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[112], 'variants.': [113], 'The': [114], 'mechanisms': [115], 'catalytic': [117], 'improvement': [118], 'both': [120, 153], 'mutation': [121], 'type': [122], 'dependent.': [125], '3-FBA': [128, 141], 'via': [130, 136, 143, 148], 'kcat,': [131], 'but': [132], 'reduced': [133], '4-FBA': [134, 146], 'KM.': [137], 'Conversely,': [138], 'S385Y/T': [139], 'kcat.': [149], 'This': [150, 185], 'suggested': [151], 'that': [152], 'proximity': [155], 'orientation': [158], 'are': [159], 'very': [160], 'sensitive': [161], 'mutation.': [163], 'Comparison': [164], 'variant': [167], 'each': [170], 'indicated': [172], 'different': [173, 194], 'binding': [174], 'modes': [175], 'three': [178], 'substrates,': [180], 'supported': [181], 'computational': [183], 'docking.': [184], 'highlights': [186], 'divergence': [189], 'evolution': [192], 'specificities,': [196], 'implications': [198], 'enzyme': [200], 'engineering.': [201]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995509510', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2024-09-08T19:38:46.651761', 'created_date': '2016-06-24'}