Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1997467983', 'doi': 'https://doi.org/10.1007/s00239-012-9536-x', 'title': 'Fixation and Accumulation of Thermotolerant Catalytic Competence of a Pair of Ligase Ribozymes Through Complex Formation and Cross Ligation', 'display_name': 'Fixation and Accumulation of Thermotolerant Catalytic Competence of a Pair of Ligase Ribozymes Through Complex Formation and Cross Ligation', 'publication_year': 2013, 'publication_date': '2013-01-03', 'ids': {'openalex': 'https://openalex.org/W1997467983', 'doi': 'https://doi.org/10.1007/s00239-012-9536-x', 'mag': '1997467983', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23288433'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00239-012-9536-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144184862', 'display_name': 'Journal of Molecular Evolution', 'issn_l': '0022-2844', 'issn': ['0022-2844', '1432-1432'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5039652647', 'display_name': 'Nana Isomoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Nana Isomoto', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047340614', 'display_name': 'Yuri Maeda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yuri Maeda', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100713668', 'display_name': 'Takahiro Tanaka', 'orcid': 'https://orcid.org/0000-0002-4913-2720'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takahiro Tanaka', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012231366', 'display_name': 'Hiroyuki Furuta', 'orcid': 'https://orcid.org/0000-0002-3881-8807'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroyuki Furuta', 'raw_affiliation_strings': ['Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Moto-oka 744, Nishi-ku, Fukuoka, 819-0395, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030831341', 'display_name': 'Yoshiya Ikawa', 'orcid': 'https://orcid.org/0000-0002-6814-0443'}, 'institutions': [{'id': 'https://openalex.org/I135598925', 'display_name': 'Kyushu University', 'ror': 'https://ror.org/00p4k0j84', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I135598925']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshiya Ikawa', 'raw_affiliation_strings': ['International Research Center for Molecular Systems, Kyushu University, Moto-Oka 744, Nishi-ku, Fukuoka, 819-0395, Japan'], 'affiliations': [{'raw_affiliation_string': 'International Research Center for Molecular Systems, Kyushu University, Moto-Oka 744, Nishi-ku, Fukuoka, 819-0395, Japan', 'institution_ids': ['https://openalex.org/I135598925']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2890, 'currency': 'EUR', 'value_usd': 3690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.405, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 3, 'citation_normalized_percentile': {'value': 0.528688, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 76, 'max': 78}, 'biblio': {'volume': '76', 'issue': '1-2', 'first_page': '48', 'last_page': '58'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10521', 'display_name': 'Ribosome Structure and Translation Mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11445', 'display_name': 'Origin of Life and Prebiotic Chemistry', 'score': 0.9956, 'subfield': {'id': 'https://openalex.org/subfields/3103', 'display_name': 'Astronomy and Astrophysics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10044', 'display_name': 'Protein Structure Prediction and Analysis', 'score': 0.9799, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ligase-ribozyme', 'display_name': 'Ligase ribozyme', 'score': 0.91155016}, {'id': 'https://openalex.org/keywords/rna-ligase', 'display_name': 'RNA ligase', 'score': 0.7811513}, {'id': 'https://openalex.org/keywords/rna-structure', 'display_name': 'RNA Structure', 'score': 0.532761}, {'id': 'https://openalex.org/keywords/autocatalysis', 'display_name': 'Autocatalysis', 'score': 0.502119}, {'id': 'https://openalex.org/keywords/okazaki-fragments', 'display_name': 'Okazaki fragments', 'score': 0.48176882}], 'concepts': [{'id': 'https://openalex.org/C76346623', 'wikidata': 'https://www.wikidata.org/wiki/Q205858', 'display_name': 'Ribozyme', 'level': 4, 'score': 0.95270216}, {'id': 'https://openalex.org/C1342335', 'wikidata': 'https://www.wikidata.org/wiki/Q6545871', 'display_name': 'Ligase ribozyme', 'level': 5, 'score': 0.91155016}, {'id': 'https://openalex.org/C2909068217', 'wikidata': 'https://www.wikidata.org/wiki/Q7277177', 'display_name': 'RNA ligase', 'level': 4, 'score': 0.7811513}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.6439201}, {'id': 'https://openalex.org/C175114707', 'wikidata': 'https://www.wikidata.org/wiki/Q408483', 'display_name': 'DNA ligase', 'level': 3, 'score': 0.6402744}, {'id': 'https://openalex.org/C179437574', 'wikidata': 'https://www.wikidata.org/wiki/Q15089798', 'display_name': 'Ligation', 'level': 2, 'score': 0.6214772}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6112637}, {'id': 'https://openalex.org/C11305352', 'wikidata': 'https://www.wikidata.org/wiki/Q845661', 'display_name': 'Okazaki fragments', 'level': 5, 'score': 0.48176882}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.43679753}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.41114575}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.36311167}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.35596925}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35208213}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.35207734}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.2803681}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.15983704}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0583435}, {'id': 'https://openalex.org/C98086919', 'wikidata': 'https://www.wikidata.org/wiki/Q118019', 'display_name': 'Eukaryotic DNA replication', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D011130', 'descriptor_name': 'RNA Ligase (ATP)', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009690', 'descriptor_name': 'Nucleic Acid Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009841', 'descriptor_name': 'Oligonucleotides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009841', 'descriptor_name': 'Oligonucleotides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009841', 'descriptor_name': 'Oligonucleotides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011130', 'descriptor_name': 'RNA Ligase (ATP)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011130', 'descriptor_name': 'RNA Ligase (ATP)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016337', 'descriptor_name': 'RNA, Catalytic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00239-012-9536-x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144184862', 'display_name': 'Journal of Molecular Evolution', 'issn_l': '0022-2844', 'issn': ['0022-2844', '1432-1432'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23288433', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1498432630', 'https://openalex.org/W1543796220', 'https://openalex.org/W1963738030', 'https://openalex.org/W1968282235', 'https://openalex.org/W1969860886', 'https://openalex.org/W1970877798', 'https://openalex.org/W1975677828', 'https://openalex.org/W1983885024', 'https://openalex.org/W1992304492', 'https://openalex.org/W2000712123', 'https://openalex.org/W2010790220', 'https://openalex.org/W2012621789', 'https://openalex.org/W2018374043', 'https://openalex.org/W2020403950', 'https://openalex.org/W2021333801', 'https://openalex.org/W2021492857', 'https://openalex.org/W2025901416', 'https://openalex.org/W2027324393', 'https://openalex.org/W2037104560', 'https://openalex.org/W2040539237', 'https://openalex.org/W2043738015', 'https://openalex.org/W2044449550', 'https://openalex.org/W2045464972', 'https://openalex.org/W2049446075', 'https://openalex.org/W2050110866', 'https://openalex.org/W2050869467', 'https://openalex.org/W2052429917', 'https://openalex.org/W2053143020', 'https://openalex.org/W2070117110', 'https://openalex.org/W2072872616', 'https://openalex.org/W2088659958', 'https://openalex.org/W2095667199', 'https://openalex.org/W2110879937', 'https://openalex.org/W2117819197', 'https://openalex.org/W2133292738', 'https://openalex.org/W2133830966', 'https://openalex.org/W2136118328', 'https://openalex.org/W2139966953', 'https://openalex.org/W2144384550', 'https://openalex.org/W2152987358', 'https://openalex.org/W2164701497', 'https://openalex.org/W2169628209', 'https://openalex.org/W3041019241'], 'related_works': ['https://openalex.org/W4384558004', 'https://openalex.org/W4378376141', 'https://openalex.org/W35665488', 'https://openalex.org/W2970423437', 'https://openalex.org/W2261558869', 'https://openalex.org/W2168213030', 'https://openalex.org/W2072879379', 'https://openalex.org/W2043738015', 'https://openalex.org/W2043579027', 'https://openalex.org/W1997467983'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1997467983', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-09-26T19:27:08.307151', 'created_date': '2016-06-24'}