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[43], 'effectors': [46], 'in': [47, 51, 103, 109, 119, 133, 158, 178, 189, 211], 'Bordetella,': [48], 'secreted': [49, 86, 93], 'proteins': [50], 'bacterial': [53], 'culture': [54], 'supernatants': [55], 'wild-type': [57], 'an': [61, 129], 'isogenic': [62], 'T3SS-deficient': [63], 'mutant': [64, 101], 'were': [65, 155], 'compared': [66], 'iTRAQ-based,': [68], 'quantitative': [69], 'proteomic': [70], 'analysis': [71], 'method.': [72], 'BB1639,': [73], 'annotated': [74], 'as': [75, 81, 208], 'hypothetical': [77], 'protein,': [78], 'was': [79, 89, 106, 115, 175], 'identified': [80], 'novel': [83], 'protein': [87, 94], 'designated': [90], 'BspR': [91, 100, 114, 127, 186], '(Bordetella': [92], 'regulator).': [95], 'The': [96], '(ΔbspR)': [102], 'significantly': [107], 'attenuated': [108], 'mouse': [111], 'infection': [112], 'model.': [113], 'also': [116, 156], 'highly': [117], 'conserved': [118], 'suggesting': [125], 'essential': [130], 'factor': [132], 'these': [134], 'three': [135], 'species.': [137], 'Interestingly,': [138], 'BspR-deficient': [140, 180], 'strain': [141], 'showed': [142], 'hyper-secretion': [143], 'T3SS-related': [145], 'Furthermore,': [147], 'T3SS-dependent': [148], 'host': [149], 'cell': [150], 'cytotoxicity': [151], 'hemolytic': [153], 'activity': [154], 'enhanced': [157], 'absence': [160], 'BspR.': [162], 'By': [163], 'contrast,': [164], 'expression': [166], 'filamentous': [168], 'hemagglutinin,': [169], 'pertactin,': [170], 'adenylate': [172], 'cyclase': [173], 'toxin': [174], 'completely': [176], 'abolished': [177], 'strain.': [181], 'Finally,': [182], 'we': [183], 'demonstrated': [184], 'involved': [188], 'iron-responsive': [191], 'regulation': [192], 'T3SS.': [194], 'Thus,': [195], 'factors': [198], 'are': [199], 'coordinately': [200], 'but': [201], 'inversely': [202], 'controlled': [203], 'by': [204], 'BspR,': [205], 'which': [206], 'functions': [207], 'regulator': [210], 'response': [212], 'to': [213], 'iron': [214], 'starvation.': 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