Title: Synthesis and conversion study of a radiolabeled putative ecdysone precursor, 5β-cholest-7-ene-3β,6α,14α-triol in Locusta migratoria prothoracic glands
Abstract: In previous studies, we have characterized the last three steps of the biosynthetic pathway of the insect molting hormone, ecdysone. They consist of a series of hydroxylations at the C-25, C-22, and C-2 positions. To explore an early step, we synthesized 5β-cholest-7-ene-3β,6α,14α-triol in tritiated form. Incubation of this triol with insect prothoracic glands, a well-known site of ecdysone biosynthesis, showed that this molecule can be hydroxylated at the C-25, C-22, and C-2 positions, but neither the triol nor the resulting compounds could be oxidized at the C-6 position to give ecdysone. (Steroids 56: 316–319, 1991)
Publication Year: 1991
Publication Date: 1991-06-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 9
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