Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1995350077', 'doi': 'https://doi.org/10.1523/jneurosci.3381-14.2015', 'title': 'MuSK Frizzled-Like Domain Is Critical for Mammalian Neuromuscular Junction Formation and Maintenance', 'display_name': 'MuSK Frizzled-Like Domain Is Critical for Mammalian Neuromuscular Junction Formation and Maintenance', 'publication_year': 2015, 'publication_date': '2015-03-25', 'ids': {'openalex': 'https://openalex.org/W1995350077', 'doi': 'https://doi.org/10.1523/jneurosci.3381-14.2015', 'mag': '1995350077', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25810523', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6705368'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3381-14.2015', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/35/12/4926.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.jneurosci.org/content/jneuro/35/12/4926.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057826850', 'display_name': 'Julien Messéant', 'orcid': 'https://orcid.org/0000-0002-0254-9545'}, 'institutions': [{'id': 'https://openalex.org/I4210113260', 'display_name': 'Centre de Neurophysique Physiologie et Pathologie', 'ror': 'https://ror.org/026pjf520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210113260']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Julien Messéant', 'raw_affiliation_strings': ['UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)'], 'affiliations': [{'raw_affiliation_string': 'UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)', 'institution_ids': ['https://openalex.org/I4210113260']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078565959', 'display_name': 'Alexandre Dobbertin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113260', 'display_name': 'Centre de Neurophysique Physiologie et Pathologie', 'ror': 'https://ror.org/026pjf520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210113260']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alexandre Dobbertin', 'raw_affiliation_strings': ['UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)'], 'affiliations': [{'raw_affiliation_string': 'UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)', 'institution_ids': ['https://openalex.org/I4210113260']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051298126', 'display_name': 'Emmanuelle Girard', 'orcid': 'https://orcid.org/0000-0001-6730-9596'}, 'institutions': [{'id': 'https://openalex.org/I100532134', 'display_name': 'Université Claude Bernard Lyon 1', 'ror': 'https://ror.org/029brtt94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I203339264']}, {'id': 'https://openalex.org/I4210100775', 'display_name': 'Laboratoire de Biologie Moléculaire de la Cellule', 'ror': 'https://ror.org/01bj4fd12', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210100596', 'https://openalex.org/I4210100775', 'https://openalex.org/I86767153']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Emmanuelle Girard', 'raw_affiliation_strings': ["LBMC - Laboratoire de Biologie Moléculaire de la Cellule (46 allée d'Italie 69364 Lyon Cedex 07 - France)"], 'affiliations': [{'raw_affiliation_string': "LBMC - Laboratoire de Biologie Moléculaire de la Cellule (46 allée d'Italie 69364 Lyon Cedex 07 - France)", 'institution_ids': ['https://openalex.org/I100532134', 'https://openalex.org/I4210100775']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037913230', 'display_name': 'Perrine Delers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210113260', 'display_name': 'Centre de Neurophysique Physiologie et Pathologie', 'ror': 'https://ror.org/026pjf520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210113260']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Perrine Delers', 'raw_affiliation_strings': ['UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)'], 'affiliations': [{'raw_affiliation_string': 'UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)', 'institution_ids': ['https://openalex.org/I4210113260']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057110029', 'display_name': 'Marin Manuel', 'orcid': 'https://orcid.org/0000-0002-5344-3572'}, 'institutions': [{'id': 'https://openalex.org/I4210113260', 'display_name': 'Centre de Neurophysique Physiologie et Pathologie', 'ror': 'https://ror.org/026pjf520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210113260']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Marin Manuel', 'raw_affiliation_strings': ['UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)'], 'affiliations': [{'raw_affiliation_string': 'UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)', 'institution_ids': ['https://openalex.org/I4210113260']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026646798', 'display_name': 'Francesca Mangione', 'orcid': 'https://orcid.org/0000-0002-3288-8644'}, 'institutions': [{'id': 'https://openalex.org/I4210092671', 'display_name': 'Laboratory Orofacial Pathologies, Imaging and Biotherapies', 'ror': 'https://ror.org/00kneq391', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I204730241', 'https://openalex.org/I4210092671']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Francesca Mangione', 'raw_affiliation_strings': ['EA 2496 - Pathologies, Imagerie et Biothérapies oro-faciales (UFR Odontologie \r\n1 rue Maurice Arnoux \r\n92120 Montrouge France - France)'], 'affiliations': [{'raw_affiliation_string': 'EA 2496 - Pathologies, Imagerie et Biothérapies oro-faciales (UFR Odontologie \r\n1 rue Maurice Arnoux \r\n92120 Montrouge France - France)', 'institution_ids': ['https://openalex.org/I4210092671']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027231771', 'display_name': 'Alain Schmitt', 'orcid': 'https://orcid.org/0000-0002-3565-8692'}, 'institutions': [{'id': 'https://openalex.org/I4210141964', 'display_name': 'Institut Cochin', 'ror': 'https://ror.org/051sk4035', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I154526488', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210141964']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alain Schmitt', 'raw_affiliation_strings': ['IC UM3 (UMR 8104 / U1016) - Institut Cochin (22 rue Méchain, 75014 Paris - France)'], 'affiliations': [{'raw_affiliation_string': 'IC UM3 (UMR 8104 / U1016) - Institut Cochin (22 rue Méchain, 75014 Paris - France)', 'institution_ids': ['https://openalex.org/I4210141964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089782168', 'display_name': 'Dominique Le Denmat', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210092671', 'display_name': 'Laboratory Orofacial Pathologies, Imaging and Biotherapies', 'ror': 'https://ror.org/00kneq391', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I204730241', 'https://openalex.org/I4210092671']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Dominique Le Denmat', 'raw_affiliation_strings': ['EA 2496 - Pathologies, Imagerie et Biothérapies oro-faciales (UFR Odontologie \r\n1 rue Maurice Arnoux \r\n92120 Montrouge France - France)'], 'affiliations': [{'raw_affiliation_string': 'EA 2496 - Pathologies, Imagerie et Biothérapies oro-faciales (UFR Odontologie \r\n1 rue Maurice Arnoux \r\n92120 Montrouge France - France)', 'institution_ids': ['https://openalex.org/I4210092671']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041762507', 'display_name': 'Jordi Molgó', 'orcid': 'https://orcid.org/0000-0002-0693-8994'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I4210086740', 'display_name': 'Institut des Neurosciences Paris-Saclay', 'ror': 'https://ror.org/002v40q27', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I4210086740']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Jordi Molgó', 'raw_affiliation_strings': ['NeuroPSI - Institut des Neurosciences Paris-Saclay (Centre National de la Recherche Scientifique, Unité Mixte de Recherche-9197 Université Paris-Sud\r\nbâtiment 32 Campus de Recherche de Gif-sur-Yvette\r\n1, avenue de la Terrasse\r\n91198 Gif-sur-Yvette - France)'], 'affiliations': [{'raw_affiliation_string': 'NeuroPSI - Institut des Neurosciences Paris-Saclay (Centre National de la Recherche Scientifique, Unité Mixte de Recherche-9197 Université Paris-Sud\r\nbâtiment 32 Campus de Recherche de Gif-sur-Yvette\r\n1, avenue de la Terrasse\r\n91198 Gif-sur-Yvette - France)', 'institution_ids': ['https://openalex.org/I102197404', 'https://openalex.org/I4210086740']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051927570', 'display_name': 'Daniel Zytnicki', 'orcid': 'https://orcid.org/0000-0002-0431-9604'}, 'institutions': [{'id': 'https://openalex.org/I4210113260', 'display_name': 'Centre de Neurophysique Physiologie et Pathologie', 'ror': 'https://ror.org/026pjf520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210113260']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Daniel Zytnicki', 'raw_affiliation_strings': ['NPSM - Neurophysique et physiologie du système moteur (45 Rue des Saints-Pères 75270 PARIS CEDEX 06 - France)', 'UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)'], 'affiliations': [{'raw_affiliation_string': 'UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)', 'institution_ids': ['https://openalex.org/I4210113260']}, {'raw_affiliation_string': 'NPSM - Neurophysique et physiologie du système moteur (45 Rue des Saints-Pères 75270 PARIS CEDEX 06 - France)', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040562294', 'display_name': 'Laurent Schaeffer', 'orcid': 'https://orcid.org/0000-0001-6600-503X'}, 'institutions': [{'id': 'https://openalex.org/I100532134', 'display_name': 'Université Claude Bernard Lyon 1', 'ror': 'https://ror.org/029brtt94', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I203339264']}, {'id': 'https://openalex.org/I4210100775', 'display_name': 'Laboratoire de Biologie Moléculaire de la Cellule', 'ror': 'https://ror.org/01bj4fd12', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I100532134', 'https://openalex.org/I113428412', 'https://openalex.org/I1294671590', 'https://openalex.org/I203339264', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210100596', 'https://openalex.org/I4210100775', 'https://openalex.org/I86767153']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Laurent Schaeffer', 'raw_affiliation_strings': ["LBMC - Laboratoire de Biologie Moléculaire de la Cellule (46 allée d'Italie 69364 Lyon Cedex 07 - France)"], 'affiliations': [{'raw_affiliation_string': "LBMC - Laboratoire de Biologie Moléculaire de la Cellule (46 allée d'Italie 69364 Lyon Cedex 07 - France)", 'institution_ids': ['https://openalex.org/I100532134', 'https://openalex.org/I4210100775']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047977001', 'display_name': 'Claire Legay', 'orcid': 'https://orcid.org/0000-0003-0263-9257'}, 'institutions': [{'id': 'https://openalex.org/I4210113260', 'display_name': 'Centre de Neurophysique Physiologie et Pathologie', 'ror': 'https://ror.org/026pjf520', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I204730241', 'https://openalex.org/I4210096427', 'https://openalex.org/I4210113260']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Claire Legay', 'raw_affiliation_strings': ['UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)'], 'affiliations': [{'raw_affiliation_string': 'UMR 8119 - Centre de neurophysique, physiologie, pathologie (45 Rue des Saints-Pères \r\n75270 PARIS CEDEX 06 - France)', 'institution_ids': ['https://openalex.org/I4210113260']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5041522364', 'display_name': 'Laure Strochlic', 'orcid': 'https://orcid.org/0000-0001-5373-4284'}, 'institutions': [], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Laure Strochlic', 'raw_affiliation_strings': ['U686 - Biologie des Jonctions Neuromusculaires Normales et Pathologiques (Centre Universitaire Des Saints Pères\r\n45, Rue Des Saints Pères\r\n75270 PARIS CEDEX 06 - France)'], 'affiliations': [{'raw_affiliation_string': 'U686 - Biologie des Jonctions Neuromusculaires Normales et Pathologiques (Centre Universitaire Des Saints Pères\r\n45, Rue Des Saints Pères\r\n75270 PARIS CEDEX 06 - France)', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.669, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 64, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '35', 'issue': '12', 'first_page': '4926', 'last_page': '4941'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10441', 'display_name': 'Molecular Mechanisms of Muscle Regeneration and Atrophy', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10441', 'display_name': 'Molecular Mechanisms of Muscle Regeneration and Atrophy', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11271', 'display_name': 'Myasthenia Gravis and Thymic Tumors Research', 'score': 0.9966, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12400', 'display_name': 'Gene Therapy for Spinal Muscular Atrophy', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neuromuscular-junction', 'display_name': 'Neuromuscular Junction', 'score': 0.591804}, {'id': 'https://openalex.org/keywords/musk-antibodies', 'display_name': 'MuSK Antibodies', 'score': 0.513288}], 'concepts': [{'id': 'https://openalex.org/C2777240379', 'wikidata': 'https://www.wikidata.org/wiki/Q776995', 'display_name': 'Neuromuscular junction', 'level': 2, 'score': 0.85300386}, {'id': 'https://openalex.org/C107300179', 'wikidata': 'https://www.wikidata.org/wiki/Q41797887', 'display_name': 'Frizzled', 'level': 4, 'score': 0.7748878}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6631589}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5605874}, {'id': 'https://openalex.org/C137620995', 'wikidata': 'https://www.wikidata.org/wiki/Q155769', 'display_name': 'Wnt signaling pathway', 'level': 3, 'score': 0.47928637}, {'id': 'https://openalex.org/C127445978', 'wikidata': 'https://www.wikidata.org/wiki/Q187181', 'display_name': 'Synapse', 'level': 2, 'score': 0.43238777}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.42276925}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.40274215}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.38528386}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.33619654}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15050417}], 'mesh': [{'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D018908', 'descriptor_name': 'Muscle Weakness', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000110', 'descriptor_name': 'Acetylcholinesterase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000110', 'descriptor_name': 'Acetylcholinesterase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005221', 'descriptor_name': 'Fatigue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005221', 'descriptor_name': 'Fatigue', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D005221', 'descriptor_name': 'Fatigue', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006023', 'descriptor_name': 'Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018737', 'descriptor_name': 'Hand Strength', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018737', 'descriptor_name': 'Hand Strength', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047908', 'descriptor_name': 'Intracellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018021', 'descriptor_name': 'Lithium Chloride', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D018021', 'descriptor_name': 'Lithium Chloride', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D018021', 'descriptor_name': 'Lithium Chloride', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009046', 'descriptor_name': 'Motor Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018908', 'descriptor_name': 'Muscle Weakness', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D018908', 'descriptor_name': 'Muscle Weakness', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018908', 'descriptor_name': 'Muscle Weakness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020294', 'descriptor_name': 'Myasthenic Syndromes, Congenital', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D020294', 'descriptor_name': 'Myasthenic Syndromes, Congenital', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D020294', 'descriptor_name': 'Myasthenic Syndromes, Congenital', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020294', 'descriptor_name': 'Myasthenic Syndromes, Congenital', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009469', 'descriptor_name': 'Neuromuscular Junction', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061251', 'descriptor_name': 'Primary Cell Culture', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011950', 'descriptor_name': 'Receptors, Cholinergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3381-14.2015', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/35/12/4926.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://hal.archives-ouvertes.fr/hal-01165625', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://hal.science/hal-01165625', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6705368', 'pdf_url': 'https://europepmc.org/articles/pmc6705368?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705368', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25810523', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1523/jneurosci.3381-14.2015', 'pdf_url': 'https://www.jneurosci.org/content/jneuro/35/12/4926.full.pdf', 'source': {'id': 'https://openalex.org/S5555990', 'display_name': 'Journal of Neuroscience', 'issn_l': '0270-6474', 'issn': ['0270-6474', '1529-2401'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319739', 'host_organization_name': 'Society for Neuroscience', 'host_organization_lineage': ['https://openalex.org/P4310319739'], 'host_organization_lineage_names': ['Society for Neuroscience'], 'type': 'journal'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.54, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1512382989', 'https://openalex.org/W1528084578', 'https://openalex.org/W1541691555', 'https://openalex.org/W1605791286', 'https://openalex.org/W1716978847', 'https://openalex.org/W1904864670', 'https://openalex.org/W1977655066', 'https://openalex.org/W1979993283', 'https://openalex.org/W1980294445', 'https://openalex.org/W1984522719', 'https://openalex.org/W1987686381', 'https://openalex.org/W1991623532', 'https://openalex.org/W1995479176', 'https://openalex.org/W2001282076', 'https://openalex.org/W2001765460', 'https://openalex.org/W2002094130', 'https://openalex.org/W2013293426', 'https://openalex.org/W2026340991', 'https://openalex.org/W2027276122', 'https://openalex.org/W2032193793', 'https://openalex.org/W2038477534', 'https://openalex.org/W2045933247', 'https://openalex.org/W2046728125', 'https://openalex.org/W2051788298', 'https://openalex.org/W2058851119', 'https://openalex.org/W2063791205', 'https://openalex.org/W2064642287', 'https://openalex.org/W2066335707', 'https://openalex.org/W2066700864', 'https://openalex.org/W2068946266', 'https://openalex.org/W2069952320', 'https://openalex.org/W2077951355', 'https://openalex.org/W2078734091', 'https://openalex.org/W2081457831', 'https://openalex.org/W2088189541', 'https://openalex.org/W2092210127', 'https://openalex.org/W2093074098', 'https://openalex.org/W2095238537', 'https://openalex.org/W2096371662', 'https://openalex.org/W2108512667', 'https://openalex.org/W2123125411', 'https://openalex.org/W2124733101', 'https://openalex.org/W2127693756', 'https://openalex.org/W2128686747', 'https://openalex.org/W2136470556', 'https://openalex.org/W2139050516', 'https://openalex.org/W2143061420', 'https://openalex.org/W2143528835', 'https://openalex.org/W2144696840', 'https://openalex.org/W2144807735', 'https://openalex.org/W2144864783', 'https://openalex.org/W2146781077', 'https://openalex.org/W2148646540', 'https://openalex.org/W2154042683', 'https://openalex.org/W2164681071', 'https://openalex.org/W2167831873', 'https://openalex.org/W2394858412'], 'related_works': ['https://openalex.org/W4207033132', 'https://openalex.org/W2081949986', 'https://openalex.org/W2080509277', 'https://openalex.org/W2051803999', 'https://openalex.org/W2018448892', 'https://openalex.org/W2017632960', 'https://openalex.org/W2006555393', 'https://openalex.org/W1972875962', 'https://openalex.org/W1964589725', 'https://openalex.org/W17572718'], 'abstract_inverted_index': {'The': [0], 'muscle-specific': [1], 'kinase': [2], 'MuSK': [3, 15, 30, 76, 182], 'is': [4, 184], 'one': [5], 'of': [6, 29, 41, 56, 75, 82, 89, 106, 119, 140, 146, 168], 'the': [7, 18, 39, 53, 72, 86, 134, 137, 147, 166], 'key': [8], 'molecules': [9], 'orchestrating': [10], 'neuromuscular': [11, 44, 169], 'junction': [12], '(NMJ)': [13], 'formation.': [14], 'interacts': [16], 'with': [17, 38, 96], 'Wnt': [19], 'morphogens,': [20], 'through': [21], 'its': [22], 'Frizzled-like': [23], 'domain': [24, 26], '(cysteine-rich': [25], '[CRD]).': [27], 'Dysfunction': [28], 'CRD': [31, 73, 183], 'in': [32, 59, 77, 100, 155, 194, 197], 'patients': [33], 'has': [34], 'been': [35], 'recently': [36], 'associated': [37, 95], 'onset': [40], 'myasthenia,': [42, 121], 'common': [43], 'disorders': [45, 170], 'mainly': [46], 'characterized': [47], 'by': [48], 'fatigable': [49], 'muscle': [50, 84, 126], 'weakness.': [51], 'However,': [52], 'physiological': [54], 'role': [55, 193], 'Wnt-MuSK': [57, 173], 'interaction': [58], 'NMJ': [60, 90, 153, 187, 195], 'formation': [61, 188], 'and': [62, 92, 103, 128, 158, 189], 'function': [63], 'remains': [64], 'to': [65, 172], 'be': [66], 'elucidated.': [67], 'Here,': [68], 'we': [69], 'demonstrate': [70], 'that': [71, 109, 151, 181], 'deletion': [74], 'mice': [78, 116, 157], 'caused': [79], 'profound': [80], 'defects': [81, 154], 'both': [83], 'prepatterning,': [85], 'first': [87, 135], 'step': [88], 'formation,': [91], 'synapse': [93], 'differentiation': [94], 'a': [97, 143, 161], 'drastic': [98], 'deficit': [99], 'AChR': [101, 111], 'clusters': [102], 'excessive': [104], 'growth': [105], 'motor': [107], 'axons': [108], 'bypass': [110], 'clusters.': [112], 'Moreover,': [113], 'adult': [114], 'MuSKΔCRD': [115, 156], 'developed': [117], 'signs': [118], 'congenital': [120], 'including': [122], 'severe': [123], 'NMJs': [124], 'dismantlement,': [125], 'weakness,': [127], 'fatigability.': [129], 'We': [130], 'also': [131], 'report,': [132], 'for': [133, 165, 186], 'time,': [136], 'beneficial': [138], 'effects': [139], 'lithium': [141], 'chloride,': [142], 'reversible': [144], 'inhibitor': [145], 'glycogen': [148], 'synthase': [149], 'kinase-3,': [150], 'rescued': [152], 'therefore': [159], 'constitutes': [160], 'novel': [162], 'therapeutic': [163], 'reagent': [164], 'treatment': [167], 'linked': [171], 'signaling': [174], 'pathway': [175], 'deficiency.': [176], 'Together,': [177], 'our': [178], 'data': [179], 'reveal': [180], 'critical': [185], 'plays': [190], 'an': [191], 'unsuspected': [192], 'maintenance': [196], 'adulthood.': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995350077', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 3}], 'updated_date': '2024-09-09T02:32:57.537007', 'created_date': '2016-06-24'}