Aryl Ether as a Negishi Coupling Partner: An Approach for Constructing CC Bonds under Mild Conditions

Name: Work Video:
Duration: 3 min 30 s
Description: An etheric Negishi coupling: The first cross-coupling reaction between aryl alkyl ethers and dianion-type zincate reagents to afford biaryl compounds through selective cleavage of the etheric C(sp2)O bond was developed. Dianion-type zincates showed excellent reactivity toward the aromatic ethers under mild conditions, with good functional group compatibility (see scheme).
Chao Wang; T. Ozaki; Ryo Takita; Masanobu Uchiyama
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