Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1994751228', 'doi': 'https://doi.org/10.1016/j.nbd.2007.04.018', 'title': 'Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons', 'display_name': 'Blockade of adenosine A2A receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons', 'publication_year': 2007, 'publication_date': '2007-08-01', 'ids': {'openalex': 'https://openalex.org/W1994751228', 'doi': 'https://doi.org/10.1016/j.nbd.2007.04.018', 'mag': '1994751228', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17596953'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.nbd.2007.04.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35878148', 'display_name': 'Neurobiology of Disease', 'issn_l': '0969-9961', 'issn': ['0969-9961', '1095-953X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://estudogeral.uc.pt/bitstream/10316/4713/1/file7590bea3e9674bc3a5f34db3026e2800.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5047266012', 'display_name': 'Carla G. Silva', 'orcid': 'https://orcid.org/0000-0002-1265-7531'}, 'institutions': [{'id': 'https://openalex.org/I76903346', 'display_name': 'University of Coimbra', 'ror': 'https://ror.org/04z8k9a98', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I76903346']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Carla G Silva', 'raw_affiliation_strings': ['Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal.'], 'affiliations': [{'raw_affiliation_string': 'Center for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004-504 Coimbra, Portugal.', 'institution_ids': ['https://openalex.org/I76903346']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042250833', 'display_name': 'Lisiane O. Porciúncula', 'orcid': 'https://orcid.org/0000-0002-9412-4471'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Lisiane O Porciúncula', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017495019', 'display_name': 'Paula M. Canas', 'orcid': 'https://orcid.org/0000-0002-4091-6406'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Paula M Canas', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058867273', 'display_name': 'Catarina R. Oliveira', 'orcid': 'https://orcid.org/0000-0001-6942-4328'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Catarina R Oliveira', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5058483077', 'display_name': 'Rodrigo A. Cunha', 'orcid': 'https://orcid.org/0000-0003-2550-6422'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Rodrigo A Cunha', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.493, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 56, 'citation_normalized_percentile': {'value': 0.883133, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '27', 'issue': '2', 'first_page': '182', 'last_page': '189'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11193', 'display_name': 'Molecular Physiology of Purinergic Signalling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11193', 'display_name': 'Molecular Physiology of Purinergic Signalling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Molecular Mechanisms of Synaptic Plasticity and Neurological Disorders', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11266', 'display_name': 'Role of Microglia in Neurological Disorders', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/staurosporine', 'display_name': 'Staurosporine', 'score': 0.7513427}, {'id': 'https://openalex.org/keywords/neuroprotection', 'display_name': 'Neuroprotection', 'score': 0.453859}, {'id': 'https://openalex.org/keywords/adenosine-a2a-receptor', 'display_name': 'Adenosine A2A receptor', 'score': 0.4419437}], 'concepts': [{'id': 'https://openalex.org/C2779084600', 'wikidata': 'https://www.wikidata.org/wiki/Q5957181', 'display_name': 'Staurosporine', 'level': 4, 'score': 0.7513427}, {'id': 'https://openalex.org/C2778468042', 'wikidata': 'https://www.wikidata.org/wiki/Q273976', 'display_name': 'Blockade', 'level': 3, 'score': 0.7155207}, {'id': 'https://openalex.org/C148762608', 'wikidata': 'https://www.wikidata.org/wiki/Q3748185', 'display_name': 'Hippocampal formation', 'level': 2, 'score': 0.63783324}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.62945855}, {'id': 'https://openalex.org/C2776991684', 'wikidata': 'https://www.wikidata.org/wiki/Q190012', 'display_name': 'Adenosine', 'level': 2, 'score': 0.6068712}, {'id': 'https://openalex.org/C67907053', 'wikidata': 'https://www.wikidata.org/wiki/Q356147', 'display_name': 'Adenosine receptor', 'level': 4, 'score': 0.5023744}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.49581775}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4464155}, {'id': 'https://openalex.org/C2778491162', 'wikidata': 'https://www.wikidata.org/wiki/Q3063865', 'display_name': 'Adenosine A2A receptor', 'level': 5, 'score': 0.4419437}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3917897}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.33145887}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3146701}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.24638316}, {'id': 'https://openalex.org/C195794163', 'wikidata': 'https://www.wikidata.org/wiki/Q420877', 'display_name': 'Protein kinase C', 'level': 3, 'score': 0.15982077}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.1136415}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09605518}], 'mesh': [{'descriptor_ui': 'D058917', 'descriptor_name': 'Adenosine A2 Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010749', 'descriptor_name': 'Phosphoprotein Phosphatases', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019311', 'descriptor_name': 'Staurosporine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016708', 'descriptor_name': 'Synaptophysin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016708', 'descriptor_name': 'Synaptophysin', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014227', 'descriptor_name': 'Triazines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014230', 'descriptor_name': 'Triazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.nbd.2007.04.018', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S35878148', 'display_name': 'Neurobiology of Disease', 'issn_l': '0969-9961', 'issn': ['0969-9961', '1095-953X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/81ad2eb2ffab471e9a4c5fb4c11afec3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10316/4713', 'pdf_url': 'https://estudogeral.uc.pt/bitstream/10316/4713/1/file7590bea3e9674bc3a5f34db3026e2800.pdf', 'source': {'id': 'https://openalex.org/S4306401208', 'display_name': 'Estudo Geral (Universidade de Coimbra)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2802025818', 'host_organization_name': 'Hospitais da Universidade de Coimbra', 'host_organization_lineage': ['https://openalex.org/I2802025818'], 'host_organization_lineage_names': ['Hospitais da Universidade de Coimbra'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://orbi.ulg.ac.be/handle/2268/182543', 'pdf_url': 'https://orbi.uliege.be/bitstream/2268/182543/1/A2A%20staurosporine.pdf', 'source': {'id': 'https://openalex.org/S4306400651', 'display_name': 'Open Repository and Bibliography (University of Liège)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I157674565', 'host_organization_name': 'University of Liège', 'host_organization_lineage': ['https://openalex.org/I157674565'], 'host_organization_lineage_names': ['University of Liège'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17596953', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10316/4713', 'pdf_url': 'https://estudogeral.uc.pt/bitstream/10316/4713/1/file7590bea3e9674bc3a5f34db3026e2800.pdf', 'source': {'id': 'https://openalex.org/S4306401208', 'display_name': 'Estudo Geral (Universidade de Coimbra)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2802025818', 'host_organization_name': 'Hospitais da Universidade de Coimbra', 'host_organization_lineage': ['https://openalex.org/I2802025818'], 'host_organization_lineage_names': ['Hospitais da Universidade de Coimbra'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.59}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 61, 'referenced_works': ['https://openalex.org/W1514719303', 'https://openalex.org/W1551550807', 'https://openalex.org/W155947415', 'https://openalex.org/W1576503935', 'https://openalex.org/W1577751913', 'https://openalex.org/W174450192', 'https://openalex.org/W1912063668', 'https://openalex.org/W1965280907', 'https://openalex.org/W1966550713', 'https://openalex.org/W1968763887', 'https://openalex.org/W1972130056', 'https://openalex.org/W1973583127', 'https://openalex.org/W1982734210', 'https://openalex.org/W1985935029', 'https://openalex.org/W1991323513', 'https://openalex.org/W1995287360', 'https://openalex.org/W1999150386', 'https://openalex.org/W1999525197', 'https://openalex.org/W2002186719', 'https://openalex.org/W2003475014', 'https://openalex.org/W2006681165', 'https://openalex.org/W2008396525', 'https://openalex.org/W2010114986', 'https://openalex.org/W2010345210', 'https://openalex.org/W2011931872', 'https://openalex.org/W2012008959', 'https://openalex.org/W2016036161', 'https://openalex.org/W2019348310', 'https://openalex.org/W2023462778', 'https://openalex.org/W2025752793', 'https://openalex.org/W2028796721', 'https://openalex.org/W2037642077', 'https://openalex.org/W2041878895', 'https://openalex.org/W2049149064', 'https://openalex.org/W2053269045', 'https://openalex.org/W2059891559', 'https://openalex.org/W2060279471', 'https://openalex.org/W2068976528', 'https://openalex.org/W2069855944', 'https://openalex.org/W2073039482', 'https://openalex.org/W2079762064', 'https://openalex.org/W2081791223', 'https://openalex.org/W2094058760', 'https://openalex.org/W2100728233', 'https://openalex.org/W2101919979', 'https://openalex.org/W2105745549', 'https://openalex.org/W2110645708', 'https://openalex.org/W2116449089', 'https://openalex.org/W2117390254', 'https://openalex.org/W2124872060', 'https://openalex.org/W2133785728', 'https://openalex.org/W2135061224', 'https://openalex.org/W2141364712', 'https://openalex.org/W2145529172', 'https://openalex.org/W2153142245', 'https://openalex.org/W2163629140', 'https://openalex.org/W2168334242', 'https://openalex.org/W2170912851', 'https://openalex.org/W278963161', 'https://openalex.org/W2792448780', 'https://openalex.org/W4296025734'], 'related_works': ['https://openalex.org/W3030859185', 'https://openalex.org/W2987313600', 'https://openalex.org/W2883188911', 'https://openalex.org/W2430034614', 'https://openalex.org/W2426680130', 'https://openalex.org/W2062660503', 'https://openalex.org/W1974998794', 'https://openalex.org/W1963861051', 'https://openalex.org/W1382943', 'https://openalex.org/W130088918'], 'abstract_inverted_index': {'Since': [0], 'adenosine': [1], 'A(2A)': [2], 'receptor': [3], '(A(2A)Rs)': [4], 'blockade': [5, 18, 113], 'protects': [6], 'against': [7], 'noxious': [8], 'brain': [9], 'insults': [10], 'involving': [11], 'apoptosis,': [12], 'we': [13], 'directly': [14], 'tested': [15], 'if': [16], 'A(2A)R': [17, 58, 112], 'prevents': [19], 'apoptosis': [20], 'induced': [21], 'by': [22, 55, 85, 106], 'staurosporine': [23], '(STS).': [24], 'Exposure': [25], 'of': [26], 'rat': [27, 99], 'hippocampal': [28, 100], 'neurons': [29, 44], 'to': [30], 'STS': [31, 71, 88], '(30': [32], 'nM,': [33], '24': [34], 'h)': [35, 69], 'decreased': [36, 77, 91], 'neuronal': [37, 74, 117], 'viability': [38], 'while': [39], 'increasing': [40], 'the': [41, 56, 148], 'number': [42], 'apoptotic-like': [43, 116, 124], 'and': [45, 48, 61, 79, 94, 133], 'de-localizing': [46], 'mitochondria': [47], 'cytochrome': [49], 'c': [50], 'immunoreactivities.': [51], 'This': [52, 120], 'was': [53, 83, 104], 'prevented': [54, 84, 105], 'selective': [57], 'antagonists,': [59], 'SCH58261': [60], 'ZM241385': [62], '(50': [63], 'nM).': [64], 'Shorter': [65], 'incubation': [66], 'periods': [67], '(6': [68], 'with': [70, 122, 142], 'caused': [72], 'no': [73], 'loss': [75], 'but': [76], 'synaptophysin': [78], 'MAP-2': [80], 'immunoreactivities,': [81], 'which': [82, 103, 126], 'SCH58261.': [86, 107], 'Furthermore,': [87], '(100': [89], 'nM)': [90], 'MTT': [92], 'reduction': [93], 'increased': [95], 'caspase-3': [96], 'activity': [97], 'in': [98, 140, 147], 'nerve': [101], 'terminals,': [102], 'These': [108], 'results': [109], 'show': [110], 'that': [111], 'inhibits': [114], 'STS-induced': [115], 'cell': [118], 'death.': [119], 'begins': [121], 'an': [123, 130], 'synaptotoxicity,': [125, 139], 'later': [127], 'evolved': [128], 'into': [129], 'overt': [131], 'neurotoxicity,': [132], 'A(2A)Rs': [134], 'effectively': [135], 'control': [136], 'this': [137], 'initial': [138], 'agreement': [141], 'their': [143], 'predominant': [144], 'synaptic': [145], 'localization': [146], 'hippocampus.': [149]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994751228', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-08-14T06:09:22.542769', 'created_date': '2016-06-24'}