Publication Information

{'id': 'https://openalex.org/W1999849224', 'doi': 'https://doi.org/10.1097/qai.0b013e318166498a', 'title': 'Monitoring of HIV-1 Resistance in Tunisia (North Africa) With a Dried Plasma Spot Strategy', 'display_name': 'Monitoring of HIV-1 Resistance in Tunisia (North Africa) With a Dried Plasma Spot Strategy', 'publication_year': 2008, 'publication_date': '2008-04-01', 'ids': {'openalex': 'https://openalex.org/W1999849224', 'doi': 'https://doi.org/10.1097/qai.0b013e318166498a', 'mag': '1999849224', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18332768'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/qai.0b013e318166498a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S157460402', 'display_name': 'JAIDS Journal of Acquired Immune Deficiency Syndromes', 'issn_l': '1525-4135', 'issn': ['1525-4135', '1944-7884'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'letter', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1097/qai.0b013e318166498a', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5108415390', 'display_name': 'Raoudha Dachraoui', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Raoudha Dachraoui', 'raw_affiliation_strings': ["Unité de Virologie, Laboratoire Associé au Centre National de Référence du VIH, EA2656, CHU Charles Nicolle, Rouen, France, †Laboratoire de Microbiologie, Unité de Virologie UR06SP20, CHU Sahloul, Sousse, Tunisie, ‡Service des Maladies Infectieuses de l'Hôpital Fattouma Bourguiba de Monastir, Tunisie, §Service des Maladies Infectieuses de l'Hôpital Farhat Hached de Sousse, Sousse, Tunisie, ¶Service de Microbiologie, Hôpital Saint-Louis, AP-HP, Paris, France"], 'affiliations': [{'raw_affiliation_string': "Unité de Virologie, Laboratoire Associé au Centre National de Référence du VIH, EA2656, CHU Charles Nicolle, Rouen, France, †Laboratoire de Microbiologie, Unité de Virologie UR06SP20, CHU Sahloul, Sousse, Tunisie, ‡Service des Maladies Infectieuses de l'Hôpital Fattouma Bourguiba de Monastir, Tunisie, §Service des Maladies Infectieuses de l'Hôpital Farhat Hached de Sousse, Sousse, Tunisie, ¶Service de Microbiologie, Hôpital Saint-Louis, AP-HP, Paris, France", 'institution_ids': ['https://openalex.org/I4210097159']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111693208', 'display_name': 'Agnès Depatureaux', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210097159', 'display_name': 'Assistance Publique – Hôpitaux de Paris', 'ror': 'https://ror.org/00pg5jh14', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210097159']}], 'countries': ['FR'], 'is_corresponding': True, 'raw_author_name': 'Agnès Depatureaux', 'raw_affiliation_strings': ["Unité de Virologie, Laboratoire Associé au Centre National de Référence du VIH, EA2656, CHU Charles Nicolle, Rouen, France, †Laboratoire de Microbiologie, Unité de Virologie UR06SP20, CHU Sahloul, Sousse, Tunisie, ‡Service des Maladies Infectieuses de l'Hôpital Fattouma Bourguiba de Monastir, Tunisie, §Service des Maladies Infectieuses de l'Hôpital Farhat Hached de Sousse, Sousse, Tunisie, ¶Service de Microbiologie, Hôpital Saint-Louis, AP-HP, Paris, France"], 'affiliations': [{'raw_affiliation_string': "Unité de Virologie, Laboratoire Associé au Centre National de Référence du VIH, EA2656, CHU Charles Nicolle, Rouen, France, †Laboratoire de Microbiologie, Unité de Virologie UR06SP20, CHU Sahloul, Sousse, Tunisie, ‡Service des Maladies Infectieuses de l'Hôpital Fattouma Bourguiba de Monastir, Tunisie, §Service des Maladies Infectieuses de l'Hôpital Farhat Hached de Sousse, Sousse, Tunisie, ¶Service de Microbiologie, Hôpital Saint-Louis, AP-HP, Paris, France", 'institution_ids': ['https://openalex.org/I4210097159']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103061414', 'display_name': 'M. 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'https://openalex.org/W2141954010', 'https://openalex.org/W2147381856', 'https://openalex.org/W2318943952', 'https://openalex.org/W4233896864', 'https://openalex.org/W4294294185'], 'related_works': ['https://openalex.org/W4206063734', 'https://openalex.org/W4200374162', 'https://openalex.org/W2414455566', 'https://openalex.org/W2102232203', 'https://openalex.org/W2039159829', 'https://openalex.org/W2031465040', 'https://openalex.org/W1986766699', 'https://openalex.org/W1578252921', 'https://openalex.org/W1491530856', 'https://openalex.org/W113603868'], 'abstract_inverted_index': {'To': [0], 'the': [1, 10, 40, 51, 67, 74, 86, 119, 130, 152, 199, 202, 205, 209, 359, 416, 419, 422, 428, 454, 466, 470, 503, 530, 537, 553, 559, 579, 583, 688, 780, 814, 833, 842, 846, 870, 877, 887, 901, 908, 921, 951, 982, 1004, 1017, 1030, 1047, 1060, 1073, 1086, 1095, 1110, 1163, 1178, 1206, 1213, 1220, 1227, 1238, 1253, 1324, 1335, 1373, 1378, 1385, 1388, 1414, 1418, 1421, 1447, 1450, 1460, 1476, 1488, 1516, 1520, 1582, 1594, 1628, 1632, 1639, 1658, 1665, 1684, 1697, 1700, 1714, 1719, 1731, 1752, 1769, 1777, 1780, 1784, 1789], 'Editor:': [2], 'The': [3, 24, 774, 800, 808, 829, 848, 929, 975, 1366, 1407, 1619, 1680, 1766], 'HIV-1': [4, 219, 337], 'epidemic': [5], 'is': [6, 61, 105, 1344, 1511, 1539, 1625], 'particularly': [7], 'severe': [8], 'in': [9, 45, 73, 85, 108, 116, 173, 191, 220, 239, 328, 389, 424, 437, 597, 629, 749, 805, 884, 912, 957, 1010, 1022, 1036, 1065, 1078, 1119, 1144, 1154, 1177, 1215, 1219, 1237, 1309, 1314, 1334, 1340, 1350, 1429, 1479, 1512, 1579, 1607, 1664, 1672, 1683, 1718, 1740, 1758, 1774, 1783], 'resource-limited': [11, 75, 109, 1336, 1666, 1685], 'countries,': [12], 'where': [13], 'more': [14, 87, 271, 1341, 1673, 1715], 'than': [15, 272], '30': [16, 643, 657, 661, 717, 722, 726, 731], 'million': [17], 'people': [18], 'are': [19, 803, 1563, 1605], 'living': [20], 'with': [21, 201, 258, 334, 393, 474, 478, 706, 754, 779, 841, 898, 907, 941, 969, 993, 1049, 1113, 1134, 1137, 1147, 1157, 1184, 1193, 1212, 1232, 1301, 1397, 1433, 1472, 1508, 1610, 1627, 1730, 1761], 'HIV': [22, 56, 147, 1756], 'infection.1': [23], 'expansion': [25], 'of': [26, 43, 50, 55, 70, 118, 123, 132, 146, 154, 243, 349, 352, 361, 396, 408, 418, 446, 453, 468, 497, 517, 558, 567, 578, 605, 609, 621, 654, 697, 719, 832, 853, 886, 890, 900, 910, 947, 959, 977, 984, 1013, 1015, 1025, 1027, 1039, 1041, 1068, 1070, 1081, 1083, 1094, 1109, 1162, 1174, 1208, 1229, 1235, 1289, 1327, 1387, 1417, 1452, 1459, 1465, 1490, 1494, 1502, 1526, 1546, 1581, 1590, 1593, 1596, 1621, 1631, 1641, 1650, 1654, 1660, 1699, 1721, 1755, 1779, 1787], 'access': [27], 'to': [28, 35, 58, 207, 230, 236, 245, 270, 379, 401, 433, 513, 551, 812, 1383, 1443, 1497, 1504, 1554, 1565, 1670, 1691, 1706, 1710, 1713, 1750], 'antiretroviral': [29, 59, 246, 290, 1434], 'drugs': [30, 60, 72], 'has': [31, 79], 'made': [32], 'it': [33, 1704, 1745], 'necessary': [34, 987], 'develop': [36], 'appropriate': [37], 'tools': [38, 1733], 'for': [39, 66, 82, 141, 164, 186, 218, 241, 381, 508, 524, 642, 647, 656, 660, 665, 675, 687, 714, 721, 725, 730, 740, 857, 863, 926, 981, 988, 1197, 1292, 1323, 1402, 1438, 1475, 1542, 1574, 1643, 1646, 1678, 1734, 1747, 1797], 'therapeutic': [41, 1325, 1491, 1647, 1753], 'follow-up': [42, 1648], 'patients': [44, 216, 257, 283, 299, 855, 914, 1120, 1145, 1155, 1165, 1291, 1304, 1311, 1356, 1437, 1486], 'these': [46, 71], 'regions.': [47], 'Epidemiologic': [48], 'surveillance': [49], 'spread': [52], 'and': [53, 96, 121, 143, 175, 204, 232, 296, 315, 319, 323, 399, 415, 450, 520, 555, 569, 615, 618, 645, 663, 668, 690, 693, 703, 728, 733, 760, 768, 817, 850, 859, 861, 875, 917, 931, 950, 998, 1029, 1054, 1072, 1140, 1150, 1170, 1180, 1203, 1226, 1265, 1312, 1338, 1346, 1375, 1420, 1445, 1529, 1533, 1548, 1550, 1556, 1592, 1649, 1668, 1709, 1736, 1793], 'transmission': [54], 'resistant': [57], 'also': [62, 112, 588, 1688], 'a': [63, 93, 101, 156, 170, 183, 189, 259, 394, 434, 460, 479, 485, 515, 598, 630, 669, 734, 750, 942, 978, 994, 1050, 1185, 1411, 1456, 1499, 1692, 1723], 'major': [64], 'issue': [65], 'future': [68], 'use': [69, 99, 976, 1659, 1698], 'countries.': [76, 110], 'Resistance': [77, 448, 758], 'genotyping': [78, 759], 'proved': [80], 'useful': [81, 171], 'such': [83, 1722], 'monitoring': [84, 187, 1326], 'developed': [88, 1342, 1674, 1716], 'countries.2': [89], 'This': [90, 1725], 'method': [91, 140, 163, 1702], 'requires': [92], 'sequencer,': [94], 'however,': [95], 'its': [97, 1391], 'routine': [98], 'outside': [100], 'few': [102], 'reference': [103, 824, 872, 1694, 1763], 'centers': [104, 360], 'therefore': [106], 'difficult': [107, 1564], 'It': [111], 'poses': [113], 'logistic': [114], 'problems': [115], 'terms': [117], 'transport': [120], 'storage': [122], 'plasma': [124, 158, 193, 251, 260, 304, 354, 825, 836, 873, 964], 'samples.': [125], 'Many': [126], 'studies': [127, 1589], 'have': [128, 1358], 'demonstrated': [129, 151, 1487], 'utility': [131], 'dried': [133, 157], 'sample': [134, 355, 413, 420, 965, 1222, 1240, 1370], 'spot': [135, 161, 476, 980, 1102], 'technology': [136], 'as': [137, 462, 534, 562, 590, 636, 684, 709, 771, 827, 1393, 1616], 'an': [138, 335, 1172, 1233], 'alternative': [139, 172], 'serologic': [142, 1732], 'molecular': [144, 1543, 1570, 1587, 1651], 'analyses': [145, 1653], 'infection.3-7': [148], 'We': [149, 248, 1567], 'recently': [150], 'feasibility': [153, 1489, 1640], 'using': [155, 484, 694, 1530], 'spot/dried': [159], 'serum': [160], '(DPS/DSS)': [162], 'resistance': [165, 244, 775, 1175, 1209, 1328, 1415, 1425, 1549, 1644], 'genotyping,': [166], 'which': [167, 192, 438, 1468], 'could': [168, 838, 865, 1347, 1687], 'be': [169, 839, 867, 1348, 1552, 1689], 'clinical': [174], 'epidemiologic': [176, 1544, 1652], 'settings.8': [177], 'In': [178, 465, 1126, 1160, 1195, 1436, 1634], 'this': [179, 927, 1321, 1775], 'study,': [180], 'we': [181, 1440, 1454, 1636], 'tested': [182], 'sequencing-based': [184], 'strategy': [185, 1322], 'from': [188, 198, 215, 253, 265, 282, 297, 459, 869, 876, 892, 937, 1092, 1100, 1355, 1484], 'distance,': [190], 'samples': [194, 212, 223, 252, 305, 330, 430, 826, 837, 891, 903, 940, 992, 1048, 1332, 1354, 1482, 1662, 1681, 1708], 'were': [195, 213, 224, 280, 306, 377, 431, 440, 626, 745, 763, 777, 820, 882, 934, 1200, 1295, 1427, 1441], 'collected': [196, 281, 307, 1682], 'far': [197], 'center': [200], 'sequencer': [203], 'expertise': [206], 'interpret': [208], 'results.': [210], 'Blood': [211], 'taken': [214, 1483], 'positive': [217], 'Tunisia.': [221], 'Plasma': [222], 'deposited': [225, 501, 1518, 1663], 'on': [226, 365, 822, 1252, 1330, 1353, 1372, 1519, 1657], 'filter': [227, 367, 1374, 1521], 'paper,': [228], 'allowed': [229], 'dry,': [231], 'sent': [233, 1669, 1690], 'by': [234, 522, 536, 651, 747, 766, 1244, 1249, 1395, 1514, 1676], 'post': [235, 1677], 'our': [237, 970, 1398, 1495], 'laboratory': [238, 423, 1379, 1770], 'France': [240, 402, 1844, 1881], 'analysis': [242, 1251, 1642], 'drugs.': [247, 1435], 'obtained': [249, 802, 897, 1333], '33': [250, 455, 834], '24': [254, 1583], 'HIV-1-infected': [255], 'Tunisian': [256, 1785], 'viral': [261], 'load': [262], '(VL)': [263], 'ranging': [264], '1300': [266], 'copies/mL': [267, 274], '(3.1': [268], 'log)': [269, 276, 1189], '750,000': [273], '(5.9': [275], '(Table': [277], '1).': [278, 974, 1045, 1105], 'Samples': [279], 'who': [284, 1121, 1357, 1772], 'had': [285, 1122], 'never': [286, 1123, 1359, 1431], 'received': [287], 'highly': [288, 1534, 1540], 'active': [289], 'treatment': [291, 309, 321, 1135], '(HAART)': [292], '(n': [293, 300, 1001, 1057, 1286], '=': [294, 301, 1002, 1058, 1260, 1270, 1276, 1287], '13)': [295], 'treated': [298, 1127, 1146, 1156, 1164, 1361, 1432, 1485], '5).': [302], 'Serial': [303], 'during': [308, 320, 1204], '(patient': [310], '[P]': [311], '5,': [312], 'P15,': [313], 'P18,': [314], 'P22)': [316], 'or': [317, 1267, 1272, 1362, 1390, 1562], 'before': [318, 345, 1202], '(P6': [322], 'P8).': [324], 'VL': [325, 943, 995, 1051, 1187, 1236], 'was': [326, 356, 457, 472, 500, 549, 587, 595, 682, 896, 923, 954, 966, 986, 1007, 1019, 1033, 1063, 1076, 1089, 1117, 1217, 1469, 1572], 'measured': [327], 'native': [329, 823, 835, 871, 963], '(stored': [331], 'at': [332, 384, 403, 421, 511, 527, 640, 673, 712, 738, 1377, 1405, 1575], '−80°C)': [333], 'Amplicor': [336], 'Monitor': [338], '(version': [339], '1.5;': [340], 'Roche': [341], 'Diagnostics,': [342], 'Meylan,': [343], 'France)': [344, 633], 'spotting.': [346], 'A': [347, 406, 539, 575, 678, 1106], 'total': [348], '20': [350, 607, 695, 960, 1288, 1527], 'μL': [351, 496, 620, 1524], 'each': [353, 610], 'spotted': [357], 'onto': [358], '6': [362], 'circles': [363], 'drawn': [364], 'S&S903': [366], 'paper': [368, 1522], '(Schleicher': [369], '&': [370], 'Schuell,': [371], 'BioScience/Whatman,': [372], 'GmbH,': [373], 'Dassel,': [374], 'Germany).': [375], 'Filters': [376], 'left': [378], 'dry': [380], '1': [382, 619, 638, 1315, 1577], 'hour': [383], 'room': [385, 404], 'temperature,': [386], 'placed': [387], 'individually': [388], 'small': [390], 'plastic': [391], 'bags': [392], 'sachet': [395], 'desiccant,': [397], 'stored,': [398], 'mailed': [400], 'temperature.': [405], 'period': [407, 1368], '9': [409], 'days': [410, 1404], 'elapsed': [411], 'between': [412, 1369, 1413], 'collection': [414], 'arrival': [417], 'Rouen.': [425], 'On': [426], 'arrival,': [427], 'DPS': [429, 879, 939, 1331, 1661, 1701], 'transferred': [432], '−80°C': [435], 'freezer,': [436], 'they': [439], 'stored': [441], 'until': [442], 'testing.TABLE': [443], '1:': [444], 'Results': [445], 'Amplification,': [447], 'Genotyping,': [449], 'Genetic': [451], 'Subtyping': [452, 1248], 'SamplesRNA': [456], 'extracted': [458], 'DPS,': [461], 'previously': [463, 563, 685, 772, 1617], 'described.8': [464, 773], 'absence': [467, 1173, 1228, 1620, 1720], 'amplification,': [469], 'extraction': [471, 1531], 'repeated': [473], 'another': [475, 1101], 'but': [477, 1696], 'supplementary': [480], '10-fold': [481], 'concentration': [482], 'step,': [483], 'Microcon': [486, 504, 531], 'YM-50': [487, 505, 532], 'device': [488], '(Millipore,': [489], 'Saint-Quentin': [490], 'en': [491], 'Yvelines,': [492], 'France);': [493], 'briefly,': [494], '100': [495], 'RNA': [498, 592], 'eluate': [499], 'into': [502], 'device,': [506, 533], 'centrifuged': [507], '2': [509, 603, 648, 899, 989, 1262, 1310, 1611], 'minutes': [510, 526, 644, 742], '14,000g': [512], 'obtain': [514], 'concentrate': [516], '10': [518], 'μL,': [519], 'recovered': [521], 'centrifugation': [523], '3': [525, 854, 902, 913, 1273, 1303], '1000g': [528], 'turning': [529], 'recommended': [535], 'manufacturer.': [538], 'nested': [540, 679], 'reverse': [541], 'transcriptase': [542], '(RT)': [543], 'polymerase': [544], 'chain': [545], 'reaction': [546, 600], '(PCR)': [547], 'assay': [548, 681], 'used': [550, 811, 1349], 'amplify': [552, 813, 1444], 'protease': [554, 691, 830, 930, 1005, 1061, 1111, 1181, 1266], 'RT': [556, 689, 849, 858, 932, 1031, 1087, 1179], 'regions': [557, 819, 852, 933, 1075, 1182, 1263, 1557], 'pol': [560], 'gene,': [561, 1112, 1578], 'described,': [564], 'yielding': [565], 'fragments': [566], '507': [568], '798': [570], 'base': [571], 'pairs': [572], '(bp),': [573], 'respectively.8': [574], '655-bp': [576], 'fragment': [577], 'gp41': [580, 698, 818, 851, 888, 911, 952, 985, 1018, 1074, 1448], 'region': [581, 831, 889, 953, 1006, 1032, 1062, 1088, 1257], 'encompassing': [582], 'enfuvirtide': [584], '(T20)': [585], 'target': [586, 1451], 'amplified,': [589], 'follows:': [591, 637, 710], '(10': [593], 'μL)': [594, 1528], 'amplified': [596, 840, 868, 936, 956, 968, 1009, 1021, 1035, 1064, 1077, 1091, 1296], '50-μL': [599], 'mixture': [601], 'containing': [602], 'mM': [604], 'MgSO4,': [606], 'pmol': [608, 696], 'outer': [611], 'primer': [612], '(1S': [613], 'TGGAGGAGGAGATATGAGG': [614], 'AS1': [616], 'GTGAGTATCCCTGCCTAACTCTAT),': [617], 'RT/platinum': [622], 'Taq.': [623], 'Amplification': [624, 743], 'reactions': [625], 'carried': [627, 764], 'out': [628, 765], 'Perkin-Elmer': [631], '(Courtaboeuf,': [632], '2400': [634], 'thermocycler': [635], 'cycle': [639], '50°C': [641], '94°C': [646, 655, 720], 'minutes;': [649, 716], 'followed': [650], '35': [652], 'cycles': [653, 718], 'seconds,': [658, 662, 723, 727], '55°C': [659, 724], '68°C': [664], '60': [666], 'seconds;': [667, 732], 'final': [670, 735], 'extension': [671, 736], 'step': [672, 737], '72°C': [674, 729, 739], '7': [676, 741], 'minutes.': [677], 'PCR': [680, 922], 'performed,': [683], 'described': [686], 'fragments,8': [692], 'inner': [699], 'primers': [700], '(T20S1': [701], 'GAGGGACAATTGGAGAAGTGAATT': [702], '2AS': [704], 'CTACCAAGCCTCCTACTATC)': [705], 'amplification': [707, 885, 895, 909, 983], 'conditions': [708, 1352], 'heating': [711], '95°C': [713], '15': [715], 'products': [744], 'visualized': [746], 'electrophoresis': [748], '1%': [751], 'agarose': [752], 'gel,': [753], 'ethidium': [755], 'bromide': [756], 'staining.': [757], 'genetic': [761], 'subtyping': [762], 'sequencing': [767, 1129, 1408], 'phylogenetic': [769, 1250], 'analysis,': [770], 'mutations': [776, 1142, 1152, 1176, 1230, 1426, 1645], 'interpreted': [778], 'Agence': [781], 'Nationale': [782], 'de': [783, 1828, 1835, 1846, 1849, 1875], 'Recherches': [784], 'sur': [785], 'le': [786], 'Sida': [787], 'et': [788], 'les': [789], 'Hépatites': [790], 'Virales': [791], '(ANRS)': [792], 'algorithm': [793], '(July': [794], '2006': [795], 'version;': [796], 'available': [797, 1201, 1254], 'at:': [798], 'http://www.hivfrenchresistance.org/).': [799], 'results': [801, 1318, 1400, 1409, 1600], 'presented': [804], 'Table': [806, 973, 1044, 1104, 1224, 1279, 1299], '1.': [807], 'RT-PCR': [809], 'techniques': [810], 'protease,': [815], 'RT,': [816], 'validated': [821], 'controls.': [828], 'protocol': [843], 'used,': [844], 'whatever': [845], 'VL.': [847], '(P31': [856], 'P21': [860], 'P27': [862], 'gp41)': [864], 'not': [866, 967, 1090, 1381], 'sample,': [874], 'corresponding': [878], 'sample.': [880], 'Difficulties': [881], 'encountered': [883], 'P8:': [893], 'no': [894, 1114, 1473], 'available.': [904], 'These': [905], 'difficulties': [906], '(P8,': [915], 'P21,': [916], 'P27)': [918], 'suggest': [919], 'that': [920, 1282, 1320, 1558, 1569, 1602], 'less': [924], 'robust': [925], 'fragment.': [928], 'successfully': [935, 955, 1008, 1020, 1034], 'all': [938], '≥5': [944], 'log': [945, 997, 1000, 1053, 1056], '(21': [946], '21': [948], 'samples),': [949], '19': [958, 1466], 'cases': [961, 1042, 1071], '(1': [962, 1080, 1256], 'protocol;': [971], 'see': [972, 1278, 1298], 'second': [979, 1221], 'patients.': [990], 'For': [991, 1046], '≥4': [996], '<5': [999], '6),': [1003, 1059], '100%': [1011], '(6': [1012], '6)': [1014, 1040, 1069, 1082], 'cases,': [1016, 1028, 1084], '75%': [1023], '(3': [1024, 1067], '4)': [1026], '67%': [1037], '(4': [1038], '(see': [1043, 1103, 1223], '≥3': [1052], '<4': [1055], '50%': [1066], '17%': [1079], 'whereas': [1085], 'any': [1093], 'samples,': [1096], 'even': [1097], 'after': [1098], 're-extraction': [1099], 'natural': [1107], 'polymorphism': [1108], 'primary': [1115], 'mutations,': [1116, 1210], 'identified': [1118, 1143], 'been': [1124, 1360], 'treated.': [1125], 'patients,': [1128, 1584], 'revealed': [1130, 1410], 'mutation': [1131, 1462], 'profiles': [1132], 'consistent': [1133, 1626], 'status,': [1136], 'L100I,': [1138], 'K103N,': [1139], 'Y188L': [1141], 'efavirenz': [1148], '(EFV)': [1149], 'M184V': [1151], 'found': [1153, 1455, 1568], 'lamivudine': [1158], '(3TC).': [1159], '5': [1161], '[P5,': [1166], 'P8,': [1167, 1196], 'P13,': [1168], 'P15(1),': [1169], 'P19],': [1171], 'associated': [1183, 1231], 'high': [1186, 1457], '(>5': [1188], 'suggesting': [1190], 'poor': [1191, 1242, 1748], 'compliance': [1192, 1243], 'treatment.': [1194, 1247], 'whom': [1198, 1293, 1439], 'sequences': [1199, 1255, 1294], 'treatment,': [1205, 1216], 'appearance': [1207], 'correlated': [1211], 'change': [1214], 'observed': [1218], '1),': [1225, 1300], 'increase': [1234], 'third': [1239], 'indicates': [1241], 'likely': [1245], 'stopping': [1246], '[protease],': [1258], 'n': [1259, 1269, 1275], '2;': [1261], '[RT': [1264], 'gp41],': [1268], '3;': [1271], 'regions,': [1274], '18;': [1277], '1)': [1280], 'showed': [1281], 'B-subtype': [1283, 1603], 'viruses': [1284, 1307, 1604], 'predominated': [1285], '23': [1290, 1580], '[87%];': [1297], 'only': [1302], 'having': [1305], 'non-B-subtype': [1306], '(CRF02_AG': [1308], 'CRF13_cpx': [1313], 'patient).': [1316], 'Our': [1317, 1537, 1599], 'indicate': [1319], 'based': [1329, 1656], 'countries': [1337, 1343, 1667, 1675, 1686, 1717, 1749], 'analyzed': [1339], 'feasible': [1345], 'field': [1351], 'displayed': [1363], 'ARV': [1364], 'escape.': [1365], '9-day': [1367], 'deposition': [1371], 'reception': [1376], 'did': [1380], 'seem': [1382], 'affect': [1384], 'stability': [1386], 'virus': [1389], 'RNA,': [1392], 'shown': [1394], 'comparison': [1396], 'previous': [1399], '(storage': [1401], '14': [1403], '4°C).8': [1406], 'correlation': [1412], 'status': [1416], 'patient': [1419], 'treatments': [1422], 'used.': [1423], 'No': [1424], 'detected': [1428], 'populations': [1430, 1555], 'able': [1442], 'sequence': [1446], 'region,': [1449], 'T20,': [1453], 'frequency': [1458], 'N42S': [1461], '(5': [1463], '[26%]': [1464], 'patients),': [1467], 'naturally': [1470], 'present,': [1471], 'implications': [1474], 'algorithms': [1477], 'currently': [1478, 1739], 'use.': [1480], 'Sequential': [1481], 'follow-up.': [1492], 'Optimization': [1493], 'technique': [1496, 1538], 'achieve': [1498], 'detection': [1500], 'threshold': [1501], '1000': [1503], '5000': [1505], 'copies/mL,': [1506], 'compatible': [1507], 'individual': [1509], 'follow-up,': [1510], 'progress': [1513], 'increasing': [1515], 'volume': [1517], '(50': [1523], 'instead': [1525], 'kits': [1532], 'sensitive': [1535], 'enzymes.': [1536], 'suitable': [1541], 'surveys': [1545], 'diversity': [1547, 1591, 1655], 'may': [1551], 'applied': [1553], 'cover': [1559], 'large': [1560], 'areas': [1561], 'reach.': [1566], 'typing': [1571], 'possible,': [1573], 'least': [1576], 'making': [1585], 'possible': [1586, 1705, 1746], 'epidemiology': [1588], 'emergence': [1595], 'mosaic': [1597, 1623], 'forms.': [1598], 'show': [1601], 'circulating': [1606, 1612], 'Tunisia,': [1608], 'together': [1609], 'recombinant': [1613], 'forms': [1614, 1624], '(CRFs),': [1615], 'observed.9': [1618], 'complex': [1622], 'recent': [1629], 'nature': [1630], 'epidemic.': [1633], 'conclusion,': [1635], 'demonstrate': [1637], 'here': [1638], 'laboratories': [1671], 'analysis.': [1679], 'local': [1693], 'center,': [1695], 'makes': [1703], 'store': [1707], 'send': [1711], 'them': [1712], 'center.': [1724], 'technologic': [1726], 'simplification,': [1727], 'if': [1728], 'combined': [1729], 'diagnosis': [1735], 'quantification': [1737], 'methods': [1738], 'place': [1741], 'locally,': [1742], 'would': [1743], 'make': [1744], 'improve': [1751], 'management': [1754], 'infection': [1757], 'close': [1759], 'collaboration': [1760], 'regional': [1762], 'centers.': [1764], 'ACKNOWLEDGMENTS': [1765], 'authors': [1767], 'thank': [1768], 'technicians': [1771], 'participated': [1773], 'work,': [1776], 'direction': [1778], 'basic': [1781], 'health': [1782], 'Ministry': [1786], 'Health,': [1788], 'ANRS': [1790], '(Paris,': [1791], 'France),': [1792], 'Rouen': [1794], 'University': [1795], 'Hospital': [1796], 'financial': [1798], 'support.': [1799], 'Raoudha': [1800], 'Dachraoui,': [1801], 'PharmD*†': [1802], 'Agnès': [1803], 'Depatureaux,': [1804], 'MD*': [1805], 'Mohamed': [1806], 'Chakroun,': [1807], 'MD‡': [1808], 'Imène': [1809], 'Fodha,': [1810], 'PharmD,': [1811, 1825], 'PhD†': [1812], 'Amel': [1813], 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[1880]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1999849224', 'counts_by_year': [{'year': 2021, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2025-01-10T16:30:46.425497', 'created_date': '2016-06-24'}