Title: The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA
Abstract: The effect of fasting on palmitoyl-CoA : carnitine palmitoyltransferase (EC 2.3.1.21) in rat liver mitochondria and its inhibition by malonyl-CoA has been investigated. The activity of the outer carnitine pahnitoyltransferase (transferase I) is nearly doubled after 24 h fasting, while the activity of total carnitine pahnitoyltransferase (transferase I + II) increases only about 25%. The inhibition of the increased outer transferase by malonyl-CoA is decreased in fasting rats. The results suggest that carnitine pahnitoyltransferase less sensitive to malonyl-CoA is exposed on the outer surface of the inner mitochondrial membrane in fasting, thus reducing the latency of the enzyme.
Publication Year: 1981
Publication Date: 1981-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 249
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