Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1999238614', 'doi': 'https://doi.org/10.1016/j.biopsych.2003.09.003', 'title': 'Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression', 'display_name': 'Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression', 'publication_year': 2003, 'publication_date': '2003-11-01', 'ids': {'openalex': 'https://openalex.org/W1999238614', 'doi': 'https://doi.org/10.1016/j.biopsych.2003.09.003', 'mag': '1999238614', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14625137'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biopsych.2003.09.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205482884', 'display_name': 'Biological Psychiatry', 'issn_l': '0006-3223', 'issn': ['0006-3223', '1873-2402'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029891285', 'display_name': 'Andrew Holmes', 'orcid': 'https://orcid.org/0000-0001-7308-1129'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew Holmes', 'raw_affiliation_strings': ['Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892-1375, USA.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Behavioral Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892-1375, USA.', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063256213', 'display_name': 'Dennis L. Murphy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210158500', 'display_name': 'National Institute of Mental Health', 'ror': 'https://ror.org/04xeg9z08', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210158500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Dennis L Murphy', 'raw_affiliation_strings': ['Laboratory of Clinical Science (DLM), National Institute of Mental Health, Bethesda, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Clinical Science (DLM), National Institute of Mental Health, Bethesda, Maryland, USA', 'institution_ids': ['https://openalex.org/I4210158500']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5063501456', 'display_name': 'Jacqueline N. Crawley', 'orcid': 'https://orcid.org/0000-0002-1224-995X'}, 'institutions': [{'id': 'https://openalex.org/I4210158500', 'display_name': 'National Institute of Mental Health', 'ror': 'https://ror.org/04xeg9z08', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210158500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jacqueline N Crawley', 'raw_affiliation_strings': ['Laboratory of Behavioral Neuroscience (AH, JNC), National Institute of Mental Health, Bethesda, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Behavioral Neuroscience (AH, JNC), National Institute of Mental Health, Bethesda, Maryland, USA', 'institution_ids': ['https://openalex.org/I4210158500']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4990, 'currency': 'USD', 'value_usd': 4990, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.913, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 326, 'citation_normalized_percentile': {'value': 0.999839, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '54', 'issue': '10', 'first_page': '953', 'last_page': '959'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10056', 'display_name': 'Neurobiological Mechanisms of Drug Addiction and Depression', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10056', 'display_name': 'Neurobiological Mechanisms of Drug Addiction and Depression', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11178', 'display_name': 'Structure and Function of G Protein-Coupled Receptors', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11541', 'display_name': 'Oxytocin and Social Behavior Regulation', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/3207', 'display_name': 'Social Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/serotonin', 'display_name': 'Serotonin', 'score': 0.482354}, {'id': 'https://openalex.org/keywords/knockout-mouse', 'display_name': 'Knockout mouse', 'score': 0.45744535}], 'concepts': [{'id': 'https://openalex.org/C2778897192', 'wikidata': 'https://www.wikidata.org/wiki/Q410142', 'display_name': 'Serotonin transporter', 'level': 4, 'score': 0.9437461}, {'id': 'https://openalex.org/C2908747647', 'wikidata': 'https://www.wikidata.org/wiki/Q238516', 'display_name': 'Serotonin Plasma Membrane Transport Proteins', 'level': 5, 'score': 0.78017986}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.7524797}, {'id': 'https://openalex.org/C558461103', 'wikidata': 'https://www.wikidata.org/wiki/Q154430', 'display_name': 'Anxiety', 'level': 2, 'score': 0.5047599}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.48639038}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.47637293}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.47015998}, {'id': 'https://openalex.org/C182704531', 'wikidata': 'https://www.wikidata.org/wiki/Q1364740', 'display_name': 'Knockout mouse', 'level': 3, 'score': 0.45744535}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.44811964}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.43953356}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39623997}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3537678}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2675304}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.2471452}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.20551988}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.193335}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16536143}], 'mesh': [{'descriptor_ui': 'D001007', 'descriptor_name': 'Anxiety', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003863', 'descriptor_name': 'Depression', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D026901', 'descriptor_name': 'Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009419', 'descriptor_name': 'Nerve Tissue Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001007', 'descriptor_name': 'Anxiety', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001007', 'descriptor_name': 'Anxiety', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D001522', 'descriptor_name': 'Behavior, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002352', 'descriptor_name': 'Carrier Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003863', 'descriptor_name': 'Depression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003863', 'descriptor_name': 'Depression', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050486', 'descriptor_name': 'Serotonin Plasma Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biopsych.2003.09.003', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205482884', 'display_name': 'Biological Psychiatry', 'issn_l': '0006-3223', 'issn': ['0006-3223', '1873-2402'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14625137', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.44, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1556074533', 'https://openalex.org/W1597146577', 'https://openalex.org/W1629984745', 'https://openalex.org/W1713895945', 'https://openalex.org/W1776942521', 'https://openalex.org/W1856909901', 'https://openalex.org/W1886309510', 'https://openalex.org/W1965018692', 'https://openalex.org/W1966271875', 'https://openalex.org/W1972088939', 'https://openalex.org/W1979073775', 'https://openalex.org/W1985212461', 'https://openalex.org/W1991155688', 'https://openalex.org/W1992991045', 'https://openalex.org/W1996340413', 'https://openalex.org/W1997688244', 'https://openalex.org/W1999981396', 'https://openalex.org/W2004213733', 'https://openalex.org/W2008119750', 'https://openalex.org/W2008403930', 'https://openalex.org/W2016166396', 'https://openalex.org/W2020291589', 'https://openalex.org/W2021793145', 'https://openalex.org/W2028838843', 'https://openalex.org/W2037103035', 'https://openalex.org/W2037646583', 'https://openalex.org/W2044092930', 'https://openalex.org/W2045174454', 'https://openalex.org/W2051918534', 'https://openalex.org/W2062418646', 'https://openalex.org/W2074245141', 'https://openalex.org/W2077409789', 'https://openalex.org/W2087064986', 'https://openalex.org/W2088160189', 'https://openalex.org/W2088842558', 'https://openalex.org/W2097785193', 'https://openalex.org/W2102457259', 'https://openalex.org/W2106095564', 'https://openalex.org/W2110067113', 'https://openalex.org/W2114462724', 'https://openalex.org/W2117155939', 'https://openalex.org/W2117660213', 'https://openalex.org/W2120182666', 'https://openalex.org/W2121477167', 'https://openalex.org/W2131167630', 'https://openalex.org/W2132167094', 'https://openalex.org/W2133746049', 'https://openalex.org/W2137416893', 'https://openalex.org/W2145728616', 'https://openalex.org/W2147351252', 'https://openalex.org/W2149946283', 'https://openalex.org/W2151055409', 'https://openalex.org/W2153655311', 'https://openalex.org/W2162196924', 'https://openalex.org/W2164967571', 'https://openalex.org/W2172156978', 'https://openalex.org/W2186560115', 'https://openalex.org/W2266226083', 'https://openalex.org/W2479821678'], 'related_works': ['https://openalex.org/W4327766724', 'https://openalex.org/W2168400980', 'https://openalex.org/W2095451289', 'https://openalex.org/W2015140659', 'https://openalex.org/W2009722609', 'https://openalex.org/W1971774752', 'https://openalex.org/W1965033433', 'https://openalex.org/W1962934739', 'https://openalex.org/W1862987663', 'https://openalex.org/W1826125636'], 'abstract_inverted_index': {'Evidence': [0], 'of': [1, 7, 18, 24, 33], 'a': [2, 90], 'link': [3], 'between': [4], 'genetic': [5, 52, 96], 'variation': [6, 97], 'the': [8, 16, 77], 'serotonin': [9, 19, 25, 35, 40, 99], 'transporter': [10, 20, 85, 100], 'and': [11, 13, 36, 43, 61, 72], 'depression': [12], 'anxiety': [14], 'prompted': [15], 'generation': [17], 'knockout': [21], 'mice.': [22], 'Loss': [23], 'reuptake': [26], 'function': [27, 48, 101], 'in': [28, 39, 49, 98], 'knock-outs': [29, 50], 'causes': [30], 'reduced': [31, 59], 'clearance': [32], 'extracellular': [34], 'associated': [37], 'alterations': [38], 'neuronal': [41], 'firing': [42], 'receptor': [44], 'function.': [45], 'Behavioral': [46], 'phenotyping': [47], 'revealed': [51], 'background-related': [53], 'abnormalities,': [54], 'including': [55], 'increased': [56], 'anxiety-like': [57], 'behaviors,': [58], 'aggression,': [60], 'exaggerated': [62], 'stress': [63], 'responses.': [64], 'Ongoing': [65], 'studies': [66], 'focus': [67], 'on': [68], 'identifying': [69], 'environmental,': [70], 'genetic,': [71], 'developmental': [73], 'factors': [74], 'interacting': [75], 'with': [76], 'htt': [78], 'mutation': [79], 'to': [80, 93], 'produce': [81], 'these': [82], 'abnormalities.': [83], 'Serotonin': [84], 'null': [86], 'mutant': [87], 'mice': [88], 'provide': [89], 'model': [91], 'system': [92], 'study': [94], 'how': [95], 'affects': [102], 'risk': [103], 'for': [104], 'neuropsychiatric': [105], 'disease.': [106]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1999238614', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 12}, {'year': 2012, 'cited_by_count': 24}], 'updated_date': '2024-09-12T22:12:51.881907', 'created_date': '2016-06-24'}