Title: Aspects of development of imaginal discs in a non-pupariating lethal mutant in Drosophila melanogaster
Abstract: Abstract Imaginal discs from a non-pupariating mutant, lethal-1 a , were cultured in vitro. Responses of the discs to B-ecdysone are abnormal, including failure to maintain an increased level of RNA synthesis, depression of protein synthesis and cell death. When lethal-1 a discs are transplanted into wild-type larvae for metamorphosis, almost all bristle-forming regions fail to differentiate, whereas non-bristle-forming regions do so normally. Mutant larvae apparently secrete molting hormone, and can synthesize cuticle within unevaginated discs. The in vitro experiments suggest that abnormal responses of mutant tissue to β-ecdysone in situ result in non-pupariation, failure to disc evagination and death.
Publication Year: 1977
Publication Date: 1977-12-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 7
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