Publication Information

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'https://openalex.org/W2167069168', 'https://openalex.org/W2170996501', 'https://openalex.org/W2410709360', 'https://openalex.org/W2414407947', 'https://openalex.org/W29297141'], 'related_works': ['https://openalex.org/W3109480263', 'https://openalex.org/W3087396862', 'https://openalex.org/W2944031322', 'https://openalex.org/W2763822422', 'https://openalex.org/W2581873068', 'https://openalex.org/W2380389369', 'https://openalex.org/W2146029618', 'https://openalex.org/W2069387121', 'https://openalex.org/W1969303838', 'https://openalex.org/W1579755615'], 'abstract_inverted_index': {'Small': [0, 245], 'recombinant': [1, 246, 545, 2000, 2803, 3549], 'antibody': [2, 247, 1445, 2001, 2175, 2826, 2895, 3110, 3469], 'molecules': [3, 120, 248, 365, 546, 584, 658, 676, 729, 1149, 1284, 1542, 3294, 3301, 3347, 3550, 3588, 3727, 3745, 3798, 4221], 'such': [4, 249, 727, 901, 2003, 2903, 3796, 3971], 'as': [5, 250, 790, 798, 902, 1127, 1129, 1318, 1507, 1590, 1735, 1784, 1895, 1912, 2004, 2251, 2331, 2355, 2367, 2456, 2491, 2493, 2904, 2916, 2918, 3299, 3859, 3867, 3972, 4199, 4201], 'bispecific': [6, 228, 251, 473, 777, 1264, 1657, 1857, 3109, 3146, 3251, 3291, 3346, 3403, 3466, 3846, 4337], 'single-chain': [7, 252, 491, 596, 1265, 3495, 3600, 3635, 3660, 3667, 3692, 4338], 'diabodies': [8, 253, 492, 597, 3496, 3601], '(scDb)': [9, 254, 493, 3497], 'possessing': [10, 255, 992, 1917, 3295, 4063], 'a': [11, 61, 82, 200, 227, 256, 306, 327, 445, 472, 586, 743, 748, 776, 787, 809, 971, 980, 1000, 1008, 1104, 1151, 1214, 1270, 1329, 1365, 1455, 1460, 1494, 1502, 1549, 1597, 1618, 1664, 1715, 1773, 1792, 1799, 1905, 1918, 1924, 1930, 2071, 2197, 2243, 2265, 2362, 2374, 2929, 3145, 3158, 3250, 3296, 3432, 3438, 3446, 3590, 3812, 3817, 3845, 3856, 3878, 4042, 4051, 4071, 4079, 4175, 4223, 4286], 'molecular': [12, 257, 590, 2350, 3594], 'mass': [13, 258, 2351], 'of': [14, 29, 54, 60, 71, 106, 146, 154, 160, 178, 215, 226, 259, 274, 299, 305, 316, 351, 391, 399, 405, 423, 460, 471, 548, 556, 592, 607, 634, 656, 666, 726, 751, 817, 874, 904, 911, 916, 927, 937, 962, 970, 979, 988, 1124, 1131, 1189, 1192, 1229, 1237, 1259, 1314, 1339, 1353, 1450, 1463, 1537, 1580, 1600, 1613, 1628, 1633, 1730, 1749, 1760, 1776, 1795, 1798, 1830, 1836, 1848, 1855, 1939, 1951, 1962, 2091, 2097, 2139, 2144, 2153, 2164, 2173, 2186, 2316, 2328, 2342, 2352, 2377, 2438, 2447, 2513, 2522, 2534, 2589, 2634, 2637, 2657, 2668, 2691, 2802, 2912, 3144, 3160, 3237, 3290, 3343, 3427, 3445, 3464, 3489, 3552, 3560, 3596, 3611, 3703, 3725, 3735, 3795, 3820, 3886, 3944, 3974, 3981, 3986, 3997, 4007, 4033, 4041, 4050, 4059, 4196, 4203, 4261, 4264, 4301, 4309, 4332], '∼55': [15, 260, 593, 3597], 'kDa': [16, 261, 2195, 2335, 2354], 'are': [17, 262, 544, 632, 2681, 3076, 3392, 3456, 3548, 3701], 'rapidly': [18, 263], 'cleared': [19, 264], 'from': [20, 44, 265, 289, 730, 1015, 2177, 2541, 2786, 2824, 3799, 4086], 'circulation.': [21, 266], 'We': [22, 79, 267, 324, 1143, 4029, 4215], 'have': [23, 268, 598, 3602], 'recently': [24, 269, 959, 4030], 'extended': [25, 224, 270, 469, 1158, 2428, 3417, 4230], 'the': [26, 52, 58, 107, 144, 147, 150, 166, 179, 194, 213, 223, 271, 297, 303, 352, 389, 392, 395, 411, 424, 439, 458, 468, 502, 527, 549, 564, 605, 642, 664, 815, 924, 928, 948, 967, 1110, 1116, 1122, 1132, 1146, 1186, 1193, 1208, 1227, 1252, 1257, 1306, 1311, 1333, 1351, 1375, 1451, 1508, 1545, 1593, 1647, 1656, 1738, 1747, 1757, 1766, 1777, 1796, 1808, 1813, 1828, 1834, 1837, 1846, 1853, 1862, 1887, 1898, 1936, 1952, 1958, 2077, 2080, 2084, 2092, 2098, 2137, 2140, 2161, 2171, 2174, 2257, 2261, 2272, 2313, 2317, 2326, 2329, 2337, 2448, 2496, 2499, 2510, 2532, 2584, 2635, 2640, 2644, 2654, 2658, 2666, 2678, 2689, 2692, 2817, 2825, 2910, 2913, 2926, 3101, 3105, 3108, 3115, 3118, 3165, 3174, 3235, 3340, 3461, 3474, 3480, 3485, 3506, 3531, 3553, 3568, 3609, 3641, 3673, 3711, 3733, 3884, 3994, 3998, 4018, 4038, 4181, 4188, 4194, 4204, 4218, 4258, 4265, 4280, 4299, 4325, 4330], 'plasma': [27, 123, 152, 272, 368, 397, 872, 968, 1921, 3088, 3942, 4039], 'half-life': [28, 153, 159, 225, 273, 398, 404, 470, 655, 969, 1159, 1188, 1235, 1272, 1849, 1864, 1922, 2246, 2429, 2512, 2521, 2533, 2819, 3089, 3159, 3418, 3724, 4040, 4231, 4260, 4307], 'scDb': [30, 62, 180, 229, 275, 307, 425, 474, 631, 792, 972, 990, 1009, 1126, 1133, 1148, 1194, 1238, 1283, 1315, 1322, 1340, 1634, 1740, 1903, 2417, 2419, 2459, 3060, 3217, 3252, 3300, 3398, 3414, 3433, 3440, 3700, 3861, 4043, 4061, 4080, 4198, 4205, 4220, 4266, 4310], 'applying': [31, 276], 'various': [32, 277, 602, 1648, 1997, 2806, 3606], 'strategies': [33, 278, 885, 939, 964, 975, 3955, 4009, 4035, 4046], 'including': [34, 279, 604, 3608], 'PEGylation,': [35, 280, 2791], 'N-glycosylation': [36, 281, 918, 997, 1098, 3988, 4068, 4169], 'and': [37, 68, 100, 125, 138, 184, 282, 313, 345, 370, 383, 429, 552, 589, 783, 877, 882, 934, 952, 1007, 1114, 1155, 1198, 1267, 1293, 1316, 1323, 1341, 1639, 1724, 1741, 1804, 1833, 1868, 1923, 2009, 2083, 2418, 2649, 2676, 2784, 2793, 2834, 2897, 2909, 2924, 3090, 3152, 3279, 3399, 3424, 3556, 3593, 3852, 3947, 3952, 4004, 4022, 4078, 4185, 4227, 4270], 'fusion': [38, 109, 283, 354, 946, 953, 1004, 1869, 1889, 2794, 3426, 4016, 4023, 4075], 'to': [39, 75, 149, 182, 284, 320, 394, 427, 611, 639, 646, 741, 795, 879, 947, 956, 965, 1011, 1161, 1185, 1291, 1305, 1343, 1374, 1505, 1617, 1625, 1635, 1791, 1810, 1819, 1844, 1861, 1870, 1942, 2147, 2168, 2235, 2312, 2325, 2373, 2509, 2547, 2583, 2683, 2696, 2795, 2805, 3079, 3083, 3104, 3167, 3230, 3286, 3395, 3431, 3459, 3471, 3615, 3708, 3715, 3810, 3864, 3949, 4017, 4026, 4036, 4082, 4233, 4257], 'an': [40, 88, 285, 333, 791, 799, 1012, 1157, 1162, 1260, 1275, 1379, 1871, 2187, 2229, 2236, 2348, 2427, 2443, 2587, 2796, 3336, 3416, 3428, 3860, 3868, 4083, 4229, 4234, 4333], 'albumin-binding': [41, 286, 1013, 1380, 3429, 3637, 3669, 4084], 'domain': [42, 287, 1014, 2695, 3430, 3638, 3670, 4085], '(ABD)': [43, 288], 'streptococcal': [45, 290, 1016, 4087], 'protein': [46, 110, 291, 355, 1005, 1017, 2832, 4076, 4088], 'G.': [47, 292, 827, 839, 855, 2839, 2841, 3186, 3311, 3361, 3896, 3908, 3924], 'Here,': [48, 293], 'we': [49, 294, 1095, 1119, 1179, 1255, 1933, 2502, 2663, 3410, 4166, 4191, 4251, 4328], 'further': [50, 210, 295, 455, 940, 1120, 1224, 1743, 2424, 4010, 4192, 4296], 'analyzed': [51, 296, 1121, 3154, 4193], 'influence': [53, 298], 'these': [55, 219, 300, 464, 657, 938, 963, 1093, 1344, 1713, 1788, 2422, 2809, 3344, 3465, 3726, 4008, 4034, 4164], 'modifications': [56, 239, 301, 484, 1246, 1299, 1789, 1851, 1859, 4318], 'on': [57, 302, 1552, 1661, 1756, 1852, 2816, 2921, 3173, 3348], 'biodistribution': [59, 304, 1123, 1258, 2933, 4195, 4331], 'directed': [63, 308, 780, 1498, 2189, 3149, 3253, 3849], 'against': [64, 309, 781, 1499, 2190, 3150, 3254, 3850], 'carcinoembryonic': [65, 310, 3643, 3675], 'antigen': [66, 311, 1832, 2915, 3644, 3676], '(CEA)': [67, 312], 'CD3': [69, 314, 784, 3153, 3407, 3853], 'capable': [70, 315, 633, 3702], 'retargeting': [72, 317, 606, 636, 3610, 3705], 'T': [73, 318, 609, 1727, 1814, 3085, 3102, 3119, 3232, 3467, 3613], 'cells': [74, 186, 319, 431, 613, 638, 641, 1200, 1638, 1642, 1806, 3086, 3103, 3233, 3617, 3654, 3686, 3707, 3710, 4272], 'CEA-expressing': [76, 321, 1334], 'tumor': [77, 104, 322, 349, 612, 640, 1242, 1335, 1637, 1882, 1960, 1991, 2074, 2158, 2181, 2200, 2267, 2273, 2365, 2380, 2433, 2905, 2927, 3422, 3616, 3709, 4314], 'cells.': [78, 323, 1336, 1786], 'show': [80, 325, 1144, 4216], 'that': [81, 222, 238, 326, 467, 483, 1097, 1145, 1156, 1181, 1234, 1245, 1269, 1298, 1544, 1653, 1935, 2136, 2152, 2426, 2504, 2643, 2665, 2677, 2790, 2894, 3072, 3097, 3164, 3415, 3425, 4168, 4217, 4228, 4253, 4306, 4317], 'prolonged': [83, 328, 749, 1271, 3475, 3818], 'circulation': [84, 329, 731, 2245, 2436, 3175, 3476, 3800], 'time': [85, 330, 752, 2437, 3176, 3477, 3821], 'results': [86, 331, 1239, 1362, 1440, 2783, 3055, 4311], 'in': [87, 91, 132, 165, 212, 234, 332, 336, 377, 410, 457, 479, 563, 659, 663, 808, 1140, 1165, 1226, 1240, 1278, 1350, 1359, 1459, 1581, 1596, 1602, 1663, 1746, 1765, 1772, 1874, 1877, 1909, 2089, 2095, 2249, 2544, 2550, 2653, 2932, 3155, 3220, 3242, 3453, 3492, 3567, 3728, 3732, 3877, 4212, 4237, 4298, 4312], 'increased': [89, 334, 1101, 1163, 1241, 1276, 1875, 1894, 2364, 2432, 2444, 2455, 3421, 4172, 4235, 4313], 'accumulation': [90, 105, 233, 335, 350, 478, 1164, 1243, 1277, 1313, 1876, 1883, 1908, 1992, 2075, 2085, 2201, 2366, 2376, 3423, 4236, 4315], 'CEA+': [92, 337, 1636, 1878, 1910], 'tumors,': [93, 338], 'which': [94, 208, 339, 453, 1222, 1370, 1622, 1891, 1955, 2322, 2452, 2538, 2829, 3080, 4294], 'was': [95, 111, 156, 162, 187, 204, 209, 340, 356, 401, 407, 432, 449, 454, 1107, 1171, 1218, 1223, 1347, 1371, 1608, 1643, 1718, 1732, 1742, 1884, 1892, 1993, 2086, 2233, 2275, 2524, 2539, 4178, 4243, 4290, 4295], 'most': [96, 341], 'pronounced': [97, 342], 'for': [98, 128, 174, 206, 343, 373, 419, 451, 601, 614, 673, 814, 1109, 1173, 1196, 1220, 1289, 1332, 1364, 1443, 1492, 1720, 1886, 1996, 2336, 2415, 2531, 2688, 3059, 3240, 3412, 3479, 3484, 3605, 3618, 3742, 3883, 4180, 4245, 4268, 4292], 'scDb-ABD': [99, 108, 155, 161, 344, 353, 400, 406, 1324, 1342, 1731, 1888, 1940, 1963, 2165, 2253, 2439, 2449, 2523, 2638, 2669], 'PEGylated': [101, 116, 175, 346, 361, 420, 1111, 1321, 1444, 1495, 1630, 1722, 1902, 1953, 2005, 2416, 3439, 4182], 'scDb.': [102, 176, 347, 421, 1762, 1900], 'Interestingly,': [103, 348, 1901], '∼2-fold': [112, 163, 357, 408, 1906, 2454], 'higher': [113, 358, 1920, 2073], 'compared': [114, 197, 359, 442, 669, 1211, 1319, 1591, 1736, 1896, 1913, 1947, 2332, 2368, 2457, 3436, 3738, 4283], 'with': [115, 198, 360, 443, 585, 670, 1212, 1303, 1320, 1361, 1454, 1592, 1737, 1897, 1914, 1948, 2192, 2256, 2333, 2347, 2369, 2410, 2458, 2586, 3437, 3589, 3739, 4284], 'scDb,': [117, 199, 362, 444, 985, 1112, 1136, 1138, 1213, 1723, 1954, 4056, 4183, 4208, 4210, 4285], 'although': [118, 363, 1916], 'both': [119, 364], 'exhibit': [121, 366, 1150, 4222], 'similar': [122, 126, 367, 371, 788, 1286, 1503, 1624, 1925, 2244, 2266, 2324, 2682, 3297, 3857], 'half-lives': [124, 131, 369, 376, 873, 3943], 'affinities': [127, 372, 2680], 'CEA.': [129, 374], 'Comparing': [130, 375], 'neonatal': [133, 378, 3645, 3677], 'Fc': [134, 379, 505, 530, 950, 3509, 3534, 3646, 3678, 4020], 'receptor': [135, 380, 1816, 3647, 3679], '(FcRn)': [136, 381], 'wild-type': [137, 382, 1509, 2545], 'FcRn': [139, 148, 384, 393, 1176, 2507, 2516, 2585, 2641, 2650, 4248], 'heavy': [140, 385, 551, 2517, 2551, 3555], 'chain': [141, 386, 554, 983, 2518, 2552, 3558, 4054], 'knock-out': [142, 167, 387, 412, 1177, 2519, 2553, 4249], 'mice': [143, 388, 660, 1178, 2250, 2520, 2546, 2554, 3455, 3729, 4250], 'contribution': [145, 390], 'long': [151, 396, 1187, 2435, 2511, 4259], 'confirmed.': [157, 402], 'The': [158, 403, 653, 723, 1168, 1726, 1880, 2068, 2131, 2183, 2239, 3216, 3722, 3792, 4240], 'lower': [164, 409, 1907], 'mice,': [168, 413], 'while': [169, 414, 1103, 1751, 4174], 'no': [170, 415, 1606, 1754, 3073, 3170], 'differences': [171, 416], 'were': [172, 417, 1201, 1441, 2529, 4273], 'observed': [173, 205, 418, 450, 1108, 1172, 1219, 1609, 1719, 1995, 3483, 4179, 4244, 4291], 'Binding': [177, 422], 'derivatives': [181, 426, 1134, 1195, 3401, 3470, 4206, 4267], 'target': [183, 428, 1197, 1665, 1803, 1831, 2914, 2922, 3063, 3106, 3486, 4269], 'effector': [185, 430, 637, 1199, 1641, 1785, 1805, 3706, 4271], 'not': [188, 433, 1202, 1301, 1326, 1348, 1644, 2671, 2812, 3228, 4274], 'or': [189, 434, 738, 909, 954, 995, 1203, 1378, 3807, 3979, 4024, 4066, 4275], 'only': [190, 435, 662, 1099, 1204, 2813, 3731, 4170, 4276], 'marginally': [191, 436, 1205, 4277], 'affected': [192, 437, 1206, 1349, 1645, 4278], 'by': [193, 438, 560, 1207, 1328, 1646, 1827, 2357, 2442, 2495, 2506, 2686, 3117, 3284, 3442, 3564, 4279], 'modifications,': [195, 440, 1209, 1649, 4281], 'although,': [196, 441, 1210, 4282], 'reduced': [201, 211, 446, 456, 1152, 1215, 1225, 1312, 1330, 1734, 1744, 2525, 2540, 3481, 4224, 4287, 4297], 'cytotoxic': [202, 447, 608, 1216, 1778, 3612, 4288], 'activity': [203, 448, 1217, 1660, 1729, 1759, 3463, 4289], 'scDb-ABD,': [207, 452, 1221, 1915, 2330, 2647, 4293], 'presence': [214, 459, 1228, 1352, 1748, 4300], 'albumin.': [216, 461, 1230, 1355, 4028, 4302], 'In': [217, 462, 1092, 1437, 1604, 1712, 1929, 2498, 2515, 2660, 3066, 3335, 4163, 4187], 'summary,': [218, 463, 3409], 'findings': [220, 465, 1232, 4304], 'demonstrate': [221, 466, 1233, 2789, 4305], 'translates': [230, 475, 1273, 2430, 3419], 'into': [231, 476, 583, 1274, 2431, 3402, 3420, 3587], 'improved': [232, 477], 'antigen-positive': [235, 480, 1166, 4238], 'tumors': [236, 481, 1911, 3350], 'but': [237, 482, 1244, 2269, 2822, 2899, 4316], 'might': [240, 485, 1247, 1823, 1956, 2179, 2309, 2811, 3056, 4319], 'also': [241, 486, 1248, 1771, 1824, 1994, 2134, 2823, 2900, 4320], 'affect': [242, 487, 1249, 4321], 'scDb-mediated': [243, 488, 1250, 4322], 'cytotoxicity.': [244, 489, 4323], 'Bispecific': [490, 595, 3494, 3599], '2The': [494, 519, 3498, 3523], 'abbreviations': [495, 520, 3499, 3524], 'used': [496, 521, 3219, 3283, 3500, 3525], 'are:': [497, 522, 3501, 3526], 'scDbsingle-chain': [498, 523, 3502, 3527], 'diabodyABDalbumin-binding': [499, 524, 3503, 3528], 'domainAUCarea': [500, 525, 3504, 3529], 'under': [501, 526, 3505, 3530, 3640, 3672], 'curveCEAcarcinoembryonic': [503, 528, 3507, 3532], 'antigenFcRnneonatal': [504, 529, 3508, 3533], 'receptorHSAhuman': [506, 531, 3510, 3535], 'serum': [507, 532, 957, 1002, 1354, 3511, 3536, 3649, 3681, 4027, 4073], 'albuminPBMCperipheral': [508, 533, 3512, 3537], 'blood': [509, 534, 3513, 3538, 3652, 3684], 'mononuclear': [510, 535, 3514, 3539, 3653, 3685], 'cellsPEGpolyethylene': [511, 536, 3515, 3540], 'glycolQCMquartz': [512, 537, 3516, 3541], 'crystal': [513, 538, 3517, 3542, 3658, 3690], 'microbalancescFvsingle-chain': [514, 539, 3518, 3543], 'fragment': [515, 540, 3519, 3544, 3661, 3693], 'variableMTTmethylthiazolyldiphenyl-tetrazolium': [516, 541, 3520, 3545], 'bromidewtwild': [517, 542, 3521, 3546], 'type.': [518, 543, 3522, 3547, 3666, 3698], 'composed': [547, 3551], 'variable': [550, 3554, 3662, 3694], 'light': [553, 3557], 'domains': [555, 581, 3559, 3585], 'two': [557, 3561], 'antibodies': [558, 2804, 3562], 'connected': [559, 3563], 'three': [561, 1130, 3565, 4202], 'linkers': [562, 3566], 'order': [565, 3569], 'VHA-VLB-VHB-VLA': [566, 3570], '(1Kontermann': [567, 3571], 'R.E.': [568, 621, 688, 710, 890, 1031, 1053, 1075, 1673, 1695, 1973, 2474, 3572, 3625, 3757, 3779, 3960, 4102, 4124, 4146], 'Acta': [569, 3573], 'Pharmacol.': [570, 3574], 'Sin.': [571, 3575], '2005;': [572, 3576], '26:': [573, 3577], '1-9Crossref': [574, 3578], 'PubMed': [575, 700, 718, 769, 866, 895, 1043, 1061, 1087, 1402, 1432, 1486, 1529, 1573, 1681, 1707, 1985, 2037, 2063, 2126, 2223, 2303, 2400, 2486, 2575, 2608, 2627, 2718, 2736, 2778, 2885, 2978, 3007, 3137, 3211, 3274, 3330, 3385, 3579, 3769, 3787, 3838, 3935, 3965, 4114, 4132, 4158], 'Scopus': [576, 701, 719, 770, 867, 896, 1044, 1062, 1088, 1403, 1433, 1487, 1530, 1574, 1682, 1708, 1986, 2038, 2064, 2127, 2224, 2304, 2401, 2487, 2576, 2609, 2628, 2719, 2737, 2779, 2886, 2979, 3008, 3138, 3212, 3275, 3331, 3386, 3580, 3770, 3788, 3839, 3936, 3966, 4115, 4133, 4159], '(113)': [577, 3581], 'Google': [578, 629, 703, 721, 772, 869, 898, 1046, 1064, 1090, 1405, 1435, 1489, 1532, 1576, 1684, 1710, 1988, 2040, 2066, 2129, 2226, 2306, 2403, 2489, 2578, 2611, 2630, 2721, 2739, 2781, 2855, 2888, 2953, 2981, 3010, 3032, 3051, 3140, 3214, 3277, 3333, 3388, 3582, 3633, 3772, 3790, 3841, 3938, 3968, 4117, 4135, 4161], 'Scholar).': [579, 722, 773, 899, 1091, 1436, 1533, 1577, 1711, 1989, 2067, 2130, 2227, 2307, 2404, 2579, 2631, 2889, 3052, 3141, 3215, 3334, 3389, 3583, 3634, 3791, 3842, 3939, 3969, 4162], 'These': [580, 974, 1231, 2405, 3584, 4045, 4303], 'assemble': [582, 3586], 'compact': [587, 3591], 'structure': [588, 3592], 'masses': [591, 3595], 'kDa.': [594, 3598], 'been': [599, 3281, 3603], 'developed': [600, 3604], 'applications': [603, 3607], 'lymphocytes': [610, 3614], 'cellular': [615, 3490, 3619], 'cancer': [616, 3620], 'therapy': [617, 3621], '(2Müller': [618, 3622], 'D.': [619, 678, 708, 762, 1021, 1051, 1071, 1412, 1559, 1671, 1691, 1969, 2017, 2106, 2386, 2470, 2837, 2876, 3623, 3747, 3777, 3831, 4092, 4122, 4142], 'Kontermann': [620, 687, 709, 1030, 1052, 1074, 1672, 1694, 1972, 2473, 3624, 3756, 3778, 4101, 4123, 4145], 'Curr.': [622, 763, 3626, 3832], 'Opin.': [623, 764, 3627, 3833], 'Mol.': [624, 2297, 3628], 'Ther.': [625, 2299, 3270, 3629], '2007;': [626, 692, 715, 1035, 1058, 1399, 1429, 1678, 2034, 2123, 3630, 3761, 3784, 4106, 4129], '9:': [627, 3631], '319-326PubMed': [628, 3632], 'Scholar).Although': [630], 'efficiently': [635, 1811, 3704], 'small': [643, 728, 3345, 3712, 3797], 'size': [644, 789, 2138, 2315, 2327, 2358, 2833, 3298, 3713, 3858], 'leads': [645, 1160, 3714, 4232], 'their': [647, 3716], 'rapid': [648, 3717], 'elimination': [649, 3718], 'after': [650, 1610, 3719], 'i.v.': [651, 3720], 'injection.': [652, 3721], 'terminal': [654, 3723], 'is': [661, 1325, 1358, 1623, 1944, 2149, 2323, 2440, 2453, 2642, 2670, 2892, 3070, 3111, 3223, 3261, 3434, 3730], 'range': [665, 3734], '5–6': [667, 3736], 'h,': [668, 3162, 3737], 'several': [671, 884, 961, 3740, 3954, 4032], 'days': [672, 3741], 'whole': [674, 3743], 'IgG': [675, 949, 2100, 2154, 2259, 2338, 3744, 4019], '(3Müller': [677, 1020, 3746, 4091], 'Karle': [679, 1022, 3748, 4093], 'A.': [680, 837, 847, 1023, 1394, 1418, 1474, 1515, 1555, 2023, 2051, 2112, 2211, 2382, 2702, 2845, 2868, 2870, 2988, 3368, 3749, 3906, 3916, 4094], 'Meissburger': [681, 1024, 3750, 4095], 'B.': [682, 1025, 2866, 3178, 3323, 3355, 3751, 4096], 'Höfig': [683, 1026, 3752, 4097], 'I.': [684, 1027, 1386, 2601, 3359, 3753, 4098], 'Stork': [685, 1028, 3754, 4099], 'R.': [686, 706, 823, 835, 1029, 1049, 1067, 1414, 1426, 1470, 1669, 1687, 1965, 2019, 2031, 2047, 2108, 2120, 2207, 2466, 2937, 2994, 3015, 3200, 3319, 3372, 3374, 3755, 3775, 3892, 3904, 4100, 4120, 4138], 'J.': [689, 1032, 1076, 1475, 1696, 1974, 2052, 2212, 2475, 2569, 2599, 2603, 2704, 2767, 2849, 2872, 2880, 3021, 3758, 4103, 4147], 'Biol.': [690, 1033, 1077, 1476, 1697, 1975, 2053, 2213, 2476, 2768, 3759, 4104, 4148], 'Chem.': [691, 1034, 1078, 1477, 1569, 1698, 1976, 2054, 2214, 2396, 2477, 2769, 3760, 4105, 4149], '282:': [693, 1036, 3762, 4107], '12650-12660Abstract': [694, 1037, 3763, 4108], 'Full': [695, 697, 1038, 1040, 1082, 1084, 1481, 1483, 1702, 1704, 1980, 1982, 2058, 2060, 2218, 2220, 2481, 2483, 2773, 2775, 3764, 3766, 4109, 4111, 4153, 4155], 'Text': [696, 698, 1039, 1041, 1083, 1085, 1482, 1484, 1703, 1705, 1981, 1983, 2059, 2061, 2219, 2221, 2482, 2484, 2774, 2776, 3765, 3767, 4110, 4112, 4154, 4156], 'PDF': [699, 1042, 1086, 1485, 1706, 1984, 2062, 2222, 2485, 2777, 3768, 4113, 4157], '(189)': [702, 1045, 3771, 4116], 'Scholar,': [704, 1047, 1065, 1406, 1685, 2041, 2612, 2722, 2740, 2856, 2954, 2982, 3011, 3033, 3773, 4118, 4136], '4Stork': [705, 1048, 3774, 4119], 'Müller': [707, 1050, 1070, 1670, 1690, 1968, 2469, 3776, 4121, 4141], 'Protein': [711, 1054, 1395, 1522, 1674, 2711, 2731, 3780, 4125], 'Eng.': [712, 1055, 1396, 1523, 1675, 2712, 3781, 4126], 'Des.': [713, 1056, 1397, 1524, 1676, 2713, 3782, 4127], 'Sel.': [714, 1057, 1398, 1525, 1677, 2714, 3783, 4128], '20:': [716, 1059, 1400, 1571, 1679, 2398, 3785, 4130], '569-576Crossref': [717, 1060, 1680, 3786, 4131], '(92)': [720, 1063, 1683, 3789, 4134], 'fast': [724, 3793], 'clearance': [725, 1154, 3794, 4226], 'hampers': [732, 3801], 'therapeutic': [733, 875, 3802, 3945], 'applications,': [734, 3803], 'e.g.': [735, 945, 3804, 4015], 'requiring': [736, 3805], 'infusions': [737, 3806], 'repeated': [739, 3808], 'injections': [740, 3809], 'maintain': [742, 3811], 'therapeutically': [744, 3813], 'effective': [745, 3814], 'dose': [746, 803, 3815, 3872], 'over': [747, 3816], 'period': [750, 3819], '(5Batra': [753, 3822], 'S.K.': [754, 2847, 3823], 'Jain': [755, 1560, 2387, 3131, 3824], 'M.': [756, 829, 831, 841, 853, 1384, 1390, 1563, 2283, 2286, 2390, 2724, 2728, 2754, 2758, 2766, 2862, 2992, 3013, 3303, 3305, 3370, 3825, 3898, 3900, 3910, 3922], 'Wittel': [757, 3826], 'U.A.': [758, 3827], 'Chauhan': [759, 3828], 'S.C.': [760, 3124, 3829], 'Colcher': [761, 3830], 'Biotechnol.': [765, 3834], '2002;': [766, 2733, 2770, 2882, 3134, 3835], '13:': [767, 3836], '603-608Crossref': [768, 3837], '(162)': [771, 3840], 'For': [774, 3843], 'example,': [775, 1493, 3844], 'tandem': [778, 1496, 1510, 2231, 3147, 3292, 3847], 'scFv': [779, 1452, 1497, 1511, 1540, 1588, 1595, 2007, 2188, 2344, 3148, 3259, 3293, 3848], 'CD19': [782, 3151, 3851], '(blinatumomab)': [785, 3854], 'having': [786, 3855], 'molecule': [793, 2141, 3862], 'had': [794, 1753, 3863], 'be': [796, 887, 1825, 2310, 2814, 3057, 3247, 3352, 3865, 3957], 'given': [797, 3866], '8-week': [800, 3869], 'infusion': [801, 3870], '(maximum': [802, 3871], '60': [804, 3873], 'μg/m2': [805, 3874], 'per': [806, 1587, 3875], 'day)': [807, 3876], 'clinical': [810, 3879], 'phase': [811, 3880], 'I': [812, 3881], 'trial': [813, 3882], 'treatment': [816, 3885], 'B': [818, 3887], 'cell': [819, 1295, 1307, 1345, 1815, 1926, 2923, 3064, 3120, 3888], 'lymphoma': [820, 3889], 'patients': [821, 3890], '(6Bargou': [822, 3891], 'Leo': [824, 3197, 3893], 'E.': [825, 1468, 2045, 2205, 2860, 3198, 3309, 3894], 'Zugmaier': [826, 3895], 'Klinger': [828, 3897], 'Goebeler': [830, 3899], 'Knop': [832, 3901], 'S.': [833, 1420, 1424, 1466, 1561, 2025, 2029, 2043, 2114, 2118, 2203, 2388, 2558, 2730, 2750, 2764, 3192, 3365, 3902], 'Noppeney': [834, 3903], 'Viardot': [836, 3905], 'Hess': [838, 3907], 'Schuler': [840, 3909], 'Einsele': [842, 3911], 'H.': [843, 1388, 1410, 2015, 2104, 2746, 3912], 'Brandl': [844, 3189, 3913], 'C.': [845, 857, 2556, 2614, 3017, 3180, 3190, 3914, 3926], 'Wolf': [846, 2940, 3915], 'Kirchinger': [848, 3917], 'P.': [849, 851, 861, 2752, 2864, 3184, 3307, 3317, 3357, 3376, 3918, 3920, 3930], 'Klappers': [850, 3919], 'Schmidt': [852, 3921], 'Riethmüller': [854, 3923], 'Reinhardt': [856, 3925], 'Baeuerle': [858, 3203, 3320, 3377, 3927], 'P.A.': [859, 2710, 2756, 3204, 3321, 3378, 3928], 'Kufer': [860, 3183, 3316, 3375, 3929], 'Science.': [862, 3931], '2008;': [863, 1079, 1699, 1977, 2300, 2478, 2715, 3932, 4150], '321:': [864, 3933], '974-977Crossref': [865, 3934], '(807)': [868, 3937], 'Scholar).To': [870], 'extend': [871, 3081, 3941], 'proteins': [876, 3946], 'thus': [878, 930, 3948, 4000], 'improve': [880, 966, 2799, 3950, 4037], 'pharmacokinetics': [881, 3951], 'pharmacodynamics,': [883, 3953], 'can': [886, 2798, 3246, 3956], 'applied': [888, 960, 2818, 3958, 4031], '(7Kontermann': [889, 3959], 'BioDrugs.': [891, 3961], '2009;': [892, 1570, 2397, 3327, 3962], '23:': [893, 3963], '93-109Crossref': [894, 3964], '(172)': [897, 3967], 'Strategies': [900, 3970], 'conjugation': [903, 978, 1449, 1546, 1612, 2185, 3444, 3973, 4049], 'polyethylene': [905, 3655, 3687, 3975], 'glycol': [906, 3656, 3688, 3976], 'chains': [907, 1586, 3977], '(PEGylation)': [908, 3978], 'production': [910, 987, 3980, 4058], 'hyperglycosylated': [912, 3982], 'variants': [913, 991, 3983, 4062], 'through': [914, 1817, 3984], 'introduction': [915, 3985], 'additional': [917, 3987], 'sites': [919, 998, 3989, 4069], 'primarily': [920, 3990], 'aim': [921, 3991], 'at': [922, 2592, 2673, 2698, 3992], 'increasing': [923, 3993], 'hydrodynamic': [925, 1937, 2445, 3995], 'volume': [926, 3996], 'molecule,': [929, 3999], 'reducing': [931, 4001], 'renal': [932, 1153, 4002, 4225], 'filtration': [933, 4003], 'degradation.': [935, 4005], 'Some': [936, 4006], 'implement': [941, 4011], 'FcRn-mediated': [942, 1182, 4012, 4254], 'recycling': [943, 1183, 2494, 2505, 2636, 4013, 4255], 'processes,': [944, 4014], 'region': [951, 4021], 'binding': [955, 1290, 1304, 1338, 1504, 1601, 1632, 1818, 1927, 2081, 2163, 2690, 3082, 3166, 4025], 'albumin.We': [958], 'molecule.': [973, 2339, 4044], 'included': [976, 4047], 'site-directed': [977, 1611, 2184, 3443, 4048], '40-kDa': [981, 3447, 4052], 'PEG': [982, 1457, 2193, 3449, 4053], '(PEGylated': [984, 1135, 4055, 4207], 'scDb-A′-PEG40k),': [986, 4057], 'N-glycosylated': [989, 1137, 4060, 4209], '3,': [993, 4064], '6,': [994, 4065], '9': [996, 4067], '(scDb-ABC1–7),': [999, 4070], 'scDb-human': [1001, 4072], 'albumin': [1003, 2148, 2450, 2648, 3650, 3682, 4074], '(scDb-HSA),': [1006, 4077], 'fused': [1010, 1373, 2234, 4081], 'G': [1018, 4089], '(scDb-ABD)': [1019, 4090], '8Stork': [1066, 1686, 4137], 'Zettlitz': [1068, 1688, 1966, 2467, 4139], 'K.A.': [1069, 1565, 1689, 1967, 2392, 2468, 4140], 'Hanisch': [1072, 1692, 1970, 2471, 4143], 'F.-G.': [1073, 1693, 1971, 2472, 4144], '283:': [1080, 1700, 1978, 2479, 4151], '7804-7812Abstract': [1081, 1701, 1979, 2480, 4152], '(81)': [1089, 1709, 1987, 2488, 4160], 'studies': [1094, 1651, 1840, 2662, 3391, 3452, 4165], 'showed': [1096, 1268, 1501, 1652, 1904, 1934, 2070, 2264, 2361, 3411, 4167], 'moderately': [1100, 4171], 'half-life,': [1102, 4173], 'strong': [1105, 1550, 4176], 'improvement': [1106, 1170, 4177, 4242], 'scDb-HSA,': [1113, 4184], 'scDb-ABD.In': [1115], 'present': [1117, 1253, 1767, 2500, 4189, 4326], 'study': [1118, 1254, 1536, 2501, 3222, 3287, 4190, 4327], 'unmodified': [1125, 1594, 1739, 1761, 1899, 2370, 4197], 'well': [1128, 2409, 2492, 2917, 4200], 'scDb-ABD)': [1139, 4211], 'tumor-bearing': [1141, 4213], 'mice.': [1142, 3243, 4214], 'modified': [1147, 1282, 4219], 'tumors.': [1167, 1280, 1879, 4239], 'strongest': [1169, 4241], 'scDb-ABD.': [1174, 1190, 1725, 2420, 2514, 4186, 4246, 4262], 'Using': [1175, 4247], 'confirmed': [1180, 2503, 4252], 'contributes': [1184, 2508, 4256], 'Affinities': [1191, 4263], 'extension': [1236, 2820, 4308], 'cytotoxicity.DISCUSSIONIn': [1251], 'determined': [1256, 2356, 2685, 4329], 'anti-CEA': [1261, 1539, 2343, 3404, 4334], '×': [1262, 3405, 4335], 'anti-CD3': [1263, 4336], 'diabody': [1266, 3636, 3668], 'CEA-positive': [1279], 'All': [1281], 'exhibited': [1285], 'EC50': [1287], 'values': [1288, 2528], 'CEA-': [1292], 'CD3-expressing': [1294], 'lines': [1296, 1346], 'indicating': [1297, 3163], 'do': [1300], 'interfere': [1302], 'surface-exposed': [1308], 'antigens.': [1309, 3065], 'Thus,': [1310, 1447, 2421, 3053], 'scDb-ABC7': [1317], 'caused': [1327, 2196, 2441], 'affinity': [1331, 1464, 2588, 2667, 2896], 'Furthermore,': [1337, 2160, 2890], 'This': [1356, 1821, 2308, 3244], 'finding': [1357, 2133], 'accordance': [1360], 'obtained': [1363, 2414, 3058], 'half-life-extended': [1366, 1999], 'anti-HER2': [1367, 2006, 2010], 'Fab': [1368, 2078], '4D5,': [1369], 'either': [1372], 'same': [1376], 'ABD': [1377, 2694, 2797], 'peptide': [1381], '(AB.Fab4D5)': [1382], '(12Schlapschy': [1383], 'Theobald': [1385], 'Mack': [1387], 'Schottelius': [1389], 'Wester': [1391], 'H.J.': [1392, 2291], 'Skerra': [1393], '273-284Crossref': [1401], '(84)': [1404], '13Dennis': [1407], 'M.S.': [1408, 2013, 2102, 2958], 'Jin': [1409, 2014, 2103], 'Dugger': [1411, 2016, 2105], 'Yang': [1413, 2018, 2107], 'McFarland': [1415, 2020, 2109], 'L.': [1416, 2021, 2110, 2708, 2760, 2858, 2878, 3313], 'Ogasawara': [1417, 2022, 2111], 'Williams': [1419, 2024, 2113, 2989], 'Cole': [1421, 2026, 2115], 'M.J.': [1422, 2027, 2116, 3019], 'Ross': [1423, 2028, 2117], 'Schwall': [1425, 2030, 2119], 'Cancer': [1427, 2032, 2121, 2298, 2948, 2973, 3027, 3046, 3205, 3324, 3379], 'Res.': [1428, 2033, 2122, 2949, 2974, 3028, 3047], '67:': [1430, 2035, 2124], '254-261Crossref': [1431, 2036, 2125], '(194)': [1434, 2039, 2128, 3009], 'contrast,': [1438, 1605], 'different': [1439, 3054], 'described': [1442], 'fragments.': [1446], 'C-terminal': [1448, 1619], '4D5': [1453, 2008], '20-kDa': [1456], 'resulted': [1458, 1589, 1770, 1873], '5-fold': [1461], 'loss': [1462], '(14Kubetzko': [1465, 2202], 'Balic': [1467, 2044, 2204], 'Waibel': [1469, 2046, 2206], 'Zangemeister-Wittke': [1471, 2048, 2208], 'U.': [1472, 2049, 2209], 'Plückthun': [1473, 2050, 2210], '2006;': [1478, 1526, 2055, 2215, 2605, 2624, 2975, 3208, 3382], '281:': [1479, 2056, 2216], '35186-35201Abstract': [1480, 2057, 2217], '(105)': [1488, 2065, 2225], 'Scholar),': [1490, 2490], 'while,': [1491], 'MUC-1': [1500, 1506], '(15Xiong': [1512], 'C.Y.': [1513], 'Natarajan': [1514], 'Shi': [1516], 'X.B.': [1517], 'Denardo': [1518, 1520], 'G.L.': [1519], 'S.J.': [1521], '19:': [1527], '359-367Crossref': [1528], '(24)': [1531], 'A': [1534, 2632, 3092, 3257], 'recent': [1535], 'polysialylated': [1538], 'MFE-23': [1541, 2345], 'revealed': [1543, 2242, 3157], 'chemistry': [1547], 'has': [1548, 3169, 3280], 'effect': [1551, 1755, 3342], 'immunoreactivity': [1553], '(16Constantinou': [1554, 2381], 'Epenetos': [1556, 2383], 'A.A.': [1557, 2384], 'Hreczuk-Hirst': [1558, 2385], 'Wright': [1562, 2389], 'Chester': [1564, 2391], 'Deonarain': [1566, 2393], 'M.P.': [1567, 2394], 'Bioconjugate': [1568, 2395], '924-931Crossref': [1572, 2399], '(47)': [1575, 2402, 2738], 'Random': [1578], 'polysialylation': [1579, 2341], 'average': [1582], '1.4': [1583], '11-kDa': [1584], 'PSA': [1585, 1615], '20-fold': [1598], 'reduction': [1599, 1607, 1717, 1775, 1822], 'ELISA.': [1603], '1': [1614], 'polymer': [1616], 'cysteine': [1620], 'residue,': [1621], 'our': [1626, 2252, 2411, 3221, 3397, 3413], 'approach': [1627], 'generating': [1629], 'scDb.Although': [1631], 'CD3+': [1640], 'previous': [1650, 1931], 'they': [1654], 'reduce': [1655], 'antibody-mediated': [1658], 'stimulatory': [1659], 'PBMCs': [1662, 1783], 'cell-dependent': [1666, 3487], 'assay': [1667], '(4Stork': [1668], 'studies,': [1714], '3–12-fold': [1716], 'scDb-ABC7,': [1721], 'cell-stimulating': [1728], '3-fold': [1733], '4-fold': [1745], 'HSA,': [1750], 'HSA': [1752, 1943, 2580, 2697], 'stimulating': [1758], 'As': [1763], 'shown': [1764], 'study,': [1768, 1932], 'this': [1769, 3067, 3238], 'comparable': [1774], 'effects': [1779, 1847, 3289], 'using': [1780, 3249], 'preactivated': [1781], 'human': [1782, 3648, 3680], 'Presumably,': [1787], 'lead': [1790], 'sterical': [1793], 'hindrance': [1794], 'formation': [1797], 'close': [1800], 'contact': [1801], 'between': [1802, 2646], 'and/or': [1807], 'ability': [1809], 'activate': [1812], 'CD3.': [1820, 3256], 'influenced': [1826], 'choice': [1829], 'location': [1835], 'epitope.': [1838], 'Further': [1839, 3390, 3451], 'are,': [1841], 'therefore,': [1842, 3226], 'required': [1843], 'investigate': [1845, 3460], 'extending': [1850], 'bioactivity': [1854, 3482], 'other': [1856, 1998, 2901, 3062], 'antibodies.The': [1858], 'leading': [1860, 2372], 'longest': [1863], 'extension,': [1865], 'i.e.': [1866], 'PEGylation': [1867], 'ABD,': [1872], 'highest': [1881], 'found': [1885, 2664], 'protein,': [1890], '∼5-fold': [1893], 'slightly': [1919], 'activity.': [1928], 'radius': [1938, 2446], 'bound': [1941, 2146], '4.8': [1945], 'nm': [1946, 1950, 2461], '7.9': [1949], 'explain': [1957], 'better': [1959, 2199], 'penetration': [1961], '(8Stork': [1964, 2465], 'Increased': [1990], 'molecules,': [2002], 'AB.Fab4D5': [2011], '(13Dennis': [2012, 2101], '14Kubetzko': [2042], 'AB.Fab': [2069, 2093, 2145], '5–6-fold': [2072], 'than': [2076, 2094, 3099], 'without': [2079], 'peptide,': [2082], 'much': [2087], 'faster': [2088], 'case': [2090, 2096], 'parental': [2099], 'latter': [2132], 'indicates': [2135], '(the': [2142], 'MW': [2143], '∼130': [2150], 'kDa,': [2151], '150': [2155, 2334], 'kDa)': [2156], 'influences': [2157], 'accumulation.': [2159], 'noncovalent': [2162], '(and': [2166], 'AB.Fab)': [2167], 'albumin,': [2169, 2178, 2537], 'allowing': [2170], 'dissociation': [2172], 'moiety': [2176], 'facilitate': [2180], 'penetration.': [2182], 'HER2': [2191], '20': [2194], '8.5-fold': [2198], 'Recently': [2228], 'anti-EGFR': [2230, 2258], 'nanobody': [2232, 2240, 2262, 2318], 'anti-albumin': [2237], 'nanobody.': [2238], 'construct': [2241, 2263, 2319], '(∼48': [2247], 'h)': [2248], 'construct.': [2254], 'Compared': [2255], 'cetuximab,': [2260], 'accumulation,': [2268], 'distribution': [2270], 'within': [2271, 2925], 'tissue': [2274], 'more': [2276], 'homogeneous': [2277], '(17Tijink': [2278], 'B.M.': [2279], 'Laeremans': [2280], 'T.': [2281, 2288, 2762, 2998, 3182], 'Budde': [2282], 'Stigter-van': [2284], 'Walsum': [2285], 'Dreier': [2287, 3181], 'de': [2289], 'Haard': [2290], 'Leemans': [2292], 'C.R.': [2293], 'van': [2294, 3022], 'Dongen': [2295], 'G.A.': [2296], '7:': [2301, 3272], '2288-2297Crossref': [2302], '(223)': [2305], 'due': [2311], 'smaller': [2314], '(∼50': [2320], 'kDa),': [2321], 'Site-directed': [2340], '(MFE-23-Cys-PSA)': [2346], 'apparent': [2349], '>300': [2353], 'exclusion': [2359], 'chromatography': [2360], '10-fold': [2363], 'MFE-23,': [2371], 'maximum': [2375], '∼10%': [2378], 'ID/g': [2379], 'data': [2406, 2413, 2785, 3075, 3143], 'compare': [2407], 'very': [2408], 'own': [2412], 'experiments': [2423], 'confirm': [2425], 'accumulation.The': [2434], 'complex,': [2451], '(4.8': [2460], 'versus': [2462], '2.7': [2463], 'nm)': [2464], 'FcRn.': [2497], '∼2-fold.': [2526], 'Similar': [2527], 'reported': [2530], 'radioiodinated': [2535], 'mouse': [2536, 3231, 3255, 3338], '39': [2542], 'h': [2543, 2549], '24': [2548], '(18Chaudhury': [2555], 'Mehnaz': [2557], 'Robinson': [2559, 2619], 'J.M.': [2560, 2620], 'Hayton': [2561], 'W.L.': [2562], 'Pearl': [2563], 'D.K.': [2564], 'Roopenian': [2565], 'D.C.': [2566, 2618], 'Anderson': [2567, 2621], 'C.L.': [2568, 2616, 2622], 'Exp.': [2570], 'Med.': [2571, 2851], '2003;': [2572], '197:': [2573], '315-322Crossref': [2574], '(453)': [2577], 'binds': [2581], 'pH-dependent': [2582], '∼5': [2590], 'μm': [2591], 'pH': [2593, 2674, 2700], '6.0': [2594, 2675], '(19Andersen': [2595], 'J.T.': [2596], 'Dee': [2597], 'Qian': [2598], 'Sandlie': [2600], 'Eur.': [2602], 'Immunol.': [2604, 3206, 3325], '36:': [2606], '3044-3051Crossref': [2607], '(104)': [2610], '20Chaudhury': [2613], 'Brooks': [2615], 'Carter': [2617], 'Biochemistry.': [2623], '45:': [2625], '4983-4990Crossref': [2626], '(210)': [2629], 'prerequisite': [2633], 'via': [2639], 'complex': [2645], 'remains': [2651], 'stable': [2652], 'acidic': [2655], 'environment': [2656], 'endosome.': [2659], 'QCM': [2661], 'decreased': [2672], 'measured': [2679], 'those': [2684], 'others': [2687, 2787, 3285], 'single': [2693], 'neutral': [2699], '(21Jonsson': [2701], 'Dogan': [2703], 'Herne': [2705], 'N.': [2706, 3188], 'Abrahmsén': [2707], 'Nygren': [2709, 2755], '21:': [2716], '515-527Crossref': [2717], '(155)': [2720], '22Linhult': [2723], 'Binz': [2725], 'H.K.': [2726], 'Uhlén': [2727, 2757], 'Hober': [2729, 2749], 'Sci.': [2732], '11:': [2734], '206-213Crossref': [2735], '23Johansson': [2741], 'M.U.': [2742], 'Frick': [2743], 'I.M.': [2744], 'Nilsson': [2745], 'Kraulis': [2747], 'P.J.': [2748], 'Jonasson': [2751], 'Linhult': [2753], 'Björck': [2759], 'Drakenberg': [2761], 'Forsén': [2763], 'Wikström': [2765], '277:': [2771], '8114-8120Abstract': [2772], '(82)': [2780], 'Scholar).Our': [2782], 'clearly': [2788], 'N-glycosylation,': [2792], 'pharmacokinetic': [2800, 3094], 'properties': [2801], 'extent.': [2807], 'However,': [2808], 'improvements': [2810], 'dependent': [2815], 'strategy': [2821], 'format': [2827], 'itself,': [2828], 'directly': [2830], 'affects': [2831, 3087], 'stability': [2835], '(24Colcher': [2836], 'Pavlinkova': [2838], 'Beresford': [2840], 'Booth': [2842], 'B.J.': [2843], 'Choudhury': [2844], 'Bastra': [2846], 'Q.': [2848], 'Nucl.': [2850], '1998;': [2852, 2950], '42:': [2853], '225-241PubMed': [2854], '25Borsi': [2857], 'Balza': [2859], 'Bestagno': [2861], 'Castellani': [2863], 'Carnemolla': [2865], 'Biro': [2867], 'Leprini': [2869], 'Sepulveda': [2871], 'Burrone': [2873], 'O.': [2874], 'Neri': [2875], 'Zardi': [2877], 'Int.': [2879], 'Cancer.': [2881], '102:': [2883], '75-85Crossref': [2884], '(299)': [2887], 'it': [2891, 3069], 'likely': [2893], 'valency': [2898], 'factors': [2902], 'vascularization,': [2906], 'vessel': [2907], 'permeability,': [2908], 'kind': [2911], 'its': [2919, 3400], 'density': [2920], 'plays': [2928], 'determinant': [2930], 'role': [2931], '(26Adams': [2934], 'G.P.': [2935, 2956], 'Schier': [2936], 'Marshall': [2938], 'K.': [2939, 3037, 3194, 3196, 3202, 3315, 3363], 'E.J.': [2941], 'McCall': [2942], 'A.M.': [2943, 2984], 'Marks': [2944, 2961], 'J.D.': [2945, 2962], 'Weiner': [2946, 2970], 'L.M.': [2947, 2971], '58:': [2951, 3328], '485-490PubMed': [2952], '27Adams': [2955], 'Tai': [2957], 'McCartney': [2959], 'J.E.': [2960, 3002], 'Stafford': [2963], '3rd,': [2964], 'W.F.': [2965], 'Houston': [2966], 'L.L.': [2967, 3130], 'Huston': [2968], 'J.S.': [2969], 'Clin.': [2972], '12:': [2976], '1599-1605Crossref': [2977], '(87)': [2980, 3213], '28Wu': [2983], 'Chen': [2985], 'W.': [2986, 3024], 'Raubitschek': [2987], 'L.E.': [2990], 'Neumaier': [2991], 'Fischer': [2993], 'Hu': [2995], 'S.Z.': [2996], 'Odom-Maryon': [2997], 'Wong': [2999], 'J.Y.': [3000], 'Shively': [3001], 'Immunotechnology.': [3003], '1996;': [3004], '2:': [3005], '21-36Crossref': [3006], '29Juweid': [3012], 'Neumann': [3014], 'Paik': [3016], 'Perez-Bacete': [3018], 'Sato': [3020], 'Osdol': [3023], 'Weinstein': [3025], 'J.N.': [3026], '1992;': [3029, 3048], '52:': [3030, 3049], '5144-5153PubMed': [3031], '30Shockley': [3034], 'T.R.': [3035], 'Lin': [3036, 3123], 'Nagy': [3038], 'J.A.': [3039], 'Tompkins': [3040], 'R.G.': [3041], 'Yarmush': [3042], 'M.L.': [3043], 'Dvorak': [3044], 'H.F.': [3045], '367-376PubMed': [3050], 'recognizing': [3061], 'context,': [3068], 'noteworthy': [3071], 'experimental': [3074], 'currently': [3077], 'available': [3078, 3262], 'CD3-positive': [3084], 'biodistribution.': [3091], 'physiological-based': [3093], 'model': [3095, 3339], 'suggests': [3096], 'rather': [3098], 'guiding': [3100], 'tissue,': [3107], 'being': [3112], 'dragged': [3113], 'around': [3114], 'system': [3116], '(31Friedrich': [3121], 'S.W.': [3122], 'Stoll': [3125], 'B.R.': [3126], 'Baxter': [3127], 'L.T.': [3128], 'Munn': [3129], 'R.K.': [3132], 'Neoplasia.': [3133], '4:': [3135], '449-463Crossref': [3136], '(44)': [3139], 'Experimental': [3142], 'chimpanzees': [3156], '2': [3161], 'T-cells': [3168], 'beneficial': [3171], 'impact': [3172], '(32Schlereth': [3177], 'Quadt': [3179], 'Lorenczewski': [3185, 3360], 'Prang': [3187], 'Lippold': [3191, 3364], 'Cobb': [3193], 'Brasky': [3195], 'Bargou': [3199], 'Murthy': [3201], 'Immunother.': [3207, 3326, 3381], '55:': [3209, 3383], '503-514Crossref': [3210], 'CEACD3': [3218], 'human-specific': [3224], 'and,': [3225], 'does': [3227], 'bind': [3229], 'complicating': [3234], 'analysis': [3236], 'aspect,': [3239], 'instance': [3241], 'question': [3245], 'answered': [3248], 'respective': [3258], '(2C11)': [3260], '(33Liao': [3263], 'K.W.': [3264], 'Lo': [3265], 'Y.C.': [3266], 'Roffler': [3267], 'S.R.': [3268], 'Gene': [3269], '2000;': [3271], '339-347Crossref': [3273], '(30)': [3276], 'Scholar)': [3278], 'already': [3282], 'antitumor': [3288, 3341, 3462], '(34Amann': [3302], 'Friedrich': [3304], 'Lutterbuese': [3306], 'Vieser': [3308], 'Lorencewski': [3310], 'Petersen': [3312], 'Brischwein': [3314, 3362], 'Kischel': [3318, 3371], 'Schlereth': [3322], '95-109Crossref': [3329], '(33)': [3332], 'immunocompetent': [3337, 3454], 'solid': [3349], 'could': [3351], 'demonstrated': [3353], '(35Schlereth': [3354], 'Kleindienst': [3356], 'Fichtner': [3358], 'da': [3366], 'Silva': [3367], 'Locher': [3369], 'Lutterbüse': [3373], 'Immunol': [3380], '785-796Crossref': [3384], '(45)': [3387], 'therefore': [3393], 'planned': [3394, 3458], 'convert': [3396], 'anti-mouse': [3406], 'molecules.In': [3408], 'superior': [3435], 'prepared': [3441], 'branched': [3448], 'chain.': [3450], 'now': [3457], 'cell-recruiting': [3468], 'elucidate': [3472], 'if': [3473], 'compensates': [3478], 'activation': [3488], 'cytotoxicity': [3491], 'vitro.': [3493], 'area': [3639, 3671], 'curve': [3642, 3674], 'peripheral': [3651, 3683], 'quartz': [3657, 3689], 'microbalance': [3659, 3691], 'methylthiazolyldiphenyl-tetrazolium': [3663, 3695], 'bromide': [3664, 3696], 'wild': [3665, 3697], 'Although': [3699], 'To': [3940], 'DISCUSSIONIn': [4324]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1995233999', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 14}], 'updated_date': '2024-12-12T07:20:23.788984', 'created_date': '2016-06-24'}