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[76, 179], 'multiple': [77], 'adaptive': [78], 'mutations': [79, 171, 180, 195, 248], 'various': [82], 'genes.': [84], 'To': [85], 'better': [86], 'understand': [87, 133], 'species': [92], 'real': [94], 'time,': [95], 'we': [96], 'passaged': [97], 'mouse-adapted': [98], 'A/PR8/34': [99], '(PR8)': [100], 'guinea': [102, 139, 142], 'pigs.': [103, 140], 'Guinea': [104], 'pigs,': [105], 'unlike': [106], 'mice,': [107], 'support': [108], 'spontaneous': [109], 'robust': [111], 'transmission.': [113], 'For': [114], 'some': [115], 'strains,': [117], 'including': [118], 'PR8,': [119], 'is': [121], 'required': [122], 'for': [123], 'attain': [127], 'transmissibility,': [128], 'providing': [129], 'an': [130], 'opportunity': [131], 'evolution': [135], 'transmissibility': [137], 'Multiple': [141], 'pig-adapted': [143], 'PR8': [144, 223], 'mutants': [145], 'generated': [146], 'by': [147, 161], 'serial': [148], 'nasal': [149], 'wash': [150], 'passaging': [151], 'independent': [153], 'lines': [154], 'replicated': [155], 'more': [156], 'efficiently': [157], 'were': [159], 'cocaging.': [162], 'All': [163], 'transmissible': [164], 'variants': [165, 192], 'possessed': [166], 'one': [167], 'two': [169], 'nonsynonymous': [170], 'M1,': [173], 'either': [174], 'alone': [175], 'or': [176, 185], 'combination': [178], 'PB2,': [182], 'HA,': [183], 'NP,': [184], 'NA.': [186], 'Rapid': [187], 'independently': [190], 'selected': [191], 'combined': [193], 'beneficial': [194], 'NP': [197, 218], 'M1': [199, 220], 'form': [201], 'fittest': [203], 'capable': [205], 'being': [207], 'transmitted.': [208], 'These': [209], 'findings': [210], 'provide': [211], 'further': [212], 'insight': [213], 'genetic': [215], 'determinants': [216], 'involved': [221], 'clearly': [234], 'show': [235], 'benefit': [237], 'segmented': [240], 'genome': [241], 'rapidly': [243], 'generating': [244], 'optimal': [245], 'combinations': [246], 'evolution.': [251]}, 'cited_by_api_url': 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