Inhibition of Tumor Invasion by Genomic Down-regulation of Matriptase through Suppression of Activation of Receptor-bound Pro-urokinase

Name: Work Video:
Duration: 3 min 30 s
Mika Suzuki; Hiroshi Kobayashi; Naohiro Kanayama; Yasushi Saga; Mitsuaki Suzuki; Chen‐Yong Lin; Robert B. Dickson; Toshihiko Terao
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'https://openalex.org/W1982507315', 'https://openalex.org/W1990221290', 'https://openalex.org/W1991188859', 'https://openalex.org/W1992457807', 'https://openalex.org/W1999600269', 'https://openalex.org/W2014130375', 'https://openalex.org/W2014438829', 'https://openalex.org/W20164601', 'https://openalex.org/W2027077679', 'https://openalex.org/W2038372720', 'https://openalex.org/W2039135880', 'https://openalex.org/W2040663639', 'https://openalex.org/W2044896610', 'https://openalex.org/W2044949296', 'https://openalex.org/W2046143615', 'https://openalex.org/W2053399280', 'https://openalex.org/W2054689493', 'https://openalex.org/W2059538895', 'https://openalex.org/W2061064073', 'https://openalex.org/W2069849774', 'https://openalex.org/W2078119356', 'https://openalex.org/W2087068775', 'https://openalex.org/W2095847870', 'https://openalex.org/W2096025008', 'https://openalex.org/W2099074143', 'https://openalex.org/W2119542456', 'https://openalex.org/W2138490473', 'https://openalex.org/W2144185179', 'https://openalex.org/W2154484742', 'https://openalex.org/W2161892290', 'https://openalex.org/W2396086641', 'https://openalex.org/W2412586413', 'https://openalex.org/W2417854378', 'https://openalex.org/W338201279', 'https://openalex.org/W64336563'], 'related_works': ['https://openalex.org/W2298336297', 'https://openalex.org/W2223554765', 'https://openalex.org/W2109030321', 'https://openalex.org/W2066250328', 'https://openalex.org/W2046953700', 'https://openalex.org/W2015711783', 'https://openalex.org/W2003795615', 'https://openalex.org/W1589132608', 'https://openalex.org/W1542148298', 'https://openalex.org/W101610969'], 'abstract_inverted_index': {'Urokinase-type': [0, 190], 'plasminogen': [1, 191, 416, 425, 487], 'activator': [2, 192, 417, 4060], '(uPA)': [3, 193, 418], 'degrades': [4, 194], 'the': [5, 46, 65, 133, 163, 172, 195, 236, 255, 323, 353, 362, 389, 408, 503, 517, 582, 601, 634, 807, 811, 858, 1053, 1117, 1130, 1292, 1718, 1725, 1789, 1817, 1844, 1847, 1945, 2228, 2237, 2245, 2253, 2264, 2293, 2326, 2440, 2546, 2553, 2558, 2738, 2772, 2781, 2787, 2847, 2888, 2901, 2963, 3033, 3042, 3103, 3300, 3311, 3323, 3327, 3377, 3381, 3386, 3403, 3435, 3534, 3552, 3597, 3602, 3676, 3736, 3741, 3745, 3787, 3796, 3845, 3920, 3923, 3943, 3998, 4031, 4206, 4326, 4338, 4346], 'extracellular': [6, 153, 196, 343, 383, 440, 509], 'matrix': [7, 154, 197, 344, 384, 490, 510], 'and': [8, 15, 43, 56, 95, 99, 198, 205, 233, 246, 285, 289, 382, 501, 513, 603, 651, 669, 686, 690, 815, 817, 866, 872, 875, 878, 1034, 1052, 1061, 1125, 1266, 1273, 1405, 1474, 1486, 1500, 1642, 1731, 1739, 1803, 1841, 1856, 1886, 1907, 1910, 1920, 1923, 1929, 1938, 1960, 2013, 2052, 2072, 2089, 2102, 2112, 2131, 2180, 2261, 2284, 2317, 2334, 2396, 2407, 2448, 2508, 2631, 2740, 2851, 2887, 2955, 2969, 3024, 3039, 3111, 3171, 3185, 3194, 3297, 3322, 3380, 3416, 3443, 3450, 3467, 3563, 3583, 3590, 3601, 3626, 3640, 3672, 3683, 3686, 3739, 3770, 3885, 3905, 3915, 3922, 3942, 3951, 3965, 3991, 4020, 4054, 4106, 4148, 4169, 4179, 4211, 4225, 4246, 4267, 4286, 4302], 'plays': [9, 199, 492], 'critical': [10, 200, 494], 'roles': [11, 201, 1401, 1794], 'in': [12, 27, 54, 59, 75, 132, 202, 217, 244, 249, 265, 322, 392, 496, 502, 684, 870, 873, 881, 1069, 1282, 1298, 1305, 1402, 1711, 1795, 2165, 2184, 2219, 2227, 2244, 2292, 2359, 2439, 2443, 3172, 3196, 3199, 3402, 3434, 3472, 3512, 3533, 3575, 3610, 3706, 3719, 3735, 3740, 3800, 3862, 3919, 3983, 4131, 4145, 4154, 4191, 4200, 4205, 4223, 4234, 4278, 4314, 4356], 'tumor': [13, 57, 203, 247, 587, 879, 1059, 1062, 1284, 1406, 1736, 1820], 'invasion': [14, 204, 385, 685, 1124, 1738, 1802, 2029, 2033, 3170], 'metastasis.': [16, 206, 1740, 1804], 'Matriptase,': [17, 207, 1367], 'a': [18, 28, 83, 147, 180, 208, 218, 273, 337, 370, 493, 597, 647, 652, 1046, 1075, 1139, 1303, 1368, 1461, 1465, 1470, 1501, 1749, 2410, 2451, 2561, 2663, 2698, 2701, 2868, 2988, 3200, 3316, 3372, 3410, 3461, 3617, 3707, 3837, 3968, 4039, 4305, 4318, 4357], 'membrane-bound': [19, 209, 3782], 'serine': [20, 210, 1268, 1372, 1503], 'protease,': [21, 211], 'was': [22, 70, 212, 260, 1315, 1863, 1874, 2047, 2122, 2142, 2163, 2222, 2307, 2461, 2521, 2735, 2972, 3161, 3192, 3400, 3605, 3614, 3650, 3733, 3784, 3852, 3945, 4026, 4047, 4076, 4118, 4238, 4328], 'shown': [23, 213, 413, 1111], 'to': [24, 45, 120, 138, 150, 214, 235, 310, 328, 340, 639, 681, 1072, 1302, 1324, 1605, 1850, 1897, 2310, 2422, 2530, 2778, 3032, 3109, 3299, 3407, 3542, 3849, 3881, 3967, 4056, 4121, 4270, 4299, 4330, 4345], 'activate': [25, 215, 1611, 1813], 'uPA': [26, 29, 42, 68, 94, 96, 216, 219, 232, 258, 284, 286, 453, 579, 607, 629, 637, 689, 814, 865, 1646, 1881, 1884, 1890, 1896, 1958, 1965, 2596, 3180, 3191, 3248, 3303, 3319, 3368, 3724, 3732, 3747, 3763, 3769, 3775, 3783], 'receptor-free,': [30, 220], 'solution-based': [31, 221], 'study.': [32, 222, 2977], 'We': [33, 223, 1014], 'now': [34, 224], 'investigate': [35, 225], 'whether': [36, 103, 226, 293, 1810], 'matriptase': [37, 119, 127, 184, 227, 309, 317, 374, 1257, 1314, 1321, 1653, 1716, 1786, 1811, 1828, 1983, 2548, 3035], 'affects': [38, 228], 'activation': [39, 89, 135, 186, 229, 279, 325, 376], 'of': [40, 48, 86, 93, 102, 136, 187, 230, 238, 276, 283, 292, 326, 377, 388, 432, 505, 578, 585, 606, 677, 797, 813, 1026, 1057, 1116, 1133, 1190, 1235, 1262, 1295, 1652, 1706, 1743, 1819, 1827, 1846, 1852, 1895, 1905, 1948, 2247, 2258, 2266, 2271, 2297, 2362, 2491, 2533, 2560, 2743, 2783, 2966, 3041, 3045, 3190, 3383, 3432, 3437, 3440, 3455, 3506, 3531, 3538, 3544, 3570, 3586, 3675, 3689, 3723, 3731, 3768, 3774, 3780, 3789, 3798, 3847, 3859, 3925, 4041, 4086, 4166, 4183, 4203, 4208, 4320], 'receptor-bound': [41, 87, 112, 188, 231, 277, 302, 378, 1814], 'contributes': [44, 234], 'invasiveness': [47, 237, 820, 877], 'HRA': [49, 76, 239, 266, 805, 882, 1150, 1299, 1836, 1854, 2898, 2980, 3242, 3306, 3404], 'human': [50, 240, 800, 1861, 2045, 2703, 3034, 3317], 'ovarian': [51, 241, 801, 2158, 2272], 'cancer': [52, 242, 393, 506, 802, 1801, 2159, 2273], 'cells': [53, 104, 145, 165, 243, 294, 335, 355, 883, 1022, 1151, 1300, 1837, 1855, 2224, 2356, 2437, 2899, 2981, 2984, 3110, 3243, 3307, 3511, 3553, 3574, 3598, 3609, 3623, 3635, 3714, 3860, 3891, 4171, 4197, 4334], 'vitro': [55, 245, 871, 1070], 'behavior': [58, 248], 'nude': [60, 170, 250, 360, 2058], 'mice.': [61, 251], 'Here': [62, 252], 'we': [63, 253, 1041, 1108, 1136, 1833, 1842], 'show': [64, 254, 1288], 'following.': [66, 256], '1)': [67, 257], 'expression': [69, 92, 259, 282, 676, 812, 868, 1293, 1742, 2883, 2949, 3205, 3312, 3369, 3397], 'effectively': [71, 261], 'stimulated': [72, 106, 262, 296], 'by': [73, 118, 263, 308, 515, 695, 861, 1067, 1123, 1318, 1721, 1732, 2252, 2498, 2526, 2864, 2900, 2952, 3556, 3607, 3786, 3795, 3844, 3963, 3971, 4028, 4049, 4065, 4188, 4240, 4265, 4294], 'TGF-β1': [74, 264, 2046, 2221, 2300], 'cells.': [77, 160, 267, 350, 1031, 1821], '2)': [78, 268], 'Antisense': [79, 269, 3021, 3027, 3179], '(AS)-matriptase': [80, 270], 'transfection': [81, 271, 796, 3395], 'achieved': [82, 272, 4048], 'marked': [84, 274], 'inhibition': [85, 275], 'pro-uPA': [88, 113, 137, 278, 303, 327, 1815, 3848], 'without': [90, 280, 2343, 4284], 'altering': [91, 281], 'receptor': [97, 287, 592, 1496, 1639, 1927, 3851], 'mRNA': [98, 288, 1145], 'proteins,': [100, 290], 'irrespective': [101, 291], 'were': [105, 166, 295, 356, 692, 1193, 1648, 1966, 2016, 2035, 2062, 2076, 2083, 2105, 2117, 2134, 2153, 2225, 2234, 2250, 2276, 2330, 2349, 2357, 2415, 2428, 2446, 2496, 2542, 2657, 2769, 2849, 2862, 2895, 2950, 2985, 3037, 3094, 3106, 3166, 3244, 3308, 3426, 3458, 3497, 3526, 3554, 3578, 3599, 3624, 3636, 3665, 3695, 3704, 3715, 3757, 3867, 3903, 3961, 3975, 3995, 4062, 4091, 4129, 4172, 4198, 4221, 4263, 4275, 4296, 4312, 4335, 4353], 'with': [107, 158, 297, 348, 581, 599, 806, 1029, 1748, 1785, 1838, 1889, 1893, 1918, 1926, 2172, 2187, 2280, 2286, 2341, 2351, 2409, 2456, 2524, 2771, 2873, 2945, 3091, 3114, 3246, 3310, 3396, 3429, 3469, 3528, 3559, 3580, 3628, 3638, 3652, 3669, 3836, 3870, 3876, 3893, 3908, 3997, 4030, 4093, 4175, 4242, 4249, 4282], 'TGF-β1.': [108, 298], '3)': [109, 299], 'Tumor': [110, 300, 1565], 'cell': [111, 301, 394, 484, 507, 588, 635, 803, 1063, 1306, 1403, 1407, 1729, 1737, 1796, 2028, 2160, 2248, 2274, 2312, 2338, 2424, 3405, 3647, 3742, 3855, 3953, 3959], 'could': [114, 304, 641], 'be': [115, 305, 631, 682, 1325], 'efficiently': [116, 306], 'cleaved': [117, 307], 'generate': [121, 311], 'enzymatically': [122, 139, 312, 329, 1643], 'active': [123, 140, 313, 330, 604, 1607], 'two-chain': [124, 314, 1964], 'uPA.': [125, 141, 189, 315, 331, 379], 'Thus,': [126, 316, 1783], 'can': [128, 318, 630, 1599, 1610, 1812], 'substitute': [129, 319], 'for': [130, 183, 185, 320, 373, 375, 593, 2301, 2332, 2346, 2404, 2774, 2780, 2878, 3096, 3168, 3642, 3661, 3697, 3873, 3897, 3936, 3977, 4043, 4110, 4138, 4214, 4228, 4289, 4309], 'plasmin': [131, 321, 1930, 1936, 1943], 'proteolytic': [134, 324], '4)': [142, 332], 'The': [143, 333, 1704, 1741, 1878, 2057, 2127, 2241, 2304, 2337, 2538, 3163, 3241, 3367, 3729, 3762, 3840, 3890, 4236, 4261, 4273, 4323], 'AS-matriptase-treated': [144, 164, 334, 354], 'had': [146, 336], 'decreased': [148, 338], 'ability': [149, 339], 'invade': [151, 341, 1073], 'an': [152, 342, 1326, 3539], 'layer,': [155, 345], 'as': [156, 346, 1065, 1121, 1239, 1260, 1650, 1709, 1724, 1735, 1798, 1800, 2464, 2544, 2659, 2907, 2987, 3176, 3257, 3409, 3806, 4360], 'compared': [157, 347, 1028, 1843], 'control': [159, 349, 2559, 2889, 2989, 3657], '5)': [161, 351], 'When': [162, 352], 'injected': [167, 357], 'intraperitoneally': [168, 358], 'into': [169, 359, 2552, 2897], 'mice,': [171, 361], 'mice': [173, 363, 2059], 'developed': [174, 364], 'smaller': [175, 365], 'tumors.': [176, 366], 'Our': [177, 367], 'data': [178, 368, 1808], 'identify': [179, 369], 'novel': [181, 371], 'role': [182, 372, 495], 'Cell': [380, 526, 2156, 2262, 2413, 3025, 3412, 4310], 'migration': [381, 1404, 1797], 'are': [386, 1806], 'some': [387], 'major': [390], 'steps': [391], 'metastasis': [395, 514, 1408], '(1Kohn': [396], 'E.C.': [397], 'Liotta': [398], 'L.A.': [399], 'Cancer': [400, 1776, 3234], 'Res.': [401, 1777, 2759, 3235], '1995;': [402, 3362, 3823], '55:': [403], '1856-1862PubMed': [404], 'Google': [405, 536, 549, 571, 626, 663, 718, 744, 767, 793, 850, 912, 946, 976, 1012, 1101, 1186, 1229, 1365, 1396, 1429, 1457, 1530, 1551, 1573, 1596, 1635, 1674, 1702, 1781, 2008, 2214, 2488, 2594, 2629, 2655, 2693, 2733, 2766, 2810, 2843, 2939, 3019, 3087, 3147, 3239, 3278, 3295, 3350, 3365, 3493, 3834, 4386], 'Scholar).': [406, 537, 627, 664, 794, 851, 1013, 1102, 1187, 1230, 1366, 1458, 1597, 1636, 1703, 1782, 2009, 2215, 2489, 2595, 2767, 2844, 2940, 3020, 3088, 3148, 3240, 3366, 3494], 'In': [407, 671, 1039, 1103, 2324, 2435], 'past,': [409], 'several': [410, 678, 1018, 1236, 1296], 'investigators': [411], 'have': [412, 573, 854, 1109, 1278], 'that': [414, 575, 1017, 1043, 1112, 1289, 1313, 1715, 1788], 'urokinase-type': [415, 424], '1The': [419], 'abbreviations': [420], 'used': [421, 2331, 2543, 2974, 2986, 3167, 3641], 'are:': [422], 'uPA,': [423, 594, 1733, 3884], 'activator;': [426, 488], 'AS,': [427], 'antisense;': [428], 'ATF,': [429], 'amino-terminal': [430, 1467, 3591], 'fragment': [431, 2666, 3189, 3375, 3592], 'uPA;': [433], 'bikunin-R,': [434], 'bikunin': [435, 698, 808, 863, 1027, 1050, 1113, 1290, 1328, 1858, 1862, 2882, 2947, 2967], 'receptor;': [436, 454], 'DFP,': [437], 'diisopropylfluorophosphate;': [438], 'ECM,': [439], 'matrix;': [441], 'HMW-uPA,': [442], 'high': [443, 1961, 3419], 'molecular': [444, 448, 859, 1962, 2517, 3420], 'weight-uPA;': [445, 449], 'LMW-uPA,': [446, 3589], 'low': [447, 1493], 'S,': [450], 'sense;': [451], 'uPAR,': [452, 595, 691], 'PBS,': [455, 3871], 'phosphate-buffered': [456, 2281], 'saline;': [457], 'TGF-β,': [458], 'transforming': [459], 'growth': [460, 880, 1484, 1602, 3154], 'factor-β;': [461], 'BSA,': [462], 'Bovine': [463, 2093], 'serum': [464, 2075, 2094, 3160], 'albumin;': [465], 'MTT,': [466], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [467], 'bromide;': [468], 'GAPDH,': [469], 'glyceraldehyde-3-phosphate': [470, 2775], 'dehydrogenase;': [471], 'ELISA,': [472], 'enzyme-linked': [473], 'immunosorbent': [474], 'assay;': [475], 'PVDF,': [476], 'polyvinylidene': [477, 2113], 'difluoride;': [478], 'PI3K,': [479], 'phosphoinositide': [480, 1274], '3-kinase;': [481], 'FACS,': [482], 'fluorescence-activated': [483], 'sorter;': [485], 'PA,': [486], 'MMP,': [489], 'metalloproteinase.': [491], 'embryogenesis,': [497], 'tissue': [498, 3864], 'remodeling,': [499], 'inflammation,': [500], 'regulation': [504], 'migration,': [508], '(ECM)': [511], 'invasion,': [512], 'degrading': [516], 'ECM': [518, 3169, 4349], 'proteins': [519, 679], '(2Andreasen': [520], 'P.A.': [521, 2708, 2748], 'Egelund': [522], 'R.': [523, 1970, 2714, 2716, 3123], 'Petersen': [524], 'H.H.': [525], 'Mol.': [527], 'Life': [528], 'Sci.': [529, 1541, 3137], '2000;': [530, 901, 1418, 1446, 1624, 1663, 1691], '57:': [531], '25-40Crossref': [532], 'PubMed': [533, 548, 568, 625, 715, 741, 764, 790, 847, 909, 943, 973, 1009, 1098, 1183, 1226, 1362, 1393, 1426, 1454, 1527, 1548, 1570, 1593, 1632, 1671, 1699, 2005, 2211, 2485, 2591, 2626, 2652, 2690, 2730, 2763, 2807, 2840, 2936, 3016, 3084, 3144, 3277, 3292, 3349, 3492, 3831, 4383], 'Scopus': [534, 569, 716, 742, 765, 791, 848, 910, 944, 974, 1010, 1099, 1184, 1227, 1363, 1394, 1427, 1455, 1528, 1549, 1571, 1594, 1633, 1672, 1700, 2006, 2212, 2486, 2592, 2627, 2653, 2691, 2731, 2764, 2808, 2841, 2937, 3017, 3085, 3145, 3293, 3832, 4384], '(843)': [535], 'Several': [538], 'reports': [539], '(3Duffy': [540], 'M.J.': [541], 'Biochem.': [542, 619, 760, 2481, 2648, 2803], 'Soc.': [543, 620], 'Trans.': [544, 621], '2002;': [545, 622, 761, 782, 965, 1778, 2203, 2482, 2649, 2804], '30:': [546, 623], '207-210Crossref': [547], 'Scholar,': [550, 719, 745, 768, 913, 947, 977, 1430, 1531, 1552, 1574, 1675, 2811, 3279, 3351, 4387], '4Muehlenweg': [551], 'B.': [552, 1762, 3357], 'Sperl': [553], 'S.': [554, 1543, 2609, 2617, 2823, 2831, 3139, 3208, 3283], 'Magdolen': [555], 'V.': [556], 'Schmitt': [557], 'M.': [558, 609, 700, 723, 749, 755, 772, 822, 836, 891, 895, 919, 925, 929, 949, 953, 957, 979, 993, 1083, 1087, 1153, 1167, 1196, 1210, 1332, 1346, 1511, 1764, 1989, 2193, 2470, 2476, 2605, 2637, 2643, 2792, 2798, 2819, 2911, 2925, 2991, 3005, 3054, 3068, 3121, 3127, 3133, 3228, 4365], 'Harbeck': [559], 'N.': [560, 751, 776, 830, 923, 959, 987, 1085, 1161, 1204, 1340, 2197, 2472, 2639, 2794, 2919, 2999, 3062, 3214], 'Expert.': [561], 'Opin.': [562], 'Biol.': [563, 731, 780, 899, 933, 963, 999, 1173, 1216, 1352, 1383, 1416, 1444, 1517, 1566, 1622, 1661, 1689, 1995, 2201, 2581, 3074, 3821, 4373], 'Ther.': [564], '2001;': [565, 660, 712, 733, 935, 1385, 1567, 2583, 3236, 4375], '1:': [566], '683-691Crossref': [567], '(66)': [570], 'Scholar)': [572, 2630, 2656, 3296, 3835], 'indicated': [574, 2347], 'increased': [576], 'levels': [577, 1025, 1826, 3756], 'correlate': [580], 'invasive': [583, 799, 1119, 1751], 'properties': [584, 1845], 'certain': [586], 'types.': [589], 'A': [590, 1188, 1498, 1976, 3393, 3645], 'specific': [591, 2531], 'forms': [596, 605, 1904, 3767], 'complex': [598], 'both': [600, 869], 'inactive': [602, 1644], '(5Ploug': [608], 'Gardsvoll': [610], 'H.': [611, 657, 702, 721, 747, 770, 824, 838, 885, 917, 951, 981, 995, 1035, 1081, 1091, 1155, 1169, 1198, 1212, 1334, 1348, 1554, 1772, 2191, 2468, 2599, 2635, 2670, 2672, 2674, 2790, 2813, 2913, 2927, 2993, 3007, 3056, 3070, 4363], 'Jorgensen': [612], 'T.J.': [613, 1564], 'Hansen': [614, 3354], 'Lonborg': [615], 'L.': [616], 'Dano': [617, 2723], 'K.': [618, 1560, 2607, 2611, 2724, 2754, 2821, 2825], '177-183Crossref': [624], 'Receptor-bound': [628, 4167], 'activated': [632], 'on': [633, 856, 1816, 2853, 3460, 3659, 3700, 3854, 4123], 'surface.': [636], 'binding': [638, 1894, 3502, 3513, 3561, 3576, 3613, 3629, 3670, 3846], 'uPAR': [640, 816, 867, 1914, 2632, 3632], 'enhance': [642], 'cellular': [643, 675, 819], 'invasiveness.': [644], 'Bikunin': [645, 2880], 'is': [646, 1045, 1114, 1322, 1746, 1980, 3633], 'Kunitz-type': [648], 'protease': [649, 1373, 1504, 1745, 1790], 'inhibitor': [650], 'heavily': [653], 'glycosylated': [654], 'protein': [655, 666, 1489, 2242, 2255, 2948], '(6Kobayashi': [656], 'Hum.': [658], 'Cell.': [659], '14:': [661], '233-236PubMed': [662], 'This': [665, 1231, 4025], 'inhibits': [667, 1942], 'trypsin': [668], 'plasmin.': [670], 'our': [672], 'previous': [673], 'experiments,': [674, 3175], 'known': [680, 1259], 'involved': [683], 'metastasis,': [687], 'including': [688], 'significantly': [693], 'suppressed': [694], 'exogenously': [696], 'added': [697, 3108, 3696], '(7Suzuki': [699], 'Kobayashi': [701, 823, 916, 950, 980, 1080, 1154, 1197, 1333, 2912, 2992, 3055], 'Tanaka': [703, 724, 773, 825, 920, 982, 1156, 1199, 1335, 2194, 2614, 2828, 2914, 2994, 3057, 4366], 'Y.': [704, 706, 725, 727, 774, 826, 828, 832, 834, 887, 915, 921, 983, 985, 989, 991, 1079, 1157, 1159, 1163, 1165, 1200, 1202, 1206, 1208, 1336, 1338, 1342, 1344, 1558, 2195, 2601, 2615, 2815, 2829, 2915, 2917, 2921, 2923, 2995, 2997, 3001, 3003, 3058, 3060, 3064, 3066, 3216, 4367, 4369], 'Hirashima': [705, 726, 827, 886, 984, 1033, 1158, 1201, 1337, 2600, 2814, 2916, 2996, 3059, 4368], 'Terao': [707, 728, 756, 777, 839, 896, 930, 960, 996, 1092, 1170, 1213, 1349, 2198, 2477, 2618, 2644, 2799, 2832, 2928, 3008, 3071, 4370], 'T.': [708, 729, 753, 757, 778, 840, 893, 897, 927, 931, 955, 961, 997, 1089, 1093, 1171, 1214, 1350, 1432, 1533, 1677, 2199, 2474, 2478, 2619, 2641, 2645, 2752, 2796, 2800, 2833, 2929, 3009, 3072, 4371], 'Biochim.': [709, 2620, 2834], 'Biophys.': [710, 2621, 2835], 'Acta.': [711, 2622, 2836], '1547:': [713], '26-36Crossref': [714], '(32)': [717], '8Kobayashi': [720], 'Suzuki': [722, 748, 771, 835, 918, 992, 1082, 1086, 1166, 1209, 1345, 2192, 2469, 2636, 2791, 2924, 3004, 3067, 4364], 'J.': [730, 759, 779, 842, 898, 932, 962, 998, 1172, 1215, 1351, 1382, 1415, 1443, 1509, 1516, 1621, 1660, 1688, 1987, 1994, 2200, 2480, 2580, 2647, 2686, 2802, 2931, 3011, 3073, 3262, 3287, 3334, 3477, 3813, 3820, 4372], 'Chem.': [732, 781, 900, 934, 964, 1000, 1174, 1217, 1353, 1384, 1417, 1445, 1518, 1623, 1662, 1690, 1996, 2202, 2582, 3075, 3822, 4374], '276:': [734, 936, 1386, 2584, 4376], '2015-2022Abstract': [735, 4377], 'Full': [736, 738, 785, 787, 904, 906, 938, 940, 968, 970, 1004, 1006, 1178, 1180, 1221, 1223, 1357, 1359, 1388, 1390, 1421, 1423, 1449, 1451, 1522, 1524, 1627, 1629, 1666, 1668, 1694, 1696, 2000, 2002, 2206, 2208, 2586, 2588, 3079, 3081, 3826, 3828, 4378, 4380], 'Text': [737, 739, 786, 788, 905, 907, 939, 941, 969, 971, 1005, 1007, 1179, 1181, 1222, 1224, 1358, 1360, 1389, 1391, 1422, 1424, 1450, 1452, 1523, 1525, 1628, 1630, 1667, 1669, 1695, 1697, 2001, 2003, 2207, 2209, 2587, 2589, 3080, 3082, 3827, 3829, 4379, 4381], 'PDF': [740, 789, 908, 942, 972, 1008, 1182, 1225, 1361, 1392, 1425, 1453, 1526, 1631, 1670, 1698, 2004, 2210, 2590, 3083, 3830, 4382], '(71)': [743, 4385], '9Kobayashi': [746], 'Kanayama': [750, 775, 829, 922, 958, 986, 1084, 1160, 1203, 1339, 2196, 2471, 2638, 2793, 2918, 2998, 3061], 'Nishida': [752, 892, 926, 954, 2473, 2640, 2795], 'Takigawa': [754, 894, 928, 956, 2475, 2642, 2797], 'Eur.': [758, 2479, 2646, 2801], '269:': [762, 2483, 2650, 2805], '3945-3957Crossref': [763, 2484, 2651, 2806], '(38)': [766, 2487, 2654, 2809], '10Kobayashi': [769], '278:': [783, 1002, 1176, 1219, 1355, 2204, 3077], '7790-7799Abstract': [784, 2205], '(48)': [792, 1011, 1185, 1228, 1364, 2213, 3086], 'Furthermore,': [795, 1637], 'highly': [798, 1019], 'line': [804, 3406, 3960], 'gene': [809, 1330, 3330], 'reduced': [810, 1054, 1825], 'diminished': [818], '(11Suzuki': [821, 2910, 2990], 'Takei': [831, 988, 1162, 1205, 1341, 2920, 3000, 3063], 'Saga': [833, 990, 1164, 1207, 1343, 2922, 3002, 3065], 'Itoh': [837, 994, 1168, 1211, 1347, 2926, 3006, 3069], 'Int.': [841, 2930, 3010, 3286], 'Cancer.': [843, 1094, 2932, 3012, 3288], '2003;': [844, 1001, 1095, 1175, 1218, 1354, 2933, 3013, 3076], '104:': [845, 2934, 3014], '289-302Crossref': [846, 2935, 3015], '(57)': [849, 2938, 3018], 'Current': [852], 'investigations': [853], 'focused': [855], 'understanding': [857], 'mechanism(s)': [860], 'which': [862, 1277, 1609, 1932, 1940, 2220], 'down-regulates': [864], 'vivo': [874, 1712, 3173], 'controls': [876], '(12Kobayashi': [884], 'Sun': [888, 2602, 2816], 'G.W.': [889, 2603, 2817], 'Fujie': [890, 924, 952, 2604, 2818], '275:': [902, 1419, 1447, 1625, 1664, 1692], '21185-21191Abstract': [903], '(40)': [911], '13Hirashima': [914], '13650-13656Abstract': [937], '(27)': [945, 2628, 2842], '14Suzuki': [948], '277:': [966], '8022-8032Abstract': [967], '(29)': [975], '15Suzuki': [978], '14640-14646Abstract': [1003, 1177, 1220, 1356, 3078], 'also': [1015, 1110], 'found': [1016], 'metastatic,': [1020], 'transformed': [1021], 'synthesize': [1023], 'lower': [1024], 'non-tumorigenic': [1030], '2Y.': [1032], 'Kobayashi,': [1036], 'unpublished': [1037], 'observations.': [1038], 'addition,': [1040], 'showed': [1042], 'there': [1044], 'direct': [1047], 'correlation': [1048], 'between': [1049, 2737], 'overexpression': [1051], 'metastatic': [1055, 3174], 'potential': [1056, 1071], 'primary': [1058, 3677, 4000], 'biopsies': [1060], 'lines,': [1064], 'reflected': [1066], 'their': [1068], 'through': [1074, 2500], 'Matrigel': [1076], 'barrier': [1077], '(16Tanaka': [1078], 'Yamakawa': [1088], 'Morishita': [1090], '98:': [1096], '424-430Crossref': [1097], '(22)': [1100], 'this': [1104, 1744, 2976], 'invading': [1105], 'model': [1106, 2870], 'system,': [1107], 'part': [1115], 'negative': [1118], 'program,': [1120], 'evaluated': [1122], 'uPA/uPAR': [1126], 'synthesis.': [1127], 'For': [1128, 2216, 2661, 3501, 3565], 'identifying': [1129], 'full': [1131], 'repertoire': [1132], 'bikunin-regulated': [1134, 1191], 'genes,': [1135, 1237], 'recently': [1137], 'conducted': [1138], 'cDNA': [1140, 2457, 2540, 2549, 2597, 2633, 2705, 2773, 3181, 3188, 3304, 3320], 'microarray': [1141], 'hybridization': [1142, 2460], 'screening,': [1143], 'using': [1144, 2236, 2450, 2515, 2867, 3255, 3616, 3744, 4078, 4304, 4337], 'from': [1146, 1865, 1876, 1968, 2018, 2037, 2048, 2064, 2078, 2085, 2108, 2118, 2124, 2136, 2144, 2696, 3385, 3750, 3791, 3957], 'bikunin-treated': [1147], 'or': [1148, 1728, 2023, 2295, 2342, 2512, 2982, 3252, 3536, 3655, 3931, 3933, 4068, 4283], 'bikunin-transfected': [1149], '(15Suzuki': [1152, 1195, 1331, 3053], 'number': [1189], 'genes': [1192, 1297], 'identified': [1194, 1233, 1649], 'screen': [1232], 'suppression': [1234, 1261], 'such': [1238, 1723, 1734], 'CDC-like': [1240], 'kinase,': [1241, 1254], 'LIM': [1242], 'domain': [1243, 1246, 1505], 'binding,': [1244], 'Ets': [1245], 'transcription': [1247, 3384], 'factor,': [1248, 1485], 'Rho': [1249], 'GTPase-activating': [1250], 'protein,': [1251, 1256, 1472, 2968], 'tyrosine': [1252, 1613], 'phosphorylation-regulated': [1253], 'hyaluronan-binding': [1255], '(also': [1258], 'tumorigenicity': [1263], '14,': [1264], 'epithin,': [1265], 'membrane-type': [1267], 'protease-1),': [1269], 'pregnancy-associated': [1270], 'plasma': [1271, 3781], 'protein-A,': [1272], '3-kinase': [1275], '(PI3K),': [1276], 'been': [1279], 'implicated': [1280], 'previously': [1281, 2466, 2909], 'enhancing': [1283], 'promotion.': [1285], 'These': [1286], 'results': [1287], 'alters': [1291], 'pattern': [1294], 'leading': [1301], 'block': [1304], 'invasion.': [1307], 'Interestingly,': [1308], 'Northern': [1309, 2453], 'blot': [1310, 2459, 2957], 'analysis': [1311, 4075], 'confirmed': [1312, 2951], 'markedly': [1316], 'down-regulated': [1317], 'bikunin.': [1319], 'Therefore,': [1320], 'considered': [1323], 'important': [1327, 1400, 1793], 'target': [1329], 'type': [1369], 'II': [1370], 'membrane': [1371, 2116, 3970, 4301], '(17Hooper': [1374], 'J.D.': [1375], 'Clements': [1376], 'J.A.': [1377, 2684], 'Quigley': [1378], 'J.P.': [1379, 3129], 'Antalis': [1380], 'T.M.': [1381], '857-860Abstract': [1387], '(323)': [1395], 'Scholar),': [1397, 2734], 'may': [1398, 1791, 1829], 'play': [1399, 1792], '(18Lee': [1409, 1615, 1654], 'S.L.': [1410, 1616, 1655, 3210], 'Dickson': [1411, 1514, 1617, 1656, 1757, 1992], 'R.B.': [1412, 1515, 1618, 1657, 1758, 1993], 'Lin': [1413, 1619, 1658, 1759], 'C.Y.': [1414, 1507, 1620, 1659, 1760, 1985], '36720-36725Abstract': [1420, 1626, 1665], '(356)': [1428, 1634, 1673], '19Takeuchi': [1431, 1676], 'Harris': [1433, 1678], 'J.L.': [1434, 1679], 'Huang': [1435, 1680], 'W.': [1436, 1681], 'Yan': [1437, 1682], 'K.W.': [1438, 1683], 'Coughlin': [1439, 1684], 'S.R.': [1440, 1685, 2571, 3212], 'Craik': [1441, 1536, 1686], 'C.S.': [1442, 1537, 1687], '26333-26342Abstract': [1448, 1693], '(392)': [1456, 1701], 'It': [1459], 'has': [1460], 'multidomain': [1462], 'structure,': [1463], 'containing': [1464, 2365, 2505, 2700, 3156, 3315, 3376, 3519, 3910, 3986, 4133, 4161, 4177], 'putative': [1466, 1710], 'transmembrane': [1468], 'region,': [1469], 'sperm': [1471], 'enterokinase,': [1473], 'agrin': [1475], '(SEA)': [1476], 'domain,': [1477], 'two': [1478, 3887, 4189], 'complement': [1479], 'subcomponents': [1480], 'C1r/C1s,': [1481], 'urchin': [1482], 'embryonic': [1483], 'bone': [1487], 'morphogenic': [1488], '(CUB)': [1490], 'domains,': [1491], 'four': [1492], 'density': [1494, 4319], 'lipoprotein': [1495], 'class': [1497], 'repeats,': [1499], 'carboxyl-terminal': [1502], '(20Lin': [1506], 'Anders': [1508, 1986], 'Johnson': [1510, 1755, 1988], 'Sang': [1512, 1990], 'Q.A.': [1513, 1991], '1999;': [1519, 1545, 1590, 1997, 3274, 3346, 3489], '274:': [1520, 1998], '18231-18236Abstract': [1521], '(192)': [1529], '21Takeuchi': [1532], 'Shuman': [1534], 'M.A.': [1535], 'Proc.': [1538, 3134], 'Natl.': [1539, 3135], 'Acad.': [1540, 3136], 'U.': [1542, 3138], 'A.': [1544, 1766, 1768, 2710, 3140, 3285], '96:': [1546], '11054-11061Crossref': [1547], '(232)': [1550, 2007], '22Tanimoto': [1553], 'Underwood': [1555], 'L.J.': [1556], 'Wang': [1557], 'Shigemasa': [1559], 'Parmley': [1561], 'T.H.': [1562], "O'Brien": [1563], '22:': [1568], '104-114Crossref': [1569], '(76)': [1572], '23Kim': [1575], 'M.G.': [1576, 2567], 'Chen': [1577], 'C.': [1578, 1586, 2569, 2575, 2720, 3281], 'Lyu': [1579], 'M.S.': [1580], 'Cho': [1581], 'E.G.': [1582, 2565], 'Park': [1583, 2578], 'D.': [1584, 2579, 2613, 2827, 3260, 3264, 3332, 3336, 3475, 3479, 3815], 'Kozak': [1585], 'Schwartz': [1587, 2576, 3816], 'R.H.': [1588, 2577], 'Immunogenetics.': [1589], '49:': [1591], '420-428Crossref': [1592], '(125)': [1595], 'Matriptase': [1598, 3022], 'convert': [1600], 'hepatocyte': [1601], 'factor/scatter': [1603], 'factor': [1604], 'its': [1606, 1898, 1908, 3771, 3850], 'form,': [1608], 'c-Met': [1612], 'phosphorylation': [1614], 'protease-activated': [1638], '2': [1640, 2380, 2389, 3547, 3595, 3673, 3937, 4215], '(PAR2)': [1641], 'single-chain': [1645, 1957], '(pro-uPA)': [1647], 'substrates': [1651, 1713], 'identification': [1705], 'these': [1707], 'molecules': [1708], 'suggests': [1714], 'regulates': [1717], 'functions': [1719], 'mediated': [1720], 'PAR2,': [1722], 'inflammatory': [1726], 'response': [1727], 'adhesion,': [1730], 'associated': [1747], 'more': [1750], 'phenotype': [1752], '(24Oberst': [1753], 'M.D.': [1754, 1756], 'Singh': [1761], 'Stewart': [1763], 'Williams': [1765], 'al-Nafussi': [1767], 'Smyth': [1769], 'J.F.': [1770], 'Gabra': [1771], 'Sellar': [1773], 'G.C.': [1774, 3266, 3338, 3481], 'Clin.': [1775, 3233, 3271, 3343, 3486], '8:': [1779], '1101-1107PubMed': [1780], 'studies': [1784], 'suggest': [1787], 'well': [1799], 'There': [1805], 'no': [1807], 'indicating': [1809], 'surface': [1818], 'To': [1822], 'clarify': [1823], 'how': [1824], 'confer': [1830], 'repressed': [1831], 'invasiveness,': [1832], 'transiently': [1834], 'transfected': [1835, 1848, 2896, 3245, 3309], 'antisense': [1839, 3043, 3197, 3247], '(AS)-matriptase,': [1840], 'clones': [1849, 2275, 2942, 3165], 'those': [1851], 'parental': [1853, 2979], 'stable': [1857], 'transfectants.': [1859], 'Materials—Purified': [1860], 'obtained': [1864, 1967, 2036, 2063, 2107, 4264], 'Mochida': [1866], 'Pharmaceutical': [1867], 'Co.': [1868], '(Gotenba,': [1869], 'Japan).': [1870, 2026, 2067], 'LipofectAMINE': [1871], 'Plus': [1872], 'reagent': [1873, 2239, 3093], 'purchased': [1875, 2017, 2077, 2084, 2123, 2135, 2143], 'Invitrogen.': [1877, 2079], 'antibodies': [1879, 2015, 3654, 3658, 3929, 4001], 'against': [1880, 1982], '(3689': [1882, 3679], '(recognizes': [1883, 1902], 'B-chain)': [1885], '3471': [1887], '(reacts': [1888], 'A-chain;': [1891], 'interferes': [1892], 'receptor)),': [1899], 'PAI-1': [1900, 1906, 1912, 2704], '(379': [1901], 'all': [1903, 2217, 3720, 3766], 'complexes': [1909, 3105], 'neutralizes': [1911], 'inhibition)),': [1913], '(3932': [1915], '(equally': [1916], 'reactive': [1917], 'occupied': [1919], 'unoccupied': [1921], 'uPAR)': [1922], '3936': [1924], '(interferes': [1925], 'binding)),': [1928], '(3641,': [1931], 'does': [1933], 'not': [1934], 'affect': [1935], 'activity,': [1937], '3644,': [1939], 'competitively': [1941], 'activity),': [1944], 'chromogenic': [1946], 'substrate': [1947], 'urokinase,': [1949], 'Spectrozyme': [1950, 3792, 3913], 'UK': [1951, 3914], '(carbobenzoxy-l-glutamyl-(α-t-butoxyl)-glycyl-arginine-p-nitroanilide': [1952], 'diacetate': [1953], 'salt),': [1954], 'Glu-plasminogen,': [1955], 'plasmin,': [1956], '(pro-uPA),': [1959], 'weight': [1963, 3421], 'Dr.': [1969], 'Hart': [1971], '(American': [1972], 'Diagnostics,': [1973], 'Greenwich,': [1974], 'CT).': [1975], 'monoclonal': [1977, 4006], 'antibody,': [1978], 'M32,': [1979], 'directed': [1981], '(25Lin': [1984], '18237-18242Abstract': [1999], 'Anti-human': [2010], 'cathepsins': [2011], 'B': [2012, 4017], 'L': [2014, 4022], 'Oncogene': [2019], 'Science': [2020], '(Cambridge,': [2021, 2050, 2087], 'MA)': [2022, 2051, 2088], 'CosmoBio': [2024], '(Tokyo,': [2025], 'Boyden-type': [2027], 'chambers': [2030], '(BioCoat': [2031], 'Matrigel™': [2032], 'chambers)': [2034], 'Collaborative': [2038], 'Biomedical': [2039], '(Franklin': [2040], 'Lakes,': [2041], 'NJ).': [2042], 'Ultrapure': [2043], 'natural': [2044], 'Genzyme': [2049], 'R&D': [2053], 'Systems': [2054], '(Minneapolis,': [2055], 'MN).': [2056], '(Balb-c,': [2060], 'nu/nu)': [2061], 'SLC': [2065], '(Hamamatsu,': [2066], 'Culture': [2068], 'media,': [2069], 'penicillin,': [2070], 'streptomycin,': [2071], 'fetal': [2073, 2174, 3158], 'bovine': [2074, 2175, 3159], 'Tissue': [2080], 'culture': [2081, 3865], 'plastics': [2082], 'Costar/Corning': [2086], 'Falcon': [2090], '(BD': [2091, 3709], 'Biosciences).': [2092, 3710], 'albumin': [2095], '(BSA),': [2096], 'Tris': [2097, 4157], 'base,': [2098], 'dithiothreitol,': [2099, 2391], 'phenylmethylsulfonyl': [2100, 2399], 'fluoride,': [2101], 'ammonium': [2103], 'persulfate': [2104], 'commercially': [2106], 'Sigma.': [2109], 'Acrylamide,': [2110], 'bisacrylamide,': [2111], 'difluoride': [2114], '(PVDF)': [2115], 'Bio-Rad.': [2119], 'X-ray': [2120], 'film': [2121, 2857, 4070], 'Eastman': [2125], 'Kodak.': [2126], 'enhanced': [2128, 4050], 'chemiluminescence': [2129, 4051], '(ECL)': [2130], 'carrier-free': [2132], 'Na125I': [2133, 3433], 'Amersham': [2137], 'Biosciences.': [2138], 'MTT': [2139, 4307, 4341], 'assay': [2140, 3764, 4342], 'kit': [2141, 3749, 4343], 'Chemicon': [2145], 'International': [2146], 'Inc.,': [2147], 'Temecula,': [2148], 'CA.': [2149], 'All': [2150, 2426], 'other': [2151], 'chemicals': [2152], 'analytical': [2154], 'grade.': [2155], 'Culture—The': [2157], 'line,': [2161], 'HRA,': [2162], 'grown': [2164, 3861], "Dulbecco's": [2166, 2288], 'modified': [2167, 2289, 3516], "Eagle's": [2168, 2290, 3517], 'medium': [2169, 2291, 2306, 3115, 3155, 3518, 3738, 4090, 4327], '(Sigma)': [2170], 'supplemented': [2171], '10%': [2173, 3157, 4102], 'serum,': [2176], 'penicillin': [2177], '(100': [2178, 2182], 'units/ml),': [2179], 'streptomycin': [2181], 'μg/ml)': [2183], 'a5%CO2': [2185], 'atmosphere': [2186], 'constant': [2188], 'humidity': [2189], '(10Kobayashi': [2190], 'experiments': [2218], 'added,': [2223], 'incubated': [2226, 2285, 3095, 3527, 3651, 3872, 3892, 3907, 4130, 4149, 4213, 4227], 'serum-free': [2229, 2287], 'medium.': [2230, 4332], 'Total': [2231], 'RNA': [2232, 2493, 2784], 'isolations': [2233], 'done': [2235], 'Trizol': [2238], '(Invitrogen).': [2240], 'concentrations': [2243, 3530, 3585], 'supernatants': [2246, 2327, 4262, 4274], 'extracts': [2249, 2414], 'measured': [2251, 3734, 3765, 3794, 4336], 'Bio-Rad': [2254, 2869], 'assay.': [2256, 4072], 'Preparation': [2257], 'Conditioned': [2259], 'Medium': [2260], 'Lysate—For': [2263], 'preparation': [2265], 'conditioned': [2267, 2305, 4089], 'medium,': [2268], 'subconfluent': [2269], 'cultures': [2270, 3858], 'washed': [2277, 2350, 2850, 3112, 3555, 3627, 3666, 3868, 3886, 3904, 4173, 4222], 'three': [2278, 3667], 'times': [2279, 2348, 3668], 'saline': [2282, 3985], '(PBS)': [2283], 'presence': [2294, 3436, 3535, 3921, 4207], 'absence': [2296, 3537, 3924], '10': [2298, 2383, 3438, 3760, 3894, 3926], 'ng/ml': [2299], '24': [2302], 'h.': [2303, 3663, 4045], 'collected,': [2308], 'centrifuged': [2309, 2417, 3952], 'remove': [2311, 2423], 'debris,': [2313], 'filtered,': [2314], 'lyophilized,': [2315], 'concentrated,': [2316, 4276], 'stored': [2318, 2429], 'at': [2319, 2401, 2418, 2430, 2858, 3099, 3549, 3759, 3803, 3900, 3939, 3980, 4003, 4038, 4113, 4141, 4151, 4217, 4231, 4317], '–80': [2320, 2431], '°C': [2321, 2403, 2432, 3902, 4153, 4233], 'until': [2322, 2433], 'needed.': [2323], 'general,': [2325], 'concentrated': [2328, 4088], '10-fold': [2329], 'zymography': [2333, 4067], 'Western': [2335, 2956, 3947], 'blot.': [2336], 'monolayers': [2339], 'treated': [2340, 2438, 3579, 3637, 4248], 'various': [2344], 'agents': [2345], 'PBS.': [2352], '1': [2353, 2392, 2397, 2961, 2971, 3430, 3662, 3698, 3916, 3978, 4044], '×': [2354, 2420, 2535, 3508, 3572, 4195], '106': [2355], 'lysed': [2358], '750': [2360], 'μl': [2361, 3674, 3688], 'lysis': [2363], 'buffer': [2364, 3514, 3562, 3577, 3878, 4096, 4132, 4158, 4281], '20': [2366, 3989], 'mm': [2367, 2372, 2375, 2378, 2381, 2384, 2390, 2393, 2398, 4098, 4156, 4163, 4251], 'Tris-HCl': [2368, 4099], '(pH': [2369, 3448, 3879, 4100, 4159, 4185], '7.5),': [2370, 3449], '12.5': [2371], '2-glycerophosphate,': [2373], '150': [2374], 'NaCl,': [2376, 4256], '1.5': [2377], 'MgCl2,': [2379], 'EGTA,': [2382], 'NaF,': [2385], '0.5%': [2386], 'Triton': [2387, 4135], 'X-100,': [2388], 'sodium': [2394, 3446, 3456, 3524], 'vanadate,': [2395], 'fluoride': [2400], '4': [2402, 3150, 3550, 3901, 4004, 4218], '15': [2405, 3097, 4162], 'min': [2406, 3098, 3875, 4112, 4140, 4230], 'scraped': [2408], 'rubber': [2411], 'policeman.': [2412], 'then': [2416, 3107, 3906, 4119, 4212, 4226, 4247, 4287], '3,000': [2419], 'g': [2421], 'debris.': [2425], 'samples': [2427], 'use.': [2434], 'parallel,': [2436], 'same': [2441], 'condition': [2442], 'different': [2444], 'dishes': [2445], 'harvested': [2447, 3625], 'counted': [2449], 'hemocytometer.': [2452], 'Blot': [2454, 3948], 'Hybridization': [2455, 2520], 'Probes—Northern': [2458], 'carried': [2462, 2522, 4354], 'out': [2463, 2523, 4355], 'described': [2465, 2908, 3177, 3258, 3807, 4361], '(9Kobayashi': [2467, 2634, 2789], 'Samples': [2490], 'total': [2492], '(10': [2494], 'μg)': [2495, 3956], 'separated': [2497, 4293], 'electrophoresis': [2499, 4122, 4279], 'denaturing': [2501], '1.2%': [2502], 'agarose': [2503], 'gels': [2504, 4128], '1%': [2506], 'formaldehyde': [2507], 'transferred': [2509, 3966, 4298], 'onto': [2510, 2786], 'nylon': [2511], 'nitrocellulose': [2513], 'membranes': [2514, 2848], 'standard': [2516, 2902], 'biological': [2518], 'techniques.': [2519], '[α-32P]dCTP': [2525], 'random': [2527], 'oligonucleotide': [2528], 'priming': [2529], 'activities': [2532, 3496, 4061], '0.4–0.9': [2534], '109': [2536], 'cpm/μg.': [2537], 'following': [2539, 3999, 4324], 'sequences': [2541, 3044], 'probes:': [2545], 'full-length': [2547, 3318], '(pcDNA3/matriptase)': [2550], 'ligated': [2551], 'pcDNA3': [2554], 'vector': [2555, 2884, 2890, 3206, 3250], '(Invitrogen)': [2556], 'under': [2557], 'cytomegalovirus': [2562], 'promoter': [2563], '(26Cho': [2564], 'Kim': [2566, 2568, 2570], 'Seong': [2572], 'I.S.': [2573], 'Chung': [2574], '44581-44589Abstract': [2585], '(74)': [2593], '(27Kobayashi': [2598], 'Shibata': [2606, 2820], 'Tamotsu': [2608, 2822], 'Miura': [2610, 2824], 'Sugino': [2612, 2826], 'Kondo': [2616, 2830], '1998;': [2623, 2837, 3289], '1383:': [2624, 2838], '253-268Crossref': [2625, 2839], 'prepared': [2658], 'described.': [2660], 'pSP64-hPAI-1,': [2662], '1.4-kbp': [2664], 'EcoRI-BglII': [2665], '(position': [2667], '54–1480': [2668], '(28Pannekoek': [2669], 'Veerman': [2671], 'Lambers': [2673], 'Diergaarde': [2675], 'P.': [2676], 'Verweij': [2677], 'C.L.': [2678], 'van': [2679, 2682], 'Zonneveld': [2680], 'A.J.': [2681], 'Mourik': [2683], 'EMBO': [2685], '1986;': [2687, 2727], '5:': [2688], '2539-2544Crossref': [2689], '(261)': [2692], 'Scholar))': [2694], 'isolated': [2695], 'pPAI1-C1,': [2697], 'plasmid': [2699, 3313, 3324, 3370, 3398], '2.2-kbp': [2702], 'insert': [2706], '(29Andreasen': [2707], 'Riccio': [2709], 'Welinder': [2711], 'K.G.': [2712], 'Douglas': [2713], 'Sartorio': [2715], 'Nielsen': [2717], 'L.S.': [2718], 'Oppenheimer': [2719], 'Blasi': [2721], 'F.': [2722, 3268, 3340, 3483], 'FEBS': [2725], 'Lett.': [2726], '209:': [2728], '213-218Crossref': [2729], '(170)': [2732], 'subcloned': [2736], 'BamHI': [2739], 'EcoRI': [2741, 3186], 'sites': [2742], 'pSP64': [2744], '(30Melton': [2745], 'D.A.': [2746], 'Krieg': [2747], 'Rebagliati': [2749], 'M.R.': [2750, 2756], 'Maniatis': [2751], 'Zinn': [2753], 'Green': [2755], 'Nucleic': [2757], 'Acids': [2758], '1984;': [2760], '12:': [2761], '7035-7056Crossref': [2762], '(4060)': [2765], 'Filters': [2768, 2861], 'reprobed': [2770], 'dehydrogenase': [2776], '(GAPDH)': [2777], 'correct': [2779], 'amount': [2782, 3730], 'loaded': [2785], 'filters': [2788], '27Kobayashi': [2812], 'After': [2845, 3149, 3546, 3594, 4126], 'hybridization,': [2846], 'exposed': [2852, 4055], 'Kodak': [2854], 'BioMax': [2855], 'MS-1': [2856], '–70': [2859], '°C.': [2860, 4115, 4219], 'quantitated': [2863, 3606], 'scanning': [2865], 'densitometry': [2866], '620Video': [2871], 'Densitometer': [2872], 'one-dimensional': [2874], 'Analyst': [2875], 'software': [2876], 'package': [2877], 'Macintosh.': [2879], 'Transfection—The': [2881, 3305], 'pCMV-bikunin-IRES-bsr': [2885], '(bik+)': [2886], 'pCMV-luciferase-IRES-bsr': [2891], 'encoding': [2892, 3326], 'luciferase': [2893], '(luc+)': [2894], 'calcium': [2903], 'phosphate': [2904, 3447], 'precipitation': [2905], 'method': [2906], 'Bik+': [2941, 2959], '(clones': [2943], '1–5)': [2944], 'inducible': [2946], 'immunocytochemical': [2953], 'staining': [2954], 'analysis.': [2958], 'clone': [2960, 2970], 'produces': [2962], 'highest': [2964], 'concentration': [2965], 'mainly': [2973], 'throughout': [2975], 'Uninduced': [2978], 'Luc+': [2983], 'Oligodeoxynucleotides': [3023], 'Transfection—': [3026], '18-base': [3028], 'phosphorothioate': [3029], 'oligodeoxynucleotides,': [3030], 'corresponding': [3031], 'mRNA,': [3036], 'synthesized': [3038], 'consisted': [3040], '5′-AGC': [3046], 'TGC': [3047], 'TCA': [3048], 'TCC': [3049], 'TAG': [3050], 'GCA-3′': [3051], '(AS-matriptase)': [3052], 'Oligonucleotides': [3089], 'mixed': [3090, 4092], 'Lipofectin': [3092], 'room': [3100, 3981, 4142], 'temperature.': [3101], 'Thereafter,': [3102], 'oligonucleotides-liposome': [3104], 'twice': [3113, 3558, 3869, 4174, 4245], '(31Felgner': [3116], 'P.L.': [3117], 'Gadek': [3118], 'T.R.': [3119], 'Holm': [3120], 'Roman': [3122], 'Chan': [3124], 'H.W.': [3125], 'Wenz': [3126], 'Northrop': [3128], 'Ringold': [3130], 'G.M.': [3131], 'Danielsen': [3132], '1987;': [3141], '84:': [3142], '7413-7417Crossref': [3143], '(4387)': [3146], 'h,': [3151, 3596], 'fresh': [3152], 'normal': [3153], 'added.': [3162], 'AS-matriptase': [3164], 'below.': [3178], 'Transfection—A': [3182], '1020-bp': [3183], 'PstI': [3184], 'digest': [3187], 'blunt-ended': [3193], 'cloned': [3195], 'orientation': [3198], 'HindIII': [3201], 'cut': [3202], 'phβAPr-1-neo': [3203], 'eukaryotic': [3204], '(32Mohanam': [3207], 'Jasti': [3209], 'Kondraganti': [3211], 'Chandrasekar': [3213], 'Kin': [3215], 'Fuller': [3217], 'G.N.': [3218], 'Lakka': [3219], 'S.S.': [3220], 'Kyritsis': [3221], 'A.P.': [3222], 'Dinh': [3223], 'D.H.': [3224], 'Olivero': [3225], 'W.C.': [3226], 'Gujrati': [3227], 'Yung': [3229], 'W.K.A.': [3230], 'Rao': [3231], 'J.S.': [3232], '7:': [3237], '2519-2526PubMed': [3238], 'cDNA-containing': [3249], '(AS-uPA)': [3251], 'empty': [3253], 'vector,': [3254], 'Lipofectin,': [3256], '(33Morrissey': [3259, 3331, 3474], "O'Connell": [3261, 3333, 3476], 'Lynch': [3263, 3335, 3478], "O'Sullivan": [3265, 3337, 3480], 'Shanahan': [3267, 3339, 3482], 'Collins': [3269, 3341, 3484], 'J.K.': [3270, 3342, 3485], 'Exp.': [3272, 3344, 3487], 'Metastasis.': [3273, 3345, 3361, 3488], '17:': [3275, 3347, 3490], '77-85Crossref': [3276, 3348, 3491], '34Haeckel': [3280], 'Krueger': [3282], 'Roessner': [3284], '77:': [3290], '153-160Crossref': [3291], '(26)': [3294], 'according': [3298, 4344], "manufacturer's": [3301, 4347], 'instructions.': [3302], 'pcUKLTR6,': [3314], 'construct,': [3321], 'pSVneo,': [3325], 'neomycin': [3328], 'resistance': [3329], '35Jarrard': [3352], 'D.F.': [3353], 'N.M.': [3355], 'Patai': [3356], 'Rukstalis': [3358], 'D.B.': [3359, 3819], 'Invasion': [3360, 4350], '15:': [3363], '34-45PubMed': [3364], 'contains': [3371], '1300-bp': [3373], 'SmaI-SmaI': [3374], 'enhancer-promoter': [3378], 'element': [3379], 'start': [3382], 'Harvey': [3387], 'sarcoma': [3388], 'virus': [3389], '5′-long': [3390], 'terminal': [3391], 'repeat.': [3392], 'separate': [3394], 'pSVneo': [3399], 'performed': [3401, 4077], 'serve': [3408], 'control.': [3411], 'Surface': [3413], 'Receptor': [3414], 'Binding—Pro-uPA': [3415], 'diisopropylfluorophosphate': [3417], '(DFP)-treated': [3418], '(HMW)-uPA': [3422], '(150': [3423], 'μg/100': [3424], 'μl)': [3425, 4085], 'each': [3427, 3958], 'radiolabeled': [3428], 'mCi': [3431], 'μg': [3439, 3454], 'chloramine': [3441], 'T': [3442], '0.15': [3444], 'm': [3445, 4255], 'after': [3451], 'adding': [3452], '83': [3453], 'metabisulfite': [3457], 'purified': [3459], 'PD-10': [3462], 'column': [3463], '(Amersham': [3464, 4052], 'Biosciences)': [3465, 4053], 'equilibrated': [3466], 'eluted': [3468], '0.2%': [3470, 3523], 'BSA': [3471, 3521, 4178], 'PBS': [3473, 3909, 4176, 4244], 'Specific': [3495, 3612], 'typically': [3498], '3.0–4.1': [3499], 'μCi/μg.': [3500], 'studies,': [3503], '200-μl': [3504, 3568], 'aliquots': [3505, 3569], '5': [3507, 3571, 3874, 4209], '105': [3509, 3573], 'acid-treated': [3510], "(Dulbecco's": [3515], '0.1%': [3520, 3987], 'plus': [3522, 4009], 'azide)': [3525], 'increasing': [3529], '125I-DFP-uPA': [3532], 'excess': [3540], '(up': [3541], '1000-fold)': [3543], 'HMW-uPA.': [3545], 'h': [3548, 3699, 3899, 3938, 3979, 4216], '°C,': [3551, 3941], 'centrifugation': [3557, 4266], 'cold': [3560, 4243], 'counted.': [3564], 'displacement': [3566], 'assays,': [3567], '1.0': [3581, 4194], 'nm125I-DFP-uPA': [3582], 'differing': [3584], 'competitors': [3587], '(HMW-uPA,': [3588], '(ATF)).': [3593], 'washed,': [3600], 'bound': [3603], 'radiolabel': [3604], 'dissolving': [3608], 'NaOH.': [3611], 'quantified': [3615], 'multiwell': [3618], 'γ-counter.': [3619], 'Flow': [3620], 'Cytometric': [3621], 'Analysis—Cultured': [3622], 'buffer.': [3630], 'Because': [3631], 'trypsin-sensitive,': [3634], 'hyaluronidase': [3639], 'further': [3643], 'experiments.': [3644, 3721], 'single': [3646], 'suspension': [3648], '(106/ml)': [3649], 'affinity-purified': [3653], 'isotype': [3656], 'ice': [3660], 'Cells': [3664, 3703, 4220], 'buffer,': [3671], 'antibody': [3678, 3693, 4014, 4018, 4023, 4036], '(uPA),': [3680], '379': [3681], '(PAI-1),': [3682], '3932': [3684], '(uPAR))': [3685], '3': [3687, 3898, 4290], 'fluorescein': [3690], 'isothiocyanate-conjugated': [3691], 'second': [3692], '(Dako)': [3694, 4037], 'ice,': [3701], 'respectively.': [3702], 'analyzed': [3705, 3716, 3962, 4064], 'FACScan': [3708], 'At': [3711], 'least': [3712], '10,000': [3713], 'per': [3717], 'sample': [3718, 4117, 4280], 'Quantitation': [3722], 'Level,': [3725], 'Enzyme-linked': [3726], 'Immunosorbent': [3727], 'Assay—': [3728], 'cell-conditioned': [3737], 'lysate': [3743], 'Imubind': [3746], 'ELISA': [3748], 'American': [3751], 'Diagnostics': [3752], 'Inc.': [3753], 'Lower': [3754], 'detection': [3755], 'set': [3758], 'pg/ml.': [3761], 'complexes.': [3772], 'Measurement': [3773], 'Amidolytic': [3776], 'Activity—The': [3777], 'amidolytic': [3778, 3841], 'activity': [3779, 3842], 'monitored': [3785], 'release': [3788], 'p-nitroaniline': [3790], 'UK,': [3793], 'rate': [3797], 'change': [3799], 'light': [3801], 'absorbance': [3802], '405': [3804], 'nm': [3805, 3895], '(36Higazi': [3808], 'A.A.': [3809], 'Cohen': [3810], 'R.L.': [3811], 'Henkin': [3812], 'Kniss': [3814], 'B.S.': [3817], 'Cines': [3818], '270:': [3824], '17375-17380Abstract': [3825], '(89)': [3833], 'minor': [3838], 'modification.': [3839], 'induced': [3843], 'determined': [3853], 'surfaces.': [3856], 'Confluent': [3857], '96-well': [3863, 4315], 'plates': [3866, 4316], 'glycine': [3877, 4252], '3),': [3880], 'elute': [3882], 'endogenous': [3883], 'additional': [3888], 'times.': [3889], 'scuPA': [3896], '300': [3911], 'μm': [3912, 3917], 'Glu-plasminogen': [3918], 'μg/ml': [3927], 'anti-plasmin': [3928], '(3641': [3930], '3644)': [3932], 'nonimmune': [3934], 'IgG': [3935], '37': [3940, 4152, 4232], 'A405': [3944], 'determined.': [3946], 'Analysis—Conditioned': [3949], 'media': [3950], 'lysates': [3954], '(50': [3955], 'SDS-PAGE': [3964, 4073, 4295], 'PVDF': [3969, 4300], 'semi-dry': [3972], 'transfer.': [3973], 'Membranes': [3974], 'blocked': [3976], 'temperature': [3982], 'Tris-buffered': [3984], 'Tween': [3988], '(TBST)': [3990], '2%': [3992], 'BSA.': [3993], 'Blots': [3994], 'probed': [3996], 'overnight': [4002, 4150], '°C:': [4005], 'anti-uPA': [4007], '(3471': [4008], '3689)': [4010], '(each': [4011], '1:500),': [4012], 'anti-matriptase': [4013], '(1:2000),': [4015], 'anticathepsin': [4016], '(1:200),': [4019], 'anti-cathepsin': [4021], '(1:500).': [4024], 'followed': [4027, 4187], 'incubation': [4029], 'appropriate': [4032], 'horseradish': [4033], 'peroxidase-conjugated': [4034], 'secondary': [4035], 'dilution': [4040], '1:50,000': [4042], 'Detection': [4046], 'film.': [4057], 'Zymographic': [4058], 'Analysis—Plasminogen': [4059], 'qualitatively': [4063], 'fibrin': [4066], 'casein': [4069], 'fibrinolysis': [4071], 'zymographic': [4074], 'copolymerized': [4079], 'plasminogen-rich': [4080], 'fibrinogen.': [4081], 'Equal': [4082], 'volumes': [4083], '(20': [4084], '10×': [4087], '4×': [4094], 'nonreducing': [4095], '(200': [4097], '7.4),': [4101, 4186], 'SDS,': [4103], '4%': [4104], 'sucrose,': [4105], '0.4%': [4107], 'Coomassie': [4108], 'Blue)': [4109], '30': [4111, 4139], '25': [4114], 'Each': [4116], 'subjected': [4120], 'polyacrylamide': [4124], 'gel.': [4125], 'electrophoresis,': [4127], '2.5%': [4134], 'X-100': [4136], '(twice': [4137], 'temperature),': [4143], 'rinsed': [4144], 'distilled': [4146], 'water,': [4147], '100': [4155], '7.4)': [4160], 'CaCl2.': [4164], 'Cleavage': [4165], 'Pro-uPA—Unstimulated': [4168], 'TGF-β1-stimulated': [4170], '1000': [4180, 4321], 'kallikrein-inactivating': [4181], 'units/ml': [4182], 'Trasylol': [4184], 'washes': [4190], 'PBS/BSA.': [4192, 4235], 'Subsequently,': [4193], '107': [4196], 'resuspended': [4199], '0.5': [4201, 4254], 'ml': [4202], 'PBS/BSA': [4204, 4224], 'nm125I-pro-uPA': [4210], '80': [4229], 'reaction': [4237], 'stopped': [4239], 'washing': [4241], '50': [4250], 'HCl,': [4253], 'pH': [4257, 4271], '3.0': [4258], '(acidic': [4259], 'buffer).': [4260], 'immediately': [4268], 'adjusted': [4269], '7.4.': [4272], 'dissolved': [4277], '2-mercaptoethanol,': [4285], 'boiled': [4288], 'min.': [4291], 'Proteins': [4292], 'electrophoretically': [4297], 'visualized': [4303], 'PhosphorImager.': [4306], 'Assay': [4308], 'Proliferation—Cells': [4311], 'seeded': [4313], 'cells/well.': [4322], 'day,': [4325], 'changed': [4329], 'regular': [4331], 'Viable': [4333], 'quantitative': [4339], 'colorimetric': [4340], 'protocol.': [4348], 'Assay—Chemoinvasion': [4351], 'assays': [4352], 'Boyden': [4358], 'chamber,': [4359], '(8Kobayashi': [4362], '11Suzuk': [4388]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1996196320', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-10T01:14:07.081796', 'created_date': '2016-06-24'}
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