Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70

Name: Work Video:
Duration: 3 min 30 s
Hong-Ying Wang; Yoav Altman; Deyu Fang; Chris Elly; Yang Dai; Yuan Shao; Yun‐Cai Liu
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4382, 4392, 4395, 4399, 4415, 4422, 4438, 4453, 4463, 4473, 4517, 4527, 4532, 4535, 4548, 4557, 4570, 4581, 4594, 4598, 4610, 4614], 'T': [3, 111, 126, 234, 249, 269, 293, 495, 553, 560, 670, 690, 769, 1597, 1708, 2111, 2117, 2148, 2581, 2764, 2818, 2900, 4095, 4331], 'cell': [4, 23, 112, 127, 146, 235, 250, 270, 294, 496, 557, 561, 673, 1051, 1311, 1498, 1598, 1709, 2118, 2615, 4348], 'antigen': [5, 128, 288, 555], 'receptor': [6, 129, 251, 295, 1090, 1111, 1368, 1619], '(TCR)·CD3': [7, 130], 'complex': [8, 131, 248, 339, 587, 598, 658, 1504, 3113, 3668, 4144], 'induces': [9, 132, 419, 1646], 'its': [10, 47, 133, 170, 1638, 1672, 3028, 3233, 3271, 3278, 3891, 3984, 4030, 4038, 4388, 4470], 'ubiquitination.': [11, 134, 1639, 3390, 3542, 3580, 3797, 3835, 3929, 4247], 'However,': [12, 135, 909, 3498, 4112], 'molecular': [14, 137, 911, 1702, 2538, 2642, 4214], 'events': [15, 138, 2539, 4215], 'that': [16, 33, 83, 139, 156, 206, 340, 503, 1293, 1342, 1354, 1365, 1496, 1604, 1610, 1643, 1685, 2469, 2645, 2667, 2805, 2824, 2993, 3005, 3115, 3374, 3566, 3591, 3690, 3723, 3866, 3882, 3969, 4127, 4441, 4482], 'lead': [17, 140], 'to': [18, 21, 65, 141, 144, 188, 291, 494, 664, 679, 748, 754, 760, 828, 996, 1011, 1035, 1045, 1624, 1636, 1649, 1695, 1849, 1873, 1906, 2083, 2088, 2094, 2312, 2381, 2535, 2543, 2551, 2664, 2754, 2790, 2889, 2922, 2925, 3010, 3089, 3095, 3216, 3235, 3267, 3273, 3317, 3387, 3445, 3481, 3483, 3506, 3531, 3558, 3597, 3610, 3649, 3664, 3672, 3675, 3725, 3756, 3806, 3838, 3887, 3942, 3946, 3950, 3977, 4040, 4102, 4136, 4140, 4254, 4276, 4278, 4374, 4409, 4468, 4485, 4542, 4608, 4617], 'ubiquitin': [19, 142, 259, 751], 'conjugation': [20, 143, 753, 1116, 1373, 1648, 1694, 2542, 2663, 2789, 2888, 2921, 3094, 3316, 3444, 3480, 3557, 3805, 3837, 3949, 4101, 4149, 4275, 4408, 4475, 4484, 4566, 4607], 'these': [22, 75, 145, 198, 4243, 4283, 4323], 'surface': [24, 147, 1052, 1312, 1499], 'molecules': [25, 148, 3710], 'have': [26, 149, 508, 1291, 2467, 2822, 3002, 3864, 3967], 'not': [27, 150, 3647], 'been': [28, 151, 765, 1921], 'defined.': [29, 152], 'Here': [30, 153, 1640], 'we': [31, 154, 1641, 2549, 2689, 3068, 3207, 3319, 4065, 4221, 4390], 'report': [32, 155], 'Cbl,': [34, 69, 157, 192, 1119, 1210, 3228], 'a': [35, 103, 158, 226, 336, 390, 510, 661, 666, 834, 921, 926, 949, 998, 1012, 1055, 1087, 1211, 1219, 1224, 1273, 1277, 1351, 1356, 1614, 1654, 1701, 1762, 1787, 1800, 2114, 2570, 2601, 2610, 2638, 2726, 2810, 2926, 3130, 3209, 3256, 3399, 3484, 3939, 3970, 4067, 4223, 4250, 4264, 4279, 4294, 4305, 4618, 4621], 'RING-type': [36, 159, 1615, 2727], 'E3': [37, 160, 958, 1347, 1616, 1632, 2728, 2814, 3201, 3582], 'ubiquitin-protein': [38, 161], 'ligase,': [39, 162], 'promotes': [40, 163], 'ubiquitination': [41, 97, 118, 164, 220, 241, 916, 1109, 1713, 2479, 2760, 2833, 2995, 3238, 3360, 3813, 3963, 4019, 4043, 4062, 4120, 4218, 4310, 4428, 4456, 4587], 'TCRζ': [43, 67, 88, 166, 190, 211, 361, 371, 408, 451, 515, 548, 762, 823, 879, 914, 1605, 1634, 1650, 1669, 1696, 1715, 1777, 1859, 1864, 1876, 2475, 2558, 2566, 2632, 2709, 2769, 2785, 2806, 2832, 2890, 2904, 2994, 3066, 3070, 3096, 3205, 3237, 3359, 3389, 3482, 3508, 3541, 3559, 3579, 3670, 3757, 3796, 3802, 3807, 3812, 3834, 3839, 3928, 3951, 3962, 4018, 4024, 4042, 4103, 4146, 4237, 4246, 4277, 4309, 4338, 4364, 4385, 4410, 4433, 4447, 4467, 4486, 4518, 4572, 4596, 4612], 'chain,': [44, 167, 763, 1651, 1720], 'which': [45, 63, 107, 168, 186, 230, 540, 1652, 1705, 2557, 2792, 3121], 'requires': [46, 169, 1653], 'functional': [48, 171, 1655, 3434], 'variant': [49, 172, 1270, 1661, 2038, 3136, 3396, 3452, 3699, 3727, 3878], 'Src': [50, 173, 264, 433, 459], 'homology': [51, 174, 265, 460], '2': [52, 175, 266, 461, 2267, 2331, 2353, 3104, 3246, 3367], 'domain': [53, 176, 267, 877, 1280, 1364, 1663, 2040, 2056, 3138, 3438, 3454, 3570, 3684, 3701, 3880], 'and': [54, 68, 89, 94, 114, 177, 191, 212, 217, 237, 348, 357, 370, 407, 440, 450, 470, 477, 505, 675, 758, 838, 937, 947, 957, 1005, 1007, 1030, 1104, 1113, 1276, 1288, 1300, 1361, 1600, 1609, 1658, 1724, 1796, 1823, 1836, 1870, 2041, 2053, 2067, 2091, 2141, 2184, 2223, 2242, 2269, 2274, 2285, 2369, 2389, 2417, 2457, 2608, 2613, 2666, 2677, 2770, 2905, 3026, 3100, 3139, 3177, 3187, 3220, 3242, 3262, 3276, 3363, 3379, 3402, 3455, 3464, 3471, 3495, 3571, 3606, 3613, 3671, 3702, 3754, 3811, 3847, 3852, 3860, 3881, 4081, 4180, 4206, 4238, 4314, 4336, 4452, 4556, 4575, 4593, 4613], 'an': [55, 71, 178, 194, 992, 1120, 1268, 1346, 1362, 1591, 1631, 1688, 1804, 1898, 1998, 2072, 2351, 3032, 3375, 3394, 3538, 3654, 3666, 4055, 4132, 4151], 'intact': [56, 179, 3376], 'RING': [57, 180, 1274, 1352, 1656, 2043, 2051, 3015, 3119, 3141, 3249, 3312, 3377, 3400, 3457, 3462, 3525, 3573], 'finger.': [58, 181], 'The': [59, 182, 331, 363, 442, 479, 1016, 1602, 1775, 1887, 1915, 1985, 2530, 2591, 2622, 2697, 2720, 2802, 2935, 3248, 3475, 3562, 3581, 3677, 4012, 4033, 4072, 4123, 4142, 4347, 4355, 4405, 4554], 'tyrosine': [60, 183, 257, 423, 436, 443, 1091, 1283, 1369, 1620, 1847, 1904, 3867, 4230, 4252], 'kinase': [61, 184, 258], 'Zap-70,': [62, 80, 185, 203, 471, 3715, 3934], 'binds': [64, 187, 3724], 'both': [66, 189, 2606, 2675, 3098, 3240, 3850, 4312, 4609], 'plays': [70, 193, 1687], 'adaptor': [72, 195, 1121, 1689, 3657, 3693, 4133], 'role': [73, 196, 512, 1593, 1690, 3194, 3599, 3713, 4057, 4383, 4471], 'in': [74, 78, 197, 201, 447, 473, 482, 517, 551, 593, 669, 767, 826, 874, 1237, 1507, 1596, 1691, 1857, 1875, 1908, 2001, 2097, 2102, 2133, 2146, 2176, 2189, 2218, 2244, 2371, 2435, 2556, 2579, 2583, 2634, 2693, 2773, 2817, 2897, 3031, 3033, 3081, 3199, 3218, 3281, 3314, 3331, 3439, 3510, 3533, 3554, 3587, 3595, 3600, 3869, 3973, 4060, 4083, 4093, 4106, 4150, 4308, 4387, 4398, 4414, 4472, 4489, 4526, 4531], 'events.': [76, 199], 'Mutations': [77, 200, 2078], 'TCRζ,': [79, 202, 2665, 2791, 2923, 3318, 3653, 4064, 4080, 4220], 'or': [81, 91, 204, 214, 588, 1018, 1359, 1863, 1867, 1896, 1992, 1996, 2049, 2101, 2113, 2228, 2383, 2586, 2596, 2604, 2776, 2910, 2914, 3074, 3460, 3516, 3656, 3759, 4029, 4086, 4263, 4343, 4403, 4562, 4597], 'Cbl': [82, 95, 108, 205, 218, 231, 1265, 1294, 1343, 1492, 1560, 1595, 1611, 1627, 1644, 1706, 1986, 1991, 1993, 2033, 2100, 2103, 2724, 2757, 2779, 2783, 2813, 2906, 3014, 3022, 3062, 3073, 3075, 3118, 3200, 3219, 3252, 3311, 3386, 3391, 3440, 3448, 3451, 3489, 3515, 3546, 3645, 3663, 3681, 3726, 3846, 3877, 3894, 3945, 3974, 4082, 4097, 4115, 4135, 4584, 4592, 4604], 'disrupt': [84, 207, 2313, 3018, 3890, 3983], 'interaction': [86, 209, 3020, 3892, 3985, 4327, 4451], 'between': [87, 92, 210, 215, 931, 1003, 3133], 'Zap-70': [90, 93, 213, 216, 1677, 1686, 1889, 1909, 3791, 3800, 3826, 3848, 3870, 3935, 3987, 4059, 4090, 4117, 4128, 4335, 4375, 4402, 4450], 'reduce': [96, 219, 1671], 'TCRζ.': [99, 222, 2544, 2762, 3223, 3326, 3446, 3474, 3676, 3705, 4122, 4141, 4458], 'Our': [100, 223, 1698], 'results': [101, 224, 592, 1699, 2803, 3372], 'suggest': [102, 225, 2804, 3565, 3689, 4126, 4440], 'novel': [104, 227], 'mechanism': [105, 228, 912, 1057, 1703], 'by': [106, 116, 229, 239, 274, 281, 386, 396, 487, 544, 584, 841, 991, 1064, 1307, 1704, 1711, 1772, 1782, 1832, 1882, 1912, 2063, 2107, 2123, 2163, 2205, 2290, 2334, 2408, 2433, 2648, 2671, 2796, 3817, 3843, 4022, 4590], 'negatively': [109, 232], 'regulates': [110, 233, 1707], 'development': [113, 236, 1599], 'activation': [115, 238, 254, 271, 382, 430, 485], 'inducing': [117, 240, 3555], 'TCR·CD3': [121, 244, 597, 657, 749, 756, 1503, 4143], 'components.': [122, 245], 'major': [246, 282], 'histocompatibility': [247, 283], 'immunoreceptor': [252, 380], 'tyrosine-based': [253, 381], 'motif': [255], 'protein': [256, 435, 922, 1020, 1122, 1230, 1763, 2144, 2187, 2303, 2341, 3722], 'Ub-conjugating': [260, 1357], 'enzyme': [261, 994, 1014, 1358], 'Ub-protein': [262, 2729], 'ligase': [263, 1349, 1617, 2730, 2816, 3029, 3202, 3279], 'hemagglutinin': [268], 'is': [272, 333, 373, 500, 541, 659, 676, 839, 988, 1008, 1339, 1505, 1607, 1683, 3646, 3714, 3718, 3871], 'initiated': [273], 'binding': [276, 455, 1067, 3125, 3272, 3873, 4373], 'antigenic': [278], 'peptides': [279], 'presented': [280], 'complexes': [284], '(MHCs)1': [285], 'on': [286, 425, 3065, 3111, 3540, 3795, 3833, 3927, 4017, 4236, 4245, 4325, 4446, 4462, 4585], 'presenting': [289, 556, 672], 'cells': [290, 691, 770, 2112, 2150, 2173, 2192, 2211, 2582, 2592, 2658, 2765, 2901, 4073, 4108, 4332], '(TCR)': [296], '(1Weiss': [297, 3768], 'A.': [298, 600, 602, 619, 635, 639, 697, 703, 802, 852, 973, 975, 1138, 1190, 1256, 1393, 1439, 1447, 1551, 1581, 2013, 2511, 2865, 2973, 3630, 3632, 3769, 4187], 'Littman': [299, 3770], 'D.R.': [300, 3771], 'Cell.': [301, 731, 1196, 1399, 1474, 1527, 3157, 3772], '1994;': [302, 900, 3773, 4507], '76:': [303, 3774], '263-274Abstract': [304, 3775], 'Full': [305, 321, 323, 530, 532, 646, 648, 735, 811, 813, 861, 863, 903, 1076, 1078, 1200, 1202, 1328, 1330, 1403, 1405, 1456, 1458, 1478, 1480, 1941, 1943, 1975, 1977, 2022, 2024, 2520, 2522, 2874, 2876, 2982, 2984, 3161, 3163, 3420, 3422, 3744, 3746, 3776, 3909, 3911, 4002, 4004, 4196, 4198, 4510], 'Text': [306, 322, 324, 531, 533, 647, 649, 736, 812, 814, 862, 864, 904, 1077, 1079, 1201, 1203, 1329, 1331, 1404, 1406, 1457, 1459, 1479, 1481, 1942, 1944, 1976, 1978, 2023, 2025, 2521, 2523, 2875, 2877, 2983, 2985, 3162, 3164, 3421, 3423, 3745, 3747, 3777, 3910, 3912, 4003, 4005, 4197, 4199, 4511], 'PDF': [307, 325, 534, 650, 737, 815, 865, 905, 1080, 1204, 1332, 1407, 1460, 1482, 1945, 1979, 2026, 2524, 2878, 2986, 3165, 3424, 3748, 3778, 3913, 4006, 4200, 4512], 'PubMed': [308, 326, 535, 575, 607, 626, 651, 710, 738, 791, 816, 866, 906, 967, 982, 1081, 1142, 1166, 1205, 1260, 1333, 1408, 1429, 1461, 1483, 1532, 1555, 1585, 1946, 1980, 2027, 2500, 2525, 2747, 2854, 2879, 2962, 2987, 3052, 3166, 3299, 3349, 3425, 3624, 3639, 3749, 3779, 3914, 4007, 4175, 4201, 4513], 'Scopus': [309, 327, 536, 576, 608, 627, 711, 739, 792, 817, 867, 968, 983, 1082, 1143, 1167, 1206, 1261, 1334, 1409, 1430, 1462, 1484, 1533, 1556, 1586, 1947, 1981, 2028, 2501, 2526, 2748, 2855, 2880, 2963, 2988, 3053, 3167, 3300, 3350, 3426, 3625, 3640, 3750, 3780, 3915, 4008, 4176, 4202], '(1955)': [310, 3781], 'Google': [311, 329, 538, 578, 610, 629, 652, 713, 741, 794, 819, 869, 907, 970, 985, 1084, 1145, 1169, 1208, 1263, 1336, 1411, 1432, 1464, 1486, 1535, 1558, 1588, 1949, 1983, 2030, 2503, 2528, 2750, 2857, 2882, 2965, 2990, 3055, 3169, 3302, 3352, 3428, 3627, 3642, 3752, 3782, 3917, 4010, 4178, 4204, 4514], 'Scholar,': [312, 611, 630, 714, 795, 971, 1146, 1170, 1412, 1433, 1465, 1536, 1950, 2504, 2858, 2966, 3628], '2Wange': [313], 'R.L.': [314], 'Samelson': [315], 'L.E.': [316], 'Immunity.': [317, 526, 642], '1996;': [318, 604, 808, 858, 964, 2517, 2871, 2979, 3621, 4193], '5:': [319], '197-205Abstract': [320], '(462)': [328], 'Scholar).': [330, 579, 653, 742, 820, 870, 908, 986, 1085, 1209, 1264, 1337, 1487, 1559, 1984, 2031, 2529, 2883, 3056, 3170, 3303, 3429, 3643, 3783, 3918, 4011, 4515], 'TCR': [332, 346, 418, 583, 829, 2471, 2825], 'assembled': [334], 'as': [335, 1094, 1218, 1345, 1613, 1630, 1793, 2463, 2725, 2809, 3487, 3685, 3763, 4044, 4131, 4261, 4429, 4567], 'multiple': [337, 489, 4490], 'subunit': [338, 403], 'consists': [341, 1266, 3392], 'specific': [344, 1027], 'antigen-binding': [345], 'α': [347], 'β': [349], 'heterodimer,': [350], 'signal-transducing': [351], 'invariant': [352], 'CD3γ,': [353], 'δ,': [354], 'ε': [355], 'chains,': [356], 'structurally': [359], 'distinct': [360], 'chain.': [362, 1697, 1716], 'signal': [364, 1061], 'capacity': [365], 'CD3': [368, 402, 448], 'subunits': [369, 449], 'chain': [372, 409, 452, 516, 549, 824, 880, 915, 1606, 1635, 1778, 1784, 1834, 2065, 2476, 2567, 4487], 'achieved': [374], 'through': [375, 428, 1108], 'phosphorylation': [377, 421, 444, 1284], 'motifs': [383], '(ITAMs),': [384], 'characterized': [385, 3721], 'presence': [388, 2587, 2673, 2777, 4088, 4400], 'pair': [391], 'YXX(L/I)': [393], 'sequences': [394, 3405], 'separated': [395], '6–8': [397], 'variable': [398, 4286], 'amino': [399, 2046, 2058], 'acids.': [400], 'Each': [401], 'has': [404, 410, 764, 1920, 3537, 3792, 4480], 'one': [405], 'copy,': [406], 'three': [411, 1855, 4234, 4300, 4444], 'copies': [412], 'ITAMs.': [414], 'Engagement': [415, 580], 'rapid': [420], 'residues': [424, 873, 943, 4231, 4493, 4525, 4539], 'ITAMs': [427, 446, 1670, 1856, 4235, 4271, 4301, 4386, 4445], 'family': [434, 467, 1088, 1295, 3253], 'kinases': [437, 1092, 1370, 1621], '(PTKs)': [438], 'Lck': [439], 'Fyn.': [441], 'creates': [453], 'sites': [456, 883, 3126, 3146], 'for': [457, 513, 682, 884, 1026, 1031, 1097, 1371, 1594, 1618, 1633, 2232, 2279, 2297, 2330, 2350, 2447, 2812, 3127, 3385, 3441, 3578, 3662, 3711, 3875, 4058, 4134], '(SH2)': [462], 'domains': [463], 'Syk': [466, 469], 'PTKs': [468, 481], 'resulting': [472], 'their': [474, 3598, 4586], 'subsequent': [475, 3614, 4454], 'recruitment': [476, 3602], 'activation.': [478, 497, 1601], 'activated': [480, 768, 989, 1367], 'turn': [483], 'propagate': [484], 'signals': [486], 'phosphorylating': [488], 'intracellular': [490, 876, 1304, 4491, 4528], 'proteins,': [491, 2688], 'eventually': [492], 'leading': [493, 747], 'Of': [498, 3171, 4361], 'note': [499], 'fact': [502, 1603], 'biochemical': [504, 1289], 'genetic': [506, 1287, 1489], 'studies': [507, 1290, 1490, 2466, 2821, 3863, 3966], 'documented': [509, 3968], 'critical': [511], 'transducing': [518], 'signaling': [520, 668, 1305], 'processes': [521], '(3Love': [522], 'P.E.': [523], 'Shores': [524], 'E.W.': [525], '2000;': [527, 572, 643, 1475, 1972, 3158], '12:': [528, 644], '591-597Abstract': [529], '(71)': [537], 'Scholar),': [539, 1589, 2991, 3353], 'further': [542, 2669, 2794, 3305, 3815, 3828, 4053, 4211, 4380], 'supported': [543], 'formation': [546, 930, 2636], 'clustering': [550], 'cell-': [554], 'interface': [558], 'during': [559], 'recognition': [562, 1029], '(4Krummel': [563], 'M.F.': [564], 'Sjaastad': [565], 'M.D.': [566], 'Wulfing': [567], 'C.': [568, 772, 797, 847, 890, 1932, 1954, 1960, 2011, 2481, 2506, 2835, 2860, 2943, 2968, 4156, 4182, 4497], 'Davis': [569], 'M.M.': [570], 'Science.': [571, 603, 787, 1425, 2496, 2743, 2850, 2958, 3048, 3295, 3345, 4171], '289:': [573], '1349-1352Crossref': [574], '(330)': [577], 'peptide-MHC': [586], 'anti-TCR·CD3': [589], 'antibodies': [590, 1727, 2327, 2403, 2462], 'also': [591, 677, 1628, 2830, 3143, 3320, 3703, 3755, 3982, 4425], 'down-regulation': [594], '(5Viola': [599], 'Lanzavecchia': [601, 618], '273:': [605, 2020], '104-106Crossref': [606], '(876)': [609], '6Valitutti': [612], 'S.': [613, 615, 1124, 1137, 1184, 1192, 1255, 1387, 1395, 1550, 1580], 'Muller': [614], 'Salio': [616], 'M.': [617, 722, 960, 1178, 1381, 1435, 1441, 1538, 1568, 2009, 3617], 'J.': [620, 704, 805, 855, 897, 1162, 1450, 1935, 1969, 2016, 2514, 2868, 2976, 4190, 4504], 'Exp.': [621, 705], 'Med.': [622, 706], '1997;': [623], '185:': [624], '1859-1864Crossref': [625], '(265)': [628], '7San': [631], 'Jose': [632], 'E.': [633], 'Borroto': [634], 'Niedergang': [636], 'F.': [637, 720], 'Alcover': [638], 'Alarcon': [640], 'B.': [641, 726, 730, 1129], '161-170Abstract': [645], 'Down-regulation': [654], 'considered': [660], 'self-limiting': [662], 'factor': [663], 'terminate': [665], 'sustained': [667], 'cell-antigen': [671], 'conjugates': [674], 'proposed': [678], 'be': [680, 2560, 2892, 3660, 4552], 'responsible': [681, 1025, 3577], 'unresponsiveness': [683], 'and/or': [684], 'tolerance': [685], 'induction': [686], 'self-reactive': [689], '(8Pantaleo': [692], 'G.': [693, 716, 1172, 1375], 'Olive': [694], 'D.': [695, 774, 888, 1924, 1964, 2483, 2837, 2945, 4158, 4495], 'Poggi': [696], 'Pozzan': [698], 'T.': [699, 1422, 1437, 1966, 2740, 3045, 3292, 3342], 'Moretta': [700, 702], 'L.': [701, 1069, 1517, 1952], '1987;': [707], '166:': [708], '619-624Crossref': [709], '(63)': [712], '9Schonrich': [715], 'Kalinke': [717], 'U.': [718, 1136, 1254, 1549, 1579], 'Momburg': [719], 'Malissen': [721, 725], 'Schmitt-Verhulst': [723], 'A.M.': [724, 786, 804, 854, 896, 2495, 2513, 2849, 2867, 2957, 2975, 4170, 4189, 4503], 'Hammerling': [727], 'G.J.': [728], 'Arnold': [729], '1991;': [732], '65:': [733], '293-304Abstract': [734], '(483)': [740], 'Among': [743], 'all': [744, 2712, 4297, 4362], 'potential': [745, 882, 1282, 3709], 'pathways': [746], 'down-regulation,': [750], '(Ub)': [752], 'subunits,': [757], 'particularly': [759], 'shown': [766, 1292, 1684, 2468, 3004, 4481], '(10Cenciarelli': [771, 2480, 2834, 2942], 'Hou': [773, 2482, 2836, 2944, 4157], 'Hsu': [775, 2484, 2838, 2946, 4159], 'K.C.': [776, 2485, 2839, 2947, 4160], 'Rellahan': [777, 2486, 2840, 2948, 4161], 'B.L.': [778, 2487, 2841, 2949, 4162], 'Wiest': [779, 2488, 2842, 2950, 4163], 'D.L.': [780, 2489, 2843, 2951, 4164], 'Smith': [781, 2490, 2844, 2952, 4165], 'H.T.': [782, 2491, 2845, 2953, 4166], 'Fried': [783, 2492, 2846, 2954, 4167], 'V.A.': [784, 2493, 2847, 2955, 4168], 'Weissman': [785, 803, 853, 895, 2494, 2512, 2848, 2866, 2956, 2974, 4169, 4188, 4502], '1992;': [788, 2497, 2851, 2959, 4172], '257:': [789, 2498, 2852, 2960, 4173], '795-797Crossref': [790, 2499, 2853, 2961, 4174], '(185)': [793, 2502, 2856, 2964, 4177], '11Cenciarelli': [796, 2505, 2859, 2967, 4181], 'Wilhelm': [798, 848, 2507, 2861, 2969, 4183], 'Jr.,': [799, 849, 1126, 1315, 2508, 2862, 2970, 3407, 3731, 3896, 3989, 4184], 'K.G.': [800, 850, 2509, 2863, 2971, 4185], 'Guo': [801, 851, 2510, 2864, 2972, 4186], 'Biol.': [806, 856, 898, 1072, 1451, 1528, 1936, 1970, 2017, 2515, 2869, 2977, 4191, 4505], 'Chem.': [807, 857, 899, 1452, 1937, 1971, 2018, 2516, 2870, 2978, 4192, 4506], '271:': [809, 859, 2518, 2872, 2980, 4194], '8709-8713Abstract': [810, 860, 2519, 2873, 2981, 4195], '(72)': [818, 868, 2527, 2881, 2989, 4203], 'Ubiquitination': [821, 919, 1049], 'occurs': [825, 924, 2996, 4488], 'response': [827], 'triggering,': [830], 'upon': [831, 1110], 'treatment': [832, 2798], 'with': [833, 1281, 1350, 1803, 1815, 1897, 1997, 2071, 2136, 2153, 2179, 2195, 2225, 2326, 2363, 2399, 2419, 2453, 2460, 2569, 2599, 2605, 2619, 2626, 2631, 2659, 2702, 2768, 2784, 2827, 2903, 2912, 2930, 2939, 3023, 3071, 3079, 3147, 3183, 3222, 3226, 3325, 3329, 3473, 3512, 3545, 3652, 3669, 3697, 3704, 3801, 3893, 3932, 3944, 3986, 4025, 4046, 4076, 4116, 4296, 4328, 4334, 4345, 4352, 4359, 4431, 4569], 'phosphatase': [835, 2602], 'inhibitor,': [836, 2603, 2612], 'pervanadate,': [837, 2226, 2600], 'inhibited': [840], 'PTK': [843], 'inhibitor': [844], 'herbimycin': [845], '(11Cenciarelli': [846], 'Multiple': [871], 'lysine': [872, 942, 4492, 4524, 4538], 'are': [881, 1022, 3383, 3575, 3584, 4522], 'Ub': [885, 936, 987, 1004, 1033, 1047, 1115, 1348, 1372, 1647, 1693, 1918, 2541, 2662, 2788, 2815, 2887, 2920, 3093, 3315, 3443, 3479, 3556, 3589, 3609, 3674, 3804, 3836, 3948, 4100, 4138, 4148, 4274, 4407, 4474, 4483, 4565, 4606], 'attachment': [886], '(12Hou': [887, 4494], 'Cenciarelli': [889, 4496], 'Jensen': [891, 4498], 'J.P.': [892, 4499], 'Nguygen': [893, 4500], 'H.B.': [894, 4501], '269:': [901, 4508], '14244-14247Abstract': [902, 4509], 'underlying': [913, 2540, 4216], 'remains': [917], 'unclear.': [918], 'substrate': [923, 946, 1028, 2811, 3593, 3612], 'via': [925], 'covalent': [927], 'isopeptide': [928], 'bond': [929, 1002], 'C-terminal': [933, 1278, 2054, 3403, 3466], 'glycine': [934, 3975], 'ε-amino': [939], 'group': [940], 'involves': [948, 1118], 'cascade': [950], 'enzymatic': [952], 'reactions': [953], 'E1,': [955], 'E2,': [956, 3129, 3605], '(13Hochstrasser': [959, 3616], 'Annu.': [961, 976, 3618, 3633], 'Rev.': [962, 977, 3619, 3634], 'Genet.': [963, 3620], '30:': [965, 3622], '405-439Crossref': [966, 3623], '(1459)': [969, 3626], '14Hershko': [972, 3629], 'Ciechanover': [974, 1189, 1392, 3631], 'Biochem.': [978, 3635], '1998;': [979, 1139, 1529, 1552, 1582, 2019, 3636], '67:': [980, 3637], '425-479Crossref': [981, 3638], '(6907)': [984, 3641], 'first': [990, 2547, 4258, 4269, 4464, 4545], 'activating': [993], '(E1)': [995], 'form': [997, 3179, 3665], 'high': [999], 'energy': [1000], 'thiolester': [1001], 'E1': [1006], 'then': [1009, 2240, 2415, 2458, 3521, 3920, 4318, 4460], 'transferred': [1010], 'conjugating': [1013], '(E2).': [1015], 'E3s': [1017, 1041], 'Ub-': [1019], 'ligases': [1021, 3583], 'components': [1024, 2472, 3586], 'promoting': [1032, 1712], 'ligation': [1034], 'target': [1037], 'protein.': [1038], 'Therefore,': [1039], 'can': [1042, 2559, 2758, 2807, 3017, 3695, 3889, 3981, 4129, 4448], 'provide': [1043, 1700], 'specificity': [1044], 'system.': [1048], 'receptors': [1053, 1096, 1313], 'represents': [1054], 'general': [1056], 'turning': [1059], 'off': [1060], 'transduction': [1062], 'induced': [1063, 1306, 2893, 3478, 4099, 4605], 'ligand': [1066], '(15Hicke': [1068], 'Trends': [1070], 'Cell': [1071], '1999;': [1073, 1163, 1197, 1325, 1400, 1426, 1453, 2744, 3049, 3296, 3346, 3417, 3741, 3906, 3999], '9:': [1074], '107-112Abstract': [1075], '(386)': [1083], 'Particularly,': [1086], 'such': [1093], 'epidermal': [1098], 'growth': [1099, 1102], 'factor,': [1100, 1103], 'platelet-derived': [1101], 'colony-stimulating': [1105], 'factor-1': [1106], 'go': [1107], 'engagement,': [1112], 'this': [1114, 2564, 3196, 3265, 3712, 3885, 3925, 4015], 'process': [1117], '(16Miyake': [1123], 'Lupher': [1125], 'M.L.': [1127, 1316, 3408, 3732, 3897, 3990], 'Druker': [1128], 'Band': [1130, 1321, 3413, 3737, 3902, 3995], 'H.': [1131, 1174, 1322, 1377, 1418, 1445, 1544, 1574, 2736, 3041, 3288, 3338, 3414, 3738, 3903, 3996], 'Proc.': [1132, 1250, 1545, 1575], 'Natl.': [1133, 1251, 1546, 1576], 'Acad.': [1134, 1252, 1547, 1577], 'Sci.': [1135, 1253, 1548, 1578], '95:': [1140, 1553, 1583], '7927-7932Crossref': [1141], '(236)': [1144], '17Lee': [1147], 'P.S.': [1148], 'Wang': [1149, 1468, 1925, 1957, 3151], 'Y.': [1150, 1188, 1194, 1391, 1397, 1930, 1962], 'Dominguez': [1151], 'M.G.': [1152], 'Yeung': [1153], 'Y.G.': [1154], 'Murphy': [1155], 'M.A.': [1156, 1511], 'Bowtell': [1157, 1524], 'D.D.': [1158, 1525], 'Stanley': [1159], 'E.R.': [1160], 'EMBO': [1161], '18:': [1164, 1530], '3616-3628Crossref': [1165], '(252)': [1168], '18Levkowitz': [1171], 'Waterman': [1173, 1376], 'Ettenberg': [1175, 1378], 'S.A.': [1176, 1379], 'Katz': [1177, 1380], 'Tsygankov': [1179, 1382], 'A.Y.': [1180, 1383], 'Alroy': [1181, 1384], 'I.': [1182, 1385, 1519], 'Lavi': [1183, 1386], 'Iwai': [1185, 1388], 'K.': [1186, 1389], 'Reiss': [1187, 1390], 'Lipkowitz': [1191, 1394], 'Yarden': [1193, 1396], 'Mol': [1195, 1398], '4:': [1198, 1401], '1029-1040Abstract': [1199, 1402], '(835)': [1207, 1410], '120-kDa': [1212], 'proto-oncogene': [1213], 'product,': [1214], 'was': [1215, 1739, 1747, 1757, 1770, 1780, 1797, 1830, 1891, 2061, 2307, 2533, 2577, 2646, 2668, 2700, 2793, 3765, 3814, 3840, 4020, 4411, 4588], 'originally': [1216, 3766], 'isolated': [1217], 'cellular': [1220], 'homologue': [1221], 'v-Cbl,': [1223], 'part': [1225], 'transforming': [1228], 'fusion': [1229], 'CAS': [1232], 'NS-1': [1233], 'retrovirus': [1234], 'causing': [1235], 'leukemia': [1236], 'mice': [1238, 1494], '(19Langdon': [1239], 'W.Y.': [1240, 1523], 'Hartley': [1241], 'J.W.': [1242], 'Klinken': [1243], 'S.P.': [1244], 'Ruscetti': [1245], 'S.K.': [1246], 'Morse': [1247], 'H.C.': [1248], 'd.': [1249], '1989;': [1257], '86:': [1258], '1168-1172Crossref': [1259], '(283)': [1262], 'N-terminal': [1269, 1660, 1846, 2037, 3135, 3395, 3568, 3682], 'SH2': [1271, 1363, 1662, 2039, 3137, 3397, 3453, 3569, 3683, 3700, 3728, 3879], 'domain,': [1272, 3398], 'finger,': [1275, 3120, 3142, 3401], 'proline-rich': [1279, 2055, 3404], 'sites.': [1285], 'Indeed,': [1286], 'proteins': [1296, 3254], 'including': [1297, 2473, 4145], 'those': [1298], 'fromDrosophila': [1299], 'Caenorhabditis': [1301], 'elegans': [1302], 'attenuate': [1303], 'engagement': [1309], '(20Lupher': [1314, 3406, 3730, 3895, 3988], 'Rao': [1317, 3409, 3733, 3898, 3991], 'N.': [1318, 1467, 1928, 1956, 3150, 3410, 3734, 3899, 3992], 'Eck': [1319, 3411, 3735, 3900, 3993], 'M.J.': [1320, 3412, 3736, 3901, 3994], 'Immunol.': [1323, 3415, 3739, 3904, 3997], 'Today.': [1324, 3416, 3740, 3905, 3998], '20:': [1326, 3418, 3742, 3907, 4000], '375-382Abstract': [1327, 3419, 3743, 3908, 4001], '(121)': [1335, 3427, 3751, 3916, 4009], 'It': [1338], 'now': [1340], 'understood': [1341], 'functions': [1344, 1629], 'finger': [1353, 1657, 2044, 2052, 3016, 3313, 3378, 3458, 3463, 3526, 3574], 'recruits': [1355], 'E2': [1360, 3025, 3275], 'recognizes': [1366], '(18Levkowitz': [1374], '21Joazeiro': [1413], 'C.A.': [1414, 2732, 3037, 3284, 3334], 'Wing': [1415, 2733, 3038, 3285, 3335], 'S.S.': [1416, 2734, 3039, 3286, 3336], 'Huang': [1417, 2735, 3040, 3287, 3337], 'Leverson': [1419, 2737, 3042, 3289, 3339], 'J.D.': [1420, 2738, 3043, 3290, 3340], 'Hunter': [1421, 1965, 2739, 3044, 3291, 3341], 'Liu': [1423, 1933, 1967, 2014, 2741, 3046, 3293, 3343], 'Y.C.': [1424, 1934, 1968, 2015, 2742, 3047, 3294, 3344], '286:': [1427, 2745, 3050, 3297, 3347], '309-312Crossref': [1428, 2746, 3051, 3298, 3348], '(912)': [1431, 2749, 3054, 3301, 3351], '22Yokouchi': [1434], 'Kondo': [1436], 'Houghton': [1438], 'Bartkiewicz': [1440], 'Horne': [1442], 'W.C.': [1443], 'Zhang': [1444], 'Yoshimura': [1446], 'Baron': [1448], 'R.': [1449, 1773], '274:': [1454], '31707-31712Abstract': [1455], '(284)': [1463], '23Zheng': [1466], 'P.': [1469, 3152], 'Jeffrey': [1470, 3153], 'P.D.': [1471, 3154], 'Pavletich': [1472, 3155], 'N.P.': [1473, 3156], '102:': [1476, 3159], '533-539Abstract': [1477, 3160], '(721)': [1485, 3168], 'Two': [1488], 'using': [1491, 1761, 1786], 'gene-targeted': [1493], 'showed': [1495, 3114, 3502, 3551, 3865, 3938, 4304], 'expression': [1500, 2145, 2188, 2710], 'up-regulated': [1506], 'Cbl-deficient': [1508], 'thymocytes': [1509, 1566], '(24Murphy': [1510], 'Schnall': [1512], 'R.G.': [1513], 'Venter': [1514], 'D.J.': [1515], 'Barnett': [1516], 'Bertoncello': [1518], 'Thien': [1520], 'C.B.': [1521], 'Langdon': [1522], 'Mol.': [1526], '4872-4882Crossref': [1531], '(332)': [1534], '25Naramura': [1537], 'Kole': [1539, 1569], 'H.K.': [1540, 1570], 'Hu': [1541, 1571], 'R.-J.': [1542, 1572], 'Gu': [1543, 1573], '15547-15552Crossref': [1554, 1584], '(289)': [1557, 1587], 'deficiency': [1561], 'favors': [1562], 'positive': [1563], 'selection': [1564], '(25Naramura': [1567], 'suggesting': [1590, 2992], 'important': [1592], 'ubiquitinated': [1608, 2302], 'acts': [1612], 'prompted': [1622, 2752], 'us': [1623, 2753], 'investigate': [1625, 3192], 'whether': [1626, 2756, 2886, 3523, 3790, 3825, 4547], 'promote': [1637, 2759, 3388, 3507], 'show': [1642], 'indeed': [1645, 2918, 3841], 'Cbl.': [1665, 4404], 'Furthermore,': [1666], 'mutations': [1667, 1843, 1902, 4227, 4244, 4324], 'ubiquitination,': [1673, 3067, 3206, 3509, 4389], 'whereas': [1674, 4530], 'coexpression': [1675, 3844, 4113], 'enhances': [1678], 'event.': [1680], 'Significantly,': [1681, 4293], 'it': [1682, 3717, 3764], 'Cbl-induced': [1692, 3092, 4061], 'function': [1710], 'Polyclonal': [1717], 'anti-Cbl,': [1718], 'anti-TCRζ': [1719], 'anti-Zap-70': [1721], 'antibodies,': [1722], 'anti-Myc,': [1723], 'anti-HA': [1725, 2649], 'monoclonal': [1726, 1737, 1755, 1767], 'were': [1728, 1880, 1910, 2005, 2105, 2131, 2151, 2174, 2193, 2212, 2239, 2277, 2288, 2324, 2359, 2379, 2397, 2414, 2431, 2593, 2597, 2617, 2624, 2766, 2907, 2937, 3469, 4074, 4285, 4340, 4350, 4357, 4540], 'from': [1729, 1740, 1748, 1759], 'Santa': [1730, 2347], 'Cruz': [1731, 2345], 'Biotechnology': [1732], '(Santa': [1733, 2344], 'Cruz,': [1734, 2348], 'CA).': [1735, 1751], 'Anti-Zap-70': [1736], 'antibody': [1738, 1746, 1756, 1768, 2650], 'Transduction': [1741], 'Laboratories': [1742], '(Lexington,': [1743], 'KY).': [1744], 'Anti-Xpress': [1745], 'Invitrogen': [1749], '(Carlsbad,': [1750], 'Anti-human': [1752], 'CD3ε': [1753], '(OKT3)': [1754], 'purified': [1758], 'ascites': [1760], 'G-Sepharose': [1764, 2342], 'column.': [1765], 'Anti-TCRζ': [1766], '(H146-968)': [1769], 'provided': [1771, 2122], 'Kubo.': [1774], 'human': [1776, 1788, 1888], 'cDNA': [1779, 1790, 1890, 1919], 'amplified': [1781, 1831, 2062], 'polymerase': [1783, 1833, 2064], 'reaction': [1785, 1835, 2066], 'lymphocyte': [1789], 'library': [1791], '(CLONTECH)': [1792], 'template': [1795], 'subcloned': [1798, 1837, 1892, 2068], 'into': [1799, 1838, 1893, 2069, 2309], 'pEF': [1801, 1840, 1894, 2003], 'vector': [1802, 2004], 'in-frame': [1805], 'Myc': [1806, 2571], 'epitope': [1807, 2000, 2074, 2572], 'tag': [1808], 'at': [1809, 1844, 1851, 1903, 2075, 2079, 2235, 2282, 2292, 2355, 2450, 2573, 3007, 3086, 3212, 3264, 3528, 3884, 4228, 4249, 4256, 4267], '3′-end.': [1811], 'A': [1812, 2032, 3106, 4477], 'truncated': [1813, 4549, 4599, 4615], 'mutant': [1814, 3064, 3231, 3324, 3356, 3477, 3501, 3536, 3550, 3937, 4035, 4369, 4397, 4417], 'second': [1817, 1821], 'half': [1818], 'ITAM': [1822, 1826, 4259, 4465], 'third': [1825], 'removed': [1827, 2289], '(TCRζ': [1828, 1878], '1–121)': [1829], 'vector.': [1841], 'Point': [1842, 1901], 'residue': [1848, 3260, 3266, 4253], 'phenylalanine': [1850, 1907, 3888, 4255], 'each': [1852, 2272, 3437], 'wild-type': [1858, 3072, 3227, 3488, 3514, 3933, 4432], '(AYF,': [1860], 'ABYF,': [1861], 'ABCYF)': [1862], '1–121': [1865, 1877, 4519, 4555], '(AYF),': [1866], 'lysines': [1868], '115': [1869], '117': [1871], 'mutated': [1872, 4302, 4541], 'arginine': [1874, 3185, 3188], '1–121KR),': [1879], 'generated': [1881, 2106, 3208, 3470, 4222], 'site-directed': [1883, 1913, 2108], 'mutagenesis': [1884], '(QuickChange,': [1885], 'Stratagene).': [1886], 'without': [1895, 1995], 'Xpress': [1899], 'epitope.': [1900], '292': [1905, 3868], 'made': [1911, 2534], 'mutagenesis.': [1914, 2109], 'HA': [1916, 1999, 2073], 'epitope-tagged': [1917], 'described': [1922, 2006], '(26Fang': [1923], 'H.-Y.': [1926], 'Fang': [1927, 1955, 1963], 'Altman': [1929, 1961, 2012], 'Elly': [1931, 1959, 2010], '2001;': [1938], '276:': [1939], '4872-4878Abstract': [1940], '(159)': [1948], '27Qiu': [1951], 'Joazeiro': [1953], 'H.Y.': [1958], '275:': [1973], '35734-35737Abstract': [1974], '(266)': [1982], 'cDNAs': [1987], 'encoding': [1988], 'full-length': [1990, 2099, 4571, 4595, 4611], 'G306E': [1994, 4031, 4034], 'previously': [2007, 3003], '(28Deckert': [2008], '8867-8874Abstract': [2021], '(105)': [2029], 'construct': [2034], 'containing': [2035, 3450, 4078], '(SH2+RING,': [2045], 'acids': [2047, 2059, 3175], '1–481),': [2048], '(RING+C,': [2057], '355–906)': [2060], 'pEFneo': [2070], '5′-end.': [2077], 'glutamic': [2080, 3174, 3213, 3978], 'acid': [2081, 3214, 3979], '369': [2082, 3178, 3215], 'alanine': [2084, 2089, 2095, 3011, 3090, 3217, 3268, 3532], '(E369A),': [2085], 'cysteine': [2086, 3008, 3087, 3529], '381': [2087, 3009, 3088, 3530], '(C381A),': [2090], 'tryptophan': [2092, 3259], '408': [2093], '(W408A)': [2096, 3269], '1–481': [2104], 'Jurkat': [2110, 2116, 2147, 2580, 2763, 4094, 4330], 'Zap-70-deficient': [2115, 4068], 'line': [2119], '(P116;': [2120], 'kindly': [2121], 'Dr.': [2124], 'Bob': [2125], 'Abraham,': [2126], 'Duke': [2127], 'University,': [2128], 'Durham,': [2129], 'NC)': [2130], 'cultured': [2132, 2175], 'RPMI': [2134], 'supplemented': [2135, 2178], '10%': [2137, 2180, 2384], 'fetal': [2138, 2181], 'bovine': [2139, 2182], 'serum': [2140, 2183], 'antibiotics.': [2142, 2185], 'For': [2143, 2186, 2300, 2317, 2563], 'cells,': [2149, 2191, 4096], 'transfected': [2152, 2194, 2902, 4075], 'appropriate': [2155, 2197], 'amount': [2156, 2198], 'plasmids': [2158, 2200, 2772, 4077], '(usually': [2159, 2201, 2404], '1–10': [2160], 'µg': [2161, 2203], 'total)': [2162, 2204], 'electroporation': [2164], '(240': [2165], 'V,': [2166], '960': [2167], 'microfarads;': [2168], 'Bio-Rad).': [2169], '293T': [2170, 2190, 4070, 4107], 'kidney': [2171], 'embryonic': [2172], 'DMEM': [2177], '1–4': [2202], 'calcium': [2206], 'precipitation.': [2207], 'After': [2208], '48': [2209], 'h,': [2210], 'collected,': [2213], 'resuspended': [2214, 2243], '(2': [2215], '×': [2216, 2294, 2321], '107/ml)': [2217], '0.5': [2219], 'ml': [2220], 'medium,': [2222], 'treated': [2224, 2598], 'OKT3,': [2227], 'MG132': [2229], '(50': [2230], 'µm)': [2231], '30': [2233, 2338], 'min': [2234, 2281], '37': [2236], '°C.': [2237, 2357], 'Cells': [2238, 2276], 'pelleted': [2241], '1×': [2245, 2364], 'Nonidet': [2246, 2251, 2365], 'P-40': [2247, 2366], 'lysis': [2248, 2310, 2367, 2695], 'buffer': [2249, 2311, 2368, 2437], '(1%': [2250], 'P-40,': [2252], '20': [2253, 2372], 'mm': [2254, 2259, 2262, 2265, 2439], 'Tris-HCl,': [2255, 2440], 'pH': [2256, 2441], '7.5,': [2257], '150': [2258], 'NaCl,': [2260], '5': [2261, 2264, 4291, 4377, 4419, 4435], 'EDTA,': [2263], 'NaPiP,': [2266], 'mmNa3VO4,': [2268], '10': [2270, 2280, 2298], 'µg/ml': [2271], 'aprotinin': [2273], 'leupeptin).': [2275], 'lysed': [2278], '4': [2283, 2356, 3856, 3859, 3953, 4050, 4110], '°C,': [2284], 'insoluble': [2286], 'materials': [2287], 'centrifugation': [2291], '15,000': [2293], 'g(4': [2295], '°C': [2296, 2452], 'min).': [2299], 'displaying': [2301], 'bands,': [2304], '0.1%': [2305, 2691], 'SDS': [2306, 2692], 'added': [2308, 2690], 'nonspecific': [2314, 2684], 'protein-protein': [2315], 'interaction.': [2316], 'immunoprecipitation,': [2318], 'lysates': [2319, 2616, 4349], '(∼1': [2320], '107': [2322], 'cells)': [2323], 'mixed': [2325], '(1': [2328], 'µg)': [2329], 'h': [2332, 2354, 2449], 'followed': [2333, 2407], 'addition': [2336, 3596], 'µl': [2339, 2373], 'beads': [2343], 'Biotechnology,': [2346], 'CA)': [2349], 'additional': [2352], 'Immunoprecipitates': [2358], 'washed': [2360, 2416], 'four': [2361], 'times': [2362], 'boiled': [2370], '2×': [2375], "Laemmli's": [2376], 'buffer.': [2377, 2696], 'Samples': [2378], 'subjected': [2380], '8': [2382], 'SDS-polyacrylamide': [2385], 'gel': [2386], 'electrophoresis': [2387], 'analysis,': [2388], 'electrotransferred': [2390], 'onto': [2391], 'polyvinylidene': [2392], 'difluoride': [2393], 'membranes': [2394, 2430], '(Millipore).': [2395], 'Membranes': [2396, 2413], 'probed': [2398], 'indicated': [2401], 'primary': [2402, 3124], '1': [2405, 2448, 2716, 2800], 'µg/ml),': [2406], 'horseradish': [2409], 'peroxidase-conjugated': [2410], 'secondary': [2411], 'antibodies.': [2412], 'visualized': [2418], 'enhanced': [2420, 2670, 2795, 3803, 3816], 'chemiluminescence': [2421], 'detection': [2422], 'system': [2423, 2555, 3035, 3590], '(ECL,': [2424], 'Amersham': [2425], 'Pharmacia': [2426], 'Biotech).': [2427], 'When': [2428], 'necessary,': [2429], 'stripped': [2432], 'incubation': [2434], 'stripping': [2436], '(62.5': [2438], '5.7,': [2442], '100': [2443], 'mm2-mercaptoethanol,': [2444], '2%': [2445], 'SDS)': [2446], '70': [2451], 'constant': [2454], 'agitation,': [2455], 'washed,': [2456], 'reprobed': [2459, 2701], 'other': [2461, 2687], 'indicated.': [2464], 'Previous': [2465, 2820, 3862, 3965], 'undergo': [2477], 'activation-dependent': [2478, 4152], 'present': [2531, 4208], 'study': [2532, 3110, 4479], 'determine': [2536], 'As': [2545, 3224, 3543, 3930], 'step,': [2548], 'tried': [2550], 'establish': [2552], 'anin': [2553], 'vivo': [2554], 'properly': [2561], 'ubiquitinated.': [2562, 4553], 'purpose,': [2565], 'tagged': [2568], 'C': [2575], 'terminus': [2576], 'expressed': [2578], 'absence': [2585, 2775, 4085], 'HA-tagged': [2589], 'Ub.': [2590], 'left': [2594, 2908, 4341], 'untreated': [2595], 'pervanadate': [2607, 2660, 2676, 2797, 2931, 3818], 'MG132,': [2609], 'proteasome': [2611], 'immunoprecipitated': [2618, 4351], 'anti-Myc': [2620, 2703, 4353], 'antibody.': [2621, 4354], 'immunoprecipitates': [2623, 4356], 'immunoblotted': [2625, 4358], 'anti-HA.': [2627], 'Coexpression': [2628, 2781, 3798], 'HA-Ub': [2630, 2771], 'resulted': [2633], 'slow': [2639], 'migrating,': [2640], 'higher': [2641], 'weight': [2643], 'smear': [2644], 'recognized': [2647], '(Fig.1': [2651, 2933], 'a,': [2652, 2717], 'top': [2653], 'panel).': [2654, 2719], 'Treatment': [2655], 'increased': [2661, 3842], 'MG132.': [2678], 'To': [2679, 2884, 3057, 3191, 3304, 4052, 4210, 4379], 'eliminate': [2680], 'interference': [2682], 'co-precipitation': [2685], 'same': [2698, 4423], 'membrane': [2699], 'antibody,': [2704], 'showing': [2705], 'equivalent': [2706], 'amounts': [2707], 'among': [2711, 4287], 'samples': [2714], '(Fig.': [2715, 2799, 3103, 3245, 3366, 3490, 3855, 3952, 4049, 4109, 4290, 4376, 4418, 4434], 'bottom': [2718], 'recent': [2721, 3107], 'identification': [2722], '(21Joazeiro': [2731, 3036, 3283, 3333], 'Scholar)': [2751, 3753], 'examine': [2755, 2885, 3058], 'cotransfected': [2767], 'plasmid.': [2780, 4091], 'significantly': [2786], 'augmented': [2787, 2919, 4119], 'b).': [2801, 3247, 3368, 3561, 4378], 'act': [2808, 4130], 'cells.': [2819, 4071], 'demonstrated': [2823, 3686], 'cross-linking': [2826], 'OKT3': [2828, 2913, 2916], 'could': [2829, 2891, 3827, 4551], 'induce': [2831, 3236, 3947, 4041, 4137], 'under': [2894, 2997, 3097, 3239, 3361, 3493, 3808, 3849, 4311, 4573], 'OKT3-stimulated': [2895], 'conditions': [2896, 3102, 3244, 3365, 3854, 4577], 'our': [2898, 3080, 3330], 'system,': [2899], 'unstimulated': [2909, 4342], 'stimulated': [2911, 4344], 'pervanadate.': [2915, 4346], 'stimulation': [2917, 2932, 2999, 3819], 'although': [2924, 3958, 4282], 'lesser': [2927], 'degree': [2928, 3486], 'than': [2929], 'c).': [2934, 4051, 4420], 'data': [2936, 3563, 4124, 4439], 'consistent': [2938], 'previous': [2940, 4478], 'publications': [2941], 'physiologic': [2998], 'conditions.': [3000, 3497, 4316], 'We': [3001, 3430, 3520, 3784, 3822, 3919, 4317, 4459, 4544], 'mutation': [3006, 3085, 3211, 3263, 3527, 3883, 3926, 3972, 4016, 4266, 4295, 4424], '(C381A)': [3012], 'Ubc': [3024, 3128, 3274], 'ablate': [3027], 'activity': [3030, 3203, 3280], 'vitro': [3034, 3082, 3282], 'effect': [3060, 3539, 3794, 3832, 3923, 4013, 4241, 4321, 4393, 4582], 'C381A': [3063, 3076, 3549], 'coexpressed': [3069, 3221, 3321, 3472, 4333], 'mutant.': [3077, 3519, 4032], 'Consistent': [3078], 'study,': [3083], 'abrogated': [3091], 'resting': [3099, 3241, 3362, 3494, 3809, 3851, 4313, 4574, 4602], 'pervanadate-stimulated': [3101, 3243, 3496, 3853, 4315, 4576], 'a).': [3105, 3821, 4292, 4579], 'crystal': [3108], 'structure': [3109], 'Cbl·UbcH7': [3112], 'besides': [3116], 'contains': [3122], 'link': [3131], 'region': [3132, 3198, 3382], 'forms': [3144], 'contact': [3145], 'UbcH7': [3148, 3184], '(23Zheng': [3149], 'note,': [3172], '366': [3176], 'intermolecular': [3180], 'hydrogen': [3181], 'bonds': [3182], '15': [3186], '5,': [3189], 'respectively.': [3190], 'linker': [3197, 3381], 'toward': [3204], 'point': [3210, 4226], 'compared': [3225, 3544, 3931, 4045, 4430, 4568], 'E369A': [3230], 'reduced': [3232, 3358, 3504, 3552, 3940, 4413, 4426, 4564], 'ability': [3234, 3505, 3553, 3941, 4039], 'fingers': [3250], 'contain': [3255], 'well': [3257, 3720], 'conserved': [3258], '(Trp-408),': [3261], 'reduces': [3270], 'eliminates': [3277], 'confirm': [3306, 4054], 'importance': [3308, 3678], 'W408A': [3323, 3355], 'In': [3327, 4516], 'agreement': [3328], 'vitrodata': [3332], 'severely': [3357, 4412], 'pervanadate-treated': [3364], 'Taken': [3369], 'together,': [3370], 'indicate': [3373], 'required': [3384, 3661], 'next': [3431, 3823], 'examined': [3432, 3921, 4391, 4546], 'requirement': [3435], 'Truncated': [3447], 'constructs': [3449], '(SH2+RING),': [3459], 'portion': [3467], '(RING+C)': [3468], 'SH2+RING': [3476, 3518, 3535, 4028, 4048], 'similar': [3485, 4561, 4619], '3': [3491], 'a),': [3492], 'RING+C': [3500], 'markedly': [3503, 4036, 4118], 'comparison': [3511], 'either': [3513, 4026], 'tested': [3522, 3786], 'SH2+RING,': [3547], '(Fig.3': [3560], 'collectively': [3564, 4125], 'primarily': [3576], 'mediate': [3592, 4449], 'recognition,': [3594], 'Ub-loaded': [3604], 'help': [3607], 'transfer': [3608, 3673, 4139], 'polyubiquitination': [3615], 'Because': [3644], 'known': [3648], 'associate': [3650], 'directly': [3651], 'intermediate': [3655], 'molecule': [3658, 3694], 'would': [3659], 'indirect': [3667], 'above': [3687], 'may': [3688], 'putative': [3692], 'interact': [3696], 'One': [3706], 'because': [3716], 'domian': [3729], '(Zap-70,': [3758], 'ζ': [3760], 'chain-associated': [3761], 'protein-70': [3762], 'named)': [3767], 'therefore': [3785], 'possibility': [3788], 'any': [3793, 4442], 'conditions,': [3810, 4603], '(Fig.4': [3820], 'assessed': [3824, 4021], 'augment': [3829], 'Cbl-mediated': [3831, 4427, 4455], 'b,': [3857, 3954], 'lanes': [3858, 3955], '10).': [3861], 'site': [3874, 3886], 'Y292F': [3936], 'cooperate': [3943], '6': [3956], 'and12),': [3957], 'substantial': [3959], 'level': [3960], 'remained.': [3964], 'loss-of-function': [3971], '306': [3976], '(G306E)': [3980], 'coexpressing': [4023, 4591], 'lost': [4037], "adaptor's": [4056], 'employed': [4066], 'non-lymphoid': [4069], 'HA-Ub,': [4079], 'Unlike': [4092], 'alone': [4098], 'only': [4104, 4366], 'slightly': [4105, 4563], 'd).': [4111, 4436], 'undergoes': [4147], 'manner': [4153], '(Refs.': [4154], '10Cenciarelli': [4155], 'Scholar': [4179, 4205], 'study).': [4209], 'dissect': [4212], 'Cbl-promoted': [4217], 'series': [4224], 'analyzed': [4239, 4319, 4589], 'Mutation': [4248], 'single': [4251], '(denoted': [4260], 'AYF)': [4262], 'double': [4265], 'two': [4270, 4537], '(ABYF)': [4272], 'affected': [4273], 'certain': [4280], 'degree,': [4281, 4620], 'effects': [4284], 'different': [4288], 'mutants': [4289, 4339, 4550, 4559, 4616], '(ABCYF)': [4303], 'marked': [4306], 'reduction': [4307], 'Zap-70.': [4329], 'anti-Zap-70.': [4360], 'mutants,': [4365], 'ABCYF': [4368, 4396, 4416], 'completely': [4370], 'disrupted': [4371], 'assess': [4381], 'Zap-70-induced': [4406], 'Similarly,': [4421], 'Collectively,': [4437], 'focused': [4461], 'analyze': [4469], 'process.': [4476], 'mutant,': [4520, 4534], 'there': [4521], 'five': [4523], 'portion,': [4529], '1–121KR': [4533, 4558], 'last': [4536], 'arginines.': [4543], 'displayed': [4560], '(Fig.6': [4578], 'Next,': [4580], 'mutants.': [4600], 'Under': [4601]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1996025404', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-21T01:52:59.828249', 'created_date': '2016-06-24'}
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