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3363, 3368, 3441, 3468, 3600, 3641, 3667, 3732, 3773, 3787, 3805, 3813, 3823, 3875, 3945, 3963, 4038, 4055, 4070, 4072, 4081, 4090, 4099, 4105, 4109, 4155, 4174, 4187, 4201, 4260, 4328, 4331, 4342, 4374, 4395, 4414, 4442], 'cGMP-dependent': [8, 223, 435, 949, 1256], 'protein': [9, 110, 224, 325, 436, 439, 950, 1475, 2082, 2506, 3208, 3213, 4157, 4191, 4225], 'kinase': [10, 55, 111, 225, 270, 326, 437, 440, 951, 1476, 2083], '(PKG)': [11, 226], 'modulation': [14, 175, 229, 390, 481, 1946], 'vascular': [16, 39, 180, 206, 231, 254, 395, 421, 473, 500, 555, 564, 749, 982, 1056, 1072, 1393, 1706, 1899, 1948, 2035, 4073, 4122, 4396], 'smooth': [17, 232, 432, 443, 449, 501, 750, 983], 'muscle': [18, 233, 433, 444, 450, 751, 984], 'cell': [19, 82, 234, 297, 594, 717, 752, 1404, 1493, 1673, 1685, 2819, 2838, 3222, 3369, 3499, 3671, 4082, 4206, 4269, 4308], '(SMC)': [20, 235, 753], 'proliferation': [21, 83, 208, 236, 298, 423, 817, 1058, 1070, 1388, 1405, 1462, 1950, 1980, 2015, 4071], 'and': [22, 81, 148, 191, 209, 213, 237, 296, 363, 406, 424, 428, 479, 488, 514, 563, 596, 598, 651, 691, 714, 872, 937, 986, 1387, 1403, 1459, 1478, 1687, 1951, 1957, 1981, 2020, 2040, 2045, 2080, 2086, 2117, 2122, 2127, 2200, 2343, 2371, 2390, 2462, 2478, 2540, 2609, 2621, 2654, 2682, 2729, 2737, 2754, 2784, 2803, 2813, 2823, 2849, 2879, 2935, 2952, 2969, 2985, 3017, 3051, 3094, 3120, 3184, 3294, 3316, 3327, 3341, 3379, 3397, 3449, 3456, 3483, 3508, 3510, 3530, 3549, 3568, 3616, 3628, 3638, 3685, 3704, 3723, 3756, 3845, 3861, 3893, 3909, 3932, 3952, 3956, 3968, 3991, 4003, 4011, 4022, 4087, 4181, 4184, 4216, 4237, 4408, 4428, 4440, 4450], 'apoptosis': [23, 151, 210, 238, 366, 425, 597, 754, 1681, 1704, 1952, 2022, 3668], 'vivo.': [25, 240], 'This': [26, 241, 583, 2276], 'is': [27, 242, 547, 585, 1960, 3359, 4334], 'attributable,': [28, 243], 'part,': [30, 245, 504, 914], 'to': [31, 53, 189, 246, 268, 404, 626, 920, 954, 1667, 1794, 1944, 1962, 1990, 2037, 2099, 2113, 2243, 2280, 2296, 2311, 2658, 2766, 2852, 2937, 3068, 3346, 3411, 3464, 3488, 3658, 3799, 3816, 4024, 4146, 4336, 4391], 'a': [32, 47, 142, 168, 247, 262, 357, 383, 466, 548, 1255, 1470, 1669, 2101, 2208, 2212, 2237, 2289, 2313, 2369, 2377, 2385, 2544, 2642, 2660, 2743, 2902, 2914, 3069, 3082, 3211, 3227, 3240, 3413, 3465, 3497, 3619, 3664, 4036, 4097, 4128, 4219, 4295, 4324, 4377, 4429], 'rapid': [33, 248], 'decline': [34, 249], 'PKG': [36, 51, 177, 201, 251, 266, 392, 416, 979, 1411, 1894, 1943, 1971, 1992, 2006, 2028, 2102, 3136, 3356, 4118, 4156, 4190, 4202, 4264, 4286, 4300, 4326, 4384, 4417], 'levels': [37, 178, 252, 393, 4154], 'as': [38, 121, 123, 253, 336, 338, 603, 605, 629, 746, 748, 1898, 2368, 2467, 2494, 2690, 3099, 3101, 3361, 3663, 3798, 3810, 4044, 4096, 4228, 4230, 4362, 4364], 'SMC': [40, 62, 181, 207, 255, 277, 396, 422, 1057, 1073, 1251, 1467, 1707, 1805, 1900, 1949, 1979, 1983, 1999, 2036, 4074, 4123, 4163, 4375, 4397], 'are': [41, 256, 1239, 1901, 4042], 'passaged': [42, 257, 1902], 'culture.': [44, 259], 'We': [45, 260, 2001], 'used': [46, 261, 1986, 2279, 2493, 2592, 2733, 3525, 3657, 4127], 'recombinant': [48, 263, 2456, 2490, 4130, 4189, 4224], 'adenovirus': [49, 264, 2457, 4131, 4379], 'encoding': [50, 265, 2379, 4132], '(Ad.PKG)': [52, 267], 'augment': [54, 269, 4117], 'activity': [56, 271, 1993, 2007, 3131, 3138, 3358, 4120, 4259, 4265, 4303, 4327, 4338], 'cultured': [58, 273, 1464, 1995, 3828, 4162], 'rat': [59, 274, 441, 446, 1465, 1996, 2106, 2230, 4367], 'pulmonary': [60, 275, 447, 568, 1997, 2684, 4368], 'artery': [61, 276, 448, 1998], '(RPaSMC).': [63, 278, 2000], 'Incubation': [64, 279], 'Ad.PKG-infected': [66, 97, 130, 281, 312, 345], 'RPaSMC': [67, 98, 154, 282, 313, 369, 2675, 2712, 2739, 2940, 3142, 3372, 3540, 3674, 3826, 4168, 4209, 4272, 4311, 4400, 4443], '(multiplicity': [68, 283], 'infection': [70, 285, 457, 2640, 2761, 3124, 4243], '=': [71, 286, 2957, 3175, 3386, 3556, 3692, 3842, 4177, 4213, 4277, 4291, 4320], '200)': [72, 287], 'with': [73, 141, 156, 167, 288, 356, 371, 382, 567, 587, 599, 1075, 2024, 2415, 2615, 2628, 2649, 2720, 2756, 2888, 2913, 2954, 2977, 3009, 3019, 3032, 3053, 3097, 3144, 3172, 3381, 3422, 3432, 3551, 3576, 3614, 3618, 3687, 3725, 3758, 3837, 3859, 3891, 3895, 3942, 3954, 3972, 4171, 4256, 4274, 4376, 4403, 4445], '8-Br-cGMP': [74, 92, 147, 289, 307, 362, 3876], 'decreased': [75, 290, 1384], 'serum-stimulated': [76, 291], 'DNA': [77, 94, 127, 292, 309, 342, 1385, 1401, 3485, 3512, 3824, 3939, 3982, 3994], 'synthesis': [78, 95, 128, 293, 310, 343, 1386, 1402], 'by': [79, 87, 101, 107, 211, 294, 302, 316, 322, 426, 505, 915, 1408, 1473, 1480, 1953, 2017, 2051, 2120, 2352, 2419, 2551, 2633, 2655, 2844, 3102, 3319, 3352, 3515, 3634, 3764, 3770, 3794, 3904, 3985, 4013, 4053, 4058, 4194, 4420], '85%': [80, 295], 'at': [84, 119, 299, 334, 2058, 2742, 2825, 2832, 2862, 2885, 2901, 3000, 3048, 3115, 3194, 3201, 3310, 3621, 3914, 3979, 3989, 4029, 4142, 4211, 4234, 4289, 4313, 4318, 4405, 4447], 'day': [85, 300], '5': [86, 301, 2746, 2804, 3167, 3925], '74%.': [88, 303], 'The': [89, 304, 463, 492, 975, 1051, 1395, 2191, 2305, 2321, 2332, 2405, 2455, 2587, 2818, 2960, 3108, 3249, 3416, 3559, 3651, 3695, 3718, 3803, 3937, 4223], 'effect': [90, 305, 1238, 1247, 2638], 'on': [93, 308, 1055, 1250, 1399, 1683, 2943, 3677, 4015], 'was': [99, 314, 1252, 2072, 2097, 2196, 2204, 2221, 2278, 2324, 2338, 2410, 2459, 2596, 2631, 2821, 2963, 3089, 3125, 3139, 3350, 3395, 3419, 3462, 3486, 3513, 3533, 3562, 3632, 3648, 3656, 3698, 3721, 3768, 3808, 3940, 3983, 4034, 4051, 4085, 4113, 4140, 4192, 4203, 4226, 4266, 4304, 4418, 4435], 'blocked': [100, 315, 2861], 'KT5823': [102, 317, 1413, 2085, 3729], '(PKG': [103, 318], 'inhibitor),': [104, 319], 'but': [105, 132, 158, 320, 347, 373, 991], 'not': [106, 133, 159, 321, 348, 374, 1479, 4245, 4254, 4371, 4382], 'KT5720': [108, 323, 3438], '(cAMP-dependent': [109, 324], 'inhibitor).': [112, 327], 'A': [113, 328, 2093, 2137, 4107, 4137], 'nitric': [114, 329, 430, 515], 'oxide': [115, 330, 431, 516], '(NO)': [116, 331], 'donor': [117, 332, 1701, 1955], 'compound,S-nitrosoglutathione,': [118, 333], 'concentrations': [120, 335, 1698, 4173], 'low': [122, 337, 3848], '100': [124, 339, 3280, 3921, 4292, 4449], 'nm,': [125, 340], 'inhibited': [126, 341, 1407, 1461, 2014], 'RPaSMC,': [131, 346, 2009], 'uninfected': [135, 161, 350, 376, 3092], 'cells': [136, 139, 162, 165, 188, 351, 354, 377, 380, 403, 487, 2414, 2466, 2648, 2778, 2970, 2988, 3029, 3093, 3095, 3111, 3181, 3398, 3474, 3569, 3608, 3642, 3705, 3738, 3856, 3884, 3896, 4415], 'or': [137, 163, 352, 378, 569, 1679, 3304, 3383, 3428, 3437, 3439, 3553, 3592, 3598, 3689, 3728, 3730, 3777, 3839, 3873], 'infected': [140, 155, 166, 355, 370, 381, 2755, 2953, 3096, 3143, 3171, 3380, 3550, 3686, 3836, 4170, 4210, 4273, 4312, 4444], 'control': [143, 169, 358, 384, 4378], 'adenovirus.': [144, 170, 359, 385], 'In': [145, 360, 624, 1242], 'addition,': [146, 361], 'S-nitrosoglutathione': [149, 364, 452], 'induced': [150, 365, 2016], 'serum-deprived': [153, 368], 'Ad.PKG,': [157, 372], 'These': [171, 386, 1429, 2047], 'results': [172, 387, 1430, 1809], 'demonstrate': [173, 388], 'that': [174, 389, 1067, 1381, 1457, 1696, 2003, 4249], 'can': [182, 397], 'alter': [183, 398], 'sensitivity': [185, 400, 2033], 'these': [187, 194, 402, 409, 2594, 3442, 3733], 'NO': [190, 212, 405, 427, 647, 911, 960, 1054, 1068, 1249, 1458, 1486, 1665, 1691, 1700, 1954, 2044], 'cGMP.': [192, 214, 407, 429, 2046], 'Moreover,': [193, 408, 2027], 'observations': [195, 410], 'suggest': [196, 411], 'an': [197, 412, 588, 630, 2889, 2928, 3795, 4424], 'important': [198, 413], 'role': [199, 414, 468, 628, 1484, 1797, 1969], 'for': [200, 415, 1236, 2054, 2249, 2447, 2557, 2593, 2769, 2781, 2829, 2865, 2882, 2997, 3198, 3313, 3408, 3526, 3537, 3579, 3879, 3911, 3976, 4026, 4062, 4075, 4239], 'regulation': [204, 419, 471, 1974], 'cell(s)': [434, 445, 451], 'cAMP-dependent': [438, 1474], 'aortic': [442, 1466], 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1879, 1929, 2130, 2155, 2571, 3266, 4350], 'Cardiol.': [522, 612], '1997;': [523, 613, 1038, 1138, 1208, 1319, 1372, 1421, 1575, 1595, 1614, 1637, 1657, 1783, 1885], '79:': [524, 614, 766, 1511, 1719, 1821], '3-8Abstract': [525, 615], 'Full': [526, 616, 847, 1041, 1043, 1107, 1287, 1640, 2161, 2577, 2579, 3272, 4356], 'Text': [527, 617, 848, 1042, 1044, 1108, 1288, 1641, 2162, 2578, 2580, 3273, 4357], 'PDF': [528, 618, 849, 1045, 1109, 1289, 1642, 2163, 2581, 3274, 4358], 'PubMed': [529, 542, 578, 619, 663, 684, 709, 741, 768, 788, 814, 828, 850, 867, 886, 906, 970, 1046, 1088, 1110, 1127, 1141, 1160, 1175, 1194, 1211, 1227, 1268, 1290, 1307, 1322, 1341, 1356, 1375, 1424, 1452, 1513, 1533, 1559, 1578, 1598, 1617, 1643, 1660, 1721, 1741, 1767, 1786, 1823, 1843, 1869, 1888, 1916, 1935, 2164, 2186, 2271, 2400, 2435, 2535, 2582, 3161, 3275, 4359], 'Scopus': [530, 579, 620, 664, 685, 710, 742, 769, 789, 829, 851, 868, 887, 907, 971, 1047, 1089, 1111, 1128, 1142, 1176, 1228, 1269, 1291, 1308, 1323, 1357, 1376, 1425, 1514, 1534, 1579, 1599, 1618, 1644, 1661, 1722, 1742, 1787, 1824, 1844, 1889, 1917, 1936, 2187, 2272, 2401, 2436, 2536, 2583, 2708, 3162], '(141)': [531, 621, 1645], 'Google': [532, 543, 581, 622, 645, 666, 687, 712, 744, 771, 791, 815, 831, 853, 870, 889, 909, 973, 1021, 1049, 1091, 1113, 1130, 1144, 1161, 1178, 1195, 1212, 1230, 1271, 1293, 1310, 1325, 1342, 1359, 1378, 1427, 1453, 1516, 1536, 1560, 1581, 1601, 1620, 1646, 1663, 1724, 1744, 1768, 1789, 1826, 1846, 1870, 1891, 1919, 1938, 2165, 2189, 2274, 2403, 2438, 2538, 2585, 2710, 3164, 3276, 4360], 'Scholar,': [533, 667, 772, 792, 832, 854, 890, 1022, 1092, 1114, 1145, 1162, 1179, 1196, 1213, 1272, 1294, 1311, 1326, 1343, 1517, 1537, 1561, 1582, 1602, 1621, 1647, 1725, 1745, 1769, 1827, 1847, 1871, 1920, 2148, 2166], '2Dzau': [534], 'V.J.': [535, 726], 'Gibbons': [536, 761, 1506, 1714, 1816], 'Hypertension.': [538], '1991;': [539, 642, 706, 3158], '18:': [540], 'III115-III121Crossref': [541], 'Scholar).': [544, 582, 623, 910, 946, 974, 1050, 1360, 1428, 1664, 1790, 1892, 2190, 2275, 2404, 2439, 2487, 2586, 2711, 3165], 'Endothelial': [545], 'dysfunction': [546, 584], 'shared': [549, 2119], 'process': [550], 'pathogenesis': [553], 'disorders,': [556], 'atherosclerosis,': [558], 'neointima': [559], 'formation': [560], 'after': [561, 2639, 2967, 3079, 3123, 3566, 3702, 3853, 4198, 4242], 'angioplasty,': [562], 'remodeling': [565], 'associated': [566, 586, 2023], 'systemic': [570], 'hypertension': [571], '(3Ross': [572], 'R.': [573, 720, 860, 892, 1120, 1198, 1300], 'Nature.': [574], '1993;': [575, 967], '362:': [576], '801-809Crossref': [577], '(10004)': [580], 'alteration': [589], 'balance': [592, 1977], 'growth': [595, 1391], 'dysregulation': [600], 'cell-cell': [602], 'well': [604, 747, 3100, 4363], 'cell-matrix': [606], 'addition': [625], 'its': [627, 2201], 'endothelium-derived': [631], 'relaxing': [632], 'factor': [633], '(4Moncada': [634], 'S.': [635, 658, 673, 679, 704, 796, 806, 838, 1028, 1098, 1278, 1541, 1551, 1584, 1604, 1749, 1759, 1851, 1861, 2530], 'Palmer': [636, 655, 670], 'R.M.': [637, 656, 671], 'Higgs': [638], 'E.A.': [639], 'Pharmacol.': [640, 863, 1017, 1123, 1171, 1303, 1352], 'Rev.': [641, 2702], '43:': [643], '109-142PubMed': [644], 'Scholar),': [646, 688, 713, 816, 871, 1231, 1454, 1939, 2539, 3277], 'regulates': [648], 'platelet': [649], 'adhesion': [650], 'aggregation': [652], '(5Radomski': [653], 'M.W.': [654, 669], 'Moncada': [657, 672], 'Lancet.': [659], '1987;': [660], '2:': [661], '1057-1058Abstract': [662], '(1234)': [665], '6Radomski': [668], 'Proc.': [674, 699, 2525], 'Natl.': [675, 700, 2526], 'Acad.': [676, 701, 2527], 'Sci.': [677, 2528], 'U.': [678, 703, 1588, 2176, 2261, 2510, 2529], 'A.': [680, 705, 821, 1026, 1081, 1261, 1629, 2524, 2531], '1990;': [681, 864, 1124, 1304], '87:': [682], '5193-5197Crossref': [683], '(1132)': [686], 'leukocyte': [689], 'recruitment': [690], 'activation': [692, 718, 1802], '(7Kubes': [693], 'P.': [694, 722, 1024, 1030, 1908], 'Suzuki': [695], 'M.': [696, 760, 778, 858, 1118, 1298, 1505, 1523, 1608, 1713, 1731, 1815, 1833, 2168, 2253], 'Granger': [697], 'D.N.': [698], 'Aci.': [702], '88:': [707], '4651-4655Crossref': [708], '(2822)': [711], 'cytokine-induced': [715], 'endothelial': [716], '(8Decatarina': [719], 'Libby': [721], 'Peng': [723], 'H.-B.': [724], 'Thannickai': [725], 'Rajavashisth': [727], 'T.B.': [728], 'Gimbrone': [729], 'M.A.': [730], 'Shin': [731], 'W.S.': [732], 'Liao': [733], 'J.K.': [734, 2518], 'Clin.': [736, 823, 881, 1083, 1263], 'Invest.': [737, 824, 882, 1084, 1264], '1995;': [738, 883, 1157, 1172, 1338, 1353], '96:': [739, 884], '60-68Crossref': [740], '(1586)': [743], 'Scholar)': [745, 1379, 4361], '(9Pollman': [755, 1500, 1708, 1810], 'M.J.': [756, 1501, 1709, 1811, 2522], 'Yamada': [757, 1502, 1710, 1812], 'T.': [758, 798, 800, 808, 856, 1116, 1296, 1503, 1543, 1545, 1553, 1711, 1751, 1753, 1761, 1813, 1853, 1855, 1863, 2134, 2180, 2265, 2512], 'Horiuchi': [759, 1504, 1712, 1814], 'Circ.': [763, 901, 1508, 1593, 1716, 1818], 'Res.': [764, 783, 902, 1509, 1528, 1594, 1717, 1736, 1819, 1838, 1931], '1996;': [765, 785, 811, 903, 1510, 1530, 1556, 1718, 1738, 1764, 1820, 1840, 1866, 2397, 2574], '748-756Crossref': [767, 1512, 1720, 1822], '(314)': [770, 1515, 1723, 1825], '10Nishio': [773, 1518, 1726, 1828], 'E.': [774, 1011, 1183, 1441, 1519, 1623, 1727, 1829], 'Fukushima': [775, 1520, 1728, 1830], 'K.': [776, 794, 834, 1094, 1274, 1521, 1539, 1571, 1729, 1747, 1779, 1831, 1849, 1881, 3936], 'Shiozaki': [777, 1522, 1730, 1832], 'Watanabe': [779, 1524, 1732, 1834], 'Y.': [780, 802, 804, 836, 842, 1096, 1102, 1276, 1282, 1525, 1547, 1549, 1733, 1755, 1757, 1835, 1857, 1859], 'Biochem.': [781, 1222, 1526, 1734, 1836], 'Biophys.': [782, 1527, 1573, 1735, 1781, 1837, 1883], 'Commun.': [784, 1529, 1737, 1839], '221:': [786, 1531, 1739, 1841], '163-168Crossref': [787, 1532, 1740, 1842], '(93)': [790, 1535, 1743, 1845], '11Fukuo': [793, 1538, 1746, 1848], 'Hata': [795, 1540, 1748, 1850], 'Suhara': [797, 1542, 1750, 1852], 'Nakahashi': [799, 1544, 1752, 1854], 'Shinto': [801, 1546, 1754, 1856], 'Tsujimoto': [803, 1548, 1756, 1858], 'Morimoto': [805, 1550, 1758, 1860], 'Ogihara': [807, 1552, 1760, 1862], 'Hypertension': [809, 1554, 1762, 1864, 1911], '(Dallas).': [810, 1555, 1763, 1865, 1912], '27:': [812, 1557, 1765, 1867], '823-826Crossref': [813, 1558, 1766, 1868], '(12Garg': [818, 1078, 1258], 'U.C.': [819, 1079, 1259], 'Hassid': [820, 1080, 1260], '1989;': [825, 844, 1085, 1104, 1265, 1284, 2158, 2183, 2268, 2705, 4353], '83:': [826, 1086, 1266], '1774-1777Crossref': [827, 1087, 1267], '(1997)': [830, 1090, 1270], '13Kariya': [833, 1093, 1273], 'Kawahara': [835, 1095, 1275], 'Araki': [837, 1097, 1277], 'Fukuzaki': [839, 1099, 1279], 'H.': [840, 1100, 1280, 3261], 'Takai': [841, 1101, 1281], 'Atherosclerosis.': [843, 1103, 1283], '80:': [845, 1105, 1285], '143-147Abstract': [846, 1106, 1286], '(131)': [852, 1112, 1292], '14Nakaki': [855, 1115, 1295], 'Nakayama': [857, 1117, 1297], 'Kato': [859, 1119, 1299], 'Eur.': [861, 1121, 1301], '189:': [865, 1125, 1305], '347-353Crossref': [866, 1126, 1306], '(241)': [869, 1129, 1309], 'migration': [873], '(15Dubey': [874], 'R.K.': [875], 'Jackson': [876], 'E.K.': [877], 'Luscher': [878], 'T.F.': [879], '141-149Crossref': [885], '(301)': [888], '16Sarkar': [891], 'Meinberg': [893], 'E.G.': [894], 'Stanley': [895, 1201], 'J.C.': [896, 1202], 'Gordon': [897, 1199], 'D.': [898, 1200, 2174, 2259, 2553], 'Webb': [899, 1203], 'R.C.': [900, 1204], '78:': [904], '225-230Crossref': [905], '(357)': [908], 'acts,': [912], 'stimulating': [916, 1680], 'soluble': [917], 'guanylate': [918], 'cyclase': [919], 'produce': [921, 2312], 'intracellular': [923], 'second': [924, 2290], 'messenger': [925], 'cGMP': [926, 947, 994, 1398, 1460, 1799, 1958, 3309], '(17Hobbs': [927], 'A.J.': [928], 'Ignarro': [929], 'L.J.': [930], 'Zapol': [931], 'W.M.': [932], 'Bloch': [933], 'K.D.': [934], 'Nitric': [935], 'Oxide': [936], 'Lung.': [939], 'Marcel': [940], 'Dekker,': [941], 'Inc.,': [942, 2483, 3061, 3248, 3493], 'New': [943], 'York1997:': [944], '1-57Google': [945], 'activates': [948], '(PKG),': [952], 'leading': [953], 'many': [955], 'effects': [958, 1052, 1396, 2042], '(18Lincoln': [961], 'T.M.': [962, 1187, 1445, 1906, 1928, 4349], 'Cornwell': [963, 1435, 1909], 'T.L.': [964, 1181, 1439, 1910, 1922, 4347], 'FASEB': [965], '7:': [968], '328-338Crossref': [969], '(543)': [972], 'two': [976, 2306], 'isoforms': [977], 'detected': [980, 2450, 4436], '(Iα': [985], 'Iβ)': [987], 'share': [988], 'substrate-binding/catalytic': [989], 'domains,': [990], 'differ': [992, 1431], 'affinity': [995], '(19Sekhar': [996], 'K.R.': [997], 'Hatchett': [998], 'R.J.': [999, 2508], 'Shabb': [1000], 'J.B.': [1001], 'Wolfe': [1002, 3152], 'L.': [1003, 2150, 2473, 2514, 3153], 'Francis': [1004, 1564, 1772, 1874, 2153, 3254], 'S.H.': [1005, 2154, 3151, 3255], 'Wells': [1006], 'J.N.': [1007], 'Jastorff': [1008], 'B.': [1009, 2354], 'Butt': [1010], 'Chakinala': [1012], 'M.M.': [1013, 1149, 1330], 'Corbin': [1014, 2151, 3154, 3264], 'J.D.': [1015, 2152, 3155, 3265], 'Mol.': [1016], '1992;': [1018, 1224, 3269], '42:': [1019], '103-108PubMed': [1020], '20Ruth': [1023], 'Pfeifer': [1025], 'Kamm': [1027], 'Klatt': [1029], 'Dostmann': [1031], 'W.R.': [1032], 'Hofmann': [1033], 'F.': [1034, 2421], 'Biol.': [1036, 1655, 2156, 2572, 3267, 4351], 'Chem.': [1037, 1656, 2157, 2573, 3268, 4352], '272:': [1039, 1209, 1658], '10522-10528Abstract': [1040], '(58)': [1048], 'been': [1060, 1497], 'extensively': [1061, 1498], 'investigated.': [1062], 'Although': [1063], 'several': [1064], 'studies': [1065, 2595], 'established': [1066], 'decreases': [1069, 1897], 'stimulated': [1074], 'various': [1076, 4406], 'mitogens': [1077], 'Scholar,21Yu': [1131], 'S.M.': [1132, 1313, 1366, 1415, 2178, 2263], 'Hung': [1133, 1314, 1367, 1416], 'L.M.': [1134, 1315, 1368, 1417, 3263], 'Lin': [1135, 1316, 1369, 1418], 'C.C.': [1136, 1317, 1370, 1419], 'Circulation.': [1137, 1318, 1371, 1420], '95:': [1139, 1320, 1373, 1422, 2533], '1269-1277Crossref': [1140, 1321, 1374, 1423], '(179)': [1143, 1324, 1377, 1426], '22Guo': [1146, 1327], 'J.P.': [1147, 1328], 'Panday': [1148, 1329], 'Consigny': [1150, 1331], 'P.M.': [1151, 1332], 'Lefer': [1152, 1333], 'A.M.': [1153, 1334, 1592, 1610], 'Physiol.': [1156, 1190, 1207, 1337, 1448], '269:': [1158, 1339], 'H1122-H1131Crossref': [1159, 1340], '23Mooradian': [1163, 1344], 'D.L.': [1164, 1345], 'Hutsell': [1165, 1346], 'T.C.': [1166, 1347], 'Keefer': [1167, 1348], 'L.K.': [1168, 1349], 'Cardiovasc.': [1170, 1351], '25:': [1173, 1354], '674-678Crossref': [1174, 1355], '(219)': [1177, 1358], '24Cornwell': [1180], 'Arnold': [1182, 1440], 'Boerth': [1184, 1442], 'N.J.': [1185, 1443], 'Lincoln': [1186, 1444, 1927, 4348], '1994;': [1191, 1449, 1913, 1932], '267:': [1192, 1450, 3270], 'C1405-C1413Crossref': [1193, 1451], '25Sarkar': [1197], 'H1810-H1818Crossref': [1210], '26Assender': [1214], 'J.W.': [1215], 'Southgate': [1216], 'K.M.': [1217], 'Hallett': [1218], 'M.B.': [1219, 2568], 'Newby': [1220], 'A.C.': [1221], '288:': [1225], '527-532Crossref': [1226], '(99)': [1229], 'molecular': [1233], 'mechanisms': [1234], 'responsible': [1235], 'this': [1237], 'incompletely': [1240], 'characterized.': [1241], 'most': [1243], 'studies,': [1244], 'antiproliferative': [1246, 2039], 'mediated': [1253, 1472], 'via': [1254, 1469], 'mechanism': [1257, 1471], '21Yu': [1312], 'Recently,': [1361], 'Yu': [1362], 'et': [1363, 1436], 'al.': [1364, 1437], '(21Yu': [1365, 1414], 'observed': [1380], 'cGMP-elevating': [1382], 'agents': [1383], 'epidermal': [1390], 'factor-stimulated': [1392], 'SMC.': [1394], 'both': [1400], 'were': [1406, 2049, 2065, 2089, 2308, 2449, 2492, 2676, 2713, 2732, 2740, 2779, 2842, 2860, 2911, 2925, 2941, 2971, 2989, 3004, 3030, 3076, 3170, 3182, 3224, 3299, 3317, 3335, 3373, 3399, 3451, 3475, 3505, 3524, 3541, 3570, 3583, 3612, 3675, 3706, 3739, 3792, 3827, 3857, 3885, 3902, 3998, 4020, 4101, 4169, 4401], 'selective': [1410], 'inhibitor': [1412], 'from': [1432, 2067, 2074, 2091, 2104, 2217, 2236, 2678, 2764, 3477, 3609, 3785, 3887, 4208, 4271, 4310], 'those': [1433], '(24Cornwell': [1438], 'who': [1455], 'reported': [1456, 1695], '(RASMC)': [1468], '(PKA)': [1477], 'PKG.': [1481], 'Similarly,': [1482], 'induction': [1489], 'apoptotic': [1492, 1982, 3806, 3814], 'death': [1494, 1674, 1806], 'program': [1495], 'has': [1496], 'studied': [1499], '27Zhao': [1562, 1770, 1872], 'Z.': [1563, 1771, 1873], 'C.E.': [1565, 1773, 1875], 'Welch': [1566, 1774, 1876], 'G.': [1567, 1775, 1877, 2564], 'Loscalzo': [1568, 1776, 1878], 'Ravid': [1570, 1778, 1880], 'Biochim.': [1572, 1780, 1882], 'Acta.': [1574, 1782, 1884], '1359:': [1576, 1784, 1886], '143-152Crossref': [1577, 1785, 1887], '(54)': [1580, 1788, 1890], '28Dimmeler': [1583], 'Rippmann': [1585], 'V.': [1586, 2170, 2255], 'Weiland': [1587], 'Haendeler': [1589, 1605], 'Zeiher': [1591, 1609], '81:': [1596], '970-976Crossref': [1597], '(350)': [1600], '29Dimmeler': [1603], 'Nehls': [1607], 'Exp.': [1612], 'Med.': [1613], '185:': [1615], '601-607Crossref': [1616], '(786)': [1619], '30Tzeng': [1622], 'Kim': [1624], 'Y.M.': [1625, 1649], 'Pitt': [1626], 'B.R.': [1627], 'Lizonova': [1628], 'Kovesdi': [1630], 'I.': [1631, 2172, 2257], 'Billiar': [1632, 1652], 'T.R.': [1633, 1653], 'Surgery': [1634], '(St.': [1635], 'Louis).': [1636], '122:': [1638], '255-263Abstract': [1639], '31Kim': [1648], 'Talanian': [1650], 'R.V.': [1651], '31138-31148Crossref': [1659], '(799)': [1662], 'appears': [1666], 'be': [1668, 1963, 4159], 'bifunctional': [1670], 'modulator': [1671], 'capable': [1675], 'either': [1677], 'inhibiting': [1678], 'depending': [1682], 'type': [1686], 'concentration': [1689, 2744, 2903, 3071, 3209, 3467], 'applied.': [1692], 'Several': [1693], 'investigators': [1694], 'high': [1697], 'compounds': [1702, 1956], 'induce': [1703], 'However,': [1791], 'experiments': [1792], 'designed': [1793], 'determine': [1795, 4151], 'programmed': [1804], 'yielded': [1807], 'conflicting': [1808], 'Because': [1893], 'expression': [1895, 4186, 4200], 'rapidly': [1896], 'culture': [1904, 2752, 3417, 3479, 3646, 3672, 3719, 3889], '(32Lincoln': [1905], 'Komalavilas': [1907], '23:': [1914], '1141-1147Crossref': [1915], '(173)': [1918], '33Cornwell': [1921], 'Soff': [1923], 'G.A.': [1924], 'Traynor': [1925], 'A.E.': [1926], 'Vasc.': [1930], '31:': [1933], '330-337Crossref': [1934], '(91)': [1937], 'contribution': [1941], 'analogues': [1959], 'likely': [1961], 'underestimated.': [1964], 'To': [1965, 2206, 3127, 3780, 3819, 4066, 4116, 4150, 4247, 4386], 'further': [1966], 'investigate': [1967], 'death,': [1984], 'we': [1985, 4126], 'adenovirus-mediated': [1987, 2011, 4165, 4285], 'gene': [1988, 2012, 2029, 4166, 4287], 'transfer': [1989, 2030, 4288], 'increase': [1991, 4297], 'report': [2002], 'augmentation': [2004], 'using': [2010, 2109, 2223, 2376, 2451, 2668, 2758, 2927, 3081, 3091, 3146, 3210, 3481, 3496, 4001, 4103, 4164, 4423], 'transfer,': [2013, 4167], 'serum': [2018, 2025, 3044, 3849], 'supplementation': [2019], 'increased': [2021, 2031, 4153, 4217, 4306], 'deprivation.': [2026], 'pro-apoptotic': [2041], 'investigations': [2048], 'approved': [2050], 'Subcommittee': [2053], 'Research': [2055], 'Animal': [2056], 'Massachusetts': [2060], 'General': [2061], 'Hospital.': [2062], 'All': [2063], 'chemicals': [2064], 'purchased': [2066, 2090], 'Sigma,': [2068], 'exceptS-nitrosoglutathione': [2069], '(GSNO),': [2070], 'which': [2071, 2088, 2359, 2497, 2542, 4333], 'obtained': [2073], 'Alexis': [2075], 'Corp.': [2076], '(San': [2077], 'Diego,': [2078, 2330], 'CA),': [2079, 3293], 'inhibitors': [2084, 2792], 'KT5720,': [2087], 'Calbiochem.': [2092], 'polymerase': [2094, 2192, 2669, 4006], 'chain': [2095, 2193, 2670], 'reaction': [2096, 2194, 3229], 'performed': [2098, 4052], 'amplify': [2100, 2659], 'cDNA': [2103, 2214, 2234, 2277, 2291, 2316, 2323, 2445], 'reverse-transcribed': [2105], 'brain': [2107], 'mRNA': [2108], 'degenerate': [2110], 'oligonucleotides': [2111], 'corresponding': [2112], 'amino': [2114, 2297, 4144], 'acids': [2115, 2298], '1–4': [2116], '105–110': [2118], 'bovine': [2121, 3043], 'human': [2123, 2209, 2218, 2250, 2302, 2314, 4134], 'PKG-Iβ': [2124, 2210, 2231, 2251, 2303, 2315, 2322, 2444, 4135], 'isoforms:': [2125], '5′-CCGAATTCAGGAGCATGGGCACCYTGCG-3′': [2126], '5′-CCGGATCCTTTATRAGATCCTTGGA-3′': [2128], '(34Sambrook': [2129], 'Fritsch': [2131], 'E.F.': [2132], 'Maniatis': [2133], 'Molecular': [2135], 'Cloning:': [2136], 'Laboratory': [2138], 'Manual.': [2139], 'Cold': [2140, 2144], 'Spring': [2141, 2145], 'Harbor': [2142], 'Laboratory,': [2143], 'Harbor,': [2146], 'NY1989Google': [2147], '35Wolfe': [2149], '264:': [2159, 4354], '7734-7741Abstract': [2160], '36Sandberg': [2167], 'Natarajan': [2169, 2254], 'Ronander': [2171, 2256], 'Kalderon': [2173, 2258], 'Walter': [2175, 2260], 'Lohmann': [2177, 2262], 'Jahnsen': [2179, 2264], 'FEBS': [2181, 2266], 'Lett.': [2182, 2267], '255:': [2184, 2269], '321-329Crossref': [2185, 2270], '(115)': [2188, 2273], 'product': [2195], 'ligated': [2197, 2309, 2339], 'into': [2198, 2326, 2340, 2412], 'pUC18,': [2199], 'nucleotide': [2202], 'sequence': [2203, 2248], 'determined.': [2205, 3126], 'obtain': [2207], 'cDNA,': [2211], 'λgt11': [2213], 'library': [2215], 'prepared': [2216, 2677], 'placenta': [2219], '(CLONTECH)': [2220], 'screened': [2222], 'a32P-labeled': [2224], 'EcoRI-BamHI': [2225], 'restriction': [2226, 2334], 'fragment': [2227, 2335, 2663], 'cDNA.': [2232], 'One': [2233], 'insert': [2235, 2292], 'hybridizing': [2238], 'bacteriophage': [2239], 'contained': [2240], 'sequences': [2241, 2294], 'identical': [2242, 2295], 'nucleotides': [2244], '22–900': [2245], '(36Sandberg': [2252], 're-screen': [2281], 'library,': [2283], 'resulting': [2284, 2406], 'isolation': [2287], 'containing': [2293, 2442, 2790, 2873, 2994, 3041, 3231, 3405, 3426, 3590, 3712, 3744, 3867, 3920, 4416], '430–3740': [2299], 'sequence.': [2304], 'inserts': [2307], 'atNcoI': [2310], 'specifying': [2317], 'full-length': [2319], 'protein.': [2320, 3371], 'subcloned': [2325], 'pRc/RSV': [2327], '(Invitrogen,': [2328], 'San': [2329, 2560], 'CA).': [2331], 'EcoRI-BglII': [2333], 'pRc/RSV.PKG': [2337], 'NotI': [2342], 'BamHI': [2344], 'sites': [2345], 'vector': [2348, 2408], 'pAd.RSV4': [2349], '(kindly': [2350], 'provided': [2351, 2418, 2550], 'Dr.': [2353, 2420, 2552], 'Davidson,': [2355], 'University': [2356], 'Iowa),': [2358], 'contains': [2360], 'Rous': [2362], 'sarcoma': [2363], 'virus': [2364, 2776, 2961, 3560, 3696], 'long': [2365], 'terminal': [2366], 'repeat': [2367], 'promoter': [2370], 'SV40': [2373], 'polyadenylation': [2374], 'signal,': [2375], 'linker': [2378], 'FLAG': [2381, 4138, 4251, 4433], 'epitope': [2382, 4139], '(DYKDDDDK)': [2383], 'behind': [2384], 'translation': [2386], 'start': [2387], 'site': [2388], '(5′-GGCCGCATGGACTACAAAGACGATGACGACAA-3′': [2389], '5′-AATTTTGTCGTCATCGTCTTTGTAGTCCATGC-3′)': [2391], '(37Chubet': [2392], 'R.G.': [2393], 'Brizzard': [2394], 'B.L.': [2395, 2700], 'BioTechniques.': [2396], '20:': [2398], '136-141Crossref': [2399], '(79)': [2402], 'plasmid': [2407], '(pAd.RSV4.PKG)': [2409], 'cotransfected': [2411], '293': [2413, 2465], 'pJM17': [2416], '(generously': [2417, 2549], 'Graham,': [2422], 'McMaster': [2423], 'University)': [2424], '(38McGrory': [2425], 'W.J.': [2426], 'Bautista': [2427], 'D.S.': [2428], 'Graham': [2429], 'F.L.': [2430, 2471], 'Virology.': [2431], '1988;': [2432], '163:': [2433], '614-617Crossref': [2434], '(550)': [2437], 'Homologous': [2440], 'recombinants': [2441], 'substituted': [2446], 'E1': [2448, 2666], 'RNA': [2452], 'blot': [2453], 'hybridization.': [2454], 'Ad.PKG': [2458, 2757, 2955, 3145, 3173, 3382, 3552, 3688, 3838, 4175, 4275, 4404, 4446], 'expanded,': [2460], 'purified,': [2461], 'titered': [2463], 'described': [2468, 2691, 3148], 'previously': [2469, 2692, 3149], '(39Graham': [2470], 'Prevec': [2472], 'Murray': [2474], 'E.J.': [2475], 'Gene': [2476], 'Transfer': [2477], 'Expression': [2479], 'Protocols.': [2480], 'Humana': [2481], 'Press,': [2482], 'Clifton,': [2484], 'NJ1991:': [2485], '109-128Google': [2486], 'Two': [2488], 'additional': [2489], 'adenoviruses': [2491, 2630], 'controls:': [2495], 'Ad.GFP,': [2496], 'specifies': [2498, 2543], 'EGFP': [2500], 'mutant': [2501], 'green': [2504], 'fluorescent': [2505], '(40Hajjar': [2507], 'Schmidt': [2509], 'Matsui': [2511], 'Guerrero': [2513], 'Lee': [2515, 2695], 'K.H.': [2516], 'Gwathmey': [2517], 'Dec': [2519], 'G.W.': [2520], 'Semigran': [2521], 'Rosenzweig': [2523], '1998;': [2532], '5251-5256Crossref': [2534], '(266)': [2537], 'Ad.βgal,': [2541], 'nuclear-targeted': [2545], 'form': [2546], 'β-galactosidase': [2548], 'Dichek,': [2554], 'Gladstone': [2555], 'Institute': [2556], 'Cardiovascular': [2558], 'Diseases,': [2559], 'Francisco,': [2561], 'CA)': [2562, 4010], '(41Dong': [2563], 'Schulick': [2565], 'A.H.': [2566], 'DeYoung': [2567], 'Dichek': [2569], 'D.A.': [2570], '271:': [2575], '29969-29977Abstract': [2576], '(39)': [2584], 'titer': [2588], 'viral': [2590, 2626, 2650, 3393], 'stocks': [2591, 2627, 2651], '2': [2597, 2770, 2807, 2965, 3390, 3564, 3700, 4027], '×': [2598, 2605, 2611, 2747, 2827, 3168, 3196, 3547, 3682, 3833], '1010': [2599, 2606, 2612], 'units': [2601], '(pfu)/ml': [2602], '(Ad.PKG),': [2603], '1': [2604, 2866, 2883, 3073, 3283, 3469, 3601, 3977], 'pfu/ml': [2607, 2613], '(Ad.GFP),': [2608], '4': [2610, 2833, 3202, 3912], '(Ad.βgal),': [2614], 'particle/pfu': [2616], 'ratios': [2617], '35:1,': [2619], '45:1,': [2620], '38:1,': [2622], 'respectively.': [2623], 'Contamination': [2624], 'replication-competent': [2629], 'excluded': [2632], 'absence': [2635, 3303, 3597, 3872], 'cytopathic': [2637], 'monolayer': [2643], 'A549': [2645], 'lung': [2646], 'carcinoma': [2647], '(20': [2652], 'pfu/cell)': [2653], 'failure': [2657], '200-base': [2661], 'pair': [2662], 'region': [2667], 'reaction.': [2671], 'Primary': [2672], 'cultures': [2673], 'explants': [2679], 'endothelium-': [2681], 'adventitia-stripped': [2683], 'arteries': [2685, 4369], 'adult': [2687], 'Sprague-Dawley': [2688], 'rats': [2689], '(42Yu': [2693], 'F.S.': [2694], 'S.L.': [2696], 'Lanzillo': [2697], 'J.J.': [2698], 'Fanburg': [2699], 'Respir.': [2703], 'Dis.': [2704], '138:': [2706], '1144-1148Crossref': [2707], '(11)': [2709], 'maintained': [2714], 'RPMI': [2716, 2974, 3402, 3423, 3573, 3587, 3709, 3864], '1640': [2717, 2975, 3403, 3424, 3574, 3588, 3710, 3865], 'medium': [2718, 2976, 3404, 3418, 3425, 3575, 3589, 3647, 3711, 3720, 3866], 'supplemented': [2719, 3431, 3724], '10%': [2721], 'NuSerum': [2722, 3407, 3430, 3578, 3594, 3714, 3869], '(Collaborative': [2723], 'Biomedical': [2724], 'Products,': [2725], 'Bedford,': [2726], 'MA),': [2727], 'penicillin,': [2728], 'streptomycin.': [2730], 'Cells': [2731, 3003, 3582, 3901], 'passages': [2735], '3': [2736, 3964], '10.': [2738], 'plated': [2741, 2942, 3374, 3542, 3676], '105': [2748], 'cells/dish': [2749], '60-mm': [2751], 'dishes': [2753, 3480, 3831, 3890], 'multiplicities': [2759], '(m.o.i.)': [2762], 'ranging': [2763], '50': [2765, 4214], '500': [2767, 4182], 'pfu/cell': [2768, 4215], 'h.': [2771, 3581, 3717, 3881], 'After': [2772, 2907, 2980, 3025, 3178, 3204, 3389, 3444, 3471, 3735, 3970], 'removal': [2773], 'suspension,': [2777], 'incubated': [2780, 2881, 2912, 2972, 3018, 3031, 3400, 3585, 3707, 3750, 3846, 3862, 3910, 4402], '48': [2782, 3179, 3409, 3580, 3716, 4235, 4409], 'h': [2783, 2867, 2884, 2966, 3047, 3410, 3565, 3701, 3852, 3913, 3978, 4028, 4197, 4410], 'then': [2785, 2880, 3336, 3506, 3584], 'harvested': [2786, 3183, 3613], 'PEM': [2788, 3190], 'buffer': [2789, 3191, 3919], 'protease': [2791], '(0.1': [2793], 'mmphenylmethylsulfonyl': [2794], 'fluoride,': [2795], '10': [2796, 2799, 2830, 2905, 3199, 3307, 3314], 'μg/ml': [2797, 2800, 2805, 3975], 'leupeptin,': [2798], 'pepstatin': [2801], 'A,': [2802], 'aprotinin),': [2806], 'mm': [2808, 2811, 3331, 3602, 3926], 'EDTA,': [2809, 3927], '15': [2810], '2-mercaptoethanol,': [2812], '20': [2814, 2998, 3232, 3278], 'mmKH2PO4,': [2815], 'pH': [2816, 2871, 3235, 3923], '6.8.': [2817], 'suspension': [2820, 2962, 3394, 3561, 3697], 'homogenized': [2822, 3185], 'centrifuged': [2824, 2837, 3221], '10,000': [2826, 3195], 'g': [2828, 3197], 'min': [2831, 2999, 3200, 3315], '°C.': [2834, 3203, 4031], 'Supernatants': [2835], 'extracts': [2839, 3223, 4207, 4270, 4309, 4341], '(15': [2840], 'μg)': [2841, 3997], 'fractionated': [2843, 4012], '8%': [2845], 'SDS-polyacrylamide': [2846], 'gel': [2847], 'electrophoresis': [2848, 4014], 'electrophoretically': [2850], 'transferred': [2851, 3487], 'nitrocellulose': [2853], 'filters': [2854, 3490], '(Micron': [2855], 'Separations,': [2856], 'Westborough,': [2857], 'MA).': [2858], 'Filters': [2859, 3504], 'room': [2863, 2886, 3001, 3049], 'temperature': [2864, 2887], 'saline,': [2870], '7.4,': [2872, 3236], '5%': [2874, 2995, 3745], 'nonfat': [2875], 'dry': [2876], 'milk': [2877], '(PBS/milk)': [2878], 'anti-FLAG': [2890, 3034, 4425], 'M2': [2891, 3035], 'mouse': [2892], 'monoclonal': [2893, 4426], 'antibody': [2894, 3036, 4427], '(Eastman': [2895], 'Kodak': [2896], 'Co.)': [2897], 'diluted': [2898, 2920, 3065], 'PBS/milk': [2900], 'μg/ml.': [2906, 3074], 'washing,': [2908], 'blots': [2910], 'horseradish': [2915], 'peroxidase-conjugated': [2916], 'anti-mouse': [2917, 3056], 'IgG': [2918, 3057], '(Bio-Rad)': [2919], '1:5000': [2921], 'PBS/milk.': [2923], 'Proteins': [2924], 'visualized': [2926], 'enhanced': [2929], 'chemiluminescence': [2930], 'kit': [2931], '(Amersham': [2932], 'Pharmacia': [2933], 'Biotech)': [2934], 'exposure': [2936], 'x-ray': [2938], 'film.': [2939], 'four-well': [2944, 3678], 'chamber': [2945, 3679], 'slides': [2946, 3680], '(Nalge': [2947], 'Nunc': [2948], 'International,': [2949], 'Naperville,': [2950], 'IL)': [2951], '(m.o.i.': [2956, 3174, 3385, 3555, 3691, 3841, 4176, 4276], '50–500': [2958, 3176], 'pfu/cell).': [2959, 3177, 3388, 3558, 3694, 4279], 'removed': [2964, 3563, 3699], 'infection,': [2968, 3567, 3703, 3854, 4199], '0.1%': [2978, 3020, 3406, 3577, 3713, 3868], 'NuSerum.': [2979], '1,': [2981, 3116, 3624, 4284], '2,': [2982, 3117, 3625], '3,': [2983, 3118, 3626], '5,': [2984, 3119], '7': [2986, 3121, 4240], 'days,': [2987], 'fixed': [2990, 3740], '4%': [2992, 3429, 3593, 3742], 'paraformaldehyde': [2993, 3743], 'sucrose': [2996], 'temperature.': [3002], 'washed': [3005, 3014, 3337, 3507, 3747, 3906], 'PBS,': [3007, 3013, 3016, 3028, 3749, 3908], 'treated': [3008], '1%': [3010, 3042], 'SDS': [3011], 'Triton': [3021], 'X-100': [3022], 'PBS.': [3024], 'washing': [3026, 3328], 'PBS': [3038, 3067, 3860], '(6': [3039], 'μg/ml)': [3040, 3245, 3761], 'albumin': [3045], '(1': [3046, 3760, 3832, 3877, 3996], 'temperature)': [3050], 'subsequently': [3052, 3420, 3999], 'Cy3-conjugated': [3054, 4430], 'rabbit': [3055], '(Jackson': [3058], 'ImmunoResearch': [3059], 'Laboratories,': [3060], 'West': [3062], 'Grove,': [3063], 'PA)': [3064], 'final': [3070, 3466], 'Slides': [3075], 'examined': [3077], 'immediately': [3078], 'preparation': [3080], 'fluorescence': [3083, 3765], 'photomicroscope.': [3084], 'Specificity': [3085], 'immunostaining': [3088], 'ascertained': [3090], 'Ad.βgal': [3098], 'incubation': [3103], 'without': [3104], 'primary': [3106], 'antibody.': [3107, 4432], 'percentage': [3109, 3804, 4413], 'expressing': [3112], 'transgene': [3114, 3134, 4148, 4262], 'days': [3122, 3622, 4241], 'assess': [3128], 'biological': [3130, 4258], 'product,': [3135, 4263], 'enzyme': [3137, 3357, 4119], 'measured': [3140, 3534, 4193, 4267, 4339], 'methods': [3147], '(43Francis': [3150], 'Methods': [3156], 'Enzymol.': [3157], '200:': [3159], '332-341Crossref': [3160], '(30)': [3163], 'Briefly,': [3166], '106cells': [3169], 'h,': [3180, 3391, 3446, 3473, 3737, 4232, 4236], '0.3': [3187], 'ml': [3188], 'before': [3192, 3762, 3958], 'centrifugation': [3193], 'determination': [3205], 'Bradford': [3212], 'assay': [3214], '(Bio-Rad),': [3215], 'supernatants': [3217], '(10': [3218], 'μl)': [3219], 'assayed': [3225], '50-μl': [3228], 'mixture': [3230], 'μm': [3233, 3238, 3281, 3284, 3308], 'Tris,': [3234], '200': [3237, 3557, 3693, 3843, 3930, 4321, 4451], 'ATP,': [3239], 'custom-synthesized': [3241], 'peptide': [3242, 3344, 3364, 4252], 'RKISASEF': [3243], '(136': [3244], '(Genosys': [3246], 'Biotechnologies,': [3247], 'Woodlands,': [3250], 'TX)': [3251], '(44Colbran': [3252], 'J.L.': [3253], 'Leach': [3256], 'A.B.': [3257], 'Thomas': [3258], 'M.K.': [3259], 'Jiang': [3260], 'McAllister': [3262], '9589-9594Abstract': [3271], 'mmMgCl2,': [3279], '3-isobutyl-1-methylxanthine,': [3282], '(R': [3285], 'p)-cAMP-S': [3286], '(Biolog': [3287], 'Life': [3288, 3459], 'Science': [3289, 3460], 'Institute,': [3290], 'La': [3291, 4008], 'Jolla,': [3292, 4009], '30,000': [3295], 'cpm/μl': [3296], '[γ-32P]ATP.': [3297], 'Assays': [3298], 'conducted': [3300], 'presence': [3305, 3599, 3772, 3874, 3962], '30': [3311], '°C': [3312, 3916], 'terminated': [3318], 'transferring': [3320], 'samples': [3321, 3995], 'onto': [3322], 'phosphocellulose': [3323, 3348], 'P-81': [3324], 'paper': [3325, 3349], '(Whatman)': [3326], '75': [3330], 'phosphoric': [3332], 'acid.': [3333], 'Papers': [3334], 'once': [3338], 'ethanol': [3340, 3753], 'dried.': [3342], 'Radiolabeled': [3343], 'bound': [3345], 'quantitated': [3351, 3514, 3984], 'liquid': [3353, 3516], 'scintillation': [3354, 3517], 'spectrometry.': [3355, 3518], 'expressed': [3360], 'nanomoles': [3362], 'phosphorylated': [3365], 'per': [3366], 'min/mg': [3367], 'extract': [3370], '96-well': [3376], 'plates': [3377, 3545], '(103cells/well)': [3378], 'Ad.GFP': [3384, 3554, 3690, 3840], '50–200': [3387], 'removed,': [3396], 'achieve': [3412], 'quiescent': [3414], 'state.': [3415], 'replaced': [3421, 3452, 3722], '0.1': [3427, 3591, 3933], '8-Br-cGMP,': [3433, 3726], 'GSNO,': [3434, 3727], '8-Br-cAMP,': [3435], 'KT5823,': [3436], 'combinations': [3440, 3731], 'reagents.': [3443, 3734], '24': [3445, 3736, 3880, 4231], 'media': [3448], 'reagents': [3450], 'each': [3454, 3520, 3527, 3538, 3605, 3786, 4076], 'well,': [3455], '[3H]thymidine': [3457, 3531], '(NEN': [3458], 'Products)': [3461], 'added': [3463], 'μCi/ml.': [3470], '12': [3472], 'dissociated': [3476], 'trypsin,': [3482], 'radiolabeled': [3484], 'micro-glass-fiber': [3489], '(Cambridge': [3491, 3501], 'Technology,': [3492], 'Watertown,': [3494], 'MA)': [3495], 'PHD': [3498], 'harvester': [3500], 'Technology': [3502], 'Inc.).': [3503], 'dried,': [3509], '[3H]thymidine-labeled': [3511], 'For': [3519, 3604], 'experiment,': [3521], '8–12': [3522], 'wells': [3523, 3611], 'experimental': [3528, 3606], 'condition,': [3529, 3607], 'incorporation': [3532], 'duplicate': [3536], 'well.': [3539], 'six-well': [3544], '(2': [3546, 3681], '104cells/well)': [3548], 'growth-arrested': [3571], '8-Br-cGMP.': [3603], 'three': [3610, 4039], 'trypsin': [3615, 3892], 'counted': [3617], 'hemocytometer': [3620], '0,': [3623], '4,': [3627], '5.': [3629], 'Cell': [3630], 'viability': [3631], 'assessed': [3633], 'trypan': [3635], 'blue': [3636], 'exclusion,': [3637], 'number': [3640], 'floating': [3643, 3897], 'determined': [3649, 4419], 'daily.': [3650], 'DNA-binding': [3652], 'dye': [3653], 'Hoechst': [3654], 'H33258': [3655, 3759], 'define': [3659], 'nuclear': [3660, 3774, 3778], 'chromatin': [3661, 3775], 'morphology': [3662], 'quantitative': [3665], 'index': [3666], 'within': [3669], 'system.': [3673], '104': [3683], 'cells/well)': [3684], 'during': [3715], 'sucrose,': [3746], '95%': [3752], '(3': [3754], 'min),': [3755], 'stained': [3757], 'examination': [3763], 'microscopy.': [3766], 'Apoptosis': [3767], 'defined': [3769], 'condensation': [3776], 'fragmentation.': [3779], 'quantify': [3781], 'apoptosis,': [3782], '300': [3783], 'nuclei': [3784, 3807, 3815], 'five': [3788], 'random': [3789], 'microscopic': [3790], 'fields': [3791], 'analyzed': [3793], 'observer': [3796], 'blinded': [3797], 'treatment': [3801, 3971, 4077], 'group.': [3802], 'calculated': [3809], 'ratio': [3812], 'total': [3817], 'nuclei.': [3818], 'analyze': [3820], 'pattern': [3822], 'fragmentation,': [3825], '10-cm': [3830], '106': [3834], 'cells/plate),': [3835], 'pfu/cell),': [3844, 4183], 'under': [3847], 'conditions.': [3850], 'Forty-eight': [3851, 4196], 'rinsed': [3858], 'mm)': [3878], 'Subsequently,': [3882], 'adherent': [3883], 'detached': [3886], 'pooled': [3894], 'supernatant.': [3900], 'pelleted': [3903], 'centrifugation,': [3905], '37': [3915, 3980], 'lysis': [3918], 'mmTris,': [3922], '8.5,': [3924], '0.2%': [3928], 'SDS,': [3929], 'mmNaCl,': [3931], 'mg/ml': [3934], 'proteinase': [3935], 'genomic': [3938], 'precipitated': [3941], '700': [3943], 'μl': [3944], 'isopropyl': [3946], 'alcohol,': [3947], 'resuspended': [3948], 'Tris/EDTA': [3950], 'buffer,': [3951], 'extracted': [3953], 'phenol': [3955], 'chloroform': [3957], 'precipitation': [3959], 'm': [3965], 'sodium': [3966], 'acetate': [3967], 'ethanol.': [3969], 'RNase': [3973], '(12.5': [3974], '°C),': [3981], 'measuring': [3986], 'absorbance': [3988], '260': [3990], '280': [3992], 'nm.': [3993], 'labeled': [4000], '[α-32P]dCTP': [4002], 'Exo−': [4004], 'Klenow': [4005], '(Stratagene,': [4007], '2%': [4016], 'agarose': [4017], 'gels.': [4018], 'Gels': [4019], 'dried': [4021], 'subjected': [4023], 'autoradiography': [4025], '−70': [4030], 'Each': [4032], 'experiment': [4033], 'repeated': [4035], 'minimum': [4037], 'times.': [4040], 'Data': [4041], 'presented': [4043], 'means': [4046], '±': [4047], 'S.D.': [4048], 'Statistical': [4049], 'analysis': [4050, 4054, 4104], 'variance': [4056], 'followed': [4057], "Bonferroni's": [4059], 't': [4060], 'test': [4061], 'post': [4063], 'hoc': [4064], 'analysis.': [4065], 'compare': 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