Publication Information

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231, 618, 956, 1034, 1091, 1197, 1252, 1298, 1803, 2151, 2445, 2739, 2754, 2960, 3135], 'such': [141, 1176, 1184, 1713, 2793, 2813, 2830, 2967], 'as': [142, 541, 543, 1063, 1080, 1185, 1275, 1496, 1615, 1688, 1714, 2103, 2794, 2814, 2831, 2878, 2968, 3226], 'involucrin,': [143, 2232], 'loricrin,': [144, 253], 'small': [145, 616, 1186], 'proline-rich': [146, 617, 1187, 3474], 'proteins,': [147, 2910], 'XP5/LCEs,': [148], 'cystatin': [149], 'A,': [150, 841, 1109, 1485, 1675, 1986, 2299, 2331, 2802, 3003, 3032, 3157, 3442], 'elafin,': [151], 'S100': [153, 1090, 1097, 1297, 1323], 'family': [154, 796, 1247, 1268, 1362, 2840, 3388], 'members': [155, 1436, 2923], 'that': [156, 751, 868, 954, 993, 1163, 1330, 1476, 1534, 1605, 1637, 1710, 1854, 1942, 2226, 2248, 2573, 2606, 2748, 2823, 3309, 3365, 3386, 3586, 3635], 'covalently': [158, 380, 2229], 'transglutaminases': [161], '(TGs)': [162], '1,': [163, 2126], '3,': [164], '5.': [166], 'precursor': [168, 1033, 1101, 1251, 2763, 3370], 'deposited': [171, 247], 'Nε': [173], '-(γ-glutamyl)': [174], 'lysine': [175], 'isodipeptide': [176, 515], 'formation': [177, 373, 499, 517, 600, 626, 1003, 1318, 3074, 3404, 3413], 'hierarchical': [180, 3081], 'fashion': [181], 'periphery,': [185], 'suggesting': [186, 1709], 'tight': [187, 2497, 2536, 2551, 2560, 2607], 'regulation': [188, 3069], 'TG': [190, 813], 'expression': [191, 674, 867], 'precursors.': [194], 'Desmosomes,': [195], 'mediate': [197], 'adhesion': [199, 413], 'transmit': [201, 3560], 'forces': [203], 'onto': [204, 242], 'filaments,': [207], 'initiation': [210, 3016, 3092, 3104], 'sites': [211], 'where': [215], 'involucrin': [216, 383, 606, 2187, 2259], 'molecules': [217, 1538], 'become': [218, 379, 619], 'first': [219, 505, 1026, 2083, 2201, 3301], 'plakins.': [222], 'During': [223, 612], 'this': [224, 267, 365, 949, 1245, 1599, 1703, 1727, 1855, 2749], 'phase': [225, 268, 3318], 'cross-linkage': [228, 519, 604, 886], 'desmosomal': [230, 888, 955, 1005, 2021, 2110], 'lipids,': [233], 'TG5': [234, 824, 866, 879, 902, 984, 994], 'may': [235, 304, 336, 880, 995, 1053, 1472, 1973, 2130, 2250, 3621], 'be': [236, 305, 337, 345, 881, 996, 1054, 1469, 1473, 1974, 2131, 2251, 2462, 2486, 2771, 2776, 3633], 'essential.': [237], 'provides': [239, 862, 1531, 2223], 'scaffold': [241, 625], 'other': [244, 1181], 'precursors': [245], 'increase': [249], 'mechanical': [250], 'strength,': [251], 'notably': [252], 'most': [255], 'abundant': [256], 'insoluble': [258], 'protein.': [260, 1132, 3484], 'TG1': [261, 273, 696, 746, 2249, 3433], 'enzyme': [265], 'cross-linkage,': [271], 'deficit': [274], 'associated': [276, 1751, 2372, 2532, 2600, 2656], 'disappearance': [279], 'electron-dense': [282], 'ultrastructure.': [284], 'In': [285, 987, 1325, 2236, 2412, 2586, 3337, 3359, 3378, 3420, 3490, 3605], 'parallel,': [286], 'bilayer': [289], 'replaced': [295], 'ceramids': [297, 2257], 'secreted': [298, 1725, 2717, 2738, 2753, 2777], 'from': [299, 352, 511, 603, 1115, 1392, 2508, 3333, 3628], 'lamellar': [300, 653, 710, 1624, 1683, 2374, 2467], 'granules': [301, 1684], '(LGs),': [302], 'related': [306, 1474], 'peroxisomes.': [308], 'LGs': [309, 335, 393], 'fuse': [310], 'granular': [313, 329], 'layer': [314, 330, 874, 1650], 'extrude': [320], 'contents': [322, 3618], 'into': [323, 331, 1553, 2066], 'space,': [326], 'secretory': [332, 367, 1672, 2796], 'cells.': [333], 'Alternatively,': [334], 'an': [338, 613, 951, 1747, 2879, 3018], 'artifact': [339], 'conventional': [341], 'electron': [342], 'microscopy': [343, 1500, 1514], 'part': [346, 1661], 'continuous': [349, 1665], 'extending': [351], 'trans-golgi': [354, 1639], 'network': [355], 'At': [360], 'any': [361], 'rate,': [362], 'LG': [363], 'or': [364, 985, 1210, 2124, 2137, 2790], 'tubular': [366], 'desquamation.': [375, 1785], 'Secreted': [376], 'bound': [381, 2148, 2230], 'side': [387], 'CE.': [390, 503, 533], 'Besides': [391], 'ceramids,': [392], 'enzymes,': [395], 'inhibitors,': [397], 'some': [399, 2911], 'substrates': [402], '(e.g.': [403], 'corneodesmosin),': [404], 'crucial': [407, 2500, 2577], 'tightening': [409], 'subsequent': [415], 'desquamation,': [416], 'respectively.': [417], 'Kalinin': [418], 'A': [419, 422, 815, 1011, 1287, 2176, 3002, 3086, 3278], 'E,': [420, 444, 837, 920, 1111, 2389, 2620], 'Kajava': [421], 'V,': [423, 3437], 'Steinert': [424, 558, 2143, 2173, 2241], 'P': [425, 559, 1104, 1108, 1872, 2010, 2017, 2144, 2174, 3182, 3185, 3446], 'M.': [426, 2145, 2175], 'Epithelial': [427], 'function:': [429], 'assembly': [430, 530, 566], 'structural': [432, 529, 758, 2150], 'features': [433], 'envelope.': [438, 1230, 2159], 'Bioessays': [439], '2002:': [440, 857, 2323, 2514, 2641], '24:': [441], '789–800.': [442], 'Candi': [443, 836], 'Schmidt': [445], 'R,': [446, 1402, 1870, 2847, 3035, 3193], 'Melino': [447], 'G.': [448, 1740], 'envelope:': [451], 'model': [453, 3339], 'death': [456], 'skin.': [459, 1394, 1506, 3175], 'Nat': [460, 1018, 2000, 2057, 3176, 3264], 'Rev': [461], 'Mol': [462, 577, 2321, 2353, 2379, 2861, 2891, 3212], 'Cell': [463, 579, 938, 1134, 1888, 2512], 'Biol': [464, 578, 681, 801, 939, 1135, 1396, 1757, 1787, 1889, 2161, 2513, 2639], '2005:': [465, 1371, 1426, 1510, 2059, 2409, 3292], '6:': [466], '328–340.': [467], 'Dai': [468], 'X,': [469], 'Segre': [470, 3155], 'J': [471, 680, 800, 854, 937, 1133, 1302, 1368, 1395, 1423, 1507, 1691, 1737, 1756, 1786, 1815, 1887, 2160, 2288, 2406, 2511, 2638, 3034, 3156, 3192, 3449, 3486], 'A.': [472, 2018], 'Transcriptional': [473], 'control': [474, 554, 3142], 'specification': [477], 'differentiation.': [479, 936, 1422, 1850, 2435, 2744], 'Curr': [480], 'Opin': [481], 'Genet': [482, 1019, 2001, 2058, 2290, 2322, 2354, 2380, 2408, 2862, 2892, 3177, 3265], 'Dev': [483, 2031, 3023], '2004:': [484, 1305, 1694, 1818, 2032, 2355, 2540, 2694, 2720, 3024, 3487], '14:': [485], '485–491.': [486], 'three': [488], 'reviews': [489, 507, 1310], 'provide': [490, 688, 2064], 'excellent': [491, 2416], 'overview': [492], 'information': [493, 864], 'various': [495], 'aspects': [496, 510], 'article': [506, 585, 861, 1309, 1704, 1894, 3302, 3493, 3529], 'basic': [508, 1749], 'biochemical': [509, 2205], 'identification': [513, 775, 1027, 2076], 'bond': [516, 2190], 'TGs': [521], 'details': [523], 'molecular': [526, 2417, 3013], 'composition': [527], 'second': [535, 1070, 2238, 2588, 3380, 3528], 'review': [536], 'integrates': [537], 'more': [538], 'recent': [539], 'developments': [540], 'well': [542, 714, 1064, 2821], 'human': [544, 782, 852, 1354, 1505, 1745, 1779, 2154, 2613, 2690, 2734], 'diseases': [545], 'while': [546], 'last': [548], 'concentrated': [550], 'transcriptional': [553, 3139, 3374], 'assembly.': [557], 'M,': [560, 641, 660, 916, 1219, 1288, 1290, 1343, 1377, 1379, 1406, 1677, 1679, 1731, 1733, 1735, 1763, 1767, 1797, 2489, 2491, 3188], 'Marekov': [561, 2140, 2168], 'L': [562, 2141, 2169, 3436], 'N.': [563], 'Initiation': [564], 'stratified': [574, 2684], 'squamous': [575], 'epithelia.': [576], '1999:': [580, 2197, 3178], '10:': [581, 2864], '4247–4261.': [582], 'sets': [586], 'basis': [588], 'mechanistic': [591], 'understanding': [592], 'serial': [595], 'events': [596], 'leading': [597, 2947], 'starting': [601], 'out': [602], 'envoplakin': [608], 'periplakin': [610], 'molecules.': [611], 'elongation': [614], 'phase,': [615], 'attached,': [620], 'leads': [622, 1914, 3255], 'along': [627], 'entire': [629, 1073], 'periphery.': [631], 'Ultimately,': [632], 'reinforcement': [633], 'occurs': [634, 869], 'primarily': [635, 1264], 'deposition': [637], 'loricrin.': [639, 1174], 'Huber': [640, 659, 1342, 1405], 'Rettler': [642], 'I,': [643, 2623, 2998], 'Bernasconi': [644], 'K,': [645, 768, 1868, 2493, 2649, 3248], 'et': [646, 665, 842, 921, 1112, 1348, 1680, 1768, 1798, 1874, 1987, 2041, 2269, 2300, 2332, 2364, 2392, 2494, 2523, 2650, 2673, 2848, 2873, 3036, 3251, 3276, 3471], 'al.': [647, 666, 843, 922, 1113, 1349, 1681, 1769, 1799, 1875, 1988, 2042, 2270, 2301, 2333, 2365, 2393, 2495, 2524, 2651, 2674, 2849, 2874, 3037, 3252, 3277, 3472], 'Mutations': [648, 1989, 2271, 2334, 2366, 2394, 2850], 'keratinocyte': [650, 678], 'transglutaminase': [651, 773, 778, 790, 798, 846, 2180], 'ichthyosis.': [654, 2351, 2404, 2473], 'Science': [655, 3291, 3460], '1995:': [656], '267:': [657], '525–528.': [658], 'Yee': [661], 'VC,': [662], 'Burri': [663], 'N,': [664, 1292, 1347, 1765, 1795, 2142, 2170, 2702, 3246, 3275], 'Consequences': [667], 'seven': [669], 'novel': [670, 794, 1194, 1385, 1435, 1520, 2177, 2629, 2654, 2677, 2750, 2898, 3506], 'mutations': [671, 2079, 2527, 2591], 'transglutaminase.': [679], 'Chem': [682, 802, 1397, 1758, 1788, 2162, 2640], '1997:': [683, 1759, 3065, 3214], '272:': [684, 1760], '21018–21026.': [685], 'articles': [687, 1430, 1822, 2725, 3218, 3515], 'knowledge': [690], 'structure–function': [693], 'relationship': [694, 1783], 'vivo': [698, 3573], 'vitro.': [701], 'There': [702], 'spectrum': [705], 'clinical': [707, 2421, 2884], 'phenotypes': [708], 'ichthyosis,': [711], 'correlates': [713], 'enzymatic': [716, 2448], 'activity': [717], 'differentiating': [719], 'vitro': [722, 3570], 'altered': [724], 'three-dimensional': [727], 'modeling': [728], 'based': [729], 'crystal': [732], 'factor': [735, 3046, 3166, 3308], 'XIIIa.': [736], 'Furthermore,': [737, 2818], 'important': [738, 997, 1055, 1335, 2611, 3296, 3401], 'amino': [739, 1048, 1456], 'acids': [740], 'central': [743], 'core': [744], 'identified': [748, 819, 1274, 2438, 2593], 'show': [750, 927, 1178], 'sequences': [755, 1043, 1460, 3313], 'influence': [756], 'functional': [760, 1451, 3242], 'integrity': [761, 3288], 'TG1.': [763], 'Grenard': [764], 'P,': [765, 2036, 2386, 2522, 2698, 2700], 'Bates': [766], 'M': [767, 1215, 2625, 2704, 2997, 3439], 'Aeschlimann': [769], 'D.': [770, 1010, 1408, 3151], 'Evolution': [771], 'genes:': [774], 'gene': [779, 788, 795, 1361, 1440, 2275, 2339, 2526, 2655, 2687, 2853], 'cluster': [780, 817, 1201, 2712, 2730, 2899], 'chromosome': [783, 821, 1040, 1258, 2318, 2341, 2691, 2735, 2756, 2905], '15q15.': [784], 'Structure': [785], 'encoding': [789, 1992, 2276, 2716, 2737, 2854], 'X': [791, 3028], 'member,': [797], 'Z.': [799], '2001:': [803, 940, 1236, 1398, 1789, 2291, 2863, 3461], '276:': [804, 1399, 1790], '33066–33078.': [805], 'ultimate': [809, 2224], 'status': [810], 'vertebrate': [812], 'genes.': [814], 'new': [816, 1246, 1411, 1585, 2278, 2338, 2345, 2683], '15q': [822], 'including': [823], '7': [826, 1839], 'genes': [827, 1037, 1087, 1203, 1256, 1273, 2437, 2715, 2732, 2901, 3371], 'detailed': [831, 1242, 1904, 2475], 'genomic': [832, 1059], 'analysis': [833, 1905, 3363, 3452], 'presented.': [835], 'Oddi': [838], 'S,': [839, 1982, 2361, 2518, 2645, 3000, 3183, 3190, 3465], 'Paradisi': [840], 'Expression': [844, 3038], '5': [847, 1832], 'normal': [849], 'pathologic': [851], 'epidermis.': [853, 877, 1301, 2555, 2614], 'Invest': [855, 1303, 1369, 1424, 1508, 1692, 1816], 'Dermatol': [856, 1304, 1370, 1425, 1509, 1693, 1817], '119:': [858], '670–677.': [859], 'helpful': [863], 'already': [870], 'spinous': [873], 'Thus,': [878, 1970, 3583], 'responsible': [882, 2252, 2463, 3410], 'initial': [885, 999, 1142], 'at': [887, 1004, 1046, 1154, 1454], 'plaques.': [889, 1006], 'observations': [891], 'could': [892], 'explain': [893], 'particular': [895], 'phenotype': [896, 969, 2885], 'caused': [897, 1881], 'lack': [900, 981, 1172, 2100], 'acral': [905], 'type': [906, 2376, 2809, 3042], 'Peeling': [908, 973], 'Skin': [909, 974], 'Syndrome': [910], '(I.': [911], 'Mclean,': [912], 'personal': [913, 3153], 'communication).': [914, 3154], 'Chidgey': [915], 'Brakebusch': [917], 'C,': [918, 1008, 1793, 1984, 2038, 2040, 2264, 2297, 2327, 2359, 2870, 3159], 'Gustafsson': [919], 'Mice': [923], 'lacking': [924], 'desmocollin': [925], '1': [926, 2052], 'fragility': [929], 'accompanied': [930], 'defects': [933], 'abnormal': [935, 2119], '155:': [941], '821–832.': [942], 'Along': [943, 1697], 'same': [945, 1629, 1664, 1699, 3138], 'lines': [946, 1700], 'thinking,': [948, 1702], 'elegant': [952], 'demonstration': [953], 'also': [958, 1086, 1334, 1545, 1603, 1635, 1953, 1965, 2470, 3611], 'barrier.': [963, 1528, 2585, 3236], 'Desmocollin': [964], '1-knockout': [965], 'mice': [966, 1148, 1900, 2044, 2092, 2135, 2571, 3055, 3203, 3427], 'have': [967, 1149, 1633, 3615, 3622], 'somewhat': [970], 'resembling': [971, 1570], 'Syndrome,': [975], 'due': [978, 2097, 2132, 3259], 'either': [983, 2122], 'LEKTI.': [986], 'combination,': [988], 'these': [989, 1631, 2574, 2724, 2959], 'results': [990, 1940, 1945, 2115], 'indirectly': [991], 'suggest': [992], 'stages': [1000, 1315, 1847], 'Backendorf': [1007], 'Hohl': [1009, 1407, 2012], 'common': [1012], 'origin': [1013], 'proteins?': [1017], '1992:': [1020], '2:': [1021], '91.': [1022], 'sequence': [1029, 1262, 2759], 'homologies': [1030], 'between': [1031, 1593, 1651, 2935], 'encoded': [1035, 1198, 1254], 'located': [1038, 3326], '1q21.': [1041], 'Homologous': [1042], 'found': [1045, 1966], 'carboxy': [1050], 'terminus,': [1051], 'bridging.': [1057], 'conserved': [1062, 2711, 2729, 2928], 'two': [1066, 1805], 'exons': [1067], 'containing': [1071], 'ORF.': [1074], 'locus': [1076], 'now': [1078], 'known': [1079, 2774, 2822], '‘epidermal': [1081], 'differentiation': [1082, 1207, 1366, 1777, 2631, 3106], 'complex’': [1083], 'includes': [1085], 'coding': [1088], '‘fused': [1093, 1415], 'genes’': [1094], 'composed': [1095], 'domains': [1098, 1453], 'sequences.': [1102], 'Koch': [1103, 2009], 'J,': [1105, 1216, 1487, 1738, 2011, 2843, 3006, 3029, 3250, 3273], 'de': [1106, 2858, 2888, 2977], 'Viragh': [1107], 'Scharer': [1110], 'Lessons': [1114], 'loricrin-deficient': [1116], 'mice:': [1117], 'compensatory': [1118, 1167], 'mechanisms': [1119], 'maintaining': [1120], 'skin': [1121, 2401], 'function': [1123, 1586, 1922, 2178, 2549, 2768, 3172, 3507], 'absence': [1126], 'major': [1129, 1547], '2000:': [1136, 2002, 2664], '151:': [1137], '389–400.': [1138], 'Much': [1139], 'surprise': [1143], 'investigators,': [1146], 'loricrin-knockout': [1147, 1281], 'only': [1150, 1947, 2465, 3400, 3608], 'slight': [1152], 'erythema': [1153], 'birth': [1155], 'develop': [1157], 'normally': [1158], 'later': [1159], 'on.': [1160], 'suggests': [1162], 'there': [1164], 'exists': [1165], 'mechanism': [1168], 'backup': [1170, 1277], 'Indeed,': [1175, 3110], 'animals': [1177], 'upregulation': [1179, 3535], 'components': [1183], 'protein': [1188, 1387, 1596, 2279, 2483, 2686, 2798, 3475], '2': [1189, 3319], '(SPRR2),': [1190], 'repetin,': [1191, 1355, 1443], 'subgroup': [1195], 'within': [1204, 1535], '(XP5': [1209], 'LCEs).': [1211], 'Marshall': [1212], 'D,': [1213, 1294, 1717, 2008, 2013], 'Hardman': [1214], 'Nield': [1217], 'K': [1218], 'Byrne': [1220], 'C.': [1221, 2707], 'Differentially': [1222], 'expressed': [1223, 1419, 2740, 2915, 3394], 'late': [1224, 1249, 1846, 2742], 'constituents': [1225], 'Proc': [1231, 2192, 3060], 'Natl': [1232, 2193, 3061], 'Acad': [1233, 2194, 3062], 'Sci': [1234, 2195, 3063], 'USA': [1235, 2196, 3064], '98:': [1237], '13031–13036.': [1238], 'description': [1243], '(LCEs)': [1253], '1q21': [1259], 'showing': [1261], 'similarities': [1263, 2760], 'SPRRs.': [1266], 'corresponds': [1269], 'mouse': [1272, 1393], 'system': [1278], 'mice.': [1282, 2029, 2510, 3290, 3555], 'Eckert': [1283], 'R': [1284, 2869], 'L,': [1285, 2172, 2520, 2872, 3444], 'Broome': [1286], 'Ruse': [1289], 'Robinson': [1291], 'Ryan': [1293], 'Lee': [1295], 'K.': [1296], '123:': [1306], '23–33.': [1307], 'studies': [1311, 2063, 2209, 2546], 'concentrating': [1312], 'early': [1314], 'role': [1321, 3125], 'proteins.': [1324, 1483, 2718, 2764], 'meantime,': [1327], 'we': [1328], 'know': [1329], 'S100A7': [1331], '(psoriasin)': [1332], 'innate': [1337], 'defense': [1338], 'gram-negative': [1340], 'bacteria.': [1341], 'Siegenthaler': [1344], 'G,': [1345, 3447, 3470], 'Mirancea': [1346], 'Isolation': [1350], 'characterization': [1352, 1771, 2212], 'member': [1357, 1412], 'fused': [1360, 1439, 1482], 'complex.': [1367], '124:': [1372, 1427, 1511], '998–1007.': [1373], 'Makino': [1374], 'T,': [1375, 2006, 2617, 2668], 'Takaishi': [1376], 'Morohashi': [1378], 'Huh': [1380], 'N': [1381], 'H.': [1382], 'Hornerin,': [1383], 'profilaggrin-like': [1386], 'differentiation-specific': [1389], 'marker': [1390, 2632], 'isolated': [1391], '47445–47452.': [1400], 'Contzler': [1401], 'Favre': [1403], 'B,': [1404, 2329, 2845, 3271], 'Cornulin,': [1409], 'gene’': [1416], 'family,': [1417, 1441, 1811], '990–997.': [1428], 'report': [1432, 2726], 'several': [1434, 2838, 3080, 3366], 'i.e.': [1442], 'hornerin,': [1444], 'cornulin,': [1446], 'all': [1447], 'possess': [1450], 'Ca++-binding': [1452], 'terminus': [1457], 'repetitive': [1459], 'middle.': [1463], 'Their': [1464], 'exact': [1465], 'functions': [1466, 2449, 2476], 'remain': [1467, 2484], 'elucidated': [1470], 'but': [1471, 1952, 2469, 2965, 3408, 3610], 'profilaggrin,': [1478], 'prototype': [1480], 'Al-Amoudi': [1484], 'Dubochet': [1486], 'Norlen': [1488], 'L.': [1489], 'Nanostructure': [1490], 'extracellular': [1494], 'space': [1495, 1646], 'observed': [1497, 2117], 'cryo-electron': [1499], 'vitreous': [1502, 1516], 'sections': [1503, 1517], '764–777.': [1512], 'Cryo-electron': [1513], 'reveals': [1518, 2093, 3364], 'exciting': [1519], 'data': [1521], 'Notably,': [1529], 'it': [1530, 1601, 2819, 3584], 'definite': [1532], 'proof': [1533, 2225, 2605], 'desmosomes,': [1536], 'cadherin': [1537, 1574], 'straight': [1540], 'regularly': [1542], 'spaced.': [1543], 'describes': [1546], 'changes': [1548], 'desmosomes': [1551], 'up': [1552], 'uppermost': [1555], 'transition': [1563], 'state': [1564], 'final': [1567], 'much': [1569, 2420], 'arrangement': [1572], 'ecto-domains': [1575], 'recently': [1576], 'proposed': [1577, 1636, 1853], 'Garrod.': [1579], 'study': [1581, 2202], 'points': [1582], 'cadherins': [1588], 'involving': [1589], 'direct': [1591, 3373], 'interaction': [1592], 'domains.': [1597], 'From': [1598], 'study,': [1600], 'evident': [1604], 'apparently': [1606], 'closed': [1607], 'linear': [1608], 'structures': [1609, 1964, 2575], 'cannot': [1610], 'represent': [1611, 1670], 'flattened': [1612], 'vesicles': [1614], 'described': [1616], 'Landman': [1618], 'thought': [1620], 'correspond': [1622], 'disks.': [1626], 'Using': [1627], 'technique,': [1630], 'authors': [1632], 'previously': [1634], 'network,': [1640], 'LGs,': [1642], 'transitional': [1649], 'granulosum': [1654], 'thus': [1669, 3620], 'apparatus.': [1673], 'Ishida-Yamamoto': [1674], 'Simon': [1676, 1730, 1762], 'Kishibe': [1678], 'Epidermal': [1682, 2019], 'transport': [1685], 'different': [1686, 1711], 'cargoes': [1687], 'distinct': [1689, 2932], 'aggregates.': [1690], '122:': [1695, 1819], '1137–1144.': [1696], 'reports': [1705, 2203, 3530], 'immunoelectron': [1706], 'microscopic': [1707], 'findings': [1708, 1897], 'cargos': [1712], 'glucosylceramides,': [1715], 'cathepsin': [1716], 'corneodesmosin,': [1718, 1746], 'kallikreins': [1720], 'individually': [1722], 'sequentially': [1724], 'structure.': [1729], 'Montezin': [1732], 'Guerrin': [1734, 1766], 'Durieux': [1736], 'Serre': [1739], 'Characterization': [1741], 'purification': [1743], 'glycoprotein': [1750], 'corneocyte-specific': [1753], 'modified': [1754], 'desmosomes.': [1755], '31770–31776.': [1761], 'Jonca': [1764, 1794], 'Refined': [1770], 'corneodesmosin': [1773, 1829, 2026, 2123], 'proteolysis': [1774, 2218], 'epidermis': [1780, 2564, 2918, 3052, 3397], 'its': [1782, 1907, 3124], '20292–20299.': [1791], 'Caubet': [1792], 'Brattsand': [1796], 'Degradation': [1800], 'corneodesmosome': [1802], 'serine': [1806, 1994, 2789], 'proteases': [1807], 'kallikrein': [1810, 1831, 1838], 'SCTE/KLK5/hK5': [1812], 'SCCE/KLK7/hK7.': [1814], '1235–1244.': [1820], 'describe': [1823], 'cleavage': [1827], '(stratum': [1833, 1840], 'tryptic': [1835, 1843], 'enzyme)': [1836, 1844], 'chymo': [1842], 'process': [1856], 'precisely': [1859], 'controlled': [1860], 'protease': [1863, 1995, 2055, 2095], 'inhibitor': [1865, 2808], 'balance.': [1866], 'List': [1867], 'Szabo': [1869], 'Wertz': [1871, 3184], 'W,': [1873, 3186], 'Loss': [1876], 'proteolytically': [1878], 'processed': [1879], 'filaggrin': [1880], 'deletion': [1884, 1911, 3349], 'Matriptase/MT-SP1.': [1886], '2003:': [1890, 2381, 2893, 3266], '163:': [1891], '901–910.': [1892], 'extends': [1895], 'previous': [1896], 'matriptase-knockout': [1899], 'presents': [1902], 'phenotype.': [1909], 'Targeted': [1910], 'matriptase': [1913, 1943, 1972], 'loss': [1917], 'regulating': [1924], 'key': [1925, 3593], 'steps': [1926], 'maturation': [1930], '(i.e.': [1931], 'formation,': [1934], 'morphogenesis,': [1936], 'desquamation).': [1938], 'Earlier': [1939], 'revealed': [1941], 'deficiency': [1944], 'not': [1946, 2464, 3399, 3607], 'disturbed': [1949], 'function,': [1951], 'thymus': [1955], 'hair': [1957], 'follicle': [1958], 'defects,': [1959], 'combination': [1961], 'involved': [1963], "Netherton's": [1968, 2072], 'disease.': [1969, 2538], 'speculatively': [1971], 'target': [1976], 'LEKTI': [1978, 2102], '(see': [1979], 'below).': [1980], 'Chavanas': [1981], 'Bodemer': [1983], 'Rochat': [1985], 'SPINK5,': [1991], 'inhibitor,': [1996, 2799], 'cause': [1997, 2068, 2105], 'Netherton': [1998, 2046], 'syndrome.': [1999, 2286], '25:': [2003], '141–142.': [2004], 'Yang': [2005], 'Liang': [2007], 'Kheradmand': [2014], 'F,': [2015, 2266, 2268, 2295, 2363, 2647, 2670, 2867], 'Overbeek': [2016], 'detachment,': [2020], 'dissociation,': [2022], 'destabilization': [2024], 'Spink5–/–': [2028], 'Genes': [2030, 3022], '18:': [2033, 3025], '2354–2358.': [2034], 'Descargues': [2035], 'Deraison': [2037], 'Bonnart': [2039], 'Spink5-deficient': [2043], 'mimic': [2045], 'syndrome': [2047], 'degradation': [2049, 2120], 'desmoglein': [2051, 2125], 'hyperactivity.': [2056], '37:': [2060], '56–65.': [2061], 'insight': [2065], 'pathogenesis': [2070], 'disease': [2073, 2089, 2402], 'SPINK5': [2078], 'reported': [2080], 'article.': [2084], 'reproduction': [2086], 'transgenic': [2091, 3054, 3202], 'hyperactivity': [2096], 'detachment': [2108], 'dissociation.': [2111], 'However,': [2112, 2569, 2765], 'partly': [2113, 2920], 'conflicting': [2114], 'repectively.': [2127], 'differences': [2129], 'strains': [2136], 'antibodies': [2138], 'used.': [2139], 'Ceramides': [2146], 'foreskin': [2155], '1998:': [2163], '273:': [2164], '17763–17770.': [2165], 'Nemes': [2166], 'Z,': [2167], 'Fesus': [2171], '1:': [2181], 'attachment': [2182, 2255], 'long-chain': [2184], 'omega-hydroxyceramides': [2185], 'ester': [2189], 'formation.': [2191, 2262, 3299], '96:': [2198], '8402–8407.': [2199], 'tantalizing': [2204], 'mass': [2207], 'spectrometric': [2208], 'lipopeptides': [2214], 'recovered': [2215], 'after': [2216, 3644], 'partial': [2217], 'purified': [2220], 'CEs.': [2221], 'ceramides': [2227], 'periplakin,': [2233], 'envoplakin.': [2235], 'article,': [2239, 2589, 3381], 'Peter': [2240], 'his': [2243], 'group': [2244, 2751], 'provided': [2245], 'experimental': [2246, 3362], 'evidence': [2247, 2422, 3383], 'ester-bound': [2261], 'Lefevre': [2263, 2296, 2326, 2358], 'Jobard': [2265, 2294, 2362], 'Caux': [2267], 'CGI-58,': [2273, 2478], 'esterase/lipase/thioesterase': [2282], 'subfamily,': [2283], 'Chanarin-Dorfman': [2285], 'Am': [2287, 2405], 'Hum': [2289, 2320, 2352, 2378, 2407, 2860, 2890], '69:': [2292], '1002–1012.': [2293], 'Karaduman': [2298, 2330], 'Lipoxygenase-3': [2302], '(ALOXE3)': [2303], '12': [2305], '(R)-lipoxygenase': [2306], '(ALOX12B)': [2307], 'mutated': [2309, 2974], 'non-bullous': [2311], 'congenital': [2312, 2350, 2400, 2442], 'ichthyosiform': [2313], 'erythroderma': [2314], '(NCIE)': [2315], 'linked': [2316], '17p13.1.': [2319], '11:': [2324, 3215], '107–113.': [2325], 'Bouadjar': [2328, 2844], 'ichthyin': [2336], '5q33': [2342], 'form': [2346], 'autosomal': [2348, 2440], 'recessive': [2349, 2441], '13:': [2356], '2473–2482.': [2357], 'Audebert': [2360], 'transporter': [2369, 2458], 'ABCA12': [2370, 2396, 2457, 2482], 'ichthyosis': [2375, 2443, 2468, 2599], '2.': [2377], '12:': [2382, 2894], '2369–2378.': [2383], 'Kelsell': [2384], 'D': [2385, 3008, 3031, 3195], 'Norgett': [2387], 'E': [2388], 'Unsworth': [2390], 'H,': [2391, 2705, 3440, 3467], 'underlie': [2397], 'severe': [2399], 'harlequin': [2403], '76:': [2410], '794–803.': [2411], 'series': [2414], 'genetic': [2418], 'studies,': [2419], 'has': [2423, 2565, 2758, 3240, 3510], 'accumulated': [2424], 'complexity': [2427], 'importance': [2429], 'metabolism': [2432], 'Some': [2436], 'involve': [2444], 'ill-defined': [2447], 'metabolism.': [2453], 'Very': [2454], 'recently,': [2455], 'was': [2459, 2980, 3549], 'shown': [2460, 2981], 'Harlequin': [2472], 'lipoxygenases,': [2479], 'ichthyn,': [2480], 'clarified.': [2487, 2772], 'Furuse': [2488, 2492], 'Hata': [2490], 'Claudin-based': [2496], 'junctions': [2498, 2552, 2561, 2608], 'mammalian': [2503], 'barrier:': [2505], 'lesson': [2507], 'claudin-1-deficient': [2509, 2570], '156:': [2515], '1099–1111.': [2516], 'Hadj-Rabia': [2517], 'Baala': [2519], 'Vabres': [2521], 'Claudin-1': [2525], 'neonatal': [2529, 2602], 'sclerosing': [2530], 'cholangitis': [2531], 'ichthyosis:': [2534], 'junction': [2537], 'Gastroenterology': [2539], '127:': [2541], '1386–1390.': [2542], 'superb': [2545], 'revealing': [2547], 'Previously,': [2556], 'existence': [2558], 'been': [2566, 3511], 'largely': [2567], 'neglected.': [2568], 'reveal': [2572, 3519], 'maintenance': [2580, 3231], 'claudin-1': [2590], 'rare': [2596], 'variant': [2597], 'cholangitis,': [2603], 'providing': [2604], 'equally': [2610, 3409], 'Park': [2615], 'G': [2616], 'Lim': [2618], 'S': [2619, 2622, 3270], 'Jang': [2621], 'Morasso': [2624], 'I.': [2626, 3450], 'Suprabasin,': [2627], 'potential': [2634, 3624], 'precursor.': [2637], '277:': [2642], '45195–45202.': [2643], 'Oomizu': [2644], 'Sahuc': [2646], 'Asahina': [2648], 'Kdap,': [2652], 'stratification': [2659, 3020, 3095], 'epithelium.': [2662], 'Gene': [2663, 2719], '256:': [2665], '19–27.': [2666], 'Matsui': [2667], 'Hayashi-Kisumi': [2669], 'Kinoshita': [2671], 'Y,': [2672], 'Identification': [2675, 2708, 2875], 'keratinocyte-secreted': [2678], 'peptides': [2679, 2812], 'dermokine-alpha/-beta': [2680], 'epithelium-secreted': [2685], '19q13.1.': [2692], 'Genomics': [2693], '84:': [2695], '384–397.': [2696], 'Moffatt': [2697], 'Salois': [2699], 'St-Amant': [2701], 'Gaumond': [2703], 'Lanctot': [2706], 'skin-specific': [2714], '334:': [2721], '123–131.': [2722], 'Together,': [2723], '19q13': [2736], 'intriguing': [2747], '19': [2757], 'precise': [2767], 'remains': [2769], 'Proteins': [2773], 'rapidly': [2781], 'growing': [2782], 'number': [2784], 'include': [2786], 'inhibitors': [2787], 'cysteine': [2791, 2937, 3617], 'proteinases,': [2792], 'SKALP/elafin,': [2795], 'leukocyte': [2797], 'LEKTI,': [2800], 'cystatine': [2801], 'M/E,': [2804], 'plasminogen': [2806], 'activator': [2807], '2,': [2810], 'antimicrobial': [2811], 'defensins': [2815], 'cathelicidins.': [2817], 'secrete': [2825], 'cytokines': [2826], 'growth': [2828, 3045, 3058, 3101], 'factors': [2829, 3227, 3393, 3425], 'IL-1,': [2832], 'IL-6,': [2833], 'IL-18,': [2834], 'TNF-α,': [2835], 'TGF-β,': [2836], 'FGF': [2839], 'members.': [2841], 'Fischer': [2842], 'Heilig': [2846], 'SLURP-1': [2855, 2877, 2972], 'Mal': [2857, 2887, 2976], 'Meleda.': [2859, 2889], '875–880.': [2865], 'Chimienti': [2866], 'Hogg': [2868], 'Plantard': [2871], 'neuromodulator': [2881], 'explains': [2882], '3017–3024.': [2895], 'Similarly,': [2896, 3526], 'localized': [2903], '8q24': [2906], 'encodes': [2908], 'LY-6/PLAUR': [2909, 2922], 'secreted.': [2921, 2971], 'characterized': [2925], 'disulfide-bonding': [2933], 'pattern': [2934], '10': [2936], 'residues': [2938], 'presence': [2941], 'consensus': [2944], 'motif': [2945], 'CCX4C': [2946], 'three-finger': [2950], 'folding': [2951], 'snake': [2954], 'toxin-like': [2955], 'form.': [2956], 'Most': [2957], 'glycosyl': [2962], 'phosphatidylinositol': [2963], 'anchored,': [2964], 'few,': [2966], 'SLURP-1,': [2969], 'Meleda': [2978], 'modulate': [2983], 'acetylcholine': [2984], '(Ach)': [2985], 'responses': [2986], 'frog': [2988], 'eggs': [2989], 'transfected': [2990], 'Ach': [2993], 'Receptor': [2994], 'a7.': [2995], 'Koster': [2996], 'Kim': [2999], 'Mills': [3001], 'DeMayo': [3004], 'F': [3005], 'Roop': [3007, 3194], 'R.': [3009, 3196], 'p63': [3010, 3116], 'switch': [3014, 3088], 'epithelial': [3019, 3094], 'program.': [3021], '126–131.': [3026], 'Wang': [3027], 'Greenhalgh': [3030], 'Bickenbach': [3033, 3191], 'dominant-negative': [3041], 'II': [3043], 'transforming': [3044], 'beta': [3047], '(TGF-beta)': [3048], 'receptor': [3049, 3558], 'blocks': [3056], 'TGF-beta-mediated': [3057], 'inhibition.': [3059], '94:': [3066], '2386–2391.': [3067], 'involves': [3079], 'levels': [3082], 'signal': [3084], 'transmission.': [3085], 'master': [3087], 'required': [3089, 3099, 3167], 'p63.': [3097], 'Also': [3098], 'inhibition': [3102], 'TGF-β/Activin/Smad': [3108], 'signaling.': [3109], 'both': [3111, 3568], 'pathways': [3112, 3559], 'appear': [3113], 'cooperate:': [3115], 'regulates': [3117], 'IKK-α': [3119, 3130], 'promoter,': [3120], 'independent': [3122], 'NF-κB': [3128], 'pathway,': [3129], 'acts': [3131], 'Smad2/3': [3134], 'Mad': [3143], 'transcription': [3144, 3165, 3307, 3392, 3424], 'counteract': [3146], 'Myc': [3147], '(M.': [3148], 'Karin': [3149], 'Roop,': [3152], 'Bauer': [3158], 'Fuchs': [3160], 'E.': [3161], 'Klf4': [3162, 3220], 'establishing': [3169], '22:': [3179], '356–360.': [3180], 'Attar': [3181], 'McArthur': [3187], 'Imakado': [3189], 'Inhibition': [3197], 'retinoid': [3199, 3222], 'signaling': [3200], 'alters': [3204], 'processing': [3206], 'disrupts': [3208], 'function.': [3211], 'Endocrinol': [3213], '792–800.': [3216], 'establish': [3219], 'acid': [3223], 'nuclear': [3224], 'receptors': [3225], 'SPRR2': [3238], 'promoter': [3239], 'Klf4-binding': [3243], 'site.': [3244], 'Wakabayashi': [3245, 3249], 'Itoh': [3247], 'Keap1-null': [3253], 'mutation': [3254], 'postnatal': [3257], 'lethality': [3258], 'constitutive': [3261], 'Nrf2': [3262, 3332, 3342], 'activation.': [3263], '35:': [3267], '238–245.': [3268], 'Ting': [3269], 'Caddy': [3272], 'Hislop': [3274], 'homolog': [3279], 'Drosophila': [3281], 'grainy': [3282, 3390, 3422], 'head': [3283, 3391], '308:': [3293], '411–413.': [3294], 'Machinery': [3295], 'deals': [3303], 'Nrf2,': [3305], 'binds': [3310], 'ARE': [3312], 'detoxifying': [3320], 'deoxidating': [3322], 'reactions.': [3323], 'Keap1': [3324], 'cytoplasm': [3329], 'retains': [3331], 'entering': [3334], 'nucleus.': [3336], 'presented,': [3340], 'pathway': [3343], 'constitutively': [3345], 'activated': [3346], 'Keap1,': [3351], 'resulting': [3352], 'lethal': [3354], 'massive': [3356], 'esophageal': [3357], 'hyperkeratosis.': [3358], 'silico,': [3360], 'targets': [3375], 'Nrf2.': [3377], 'convincing': [3382], 'presented': [3385], 'fly': [3396, 3406], 'cuticle': [3407], 'proper': [3412], 'vertebrates.': [3419], 'fact,': [3421, 3606], 'head-like': [3423], 'drive': [3428], 'directly': [3429, 3601], 'transcriptionally': [3431], 'gene.': [3434], 'Hooper': [3435], 'Wong': [3438], 'Thelin': [3441], 'Hansson': [3443], 'Falk': [3445], 'Gordon': [3448], 'Molecular': [3451], 'commensal': [3454], 'host-microbial': [3455], 'relationships': [3456], 'intestine.': [3459], '291:': [3462], '881–884.': [3463], 'Pradervand': [3464], 'Yasukawa': [3466], 'Muller': [3468], 'O': [3469], 'Small': [3473], '1A': [3476], 'gp130': [3479, 3557], 'pathway-': [3480], 'stress-inducible': [3482], 'cardioprotective': [3483, 3562], 'EMBO': [3485], '23:': [3488], '4517–4525.': [3489], 'break-trough': [3492], 'reporting': [3494], 'profiling': [3496], 'laser-captured': [3498], 'intestinal': [3499], 'epithelia': [3500], 'exposed': [3501], 'bacteria,': [3503], 'surprising': [3505], 'SPRR2A': [3509], 'identified.': [3512], 'Several': [3513], 'follow-up': [3514], 'diverse': [3517, 3524], 'tissues': [3518], 'rapid': [3520], 'SPRR': [3521], 'induction': [3522], 'following': [3523, 3589], 'insults.': [3525], 'SPRR1A': [3532, 3546, 3577], '2A': [3534, 3548], 'response': [3537], 'biomechanical/ischemic': [3539], 'stress': [3540, 3588], 'heart.': [3543], 'Upregulation': [3544], 'markedly': [3550], 'reduced': [3551], 'gp130-knockout': [3554], 'effects': [3563], 'IL-6': [3565], 'cytokines.': [3566], 'Excitingly,': [3567], 'ectopic': [3574], 'overexpression': [3575], 'protected': [3578], 'cardiomyocytes': [3579], 'ischemic': [3581], 'appears': [3585], 'oxidative': [3587, 3603, 3629], 'wounding': [3590], 'trigger': [3594], 'SRRR': [3596], 'expression,': [3597], 'itself': [3600], 'counteracts': [3602], 'stress.': [3604, 3630], 'SPRRs': [3609, 3636], 'LCEs': [3612], 'loricrin': [3614], 'high': [3616], 'scavenging': [3623], 'protect': [3626], 'us': [3627], 'should': [3632], 'remembered': [3634], 'were': [3637], 'cloned': [3638], '20': [3639], 'years': [3640], 'ago': [3641], 'subtraction': [3643], 'exposure': [3645], 'UV': [3649], 'light.': [3650]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995436601', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T09:05:36.707313', 'created_date': '2016-06-24'}