Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1998514790', 'doi': 'https://doi.org/10.1111/j.1365-2125.1981.tb01097.x', 'title': 'Pethidine clearance during continuous intravenous infusions in postoperative patients.', 'display_name': 'Pethidine clearance during continuous intravenous infusions in postoperative patients.', 'publication_year': 1981, 'publication_date': '1981-01-01', 'ids': {'openalex': 'https://openalex.org/W1998514790', 'doi': 'https://doi.org/10.1111/j.1365-2125.1981.tb01097.x', 'mag': '1998514790', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7213505', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1401696'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2125.1981.tb01097.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13842274', 'display_name': 'British Journal of Clinical Pharmacology', 'issn_l': '0306-5251', 'issn': ['0306-5251', '1365-2125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1401696?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068848951', 'display_name': 'K. L. Austin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802931750', 'display_name': 'Flinders Medical Centre', 'ror': 'https://ror.org/020aczd56', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802931750']}, {'id': 'https://openalex.org/I170239107', 'display_name': 'University of South Australia', 'ror': 'https://ror.org/01p93h210', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I170239107']}, {'id': 'https://openalex.org/I169541294', 'display_name': 'Flinders University', 'ror': 'https://ror.org/01kpzv902', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I169541294']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'KL Austin', 'raw_affiliation_strings': ['Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, S.A. 5042, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, S.A. 5042, Australia', 'institution_ids': ['https://openalex.org/I2802931750', 'https://openalex.org/I170239107', 'https://openalex.org/I169541294']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056857426', 'display_name': 'J. V. Stapleton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802931750', 'display_name': 'Flinders Medical Centre', 'ror': 'https://ror.org/020aczd56', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802931750']}, {'id': 'https://openalex.org/I170239107', 'display_name': 'University of South Australia', 'ror': 'https://ror.org/01p93h210', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I170239107']}, {'id': 'https://openalex.org/I169541294', 'display_name': 'Flinders University', 'ror': 'https://ror.org/01kpzv902', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I169541294']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'JV Stapleton', 'raw_affiliation_strings': ['Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, S.A. 5042, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, S.A. 5042, Australia', 'institution_ids': ['https://openalex.org/I2802931750', 'https://openalex.org/I170239107', 'https://openalex.org/I169541294']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029477822', 'display_name': 'Laurence E. Mather', 'orcid': 'https://orcid.org/0000-0001-8174-7752'}, 'institutions': [{'id': 'https://openalex.org/I2802931750', 'display_name': 'Flinders Medical Centre', 'ror': 'https://ror.org/020aczd56', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802931750']}, {'id': 'https://openalex.org/I170239107', 'display_name': 'University of South Australia', 'ror': 'https://ror.org/01p93h210', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I170239107']}, {'id': 'https://openalex.org/I169541294', 'display_name': 'Flinders University', 'ror': 'https://ror.org/01kpzv902', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I169541294']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'LE Mather', 'raw_affiliation_strings': ['Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, S.A. 5042, Australia'], 'affiliations': [{'raw_affiliation_string': 'Department of Anaesthesia and Intensive Care, Flinders Medical Centre, The Flinders University of South Australia, Bedford Park, S.A. 5042, Australia', 'institution_ids': ['https://openalex.org/I2802931750', 'https://openalex.org/I170239107', 'https://openalex.org/I169541294']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4330, 'currency': 'USD', 'value_usd': 4330, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.64, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.833449, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '11', 'issue': '1', 'first_page': '25', 'last_page': '30'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10436', 'display_name': 'Anesthesia and Sedation Management', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2703', 'display_name': 'Anesthesiology and Pain Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10436', 'display_name': 'Anesthesia and Sedation Management', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2703', 'display_name': 'Anesthesiology and Pain Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Pharmacokinetics of Antibiotics in Critically Ill Patients', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11967', 'display_name': 'Diagnosis and Management of Hyponatremia', 'score': 0.9847, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pethidine', 'display_name': 'Pethidine', 'score': 0.994964}, {'id': 'https://openalex.org/keywords/indocyanine-green', 'display_name': 'Indocyanine green', 'score': 0.65320617}, {'id': 'https://openalex.org/keywords/clearance', 'display_name': 'Clearance', 'score': 0.59279275}, {'id': 'https://openalex.org/keywords/metabolic-clearance-rate', 'display_name': 'Metabolic clearance rate', 'score': 0.56759465}, {'id': 'https://openalex.org/keywords/continuous-infusion', 'display_name': 'Continuous Infusion', 'score': 0.519995}], 'concepts': [{'id': 'https://openalex.org/C2781168792', 'wikidata': 'https://www.wikidata.org/wiki/Q55434', 'display_name': 'Pethidine', 'level': 3, 'score': 0.994964}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.8663588}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.68660855}, {'id': 'https://openalex.org/C2781065829', 'wikidata': 'https://www.wikidata.org/wiki/Q905662', 'display_name': 'Indocyanine green', 'level': 2, 'score': 0.65320617}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6445693}, {'id': 'https://openalex.org/C138944611', 'wikidata': 'https://www.wikidata.org/wiki/Q1163287', 'display_name': 'Clearance', 'level': 2, 'score': 0.59279275}, {'id': 'https://openalex.org/C2909957684', 'wikidata': 'https://www.wikidata.org/wiki/Q1163287', 'display_name': 'Metabolic clearance rate', 'level': 3, 'score': 0.56759465}, {'id': 'https://openalex.org/C147583825', 'wikidata': 'https://www.wikidata.org/wiki/Q620876', 'display_name': 'Body weight', 'level': 2, 'score': 0.437455}, {'id': 'https://openalex.org/C141071460', 'wikidata': 'https://www.wikidata.org/wiki/Q40821', 'display_name': 'Surgery', 'level': 1, 'score': 0.3241134}, {'id': 'https://openalex.org/C126894567', 'wikidata': 'https://www.wikidata.org/wiki/Q105650', 'display_name': 'Urology', 'level': 1, 'score': 0.27169344}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.24256551}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.1696817}, {'id': 'https://openalex.org/C2780820201', 'wikidata': 'https://www.wikidata.org/wiki/Q173235', 'display_name': 'Analgesic', 'level': 2, 'score': 0.1489462}], 'mesh': [{'descriptor_ui': 'D008614', 'descriptor_name': 'Meperidine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007208', 'descriptor_name': 'Indocyanine Green', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007263', 'descriptor_name': 'Infusions, Parenteral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008614', 'descriptor_name': 'Meperidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008614', 'descriptor_name': 'Meperidine', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': False}, {'descriptor_ui': 'D011184', 'descriptor_name': 'Postoperative Period', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2125.1981.tb01097.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S13842274', 'display_name': 'British Journal of Clinical Pharmacology', 'issn_l': '0306-5251', 'issn': ['0306-5251', '1365-2125'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1401696', 'pdf_url': 'https://europepmc.org/articles/pmc1401696?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401696', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7213505', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1401696', 'pdf_url': 'https://europepmc.org/articles/pmc1401696?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.47, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 21, 'referenced_works': ['https://openalex.org/W1910350416', 'https://openalex.org/W1974207620', 'https://openalex.org/W1977860595', 'https://openalex.org/W1981569580', 'https://openalex.org/W1988354766', 'https://openalex.org/W2009782471', 'https://openalex.org/W2025443472', 'https://openalex.org/W2065037721', 'https://openalex.org/W2067167613', 'https://openalex.org/W2072571162', 'https://openalex.org/W211944569', 'https://openalex.org/W2126019146', 'https://openalex.org/W2137187169', 'https://openalex.org/W2292599282', 'https://openalex.org/W2315509859', 'https://openalex.org/W2410359872', 'https://openalex.org/W2415769836', 'https://openalex.org/W4206710014', 'https://openalex.org/W4240245730', 'https://openalex.org/W571870702', 'https://openalex.org/W64096637'], 'related_works': ['https://openalex.org/W4251840438', 'https://openalex.org/W4244040633', 'https://openalex.org/W2403957859', 'https://openalex.org/W2402115726', 'https://openalex.org/W2063988180', 'https://openalex.org/W2058814545', 'https://openalex.org/W2046962851', 'https://openalex.org/W2032335539', 'https://openalex.org/W1998514790', 'https://openalex.org/W1978500857'], 'abstract_inverted_index': {'1': [0], 'Pethidine': [1, 55, 71], 'pharmacokinetics': [2], 'in': [3, 36], 'ten': [4], 'female': [5], 'patients': [6], 'during': [7], 'continuous': [8], 'i.v.': [9], 'infusion': [10], 'for': [11], '32': [12], 'h': [13], 'post-surgery': [14], 'have': [15], 'been': [16], 'determined.': [17], '2': [18], 'The': [19], 'blood': [20], 'clearance': [21, 59, 72], 'of': [22, 88], 'pethidine': [23], '(mean': [24], '+/-': [25, 31], '2.d.)': [26], 'measured': [27], 'directly': [28], 'was': [29, 65], '599': [30], '135': [32], 'ml/min': [33], 'and': [34, 56, 73], 'is': [35], 'marked': [37], 'contrast': [38], 'to': [39], 'some': [40], 'reported': [41, 52], 'values.': [42, 53], '3': [43], 'Other': [44], 'model-dependent': [45], 'pharmacokinetic': [46], 'parameters': [47], 'were': [48, 60, 77], 'consistent': [49], 'with': [50], 'previously': [51], '4': [54], 'indocyanine': [57], 'green': [58], 'correlated': [61], 'but': [62], 'the': [63, 89], 'correlation': [64], 'mediated': [66], 'through': [67], 'body': [68], 'weight.': [69], '5': [70], 'steady': [74], 'state': [75], 'concentration': [76], 'predictable': [78], 'retrospectively': [79], 'from': [80], 'linear': [81], 'multivariable': [82], 'equations': [83], 'involving': [84], 'simple': [85], 'physical': [86], 'characteristics': [87], 'patient.': [90]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1998514790', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-18T19:24:25.675069', 'created_date': '2016-06-24'}