Title: The frequency of neuromyotonia in 37 patients previous diagnosed as benign cramp-fasciculation syndrome
Abstract:Introduction: Neuromyotonia (NM), Isaacs-Zschoke-Mertens syndrome or continuous muscle fiber activity (CMFA), is a rare condition associated to complexes VGKC-antibodies. Clinically, fasciculations, m...Introduction: Neuromyotonia (NM), Isaacs-Zschoke-Mertens syndrome or continuous muscle fiber activity (CMFA), is a rare condition associated to complexes VGKC-antibodies. Clinically, fasciculations, myokymias, muscle stiffness and a myotonic appearance of movements after contraction are typical findings. Rarely, bulbar muscles can be involved, mainly seen as twitching of the tongue, swallowing or speaking problems. Major differential diagnosis is the benign cramp-fasciculation syndrome (BFS), which can also be seen either in healthy people or as motorneuron pre-syndrome. In electromyography, spontaneous irregular discharges can be found frequently with typical di-, tri- or multiplet single motor unit discharges. In up to 80%, antibodies against VGKC-complexes can be detected. For symptomatic treatment, anticonvulsants like carbamazepine or pregabaline are recommended. Immunoglobulins and plasmapheresis are reported as successful treatments, sometimes immunosuppressive therapy is needed.Read More
Publication Year: 2014
Publication Date: 2014-03-12
Language: en
Type: article
Indexed In: ['crossref']
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