Regulation of Integrin αvβ3-mediated Endothelial Cell Migration and Angiogenesis by Integrin α5β1 and Protein Kinase A

Name: Work Video:
Duration: 3 min 30 s
Semi Kim; M. Harris; Judith A. Varner
{'id': 'https://openalex.org/W1998709931', 'doi': 'https://doi.org/10.1074/jbc.m003668200', 'title': 'Regulation of Integrin αvβ3-mediated Endothelial Cell Migration and Angiogenesis by Integrin α5β1 and Protein Kinase A', 'display_name': 'Regulation of Integrin αvβ3-mediated Endothelial Cell Migration and Angiogenesis by Integrin α5β1 and Protein Kinase A', 'publication_year': 2000, 'publication_date': '2000-10-01', 'ids': {'openalex': 'https://openalex.org/W1998709931', 'doi': 'https://doi.org/10.1074/jbc.m003668200', 'mag': '1998709931', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10944524'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m003668200', 'pdf_url': 'http://www.jbc.org/article/S0021925820890942/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820890942/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5020320673', 'display_name': 'Semi Kim', 'orcid': 'https://orcid.org/0000-0001-8043-1465'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Semi Kim', 'raw_affiliation_strings': ['Cancer Center, University of California, San Diego, La Jolla, California 92093-0912, USA.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Center, University of California, San Diego, La Jolla, California 92093-0912, USA.', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5032945163', 'display_name': 'M. Harris', 'orcid': 'https://orcid.org/0000-0002-9084-1633'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Marina Harris', 'raw_affiliation_strings': ['From the Cancer Center, University of California, San Diego, La Jolla, California 92093-0912'], 'affiliations': [{'raw_affiliation_string': 'From the Cancer Center, University of California, San Diego, La Jolla, California 92093-0912', 'institution_ids': ['https://openalex.org/I36258959']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5007491235', 'display_name': 'Judith A. Varner', 'orcid': 'https://orcid.org/0000-0002-9251-0600'}, 'institutions': [{'id': 'https://openalex.org/I36258959', 'display_name': 'University of California, San Diego', 'ror': 'https://ror.org/0168r3w48', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I36258959']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Judith A. Varner', 'raw_affiliation_strings': ['From the Cancer Center, University of California, San Diego, La Jolla, California 92093-0912'], 'affiliations': [{'raw_affiliation_string': 'From the Cancer Center, University of California, San Diego, La Jolla, California 92093-0912', 'institution_ids': ['https://openalex.org/I36258959']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 5.494, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 214, 'citation_normalized_percentile': {'value': 0.945832, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '275', 'issue': '43', 'first_page': '33920', 'last_page': '33928'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/integrin-linked-kinase', 'display_name': 'Integrin-linked kinase', 'score': 0.7117908}], 'concepts': [{'id': 'https://openalex.org/C195687474', 'wikidata': 'https://www.wikidata.org/wiki/Q409715', 'display_name': 'Integrin', 'level': 3, 'score': 0.7551392}, {'id': 'https://openalex.org/C66417403', 'wikidata': 'https://www.wikidata.org/wiki/Q20970072', 'display_name': 'Integrin-linked kinase', 'level': 5, 'score': 0.7117908}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.69613886}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.60595936}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4789339}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.43352097}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.4259102}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.33634531}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.31745273}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.27998248}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23505661}, {'id': 'https://openalex.org/C82495950', 'wikidata': 'https://www.wikidata.org/wiki/Q14911732', 'display_name': 'Cyclin-dependent kinase 2', 'level': 4, 'score': 0.22338286}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20831072}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m003668200', 'pdf_url': 'http://www.jbc.org/article/S0021925820890942/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m003668200', 'pdf_url': 'http://www.jbc.org/article/S0021925820890942/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1514474730', 'https://openalex.org/W1515040694', 'https://openalex.org/W1533675232', 'https://openalex.org/W1577857859', 'https://openalex.org/W1679229092', 'https://openalex.org/W1905978178', 'https://openalex.org/W1919621005', 'https://openalex.org/W1967252793', 'https://openalex.org/W1997182423', 'https://openalex.org/W1999759354', 'https://openalex.org/W2000000541', 'https://openalex.org/W2001753204', 'https://openalex.org/W2009507555', 'https://openalex.org/W2016312253', 'https://openalex.org/W2017092245', 'https://openalex.org/W2029773366', 'https://openalex.org/W2034839112', 'https://openalex.org/W2039317622', 'https://openalex.org/W2041069947', 'https://openalex.org/W2044725419', 'https://openalex.org/W2047196924', 'https://openalex.org/W2049865066', 'https://openalex.org/W2052952011', 'https://openalex.org/W2053144857', 'https://openalex.org/W2065051915', 'https://openalex.org/W2077090481', 'https://openalex.org/W2077246501', 'https://openalex.org/W2094844458', 'https://openalex.org/W2113267611', 'https://openalex.org/W2113324173', 'https://openalex.org/W2125621362', 'https://openalex.org/W2130172628', 'https://openalex.org/W2138264536', 'https://openalex.org/W2141524439', 'https://openalex.org/W2142929443', 'https://openalex.org/W2165525793', 'https://openalex.org/W2165899646', 'https://openalex.org/W2188422153', 'https://openalex.org/W2283015743', 'https://openalex.org/W2287029392', 'https://openalex.org/W2470199831', 'https://openalex.org/W264187420', 'https://openalex.org/W445077005'], 'related_works': ['https://openalex.org/W2955323236', 'https://openalex.org/W2938705993', 'https://openalex.org/W2774612544', 'https://openalex.org/W2075734225', 'https://openalex.org/W2047386879', 'https://openalex.org/W2042474810', 'https://openalex.org/W2024389899', 'https://openalex.org/W2014142027', 'https://openalex.org/W1980789737', 'https://openalex.org/W1973974098'], 'abstract_inverted_index': {'Recent': [0, 145, 3158, 3845], 'studies': [1, 146, 442, 1028, 1179, 3159, 3846], 'indicate': [2, 147, 3641], 'that': [3, 19, 84, 148, 164, 229, 333, 690, 950, 1020, 1031, 1182, 1486, 2383, 2426, 3064, 3161, 3310, 3535, 3642, 3654, 3848, 3900, 3976, 3989, 4201, 4278], 'angiogenesis': [4, 105, 129, 149, 250, 274, 752, 786, 934, 957, 3174, 3298, 3675, 3858], 'depends,': [5, 150], 'in': [6, 34, 102, 106, 151, 179, 247, 251, 435, 458, 574, 637, 684, 702, 1495, 1498, 1551, 1819, 1825, 1862, 1891, 1896, 1927, 1933, 1946, 1951, 1968, 1973, 2047, 2056, 2089, 2149, 2242, 2258, 2300, 2332, 2343, 2437, 2454, 2522, 2534, 2551, 2612, 2626, 2641, 2680, 2731, 2759, 2772, 2788, 2820, 2924, 2933, 2943, 2955, 2985, 3012, 3044, 3048, 3105, 3122, 3146, 3175, 3179, 3386, 3400, 3518, 3522, 3659, 4053, 4057, 4100, 4107, 4138, 4155, 4179, 4355], 'part,': [7, 152], 'on': [8, 28, 56, 100, 138, 153, 173, 201, 245, 283, 335, 1378, 1454, 1522, 1856, 2450, 2598, 2814, 3060, 3420, 3439, 3460, 3466, 3556, 3567, 3582, 3663, 3890, 3908, 3913, 3953, 3960, 4026, 4078, 4090, 4116, 4126, 4147, 4211, 4230, 4264, 4287], 'ligation': [9, 48, 140, 154, 193, 285, 1329, 3977, 3997], 'of': [10, 25, 40, 49, 76, 111, 142, 155, 170, 185, 194, 221, 256, 287, 309, 319, 446, 579, 612, 742, 779, 927, 929, 956, 1005, 1015, 1034, 1044, 1330, 1381, 1449, 1492, 1501, 1517, 1525, 1536, 1583, 1865, 1917, 2015, 2162, 2175, 2212, 2256, 2303, 2306, 2335, 2390, 2424, 2432, 2466, 2472, 2509, 2530, 2557, 2602, 2609, 2618, 2635, 2674, 2682, 2685, 2696, 2825, 2880, 2888, 2936, 2958, 2968, 3001, 3053, 3098, 3163, 3293, 3370, 3396, 3418, 3501, 3525, 3530, 3539, 3561, 3576, 3666, 3855, 3886, 3926, 3937, 3978, 3990, 3998, 4035, 4042, 4049, 4075, 4113, 4167, 4189, 4228, 4237, 4245, 4261, 4283, 4331, 4345], 'integrin': [11, 20, 26, 50, 143, 156, 165, 171, 195, 288, 682, 691, 743, 1036, 1331, 1344, 1446, 1487, 1493, 1502, 3164, 3410, 3425, 3467, 3562, 3577, 3643, 4006, 4216, 4275, 4311, 4346], 'α5β1': [12, 21, 94, 121, 157, 166, 239, 266, 744, 1345, 1488, 1720, 3165, 3371, 3411, 3548, 3578, 3622, 3629, 3637, 3893, 3979, 3999, 4246, 4262], 'by': [13, 42, 120, 133, 158, 187, 265, 278, 441, 705, 936, 944, 1037, 1343, 1534, 1594, 1631, 1638, 1667, 1816, 2165, 2373, 2604, 2929, 2951, 2991, 3039, 3138, 3300, 3304, 3315, 3627, 3633, 3892, 3918, 3930, 3980, 4000, 4039, 4083, 4098, 4173, 4204, 4281], 'fibronectin.': [14, 159, 3568, 3972], 'Evidence': [15, 160], 'is': [16, 161, 328, 1018, 1452, 1520, 3392, 3550, 3915, 4037, 4080, 4092, 4118, 4128, 4149], 'now': [17, 162], 'provided': [18, 163, 1630, 1637, 1666], 'regulates': [22, 167, 1186, 1489, 3985], 'the': [23, 47, 114, 139, 168, 192, 259, 284, 316, 339, 430, 444, 607, 1012, 1032, 1042, 1379, 1490, 1523, 1727, 1740, 1863, 2013, 2166, 2176, 2253, 2301, 2333, 2353, 2356, 2370, 2375, 2387, 2391, 2422, 2430, 2433, 2451, 2456, 2473, 2562, 2599, 2619, 2627, 2697, 2823, 2931, 2934, 2953, 2956, 2999, 3049, 3317, 3368, 3414, 3515, 3519, 3523, 3537, 3664, 3852, 3898, 3923, 3934, 4073, 4095, 4224, 4231, 4259, 4273, 4328, 4343], 'function': [24, 169, 1519, 1658, 2060, 2073, 2079, 2531, 3405, 3549, 3658], 'αvβ3': [27, 172, 1332, 1447, 1494, 1518, 3426, 3540], 'endothelial': [29, 43, 97, 125, 174, 188, 242, 270, 303, 946, 1559, 3306, 3383, 3389, 3436, 3480, 3553, 3667, 3728, 3887, 3901, 3957, 3981, 4001, 4008, 4043, 4296, 4348], 'cells': [30, 44, 175, 189, 2055, 2296, 2366, 2425, 2447, 2467, 3481, 3670, 3958, 4009, 4044, 4064, 4077, 4115, 4142, 4159, 4183, 4229, 4297, 4349, 4357, 4363], 'during': [31, 176, 452, 1025, 3674, 4323], 'their': [32, 177, 3380, 4022], 'migration': [33, 55, 99, 127, 178, 200, 244, 272, 1192, 1339, 1451, 1510, 2259, 3385, 3391, 3417, 3438, 3489, 3510, 3555, 3581, 3626, 3648, 3889, 3907, 3912, 3952, 4059, 4074, 4089, 4112, 4209, 4222], 'vitro': [35, 103, 180, 248, 1496], 'or': [36, 93, 104, 116, 181, 238, 249, 261, 708, 1789, 1873, 1922, 2031, 2083, 2112, 2228, 2276, 2287, 2291, 2317, 2324, 2526, 2535, 2546, 2554, 2586, 2722, 2776, 2817, 2822, 2829, 3051, 3071, 3107, 3126, 3130, 3166, 3498, 3521, 3966, 4029], 'angiogenesisin': [37, 182], 'vivo.': [38, 107, 183, 252, 1499], 'Secretion': [39, 184], 'fibronectin': [41, 186, 434, 448, 571, 608, 614, 678, 695, 746, 1584, 3072, 3673, 3731, 3856, 3903, 3938, 3983, 4004, 4036, 4148, 4202], 'leads': [45, 190, 4326], 'to': [46, 66, 191, 211, 315, 1336, 1376, 1883, 1976, 2118, 2120, 2252, 2350, 2355, 2386, 2417, 2561, 2593, 2616, 3006, 3089, 3117, 3156, 3378, 3382, 3449, 3490, 3514, 3851, 4014, 4024, 4070, 4094, 4109, 4120, 4131, 4135, 4152, 4207, 4214, 4220, 4271, 4327], 'α5β1,': [51, 196, 610, 683], 'which': [52, 136, 197, 281, 581, 2455, 3464], 'potentiates': [53, 198, 4005], 'αvβ3-mediated': [54, 60, 124, 199, 205, 269, 1504, 3509, 3624, 3646, 4250, 4276], 'vitronectin': [57, 67, 101, 202, 212, 246, 3440, 3450, 3557, 3583, 3891, 3914, 3962, 4079, 4091, 4117, 4208, 4288], 'without': [58, 203, 1511, 3587, 3649], 'influencing': [59, 204, 3650], 'cell': [61, 64, 98, 126, 206, 209, 243, 271, 304, 1191, 1338, 1509, 1560, 3061, 3384, 3390, 3437, 3462, 3488, 3554, 3580, 3589, 3625, 3635, 3888, 3906, 3911, 4002, 4033, 4251, 4265, 4294], 'adhesion.': [62, 207], 'Endothelial': [63, 208, 3669, 4032], 'attachment': [65, 210, 3590, 4225, 4252], 'suppresses': [68, 213], 'protein': [69, 214, 294, 433, 1456, 1526, 2230, 2816, 3099, 4016, 4050, 4190], 'kinase': [70, 215, 295, 1457, 1527, 2865, 2904, 3132, 4191], 'A': [71, 216, 296, 426, 1528, 2866, 3133, 4192], '(PKA)': [72, 217, 1529], 'activity,': [73, 135, 218, 280], 'while': [74, 219, 3422], 'addition': [75, 220], 'soluble': [77, 222], 'anti-α5β1': [78, 223, 2059, 2533, 2775, 2828, 3432, 3456, 4136, 4153], 'restores': [79, 224], 'this': [80, 225, 1481, 4324], 'activity.': [81, 226], 'Moreover,': [82, 227], 'agents': [83, 228], 'activate': [85, 230], 'intracellular': [86, 231], 'PKA,': [87, 232], 'such': [88, 233, 1187, 4335], 'as': [89, 234, 1189, 1371, 1985, 2160, 2183, 2280, 2282, 2464, 2479, 3388, 3564, 3566, 4186, 4303, 4305, 4336], 'forskolin,': [90, 235, 2585], 'dibutyryl': [91, 236, 2131, 2322, 2589], 'cAMP': [92, 237, 2132, 2590], 'antagonists,': [95, 240], 'suppress': [96, 241], 'In': [108, 253, 1480, 2011, 2128, 2293, 2570, 3454, 3726, 3941, 4068, 4105, 4163, 4342], 'contrast,': [109, 254, 3455, 3942], 'inhibitors': [110, 255, 1535], 'PKA': [112, 134, 257, 279, 1768, 2923, 2941, 2947, 2960, 2995, 3005, 3010], 'reverse': [113, 258], 'anti-migratory': [115, 260], 'anti-angiogenic': [117, 262], 'effects': [118, 263, 318], 'mediated': [119, 264, 1342], 'antagonists.': [122, 267], 'Therefore,': [123, 268, 3547], 'and': [128, 273, 325, 338, 454, 457, 639, 643, 679, 738, 745, 750, 1009, 1305, 1340, 1497, 1508, 1530, 1540, 1567, 1570, 1617, 1662, 1691, 1823, 1894, 1949, 1971, 2039, 2108, 2138, 2234, 2273, 2406, 2729, 2770, 2786, 2843, 2860, 2882, 2910, 2945, 2977, 3017, 3042, 3073, 3119, 3153, 3172, 3178, 3372, 3416, 3433, 3558, 3572, 4018, 4102, 4133, 4140, 4157, 4169, 4181, 4226, 4240, 4267, 4315, 4338], 'can': [130, 275, 1040, 1531], 'be': [131, 276, 1532], 'regulated': [132, 277], 'depends': [137, 282, 334, 3465], 'state': [141, 286], 'α5β1.': [144, 289, 4217, 4284], 'basic': [290, 937], 'fibroblast': [291, 938, 1758], 'growth': [292, 308, 336, 706, 748, 939, 947, 1561, 1759, 2563, 3170, 3307], 'factor': [293, 940, 1760, 3171], 'bovine': [297, 1565, 1801, 1930, 2044, 2099, 2239, 2733, 2761, 3076], 'serum': [298, 1802, 1931, 2045, 2100, 2240, 2734, 2762, 3077], 'albumin': [299, 1803, 1932, 2046, 2241, 2735, 2763], 'human': [300, 3180], 'umbilical': [301], 'vein': [302], 'chorioallantoic': [305, 2506], 'membrane': [306], 'The': [307, 2156, 2209, 2460, 3111, 3883], 'new': [310], 'blood': [311, 450, 2686, 3736], 'vessels,': [312], 'angiogenesis,': [313, 1016, 3374], 'contributes': [314, 4206], 'adverse': [317], 'solid': [320, 709], 'tumor': [321, 459], 'cancer,': [322], 'arthritis,': [323], 'psoriasis,': [324], 'blindness.': [326], 'Angiogenesis': [327, 2475], 'a': [329, 577, 2340, 2408, 2536, 2607, 2633, 2642, 2672, 2871, 2959, 3147, 3532, 3660, 4365], 'complex': [330], 'biological': [331], 'process': [332], 'factors': [337, 707], 'extracellular': [340, 431, 4232], 'matrix': [341, 432, 2815], '(1Breier': [342], 'G.': [343, 361, 464, 468, 472, 517, 521, 545, 557, 813, 3236, 3278, 3741, 3745, 3749, 3794, 3798, 3822, 3834], 'Risau': [344, 366], 'W.': [345, 367, 408], 'Trends': [346], 'Cell': [347, 897, 1056, 1168, 1202, 1295, 1355, 1394, 1434, 1470, 1980], 'Biol.': [348, 395, 859, 1057, 1094, 1142, 1169, 1203, 1269, 1296, 1317, 1356, 1395, 1435, 1471, 1606, 2653], '1996;': [349, 396, 1096, 1319], '6:': [350], '454-456Abstract': [351], 'Full': [352, 399, 504, 626, 725, 727, 767, 769, 820, 972, 974, 1147, 1149, 1274, 1276, 1611, 2001, 2003, 2199, 2201, 2495, 2497, 3200, 3202, 3243, 3335, 3337, 3608, 3610, 3694, 3716, 3718, 3781, 3873, 3875], 'Text': [353, 400, 505, 627, 726, 728, 768, 770, 821, 973, 975, 1148, 1150, 1275, 1277, 1612, 2002, 2004, 2200, 2202, 2496, 2498, 3201, 3203, 3244, 3336, 3338, 3609, 3611, 3695, 3717, 3719, 3782, 3874, 3876], 'PDF': [354, 401, 506, 628, 729, 771, 822, 976, 1151, 1278, 1613, 2005, 2203, 2499, 3204, 3245, 3339, 3612, 3696, 3720, 3783, 3877], 'PubMed': [355, 373, 385, 402, 413, 481, 507, 563, 601, 629, 656, 730, 772, 797, 823, 846, 902, 921, 977, 998, 1061, 1099, 1126, 1152, 1173, 1207, 1253, 1279, 1300, 1322, 1360, 1399, 1439, 1475, 1614, 1654, 2006, 2204, 2500, 3205, 3220, 3246, 3269, 3340, 3361, 3613, 3697, 3721, 3758, 3784, 3840, 3878], 'Scopus': [356, 374, 386, 403, 414, 482, 508, 530, 564, 630, 731, 773, 798, 824, 847, 922, 978, 999, 1062, 1100, 1127, 1153, 1174, 1208, 1254, 1280, 1301, 1323, 1361, 1400, 1440, 1476, 2007, 2205, 2501, 3206, 3221, 3247, 3270, 3341, 3362, 3614, 3698, 3722, 3759, 3785, 3807, 3841, 3879], '(147)': [357], 'Google': [358, 376, 388, 405, 416, 424, 484, 510, 532, 566, 602, 632, 657, 669, 733, 775, 800, 826, 849, 863, 888, 903, 924, 980, 1001, 1064, 1083, 1102, 1129, 1155, 1176, 1210, 1229, 1256, 1282, 1303, 1325, 1363, 1402, 1421, 1442, 1478, 1615, 1655, 2009, 2207, 2503, 2657, 3208, 3223, 3249, 3272, 3289, 3343, 3364, 3616, 3700, 3724, 3761, 3787, 3809, 3843, 3881], 'Scholar,': [359, 377, 389, 406, 417, 485, 511, 533, 658, 801, 827, 850, 864, 889, 904, 981, 1065, 1084, 1103, 1130, 1156, 1211, 1230, 1257, 1283, 1403, 1422, 3209, 3224, 3250, 3344, 3701, 3762, 3788, 3810], '2Breier': [360], 'Damert': [362], 'A.': [363, 466, 539, 543, 547, 3743, 3816, 3820, 3824], 'Plate': [364], 'K.H.': [365], 'Thromb.': [368], 'Haemost.': [369], '1997;': [370, 410, 421, 560, 666, 1123, 1144, 1250, 1271, 3286, 3837], '78:': [371], '678-683Crossref': [372], '(123)': [375], '3Folkman': [378], 'J.': [379, 470, 476, 498, 513, 525, 720, 762, 840, 896, 967, 1055, 1069, 1078, 1088, 1121, 1141, 1167, 1201, 1215, 1224, 1248, 1268, 1294, 1311, 1354, 1393, 1407, 1416, 1433, 1469, 1605, 1623, 1996, 2194, 2490, 3195, 3263, 3284, 3330, 3603, 3688, 3711, 3747, 3753, 3775, 3790, 3802, 3868], 'Nat.': [380, 558, 3835], 'Med.': [381], '1995;': [382, 843, 899, 918, 995, 3266, 3358], '1:': [383], '27-31Crossref': [384], '(7235)': [387], '4Stromblad': [390], 'S.': [391, 712, 754, 831, 959, 1988, 2186, 2482, 3187, 3254, 3280, 3322, 3595, 3703, 3860], 'Cheresh': [392, 791, 814, 838, 855, 892, 915, 992, 2649, 3214, 3237, 3261, 3355], 'D.A.': [393, 792, 815, 839, 856, 893, 916, 993, 1602, 2650, 3215, 3238, 3262, 3356], 'Chem.': [394, 1143, 1270, 1607], '3:': [397], '881-885Abstract': [398], '(176)': [404], '5Risau': [407], 'Nature.': [409], '386:': [411], '671-674Crossref': [412], '(4866)': [415], '6Varner': [418], 'J.A.': [419, 718, 760, 870, 914, 965, 991, 1994, 2192, 2488, 3193, 3328, 3354, 3601, 3709, 3866], 'Exs.': [420], '79:': [422, 502, 818, 3241, 3692, 3779], '361-390PubMed': [423], 'Scholar).': [425, 567, 603, 670, 734, 776, 925, 1002, 1177, 1326, 1364, 1443, 1479, 1656, 2010, 2208, 2504, 2658, 3290, 3365, 3617, 3725, 3844, 3882], 'potential': [427, 675], 'role': [428], 'for': [429, 677, 1791, 1804, 1850, 1876, 1888, 1900, 1936, 1958, 2033, 2050, 2122, 2231, 2245, 2359, 2397, 2403, 2736, 2752, 2764, 2834, 2916, 3082, 3150, 3409, 3476, 3541, 3552, 4021], 'vascular': [436, 642, 945, 3305], 'development': [437, 453, 575, 638], 'was': [438, 1592, 1636, 1670, 1677, 1712, 1761, 2133, 2140, 2147, 2458, 2670, 2868, 2927, 2989, 2996, 3015, 3103], 'initially': [439], 'suggested': [440], 'demonstrating': [443], 'presence': [445, 1864, 2302, 2334, 2824, 2935, 2957, 3050, 3524, 4344], 'oncofetal': [447, 3730], 'around': [449, 3734], 'vessels': [451, 3737], 'wound': [455], 'healing': [456], 'tissue': [460], '(7Castellani': [461, 3738], 'P.': [462, 489, 515, 553, 1113, 1240, 1622, 3679, 3739, 3766, 3792, 3830], 'Viale': [463, 3740], 'Dorcaratto': [465, 3742], 'Nicolo': [467, 516, 3744, 3793], 'Kaczmarek': [469, 3746], 'Querze': [471, 544, 3748, 3821], 'Zardi': [473, 522, 554, 3750, 3799, 3831], 'L.': [474, 523, 549, 555, 1115, 1140, 1242, 1267, 3751, 3800, 3826, 3832], 'Int.': [475, 524, 3752, 3801], 'Cancer.': [477, 526, 3754, 3803], '1994;': [478, 527, 794, 817, 1058, 1080, 1204, 1226, 1357, 1396, 1418, 3217, 3240, 3755, 3804], '59:': [479, 3756], '612-618Crossref': [480, 3757], '(279)': [483, 3760], '8Clark': [486, 3763], 'R.A.F.': [487, 3677, 3764], 'DellaPelle': [488, 3678, 3765], 'Manseua': [490, 3680, 3767], 'E.': [491, 541, 621, 3681, 3768, 3818], 'Lanigan': [492, 3682, 3769], 'J.M.': [493, 3683, 3770], 'Dvorak': [494, 3684, 3771], 'H.F.': [495, 3685, 3772], 'Colvin': [496, 3686, 3773], 'R.B.': [497, 3687, 3774], 'Invest.': [499, 842, 3265, 3689, 3776], 'Dermatol.': [500, 3690, 3777], '1982;': [501, 3691, 3778], '269-276Abstract': [503, 3693, 3780], '(154)': [509, 3699, 3786], '9Kaczmarek': [512, 3789], 'Castellani': [514, 3791], 'Spina': [518, 3795], 'B.': [519, 537, 1090, 1105, 1232, 1313, 3796, 3814], 'Allemanni': [520, 3797], '58:': [528, 886, 3805], '11-16Crossref': [529, 3806], '(139)': [531, 3808], '10Neri': [534, 3811], 'D.': [535, 835, 1107, 1234, 3258, 3812], 'Carnemolla': [536, 3813], 'Nissim': [538, 3815], 'Blaza': [540, 3817], 'Leprini': [542, 3819], 'Pina': [546, 3823], 'Tarli': [548, 3825], 'Halin': [550, 3827], 'C.': [551, 1077, 1223, 1415, 3828], 'Neri': [552, 3829], 'Winter': [556, 3833], 'Biotech.': [559, 3836], '15:': [561, 3838], '1271-1275Crossref': [562, 3839], '(286)': [565, 3842], 'Interestingly,': [568, 777, 3569], 'mice': [569, 605, 3185], 'lacking': [570, 606], 'die': [572, 635], 'early': [573, 636], 'from': [576, 1543, 1573, 1587, 1672, 1679, 1698, 1714, 1752, 1763, 1773, 1813, 2352, 2369, 2873, 2998, 3036, 3100], 'collection': [578], 'defects,': [580], 'includes': [582], 'an': [583, 2379, 3393, 4054], 'improperly': [584], 'formed': [585], 'vasculature': [586], '(11George': [587], 'E.L.': [588], 'Georges': [589], 'E.N.': [590], 'Patel-King': [591], 'R.S.': [592], 'Rayburn': [593, 648], 'H.': [594, 649], 'Hynes': [595, 650, 663], 'R.O.': [596, 651, 664], 'Development.': [597, 652, 665], '1993;': [598, 653], '119:': [599, 654], '1079-1091Crossref': [600], 'Additionally,': [604], 'receptor': [609], 'one': [611, 1035], 'several': [613], 'receptors': [615, 3296], '(12Pytela': [616], 'R.': [617, 833, 1067, 1071, 1073, 1119, 1213, 1217, 1219, 1246, 1405, 1409, 1411, 3256], 'Pierschbacher': [618], 'M.D.': [619], 'Ruoslahti': [620], 'Cell.': [622, 816, 1095, 1318, 3239], '1985;': [623, 1651], '40:': [624], '191-198Abstract': [625], '(688)': [631], 'Scholar),': [633], 'also': [634, 784, 2298], 'exhibit': [640], 'some': [641, 2129, 2294, 2571], 'cardiac': [644], 'defects': [645], '(13Yang': [646], 'J.T.': [647, 662], '1093-1105Crossref': [655], '14Goh': [659], 'K.L.': [660], 'Yang': [661], '124:': [667], '4309-4319PubMed': [668], 'This': [671, 1515], 'circumstantial': [672], 'evidence': [673, 1485], 'suggests': [674, 3897], 'roles': [676], 'its': [680, 693, 1038, 3542, 4212], 'receptor,': [681], 'angiogenesis.': [685, 1026, 3397], 'We': [686], 'have': [687, 1029, 1180], 'recently': [688], 'shown': [689, 1335, 3399], 'α5β1and': [692], 'ligand': [694, 1039, 1306, 3543], 'are': [696, 1369, 2158, 2462, 4223, 4279], 'expressed': [697], 'at': [698, 1794, 1807, 1853, 1939, 1961, 2036, 2125, 2135, 2142, 2362, 2632, 2712, 2739, 2755, 2767, 2780, 2919, 3021, 3085], 'significantly': [699], 'increased': [700], 'levels': [701, 3527, 4166], 'neovessels': [703], 'induced': [704, 935, 3299], 'tumors': [710], '(15Kim': [711, 753, 958, 1987, 2185, 2481, 3186, 3321, 3859], 'Bell': [713, 755, 960, 1989, 2187, 2483, 3188, 3323, 3596, 3704, 3861], 'K.': [714, 756, 961, 1990, 2188, 2484, 3189, 3324, 3597, 3705, 3862], 'Mousa': [715, 757, 962, 1991, 2189, 2485, 3190, 3325, 3598, 3706, 3863], 'S.A.': [716, 758, 963, 1992, 2190, 2486, 3191, 3326, 3599, 3707, 3864], 'Varner': [717, 759, 913, 964, 990, 1993, 2191, 2487, 3192, 3327, 3353, 3600, 3708, 3865], 'Am.': [719, 761, 966, 1995, 2193, 2489, 3194, 3283, 3329, 3602, 3710, 3867], 'Pathol.': [721, 763, 968, 1997, 2195, 2491, 3196, 3285, 3331, 3604, 3712, 3869], '2000;': [722, 764, 969, 1998, 2196, 2492, 3197, 3332, 3605, 3713, 3870], '156:': [723, 765, 970, 1999, 2197, 2493, 3198, 3333, 3606, 3714, 3871], '1345-1346Abstract': [724, 766, 971, 2000, 2198, 2494, 3199, 3334, 3607, 3715, 3872], '(558)': [732, 774, 979, 2008, 2206, 2502, 3207, 3342, 3615, 3723, 3880], 'Notably,': [735, 4369], 'antibody,': [736, 2075], 'peptide,': [737, 2962], 'small': [739, 1722, 1736, 3573], 'molecule': [740, 1723, 1737, 3574], 'antagonists': [741, 778, 1004, 3162, 3292, 3575, 3894, 4244, 4263], 'block': [747, 933, 1011, 3169, 3297, 3579, 3857, 3950], 'factor-': [749], 'tumor-induced': [751, 3173], 'another': [780], 'fibronectin-binding': [781], 'integrin,': [782], 'αvβ3,': [783, 3563], 'inhibit': [785, 1041, 1337, 3623, 4015, 4255], '(16Brooks': [787], 'P.C.': [788, 803, 829, 852, 908, 985, 2646, 3211, 3226, 3252, 3348], 'Clark': [789, 3212], 'R.A.': [790, 809, 1647, 3213, 3232], 'Science.': [793, 917, 994, 3216, 3357], '264:': [795, 3218], '569-571Crossref': [796, 3219], '(2749)': [799, 3222], '17Brooks': [802, 3225], 'Montgomery': [804, 853, 2647, 3227], 'A.M.P.': [805, 854, 2648, 3228], 'Rosenfeld': [806, 3229], 'M.': [807, 906, 983, 1117, 1244, 3230, 3274, 3276, 3346], 'Reisfeld': [808, 3231], 'Hu': [810, 3233], 'T.': [811, 3234], 'Klier': [812, 3235], '1157-1164Abstract': [819, 3242], '(2184)': [825, 3248], '18Brooks': [828, 3251], 'Stromblad': [830, 3253], 'Klemke': [832, 3255], 'Visscher': [834, 3257], 'Sarkar': [836, 3259], 'F.H.': [837, 3260], 'Clin.': [841, 3264], '96:': [844, 3267], '1815-1822Crossref': [845, 3268], '(757)': [848, 3271], '19Brooks': [851], 'Methods': [857, 2651], 'Mol.': [858, 1093, 1316, 2652], '1999;': [860, 1170, 1297, 1436, 1472, 2654], '129:': [861, 2655], '257-269PubMed': [862, 2656], '20Carron': [865], 'C.P.': [866], 'Meyer': [867], 'D.M.': [868], 'Pegg': [869], 'Engleman': [871], 'V.W.': [872], 'Nickols': [873], 'M.A.': [874], 'Settle': [875], 'S.L.': [876], 'Westlin': [877], 'W.F.': [878], 'Ruminski': [879], 'P.G.': [880], 'Nichols': [881], 'G.A.': [882, 1138, 1265], 'Cancer': [883], 'Res.': [884], '1998;': [885], '1930-1955PubMed': [887], '21Drake': [890], 'C.J.': [891], 'Little': [894], 'C.D.': [895], 'Sci.': [898], '108:': [900], '2655-2661Crossref': [901], '22Friedlander': [905, 982, 3345], 'Brooks': [907, 984, 3347], 'Shaffer': [909, 986, 3349], 'R.W.': [910, 987, 1645, 3350], 'Kincaid': [911, 988, 3351], 'C.M.': [912, 989, 1075, 1221, 1413, 3352], '270:': [919, 996, 3359], '1500-1502Crossref': [920, 997, 3360], '(1225)': [923, 1000, 3363], 'Antagonists': [926, 1500], 'both': [928, 1006, 3413, 3431, 3570], 'these': [930, 951, 1021, 3294, 3311, 3655, 4198, 4362], 'integrins': [931, 952, 1007, 1023, 1046, 1185, 1368, 3312, 3656, 4171], 'substantially': [932, 1010, 3168], '(bFGF)1': [941], 'but': [942, 3302, 3511, 3928, 3987, 4253], 'not': [943, 3303, 3483, 3505, 3512, 3545, 3929, 3949, 3969, 3988, 4081, 4161, 4194, 4248, 4318], 'factor,': [948, 3308], 'suggesting': [949, 3309, 3653], 'regulate': [953], 'similar': [954, 3491], 'pathways': [955, 3320], 'Since': [1003, 4243], 'independently': [1008], 'same': [1013, 3318, 3516, 4096], 'pathway': [1014], 'it': [1017], 'possible': [1019], 'two': [1022], 'interact': [1024], 'Previous': [1027], 'indicated': [1030, 1181], 'occupancy': [1033], 'functions': [1043, 1491], 'other': [1045, 3559, 3991], '(23Blystone': [1047, 1193, 1346, 1385], 'S.D.': [1048, 1158, 1194, 1285, 1347, 1386, 1424, 1460], 'Graham': [1049, 1195, 1348, 1387], 'I.L.': [1050, 1196, 1349, 1388], 'Lindberg': [1051, 1110, 1197, 1237, 1350, 1389], 'F.P.': [1052, 1111, 1198, 1238, 1351, 1390], 'Brown': [1053, 1108, 1165, 1199, 1235, 1292, 1352, 1391, 1431, 1467], 'E.J.': [1054, 1109, 1166, 1200, 1236, 1293, 1353, 1392, 1432, 1468], '127:': [1059, 1205, 1358, 1397], '1129-1137Crossref': [1060, 1206, 1359, 1398], '(222)': [1063, 1209, 1362, 1401], '24Pacifici': [1066, 1212, 1404], 'Roman': [1068, 1214, 1406], 'Kimble': [1070, 1216, 1408], 'Civitelli': [1072, 1218, 1410], 'Brownfield': [1074, 1220, 1412], 'Bizzarri': [1076, 1222, 1414], 'Immunol.': [1079, 1122, 1225, 1249, 1417, 1624], '153:': [1081, 1227, 1419], '2222-2233PubMed': [1082, 1228, 1420], '25Diaz-Gonzales': [1085], 'F.': [1086, 1309], 'Forsyth': [1087, 1310], 'Steiner': [1089, 1312], 'Ginsberg': [1091, 1314], 'M.H.': [1092, 1315], '7:': [1097, 1320], '1939-1951Crossref': [1098, 1321], '(155)': [1101, 1324], '26Imhof': [1104, 1231], 'Weerasinghe': [1106, 1233], 'Hammel': [1112, 1239], 'Piali': [1114, 1241], 'Dessing': [1116, 1243], 'Giesler': [1118, 1245], 'Eur.': [1120, 1247], '27:': [1124, 1251], '3242-3252Crossref': [1125, 1252], '(55)': [1128, 1255], '27Simon': [1131, 1258], 'K.O.': [1132, 1259], 'Nutt': [1133, 1260], 'E.M.': [1134, 1261], 'Abraham': [1135, 1262], 'D.G.': [1136, 1263], 'Rodan': [1137, 1264], 'Duong': [1139, 1266], '272:': [1145, 1272], '29380-29389Abstract': [1146, 1273], '(85)': [1154, 1281], '28Blystone': [1157, 1284, 1423], 'Slater': [1159, 1286, 1425, 1461], 'S.E.': [1160, 1287, 1426, 1462], 'Williams': [1161, 1288, 1427, 1463], 'M.P.': [1162, 1289, 1428, 1464], 'Crow': [1163, 1290, 1429, 1465], 'M.T.': [1164, 1291, 1430, 1466], '145:': [1171, 1298, 1437, 1473], '889-897Crossref': [1172, 1299, 1438, 1474], '(106)': [1175, 1302, 1441, 1477], 'These': [1178, 3639, 3973], 'cross-talk': [1183, 1374], 'between': [1184, 1366], 'properties': [1188], 'integrin-mediated': [1190], 'Scholar)': [1304, 1616, 1628], 'binding': [1307], '(25Diaz-Gonzales': [1308], 'For': [1327, 1444], 'example,': [1328, 1445], 'has': [1333], 'been': [1334, 3066], 'phagocytosis': [1341], 'Interactions': [1365], 'individual': [1367], 'known': [1370], 'cross-talk.': [1372], 'Integrin': [1373, 1719], 'appears': [1375], 'depend': [1377], 'actions': [1380], 'signal': [1382, 4321], 'transduction': [1383, 4322], 'molecules': [1384], 'suppression': [1448], 'α5β1-mediated': [1450], 'dependent': [1453, 1521], 'calcium/calmodulin-dependent': [1455], 'II': [1458], '(28Blystone': [1459], 'report,': [1482], 'we': [1483, 4257], 'provide': [1484], 'α5β1suppress': [1503], 'focal': [1505, 4241, 4268, 4306, 4332, 4339], 'contact': [1506, 4269], 'formation': [1507, 4236, 4270, 4372], 'inhibiting': [1512], 'cellular': [1513, 3647, 3951, 4058, 4221], 'attachment.': [1514], 'inhibition': [1516, 3885, 4282], 'activation': [1524], 'blocked': [1533, 1798, 2040, 2236, 2730, 2758, 3074, 3412, 3447, 3486, 3508], 'PKA.': [1537, 3009], 'Culture': [1538, 2707], 'media': [1539], 'reagents': [1541], 'were': [1542, 1549, 1572, 1585, 1629, 1664, 1697, 1703, 1750, 1771, 1781, 1811, 1847, 1860, 1880, 1904, 1943, 1965, 1983, 2023, 2116, 2180, 2219, 2235, 2250, 2297, 2330, 2348, 2367, 2394, 2435, 2448, 2477, 2514, 2559, 2591, 2596, 2630, 2663, 2678, 2701, 2709, 2727, 2744, 2784, 2812, 2838, 2914, 2949, 2971, 3019, 3027, 3034, 3058, 3080, 3114, 3144, 3376, 3474, 4010], 'Irvine': [1544], 'Scientific': [1545], '(Irvine,': [1546], 'CA).': [1547, 1590, 1684, 1708, 1756], 'HUVECS': [1548, 1810, 2248, 2783, 4205], 'maintained': [1550], 'M199': [1552, 2262], 'medium': [1553, 1711, 2170, 2263, 2821, 3047], 'containing': [1554, 2097, 2264, 2885], 'sodium': [1555], 'bicarbonate,': [1556], 'HEPES,': [1557], 'heparin,': [1558], 'supplement,': [1562], '20%': [1563], 'fetal': [1564], 'serum,': [1566], 'gentamycin.': [1568], 'Fibronectin': [1569], 'collagen': [1571, 2032, 3967, 4030, 4127], 'Collaborative': [1574], 'Biomedical': [1575], 'Products': [1576], '(Bedford,': [1577], 'MA).': [1578, 1767], 'Human': [1579], '120-kDa': [1580], 'chymotryptic': [1581], 'fragments': [1582], 'purchased': [1586, 1671, 1678, 1704, 1751, 1762, 1772], 'Chemicon': [1588], '(Temecula,': [1589], 'Vitronectin': [1591], 'purified': [1593], 'denaturation/heparin': [1595], 'affinity': [1596, 3538], 'column': [1597], 'standard': [1598, 2173, 2470, 2694], 'procedures.': [1599], 'LM609': [1600], '(29Cheresh': [1601], 'Spiro': [1603], 'R.C.': [1604], '1987;': [1608], '262:': [1609], '17703-17711Abstract': [1610], 'W6/32': [1618], '(30Brodsky': [1619], 'F.M.': [1620], 'Parham': [1621], '1992;': [1625], '128:': [1626], '129-135Google': [1627], 'Dr.': [1632, 1639], 'David': [1633], 'Cheresh.': [1634], 'AP3': [1635], 'Peter': [1640], 'Newman': [1641], '(31Newman': [1642], 'P.J.': [1643], 'Allen': [1644], 'Kahn': [1646], 'Kunicki': [1648], 'T.J.': [1649], 'Blood.': [1650], '65:': [1652], '227-232Crossref': [1653], 'Anti-α5β1': [1657, 3485, 3507], 'blocking': [1659, 2061, 2067, 2074, 2080, 2532, 3406], 'antibodies': [1660, 1702, 1875, 1926, 2286, 2751, 2778, 2831, 3407, 3423, 3619, 3849, 3920, 3931, 3944, 4122, 4137, 4178], '(JBS5)': [1661], 'anti-α2β1antibodies': [1663], 'generously': [1665], 'Chemicon.': [1668, 1699], 'Anti-vinculin': [1669], 'Seratec': [1673], '(Washington,': [1674], 'DC).': [1675], 'Anti-paxillin': [1676], 'Transduction': [1680], 'Laboratories': [1681], '(San': [1682], 'Diego,': [1683], 'Anti-fibronectin': [1685], 'cell-binding': [1686, 3853, 3924], 'peptide': [1687, 1694, 2544, 2549], 'monoclonal': [1688, 1695, 1920], 'antibody': [1689, 1696, 2062, 2068, 2081, 2087, 2538, 3571], '(784A2A6)': [1690], 'anti-fibronectin': [1692, 3943, 4121], 'N-terminal': [1693], 'Cross-absorbed': [1700], 'secondary': [1701, 3141], 'fromBIOSOURCE': [1705], 'International': [1706], '(Camarillo,': [1707], 'OCT': [1709], 'embedding': [1710], 'obtained': [1713], 'Baxter': [1715], '(McGraw': [1716], 'Park,': [1717], 'IL).': [1718], 'nonpeptide': [1721, 1735], 'antagonist': [1724], 'SJ749': [1725, 2290], 'had': [1726, 1739, 2384, 2427, 3065, 3427, 3457], 'following': [1728, 1741], 'structure:': [1729, 1742], '(S)-2-[(2,4': [1730], '6-trimethylphenyl)': [1731], 'sulfonyl]amino-3-[7-benzyloxycarbonyl-8-(2-pyridinylaminomethyl)-1-oxa-2,7-diazaspiro-(4,4)-non-2-en-3-yl]carbonylamino]propionic': [1732], 'acid.': [1733], 'Control': [1734], 'XU065': [1738], '3-[(3-[(4-amidinophenyl)oxy]isoxazol-5-yl]carboxamido]-2(S)(butoxycarbonylamino)propionic': [1743], 'acid': [1744, 2984], 'methyl': [1745], 'ester.': [1746], 'Ten-day-old': [1747], 'chicken': [1748, 2512, 3176], 'eggs': [1749, 2513], 'McIntyre': [1753], 'Poultry': [1754], '(Ramona,': [1755], 'Basic': [1757], 'Genzyme,': [1764], 'Inc.': [1765, 1776, 2876], '(Cambridge,': [1766], 'assay': [1769, 2932, 2954], 'kits': [1770], 'Life': [1774, 2874], 'Technologies,': [1775, 2875], 'Round': [1777], '1-mm-thick': [1778], 'glass': [1779], 'coverslips': [1780], 'coated': [1782, 1857, 2024, 2220, 2710, 2745, 3067], 'with': [1783, 1799, 1831, 1906, 2025, 2041, 2151, 2221, 2237, 2378, 2400, 2407, 2516, 2606, 2715, 2746, 2796, 2840, 2845, 2980, 3068, 3075, 3091, 4012, 4062, 4175, 4234], '1': [1784, 1792, 1851, 1937, 1959, 2034, 2051, 2232, 2246, 2523, 2737, 2765, 3402, 3442, 3452, 3470, 3585], 'μg/ml': [1785, 1867, 1908, 1912, 1924, 1953, 2027, 2058, 2065, 2071, 2077, 2085, 2223, 2284, 2326, 2337, 2345, 2524, 2717, 2720, 2724, 2748, 2774, 2827, 2858, 2862, 3055], 'fibronectin,': [1786, 2029, 2224, 2721, 3421, 3927, 4027], 'vitronectin,': [1787, 2028, 2225, 3069, 4028], 'collagen,': [1788, 2227, 3070, 3954], 'poly-l-lysine': [1790], 'h': [1793, 1806, 1852, 1938, 1960, 2035, 2233, 2361, 2568, 2738, 2754, 2766, 3084, 3500], 'room': [1795, 1940, 1962], 'temperature,': [1796], 'then': [1797, 1848, 1881, 2395, 3120, 3154, 4019], '3%': [1800, 2610, 2732, 2760], '2': [1805, 1836, 1839, 2102, 2105, 2753, 2801, 2804, 3946, 3964, 4046, 4086, 4144], '37': [1808, 1854, 2037, 2126, 2363, 2740, 2756, 2768, 3086], '°C.': [1809, 2127, 2364, 2741, 2782, 2921], 'removed': [1812, 2368], 'culture': [1814, 1821, 2019, 2452, 3037, 3046, 3062], 'dishes': [1815, 2020, 2121, 3038], 'trypsizination,': [1817], 'washed': [1818, 1882, 1945, 1967, 2728, 2839, 2978], 'serum-free': [1820, 3045], 'medium,': [1822], 'resuspended': [1824, 2787, 3043], "Hanks'": [1826, 2093], 'balanced': [1827, 2094, 2792], 'salt': [1828, 2095, 2793], 'solution': [1829, 2096, 2794], 'supplemented': [1830, 2795], '10': [1832, 1952, 2288, 2661, 2719, 2723, 2773, 2797, 2894, 2937], 'mmHEPES,': [1833, 2798], 'pH': [1834, 2799, 2852, 2892], '7.4,': [1835, 2800], 'mm': [1837, 1842, 2103, 2106, 2111, 2114, 2268, 2271, 2278, 2802, 2807, 2850, 2855, 2890, 2895], 'MgCl2,': [1838, 2104, 2272, 2803, 2896], 'mmCaCl2,': [1840, 2805], '0.2': [1841, 1911, 2113, 2277, 2806], 'MnCl2,': [1843, 2279, 2808], '1%': [1844, 2098, 2265, 2809, 2981], 'BSA.': [1845], 'Cells': [1846, 1859, 2347, 2382, 2811, 3057, 3079], 'incubated': [1849, 1861, 1905, 1950, 2299, 2771, 3081, 3121, 3145], '°C': [1855, 2038, 2714, 3087], 'coverslips.': [1858], '25': [1866, 2057, 2064, 2070, 2076, 2084, 2283, 2310, 2541, 2552, 2555, 2747, 2826, 2857, 2861], 'anti-α5β1,': [1868], 'anti-αvβ3,': [1869], 'anti-αvβ5,': [1870], 'control': [1871, 2086, 2168, 2537, 2548, 2777, 2830, 4356], 'antibodies,': [1872, 1910, 1914, 1921, 3136], 'no': [1874, 2229, 3458], '60': [1877, 2835], 'min.': [1878, 1902, 2836], 'Coverslips': [1879, 1903, 1942, 1964], 'remove': [1884, 2418], 'unbound': [1885], 'cells,': [1886, 4072, 4111], 'fixed': [1887, 2396], '5': [1889, 2026, 2222, 2716, 2854, 2917], 'min': [1890, 2124, 2399, 2405, 2918, 4291], '3.7%': [1892, 2401], 'paraformaldehyde': [1893, 2402, 2611], 'permeabilized': [1895], '0.3%': [1897], 'Triton': [1898], 'X-100': [1899], '3': [1901, 4359], '1.25': [1907], 'anti-paxillin': [1909], 'anti-vinculin': [1913], '1:500': [1915], 'dilution': [1916], 'anti-integrin': [1918, 3124], 'β3': [1919, 3127, 4170, 4312], '2.7': [1923], 'anti-phosphotyrosine': [1925], '20': [1928, 2123, 2143, 2307, 2325, 2583], 'mg/ml': [1929, 2898], 'phosphate-buffered': [1934, 1947, 1969, 2048, 2243, 2613, 2841], 'saline': [1935, 1948, 2049, 2244, 2558, 2614, 2842], 'temperature.': [1941, 1963], 'well': [1944, 1966, 2281, 3565, 4304], 'goat': [1954, 2749], 'anti-mouse': [1955, 2750], 'fluorescein': [1956], 'isothiocyanate': [1957], 'saline,': [1970], 'mounted': [1972], 'Gelvatol,': [1974], 'prior': [1975, 2615, 3088], 'confocal': [1977], 'fluorescent': [1978], 'microsopy.': [1979], 'adhesion': [1981, 2090, 2163, 2789, 3295, 3415, 3448, 3513, 4333, 4340], 'assays': [1982, 2179, 2476], 'performed': [1984, 2148, 2181, 2331, 2478, 2671, 2702, 3028], 'described': [1986, 2184, 2480], 'brief,': [2012], 'wells': [2014], '48-well': [2016], 'non-tissue': [2017], 'culture-treated': [2018], '(Costar,': [2021, 2217], 'Inc.)': [2022, 2218], 'Del-1,': [2030, 2226], '2%': [2042, 2238, 2409], 'heat-denatured': [2043], 'h.': [2052, 2247], 'Fifty': [2053, 3096], 'thousand': [2054], '(JBS5),': [2063], 'anti-αvβ3function': [2066], '(LM609),': [2069], 'anti-α2β1': [2072, 4132], 'anti-β1': [2078], '(P4C10),': [2082], '(W6/32)': [2088], 'buffer': [2091, 2260, 2790, 2848], '(Hepes-buffered': [2092, 2261], 'albumin,': [2101], 'CaCl2,': [2107, 2269], 'either': [2109, 2274, 3961], '0': [2110, 2275], 'MnCl2)': [2115], 'allowed': [2117, 2349], 'adhere': [2119], 'experiments,': [2130, 2295], 'used': [2134, 2141, 2664], '500': [2136, 2320, 2587], 'μm': [2137, 2289, 2308, 2321, 2542, 2574, 2584, 2588, 2901, 2912, 2938], 'forskolin': [2139], 'μg/ml.': [2144], 'Each': [2145, 2668], 'experiment': [2146, 2669], 'triplicate,': [2150], 'triplicate': [2152, 3013], 'samples': [2153, 2948, 2967, 3014], 'per': [2154, 2444, 2665, 2690], 'condition.': [2155], 'data': [2157, 2461], 'presented': [2159, 2463], 'percentage': [2161], 'exhibited': [2164], 'positive': [2167], '(adhesion': [2169], 'alone)': [2171], '±': [2172, 2469, 2693], 'error': [2174, 2471, 2695], 'mean.': [2177, 2474, 2698], 'Migration': [2178, 4125, 4146], 'essentially': [2182], 'lower': [2210, 2357, 2388], 'side': [2211, 2389], '8-μm': [2213], 'pore': [2214], 'Transwell': [2215, 2392], 'inserts': [2216, 2257], '(25,000)': [2249], 'added': [2251, 2592], 'upper': [2254, 2354, 2371, 2376], 'chamber': [2255, 2358, 2372], 'BSA,': [2266, 2899], '1.8': [2267, 2270], 'various': [2285], 'XU065.': [2292], 'final': [2304, 2886], 'concentrations': [2305, 2887], 'H8,': [2309, 2575], 'μmautocamtide': [2311], '2,': [2312, 3496, 4066], '50': [2313, 2573, 2579, 2889, 2900], 'nm': [2314, 2577, 2580], 'calphostin': [2315, 2581], 'C,': [2316, 2582], '48': [2318], 'nmH89,': [2319], 'cAMP,': [2323], 'forskolin.': [2327], 'Some': [2328], 'experiments': [2329, 3018, 3375], '200': [2336, 2344, 3054], 'cycloheximide,': [2338], 'after': [2339, 3495, 4292], '4-h': [2341], 'preincubation': [2342], 'cycloheximide.': [2346, 3056], 'migrate': [2351, 4025], '4': [2360, 2713, 2781, 3083], 'Non-migratory': [2365], 'wiping': [2374], 'surface': [2377, 3636, 3665], 'absorbent': [2380], 'tip.': [2381], 'migrated': [2385, 2428], 'insert': [2393, 2457], '15': [2398, 2404], 'crystal': [2410, 2420], 'violet': [2411], 'solution.': [2412], 'After': [2413], 'extensive': [2414], 'water': [2415], 'washing': [2416], 'excess': [2419], 'violet,': [2421], 'number': [2423, 2465, 2684], '(to': [2429], 'bottom': [2431], 'insert)': [2434], 'counted': [2436, 2631], 'three': [2438, 2675, 3023], 'representative': [2439], 'high': [2440, 3526], 'power': [2441], '(200×)': [2442], 'fields': [2443], 'insert.': [2445], 'No': [2446], 'found': [2449], 'dish': [2453], 'placed.': [2459], 'migrating': [2468], 'Briefly,': [2505, 2877], 'membranes': [2507], '(CAMs)': [2508], '10-day-old': [2510], 'embryonated': [2511], 'stimulated': [2515, 2620], 'cortisone': [2517], 'acetate-pretreated': [2518], 'filter': [2519, 2565], 'discs': [2520], 'saturated': [2521], 'bFGF': [2525, 3301], 'saline.': [2527], 'Twenty-five': [2528], 'μg': [2529], '(25': [2539], 'μl),': [2540], 'cyclic': [2543], '(CRRETAWAC)': [2545], 'scrambled': [2547], '(CATAERWRC)': [2550], 'μl,': [2553], 'μl': [2556, 2966], 'applied': [2560], 'factor-saturated': [2564], 'disc': [2566, 2629], '24': [2567], 'later.': [2569], 'cases,': [2572], '480': [2576], 'H89,': [2578], 'CAMs.': [2594], 'CAMs': [2595], 'harvested': [2597], '4th': [2600], 'day': [2601], 'stimulation': [2603], 'fixation': [2605], 'drop': [2608], 'excision': [2617], 'area.': [2621], 'Blood': [2622], 'vessel': [2623, 2687], 'branch': [2624, 2688], 'points': [2625, 2689], '5-mm': [2628], 'magnification': [2634], '30': [2636, 2920, 4290], 'under': [2637], 'fiber': [2638, 4371], 'optic': [2639], 'illumination': [2640], 'blinded': [2643], 'fashion': [2644], '(19Brooks': [2645], 'At': [2659], 'least': [2660, 3022], 'embryos': [2662, 3177], 'treatment': [2666, 2691, 4154], 'group.': [2667], 'minimum': [2673], 'times.': [2676, 3024], 'Data': [2677], 'evaluated': [2679, 4020], 'terms': [2681], 'average': [2683], 'group': [2692], 'Statistical': [2699, 3025], 'analyses': [2700, 3026], 'using': [2703, 2870, 3029], "Student's": [2704, 3030], 't': [2705, 3031], 'test.': [2706, 3032], 'plates': [2708, 2743, 2819, 3063], 'overnight': [2711, 2779], 'poly-l-lysine,': [2718], 'vitronectin.': [2725, 3909], 'Plates': [2726, 2837], 'Additional': [2742], '°C,': [2757, 2769], 'trypsinized': [2785], "(Hanks'": [2791], 'BSA).': [2810], 'plated': [2813, 3059], 'antibody-coated': [2818], '(W6/32,': [2832], 'anti-MHC)': [2833], 'extracted': [2844], 'cold': [2846], 'extraction': [2847], '(50': [2849], 'Tris,': [2851, 2891], '7.5,': [2853, 2893], 'EDTA,': [2856], 'aprotinin,': [2859], 'leupeptin).': [2863], 'Protein': [2864], 'activity': [2867, 2942, 3011], 'assessed': [2869], 'kit': [2872], 'equal': [2878], 'volumes': [2879], 'lysate': [2881, 3102], 'reaction': [2883, 2969], 'mixture': [2884], '0.25': [2897], 'kemptide': [2902], '(protein': [2903], 'A-specific': [2905], 'substrate),': [2906], '3000': [2907], 'Ci/mmol': [2908], '[γ-32P]ATP,': [2909], '100': [2911], 'ATP': [2913], 'combined': [2915], 'Total': [2922], 'each': [2925, 3101], 'sample': [2926, 3004, 3094], 'measured': [2928, 3016, 3494, 4172], 'performing': [2930, 2952], 'cAMP.': [2939], 'Background': [2940], 'test': [2944, 3003], 'total': [2946, 3008], 'determined': [2950, 2990], 'inhibitor': [2961], 'PKI-(6–22)': [2963], 'amide.': [2964], 'Twenty': [2965], 'mixtures': [2970], 'spotted': [2972], 'onto': [2973, 3183], 'phosphocellulose': [2974], 'discs,': [2975], 'air-dried,': [2976], 'repeatedly': [2979], '(v/v)': [2982], 'phosphoric': [2983], 'water.': [2986], 'Incorporated': [2987], 'radioactivity': [2988], 'scintillation': [2992], 'counting.': [2993], 'Activated': [2994], 'calculated': [2997], 'ratio': [3000], 'pmol/min': [3002, 3007], 'repeated': [3020], 'HUVECs': [3033, 3419], 'detached': [3035], 'trysinization,': [3040], 'washed,': [3041], 'absence': [3052, 3520], 'albumin.': [3078], 'lysis': [3090], 'boiling': [3092], 'SDS': [3093], 'buffer.': [3095], 'micrograms': [3097], 'electrophoresed': [3104], '6%': [3106], '10%': [3108], 'SDS-polyacrylamide': [3109], 'gels.': [3110], 'separated': [3112], 'proteins': [3113, 4334], 'electrophoretically': [3115], 'transferred': [3116], 'nitrocellulose': [3118], 'anti-fibronectin,': [3123], 'α5': [3125, 4168], 'cytoplasmic': [3128], 'tail,': [3129], 'anti-protein': [3131], 'catalytic': [3134], 'subunit': [3135], 'followed': [3137], 'horseradish': [3139, 3151], 'peroxidase-conjugated': [3140], 'antibodies.': [3142], 'Blots': [3143], 'chemiluminescent': [3148], 'substrate': [3149], 'peroxidase': [3152], 'exposed': [3155], 'film.': [3157], 'show': [3160], 'αvβ3can': [3167], 'skin': [3181], 'transplanted': [3182], 'SCID': [3184], '16Brooks': [3210], 'Scholar,32Christofidou-Solomidou': [3273], 'Bridges': [3275], 'Murphy': [3277], 'Albelda': [3279], 'DeLisser': [3281], 'H.M.': [3282], '151:': [3287], '975-983PubMed': [3288], 'Furthermore,': [3291], 'may': [3313, 3657, 3904], 'cooperate': [3314], 'regulating': [3316], 'angiogenic': [3319], 'To': [3366, 3993], 'evaluate': [3367], 'interactions': [3369], 'αvβ3in': [3373], 'designed': [3377], 'examine': [3379], 'contributions': [3381], 'vitro,': [3387], 'essential': [3394], 'feature': [3395], 'As': [3398], 'Fig.': [3401], '(A': [3403], 'andB),': [3404], 'selective': [3408], 'against': [3424, 3621, 3922, 3933], 'little': [3428], 'effect.': [3429], 'Surprisingly,': [3430], 'anti-αvβ3': [3434, 3446], 'inhibited': [3435, 3917, 4038, 4082, 4093], '(Fig.': [3441, 3451, 3469, 3584, 3895, 3945, 3963, 4045, 4065, 4085, 4143, 4358], 'C),': [3443], 'yet': [3444], 'only': [3445], 'D).': [3453], 'impact': [3459, 4249], 'collagen-mediated': [3461], 'migration,': [3463, 4256], 'α2β1': [3468], 'E).': [3471, 4087, 4145], 'Similar': [3472], 'results': [3473, 3640, 3974, 4052, 4199], 'observed': [3475], 'adult': [3477], 'dermal': [3478], 'microvascular': [3479], '(data': [3482, 3504, 3544, 3968, 4160, 4193, 4317], 'shown).': [3484, 3506, 3546, 4162, 4195, 4319], 'αvβ3−mediated': [3487], 'extents': [3492], 'when': [3493], '4,': [3497], '18': [3499], 'incubation': [3502], 'time': [3503, 4325], 'extent': [3517, 4097], '(200': [3528], 'μm)': [3529], 'Mn2+,': [3531], 'divalent': [3533], 'cation': [3534], 'enhances': [3536], 'required': [3551], 'substrates': [3560], 'F)': [3586], 'affecting': [3588], '(Fig.1': [3591], 'C;': [3592], 'Ref.': [3593], '15Kim': [3594, 3702], 'Thus,': [3618], 'directed': [3620, 3850, 3921, 3932], 'antagonizing': [3628], 'ligation,': [3630], 'rather': [3631], 'than': [3632, 4354], 'cross-linking': [3634], 'molecules.': [3638], 'α5β1selectively': [3644], 'impacts': [3645], 'αvβ3-dependent': [3651], 'adhesion,': [3652], 'cooperative': [3661], 'manner': [3662], 'cells.': [3668, 4104], 'readily': [3671], 'secrete': [3672], '(8Clark': [3676], 'fact,': [3727, 4164], 'cell-derived': [3729, 3902], 'specifically': [3732, 3984], 'accumulates': [3733], 'tumor-associated': [3735], 'suggest': [3847, 3975, 4200], 'domain': [3854, 3925], 'indirect': [3884], '1)': [3896], 'possibility': [3899], 'influence': [3905], 'Indeed,': [3910], 'partially': [3916], 'function-blocking': [3919], 'N': [3935], 'terminus': [3936], '(Fig.2': [3939, 4123], 'A).': [3940, 4360], 'B)': [3947], 'do': [3948, 4247, 4254], 'even': [3955], 'though': [3956], 'cultured': [3959], 'C)': [3965], 'shown)': [3970], 'synthesize': [3971], 'cell-secreted': [3982], 'αvβ3function': [3986], 'integrins.': [3992], 'determine': [3994], 'further': [3995], 'whether': [3996], 'secreted': [4003], 'αvβ3function,': [4007], 'treated': [4011, 4101, 4180], 'cycloheximide': [4013, 4040], 'synthesis': [4017, 4034, 4051], 'abilities': [4023], 'substrates.': [4031], 'pretreatment': [4041], 'C).': [4047], 'Inhibition': [4048], 'overall': [4055], 'reduction': [4056], 'rates': [4060], 'compared': [4061], 'untreated': [4063, 4071, 4103, 4110, 4141, 4158, 4182], 'D–F).': [4067], 'contrast': [4069, 4108], 'cycloheximide-treated': [4076, 4114, 4139, 4156], 'anti-α5β1antibodies': [4084], 'However,': [4088], 'anti-αvβ3antibodies': [4099], 'addition,': [4106], 'refractory': [4119], 'F).': [4124], 'equally': [4129, 4150], 'sensitive': [4130, 4151], 'insensitive': [4134], 'expression': [4165, 4188], 'immunoblotting': [4174], 'anti-cytoplasmic': [4176], 'tail': [4177], 'remains': [4184], 'unchanged': [4185], 'does': [4187], 'Taken': [4196], 'together,': [4197], 'synthesized': [4203], 'based': [4210], 'ability': [4213], 'ligate': [4215], 'Temporal': [4218], 'prerequisites': [4219], 'spreading': [4227, 4266, 4286], 'matrix,': [4233], 'concomitant': [4235], 'stress': [4238, 4299, 4370], 'fibers': [4239, 4300], 'adhesions.': [4242], 'examined': [4258], 'effect': [4260], 'establish': [4272], 'earliest': [4274], 'events': [4277], 'affected': [4280], 'During': [4285], '(within': [4289], 'initial': [4293], 'attachment),': [4295], 'form': [4298], '(Fig.3': [4301, 4313], 'A)': [4302], 'adhesions': [4307], 'incorporating': [4308], 'paxillin,': [4309], 'vinculin,': [4310], 'B),': [4314], 'phosphotyrosine': [4316], 'Integrin-mediated': [4320], 'tyrosine': [4329], 'phosphorylation': [4330], 'paxillin': [4337], 'kinase.': [4341], 'α5β1antagonists,': [4347], 'generally': [4350], 'appear': [4351], 'less': [4352], 'polarized': [4353], 'Instead,': [4361], 'acquire': [4364], 'rounded,': [4366], 'pancake-like': [4367], 'morphology.': [4368], 'i': [4373]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1998709931', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-09T02:45:19.467033', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
