Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1999777294', 'doi': 'https://doi.org/10.1002/art.20568', 'title': 'Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial', 'display_name': 'Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial', 'publication_year': 2004, 'publication_date': '2004-11-01', 'ids': {'openalex': 'https://openalex.org/W1999777294', 'doi': 'https://doi.org/10.1002/art.20568', 'mag': '1999777294', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15529377'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/art.20568', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132787887', 'display_name': 'Arthritis & Rheumatism', 'issn_l': '0004-3591', 'issn': ['0004-3591', '1529-0131'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': 'https://doi.org/10.1002/art.20568', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5013156684', 'display_name': 'E. William St. Clair', 'orcid': 'https://orcid.org/0000-0003-1181-0650'}, 'institutions': [{'id': 'https://openalex.org/I4210126298', 'display_name': 'Duke Medical Center', 'ror': 'https://ror.org/03njmea73', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210126298', 'https://openalex.org/I4210144876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E. William St. Clair', 'raw_affiliation_strings': ['Duke University Medical Center, Durham, North Carolina, USA.'], 'affiliations': [{'raw_affiliation_string': 'Duke University Medical Center, Durham, North Carolina, USA.', 'institution_ids': ['https://openalex.org/I4210126298']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104506506', 'display_name': 'Désirée van der Heijde', 'orcid': 'https://orcid.org/0000-0002-5781-158X'}, 'institutions': [{'id': 'https://openalex.org/I2800191616', 'display_name': 'Maastricht University Medical Centre', 'ror': 'https://ror.org/02d9ce178', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800191616']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Désirée M. F. M. van der Heijde', 'raw_affiliation_strings': ['University Hospital Maastricht, Maastricht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'University Hospital Maastricht, Maastricht, The Netherlands', 'institution_ids': ['https://openalex.org/I2800191616']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090753435', 'display_name': 'Josef S Smolen', 'orcid': 'https://orcid.org/0000-0002-4302-8877'}, 'institutions': [{'id': 'https://openalex.org/I76134821', 'display_name': 'Medical University of Vienna', 'ror': 'https://ror.org/05n3x4p02', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I76134821']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Josef S. Smolen', 'raw_affiliation_strings': ['\xa0Medical University of Vienna, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': '\xa0Medical University of Vienna, Vienna, Austria', 'institution_ids': ['https://openalex.org/I76134821']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111772241', 'display_name': 'Ravinder N. Maini', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210126716', 'display_name': 'British Society for Rheumatology', 'ror': 'https://ror.org/02dj61c35', 'country_code': 'GB', 'type': 'other', 'lineage': ['https://openalex.org/I4210126716']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Ravinder N. Maini', 'raw_affiliation_strings': ['Kennedy Institute of Rheumatology, London, UK'], 'affiliations': [{'raw_affiliation_string': 'Kennedy Institute of Rheumatology, London, UK', 'institution_ids': ['https://openalex.org/I4210126716']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042617054', 'display_name': 'Joan M. Bathon', 'orcid': 'https://orcid.org/0000-0001-6811-8986'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joan M. Bathon', 'raw_affiliation_strings': ['Johns Hopkins University,Baltimore,Maryland'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University,Baltimore,Maryland', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018678002', 'display_name': 'Paul Emery', 'orcid': 'https://orcid.org/0000-0002-7429-8482'}, 'institutions': [{'id': 'https://openalex.org/I130828816', 'display_name': 'University of Leeds', 'ror': 'https://ror.org/024mrxd33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I130828816']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Paul Emery', 'raw_affiliation_strings': ['University of Leeds, Leeds, UK'], 'affiliations': [{'raw_affiliation_string': 'University of Leeds, Leeds, UK', 'institution_ids': ['https://openalex.org/I130828816']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080646462', 'display_name': 'Edward Keystone', 'orcid': 'https://orcid.org/0000-0001-6606-0071'}, 'institutions': [{'id': 'https://openalex.org/I1324220072', 'display_name': 'Mount Sinai Hospital', 'ror': 'https://ror.org/01zkyz108', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1320796813', 'https://openalex.org/I1324220072']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Edward Keystone', 'raw_affiliation_strings': ['Center for Advanced Therapeutics, Mt. Sinai Hospital, Toronto, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'Center for Advanced Therapeutics, Mt. Sinai Hospital, Toronto, Ontario, Canada', 'institution_ids': ['https://openalex.org/I1324220072']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047233668', 'display_name': 'Michael Schiff', 'orcid': 'https://orcid.org/0000-0001-9814-363X'}, 'institutions': [{'id': 'https://openalex.org/I4210133818', 'display_name': 'Denver Arthritis Clinic', 'ror': 'https://ror.org/047v0da79', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210133818']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael Schiff', 'raw_affiliation_strings': ['Denver Arthritis Clinic, Denver, Colorado'], 'affiliations': [{'raw_affiliation_string': 'Denver Arthritis Clinic, Denver, Colorado', 'institution_ids': ['https://openalex.org/I4210133818']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111538700', 'display_name': 'Joachim R. Kalden', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145647', 'display_name': 'Fraunhofer Institute for Cell Therapy and Immunology', 'ror': 'https://ror.org/04x45f476', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210145647', 'https://openalex.org/I4923324']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Joachim R. Kalden', 'raw_affiliation_strings': ['Institute for Clinical Immunology, Erlangen, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute for Clinical Immunology, Erlangen, Germany', 'institution_ids': ['https://openalex.org/I4210145647']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100341634', 'display_name': 'Ben Wang', 'orcid': 'https://orcid.org/0000-0002-4134-1835'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ben Wang', 'raw_affiliation_strings': ['Centocor, Inc., Malvern, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Centocor, Inc., Malvern, Pennsylvania', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087576743', 'display_name': 'Kimberly L. DeWoody', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kimberly DeWoody', 'raw_affiliation_strings': ['Centocor, Inc., Malvern, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Centocor, Inc., Malvern, Pennsylvania', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025844567', 'display_name': 'Roberta Weiss', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roberta Weiss', 'raw_affiliation_strings': ['Centocor, Inc., Malvern, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Centocor, Inc., Malvern, Pennsylvania', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5107500715', 'display_name': 'Daniel L. Baker', 'orcid': 'https://orcid.org/0000-0003-1482-0416'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel Baker', 'raw_affiliation_strings': ['Centocor, Inc., Malvern, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Centocor, Inc., Malvern, Pennsylvania', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 5, 'institutions_distinct_count': 9, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 53.621, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1165, 'citation_normalized_percentile': {'value': 0.999847, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '50', 'issue': '11', 'first_page': '3432', 'last_page': '3443'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10200', 'display_name': 'Rheumatoid Arthritis Research and Therapies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11157', 'display_name': 'Chronic Lymphocytic Leukemia Research', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11616', 'display_name': 'Autoimmune and Inflammatory Disorders Research', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2777138892', 'wikidata': 'https://www.wikidata.org/wiki/Q415264', 'display_name': 'Infliximab', 'level': 3, 'score': 0.96992934}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8889278}, {'id': 'https://openalex.org/C2777575956', 'wikidata': 'https://www.wikidata.org/wiki/Q187255', 'display_name': 'Rheumatoid arthritis', 'level': 2, 'score': 0.8148279}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.7918241}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.68102926}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6371498}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.6001124}, {'id': 'https://openalex.org/C2777077863', 'wikidata': 'https://www.wikidata.org/wiki/Q170990', 'display_name': 'Arthritis', 'level': 2, 'score': 0.497093}, {'id': 'https://openalex.org/C198451711', 'wikidata': 'https://www.wikidata.org/wiki/Q327657', 'display_name': 'Rheumatology', 'level': 2, 'score': 0.45900628}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.38162887}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.31935102}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.05995074}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018501', 'descriptor_name': 'Antirheumatic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000000981', 'qualifier_name': 'diagnostic imaging', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D001172', 'descriptor_name': 'Arthritis, Rheumatoid', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D001175', 'descriptor_name': 'Arthrography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015551', 'descriptor_name': 'Autoimmunity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004359', 'descriptor_name': 'Drug Therapy, Combination', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069285', 'descriptor_name': 'Infliximab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010352', 'descriptor_name': 'Patient Dropouts', 'qualifier_ui': 'Q000706', 'qualifier_name': 'statistics & numerical data', 'is_major_topic': False}, {'descriptor_ui': 'D010352', 'descriptor_name': 'Patient Dropouts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020127', 'descriptor_name': 'Recovery of Function', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/art.20568', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132787887', 'display_name': 'Arthritis & Rheumatism', 'issn_l': '0004-3591', 'issn': ['0004-3591', '1529-0131'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15529377', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/art.20568', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132787887', 'display_name': 'Arthritis & Rheumatism', 'issn_l': '0004-3591', 'issn': ['0004-3591', '1529-0131'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1492940207', 'https://openalex.org/W1596381381', 'https://openalex.org/W1597379943', 'https://openalex.org/W1775415256', 'https://openalex.org/W1979364075', 'https://openalex.org/W1982348705', 'https://openalex.org/W1985004174', 'https://openalex.org/W1985763670', 'https://openalex.org/W1996472975', 'https://openalex.org/W2000861201', 'https://openalex.org/W2037377025', 'https://openalex.org/W2038535814', 'https://openalex.org/W2051986755', 'https://openalex.org/W2055951016', 'https://openalex.org/W2059468409', 'https://openalex.org/W2063033401', 'https://openalex.org/W2065419533', 'https://openalex.org/W2080638211', 'https://openalex.org/W2091732273', 'https://openalex.org/W2098767548', 'https://openalex.org/W2103310388', 'https://openalex.org/W2106989209', 'https://openalex.org/W2110177517', 'https://openalex.org/W2113131907', 'https://openalex.org/W2115068422', 'https://openalex.org/W2116843833', 'https://openalex.org/W2118347756', 'https://openalex.org/W2128109269', 'https://openalex.org/W2134714663', 'https://openalex.org/W2146002757', 'https://openalex.org/W2152348310', 'https://openalex.org/W2159106700', 'https://openalex.org/W2314052274', 'https://openalex.org/W2319957449', 'https://openalex.org/W23367129', 'https://openalex.org/W2338984036', 'https://openalex.org/W2340084730', 'https://openalex.org/W2404814415', 'https://openalex.org/W2415772186', 'https://openalex.org/W3146223861', 'https://openalex.org/W4292806894', 'https://openalex.org/W60457073'], 'related_works': ['https://openalex.org/W4283524728', 'https://openalex.org/W3030711132', 'https://openalex.org/W2411121127', 'https://openalex.org/W2396165291', 'https://openalex.org/W2366611537', 'https://openalex.org/W2314544353', 'https://openalex.org/W2227428044', 'https://openalex.org/W2138243862', 'https://openalex.org/W2106806370', 'https://openalex.org/W2020756831'], 'abstract_inverted_index': {'Abstract': [0], 'Objective': [1], 'To': [2], 'compare': [3], 'the': [4, 113, 126, 137, 154, 183, 216, 227], 'benefits': [5, 266], 'of': [6, 23, 33, 116, 119, 182, 239], 'initiating': [7], 'treatment': [8, 25, 50, 70, 268], 'with': [9, 21, 29, 51, 234, 247, 256, 269], 'methotrexate': [10], '(MTX)': [11], 'and': [12, 47, 76, 88, 99, 101, 130, 141, 158, 193, 220, 258, 264], 'infliximab': [13, 89, 129, 133, 157, 161, 219, 223, 259], '(anti–tumor': [14], 'necrosis': [15], 'factor': [16], 'α': [17], '[anti‐TNFα]': [18], 'monoclonal': [19], 'antibody)': [20], 'those': [22, 169], 'MTX': [24, 52, 80, 171, 257, 270], 'alone': [26, 172], 'in': [27, 64, 153, 177, 215, 226, 250], 'patients': [28, 39, 60, 246], 'rheumatoid': [30], 'arthritis': [31], '(RA)': [32], '≤3': [34], "years'": [35], 'duration.': [36], 'Methods': [37], 'RA': [38, 249], 'were': [40, 61, 82, 93], 'eligible': [41], 'if': [42], 'they': [43], 'had': [44], 'active': [45, 248], 'disease': [46], 'no': [48], 'prior': [49], 'or': [53, 90], 'a': [54, 65, 235], 'TNFα': [55], 'inhibitor.': [56], 'One': [57], 'thousand': [58], 'forty‐nine': [59], 'randomly': [62], 'assigned': [63], '4:5:5': [66], 'ratio': [67], 'to': [68, 85], '3': [69], 'groups:': [71], 'MTX–placebo,': [72], 'MTX–3': [73, 127, 155, 217], 'mg/kg': [74, 78, 128, 132, 156, 160, 218, 222], 'infliximab,': [75], 'MTX–6': [77, 131, 159, 221], 'infliximab.': [79], 'dosages': [81], 'rapidly': [83], 'escalated': [84], '20': [86], 'mg/week,': [87], 'placebo': [91], 'infusions': [92], 'given': [94], 'at': [95, 187], 'weeks': [96, 104], '0,': [97], '2,': [98], '6,': [100], 'every': [102], '8': [103], 'thereafter': [105], 'through': [106], 'week': [107, 111, 188], '46.': [108], 'Results': [109], 'At': [110], '54,': [112], 'median': [114], 'percentage': [115], 'American': [117], 'College': [118], 'Rheumatology': [120], 'improvement': [121], '(ACR‐N)': [122], 'was': [123, 232], 'higher': [124, 237], 'for': [125, 136, 149, 205], 'groups': [134, 162, 224], 'than': [135, 168, 225, 267], 'MTX–placebo': [138, 228], 'group': [139], '(38.9%': [140], '46.7%': [142], 'versus': [143, 197], '26.4%,': [144], 'respectively;': [145, 201], 'P': [146, 202], '<': [147, 203], '0.001': [148, 204], 'both': [150], 'comparisons).': [151], 'Patients': [152], 'also': [163], 'showed': [164], 'less': [165], 'radiographic': [166], 'progression': [167], 'receiving': [170], '(mean': [173], '±': [174, 191, 195, 199], 'SD': [175], 'changes': [176], 'van': [178], 'der': [179], 'Heijde': [180], 'modification': [181], 'total': [184], 'Sharp': [185], 'score': [186], '54:': [189], '0.4': [190], '5.8': [192], '0.5': [194], '5.6': [196], '3.7': [198], '9.6,': [200], 'each': [206], 'comparison).': [207], 'In': [208], 'addition,': [209], 'physical': [210], 'function': [211], 'improved': [212], 'significantly': [213, 236], 'more': [214], 'group.': [229], 'Infliximab': [230], 'therapy': [231, 255], 'associated': [233], 'incidence': [238], 'serious': [240], 'infections,': [241], 'especially': [242], 'pneumonia.': [243], 'Conclusion': [244], 'For': [245], 'its': [251], 'early': [252], 'stages,': [253], 'combination': [254], 'provides': [260], 'greater': [261], 'clinical,': [262], 'radiographic,': [263], 'functional': [265], 'alone.': [271]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1999777294', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 19}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 27}, {'year': 2018, 'cited_by_count': 32}, {'year': 2017, 'cited_by_count': 33}, {'year': 2016, 'cited_by_count': 59}, {'year': 2015, 'cited_by_count': 58}, {'year': 2014, 'cited_by_count': 50}, {'year': 2013, 'cited_by_count': 74}, {'year': 2012, 'cited_by_count': 72}], 'updated_date': '2024-12-19T05:58:49.062223', 'created_date': '2016-06-24'}