Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1997270358', 'doi': 'https://doi.org/10.1002/path.3978', 'title': 'Central role of lactic acidosis in cancer cell resistance to glucose deprivation‐induced cell death', 'display_name': 'Central role of lactic acidosis in cancer cell resistance to glucose deprivation‐induced cell death', 'publication_year': 2012, 'publication_date': '2012-02-17', 'ids': {'openalex': 'https://openalex.org/W1997270358', 'doi': 'https://doi.org/10.1002/path.3978', 'mag': '1997270358', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22190257'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/path.3978', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4394736614', 'display_name': 'The Journal of Pathology', 'issn_l': '0022-3417', 'issn': ['0022-3417', '1096-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5082158663', 'display_name': 'Hao Wu', 'orcid': 'https://orcid.org/0000-0001-8599-3950'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Hao Wu', 'raw_affiliation_strings': ['Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I76130692']}, {'raw_affiliation_string': 'These authors contributed equally to this work.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083453012', 'display_name': 'Zonghui Ding', 'orcid': 'https://orcid.org/0000-0001-9291-6435'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zonghui Ding', 'raw_affiliation_strings': ['Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'These authors contributed equally to this work.'], 'affiliations': [{'raw_affiliation_string': 'Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I76130692']}, {'raw_affiliation_string': 'These authors contributed equally to this work.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019958677', 'display_name': 'Danqing Hu', 'orcid': 'https://orcid.org/0000-0003-0810-4819'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Danqing Hu', 'raw_affiliation_strings': ['Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004735532', 'display_name': 'Feifei Sun', 'orcid': 'https://orcid.org/0000-0001-9539-1451'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Feifei Sun', 'raw_affiliation_strings': ['Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100814839', 'display_name': 'Chunyan Dai', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunyan Dai', 'raw_affiliation_strings': ['Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101838459', 'display_name': 'Jiansheng Xie', 'orcid': 'https://orcid.org/0000-0002-9329-8939'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jiansheng Xie', 'raw_affiliation_strings': ['Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041976342', 'display_name': 'Xun Hu', 'orcid': 'https://orcid.org/0000-0002-3784-371X'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Xun Hu', 'raw_affiliation_strings': ['Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China'], 'affiliations': [{'raw_affiliation_string': 'Cancer Institute (Key Laboratory for Cancer Intervention and Prevention, China National Ministry of Education, Zhejiang Provincial Key Laboratory of Molecular Biology in Medical Sciences), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China', 'institution_ids': ['https://openalex.org/I76130692']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5041976342'], 'corresponding_institution_ids': ['https://openalex.org/I76130692'], 'apc_list': None, 'apc_paid': None, 'fwci': 2.641, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 115, 'citation_normalized_percentile': {'value': 0.99989, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '227', 'issue': '2', 'first_page': '189', 'last_page': '199'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10631', 'display_name': 'Metabolic Reprogramming in Cancer Biology', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10587', 'display_name': 'Role of Autophagy in Disease and Health', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lactic-acidosis', 'display_name': 'Lactic acidosis', 'score': 0.89274645}, {'id': 'https://openalex.org/keywords/cancer-cell-metabolism', 'display_name': 'Cancer Cell Metabolism', 'score': 0.546689}, {'id': 'https://openalex.org/keywords/tumor-microenvironment', 'display_name': 'Tumor Microenvironment', 'score': 0.525859}, {'id': 'https://openalex.org/keywords/cell-death', 'display_name': 'Cell Death', 'score': 0.525652}, {'id': 'https://openalex.org/keywords/cancer', 'display_name': 'Cancer', 'score': 0.523044}], 'concepts': [{'id': 'https://openalex.org/C2780317664', 'wikidata': 'https://www.wikidata.org/wiki/Q1500373', 'display_name': 'Lactic acidosis', 'level': 2, 'score': 0.89274645}, {'id': 'https://openalex.org/C2778553927', 'wikidata': 'https://www.wikidata.org/wiki/Q185089', 'display_name': 'Acidosis', 'level': 2, 'score': 0.79272246}, {'id': 'https://openalex.org/C2775920511', 'wikidata': 'https://www.wikidata.org/wiki/Q161249', 'display_name': 'Lactic acid', 'level': 3, 'score': 0.5509257}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.5129099}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5083739}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.47325876}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.47009063}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.43443316}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38677725}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.38164124}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.33754787}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.32806027}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.19349927}, {'id': 'https://openalex.org/C523546767', 'wikidata': 'https://www.wikidata.org/wiki/Q10876', 'display_name': 'Bacteria', 'level': 2, 'score': 0.04905373}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000140', 'descriptor_name': 'Acidosis, Lactic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D059016', 'descriptor_name': 'Tumor Microenvironment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000140', 'descriptor_name': 'Acidosis, Lactic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000140', 'descriptor_name': 'Acidosis, Lactic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D000140', 'descriptor_name': 'Acidosis, Lactic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059585', 'descriptor_name': 'G1 Phase Cell Cycle Checkpoints', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005947', 'descriptor_name': 'Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/path.3978', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4394736614', 'display_name': 'The Journal of Pathology', 'issn_l': '0022-3417', 'issn': ['0022-3417', '1096-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22190257', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.55, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 64, 'referenced_works': ['https://openalex.org/W1570230480', 'https://openalex.org/W1582456049', 'https://openalex.org/W1643149493', 'https://openalex.org/W1907876474', 'https://openalex.org/W1970430170', 'https://openalex.org/W1970554352', 'https://openalex.org/W1971985117', 'https://openalex.org/W1972220057', 'https://openalex.org/W1980235160', 'https://openalex.org/W1980254337', 'https://openalex.org/W1983749833', 'https://openalex.org/W1983889725', 'https://openalex.org/W1991429659', 'https://openalex.org/W2010749876', 'https://openalex.org/W2015207840', 'https://openalex.org/W2017728303', 'https://openalex.org/W2024334459', 'https://openalex.org/W2032717943', 'https://openalex.org/W2041687573', 'https://openalex.org/W2046177079', 'https://openalex.org/W2046687522', 'https://openalex.org/W2048729396', 'https://openalex.org/W2049283940', 'https://openalex.org/W2055255976', 'https://openalex.org/W2060592426', 'https://openalex.org/W2065472817', 'https://openalex.org/W2066379425', 'https://openalex.org/W2067692987', 'https://openalex.org/W2070224555', 'https://openalex.org/W2072451938', 'https://openalex.org/W2073771554', 'https://openalex.org/W2078893058', 'https://openalex.org/W2079941948', 'https://openalex.org/W2081066601', 'https://openalex.org/W2086997734', 'https://openalex.org/W2097259163', 'https://openalex.org/W2099348997', 'https://openalex.org/W2108623236', 'https://openalex.org/W2110025151', 'https://openalex.org/W2110075925', 'https://openalex.org/W2113572376', 'https://openalex.org/W2117692326', 'https://openalex.org/W2117812417', 'https://openalex.org/W2130503287', 'https://openalex.org/W2132354921', 'https://openalex.org/W2133000461', 'https://openalex.org/W2140880538', 'https://openalex.org/W2142013301', 'https://openalex.org/W2142765712', 'https://openalex.org/W2142859704', 'https://openalex.org/W2151410975', 'https://openalex.org/W2156687584', 'https://openalex.org/W2157795344', 'https://openalex.org/W2163471981', 'https://openalex.org/W2164300744', 'https://openalex.org/W2164547751', 'https://openalex.org/W2165836181', 'https://openalex.org/W2170989872', 'https://openalex.org/W2187537492', 'https://openalex.org/W2316875490', 'https://openalex.org/W2804842145', 'https://openalex.org/W33354229', 'https://openalex.org/W4294107304', 'https://openalex.org/W45534775'], 'related_works': ['https://openalex.org/W4236818914', 'https://openalex.org/W4211237721', 'https://openalex.org/W3168822392', 'https://openalex.org/W2986100752', 'https://openalex.org/W2412014884', 'https://openalex.org/W2379600107', 'https://openalex.org/W2312826111', 'https://openalex.org/W2052585305', 'https://openalex.org/W1997270358', 'https://openalex.org/W1993072600'], 'abstract_inverted_index': {'Abstract': [0], 'Solid': [1], 'tumours': [2], 'are': [3, 8], 'dependent': [4], 'on': [5, 210], 'glucose,': [6], 'but': [7, 223], 'generally': [9, 19], 'glucose‐deprived': [10], 'due': [11], 'to': [12, 29, 34, 59, 62, 77, 96, 202, 237, 267], 'poor': [13], 'vascularization.': [14], 'Nevertheless,': [15], 'cancer': [16, 31, 44, 57, 74, 113, 132, 183, 235, 265], 'cells': [17, 32, 58, 114, 133, 149, 159, 172, 184, 236, 266], 'can': [18, 218], 'survive': [20], 'glucose': [21, 35, 63, 78, 116, 124, 165, 169, 186, 203, 214, 239, 268], 'deprivation': [22, 117, 125], 'better': [23], 'than': [24], 'their': [25], 'normal': [26], 'counterparts.': [27], 'Thus,': [28, 231], 'render': [30], 'sensitive': [33], 'depletion': [36], 'may': [37, 55, 72, 260], 'potentially': [38], 'provide': [39], 'an': [40], 'effective': [41], 'strategy': [42], 'for': [43], 'intervention.': [45], 'We': [46], 'propose': [47], 'that': [48, 67, 255], 'lactic': [49, 70, 90, 119, 127, 144, 199, 229, 250, 258], 'acidosis,': [50, 81, 128, 145, 251], 'a': [51, 136, 140, 152], 'tumour': [52], 'microenvironment': [53], 'factor,': [54], 'allow': [56], 'develop': [60], 'resistance': [61, 201], 'deprivation‐induced': [64, 240], 'death,': [65, 101], 'and': [66, 106, 192, 252, 278], 'disruption': [68], 'of': [69, 110, 130, 147, 154, 181, 234, 264, 275], 'acidosis': [71, 84, 120, 176, 216, 259], 'resume': [73, 261], "cells'": [75], 'sensitivity': [76, 263], 'depletion.': [79], 'Lactic': [80, 175], 'lactosis,': [82], 'or': [83, 94], 'was': [85, 166], 'generated': [86], 'by': [87, 249, 281], 'adding': [88], 'pure': [89], 'acid,': [91], 'sodium': [92], 'lactate,': [93], 'HCl': [95], 'the': [97, 111, 232, 257, 262], 'culture': [98], 'medium.': [99], 'Cell': [100], 'cell': [102, 211, 220, 241], 'cycle,': [103], 'autophagy,': [104], 'apoptosis,': [105], 'gene': [107], 'expression': [108], 'profiling': [109], 'surviving': [112, 171], 'under': [115, 143, 185, 213], 'with': [118, 157, 198], 'were': [121, 195], 'determined.': [122], 'Under': [123], 'without': [126], '90%': [129, 146], '4T1': [131, 148], 'died': [134, 150], 'within': [135], 'single': [137], 'day;': [138], 'in': [139, 151, 247], 'sharp': [141], 'contrast,': [142], 'period': [153], '10': [155], 'days,': [156], 'viable': [158], 'identified': [160], 'even': [161], '65': [162], 'days': [163], 'after': [164], 'depleted.': [167], 'Upon': [168], 'restoration,': [170], 'resumed': [173], 'proliferation.': [174], 'also': [177], 'significantly': [178], 'extended': [179], 'survival': [180, 212, 221], 'other': [182], 'deprivation.': [187, 204, 269], 'G1/G0': [188], 'arrest,': [189], 'autophagy': [190], 'induction,': [191], 'apoptosis': [193], 'inhibition': [194], 'tightly': [196], 'associated': [197], 'acidosis‐mediated': [200], 'Lactosis': [205], 'alone': [206, 217], 'had': [207], 'no': [208], 'effect': [209], 'deprivation;': [215], 'prolong': [219], 'time': [222], 'is': [224, 243], 'not': [225], 'as': [226, 228], 'potent': [227], 'acidosis.': [230], 'ability': [233], 'resist': [238], 'death': [242], 'conferred,': [244], 'at': [245], 'least': [246], 'part,': [248], 'we': [253], 'envision': [254], 'disrupting': [256], 'Copyright': [270], '©': [271], '2012': [272], 'Pathological': [273], 'Society': [274], 'Great': [276], 'Britain': [277], 'Ireland.': [279], 'Published': [280], 'John': [282], 'Wiley': [283], '&': [284], 'Sons,': [285], 'Ltd.': [286]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1997270358', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 18}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-11T19:58:58.269809', 'created_date': '2016-06-24'}