Publication Information

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'https://openalex.org/W2605340400', 'https://openalex.org/W2163047733', 'https://openalex.org/W1985194733', 'https://openalex.org/W1965627131'], 'abstract_inverted_index': {'Sirt3': [0, 41, 72, 114, 131, 147, 161, 188, 229, 260, 302, 319, 335, 349, 860, 910, 1027, 1257, 1282, 1335, 1512, 1522, 1555, 1561, 1594, 1721, 1830, 1906, 1948, 2106, 2137, 2219, 2250, 2425, 2469, 2521, 3032, 3082, 3199, 3429, 3454, 3507], '(silent': [1, 189], 'mating': [2, 190, 498, 2670], 'type': [3, 191, 405, 499, 513, 2577, 2671, 2685], 'information': [4, 192, 500, 2672], 'regulation': [5, 193, 501, 1354, 1514, 2673], '2,': [6, 194, 502, 2674], 'homolog': [7, 195, 503, 2675], '3),': [8, 196], 'a': [9, 88, 183, 197, 276, 371, 380, 402, 569, 609, 614, 735, 788, 1327, 1395, 1401, 1427, 1564, 1653, 1822, 2530, 2552, 2574, 2741, 2781, 2786, 2907, 2960, 3499], 'member': [10, 198], 'of': [11, 15, 48, 54, 57, 83, 87, 93, 107, 119, 146, 171, 182, 199, 203, 236, 242, 245, 271, 275, 281, 295, 307, 334, 359, 370, 386, 398, 426, 432, 469, 473, 476, 537, 541, 558, 563, 620, 655, 684, 690, 695, 746, 778, 787, 798, 840, 1265, 1269, 1288, 1330, 1333, 1345, 1349, 1355, 1367, 1385, 1409, 1511, 1547, 1560, 1571, 1584, 1598, 1613, 1656, 1720, 1825, 1829, 1918, 1928, 1931, 1954, 1981, 2063, 2104, 2114, 2136, 2156, 2232, 2248, 2258, 2271, 2293, 2337, 2341, 2373, 2424, 2433, 2475, 2520, 2544, 2558, 2570, 2598, 2604, 2641, 2645, 2648, 2709, 2713, 2730, 2735, 2792, 2827, 2856, 2862, 2867, 2918, 2950, 2959, 2970, 3012, 3437, 3441, 3460, 3502, 3505, 3517, 3521], 'the': [12, 55, 105, 120, 129, 172, 179, 200, 243, 293, 308, 317, 360, 367, 384, 424, 430, 443, 474, 477, 538, 559, 618, 621, 651, 688, 696, 776, 785, 819, 1286, 1319, 1331, 1334, 1343, 1346, 1350, 1365, 1381, 1386, 1406, 1470, 1508, 1544, 1558, 1569, 1575, 1582, 1596, 1611, 1657, 1682, 1693, 1826, 1915, 1922, 1926, 1955, 1979, 2043, 2058, 2064, 2105, 2111, 2124, 2134, 2218, 2225, 2235, 2246, 2249, 2255, 2268, 2276, 2291, 2334, 2349, 2374, 2386, 2422, 2431, 2473, 2481, 2518, 2542, 2556, 2596, 2602, 2615, 2646, 2649, 2710, 2731, 2790, 2793, 2823, 2860, 2868, 2948, 2957, 2991, 3458, 3491, 3503, 3506, 3515, 3518, 3522], 'sirtuin': [13, 201, 1658], 'family': [14, 202], 'protein': [16, 204, 459, 489, 822, 1654, 1912, 2272, 2631, 2661, 2994], 'deacetylases': [17, 205, 823, 2995], 'with': [18, 30, 206, 218, 650, 1158, 1250, 1610, 1621, 2254, 2379, 2822, 3330, 3422], 'multiple': [19, 207, 2209], 'actions': [20, 208], 'on': [21, 209, 826, 1978, 2267, 2385, 2998], 'metabolism': [22, 210, 1674], 'and': [23, 78, 164, 211, 266, 352, 449, 457, 529, 535, 630, 633, 644, 804, 830, 865, 978, 1092, 1276, 1525, 1660, 1675, 1960, 2212, 2242, 2345, 2525, 2621, 2629, 2701, 2707, 2802, 2805, 2816, 2976, 3002, 3037, 3150, 3264, 3448], 'gene': [24, 73, 94, 115, 132, 148, 162, 212, 261, 282, 303, 320, 336, 350, 478, 700, 780, 1154, 1258, 1290, 1356, 1410, 1513, 1523, 1549, 1676, 1725, 1932, 2066, 2107, 2251, 2388, 2426, 2470, 2650, 2872, 2952, 3326, 3430, 3462], 'expression': [25, 56, 74, 106, 149, 163, 213, 244, 262, 294, 337, 351, 475, 694, 781, 803, 1253, 1259, 1291, 1357, 1411, 1524, 1550, 1624, 1726, 1933, 1949, 2062, 2427, 2471, 2519, 2647, 2866, 2953, 2975, 3425, 3431, 3463], 'is': [26, 42, 141, 167, 214, 230, 329, 355, 396, 568, 606, 608, 806, 861, 1241, 1260, 1283, 1326, 1358, 1394, 1463, 1528, 1540, 1606, 1652, 1661, 1679, 1686, 1800, 1804, 1950, 1961, 2067, 2143, 2252, 2331, 2371, 2419, 2568, 2740, 2778, 2780, 2978, 3033, 3413, 3432, 3455, 3498], 'expressed': [27, 215, 1243, 2274, 3415], 'in': [28, 75, 150, 216, 263, 338, 383, 389, 411, 423, 429, 442, 533, 585, 617, 638, 792, 818, 863, 867, 919, 1244, 1248, 1254, 1262, 1285, 1292, 1388, 1404, 1515, 1551, 1595, 1607, 1619, 1673, 1730, 1831, 1925, 1984, 2051, 2070, 2108, 2117, 2158, 2244, 2260, 2275, 2472, 2490, 2495, 2499, 2522, 2541, 2555, 2561, 2583, 2595, 2601, 2614, 2705, 2757, 2789, 2810, 2964, 2990, 3035, 3039, 3091, 3416, 3420, 3426, 3434, 3457, 3464], 'association': [29, 217], 'brown': [31, 36, 58, 89, 108, 184, 219, 224, 246, 277, 296, 372, 399, 564, 582, 600, 623, 656, 691, 697, 737, 789, 815, 1245, 1263, 1293, 1351, 1371, 1377, 1415, 1428, 1466, 1516, 1531, 1588, 1604, 1735, 1957, 1965, 2071, 2165, 2261, 2342, 2365, 2491, 2523, 2545, 2571, 2736, 2754, 2772, 2795, 2828, 2863, 2869, 2909, 2961, 2987, 3417, 3435, 3465, 3523], 'adipocyte': [32, 185, 220, 373, 565, 583, 601, 624, 738, 790, 816, 1416, 1532, 1958, 2262, 2546, 2737, 2755, 2773, 2796, 2910, 2962, 2988], 'differentiation.': [33, 221, 1417, 1534], 'Using': [34, 222], 'Sirt3-null': [35, 223, 1982], 'adipocytes,': [37, 225, 692, 1517, 2524, 2864], 'we': [38, 226, 1322, 2055, 2513, 3494], 'determined': [39, 227], 'that': [40, 139, 158, 228, 327, 346, 395, 612, 800, 824, 1152, 1281, 1324, 1412, 1519, 1538, 1553, 1557, 1566, 1579, 1905, 1947, 2042, 2057, 2126, 2377, 2417, 2466, 2480, 2515, 2567, 2784, 2972, 2996, 3324, 3453, 3496], 'required': [43, 142, 231, 330, 1359, 1464, 1963], 'for': [44, 143, 232, 331, 479, 810, 1026, 1465, 1530, 1593, 1964, 2133, 2283, 2333, 2347, 2352, 2364, 2368, 2421, 2505, 2651, 2982, 3198], 'an': [45, 168, 233, 356, 793, 807, 1951, 2965, 2979], 'appropriate': [46, 234], 'responsiveness': [47, 235], 'cells': [49, 97, 237, 285, 1362, 1552, 1620], 'to': [50, 102, 152, 238, 290, 340, 407, 413, 437, 454, 467, 587, 598, 680, 743, 813, 1342, 1360, 1363, 1379, 1390, 1399, 1414, 1425, 1468, 1472, 1542, 1568, 1573, 1581, 1600, 1616, 1663, 1681, 1692, 1722, 1806, 1810, 1938, 1967, 1969, 2045, 2100, 2163, 2222, 2280, 2285, 2297, 2303, 2381, 2579, 2585, 2609, 2626, 2639, 2759, 2770, 2852, 2915, 2985, 3514], 'noradrenergic,': [51, 239], 'cAMP-mediated': [52, 240, 1289, 3461], 'activation': [53, 241, 468, 536, 745, 1475, 1602, 1618, 2155, 2640, 2708, 2917], 'adipose': [59, 90, 247, 278, 377, 657, 794, 1246, 1352, 2166, 2343, 2549, 2829, 2966, 3418, 3524], 'tissue': [60, 248, 378, 658, 2167, 2550, 2830], 'thermogenic': [61, 110, 249, 298, 566, 653, 1271, 1347, 1383, 1474, 1548, 1586, 1601, 1971, 2168, 2738, 2825, 3443, 3519], 'genes.': [62, 111, 250, 299], 'The': [63, 154, 251, 342, 391, 796, 1535, 1590, 1718, 2230, 2413, 2563, 2968], 'transcriptional': [64, 252, 610, 831, 1396, 2269, 2782, 3003], 'coactivator': [65, 253, 611, 1397, 2783], 'Pgc-1α': [66, 100, 112, 159, 177, 254, 288, 300, 347, 365, 626, 733, 779, 802, 1393, 1419, 1462, 1520, 1539, 1572, 1623, 2205, 2380, 2383, 2467, 2516, 2536, 2798, 2905, 2951, 2974], '(peroxisome': [67, 255], 'proliferator-activated': [68, 256, 493, 2665], 'receptor-γ': [69, 257, 494, 2666], 'coactivator-1α)': [70, 258], 'induced': [71, 259], 'white': [76, 264, 419, 578, 676, 1255, 1423, 2591, 2750, 2848, 3427], 'adipocytes': [77, 265, 400, 420, 435, 579, 677, 1378, 1424, 1467, 1605, 1736, 1966, 2492, 2572, 2592, 2607, 2751, 2849], 'embryonic': [79, 267, 523, 2695], 'fibroblasts': [80, 268], 'as': [81, 269, 869, 924, 1274, 1695, 1833, 2234, 2264, 2266, 2288, 3041, 3096, 3446], 'part': [82, 270], 'its': [84, 272, 1251, 2215, 2538, 3423], 'overall': [85, 173, 273, 361, 2112], 'induction': [86, 145, 274, 333, 472, 1408, 1559, 1930, 2247, 2543, 2644], 'tissue-specific': [91, 279], 'pattern': [92, 280], 'expression.': [95, 283, 1677], 'In': [96, 284, 417, 573, 908, 1940, 2511, 2589, 2745, 3080], 'lacking': [98, 286, 732, 2295, 2904], 'Sirt3,': [99, 287, 496, 2668], 'failed': [101, 289], 'fully': [103, 291, 1585], 'induce': [104, 292], 'fat-specific': [109, 297, 698, 2870], 'activates': [113, 301, 635, 2807], 'transcription': [116, 304, 631, 828, 1332, 2213, 2236, 2375, 2803, 3000, 3504], 'through': [117, 305, 440, 451, 2612, 2623], 'coactivation': [118, 306], 'orphan': [121, 309, 2226], 'nuclear': [122, 310, 506, 628, 1724, 2210, 2227, 2678, 2800], 'receptor': [123, 311, 2228], 'Err': [124, 312], '(estrogen-related': [125, 313], 'receptor)-α,': [126, 314], 'which': [127, 176, 315, 364, 446, 647, 1506, 2500, 2535, 2618, 2819], 'bound': [128, 316], 'proximal': [130, 318], 'promoter': [133, 321, 2220], 'region.': [134, 322], 'Errα': [135, 140, 323, 328, 2233, 2259, 2278, 2296, 2330, 2354, 2418], 'knockdown': [136, 324], 'assays': [137, 325], 'indicated': [138, 326, 1151, 3323], 'full': [144, 180, 332, 368, 1533, 1545], 'response': [151, 339, 412, 586, 1389, 2044, 2584, 2758], 'Pgc-1α.': [153, 341, 2429], 'present': [155, 343, 862, 1320, 1504, 1944, 2414, 3034, 3492], 'results': [156, 344], 'indicate': [157, 345, 1518, 1946], 'controls': [160, 348, 911, 2468, 2517, 3083], 'this': [165, 353, 463, 1338, 1526, 1803, 2356, 2434, 2526, 2635, 3510], 'action': [166, 354, 2216, 2384], 'essential': [169, 357, 1529, 1952, 2282, 2420], 'component': [170, 358, 1953], 'mechanisms': [174, 362, 2533], 'by': [175, 363, 836, 915, 1603, 1668, 1835, 1908, 2240, 2290, 2358, 2428, 2534, 3008, 3087], 'induces': [178, 366, 1521], 'acquisition': [181, 369, 619, 786, 1344, 1597, 2791, 2958, 3516], 'differentiated': [186, 374], 'phenotype.': [187, 375, 625, 2547, 2797], 'IntroductionBrown': [376, 2548], 'plays': [379, 613, 2551, 2785], 'major': [381, 615, 1328, 2553, 2787, 3500], 'role': [382, 616, 1403, 2257, 2357, 2540, 2554, 2788], 'control': [385, 777, 801, 1287, 1664, 2270, 2557, 2949, 2973, 3459], 'energy': [387, 409, 428, 2350, 2559, 2581, 2600], 'expenditure': [388, 410, 2560, 2582], 'mammals.': [390, 2562], 'specific': [392, 622, 652, 1591, 1690, 1916, 1956, 2564, 2794, 2824], 'mitochondrial': [393, 645, 1809, 1814, 2501, 2565, 2817], 'uncoupling': [394, 480, 488, 540, 2566, 2652, 2660, 2712], 'characteristic': [397, 2340, 2569], 'creates': [401, 2573], 'specialized': [403, 422, 1382, 2575, 2594], 'cell': [404, 444, 1387, 1732, 2497, 2576, 2616], 'adapted': [406, 2578], 'promoting': [408, 2580], 'cold': [414, 2047, 2286, 2304, 2586], 'or': [415, 576, 589, 1817, 2151, 2587, 2748, 2761], 'overfeeding.': [416, 2588], 'contrast,': [418, 2590], 'are': [421, 648, 678, 821, 1156, 2503, 2593, 2820, 2850, 2993, 3328], 'accumulation': [425, 2597], 'metabolic': [427, 2599], 'form': [431, 2603], 'lipids.': [433, 2605], 'Brown': [434, 2606], 'respond': [436, 1968, 2608], 'noradrenergic': [438, 744, 1391, 1617, 1929, 2610, 2916], 'stimulation': [439, 2611], 'β-adrenoreceptors': [441, 2613], 'surface,': [445, 2617], 'bind': [447, 2619], 'norepinephrine': [448, 2620], 'signal': [450, 2622], 'adenylate': [452, 2624], 'cyclase': [453, 2625], 'increase': [455, 2627], 'cAMP': [456, 2152, 2628], 'activate': [458, 1543, 2630], 'kinase': [460, 2632], 'A.': [461, 895, 1050, 1078, 1118, 1841, 1863, 2008, 2079, 2081, 2177, 2316, 2396, 2633, 3067, 3222, 3250, 3290], 'Ultimately,': [462, 2634], 'signaling': [464, 1807, 2636], 'cascade': [465, 1927, 2637], 'lead': [466, 1580, 2638], 'hormone-sensitive': [470, 2642], 'lipase,': [471, 2643], 'protein-1': [481, 2653], '(Ucp1)': [482, 2654], '2The': [483, 2655], 'abbreviations': [484, 2656], 'used': [485, 2657], 'are:': [486, 2658], 'Ucp1,': [487, 2659], '1;': [490, 2662], 'Pgc-1α,': [491, 685, 2241, 2663, 2857], 'peroxisome': [492, 2664], 'coactivator-1α;': [495, 2667], 'silent': [497, 2669], '3;': [504, 2676], 'Nrf,': [505, 2677], 'respiratory': [507, 2679], 'factor;': [508, 2680], 'ERR,': [509, 2681], 'estrogen-related': [510, 2682], 'receptor;': [511, 2683], 'Dio2,': [512, 2684], 'II': [514, 2686], '5′-deiodinase;': [515, 2687], 'Fabp4,': [516, 2688], 'fatty': [517, 526, 912, 920, 2689, 2698, 3084, 3092], 'acid': [518, 913, 921, 2690, 3085, 3093], 'binding': [519, 2691], 'protein-4;': [520, 2692], 'MEF,': [521, 2693], 'mouse': [522, 2694], 'fibroblast;': [524, 2696], 'FABP,': [525, 2697], 'acid-binding': [527, 2699], 'protein.': [528, 2700], 'other': [530, 2127, 2496, 2508, 2702], 'genes': [531, 636, 2362, 2703, 2808], 'involved': [532, 637, 918, 1284, 1672, 1924, 2243, 2704, 2809, 3090, 3456], 'thermogenesis,': [534, 2706], 'Ucp1-dependent': [539, 2711], 'mitochondria': [542, 864, 1683, 2714, 3036], '(1Cannon': [543, 2715], 'B.': [544, 937, 982, 2029, 2398, 2716, 3109, 3154], 'Nedergaard': [545, 2717], 'J.': [546, 715, 753, 755, 843, 984, 1053, 1081, 1114, 1303, 1445, 1481, 1483, 1630, 1632, 1745, 1780, 1788, 1866, 1888, 1996, 2002, 2088, 2189, 2718, 2887, 2925, 2927, 3015, 3156, 3225, 3253, 3286, 3475], 'Physiol.': [547, 2089, 2719], 'Rev.': [548, 664, 2720, 2836], '2004;': [549, 2721], '84:': [550, 2722], '277-359Crossref': [551, 2723], 'PubMed': [552, 668, 726, 770, 853, 887, 903, 973, 999, 1018, 1064, 1087, 1143, 1199, 1236, 1314, 1456, 1498, 1647, 1713, 1756, 1794, 1849, 1872, 1899, 2036, 2200, 2325, 2408, 2460, 2724, 2840, 2898, 2942, 3025, 3059, 3075, 3145, 3171, 3190, 3236, 3259, 3315, 3371, 3408, 3486], 'Scopus': [553, 669, 727, 771, 854, 888, 904, 974, 1000, 1019, 1065, 1088, 1144, 1200, 1237, 1315, 1457, 1499, 1648, 1714, 1757, 1795, 1850, 1873, 1900, 2037, 2201, 2326, 2409, 2461, 2725, 2841, 2899, 2943, 3026, 3060, 3076, 3146, 3172, 3191, 3237, 3260, 3316, 3372, 3409, 3487], '(4423)': [554, 2726], 'Google': [555, 671, 729, 773, 856, 890, 906, 976, 1002, 1021, 1067, 1090, 1146, 1202, 1239, 1317, 1459, 1501, 1650, 1716, 1759, 1797, 1852, 1875, 1902, 2039, 2203, 2328, 2411, 2463, 2727, 2843, 2901, 2945, 3028, 3062, 3078, 3148, 3174, 3193, 3239, 3262, 3318, 3374, 3411, 3489], 'Scholar).': [556, 672, 730, 774, 857, 907, 1022, 1147, 1460, 1502, 1717, 1798, 1876, 2094, 2329, 2412, 2728, 2844, 2902, 2946, 3029, 3079, 3194, 3319], 'Acquisition': [557, 2729], 'cellular': [560, 1577, 2732], 'machinery': [561, 2733], 'typical': [562, 2734], 'function': [567, 654, 1384, 2263, 2739, 2826], 'highly': [570, 1242, 2742, 3414], 'plastic': [571, 2743], 'process.': [572, 2744], 'fact,': [574, 2746], 'pre-adipocytes': [575, 2747], 'even': [577, 2749], 'may': [580, 1562, 2485, 2528, 2752], 'acquire': [581, 687, 734, 1364, 1426, 1469, 2753, 2859, 2906], 'properties': [584, 2756], 'developmental': [588, 2760], 'environment': [590, 2762], 'regulators.': [591, 2763], 'Several': [592, 1148, 2764, 3320], 'molecular': [593, 2765], 'agents': [594, 2766], 'have': [595, 1150, 1934, 1975, 2767, 3322], 'been': [596, 1279, 1728, 1936, 1976, 2161, 2768, 3451], 'reported': [597, 1025, 1729, 1904, 2041, 2162, 2465, 2769, 3197], 'promote': [599, 1574, 2164, 2771], 'differentiation,': [602, 2774], 'central': [603, 2775], 'among': [604, 1921, 2776], 'them': [605, 2777], 'Pgc-1α.Pgc-1α': [607, 2779], 'coactivates': [627, 2799], 'receptors': [629, 2211, 2801], 'factors': [632, 799, 2376, 2804, 2971], 'thereby': [634, 2806], 'thermogenesis': [639, 747, 2116, 2811, 2919], '(e.g.': [640, 2129, 2812], 'Ucp1),': [641, 2813], 'lipid': [642, 2814], 'oxidation,': [643, 646, 922, 2815, 2818, 3094], 'associated': [649, 1157, 2821, 3329], '(2Handschin': [659, 2831], 'C.': [660, 702, 706, 943, 1180, 1184, 1226, 1432, 1436, 2175, 2185, 2832, 2874, 2878, 3115, 3352, 3356, 3398], 'Spiegelman': [661, 758, 1486, 1635, 2833, 2930], 'B.M.': [662, 759, 1487, 1636, 2834, 2931], 'Endocr.': [663, 2835], '2006;': [665, 762, 996, 1015, 1490, 1639, 2837, 2934, 3168, 3187], '27:': [666, 2034, 2838], '728-735Crossref': [667, 2839], '(865)': [670, 2842], 'For': [673, 2845], 'instance,': [674, 2369, 2846], 'when': [675, 2301, 2847], 'forced': [679, 2851], 'express': [681, 2853], 'high': [682, 2335, 2854], 'levels': [683, 1420, 2336, 2855], 'they': [686, 2858], 'features': [689, 2861], 'including': [693, 1734, 2865], 'Ucp1': [699, 2065, 2387, 2871], '(3Tiraby': [701, 1431, 2873], 'Tavernier': [703, 1433, 2875], 'G.': [704, 1038, 1074, 1162, 1174, 1193, 1207, 1211, 1228, 1231, 1434, 1859, 2004, 2876, 3210, 3246, 3334, 3346, 3365, 3379, 3383, 3400, 3403], 'Lefort': [705, 1435, 2877], 'Larrouy': [707, 1437, 2879], 'D.': [708, 712, 714, 897, 1132, 1168, 1205, 1438, 1442, 1444, 1786, 1843, 2006, 2390, 2394, 2880, 2884, 2886, 3069, 3304, 3340, 3377], 'Bouillaud': [709, 1439, 2881], 'F.': [710, 1216, 1298, 1440, 1740, 1883, 2077, 2452, 2882, 3388, 3470], 'Ricquier': [711, 1441, 2883], 'Langin': [713, 1443, 2885], 'Biol.': [716, 1054, 1304, 1446, 1746, 1789, 1889, 2032, 2888, 3226, 3476], 'Chem.': [717, 1055, 1305, 1447, 1747, 1890, 2889, 3227, 3477], '2003;': [718, 1196, 1448, 2890, 3368], '278:': [719, 1449, 2891], '33370-33376Abstract': [720, 1450, 2892], 'Full': [721, 723, 765, 767, 1059, 1061, 1138, 1140, 1309, 1311, 1451, 1453, 1493, 1495, 1642, 1644, 1751, 1753, 1894, 1896, 2195, 2197, 2893, 2895, 2937, 2939, 3231, 3233, 3310, 3312, 3481, 3483], 'Text': [722, 724, 766, 768, 1060, 1062, 1139, 1141, 1310, 1312, 1452, 1454, 1494, 1496, 1643, 1645, 1752, 1754, 1895, 1897, 2196, 2198, 2894, 2896, 2938, 2940, 3232, 3234, 3311, 3313, 3482, 3484], 'PDF': [725, 769, 1063, 1142, 1313, 1455, 1497, 1646, 1755, 1898, 2199, 2897, 2941, 3235, 3314, 3485], '(373)': [728, 1458, 2900], 'Cells': [731, 2903], 'partial': [736, 2908], 'phenotype': [739, 791, 1366, 1430, 2911, 2963], 'but': [740, 1914, 2493, 2912], 'remain': [741, 2913], 'insensitive': [742, 2914], '(4Uldry': [748, 1476, 1625, 2920], 'M.': [749, 1040, 1072, 1182, 1220, 1477, 1626, 1772, 1857, 2018, 2087, 2173, 2392, 2400, 2921, 3212, 3244, 3354, 3392], 'Yang': [750, 1478, 1627, 2009, 2922], 'W.': [751, 1479, 1628, 2923], 'St-Pierre': [752, 1480, 1629, 2924], 'Lin': [754, 1482, 1631, 2926], 'Seale': [756, 1484, 1633, 2928], 'P.': [757, 1112, 1209, 1485, 1634, 1776, 2929, 3284, 3381], 'Cell': [760, 846, 1488, 1637, 2190, 2932, 3018], 'Metab.': [761, 1489, 1638, 2191, 2933], '3:': [763, 1491, 1640, 2935], '333-341Abstract': [764, 1492, 1641, 2936], '(476)': [772, 1500, 1649, 2944], 'Thus,': [775, 2947], 'can': [782, 1421, 2206, 2954], 'ultimately': [783, 2955], 'determine': [784, 2101, 2956], 'cell.': [795, 2967, 3525], 'identification': [797, 2231, 2969], 'activity': [805, 817, 1272, 2169, 2977, 2989, 3444], 'important': [808, 2363, 2487, 2980], 'prerequisite': [809, 2981], 'developing': [811, 2983], 'tools': [812, 2984], 'modulate': [814, 2986], 'organisms.Sirtuins': [820, 2992], 'act': [825, 2997], 'histones,': [827, 2999], 'factors,': [829, 2214, 3001], 'co-regulators,': [832, 3004], 'modulating': [833, 3005], 'their': [834, 838, 3006, 3010], 'activities': [835, 3007], 'regulating': [837, 3009], 'degree': [839, 3011], 'acetylation': [841, 3013], '(5Bao': [842, 3014], 'Sack': [844, 3016], 'M.N.': [845, 3017], 'Mol.': [847, 2030, 2403, 3019], 'Life': [848, 3020], 'Sci.': [849, 994, 1013, 1790, 2090, 2320, 3021, 3166, 3185], '2010;': [850, 884, 970, 1056, 1135, 1710, 2457, 3022, 3056, 3142, 3228, 3307], '67:': [851, 3023], '3073-3087Crossref': [852, 3024], '(49)': [855, 3027], 'Among': [858, 3030], 'them,': [859, 3031], 'possibly': [866, 3038], 'nuclei': [868, 1811, 3040], 'well': [870, 1696, 2265, 3042], '(6Huang': [871, 1697, 3043], 'J.Y.': [872, 1698, 3044], 'Hirschey': [873, 1699, 2013, 3045], 'M.D.': [874, 929, 1700, 2014, 3046, 3101], 'Shimazu': [875, 930, 1701, 3047, 3102], 'T.': [876, 931, 1296, 1702, 1738, 1881, 3048, 3103, 3468], 'Ho': [877, 1703, 3049], 'L.': [878, 1704, 1774, 3050], 'Verdin': [879, 967, 985, 989, 1705, 2026, 3051, 3139, 3157, 3161], 'E.': [880, 933, 935, 968, 990, 1176, 1222, 1300, 1706, 1742, 1885, 2027, 2083, 3052, 3105, 3107, 3140, 3162, 3348, 3394, 3472], 'Biochim.': [881, 1707, 3053], 'Biophys.': [882, 1708, 3054], 'Acta.': [883, 1709, 3055], '1804:': [885, 1711, 3057], '1645-1651Crossref': [886, 1712, 3058], '(183)': [889, 1715, 3061], 'Scholar,': [891, 1003, 1068, 1203, 1760, 1853, 3063, 3175, 3240, 3375], '7Scher': [892, 3064], 'M.B.': [893, 1839, 2308, 3065], 'Vaquero': [894, 1840, 3066], 'Reinberg': [896, 1842, 3068], 'Genes': [898, 1844, 3070], 'Dev.': [899, 1845, 3071], '2007;': [900, 1846, 2033, 2322, 2405, 3072], '21:': [901, 1847, 2406, 3073], '920-928Crossref': [902, 1848, 3074], '(354)': [905, 1851, 3077], 'mitochondria,': [909, 3081], 'oxidation': [914, 3086], 'deacetylating': [916, 3088], 'enzymes': [917, 3089], 'such': [923, 1273, 3095, 3445], 'long-chain': [925, 3097], 'acyl-CoA': [926, 3098], 'dehydrogenase': [927, 3099], '(8Hirschey': [928, 3100], 'Goetzman': [932, 3104], 'Jing': [934, 3106], 'Schwer': [936, 2028, 3108], 'Lombard': [938, 1986, 3110], 'D.B.': [939, 1990, 3111], 'Grueter': [940, 3112], 'C.A.': [941, 3113], 'Harris': [942, 3114], 'Biddinger': [944, 3116], 'S.': [945, 1007, 1046, 1164, 1170, 1188, 1213, 2025, 3117, 3179, 3218, 3336, 3342, 3360, 3385], 'Ilkayeva': [946, 3118], 'O.R.': [947, 3119], 'Stevens': [948, 3120], 'R.D.': [949, 3121], 'Li': [950, 3122], 'Y.': [951, 2010, 2012, 2444, 2450, 2454, 3123], 'Saha': [952, 3124], 'A.K.': [953, 3125], 'Ruderman': [954, 3126], 'N.B.': [955, 3127], 'Bain': [956, 3128], 'J.R.': [957, 3129], 'Newgard': [958, 3130], 'C.B.': [959, 3131], 'Farese': [960, 2021, 3132], 'Jr.,': [961, 2022, 3133], 'R.V.': [962, 2023, 3134], 'Alt': [963, 1991, 3135], 'F.W.': [964, 1992, 3136], 'Kahn': [965, 3137], 'C.R.': [966, 3138], 'Nature.': [969, 3141], '464:': [971, 3143], '121-125Crossref': [972, 3144], '(1168)': [975, 3147], 'Scholar)': [977, 1091, 1903, 2040, 2464, 3149, 3263], 'acetyl-CoA': [979, 3151], 'synthase': [980, 3152], '(9Schwer': [981, 3153], 'Bunkenborg': [983, 1995, 3155], 'R.O.': [986, 3158], 'Andersen': [987, 3159], 'J.S.': [988, 3160], 'Proc.': [991, 1010, 2317, 3163, 3182], 'Natl.': [992, 1011, 2318, 3164, 3183], 'Acad.': [993, 1012, 2319, 3165, 3184], 'U.S.A.': [995, 1014, 2321, 3167, 3186], '103:': [997, 1016, 3169, 3188], '10224-10229Crossref': [998, 3170], '(558)': [1001, 3173], '10Hallows': [1004, 3176], 'W.C.': [1005, 3177], 'Lee': [1006, 3178], 'Denu': [1008, 3180], 'J.M.': [1009, 3181], '10230-10235Crossref': [1017, 3189], '(639)': [1020, 3192], 'Other': [1023, 3195], 'roles': [1024, 3196], 'include': [1028, 3200], 'protection': [1029, 3201], 'against': [1030, 3202], 'cardiac': [1031, 3203], 'hypertrophy': [1032, 3204], '(11Pillai': [1033, 3205], 'V.B.': [1034, 3206], 'Sundaresan': [1035, 3207], 'N.R.': [1036, 1070, 1855, 3208, 3242], 'Kim': [1037, 1073, 1769, 1858, 2001, 3209, 3245], 'Gupta': [1039, 1051, 1071, 1079, 1856, 1864, 3211, 3223, 3243, 3251], 'Rajamohan': [1041, 1075, 1860, 3213, 3247], 'S.B.': [1042, 1076, 1861, 3214, 3248], 'Pillai': [1043, 3215], 'J.B.': [1044, 3216], 'Samant': [1045, 3217], 'Ravindra': [1047, 3219], 'P.V.': [1048, 3220], 'Isbatan': [1049, 1077, 1862, 3221, 3249], 'M.P.': [1052, 1080, 1865, 3224, 3252], '285:': [1057, 3229], '3133-3144Abstract': [1058, 3230], '(315)': [1066, 3238], '12Sundaresan': [1069, 1854, 3241], 'Clin.': [1082, 1867, 3254], 'Invest.': [1083, 1868, 3255], '2009;': [1084, 1869, 2091, 3256], '119:': [1085, 1870, 3257], '2758-2771Crossref': [1086, 1871, 3258], '(781)': [1089, 1874, 3261], 'tumor': [1093, 3265], 'suppression': [1094, 3266], '(13Kim': [1095, 3267], 'H.S.': [1096, 1770, 3268], 'Patel': [1097, 3269], 'K.': [1098, 1100, 1166, 3270, 3272, 3338], 'Muldoon-Jacobs': [1099, 3271], 'Bisht': [1101, 1765, 3273], 'K.S.': [1102, 1766, 3274], 'Aykin-Burns': [1103, 1767, 3275], 'N.': [1104, 1768, 3276], 'Pennington': [1105, 1763, 3277], 'J.D.': [1106, 1764, 3278], 'van': [1107, 3279], 'der': [1108, 3280], 'Meer': [1109, 3281], 'R.': [1110, 2000, 2085, 2402, 2442, 3282], 'Nguyen': [1111, 1775, 3283], 'Savage': [1113, 3285], 'Owens': [1115, 3287], 'K.M.': [1116, 1762, 3288], 'Vassilopoulos': [1117, 3289], 'Ozden': [1119, 3291], 'O.': [1120, 3292], 'Park': [1121, 3293], 'S.H.': [1122, 3294], 'Singh': [1123, 3295], 'K.K.': [1124, 3296], 'Abdulkadir': [1125, 3297], 'S.A.': [1126, 3298], 'Spitz': [1127, 1783, 3299], 'D.R.': [1128, 1784, 3300], 'Deng': [1129, 1781, 3301], 'C.X.': [1130, 1782, 3302], 'Gius': [1131, 1785, 3303], 'Cancer': [1133, 3305], 'Cell.': [1134, 2031, 3306], '17:': [1136, 3308], '41-52Abstract': [1137, 3309], '(619)': [1145, 3317], 'reports': [1149, 3321], 'SIRT3': [1153, 1919, 3325], 'polymorphisms': [1155, 3327], 'human': [1159, 3331], 'aging': [1160, 3332], '(14Rose': [1161, 3333], 'Dato': [1163, 1212, 3335, 3384], 'Altomare': [1165, 3337], 'Bellizzi': [1167, 3339], 'Garasto': [1169, 3341], 'Greco': [1171, 1217, 3343, 3389], 'V.': [1172, 1178, 1218, 1224, 2314, 3344, 3350, 3390, 3396], 'Passarino': [1173, 1227, 3345, 3399], 'Feraco': [1175, 1221, 3347, 3393], 'Mari': [1177, 1223, 3349, 3395], 'Barbi': [1179, 3351], 'BonaFe': [1181, 3353], 'Franceschi': [1183, 1225, 3355, 3397], 'Tan': [1185, 3357], 'Q.': [1186, 1302, 1744, 1887, 3358, 3474], 'Boiko': [1187, 3359], 'Yashin': [1189, 3361], 'A.I.': [1190, 3362], 'De': [1191, 1214, 1229, 3363, 3386, 3401], 'Benedictis': [1192, 1230, 3364, 3402], 'Exp.': [1194, 3366], 'Gerontol.': [1195, 3367], '38:': [1197, 3369], '1065-1070Crossref': [1198, 3370], '(240)': [1201, 3373], '15Bellizzi': [1204, 3376], 'Rose': [1206, 3378], 'Cavalcante': [1208, 3380], 'Covello': [1210, 3382], 'Rango': [1215, 3387], 'Maggiolini': [1219, 3391], 'Genomics.': [1232, 3404], '2005;': [1233, 1306, 1748, 1891, 3405, 3478], '85:': [1234, 3406], '258-263Crossref': [1235, 3407], '(299)': [1238, 3410], 'Scholar).Sirt3': [1240, 1651, 3412], 'tissue,': [1247, 2344, 3419], 'contrast': [1249, 3421], 'low': [1252, 3424], 'fat.': [1256, 3428], 'impaired': [1261, 1614, 1622, 3433], 'fat': [1264, 1294, 1429, 2072, 2366, 3436, 3466], 'rodents': [1266, 2159, 3438], 'under': [1267, 1689, 2119, 3439], 'conditions': [1268, 3440], 'diminished': [1270, 3442], 'obesity,': [1275, 3447], 'it': [1277, 1340, 1685, 1818, 2142, 2370, 3449, 3512], 'has': [1278, 1727, 2160, 3450], 'proposed': [1280, 1834, 3452], '(16Shi': [1295, 1737, 1880, 3467], 'Wang': [1297, 1739, 1882, 2441, 3469], 'Stieren': [1299, 1741, 1884, 3471], 'Tong': [1301, 1743, 1886, 3473], '280:': [1307, 1749, 1892, 3479], '13560-13567Abstract': [1308, 1750, 1893, 3480], '(566)': [1316, 1758, 1901, 3488], 'Scholar).In': [1318, 3490], 'study,': [1321, 3493], 'report': [1323, 3495], 'PGC-1α': [1325, 3497], 'controller': [1329, 3501], 'gene.': [1336, 3508], 'By': [1337, 3509], 'means,': [1339, 3511], 'contributes': [1341, 1567, 3513], 'capacity': [1348, 1719, 2113, 2339, 3520], 'cell.DISCUSSIONComplex': [1353], 'program': [1361, 1546], 'differentiated,': [1368], 'thermogenically': [1369], 'competent': [1370, 1587], 'adipocytes.': [1372, 1589], 'This': [1373, 2478], 'differentiation': [1374, 1583, 2150], 'process': [1375, 2527], 'allows': [1376], 'perform': [1380], 'activation.': [1392], 'known': [1398, 2145, 2256], 'play': [1400], 'master': [1402, 2539], 'eliciting': [1405], 'coordinate': [1407], 'leads': [1413], 'Increasing': [1418], 'drive': [1422], 'Moreover,': [1461, 2123], 'sensitivity': [1471, 1599], 'noradrenergic-stimulated': [1473], 'Our': [1503], 'findings,': [1505], 'constitute': [1507], 'first': [1509], 'analysis': [1510], 'effect': [1527], 'observations': [1536], 'indicating': [1537], 'unable': [1541], 'lack': [1554, 2135], 'indicates': [1556], 'be': [1563, 1820, 2098, 2139, 2281, 2486, 2529], 'mechanism': [1565], 'ability': [1570], 'widespread': [1576], 'effects': [1578], 'requirement': [1592], 'complete': [1608], 'agreement': [1609], 'observation': [1612], 'responses': [1615], 'deacetylase': [1655], 'family,': [1659], 'considered': [1662, 1821], 'intracellular': [1665, 2532], 'biological': [1666], 'processes': [1667], 'de-acetylating': [1669], 'target': [1670], 'proteins': [1671], 'It': [1678, 1799], 'localized': [1680], 'and,': [1684], 'controversial': [1687], 'whether': [1688, 1802, 2102, 2146], 'circumstances,': [1691], 'nucleus': [1694], 'influence': [1723], 'several': [1731], 'models,': [1733], '26Jacobs': [1761], 'Mishra': [1771], 'Sun': [1773], 'Ahn': [1777], 'B.H.': [1778], 'Leclerc': [1779], 'Int.': [1787], '2008;': [1791, 2192], '4:': [1792], '291-299Crossref': [1793], '(210)': [1796], 'unknown': [1801], 'due': [1805], 'from': [1808, 2073], '(the': [1812], 'so-called': [1813], 'reverse': [1815], 'signaling)': [1816], 'should': [1819], 'direct': [1823], 'consequence': [1824], 'potential': [1827], 'presence': [1828], 'nuclei,': [1832], 'some': [1836], 'authors': [1837], '(7Scher': [1838], 'Shi': [1877], 'et': [1878, 1987, 2437], 'al.': [1879, 1988, 2438], 'acts': [1907], 'increasing': [1909], 'cAMP-response': [1910], 'element-binding': [1911], 'phosphorylation,': [1913], 'targets': [1917], 'deacetylation': [1920], 'actors': [1923], 'not': [1935, 2144, 2488], 'identified': [1937], 'date.': [1939], 'any': [1941], 'case,': [1942], 'our': [1943], 'findings': [1945, 2415], 'phenotype,': [1959], 'functionally': [1962], 'Pgc-1α-mediated': [1970], 'activation.Although': [1972], 'few': [1973], 'studies': [1974, 2096], 'conducted': [1977], 'thermoregulation': [1980], 'mice': [1983, 2075, 2118, 2294], 'vivo,': [1985], '(27Lombard': [1989], 'Cheng': [1993], 'H.L.': [1994], 'Streeper': [1997], 'R.S.': [1998], 'Mostoslavsky': [1999], 'Yancopoulos': [2003], 'Valenzuela': [2005], 'Murphy': [2007], 'Chen': [2011, 2449], 'Bronson': [2015], 'R.T.': [2016], 'Haigis': [2017], 'Guarente': [2019], 'L.P.': [2020], 'Weissman': [2024], '8807-8814Crossref': [2035], '(949)': [2038], 'short-term': [2046], 'exposure': [2048], 'was': [2049], 'unaltered': [2050], 'these': [2052], 'mice.': [2053], 'However,': [2054], 'observed': [2056], 'thermal': [2059], 'stress-induced': [2060], 'postnatal': [2061], 'significantly': [2068], 'reduced': [2069], 'Sirt3-KO': [2074], '(28Villarroya': [2076], 'Giralt': [2078, 2086], 'Planavila': [2080], 'Hondares': [2082], 'Iglesias': [2084], '59:': [2092], '279Google': [2093], 'Further': [2095], 'will': [2097], 'needed': [2099, 2332], 'inactivation': [2103], 'vivo': [2109], 'influences': [2110], 'adaptive': [2115], 'distinct': [2120], 'physiological': [2121, 2506], 'conditions.': [2122], 'possibility': [2125], 'sirtuins': [2128], 'Sirt1)': [2130], 'might': [2131], 'compensate': [2132], 'cannot': [2138], 'excluded.': [2140], 'Although': [2141], 'Sirt1': [2147, 2157], 'affects': [2148], 'BAT': [2149], 'responsiveness,': [2153], 'chronic': [2154], '(29Feige': [2170], 'J.N.': [2171], 'Lagouge': [2172], 'Canto': [2174], 'Strehle': [2176], 'Houten': [2178], 'S.M.': [2179], 'Milne': [2180], 'J.C.': [2181], 'Lambert': [2182], 'P.D.': [2183], 'Mataki': [2184], 'Elliott': [2186], 'P.J.': [2187], 'Auwerx': [2188], '8:': [2193], '347-358Abstract': [2194], '(608)': [2202], 'Scholar).Although': [2204], 'potentially': [2207], 'coactivate': [2208], 'at': [2217, 2361], 'appears': [2221, 2279], 'involve': [2223], 'mainly': [2224], 'Errα.': [2229], 'factor': [2237], 'being': [2238], 'coactivated': [2239], 'driving': [2245], 'consistent': [2253], 'preferentially': [2273], 'mitochondria.': [2277], 'adaptation': [2284], 'environment,': [2287], 'evidenced': [2289], 'failure': [2292], 'maintain': [2298], 'body': [2299], 'temperature': [2300], 'exposed': [2302], '(30Villena': [2305], 'J.A.': [2306], 'Hock': [2307], 'Chang': [2309, 2453], 'W.Y.': [2310], 'Barcas': [2311], 'J.E.': [2312], 'Giguère': [2313], 'Kralli': [2315], '104:': [2323], '1418-1423Crossref': [2324], '(161)': [2327], 'oxidative': [2338], 'thus': [2346], 'providing': [2348], 'necessary': [2351], 'thermogenesis.': [2353, 2510], 'fulfills': [2355], 'acting': [2359], 'directly': [2360], 'thermogenesis:': [2367], 'one': [2372], 'interact': [2378], 'mediate': [2382], '(31Debevec': [2389], 'Christian': [2391], 'Morganstein': [2393], 'Seth': [2395], 'Herzog': [2397], 'Parker': [2399], 'White': [2401], 'Endocrinol.': [2404], '1581-1592Crossref': [2407], '(79)': [2410], 'demonstrate': [2416], 'promotion': [2423], 'During': [2430], 'preparation': [2432], 'article,': [2435], 'Kong': [2436], '(32Kong': [2439], 'X.': [2440, 2446], 'Xue': [2443], 'Liu': [2445], 'Zhang': [2447], 'H.': [2448], 'Fang': [2451], 'PLoS.': [2455], 'One.': [2456], '5:': [2458], 'e11707Crossref': [2459], '(539)': [2462], 'context': [2474], 'muscle': [2476], 'cells.': [2477], 'confirms': [2479], 'Pgc-1α-Sirt3': [2482], 'regulatory': [2483], 'axis': [2484], 'only': [2489], 'also': [2494], 'types': [2498], 'functions': [2502], 'regulated': [2504], 'purposes': [2507], 'than': [2509], 'summary,': [2512], 'conclude': [2514], 'relevant': [2531], 'conducts': [2537]}, 'cited_by_api_url': 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