Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1995257796', 'doi': 'https://doi.org/10.3109/07853890.2011.653392', 'title': 'Current treatments and strategies for type 2 diabetes: Can we do better with GLP-1 receptor agonists?', 'display_name': 'Current treatments and strategies for type 2 diabetes: Can we do better with GLP-1 receptor agonists?', 'publication_year': 2012, 'publication_date': '2012-04-25', 'ids': {'openalex': 'https://openalex.org/W1995257796', 'doi': 'https://doi.org/10.3109/07853890.2011.653392', 'mag': '1995257796', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22530845'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/07853890.2011.653392', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203391715', 'display_name': 'Annals of Medicine', 'issn_l': '0785-3890', 'issn': ['0785-3890', '1365-2060'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320449', 'host_organization_name': 'Informa', 'host_organization_lineage': ['https://openalex.org/P4310320449'], 'host_organization_lineage_names': ['Informa'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5006038504', 'display_name': 'Gregory M. Peterson', 'orcid': 'https://orcid.org/0000-0002-6764-3882'}, 'institutions': [{'id': 'https://openalex.org/I94975175', 'display_name': 'Des Moines University', 'ror': 'https://ror.org/058w59113', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I94975175']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Gregory Peterson', 'raw_affiliation_strings': ['Mercy Center for Public Health Policy and Research, Des Moines University, 411 Laurel Street Suite A110, Des Moines, IA 50314, Des Moines University, 411 Laurel Street, Suite 3275, Des Moines, IA 50314, USA'], 'affiliations': [{'raw_affiliation_string': 'Mercy Center for Public Health Policy and Research, Des Moines University, 411 Laurel Street Suite A110, Des Moines, IA 50314, Des Moines University, 411 Laurel Street, Suite 3275, Des Moines, IA 50314, USA', 'institution_ids': ['https://openalex.org/I94975175']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5006038504'], 'corresponding_institution_ids': ['https://openalex.org/I94975175'], 'apc_list': {'value': 2085, 'currency': 'GBP', 'value_usd': 2557, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.344, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.235558, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '44', 'issue': '4', 'first_page': '338', 'last_page': '349'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9955, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.995, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sulfonylurea', 'display_name': 'Sulfonylurea', 'score': 0.6094656}, {'id': 'https://openalex.org/keywords/glycated-hemoglobin', 'display_name': 'Glycated hemoglobin', 'score': 0.5781905}, {'id': 'https://openalex.org/keywords/incretin', 'display_name': 'Incretin', 'score': 0.56821036}, {'id': 'https://openalex.org/keywords/thiazolidinedione', 'display_name': 'Thiazolidinedione', 'score': 0.42700163}], 'concepts': [{'id': 'https://openalex.org/C2780323712', 'wikidata': 'https://www.wikidata.org/wiki/Q19484', 'display_name': 'Metformin', 'level': 3, 'score': 0.8504214}, {'id': 'https://openalex.org/C2780533449', 'wikidata': 'https://www.wikidata.org/wiki/Q417762', 'display_name': 'Exenatide', 'level': 4, 'score': 0.8473074}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8324952}, {'id': 'https://openalex.org/C2781308992', 'wikidata': 'https://www.wikidata.org/wiki/Q2526479', 'display_name': 'Liraglutide', 'level': 4, 'score': 0.81781745}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.7245948}, {'id': 'https://openalex.org/C2780668416', 'wikidata': 'https://www.wikidata.org/wiki/Q202758', 'display_name': 'Hypoglycemia', 'level': 3, 'score': 0.66974354}, {'id': 'https://openalex.org/C2778854520', 'wikidata': 'https://www.wikidata.org/wiki/Q418776', 'display_name': 'Sulfonylurea', 'level': 3, 'score': 0.6094656}, {'id': 'https://openalex.org/C2777538456', 'wikidata': 'https://www.wikidata.org/wiki/Q311213', 'display_name': 'Glycated hemoglobin', 'level': 4, 'score': 0.5781905}, {'id': 'https://openalex.org/C2778881409', 'wikidata': 'https://www.wikidata.org/wiki/Q1420402', 'display_name': 'Incretin', 'level': 4, 'score': 0.56821036}, {'id': 'https://openalex.org/C185280430', 'wikidata': 'https://www.wikidata.org/wiki/Q14909910', 'display_name': 'Glucagon-like peptide 1 receptor', 'level': 4, 'score': 0.5377014}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48964506}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.46283033}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.42775175}, {'id': 'https://openalex.org/C2776923340', 'wikidata': 'https://www.wikidata.org/wiki/Q1393556', 'display_name': 'Thiazolidinedione', 'level': 4, 'score': 0.42700163}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.4268012}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.21790713}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.16189355}], 'mesh': [{'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D054795', 'descriptor_name': 'Incretins', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018027', 'descriptor_name': 'Receptors, Glucagon', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D014688', 'descriptor_name': 'Venoms', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D001786', 'descriptor_name': 'Blood Glucose', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003924', 'descriptor_name': 'Diabetes Mellitus, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000077270', 'descriptor_name': 'Exenatide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D052216', 'descriptor_name': 'Glucagon-Like Peptide 1', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D000067757', 'descriptor_name': 'Glucagon-Like Peptide-1 Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007003', 'descriptor_name': 'Hypoglycemia', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D007003', 'descriptor_name': 'Hypoglycemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054795', 'descriptor_name': 'Incretins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069450', 'descriptor_name': 'Liraglutide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018027', 'descriptor_name': 'Receptors, Glucagon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014688', 'descriptor_name': 'Venoms', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D014688', 'descriptor_name': 'Venoms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/07853890.2011.653392', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S203391715', 'display_name': 'Annals of Medicine', 'issn_l': '0785-3890', 'issn': ['0785-3890', '1365-2060'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320449', 'host_organization_name': 'Informa', 'host_organization_lineage': ['https://openalex.org/P4310320449'], 'host_organization_lineage_names': ['Informa'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22530845', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.8, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 74, 'referenced_works': ['https://openalex.org/W1559082056', 'https://openalex.org/W1590228841', 'https://openalex.org/W170829820', 'https://openalex.org/W1755903692', 'https://openalex.org/W1892323012', 'https://openalex.org/W1970638723', 'https://openalex.org/W1973349045', 'https://openalex.org/W1975588287', 'https://openalex.org/W1975591028', 'https://openalex.org/W1977102586', 'https://openalex.org/W1984740259', 'https://openalex.org/W1984805407', 'https://openalex.org/W1986085856', 'https://openalex.org/W1991138829', 'https://openalex.org/W2001391476', 'https://openalex.org/W2004409542', 'https://openalex.org/W2005230361', 'https://openalex.org/W2009448348', 'https://openalex.org/W2013851956', 'https://openalex.org/W2029228033', 'https://openalex.org/W2033665483', 'https://openalex.org/W203832111', 'https://openalex.org/W2043092889', 'https://openalex.org/W2048811039', 'https://openalex.org/W2050826565', 'https://openalex.org/W2055849242', 'https://openalex.org/W2057913111', 'https://openalex.org/W2069375870', 'https://openalex.org/W2070710390', 'https://openalex.org/W2070762414', 'https://openalex.org/W2071835038', 'https://openalex.org/W2084948079', 'https://openalex.org/W2093738306', 'https://openalex.org/W2098459806', 'https://openalex.org/W2099102828', 'https://openalex.org/W2103525547', 'https://openalex.org/W2103684966', 'https://openalex.org/W2106036385', 'https://openalex.org/W2107949845', 'https://openalex.org/W2108646121', 'https://openalex.org/W2111765225', 'https://openalex.org/W2112981414', 'https://openalex.org/W2113367996', 'https://openalex.org/W2118710260', 'https://openalex.org/W2118762421', 'https://openalex.org/W2120774442', 'https://openalex.org/W2128077095', 'https://openalex.org/W2129934471', 'https://openalex.org/W2131490500', 'https://openalex.org/W2133001114', 'https://openalex.org/W2135940808', 'https://openalex.org/W2137352234', 'https://openalex.org/W2138077952', 'https://openalex.org/W2142400535', 'https://openalex.org/W2143768025', 'https://openalex.org/W2144812108', 'https://openalex.org/W2146901298', 'https://openalex.org/W2154705833', 'https://openalex.org/W2155617439', 'https://openalex.org/W2159198773', 'https://openalex.org/W2160001758', 'https://openalex.org/W2162001095', 'https://openalex.org/W2162934281', 'https://openalex.org/W2164416879', 'https://openalex.org/W2166494634', 'https://openalex.org/W2170606300', 'https://openalex.org/W2171512247', 'https://openalex.org/W2275116803', 'https://openalex.org/W2275139239', 'https://openalex.org/W2324992560', 'https://openalex.org/W2331319476', 'https://openalex.org/W2337454357', 'https://openalex.org/W2509949587', 'https://openalex.org/W91242618'], 'related_works': ['https://openalex.org/W4301087007', 'https://openalex.org/W3117830969', 'https://openalex.org/W2610552735', 'https://openalex.org/W2320948677', 'https://openalex.org/W2094157061', 'https://openalex.org/W2064365715', 'https://openalex.org/W2040563590', 'https://openalex.org/W1986085856', 'https://openalex.org/W1966991896', 'https://openalex.org/W1919558603'], 'abstract_inverted_index': {'Abstract': [0], 'Diet,': [1], 'lifestyle': [2], 'modification,': [3], 'and': [4, 58, 120, 149], 'pharmacotherapy': [5], 'with': [6, 15, 28, 71, 73, 89, 132, 140, 155, 177], 'metformin': [7, 29], 'are': [8, 143], 'appropriate': [9], 'initial': [10], 'treatments': [11], 'for': [12, 76, 175], 'many': [13], 'patients': [14, 87, 131, 176], 'type': [16], '2': [17], 'diabetes': [18], '(T2DM).': [19], 'However,': [20], 'most': [21, 135], 'individuals': [22], 'do': [23], 'not': [24], 'maintain': [25], 'glycemic': [26], 'control': [27], 'alone.': [30], 'Addition': [31], 'of': [32, 161, 165], 'other': [33], 'oral': [34], 'antidiabetes': [35], 'drugs': [36], '(OADs),': [37], 'including': [38, 50], 'sulfonylurea,': [39], 'meglitinide,': [40], 'or': [41, 68], 'thiazolidinedione,': [42], 'is': [43], 'often': [44, 128], 'the': [45], 'next': [46], 'step.': [47], 'Newer': [48], 'options,': [49], 'incretin-based': [51], 'glucagon-like': [52], 'peptide-1': [53], '(GLP-1)': [54], 'receptor': [55], 'agonists': [56], '(RAs)': [57], 'dipeptidyl': [59], 'peptidase-4': [60], '(DPP-4)': [61], 'inhibitors,': [62], 'offer': [63], 'important': [64], 'benefits': [65, 164], 'as': [66, 100], 'monotherapies': [67], 'in': [69, 79, 130, 153], 'combination': [70, 154], 'OADs,': [72], 'low': [74], 'risk': [75, 126], 'hypoglycemia.': [77], 'Reductions': [78], 'glycated': [80], 'hemoglobin': [81], '(A1C)': [82], 'have': [83, 121], 'been': [84], 'reported': [85], 'among': [86], 'treated': [88], 'GLP-1': [90, 114, 141, 166], 'RAs': [91, 115, 142], '(exenatide,': [92, 104], '-0.8': [93, 97], 'to': [94, 98, 106, 111], '-1.1%;': [95], 'liraglutide,': [96, 109], '-1.6%),': [99], 'has': [101], 'weight': [102], 'loss': [103], '-1.6': [105, 110], '-3.1': [107], 'kg;': [108], '-3.2': [112], 'kg).': [113], 'also': [116], 'stimulate': [117], 'β-cell': [118], 'responses': [119], 'positive': [122], 'effects': [123], 'on': [124], 'cardiovascular': [125], 'factors': [127], 'present': [129], 'T2DM.': [133, 178], 'The': [134], 'common': [136], 'adverse': [137], 'events': [138], 'associated': [139], 'nausea,': [144], 'which': [145], 'diminishes': [146], 'over': [147], 'time,': [148], 'hypoglycemia': [150], '(when': [151], 'used': [152], 'a': [156], 'sulfonylurea).': [157], 'A': [158], 'large': [159], 'number': [160], 'trials': [162], 'demonstrated': [163], 'RAs,': [167], 'suggesting': [168], 'they': [169], 'could': [170], 'provide': [171], 'suitable': [172], 'treatment': [173], 'options': [174]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995257796', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-17T00:26:29.892847', 'created_date': '2016-06-24'}