Title: Efficient Synthesis of Hydroxyl Isoindolones by a Pd‐Mediated CH Activation/Annulation Reaction
Abstract: Chemistry – A European JournalVolume 19, Issue 34 p. 11184-11188 Communication Efficient Synthesis of Hydroxyl Isoindolones by a Pd-Mediated CH Activation/Annulation Reaction Qingzhen Yu, Qingzhen Yu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorNana Zhang, Nana Zhang Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorProf. Dr. Jianhui Huang, Corresponding Author Prof. Dr. Jianhui Huang [email protected] Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031 Synergetic Innovation Center of Chemical Science and Engineering, Tianjin (P. R. China)Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorShaonan Lu, Shaonan Lu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorYi Zhu, Yi Zhu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorXiaoxiao Yu, Xiaoxiao Yu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorProf. Dr. Kang Zhao, Corresponding Author Prof. Dr. Kang Zhao [email protected] Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this author Qingzhen Yu, Qingzhen Yu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorNana Zhang, Nana Zhang Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorProf. Dr. Jianhui Huang, Corresponding Author Prof. Dr. Jianhui Huang [email protected] Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031 Synergetic Innovation Center of Chemical Science and Engineering, Tianjin (P. R. China)Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorShaonan Lu, Shaonan Lu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorYi Zhu, Yi Zhu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorXiaoxiao Yu, Xiaoxiao Yu Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this authorProf. Dr. Kang Zhao, Corresponding Author Prof. Dr. Kang Zhao [email protected] Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin (P. R. China), Fax: (+86) 2227404031Search for more papers by this author First published: 10 July 2013 https://doi.org/10.1002/chem.201302031Citations: 64Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Radical reaction: A convenient synthesis of hydroxyl isoindolones by a Pd-catalyzed CH activation/annulation reaction with near “click chemistry” efficiency is presented (see scheme; TBHP=tert-butyl hydrogen peroxide). This methodology features short reaction times (10–30 min), high atom economy, wide substrate scope (22 examples), and good reaction yields (up to 93 %). Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description chem_201302031_sm_miscellaneous_information.pdf1.8 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume19, Issue34August 19, 2013Pages 11184-11188 RelatedInformation
Publication Year: 2013
Publication Date: 2013-07-10
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 77
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