Modulation of Cell Growth by the Hepatitis C Virus Nonstructural Protein NS5A

Name: Work Video:
Duration: 3 min 30 s
Nobuyuki Arima; Chien‐Yuan Kao; Thomas Licht; R. Padmanabhan; Yasuyuki Sasaguri; R. Padmanabhan
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'https://openalex.org/W2143162998', 'https://openalex.org/W2147242002', 'https://openalex.org/W2151603470', 'https://openalex.org/W2160425277', 'https://openalex.org/W2170939558', 'https://openalex.org/W2326248279'], 'related_works': ['https://openalex.org/W2764544906', 'https://openalex.org/W2416526030', 'https://openalex.org/W2113993278', 'https://openalex.org/W2031598848', 'https://openalex.org/W2017808300', 'https://openalex.org/W1997643531', 'https://openalex.org/W1994678738', 'https://openalex.org/W1977702358', 'https://openalex.org/W1966383348', 'https://openalex.org/W1963513230'], 'abstract_inverted_index': {'Hepatitis': [0, 192, 384], 'C': [1, 193, 385], 'virus': [2, 194, 386, 2734, 4591], 'nonstructural': [3, 195, 735], 'protein,': [4, 196, 1120], 'NS5A,': [5, 197, 740, 2125, 2165, 4504, 4545], 'is': [6, 198, 400, 574, 716, 824, 868, 1005, 1214, 1787, 1824, 3649, 3786, 4475], 'a': [7, 96, 112, 131, 142, 199, 288, 304, 323, 334, 388, 401, 577, 705, 719, 825, 933, 1058, 1112, 1152, 1229, 1238, 1248, 1252, 1273, 1438, 1601, 1628, 1694, 1699, 1706, 1765, 1819, 1846, 1897, 1906, 1945, 1980, 2134, 2183, 2328, 2470, 2503, 2532, 2554, 2719, 2926, 2967, 3096, 3205, 3293, 3325, 3341, 3356, 3792, 4336, 4449, 4458, 4505, 4518, 4567], 'phosphoprotein': [8, 200, 826], 'produced': [9, 201, 869, 4239], 'from': [10, 202, 1307, 1902, 1905, 1994, 2047, 2199, 2342, 2361, 2423, 2486, 2636, 2828, 3039, 3042, 3315, 3373, 3387, 3510, 3701, 3811, 3955, 3969, 4001, 4135, 4179, 4197], 'the': [11, 14, 28, 61, 78, 89, 104, 135, 147, 168, 177, 189, 203, 206, 220, 253, 270, 281, 296, 327, 339, 360, 369, 381, 391, 397, 553, 805, 874, 957, 1115, 1178, 1208, 1267, 1549, 1589, 1620, 1624, 1654, 1685, 1717, 1729, 1758, 1770, 1790, 1833, 1852, 1995, 2013, 2037, 2048, 2057, 2100, 2130, 2171, 2180, 2192, 2200, 2343, 2353, 2431, 2441, 2516, 2524, 2536, 2600, 2626, 2713, 2744, 2753, 2815, 2859, 2922, 2984, 3005, 3054, 3057, 3133, 3224, 3236, 3316, 3319, 3347, 3351, 3374, 3377, 3382, 3388, 3393, 3407, 3417, 3446, 3451, 3466, 3469, 3487, 3494, 3504, 3525, 3537, 3540, 3550, 3559, 3565, 3571, 3591, 3604, 3608, 3618, 3623, 3631, 3634, 3642, 3656, 3679, 3691, 3702, 3706, 3717, 3734, 3755, 3769, 3797, 3803, 3808, 3812, 3815, 3866, 3880, 3884, 3914, 3917, 3923, 3942, 3956, 3972, 4004, 4028, 4034, 4079, 4086, 4100, 4107, 4113, 4149, 4243, 4280, 4302, 4323, 4362, 4371, 4383, 4421, 4432, 4440, 4466, 4479, 4495, 4514, 4552, 4557, 4578, 4588], 'processing': [12, 204, 3813], 'of': [13, 31, 115, 134, 205, 223, 307, 326, 390, 396, 406, 456, 498, 540, 562, 567, 579, 709, 721, 833, 840, 873, 935, 942, 1052, 1211, 1228, 1231, 1237, 1241, 1266, 1275, 1278, 1288, 1315, 1349, 1440, 1455, 1552, 1591, 1603, 1643, 1646, 1659, 1716, 1732, 1757, 1780, 1821, 1854, 1932, 1940, 1948, 1968, 1983, 2005, 2017, 2027, 2039, 2044, 2059, 2102, 2124, 2138, 2153, 2164, 2176, 2182, 2197, 2223, 2255, 2324, 2421, 2472, 2562, 2602, 2632, 2650, 2756, 2800, 2966, 2970, 2994, 3037, 3059, 3112, 3117, 3135, 3191, 3226, 3275, 3289, 3303, 3313, 3321, 3338, 3343, 3353, 3365, 3371, 3376, 3409, 3423, 3431, 3445, 3491, 3501, 3506, 3528, 3542, 3554, 3575, 3593, 3600, 3612, 3620, 3644, 3681, 3714, 3759, 3763, 3787, 3805, 3807, 3814, 3865, 3916, 3971, 3978, 4003, 4014, 4043, 4050, 4094, 4106, 4117, 4127, 4151, 4185, 4192, 4257, 4284, 4294, 4385, 4423, 4452, 4471, 4482, 4509, 4556, 4580, 4587], 'viral': [15, 207, 556, 724, 806], 'polyprotein': [16, 208, 708, 3816], 'precursor.': [17, 209], 'NS5A': [18, 121, 178, 210, 313, 370, 823, 930, 950, 997, 1053, 1062, 1108, 1149, 1212, 1592, 1639, 1665, 1692, 1718, 1775, 1795, 1841, 1855, 1990, 2040, 2065, 2069, 2154, 2224, 2358, 2543, 2721, 2773, 3228, 3256, 3276, 3290, 3304, 3322, 3354, 3410, 3432, 3457, 3502, 3569, 3594, 3683, 3715, 3764, 3891, 3908, 3938, 3951, 3979, 4015, 4072, 4081, 4095, 4214, 4235, 4258, 4368, 4386, 4424, 4445, 4483, 4581], 'associates': [19, 211, 999, 1150], 'with': [20, 77, 123, 144, 167, 212, 269, 315, 336, 359, 459, 494, 838, 932, 956, 970, 1000, 1064, 1078, 1114, 1151, 1177, 1247, 1299, 1309, 1384, 1390, 1399, 1767, 1777, 1789, 1802, 1818, 1884, 1957, 2082, 2129, 2264, 2327, 2334, 2352, 2430, 2453, 2531, 2596, 2668, 2731, 2743, 2764, 2792, 2804, 2858, 2891, 2963, 2988, 3004, 3019, 3169, 3216, 3443, 3536, 3603, 3651, 3936, 4027, 4033, 4078, 4085, 4099, 4166, 4352, 4457, 4465, 4517, 4533], 'several': [21, 213], 'cellular': [22, 214, 936, 1001, 1153], 'proteins': [23, 157, 215, 349, 743, 937, 1277, 1290, 1297, 3025, 3810, 3868], 'in': [24, 103, 125, 128, 141, 146, 161, 170, 216, 295, 317, 320, 333, 338, 353, 362, 829, 938, 1076, 1245, 1442, 1463, 1554, 1600, 1670, 1705, 1709, 1723, 1736, 1744, 1748, 1764, 1769, 1792, 1804, 1856, 1878, 1944, 1979, 2073, 2096, 2099, 2133, 2170, 2226, 2440, 2674, 2723, 2821, 2944, 3053, 3095, 3157, 3173, 3185, 3258, 3279, 3292, 3324, 3346, 3434, 3450, 3455, 3483, 3486, 3493, 3503, 3539, 3570, 3587, 3607, 3622, 3716, 3728, 3733, 3742, 3751, 3754, 3765, 3818, 3874, 3883, 3922, 4019, 4063, 4074, 4104, 4144, 4188, 4202, 4219, 4227, 4248, 4317, 4330, 4339, 4347, 4439, 4454, 4494, 4513, 4531, 4540, 4551, 4570], 'mammalian': [25, 217, 939, 1446], 'cells,': [26, 218, 940, 1447, 4341], 'and': [27, 44, 53, 68, 100, 118, 127, 130, 154, 183, 219, 236, 245, 260, 292, 310, 319, 322, 346, 375, 555, 593, 723, 732, 734, 741, 835, 947, 964, 1004, 1109, 1222, 1301, 1303, 1312, 1355, 1396, 1445, 1459, 1546, 1558, 1598, 1627, 1635, 1651, 1653, 1698, 1734, 1782, 1807, 1869, 1953, 1971, 2002, 2012, 2023, 2029, 2089, 2149, 2188, 2209, 2257, 2278, 2301, 2350, 2386, 2396, 2408, 2413, 2509, 2528, 2553, 2567, 2654, 2677, 2759, 2783, 2881, 2953, 3086, 3114, 3120, 3148, 3166, 3183, 3194, 3318, 3381, 3476, 3517, 3573, 3827, 3931, 3981, 3988, 3993, 4046, 4052, 4157, 4196, 4231, 4272, 4288, 4301, 4405, 4446, 4484, 4489, 4499], 'biological': [29, 221], 'consequences': [30, 222], 'this': [32, 38, 224, 230, 965, 1008, 1583, 1607, 1660, 1714, 3533, 3699, 3783, 3937, 4576], 'interaction': [33, 225, 966], 'are': [34, 226, 461, 1224, 1269, 1281, 1548, 1645, 4097, 4530], 'currently': [35, 227], 'unknown.': [36, 228, 1217], 'To': [37, 229, 1606, 3222, 3405, 3877], 'end,': [39, 231, 1608], 'five': [40, 232, 1611, 3996], 'stable': [41, 233, 2060, 2203, 3263, 3719, 3903, 3998, 4119], 'NS5A-expressing': [42, 90, 148, 234, 282, 340, 1613, 3046, 3378, 3529, 3997, 4108, 4154, 4285, 4331, 4558], 'murine': [43, 235, 1625], 'human': [45, 64, 91, 149, 162, 237, 256, 283, 341, 354, 1116, 1179, 1647, 1687, 1724, 1738, 1771, 1806, 1834, 2368, 2548, 3928, 4496, 4589], 'cell': [46, 73, 151, 184, 238, 265, 343, 376, 582, 1079, 1219, 1595, 1604, 1614, 1617, 1633, 1640, 1672, 1676, 1688, 1739, 1809, 1837, 1895, 1899, 2061, 2204, 2306, 2325, 2335, 2575, 2627, 2638, 2777, 2923, 3000, 3033, 3047, 3231, 3264, 3413, 3439, 3484, 3710, 3721, 3752, 3825, 3904, 3948, 3965, 3974, 3999, 4007, 4021, 4054, 4109, 4114, 4120, 4137, 4159, 4171, 4194, 4222, 4249, 4261, 4349, 4377, 4389, 4408, 4427, 4472, 4487, 4490, 4526, 4553], 'lines': [47, 239, 1618, 1641, 1673, 1689, 1740, 2062, 3905, 3949, 3966, 4055, 4160], 'were': [48, 158, 240, 350, 1054, 1876, 1974, 2080, 2127, 2144, 2167, 2216, 2261, 2299, 2302, 2309, 2345, 2570, 2582, 2594, 2640, 2666, 2767, 2779, 2854, 2942, 3015, 3061, 3093, 3144, 3160, 3181, 3214, 3266, 3860, 3934, 3959, 3967, 3984, 4009, 4056, 4139, 4304, 4400, 4511], 'established.': [49, 241], 'Tetracycline-regulated': [50, 242], 'NIH3T3': [51, 69, 243, 261, 1626, 1860, 2424, 3259, 3556, 3688, 3703, 4053, 4158, 4205, 4340, 4541], 'cells': [52, 57, 70, 94, 165, 244, 249, 262, 286, 357, 1750, 1773, 1861, 1865, 1871, 1904, 2035, 2071, 2126, 2143, 2166, 2425, 2487, 2581, 2633, 2728, 2762, 3051, 3180, 3380, 3384, 3426, 3436, 3448, 3471, 3530, 3538, 3557, 3567, 3589, 3606, 3625, 3665, 3689, 3736, 3741, 3767, 3820, 3887, 3933, 4045, 4075, 4130, 4206, 4295, 4333, 4357, 4399, 4442, 4453, 4501, 4510, 4542, 4560], 'rat': [54, 246, 1629, 1891, 1910, 3707], 'liver': [55, 164, 247, 356, 492, 499, 1630, 1650, 1726, 1746, 1836, 1867, 1892, 2727, 2761, 2999, 3044, 3708, 4221, 4498], 'epithelial': [56, 248, 1631, 1893, 3709], 'as': [58, 60, 250, 252, 467, 558, 560, 1174, 1176, 2105, 2219, 2304, 2331, 2572, 2682, 2769, 3330, 3396, 3441, 3562, 3564, 4306, 4412], 'well': [59, 251, 559, 1175, 3563], 'constitutive,': [62, 254], 'NS5A-expressing,': [63, 255], 'Chang': [65, 163, 257, 355, 1649, 1725, 1745, 1772, 1835, 1864, 2611, 2726, 2760, 2998, 3043, 3929, 4044, 4193, 4220, 4332, 4497], 'liver,': [66, 258, 3930], 'HeLa,': [67, 259, 1652, 4156], 'all': [71, 263, 1671, 2822, 3806], 'exhibited': [72, 264, 1693], 'growth': [74, 181, 266, 373, 1065, 1668, 1816, 2049, 2576, 3485, 3526, 3753, 3826, 3872, 4115, 4150, 4210, 4250, 4262, 4488, 4537, 4573, 4583], 'retardation': [75, 267, 1669, 1817, 3527, 4584], 'compared': [76, 268, 3442, 3535, 3602, 4026, 4165, 4351, 4464], 'control': [79, 271, 566, 3383, 3470, 3555, 3605, 3624, 3735, 3915, 4128, 4170, 4356, 4467], 'cells.': [80, 272, 1727, 3260, 4290, 4468], 'Cell': [81, 273, 2230, 2615, 3199], 'cycle': [82, 185, 274, 377, 1220, 1596, 1677, 3200, 4390, 4409, 4428, 4473, 4491, 4527, 4554], 'analysis': [83, 275, 2222, 3201, 3401, 3777, 4069, 4411], 'by': [84, 111, 187, 276, 303, 379, 469, 718, 870, 1007, 1056, 1226, 1272, 1680, 1829, 2155, 2234, 2311, 2339, 2451, 2476, 2560, 2729, 2741, 2883, 2933, 2955, 3063, 3074, 3132, 3146, 3154, 3268, 3332, 3398, 3521, 3598, 3774, 3986, 4273, 4375, 4392], 'flow': [85, 277, 1681, 3177, 4274, 4393], 'cytometry': [86, 278], 'indicated': [87, 279, 1663, 2193, 3677, 4147, 4321, 4366], 'that': [88, 176, 280, 368, 703, 827, 1235, 1452, 1543, 1664, 1684, 1814, 2435, 3285, 3444, 3580, 3655, 3678, 3791, 3795, 3802, 3875, 3879, 4148, 4234, 4322, 4367, 4420, 4586], 'epitheloid': [92, 284], 'tumor': [93, 285], 'had': [95, 287], 'reduced': [97, 160, 289, 352, 1778, 3438, 3586, 4329], 'S': [98, 290, 1696, 4460, 4520], 'phase': [99, 291, 1557, 1697, 1702, 2928, 4456, 4461, 4516, 4521], 'an': [101, 293, 580, 586, 698, 3652, 4183], 'increase': [102, 169, 294, 361, 1708, 1791], 'G2/M': [105, 171, 297, 363, 1556, 1701, 1793, 1822, 4515], 'phase,': [106, 298], 'which': [107, 299, 943, 1279, 1644, 1786, 1839, 2381, 2456, 3456, 3864], 'could': [108, 300, 2662], 'be': [109, 140, 301, 332, 804, 1763, 1845, 2663], 'explained': [110, 302], 'p53-dependent': [113, 305], 'induction': [114, 306, 2038, 2936, 3364, 3430], 'p21Waf1/Cip1': [116, 136, 308, 328, 1382, 1456, 1553, 1759, 2412], 'protein': [117, 179, 309, 371, 961, 1068, 1072, 1182, 1213, 1317, 1719, 2041, 2186, 2852, 3038, 3091, 3229, 3257, 3277, 3305, 3411, 3433, 3595, 3658, 3684, 3980, 4016, 4096, 4259], 'mRNA': [119, 311, 1735, 3982, 4102], 'levels.': [120, 312], 'interacts': [122, 314, 931, 1383], 'Cdk1': [124, 153, 316, 345, 1397, 1781, 1803, 2414, 3085], 'vivo': [126, 318], 'vitro,': [129, 321], 'significant': [132, 324, 1707, 1755, 3481, 3749], 'portion': [133, 325], 'was': [137, 329, 951, 1720, 1741, 1760, 1796, 1942, 1998, 2054, 2232, 2317, 2426, 2467, 2484, 2500, 2526, 2802, 2916, 2961, 3002, 3130, 3202, 3296, 3306, 3391, 3459, 3518, 3584, 3596, 3626, 3637, 3685, 3747, 3772, 3821, 3869, 3888, 3894, 3912, 4017, 4161, 4177, 4216, 4236, 4263, 4296, 4327, 4344, 4462, 4547], 'found': [138, 330, 1761, 1798, 4512], 'to': [139, 331, 463, 491, 576, 726, 803, 953, 968, 1587, 1762, 1799, 1844, 1850, 2020, 2178, 2322, 2825, 2851, 3023, 3090, 3254, 3355, 3514, 3641, 3662, 3687, 3697, 3705, 3789, 3824, 3862, 3890, 3897, 4182, 4199, 4213, 4266, 4335, 4381, 4402, 4478], 'complex': [143, 335, 1113, 1246, 1766], 'Cdk2': [145, 337, 1547, 1768, 2397], 'hepatic': [150, 342], 'line.': [152, 344], 'cyclin': [155, 347, 1310, 1400, 1403, 1544, 1783, 2391, 2394], 'B1': [156, 348, 1784, 2395], 'also': [159, 351, 998, 1797, 2217, 2262, 2717, 3548, 3723, 3822, 4162, 4278], 'consistent': [166, 358, 1788, 3650], 'phase.': [172, 364, 1794], 'Our': [173, 365], 'results': [174, 366, 1658, 1812, 3578, 3676, 4142, 4225, 4315, 4418], 'suggest': [175, 367, 1813], 'causes': [180, 372, 1457], 'inhibition': [182, 374, 3873, 4211], 'perturbations': [186, 378], 'targeting': [188, 380, 1826], 'Cdk1/2-cyclin': [190, 382, 1827], 'complexes.': [191, 383], '(HCV),1': [387], 'member': [389], 'positive': [392], 'strand': [393], 'RNA': [394, 701, 808, 2483, 2496, 2737], 'viruses': [395], 'family': [398, 1274], 'Flaviviridae,': [399], 'major': [402], 'etiologic,': [403], 'causative': [404], 'agent': [405], 'non-A,': [407], 'non-B': [408], 'hepatitis': [409, 466], 'worldwide': [410], '(1Choo': [411], 'Q.L.': [412, 431, 763], 'Kuo': [413, 766, 776], 'G.': [414, 429, 598, 767], 'Weiner': [415], 'A.J.': [416], 'Overby': [417], 'L.R.': [418], 'Bradley': [419], 'D.W.': [420], 'Houghton': [421, 778], 'M.': [422, 600, 604, 623, 676, 771, 779, 850, 896, 902, 908, 1196, 1327, 1511, 3240], 'Science..': [423, 655, 1321], '1989;': [424, 450], '244:': [425, 451], '359-362Google': [426], 'Scholar,': [427, 526, 619, 642, 659, 674, 759, 786, 894, 915, 1021, 1033, 1325, 1336, 1419, 1485, 1504, 3843], '2Kuo': [428], 'Choo': [430, 762], 'Alter': [432, 444], 'H.J.': [433], 'Gitnick': [434], 'G.L.': [435, 3667], 'Redeker': [436], 'A.G.': [437], 'Purcell': [438, 519, 677], 'R.H.': [439, 520, 678], 'Miyamura': [440], 'T.': [441, 504, 844, 884, 919, 1131, 1360, 2686, 3836], 'Dienstag': [442], 'J.L.': [443], 'M.J.': [445, 761, 975, 977], 'Stevens': [446], 'C.E.': [447], 'et': [448, 521, 1526], 'al.Science..': [449], '362-364Google': [452], 'Scholar).': [453, 485, 549, 693, 798, 822, 864, 929, 996, 1049, 1107, 1146, 1206, 1263, 1345, 1381, 1436, 1524, 1581, 2120, 2711, 3674, 3856], 'Approximately': [454], '85%': [455], 'persons': [457], 'infected': [458, 2763], 'HCV': [460, 487, 568, 591, 695, 1989, 2357, 2542, 3227, 3682, 3809, 3867], 'estimated': [462], 'develop': [464], 'chronic': [465], 'determined': [468, 4112, 4279], 'persistently': [470], 'elevated': [471], 'serum': [472], 'alanine': [473], 'aminotransferase': [474], 'and/or': [475], 'viremia': [476], '(HCV': [477], 'RNA)': [478], '(3Seeff': [479], 'L.B.': [480], 'Hepatology..': [481, 615, 3852], '1997;': [482, 656, 690, 891, 993, 1018, 1046, 2619, 2912], '26:': [483], '21S-28SGoogle': [484], 'Persistent': [486], 'infection': [488, 592, 2730], 'often': [489], 'leads': [490], 'cirrhosis': [493], 'its': [495, 1561], 'attendant': [496], 'risks': [497], 'cancer': [500, 1874], '(4Kiyosawa': [501], 'K.': [502, 510, 518, 608, 650, 765, 854, 856, 886, 888, 904, 910, 923, 1162, 1412, 3669], 'Sodeyama': [503], 'Tanaka': [505], 'E.': [506, 769], 'Gibo': [507], 'Y.': [508, 512, 516, 846, 880, 917, 1035, 1039, 1086, 1135, 1421, 2901, 2905], 'Yoshizawa': [509], 'Nakano': [511], 'Furuta': [513], 'S.': [514, 534, 688, 848, 852, 882, 898, 900, 921, 1088, 1102, 1192, 1470, 1499, 1934, 1935, 2706, 3248], 'Akahane': [515], 'Nishioka': [517], 'al.Hepatology..': [522], '1990;': [523], '12:': [524], '671-675Google': [525], '5Shih': [527], 'C.': [528, 663, 747, 749, 773, 777, 1515, 3834], 'Tai': [529], 'P.-C.': [530], 'Whitehead': [531], 'W.': [532], 'Hosono': [533], 'Lee': [535, 772, 1185], 'C.-S.': [536, 538], 'Yang': [537, 1130], 'Encyclopedia': [539], 'Cancer': [541, 1923], 'II.': [542], 'Academic': [543], 'Press,': [544], 'Inc.,': [545, 2373, 2404], 'New': [546], 'York1997:': [547], '824-834Google': [548], 'However,': [550, 1207, 3857, 4493, 4539], 'research': [551], 'on': [552, 1594, 2502, 3204, 3230, 3412, 4260, 4388, 4426, 4431, 4486, 4582], 'pathogenesis': [554], 'replication': [557], 'development': [561], 'therapeutic': [563], 'strategies': [564], 'for': [565, 590, 2056, 2093, 2151, 2221, 2469, 2521, 2599, 2625, 2648, 2657, 2772, 2843, 2885, 2937, 2979, 3125, 3298, 3871, 4058, 4407], 'infections': [569], 'has': [570, 800, 1073, 1449], 'been': [571, 801, 945, 1074, 1450], 'limited.': [572], 'This': [573, 3648, 4469], 'attributed': [575], 'lack': [578], 'appropriate': [581], 'culture': [583, 2076, 2588, 2646, 3495, 4299], 'system': [584, 1849, 3238, 3800, 4036, 4434], 'or': [585, 1392, 1402, 1564, 2157, 2212, 2333, 2445, 2464, 2623, 2725, 2795, 2837, 2897, 2997, 3049, 3056, 3068, 3073, 3489, 3610, 3757, 3941, 3952, 4204], 'adequate': [587], 'animal': [588], 'model': [589, 1848], 'propagation': [594], '(6Beard': [595], 'M.R.': [596], 'Abell': [597], 'Honda': [599], 'Carroll': [601], 'A.': [602, 631, 745, 1037, 1489, 2903], 'Gartland': [603], 'Clarke': [605], 'B.': [606, 627, 1198, 1376, 1476], 'Suzuki': [607], 'Lanford': [609, 624], 'R.': [610, 667, 816, 1041, 1160, 1164, 1366, 1429, 2113, 2907], 'Sangar': [611], 'D.V.': [612], 'Lemon': [613], 'S.M.': [614, 652, 751], '1999;': [616, 639, 912, 1104, 1143, 1170], '30:': [617], '316-324Google': [618], '7Hong': [620], 'Z.': [621], 'Beaudet-Miller': [622], 'R.E.': [625, 661], 'Guerra': [626], 'Wright-Minogue': [628], 'J.': [629, 682, 754, 780, 889, 924, 1013, 1016, 1028, 1167, 1186, 1194, 1201, 1257, 2111, 2114, 2688], 'Skelton': [630], 'Baroudy': [632], 'B.M.': [633], 'Reyes': [634], 'G.R.': [635, 1408, 1493], 'Lau': [636], 'J.Y.': [637], 'Virology..': [638, 670, 911, 992, 1142, 3839], '256:': [640], '36-44Google': [641], '8Kolykhalov': [643], 'A.A.': [644], 'Agapov': [645], 'E.V.': [646], 'Blight': [647], 'K.J.': [648], 'Mihalik': [649], 'Feinstone': [651, 750], 'Rice': [653, 752, 1014, 1026, 3848], 'C.M.': [654, 753, 1015, 1027, 3849], '277:': [657], '570-574Google': [658], '9Lanford': [660], 'Sureau': [662], 'Jacob': [664], 'J.R.': [665, 3838], 'White': [666], 'Fuerst': [668], 'T.R.': [669], '1994;': [671, 861, 1342], '202:': [672], '606-614Google': [673], '10Yanagi': [675], 'Emerson': [679], 'S.U.': [680], 'Bukh': [681], 'Proc.': [683, 1097, 1494, 2701, 3243], 'Natl.': [684, 1098, 1495, 2702, 3244], 'Acad.': [685, 1099, 1496, 2703, 3245], 'Sci.': [686, 1100, 1497, 2704, 3246], 'U.': [687, 1101, 1498, 2705, 3247], 'A...': [689, 1103, 1500, 2707, 3249], '94:': [691], '8738-8743Google': [692], 'The': [694, 714, 865, 1264, 1284, 1295, 1346, 1657, 1675, 1889, 1986, 2051, 2296, 2629, 2775, 2958, 3079, 3128, 3141, 3272, 3301, 3336, 3363, 3429, 3499, 3577, 3761, 3926, 3976, 4011, 4090, 4141, 4173, 4224, 4255, 4291, 4314, 4417], 'virion': [696], 'contains': [697], '∼9.5-kilobase': [699], 'single-stranded': [700], 'genome': [702], 'encodes': [704], 'single': [706, 1898], 'precursor': [707, 715, 3817], 'about': [710, 1242], '3010': [711], 'amino': [712], 'acids.': [713], 'processed': [717], 'combination': [720], 'host': [722], 'proteases': [725], 'yield': [727, 2021], 'mature': [728], 'structural': [729], '(C,': [730], 'E1,': [731], 'E2/p7)': [733], '(NS2,': [736], 'NS3,': [737], 'NS4A,': [738], 'NS4B,': [739], 'NS5B)': [742], '(11Grakoui': [744], 'Wychowski': [746], 'Lin': [748, 1369], 'Virol...': [755, 782, 794, 890, 925, 1017, 1029, 1169, 1202], '1993;': [756, 783, 1333, 1378, 1416, 1433], '67:': [757], '1385-1395Google': [758], '12Selby': [760], 'Berger': [764], 'Glazer': [768], 'Eckart': [770], 'Chien': [774], 'D.': [775, 1331, 1340, 1370, 1427, 1431, 1472, 1920, 3832, 3845], 'Gen.': [781, 1168], '74:': [784, 1204], '1103-1113Google': [785], '13Shukla': [787], 'D.D.': [788], 'Hoyne': [789], 'P.A.': [790, 1914], 'Ward': [791], 'C.W.': [792, 2610], 'Arch.': [793], '1995;': [795, 926, 1260, 1501], '140:': [796], '1747-1761Google': [797], 'NS5B': [799, 1110], 'shown': [802, 952, 1451, 3331, 4062, 4143, 4226, 4316], 'RNA-dependent': [807], 'polymerase': [809], '(14Behrens': [810], 'S.E.': [811], 'Tomei': [812], 'L.': [813, 1125, 1513], 'De': [814], 'Francesco': [815], 'EMBO': [817], 'J...': [818, 1259], '1996;': [819, 1322, 1482, 2117, 3840], '15:': [820], '12-22Google': [821], 'exists': [828], 'differentially': [830], 'phosphorylated': [831, 1006, 3142], 'forms': [832], '56': [834], '58': [836], 'kDa': [837, 1244], 'modifications': [839], 'serine': [841], 'residues': [842], '(15Kaneko': [843], 'Tanji': [845, 879], 'Satoh': [847, 881, 897, 920], 'Hijikata': [849, 907], 'Asabe': [851, 899], 'Kimura': [853, 885], 'Shimotohno': [855, 887, 909, 922], 'Biochem.': [857, 1258], 'Biophys.': [858], 'Res.': [859], 'Commun...': [860], '205:': [862], '320-326Google': [863], '58-kDa': [866], 'form': [867, 876, 1111, 2447], 'additional': [871], 'phosphorylation': [872, 1314], '56-kDa': [875], '(16yAsabe': [877], 'S.I.': [878, 1517, 1534, 1574], 'Kaneko': [883, 918], '71:': [892, 1019], '790-796Google': [893], '17Hirota': [895], 'Kohara': [901], 'Tsukiyama-Kohara': [903], 'Kato': [905], 'N.': [906, 1410, 2694], '257:': [913], '130-137Google': [914], '18Tanji': [916], '69:': [927], '3980-3986Google': [928], 'number': [934, 1230, 1439, 2631, 3619, 4293], 'some': [941, 1464, 2418], 'have': [944], 'identified': [946, 1055, 2824], 'partially': [948], 'characterized.': [949], 'interact': [954, 1298, 1800], 'directly': [955, 2337], 'interferon-induced': [958], 'double-stranded': [959], 'RNA-activated': [960], 'kinase': [962, 1003, 1009, 1562, 1566], 'PKR,': [963], 'seems': [967], 'correlate': [969], 'PKR': [971], 'function': [972, 1853], '(19Gale': [973], 'Jr.,': [974], 'Korth': [976], 'Tang': [978], 'N.M.': [979], 'Tan': [980], 'S.L.': [981, 1082], 'Hopkins': [982], 'D.A.': [983], 'Dever': [984], 'T.E.': [985], 'Polyak': [986], 'S.J.': [987, 1414], 'Gretch': [988], 'D.R.': [989, 1129], 'Katze': [990, 1095], 'M.G.': [991, 1096], '230:': [994], '217-227Google': [995], 'serine/threonine': [1002], '(21Reed': [1010], 'K.E.': [1011, 1023], 'Xu': [1012], '7187-7197Google': [1020], '22Reed': [1022], 'Gorbalenya': [1024, 1136], 'A.E.': [1025, 1137], '1998;': [1030, 1521, 1538, 1578, 3671, 3853], '72:': [1031], '6199-6206Google': [1032], '43Ide': [1034], 'Tanimoto': [1036, 2902], 'Sasaguri': [1038, 2904], 'Padmanabhan': [1040, 2112, 2906], 'Gene': [1042, 2908], '(': [1043, 2909], 'Amst.': [1044, 2910], ')..': [1045, 2911], '201:': [1047, 2913], '151-158Google': [1048, 2914], 'Other': [1050], 'interactions': [1051], 'using': [1057, 1619, 2146, 2235, 2491, 2535, 2781, 3209], 'yeast': [1059, 1444], 'two-hybrid': [1060], 'assay.': [1061], 'binding': [1063], 'factor': [1066], 'receptor-bound': [1067], '2': [1069, 2522, 2844], '(Grb2)': [1070], 'adaptor': [1071], 'implicated': [1075], 'interference': [1077], 'signaling': [1080], '(24Tan': [1081], 'Nakao': [1083], 'H.': [1084, 1123, 1425, 2109, 3242], 'He': [1085], 'Vijaysri': [1087], 'Neddermann': [1089], 'P.': [1090, 3847], 'Jacobs': [1091], 'B.L.': [1092], 'Mayer': [1093], 'B.J.': [1094], '96:': [1105], '5533-5538Google': [1106], 'vesicle-associated': [1117], 'membrane': [1118, 2349, 2517, 2525], 'protein-associated': [1119], 'hVAP': [1121], '(25Tu': [1122], 'Gao': [1124], 'Shi': [1126], 'S.T.': [1127], 'Taylor': [1128, 1490], 'Mircheff': [1132], 'A.K.': [1133, 1158], 'Wen': [1134], 'Hwang': [1138], 'S.B.': [1139], 'Lai': [1140], 'M.M.': [1141], '263:': [1144], '30-41Google': [1145], 'In': [1147, 1437, 1582, 2417, 2613, 3782, 4575], 'addition,': [1148], 'transcription': [1154], 'factor,': [1155], 'SRCAP': [1156], '(26Ghosh': [1157], 'Steele': [1159], 'Meyer': [1161], 'Ray': [1163, 1165], 'R.B.': [1166], '80:': [1171], '1179-1183Google': [1172], 'Scholar),': [1173], 'karyopherin': [1180], 'β3': [1181], '(27Chung': [1183], 'K.M.': [1184], 'Kim': [1187], 'J.E.': [1188], 'Song': [1189], 'O.K.': [1190], 'Cho': [1191], 'Lim': [1193], 'Seedorf': [1195], 'Hahm': [1197], 'Jang': [1199], 'S.K.': [1200], '2000;': [1203], '5233-5241Google': [1205], 'physiological': [1209], 'role': [1210], 'still': [1215, 3519, 4237], 'largely': [1216], 'Eukaryotic': [1218], 'progression': [1221, 1597], 'proliferation': [1223, 1599], 'regulated': [1225, 1271], 'activation': [1227], 'cyclin-dependent': [1232], 'kinases': [1233], '(Cdks)': [1234], 'consist': [1236], 'catalytic': [1239], 'subunit': [1240, 1250], '34': [1243], 'cyclin-regulatory': [1249], '(for': [1251], 'review,': [1253], 'see': [1254], 'Ref.': [1255], '28Pines': [1256], '308:': [1261], '697-711Google': [1262], 'activities': [1265], 'Cdks': [1268, 1306, 2823], 'tightly': [1270], 'Cdk-inhibitory': [1276], 'there': [1280, 3746, 4546], 'two': [1282, 1616, 1686, 1830, 2297, 4041, 4189], 'classes.': [1283], 'first': [1285, 2429, 3234, 3307], 'class': [1286, 1348], 'consists': [1287], 'INK4': [1289, 1296], '(p16,': [1291], 'p15,': [1292], 'p18,': [1293], 'p19).': [1294], 'Cdk4': [1300, 1391], 'Cdk6': [1302], 'prevent': [1304, 2179], 'these': [1305, 3280, 4020, 4118, 4123, 4152, 4397], 'interacting': [1308], 'D': [1311, 1388], 'subsequent': [1313, 2321], 'retinoblastoma': [1316], '(pRB)': [1318], '(29Sherr': [1319], 'C.J.': [1320], '274:': [1323], '1672-1677Google': [1324], '30Serrano': [1326], 'Hannon': [1328, 1422], 'G.J.': [1329, 1338, 1423], 'Beach': [1330, 1339, 1430], 'Nature..': [1332, 1341, 1432], '366:': [1334, 1434], '704-707Google': [1335], '31Hannon': [1337], '371:': [1343], '257-261Google': [1344], 'other': [1347, 3467], 'Cdk': [1350], 'inhibitors': [1351], 'includes': [1352], 'p21Waf1/Cip1,': [1353], 'p27Kip1,': [1354], 'p57': [1356], '(32el-Deiry': [1357], 'W.S.': [1358], 'Tokino': [1359], 'Velculescu': [1361], 'V.E.': [1362], 'Levy': [1363], 'D.B.': [1364], 'Parsons': [1365], 'Trent': [1367], 'J.M.': [1368], 'Mercer': [1371], 'W.E.': [1372], 'Kinzler': [1373], 'K.W.': [1374], 'Vogelstein': [1375], 'Cell..': [1377, 1415, 1481], '75:': [1379, 1417], '817-825Google': [1380], 'Cdk-cyclin': [1385], 'complexes': [1386, 1828], '(cyclin': [1387], 'complexed': [1389, 1398], 'Cdk6,': [1393], 'Cdk2-cyclin': [1394], 'E,': [1395], 'A': [1401, 1545, 1754, 2392, 3193, 4146, 4230], 'B': [1404, 4320], '(33Harper': [1405], 'J.W.': [1406], 'Adami': [1407], 'Wei': [1409], 'Keyomarsi': [1411], 'Elledge': [1413], '805-816Google': [1418], '34Xiong': [1420], 'Zhang': [1424], 'Casso': [1426], 'Kobayashi': [1428], '701-704Google': [1435], 'studies': [1441], 'both': [1443, 1737, 1805, 2207, 2384, 2459, 3084, 3473, 4270, 4444], 'it': [1448, 3785, 4343], 'ectopic': [1453], 'expression': [1454, 1593, 1666, 1731, 2123, 2152, 2163, 2181, 2228, 2722, 2746, 3273, 3291, 3352, 3368, 3458, 3500, 3592, 3680, 3693, 3762, 3799, 3804, 3892, 3939, 3977, 4012, 4073, 4215, 4369, 4387, 4425, 4433], 'G1': [1458], 'G2': [1460, 1467], 'arrest': [1461, 1468], 'and,': [1462], 'studies,': [1465], 'predominantly': [1466], '(35Tournier': [1469], 'Leroy': [1471], 'Goubin': [1473], 'F.': [1474], 'Ducommun': [1475], 'Hyams': [1477], 'J.S.': [1478], 'Mol.': [1479, 1518, 1535, 1575], 'Biol.': [1480, 2115, 2617], '7:': [1483], '651-662Google': [1484], '36Agarwal': [1486], 'M.L.': [1487], 'Agarwal': [1488], 'W.R.': [1491], 'Stark': [1492], '92:': [1502], '8493-8497Google': [1503], '37Niculescu': [1505], 'III,': [1506], 'A.B.': [1507], 'Chen': [1508], 'X.': [1509], 'Smeets': [1510], 'Hengst': [1512], 'Prives': [1514], 'Reed': [1516, 1533, 1573], 'Cell.': [1519, 1536, 1576], 'Biol...': [1520, 1537, 1577], '18:': [1522, 1539, 1579], '629-643Google': [1523], 'Dulic': [1525], 'al.(38Dulic': [1527], 'V.': [1528, 1568], 'Stein': [1529, 1569], 'G.H.': [1530, 1570], 'Far': [1531, 1571], 'D.F.': [1532, 1572], '546-557Google': [1540, 1580], 'Scholar)': [1541, 1928, 2622, 2915, 3253], 'proposed': [1542], 'primary': [1550, 2474], 'targets': [1551], 'premitotic': [1555], 'may': [1559], 'inhibit': [1560], 'activity': [1563], 'Cdk-activating': [1565], '(38Dulic': [1567], 'study,': [1584], 'we': [1585, 1609, 2716, 3233, 3415, 3900, 4379], 'sought': [1586, 3696, 4380], 'examine': [1588], 'effect': [1590, 3225, 3408, 3643, 3882, 4256, 4384, 4422, 4579], 'variety': [1602], 'lines.': [1605, 1810, 4110, 4121], 'established': [1610], 'stable,': [1612], 'lines:': [1615], 'tetracycline-regulated': [1621, 2068, 2162, 3237, 3294, 3692, 3718, 3798, 4035], '(Tet-off)': [1622], 'system,': [1623, 2008], '(RLE)': [1632, 1894], 'line,': [1634, 1838, 1896, 3711], 'three': [1636, 3902, 4005], 'constitutively': [1637, 1690, 1751, 2063, 3906, 4502, 4543], 'expressing': [1638, 1691, 1752, 1774, 2064, 3385, 3568, 3907, 3950, 4359, 4443, 4503, 4544], '(two': [1642], 'origin,': [1648], 'third,': [1655], 'NIH3T3).': [1656], 'study': [1661, 1851, 3406, 3794], 'clearly': [1662, 4070], 'caused': [1667], 'examined.': [1674], 'distribution,': [1678], 'analyzed': [1679, 3215], 'cytometry,': [1682], 'showed': [1683, 3286, 3479], 'shortened': [1695, 4519], 'prolonged': [1700], 'progression,': [1703], 'resulting': [1704], 'population': [1710, 3422, 4174, 4372], 'doubling': [1711, 4175, 4373], 'time.': [1712], 'Interestingly,': [1713, 4209], 'property': [1715], 'most': [1721, 4217], 'prominent': [1722, 4218], 'Moreover,': [1728], 'induced': [1730, 3597], 'p21Waf1/Cip1protein': [1733], 'more': [1742, 3994], 'pronounced': [1743], 'than': [1747, 3962, 3995], 'HeLa': [1749, 1870, 2724, 2758, 2996, 3932, 4051, 4203, 4289, 4348, 4500], 'NS5A.': [1753, 4360], 'por-tion': [1756], 'concomitant': [1776], 'levels': [1779, 3274, 3288, 3320, 3983, 4031, 4093, 4103], 'proteins,': [1785], 'specifically': [1801], 'mouse': [1808, 2377, 2551, 2794, 3069], 'These': [1811, 3675, 4525], 'NS5A-mediated': [1815], 'pause': [1820], 'transition': [1823], 'through': [1825], 'mechanisms.': [1831], 'Thus,': [1832], 'expresses': [1840], 'constitutively,': [1842], 'appears': [1843], 'good': [1847], 'liver-specific': [1857], 'gene': [1858, 3367, 3911], 'expression.': [1859, 2774], '(mouse': [1862], 'fibroblasts),': [1863], '(Chang': [1866], 'cells),': [1868], '(human': [1872], 'cervical': [1873], 'cells)': [1875, 2635], 'grown': [1877, 2072, 3052, 3449, 4401], "Dulbecco's": [1879, 1949], 'modified': [1880, 1950], "Eagle's": [1881, 1951], 'medium': [1882, 1952, 1955, 2098, 2172, 3348, 3375, 3452, 3496], 'supplemented': [1883, 1956], '10%': [1885, 1958, 2285, 2678], 'fetal': [1886, 1959], 'bovine': [1887, 1960], 'serum.': [1888, 1961], 'diploid': [1890], 'clone': [1900, 3283, 4048], 'derived': [1901, 1993], 'parental': [1903], '10-day-old': [1907], 'Fischer': [1908], '344': [1909], '(39Huggett': [1911], 'A.C.': [1912], 'Ellis': [1913], 'Ford': [1915], 'C.P.': [1916], 'Hampton': [1917], 'L.L.': [1918], 'Rimoldi': [1919], 'Thorgeirsson': [1921], 'S.S.': [1922], 'Res...': [1924], '1991;': [1925], '51:': [1926], '5929-5936Google': [1927], '(a': [1929, 2359], 'generous': [1930], 'gift': [1931, 2360], 'Dr.': [1933, 2362], 'Thorgeirsson,': [1936], 'NCI,': [1937], 'National': [1938], 'Institutes': [1939], 'Health)': [1941], 'cultured': [1943, 1975, 2656, 2917], '1:1': [1946], 'mixture': [1947, 3100], 'F-12': [1954], 'All': [1962], 'media': [1963], 'contained': [1964], '50': [1965, 2243, 3097, 3102, 3115, 3195], 'μg/ml': [1966, 3116, 3190, 3196], 'each': [1967, 2227, 2254, 2585, 2643, 3040, 3970, 4002, 4049, 4105, 4136], 'penicillin': [1969], 'G': [1970], 'streptomycin.': [1972], 'Cells': [1973, 2260, 2593, 3156], 'at': [1976, 2191, 2488, 2518, 2565, 2590, 2752, 2846, 2918, 2976, 3008, 3122, 3340, 3392], '37': [1977, 2919], '°C': [1978, 2520, 2920, 2978, 3010, 3124], 'humidified': [1981], 'atmosphere': [1982], '5%': [1984], 'CO2.': [1985], 'full-length': [1987], 'wild-type': [1988], 'coding': [1991], 'sequence': [1992], 'HCV-H': [1996], 'strain': [1997, 2889], 'cloned': [1999], 'into': [2000, 2034], 'theSalI': [2001], 'XhoI': [2003], 'sites': [2004, 2016, 2569], 'pTet-Splice': [2006, 3475], '(Tet-off': [2007], 'Life': [2009, 2141], 'Technologies,': [2010], 'Inc.)': [2011], 'EcoRI': [2014], 'andXhoI': [2015], 'pCI-neo': [2018, 2090, 2213, 3924, 3943, 4080, 4087, 4168], '(Promega)': [2019], 'pTet-Splice/NS5A': [2022, 2028, 2083], 'pCI-neo/NS5A,': [2024], 'respectively.': [2025], 'Cotransfection': [2026], 'pTet-tTAK': [2030, 2086, 2210, 2563, 3477], '(Life': [2031, 2494], 'Technologies)': [2032], 'plasmids': [2033, 3478], 'allowed': [2036], 'under': [2042, 3630, 3690, 3768, 3913, 4308, 4414], 'conditions': [2043, 3771], 'tetracycline': [2045, 2177, 2198, 3060, 3314, 3339, 3372, 3454, 3492, 3507, 3543, 3613], 'withdrawal': [2046, 2196, 3312, 3370, 3599], 'medium.': [2050, 2201], 'pCI-neo/NS5A': [2052, 2131], 'plasmid': [2053, 2132, 2564, 2747, 2899, 3940, 3958, 4082], 'used': [2055, 2303, 2468, 2571, 2768, 3235, 3416, 3796], 'generation': [2058], 'protein.': [2066, 3647, 3909], 'For': [2067, 2121, 2161, 2574, 2712, 4122, 4396, 4437], 'expression,': [2070, 3899], '60-mm': [2074, 2644], 'tissue': [2075, 2587, 2645], 'dishes': [2077], '(30–50%': [2078], 'confluence)': [2079], 'cotransfected': [2081], '(5': [2084, 2087], 'μg),': [2085, 2088], '(0.1': [2091], 'μg)': [2092], '6': [2094], 'h': [2095, 2787, 2845, 3163, 3310, 4181, 4187, 4201], 'serum-free': [2097], 'presence': [2101, 3055, 3488, 3541, 3572, 3609, 3756], 'cationic': [2103], 'lipids': [2104], 'previously': [2106, 2684], 'described': [2107, 2683, 4307, 4413], '(40Chen': [2108], 'Campisi': [2110], 'Chem...': [2116], '271:': [2118], '13959-13967Google': [2119], 'constitutive': [2122, 4153], 'transfected': [2128, 3935, 4077], 'similar': [2135], 'way.': [2136], 'Clones': [2137], 'G418': [2139], '(Geneticin;': [2140], 'Technologies)-resistant': [2142], 'isolated': [2145, 3968], 'cloning': [2147], 'rings': [2148], 'screened': [2150, 3267, 3985], 'Western': [2156, 3269, 3333, 3522, 3775, 3987], 'Northern': [2158, 3399, 3989, 4067], 'blot': [2159, 3270, 3334, 3400, 3776, 3990, 4068], 'analysis.': [2160, 3271, 3300, 3335, 4276, 4395], 'continuously': [2168], 'maintained': [2169], 'containing': [2173, 2251, 2948, 3101, 3188, 3453], '500': [2174], 'ng/ml': [2175, 3345], 'tetracycline-controlled': [2184], 'transactivator': [2185], '(tTA)': [2187], 'then': [2189, 2529, 2655, 3167], 'harvested': [2190], 'time': [2194, 4176, 4245, 4374], 'after': [2195, 3164, 3311, 3369, 4240], 'G418-resistant': [2202, 3262, 3947, 4355], 'clones': [2205, 2639, 3048, 3265, 4000, 4022, 4042, 4191, 4350], 'carrying': [2206, 3472, 3558, 3737], 'pTet-splice': [2208], 'vectors': [2211], 'vector': [2214, 3390, 3561, 3739, 3944, 3957, 4088, 4169], 'alone': [2215, 2766], 'generated': [2218], 'controls': [2220, 2771], 'effects': [2225, 4481], 'system.': [2229, 3694], 'extract': [2231, 2801, 3001], 'prepared': [2233, 2485, 2780, 4406], 'Nonidet': [2236, 2249, 2872], 'P-40': [2237], 'lysis': [2238], 'buffer': [2239, 2266, 2280, 2862], '(150': [2240], 'mm': [2241, 2244, 2253, 2268, 2273, 2276, 2288, 2291, 2864, 2869, 2875, 2878, 2950, 3103, 3108], 'NaCl,': [2242, 2876], 'Tris-HCl,': [2245, 2865, 3104], 'pH': [2246, 2270, 2283, 2866, 3105], '8.0,': [2247], '1%': [2248, 2504], 'P-40)': [2250], '1': [2252, 2877, 2934, 2949, 2980, 3361, 3403, 3515, 4038], 'dithiothreitol': [2256], 'phenylmethylsulfonyl': [2258, 2879, 2951], 'fluoride.': [2259], 'lysed': [2263, 2595, 2954], 'H': [2265, 2782], '(20': [2267], 'Hepes-KOH,': [2269], '7.5,': [2271, 2284, 3106], '5': [2272, 2287, 2868, 4253, 4312, 4319], 'KCl,': [2274, 2289], '0.5': [2275, 2290], 'MgCl2)': [2277], 'N': [2279, 2784], '(50': [2281, 2863, 3035], 'mmHepes-KOH,': [2282], 'sucrose,': [2286], 'MgCl2,': [2292, 3109], '0.2': [2293], 'm': [2294], 'NaCl).': [2295], 'fractions': [2298], 'combined': [2300, 4480], 'total': [2305, 2776, 2995], 'lysates.': [2307], 'Proteins': [2308, 2341], 'separated': [2310, 3145], 'SDS-polyacrylamide': [2312], 'gel': [2313, 2508], 'electrophoresis': [2314], '(SDS-PAGE).': [2315], 'Immunoblotting': [2316], 'carried': [2318, 2427], 'out': [2319, 2428], 'either': [2320, 2438, 2892, 3064], 'immunoprecipitation': [2323, 2420, 2714], 'extracts': [2326, 2336, 2422], 'specific': [2329, 3889], 'antibody,': [2330], 'indicated,': [2332], 'fractionated': [2338, 2501, 2882], 'SDS-PAGE.': [2340, 3031], 'SDS-PAGE': [2344, 2884, 3137, 3147], 'electrotransferred': [2346, 3149], 'onto': [2347, 2511, 2584, 2642, 3030, 3150, 4298], 'nitrocellulose': [2348, 2512, 3151], 'probed': [2351], 'monoclonal': [2354, 2432, 2805, 3070], 'antibodies': [2355, 2410], 'against': [2356, 2411, 2814], 'Jade': [2363], 'Chin,': [2364], 'Ortho': [2365], 'Clinical': [2366], 'Diagnostics),': [2367], 'p53': [2369, 2378, 2439, 2549], '(Santa': [2370, 2398, 2415, 2834, 2840], 'Cruz': [2371, 2399, 2835, 2841], 'Biotechnology,': [2372, 2403], 'Santa': [2374], 'Cruz,': [2375], 'CA),': [2376], '(PAB': [2379, 2443, 2448], '122,': [2380, 2455], 'can': [2382, 2436, 2457, 3082], 'recognize': [2383, 2437, 2458, 3083], 'mutant': [2385, 2446], 'wild': [2387], 'type': [2388], 'p53;': [2389], 'Pharmingen),': [2390], '(Calbiochem),': [2393], 'Biotechnology),': [2400, 2836], 'pRB': [2401], '(Upstate': [2402], 'Lake': [2405], 'Placid,': [2406], 'NY),': [2407], 'polyclonal': [2409, 2810, 2831, 3066, 3076], 'Cruz).': [2416], 'experiments,': [2419, 4124, 4398], 'anti-p53': [2433], 'antibody': [2434, 2475, 2808, 2812, 2833, 2839, 3072, 3081], 'native': [2442], '246)': [2444], '240)': [2449], 'followed': [2450, 2740, 2932, 3153], 'immunoblotting': [2452], 'PAB': [2454], 'forms.': [2460], 'Horseradish': [2461], 'peroxidase-labeled': [2462], 'anti-mouse': [2463], 'anti-rabbit': [2465], 'Ig': [2466], 'detection': [2471], 'bound': [2473, 2850, 3026, 3089], 'enhanced': [2477], 'chemiluminescence': [2478], '(Amersham': [2479, 2894, 2973], 'Pharmacia': [2480, 2895, 2974], 'Biotech).': [2481], 'Total': [2482, 3032], '80%': [2489], 'confluency': [2490, 3159], 'Trizol': [2492], 'reagent': [2493], 'Technologies).': [2495], '(25': [2497], 'μg': [2498, 2799, 2993, 3036], 'each)': [2499], 'agarose,': [2505], '6%': [2506], 'formaldehyde': [2507], 'transferred': [2510], 'membrane.': [2513], 'After': [2514, 2789, 2982], 'baking': [2515], '80': [2519], 'h,': [2523], 'prehybridized': [2527], 'hybridized': [2530], '32P-labeled': [2533], 'probe': [2534], 'Quick-Hyb': [2537], 'hybridization': [2538], 'solution': [2539], '(Stratagene).': [2540], 'Full-length': [2541], 'cDNA': [2544], '(1.3': [2545], 'kilobase': [2546], 'pairs),': [2547], 'cDNA,': [2550], 'p21Waf1/Cip1cDNA,': [2552], '0.8-kilobase': [2555], 'pair': [2556], 'DNA': [2557, 3212], 'fragment': [2558], 'obtained': [2559, 2827], 'digestion': [2561], 'SphI': [2566], 'NcoI': [2568], 'probes.': [2573], 'analysis,': [2577, 3179], '1.0': [2578], '×': [2579, 4132], '104': [2580, 4133], 'seeded': [2583, 2641, 4297], '35-mm': [2586], 'dish': [2589, 2647], 'day': [2591], '0.': [2592], '0.1n': [2597], 'NaOH': [2598], 'measurement': [2601], 'absorbance': [2603], '(A260)': [2604], '(41Kao': [2605], 'C.Y.': [2606], 'Oakley': [2607], 'C.S.': [2608], 'Welsch': [2609], 'C.C.': [2612], 'Vitro': [2614], 'Dev.': [2616], 'Anim...': [2618], '33:': [2620], '282-288Google': [2621], 'trypsinized': [2624, 3161], 'count.': [2628], 'same': [2630, 3394, 3447, 4292], '(100': [2634], 'different': [2637, 3973, 4006, 4190], 'determination': [2649], 'colony': [2651, 3551, 3581, 3635, 3828, 4281, 4324], 'formation': [2652, 3552, 3582, 3829, 4282, 4325], 'efficiency': [2653, 3553, 3583, 3830, 4283, 4326], '10–14': [2658], 'days': [2659, 3512], 'until': [2660, 2921], 'colonies': [2661, 3621, 4303], 'visualized.': [2664], 'Colonies': [2665], 'stained': [2667], '0.25%': [2669], 'Coomassie': [2670], 'Brilliant': [2671], 'Blue': [2672], '(R-250)': [2673], '50%': [2675, 2968], 'methanol': [2676, 3172], 'glacial': [2679], 'acetic': [2680], 'acid': [2681], '(42Frebourg': [2685], 'Kassel': [2687], 'Lam': [2689], 'K.T.': [2690], 'Gryka': [2691], 'M.A.': [2692], 'Barbier': [2693], 'Andersen': [2695], 'T.I.': [2696], 'Borresen': [2697], 'A.L.': [2698], 'Friend': [2699], 'S.H.': [2700], '1992;': [2708, 3250], '89:': [2709, 3251], '6413-6417Google': [2710], 'assay,': [2715], 'employed': [2718], 'transient': [2720], 'recombinant': [2732], 'vaccinia': [2733], 'encoding': [2735], 'T7': [2736], 'polymerase,': [2738], 'vTF7–3,': [2739], 'transfection': [2742], 'pTM1-NS5A-FLAG': [2745], '(FLAG': [2748], 'epitope': [2749], 'tag': [2750], 'located': [2751], 'C-terminal': [2754], 'end': [2755], 'NS5A).': [2757], 'vTF7–3': [2765], 'negative': [2770], 'lysates': [2778, 2791, 3034], 'buffers': [2785], '24': [2786], 'postinfection.': [2788], 'precleaning': [2790], 'normal': [2793], 'rabbit': [2796, 3065, 3075], 'serum,': [2797], '200': [2798, 2874, 2992], 'incubated': [2803, 2962, 3003, 3121], 'anti-': [2806], 'FLAG': [2807], '(IBI),': [2809], 'anti-PSTAIRE': [2811], '(raised': [2813], 'highly': [2816], 'conserved': [2817], 'peptide': [2818], 'motif': [2819], 'present': [2820], 'date;': [2826], 'Oncogene': [2829], 'Science),': [2830], 'anti-Cdk1': [2832, 3067], 'anti-p21Waf1/Cip1': [2838], 'Biotechnology)': [2842], '4': [2847, 2938, 2977, 3009, 4024, 4065], '°C.': [2848], 'Immunocomplexes': [2849, 3088], 'A-agarose': [2853, 3092], 'washed': [2855, 3016, 3182], 'four': [2856, 2986, 3017], 'times': [2857, 2987, 3018], 'IP': [2860], 'washing': [2861, 2983], '7.4,': [2867], 'EDTA,': [2870], '0.5%': [2871], 'P-40,': [2873], 'fluoride)': [2880], 'immunoblotting.': [2886], 'Escherichia': [2887], 'coliXL1-Blue': [2888], 'transformed': [2890], 'pGEX-3X': [2893], 'Biotech)': [2896, 2975], 'pGST-NS5A': [2898], '(43Ide': [2900], 'density': [2924], 'reached': [2925], 'mid-log': [2927], '(A600': [2929], '=': [2930], '0.6),': [2931], 'mmisopropyl-1-thio-β-d-galactopyranoside': [2935], 'h.': [2939, 2981], 'Bacterial': [2940], 'pellets': [2941], 'resuspended': [2943, 3184], 'cold': [2945, 2989, 3020, 3171], 'phosphate-buffered': [2946, 2990, 3021, 3174, 3186], 'saline': [2947, 3022, 3187], 'fluoride': [2952], 'mild': [2956], 'sonication.': [2957], 'soluble': [2959], 'fraction': [2960], '60': [2964], 'μl': [2965, 3098], 'slurry': [2969], 'glutathione-Sepharose': [2971], 'beads': [2972, 2985, 3014], 'saline,': [2991], 'immobilized': [3006], 'GST-NS5A': [3007], 'overnight.': [3011], 'Finally,': [3012, 4040], 'Sepharose': [3013], 'remove': [3024], 'nonspecifically': [3027], 'before': [3028], 'loading': [3029, 3139], 'sample)': [3041], 'neor': [3045], 'CL2-4': [3050, 3379, 3435], 'absence': [3058, 3490, 3505, 3574, 3611, 3758], 'immunoprecipitated': [3062], 'anti-Cdk2': [3071], 'anti-PSTAIR': [3077, 3080], 'antibody.': [3078], 'Cdk2.': [3087], 'suspended': [3094], 'reaction': [3099, 3129], '10': [3107, 3110, 3963], 'μCi': [3111], '[γ-32P]ATP,': [3113], 'histone': [3118], 'H1': [3119], '30': [3123, 3126], 'min.': [3127], 'terminated': [3131], 'addition': [3134, 3337], '6×': [3136], 'sample': [3138], 'buffer.': [3140], 'products': [3143], 'membrane,': [3152], 'autoradiography.': [3155], '50–80%': [3158, 4403], '48': [3162], 'seeding': [3165], 'fixed': [3168], '67%': [3170], 'saline.': [3175], 'Before': [3176], 'cytometric': [3178, 4275, 4394], '20': [3189], 'RNase': [3192], 'propidium': [3197], 'iodide.': [3198], 'performed': [3203], 'Becton-Dickinson': [3206], 'FACSort': [3207], 'cytometer': [3208], 'CellQuest': [3210], 'software.': [3211, 3221], 'distributions': [3213], 'ModFit': [3217], 'LT': [3218], 'version': [3219], '2.0': [3220], 'elucidate': [3223], 'growth,': [3232, 3414, 3440], '(44Gossen': [3239], 'Bujard': [3241], '5547-5551Google': [3252], 'express': [3255], 'Individual': [3261], 'varied': [3278], 'clones.': [3281, 4223], 'One': [3282], '(CL2-4)': [3284, 3421], 'detectable': [3287, 3308, 3358, 3520], 'manner': [3295], 'chosen': [3297, 4435], 'further': [3299, 4059], 'appearance': [3302], '8': [3309], 'medium,': [3317], 'increased': [3323, 4178, 4370, 4507], 'time-dependent': [3326], 'fashion': [3327], '(Fig.1': [3328], 'A)': [3329, 4025], 'concentration': [3342], '63': [3344], 'dramatically': [3349], 'repressed': [3350], 'barely': [3357], 'level': [3359, 3395, 4013], '(Fig.': [3360, 3402, 3462, 3778, 4023, 4037, 4252, 4311], 'B).': [3362, 4313], 'tTA': [3366, 3386], 'empty': [3389, 3474, 3560, 3738], 'confirmed': [3397, 3773, 4071], 'C).': [3404], 'G418-resistant,': [3418], 'clonally': [3419], 'selected': [3420, 4057], 'early': [3424, 3885, 3920], 'passage': [3425, 3886], '(5–10': [3427], 'passages).': [3428], 'markedly': [3437], 'shut': [3460], 'off': [3461], '2,': [3463], 'left).': [3464, 3781], 'On': [3465], 'hand,': [3468], 'no': [3480, 3748, 3858, 4548], 'difference': [3482, 3750, 4550, 4569], '(Fig.2,': [3497], 'right).': [3498], 'declined': [3508], 'gradually': [3509], '7': [3511, 4241], 'up': [3513], 'month': [3516], 'blots,': [3523], 'but': [3524, 3893, 4083, 4334], 'continued': [3531], 'during': [3532], 'period': [3534], '(data': [3544, 3614], 'not': [3545, 3615, 3627, 3895, 4084, 4264, 4358], 'shown).': [3546, 3616], 'We': [3547, 3695, 4111, 4277], 'examined': [3549, 4269], 'NIH3T3-CL2-4': [3566, 3588], 'tetracycline.': [3576, 3760], 'indicate': [3579, 4233, 4419], 'greatly': [3585, 4328], 'when': [3590, 4164, 4268], 'tetracycline,': [3601], 'Although': [3617], 'significantly': [3628], 'affected': [3629], 'Tet-off': [3632, 3770, 4441], 'conditions,': [3633], 'size': [3636], 'reduced,': [3638], 'probably': [3639, 4476], 'due': [3640, 3896, 4212, 4265, 4477], 'tTA-VP16': [3645, 3657, 3898, 4447, 4485], 'activator': [3646], 'earlier': [3653], 'report': [3654], 'confers': [3659], 'morphological': [3660], 'changes': [3661], 'hamster': [3663], 'glioblastoma': [3664], '(45Gallia': [3666], 'Khalili': [3668], 'Oncogene..': [3670], '16:': [3672], '1879-1884Google': [3673], 'growth-inhibitory': [3686, 3725, 3881], 'extend': [3698], 'observation': [3700], 'fibroblasts': [3704], 'RLE.': [3712], 'Expression': [3713], 'RLE': [3720], 'line': [3722, 4138], 'conferred': [3724], 'properties': [3726], '(RLE13': [3727], 'Fig.3': [3729, 3743], 'A,': [3730, 3744], 'left),': [3731], 'whereas': [3732, 4342], '(RLEC2': [3740], 'right)': [3745], 'RLE13': [3766], '3': [3779], 'B,': [3780, 4066, 4232], 'regard,': [3784, 4577], 'interest': [3788], 'note': [3790], 'previous': [3793], 'reported': [3801], 'osteosarcoma': [3819], 'inhibitory': [3823], '(46Moradpour': [3831], 'Englert': [3833], 'Wakita': [3835], 'Wands': [3837], '222:': [3841], '51-63Google': [3842], '47Moradpour': [3844], 'Kary': [3846], 'Blum': [3850], 'H.E.': [3851], '28:': [3854], '192-201Google': [3855], 'data': [3859, 4529], 'presented': [3861], 'evaluate': [3863], 'responsible': [3870], 'study.': [3876], 'ensure': [3878], 'constructed': [3901], 'TheNS5A': [3910], 'cytomegalovirus': [3918], 'immediate': [3919], 'promoter': [3921], 'vector.': [3925], 'NIH3T3,': [3927, 4287], 'plasmid.': [3945, 4089], 'Stable': [3946], 'theneo': [3953], 'r': [3954], 'isolated.': [3960, 4010], 'More': [3961], 'clonal': [3964], 'types.': [3975], 'analyses,': [3991], 'respectively,': [3992], 'types': [4008], 'low': [4018], 'relatively': [4029], 'high': [4030], 'achieved': [4032], 'A).': [4039, 4208, 4254], 'one': [4047], 'analyses.': [4060], 'As': [4061], 'Fig.': [4064, 4228, 4318], 'stably': [4076], 'steady': [4091], 'state': [4092], 'comparable': [4098], 'corresponding': [4101, 4535], 'rates': [4116], 'triplicate': [4125], 'pairs': [4126], 'versusNS5A-expressing': [4129], '(1': [4131], 'cells/plate)': [4134], 'analyzed.': [4140], 'Fig.5': [4145], 'Chang,': [4155, 4286], 'slower': [4163], 'their': [4167, 4353, 4534, 4571], 'counterparts.': [4172], '33.9': [4180], 'average': [4184], '55': [4186], 'lines,': [4195], '18.5': [4198], '26': [4200], '(Fig.5': [4207], '4,': [4229], 'being': [4238], 'days,': [4242], 'longest': [4244], 'point': [4246], 'taken': [4247], 'experiments': [4251], 'apoptosis': [4267], 'visually': [4271], 'dishes,': [4300], 'visualized': [4305], '"Experimental': [4309, 4415], 'Procedures"': [4310], 'lesser': [4337], 'extent': [4338], 'essentially': [4345], 'unchanged': [4346], 'respective': [4354, 4572], 'Since': [4361], 'evidence': [4363], 'thus': [4364], 'far': [4365], 'inhibiting': [4376], 'proliferation,': [4378], 'determine': [4382], 'distribution': [4391, 4410, 4429, 4474, 4528, 4555], 'confluence': [4404], 'Procedures."': [4416], 'depends': [4430], '(TableI).': [4436], 'example,': [4438], '(CL2-4),': [4448], 'predominant': [4450], 'accumulation': [4451], 'G0/G1': [4455], 'decreased': [4459], 'observed': [4463], 'pattern': [4470], 'control.': [4492], 'consistently': [4506], 'proportion': [4508], '(Table': [4522, 4561], 'I,': [4523, 4562], 'bottom).': [4524], 'agreement': [4532], 'attenuated': [4536], 'rates.': [4538, 4574], 'apparent': [4549], 'versuscontrol': [4559], 'bottom),': [4563], 'although': [4564], 'they': [4565], 'show': [4566], 'clear': [4568], 'resembles': [4585], 'immunodeficiency': [4590], 'Vp': [4592]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994750040', 'counts_by_year': [{'year': 2023, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-14T05:41:38.351300', 'created_date': '2016-06-24'}
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