Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1998399279', 'doi': 'https://doi.org/10.1038/nature07984', 'title': 'Irreversibility of mitotic exit is the consequence of systems-level feedback', 'display_name': 'Irreversibility of mitotic exit is the consequence of systems-level feedback', 'publication_year': 2009, 'publication_date': '2009-04-22', 'ids': {'openalex': 'https://openalex.org/W1998399279', 'doi': 'https://doi.org/10.1038/nature07984', 'mag': '1998399279', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19387440', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2817895'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature07984', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2817895?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081646608', 'display_name': 'Sandra López-Avilés', 'orcid': 'https://orcid.org/0000-0002-0498-1331'}, 'institutions': [{'id': 'https://openalex.org/I1292966370', 'display_name': "The Honourable Society of Lincoln's Inn", 'ror': 'https://ror.org/010npae67', 'country_code': 'GB', 'type': 'other', 'lineage': ['https://openalex.org/I1292966370']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Sandra López-Avilés', 'raw_affiliation_strings': ['Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK'], 'affiliations': [{'raw_affiliation_string': 'Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK', 'institution_ids': ['https://openalex.org/I1292966370', 'https://openalex.org/I2801316944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071216512', 'display_name': 'Orsolya Kapuy', 'orcid': 'https://orcid.org/0000-0002-8484-4504'}, 'institutions': [{'id': 'https://openalex.org/I29770179', 'display_name': 'Budapest University of Technology and Economics', 'ror': 'https://ror.org/02w42ss30', 'country_code': 'HU', 'type': 'education', 'lineage': ['https://openalex.org/I29770179']}, {'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB', 'HU'], 'is_corresponding': False, 'raw_author_name': 'Orsolya Kapuy', 'raw_affiliation_strings': ['Budapest University of Technology and Economics, Gellért tér 4, 1521 Budapest, Hungary ,', 'Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK,'], 'affiliations': [{'raw_affiliation_string': 'Budapest University of Technology and Economics, Gellért tér 4, 1521 Budapest, Hungary ,', 'institution_ids': ['https://openalex.org/I29770179']}, {'raw_affiliation_string': 'Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK,', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020843492', 'display_name': 'Béla Novák', 'orcid': 'https://orcid.org/0000-0002-6961-1366'}, 'institutions': [{'id': 'https://openalex.org/I40120149', 'display_name': 'University of Oxford', 'ror': 'https://ror.org/052gg0110', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I40120149']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Béla Novák', 'raw_affiliation_strings': ['Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford OX1 3QU, UK,', 'institution_ids': ['https://openalex.org/I40120149']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073121511', 'display_name': 'Frank Uhlmann', 'orcid': 'https://orcid.org/0000-0002-3527-6619'}, 'institutions': [{'id': 'https://openalex.org/I1292966370', 'display_name': "The Honourable Society of Lincoln's Inn", 'ror': 'https://ror.org/010npae67', 'country_code': 'GB', 'type': 'other', 'lineage': ['https://openalex.org/I1292966370']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Frank Uhlmann', 'raw_affiliation_strings': ['Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK'], 'affiliations': [{'raw_affiliation_string': 'Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK', 'institution_ids': ['https://openalex.org/I1292966370', 'https://openalex.org/I2801316944']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 5.364, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 97, 'citation_normalized_percentile': {'value': 0.920275, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '459', 'issue': '7246', 'first_page': '592', 'last_page': '595'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/mitotic-exit', 'display_name': 'Mitotic exit', 'score': 0.7552575}, {'id': 'https://openalex.org/keywords/polo-like-kinase', 'display_name': 'Polo-like kinase', 'score': 0.6659844}, {'id': 'https://openalex.org/keywords/cyclin-b', 'display_name': 'Cyclin B', 'score': 0.6302563}, {'id': 'https://openalex.org/keywords/cyclin-a', 'display_name': 'Cyclin A', 'score': 0.5325619}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.44668186}, {'id': 'https://openalex.org/keywords/cyclin-a2', 'display_name': 'Cyclin A2', 'score': 0.4191784}], 'concepts': [{'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.7776923}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7623426}, {'id': 'https://openalex.org/C6391034', 'wikidata': 'https://www.wikidata.org/wiki/Q6881916', 'display_name': 'Mitotic exit', 'level': 5, 'score': 0.7552575}, {'id': 'https://openalex.org/C124320809', 'wikidata': 'https://www.wikidata.org/wiki/Q46292', 'display_name': 'Cyclin-dependent kinase', 'level': 4, 'score': 0.7051152}, {'id': 'https://openalex.org/C84815855', 'wikidata': 'https://www.wikidata.org/wiki/Q7225885', 'display_name': 'Polo-like kinase', 'level': 4, 'score': 0.6659844}, {'id': 'https://openalex.org/C9743823', 'wikidata': 'https://www.wikidata.org/wiki/Q5198264', 'display_name': 'Cyclin B', 'level': 5, 'score': 0.6302563}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.62404186}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5448875}, {'id': 'https://openalex.org/C16438837', 'wikidata': 'https://www.wikidata.org/wiki/Q5198260', 'display_name': 'Cyclin A', 'level': 5, 'score': 0.5325619}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.44668186}, {'id': 'https://openalex.org/C28179978', 'wikidata': 'https://www.wikidata.org/wiki/Q5198263', 'display_name': 'Cyclin A2', 'level': 5, 'score': 0.4191784}, {'id': 'https://openalex.org/C120089663', 'wikidata': 'https://www.wikidata.org/wiki/Q59250999', 'display_name': 'Cyclin', 'level': 4, 'score': 0.38665354}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.32578528}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.24081749}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.20518842}, {'id': 'https://openalex.org/C53420372', 'wikidata': 'https://www.wikidata.org/wiki/Q22299157', 'display_name': 'Anaphase', 'level': 4, 'score': 0.100851804}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D025461', 'descriptor_name': 'Feedback, Physiological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008938', 'descriptor_name': 'Mitosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003198', 'descriptor_name': 'Computer Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019926', 'descriptor_name': 'Cyclin B', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019926', 'descriptor_name': 'Cyclin B', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050756', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050756', 'descriptor_name': 'Cyclin-Dependent Kinase Inhibitor Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018844', 'descriptor_name': 'Cyclin-Dependent Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016213', 'descriptor_name': 'Cyclins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016193', 'descriptor_name': 'G1 Phase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029701', 'descriptor_name': 'Saccharomyces cerevisiae Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049490', 'descriptor_name': 'Systems Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nature07984', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S137773608', 'display_name': 'Nature', 'issn_l': '0028-0836', 'issn': ['0028-0836', '1476-4687'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2817895', 'pdf_url': 'https://europepmc.org/articles/pmc2817895?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817895', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19387440', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2817895', 'pdf_url': 'https://europepmc.org/articles/pmc2817895?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 30, 'referenced_works': ['https://openalex.org/W1483030389', 'https://openalex.org/W1506793089', 'https://openalex.org/W1520738779', 'https://openalex.org/W1869411311', 'https://openalex.org/W1967163876', 'https://openalex.org/W1977576010', 'https://openalex.org/W1990368851', 'https://openalex.org/W2010325522', 'https://openalex.org/W2019894624', 'https://openalex.org/W2028984447', 'https://openalex.org/W2037992356', 'https://openalex.org/W2039839254', 'https://openalex.org/W2044750332', 'https://openalex.org/W2060458509', 'https://openalex.org/W2061064014', 'https://openalex.org/W2068022037', 'https://openalex.org/W2075408326', 'https://openalex.org/W2076650991', 'https://openalex.org/W2080252696', 'https://openalex.org/W2084343743', 'https://openalex.org/W2085962516', 'https://openalex.org/W2091501337', 'https://openalex.org/W2091912506', 'https://openalex.org/W2112854488', 'https://openalex.org/W2122842475', 'https://openalex.org/W2147600141', 'https://openalex.org/W2150767223', 'https://openalex.org/W2152589202', 'https://openalex.org/W2153100796', 'https://openalex.org/W2168966628'], 'related_works': ['https://openalex.org/W3100452120', 'https://openalex.org/W3021664116', 'https://openalex.org/W2154019163', 'https://openalex.org/W2137479592', 'https://openalex.org/W2135236253', 'https://openalex.org/W2111132814', 'https://openalex.org/W2034501906', 'https://openalex.org/W2034418667', 'https://openalex.org/W2014957927', 'https://openalex.org/W1991290236'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1998399279', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2025-01-16T14:21:38.217806', 'created_date': '2016-06-24'}