123–4.': [2710], 'Lookingbill': [2713, 2938], 'DP,': [2714, 2939, 3693], 'Miller': [2715, 2940], 'SH,': [2716, 2941], 'RC.': [2718, 2943], 'Bacteriology': [2719, 2944], '114:': [2727, 2952], '1765–8.': [2728, 2953], '#3.3:': [2731], 'For': [2732, 2957], 'following': [2749], 'debridement,': [2751, 4070], 'decrease': [2752, 2801], 'topical': [2758, 2770, 2928], 'antimicrobial': [2759, 2771, 2782, 3075], 'agent.': [2760, 2791], 'Once': [2761], 'balance,': [2764, 4072], 'discontinue': [2765], 'agent': [2772, 2783], 'minimize': [2774], 'possible': [2776], 'cytotoxic': [2777], 'due': [2779, 2998, 3161], 'emergence': [2785], 'resistance': [2788], 'Systemically': [2795], 'administered': [2796], 'antibiotics': [2797, 2969, 2976, 3587], 'do': [2798, 4215], 'effectively': [2800, 3551, 3570], 'granulating': [2805, 2966], 'wounds,': [2806], 'whereas': [2807], 'topically': [2808], 'applied': [2809], 'antimicrobials': [2810, 2854], 'effective.': [2813, 2971], 'infections:': [2818], 'Fumal': [2839], 'Braham': [2841], 'Paquet': [2843], 'Pierard-Franchimont': [2845], 'Pierard': [2847], 'beneficial': [2850], 'toxicity': [2851], 'paradox': [2852], 'impaired': [2859, 4139, 4222], 'polymicrobial': [2862], 'flora:': [2863], 'proof-of-concept': [2865], 'Dermatology': [2867], '204': [2869], '1):': [2871, 3057, 3112, 3657], '70–4.': [2872], 'Mannari': [2876], 'RJ,': [2877, 2916], 'PD,': [2879], 'Payne': [2880], 'WG.': [2881], 'Maintenance': [2882], 'balance.': [2886, 4075], '178:': [2891], '399–402.': [2892], 'streptococcus': [2900], '122–4.': [2912], 'Cooper': [2917, 4233], 'Kingsley': [2919], 'colonization': [2922], 'antimicrobials.': [2929], '563–78.': [2935], '#3.4:': [2956], 'acute': [2958, 2988, 4025], 'confined': [2963], 'wound,': [2967], 'systemic': [2968, 3173, 4106, 4136, 4148, 4158, 4194], 'Systemic': [2975], 'most': [2981, 2994, 3016, 3159, 3569, 4443], 'trials': [2982], 'helpful': [2985, 3017], 'infections.': [2991, 3104, 3289, 3488, 3628, 3649], 'frequent': [2995], 'Gram-positive': [3001, 3174], 'cocci,': [3002], 'Gram-negative': [3004], 'organisms,': [3005], 'organisms': [3008, 3793], 'often': [3010, 3382], 'isolated.': [3011], 'Deep': [3012], 'cultures': [3014], 'antibiotic': [3020, 3099, 3339, 3482, 3555, 3622, 3644, 3705], 'usage.': [3021], 'Consensus': [3026], 'Diagnosing': [3029], 'Treating': [3031], 'Infected': [3033], 'Foot:': [3035], 'international': [3040], 'diagnosing': [3043], 'infected': [3047, 3426, 3530, 3576, 3592], 'foot.': [3049], 'Metab': [3051, 3106, 3651], 'Rev': [3053, 3108, 3653], 'S68-77.': [3058], "O'Meara": [3060], 'Majid': [3064], 'management:': [3073], '(3)': [3074], 'wounds;': [3079], '(4)': [3080], '4:': [3088, 3294, 3834], '1–237.': [3089], 'Berendt': [3093, 3638], 'AR.': [3094, 3639], 'Principles': [3095, 3640], 'therapy': [3100, 3483, 3623, 3645, 3706], '16': [3110, 3655], 'S42–6.': [3113], 'Citron': [3120], 'DM,': [3121, 4234], 'Tice': [3122], 'Morgenstern': [3124], 'Abramson': [3126], 'Ertapenem': [3128], 'versus': [3129], 'piperacillin/tazobactam': [3130], '(SIDESTEP):': [3135], 'prospective,': [3136], 'randomised,': [3137], 'controlled,': [3138], 'double-blinded,': [3139], 'multicentre': [3140], '1695–703.': [3145], '#3.5:': [3148], 'Cellulitis': [3149, 3243], '(inflammation': [3150], 'subcutaneous': [3157, 3202], 'commonly': [3160], 'staphylococci)': [3165], 'surrounding': [3166], 'treated': [3171, 3525, 3552, 3571], 'bactericidal': [3175, 3193], 'antibiotics.': [3176, 3537], 'Edema': [3180], 'fluid': [3181], '(plasma)': [3182], 'neutralizes': [3183], 'fatty': [3185], 'acids': [3186], 'sebum': [3188], 'inactivates': [3190], 'properties': [3194], 'skin.': [3196, 3232, 3269, 3310], 'This': [3197, 4100], 'renders': [3198], 'susceptible': [3204], 'staphylococci.': [3210], 'Rickets': [3212], 'LR,': [3213], 'Squire': [3214], 'JR,': [3215], 'Topley': [3216], 'Human': [3220], 'lipids': [3222], 'particular': [3224], 'reference': [3225], 'self-sterilizing': [3228], 'power': [3229], 'Sci': [3234], 'Mol': [3235], '1951;': [3237], '89–93.': [3239], 'Baddour': [3241], 'LM.': [3242], 'syndromes:': [3244], 'update.': [3246], 'Antimicrob': [3249], 'Agents': [3250, 3973], '113–6.': [3253], 'Chiller': [3256], 'Selkin': [3258], 'Murakawa': [3260], 'GJ.': [3261], 'microflora': [3263], 'Invest': [3271], 'Symp': [3273], 'Proc': [3274], '6:': [3276], '170–4.': [3277], 'Guay': [3280], 'DR.': [3281], 'structure': [3288], 'Expert': [3290], 'Opin': [3291], 'Pharmacother': [3292], '1259–75.': [3295], 'Winters': [3300], 'KL,': [3301], 'Britt': [3302], 'LD,': [3303], 'Long': [3304, 3312], 'Bacterial': [3306, 3870], 'diseases': [3307, 4107, 4177], 'Term': [3313], 'Eff': [3314], 'Implants': [3316], '499–510.': [3319], 'Dall': [3322, 3328], 'Peterson': [3324], 'Simmons': [3326], 'Rapid': [3330], 'resolution': [3331], 'cellulites': [3333], 'managed': [3336], 'combination': [3338], 'anti-inflammatory': [3341, 4313], 'Cutis': [3343], '75:': [3345], '177–80.': [3346], '#3.6:': [3349], 'osteomyelitis': [3351, 3434, 3544, 3566], 'suspected,': 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