Publication Information

{'id': 'https://openalex.org/W1995568947', 'doi': 'https://doi.org/10.1158/1538-7445.cansusc14-11', 'title': 'Abstract 11: Evaluating cancer susceptibility mutations and incidental findings from whole exome sequencing of sequentially diagnosed pediatric solid and brain tumor patients: Early results of the BASIC3 study', 'display_name': 'Abstract 11: Evaluating cancer susceptibility mutations and incidental findings from whole exome sequencing of sequentially diagnosed pediatric solid and brain tumor patients: Early results of the BASIC3 study', 'publication_year': 2014, 'publication_date': '2014-12-01', 'ids': {'openalex': 'https://openalex.org/W1995568947', 'doi': 'https://doi.org/10.1158/1538-7445.cansusc14-11', 'mag': '1995568947'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.cansusc14-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5028969570', 'display_name': 'Sharon E. Plon', 'orcid': 'https://orcid.org/0000-0002-9626-0936'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sharon E. Plon', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057009671', 'display_name': 'Sarah Scollon', 'orcid': 'https://orcid.org/0000-0003-2017-0245'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarah Scollon', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074432182', 'display_name': 'Katie Bergstrom', 'orcid': 'https://orcid.org/0000-0002-0353-2278'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katie Bergstrom', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065679041', 'display_name': 'Robin A. Kerstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robin A. Kerstein', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083288793', 'display_name': 'Murali Chintagumpala', 'orcid': 'https://orcid.org/0000-0003-2686-6737'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Murali Chintagumpala', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078484599', 'display_name': 'Stacey L. Berg', 'orcid': 'https://orcid.org/0000-0003-2832-9994'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stacey L. Berg', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073398031', 'display_name': 'Susan G. Hilsenbeck', 'orcid': 'https://orcid.org/0000-0002-7962-673X'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Susan G. Hilsenbeck', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100453671', 'display_name': 'Tao Wang', 'orcid': 'https://orcid.org/0000-0003-1957-7160'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tao Wang', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053197785', 'display_name': 'Surya P. Rednam', 'orcid': 'https://orcid.org/0000-0001-8333-0758'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Surya Rednam', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003575856', 'display_name': 'David A. Wheeler', 'orcid': 'https://orcid.org/0000-0002-9056-6299'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David Wheeler', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072079955', 'display_name': 'Laurence B. McCullough', 'orcid': 'https://orcid.org/0000-0002-9505-0611'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurence McCullough', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033462351', 'display_name': 'Richard L. Street', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Street', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065618896', 'display_name': 'Amy L. McGuire', 'orcid': 'https://orcid.org/0000-0002-7819-519X'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amy L. McGuire', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066097440', 'display_name': 'Reid G. Jeffrey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Reid G. Jeffrey', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037749785', 'display_name': 'Donna M. Muzny', 'orcid': 'https://orcid.org/0000-0002-3055-0359'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donna M. Muzny', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107559949', 'display_name': 'Christine M. Eng', 'orcid': 'https://orcid.org/0009-0008-8627-8228'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christine M. Eng', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006293085', 'display_name': 'Yaping Yang', 'orcid': 'https://orcid.org/0000-0001-5608-8628'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yaping Yang', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059626751', 'display_name': 'Richard A. Gibbs', 'orcid': 'https://orcid.org/0000-0002-1356-5698'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard A. Gibbs', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041203888', 'display_name': 'D. Williams Parsons', 'orcid': 'https://orcid.org/0000-0002-8775-3501'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Donald W. Parsons', 'raw_affiliation_strings': ['Baylor College of Medicine, Houston, TX.'], 'affiliations': [{'raw_affiliation_string': 'Baylor College of Medicine, Houston, TX.', 'institution_ids': ['https://openalex.org/I181547552']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.46039, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 66, 'max': 73}, 'biblio': {'volume': '74', 'issue': '23_Supplement', 'first_page': '11', 'last_page': '11'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11642', 'display_name': 'Genomics and Rare Diseases', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11642', 'display_name': 'Genomics and Rare Diseases', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9798, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.951, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pediatric-cancer', 'display_name': 'Pediatric cancer', 'score': 0.51061183}, {'id': 'https://openalex.org/keywords/exome', 'display_name': 'Exome', 'score': 0.4863568}], 'concepts': [{'id': 'https://openalex.org/C16671776', 'wikidata': 'https://www.wikidata.org/wiki/Q5420592', 'display_name': 'Exome sequencing', 'level': 4, 'score': 0.73478055}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.6863097}, {'id': 'https://openalex.org/C109825262', 'wikidata': 'https://www.wikidata.org/wiki/Q1139164', 'display_name': 'Germline', 'level': 3, 'score': 0.5493823}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.54799515}, {'id': 'https://openalex.org/C2993561819', 'wikidata': 'https://www.wikidata.org/wiki/Q5097977', 'display_name': 'Pediatric cancer', 'level': 3, 'score': 0.51061183}, {'id': 'https://openalex.org/C534262118', 'wikidata': 'https://www.wikidata.org/wiki/Q177719', 'display_name': 'Medical diagnosis', 'level': 2, 'score': 0.4880637}, {'id': 'https://openalex.org/C10590036', 'wikidata': 'https://www.wikidata.org/wiki/Q417664', 'display_name': 'Exome', 'level': 5, 'score': 0.4863568}, {'id': 'https://openalex.org/C80227256', 'wikidata': 'https://www.wikidata.org/wiki/Q1124169', 'display_name': 'Genetic counseling', 'level': 2, 'score': 0.46689427}, {'id': 'https://openalex.org/C24432333', 'wikidata': 'https://www.wikidata.org/wiki/Q2068526', 'display_name': 'Whole genome sequencing', 'level': 4, 'score': 0.4303491}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.3850282}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36307263}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.28021228}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.27817944}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.26580012}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19886777}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.1558775}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.114735484}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.cansusc14-11', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.43, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4367844067', 'https://openalex.org/W3083501552', 'https://openalex.org/W3024198590', 'https://openalex.org/W2772505697', 'https://openalex.org/W2484239316', 'https://openalex.org/W2400191746', 'https://openalex.org/W2094815267', 'https://openalex.org/W2093932542', 'https://openalex.org/W2043256480', 'https://openalex.org/W1983406990'], 'abstract_inverted_index': {'Abstract': [0], 'Advances': [1], 'in': [2, 88, 121, 165, 186, 232, 241, 252, 304, 312, 331, 347, 359, 374, 402], 'sequencing': [3, 29, 58, 504], 'technologies': [4], 'allow': [5], 'for': [6, 16, 153, 177, 432], 'provision': [7], 'of': [8, 27, 34, 51, 63, 79, 97, 155, 158, 190, 207, 257, 277, 298, 343, 356, 377, 409, 420, 428, 434, 505, 516, 523], 'genome-scale': [9], 'data': [10, 393, 424], 'to': [11, 46, 136, 174, 197, 227, 323], 'oncologists': [12, 170, 429], 'and': [13, 54, 82, 105, 119, 134, 141, 151, 163, 169, 215, 282, 293, 307, 314, 334, 352, 381, 425, 430, 498, 510, 530], 'geneticists': [14], 'caring': [15], 'pediatric': [17, 349, 379, 508], 'cancer': [18, 243, 308, 403, 495], 'patients': [19, 202, 237, 260, 269, 313, 410], 'but': [20], 'current': [21], 'experience': [22], 'with': [23, 65, 211, 217, 238, 270, 286], 'the': [24, 35, 48, 61, 89, 100, 130, 156, 167, 183, 274, 341, 348, 391, 421, 426, 517, 524], 'clinical': [25, 49, 324, 418], 'application': [26], 'genomic': [28], 'is': [30, 45, 386], 'limited.': [31], 'The': [32, 199, 221, 337, 417], 'goal': [33], 'BASIC3': [36, 338, 518], '(Baylor': [37], 'Advancing': [38], 'Sequencing': [39], 'into': [40, 60, 129], 'Childhood': [41], 'Cancer': [42, 73, 528, 531, 544], 'Care)': [43], 'study': [44, 184, 284, 339], 'determine': [47, 175], 'impact': [50], 'incorporating': [52], 'tumor': [53, 84, 383, 512], 'constitutional': [55], 'whole': [56, 502], 'exome': [57, 503], '(WES)': [59], 'care': [62], 'children': [64], 'newly': [66], 'diagnosed': [67, 507], 'solid': [68, 380, 509], 'tumors': [69, 213, 219], 'at': [70, 94], 'Texas': [71], "Children's": [72], 'Center': [74], '(target': [75], 'enrollment': [76], 'n=280).': [77], 'WES': [78, 110, 159, 223, 346, 361, 392, 423], 'patient': [80, 285], 'blood': [81, 123], 'frozen': [83], 'samples': [85, 124], 'was': [86], 'conducted': [87], 'CLIA-certified': [90], 'Whole': [91], 'Genome': [92], 'Laboratory': [93], 'Baylor': [95], 'College': [96], 'Medicine': [98], 'using': [99], 'vCrome': [101], '2.1': [102], 'capture': [103], 'platform': [104, 118], 'Illumina': [106], 'paired-end': [107], 'sequencing.': [108], 'Reported': [109], 'germline': [111, 222, 345, 422], 'findings': [112, 231, 321, 500], 'were': [113, 267], 'validated': [114], 'by': [115, 138, 441], 'a': [116, 142, 204, 353, 387], 'second': [117], 'evaluated': [120], 'parental': [122, 357], 'if': [125], 'available,': [126], 'then': [127], 'deposited': [128], 'electronic': [131], 'medical': [132, 280], 'record': [133], 'disclosed': [135], 'families': [137, 194, 306], 'their': [139], 'oncologist': [140], 'genetic': [143, 262, 275], 'counselor.': [144], 'These': [145], 'disclosure': [146], 'visits': [147], 'are': [148, 171, 437], 'audio': [149], 'recorded': [150], 'transcribed': [152], 'analysis': [154, 394], 'communication': [157], 'results': [160, 224, 364, 436, 515], 'between': [161], 'parents': [162, 168, 431], 'oncologists;': [164], 'addition,': [166], 'serially': [172], 'interviewed': [173], 'preferences': [176, 427], 'reporting': [178, 433], 'this': [179], 'complex': [180], 'information.': [181], 'Since': [182], 'opened': [185], 'August': [187], '2012,': [188], '80%': [189], '145': [191], 'potentially': [192], 'eligible': [193], 'have': [195, 326], 'consented': [196], 'enrollment.': [198], 'first': [200], '100': [201], 'comprise': [203], 'diverse': [205], 'representation': [206], 'diagnoses,': [208], 'including': [209, 235], '32': [210], 'CNS': [212], '(32%)': [214], '68': [216], 'non-CNS': [218], '(68%).': [220], '(n=85': [225], 'reported': [226], 'date)': [228], 'included': [229], 'diagnostic': [230], '10': [233], 'cases': [234], '7': [236, 259], 'pathogenic': [239], 'mutations': [240, 250, 271, 287, 370, 415, 497], 'dominant': [242], 'susceptibility': [244, 369, 404, 496], 'genes': [245, 333], '(all': [246], 'singletons': [247], 'except': [248], 'TP53': [249], 'identified': [251, 273, 373], '2': [253, 268], 'patients).': [254], 'Only': [255], '3': [256], 'these': [258, 435], 'had': [261, 411], 'testing': [263, 297], 'recommended': [264], 'clinically.': [265], 'There': [266], 'which': [272, 288], 'cause': [276], 'other': [278], '(non-cancer)': [279], 'problems,': [281], '1': [283], 'explained': [289], 'both': [290], 'liver': [291], 'disease': [292], 'hepatocellular': [294], 'carcinoma.': [295], 'Downstream': [296], 'at-risk': [299], 'relatives': [300], 'has': [301], 'occurred': [302], 'rapidly': [303], 'several': [305], 'screening': [309], 'recommendations': [310], 'implemented': [311], 'family': [315], 'members.': [316], 'Seven': [317], 'medically': [318, 413], 'actionable': [319, 414], 'incidental': [320, 412, 499], 'unrelated': [322], 'phenotype': [325], 'also': [327], 'been': [328], 'reported,': [329], 'predominantly': [330], 'cardiovascular': [332], 'mitochondrial': [335], 'DNA.': [336], 'demonstrates': [340], 'feasibility': [342], 'routine': [344], 'oncology': [350], 'clinic': [351], 'significant': [354], 'level': [355], 'interest': [358], 'receiving': [360], 'results.': [362], 'Early': [363, 514], 'suggest': [365], 'that': [366], 'clinically': [367], 'relevant': [368], 'can': [371], 'be': [372], 'approximately': [375], '10%': [376], 'unselected': [378], 'brain': [382, 511], 'patients.': [384], 'This': [385], 'conservative': [388], 'estimate,': [389], 'as': [390], 'does': [395], 'not': [396], 'currently': [397], 'report': [398], 'copy': [399], 'number': [400], 'variation': [401], 'genes.': [405], 'A': [406], 'similar': [407], 'proportion': [408], 'reported.': [416], 'utility': [419], 'under': [438], 'study.': [439, 519], 'Supported': [440], 'NHGRI/NCI': [442], '1U01HG006485.': [443], 'Citation': [444], 'Format:': [445], 'Sharon': [446], 'E.': [447], 'Plon,': [448], 'Sarah': [449], 'Scollon,': [450], 'Katie': [451], 'Bergstrom,': [452], 'Robin': [453], 'A.': [454, 489], 'Kerstein,': [455], 'Murali': [456], 'Chintagumpala,': [457], 'Stacey': [458], 'L.': [459, 475], 'Berg,': [460], 'Susan': [461], 'G.': [462, 478], 'Hilsenbeck,': [463], 'Tao': [464], 'Wang,': [465], 'Surya': [466], 'Rednam,': [467], 'David': [468], 'Wheeler,': [469], 'Laurence': [470], 'McCullough,': [471], 'Richard': [472, 488], 'Street,': [473], 'Amy': [474], 'McGuire,': [476], 'Reid': [477], 'Jeffrey,': [479], 'Donna': [480], 'M.': [481, 484], 'Muzny,': [482], 'Christine': [483], 'Eng,': [485], 'Yaping': [486], 'Yang,': [487], 'Gibbs,': [490], 'Donald': [491], 'W.': [492], 'Parsons.': [493], 'Evaluating': [494], 'from': [501], 'sequentially': [506], 'patients:': [513], '[abstract].': [520], 'In:': [521], 'Proceedings': [522], 'AACR': [525], 'Special': [526], 'Conference:': [527], 'Susceptibility': [529, 532], 'Syndromes;': [533], 'Jan': [534], '29-Feb': [535], '1,': [536], '2014;': [537], 'San': [538], 'Diego,': [539], 'CA.': [540], 'Philadelphia': [541], '(PA):': [542], 'AACR;': [543], 'Res': [545], '2014;74(23': [546], 'Suppl):Abstract': [547], 'nr': [548], '11.': [549], 'doi:10.1158/1538-7445.CANSUSC14-11': [550]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995568947', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-12-24T15:45:29.400462', 'created_date': '2016-06-24'}