Paradoxical Impact of Antioxidants on Post-Amadori Glycoxidation

Name: Work Video:
Duration: 3 min 30 s
Sean M. Culbertson; Ekaterina Vassilenko; Lisa D. Morrison; K. U. Ingold
{'id': 'https://openalex.org/W1994636910', 'doi': 'https://doi.org/10.1074/jbc.m305099200', 'title': 'Paradoxical Impact of Antioxidants on Post-Amadori Glycoxidation', 'display_name': 'Paradoxical Impact of Antioxidants on Post-Amadori Glycoxidation', 'publication_year': 2003, 'publication_date': '2003-09-26', 'ids': {'openalex': 'https://openalex.org/W1994636910', 'doi': 'https://doi.org/10.1074/jbc.m305099200', 'mag': '1994636910', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12878609'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305099200', 'pdf_url': 'http://www.jbc.org/article/S0021925820831421/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820831421/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062871030', 'display_name': 'Sean M. Culbertson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210135718', 'display_name': 'Steacie Institute for Molecular Sciences', 'ror': 'https://ror.org/02tjxem41', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210135718', 'https://openalex.org/I4210159778']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sean M. Culbertson', 'raw_affiliation_strings': ['Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada'], 'affiliations': [{'raw_affiliation_string': 'Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada', 'institution_ids': ['https://openalex.org/I4210135718']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029040142', 'display_name': 'Ekaterina Vassilenko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210135718', 'display_name': 'Steacie Institute for Molecular Sciences', 'ror': 'https://ror.org/02tjxem41', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210135718', 'https://openalex.org/I4210159778']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Ekaterina I. Vassilenko', 'raw_affiliation_strings': ['Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada'], 'affiliations': [{'raw_affiliation_string': 'Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada', 'institution_ids': ['https://openalex.org/I4210135718']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042432484', 'display_name': 'Lisa D. Morrison', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210096059', 'display_name': 'Institute for Biological Sciences', 'ror': 'https://ror.org/00t7c0489', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210096059', 'https://openalex.org/I4210159778']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Lisa D. Morrison', 'raw_affiliation_strings': ['Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada.'], 'affiliations': [{'raw_affiliation_string': 'Institute for Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada.', 'institution_ids': ['https://openalex.org/I4210096059']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112823944', 'display_name': 'K. U. Ingold', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210135718', 'display_name': 'Steacie Institute for Molecular Sciences', 'ror': 'https://ror.org/02tjxem41', 'country_code': 'CA', 'type': 'facility', 'lineage': ['https://openalex.org/I4210135718', 'https://openalex.org/I4210159778']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Keith.U. Ingold', 'raw_affiliation_strings': ['Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada'], 'affiliations': [{'raw_affiliation_string': 'Steacie Institute for Molecular Sciences, National Research Council of Canada, Ottawa, Ontario K1A 0R6, Canada', 'institution_ids': ['https://openalex.org/I4210135718']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.685, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 52, 'citation_normalized_percentile': {'value': 0.780022, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '278', 'issue': '40', 'first_page': '38384', 'last_page': '38394'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11142', 'display_name': 'Advanced Glycation End Products research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11140', 'display_name': 'Natural Antidiabetic Agents Studies', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10035', 'display_name': 'Phytochemicals and Antioxidant Activities', 'score': 0.9869, 'subfield': {'id': 'https://openalex.org/subfields/2704', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/amadori-rearrangement', 'display_name': 'Amadori rearrangement', 'score': 0.8011067}], 'concepts': [{'id': 'https://openalex.org/C118094880', 'wikidata': 'https://www.wikidata.org/wiki/Q452196', 'display_name': 'Amadori rearrangement', 'level': 4, 'score': 0.8011067}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5768362}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.50985307}, {'id': 'https://openalex.org/C31903555', 'wikidata': 'https://www.wikidata.org/wiki/Q1637030', 'display_name': 'Food science', 'level': 1, 'score': 0.36561748}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.34225374}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34063298}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2624566}, {'id': 'https://openalex.org/C147990577', 'wikidata': 'https://www.wikidata.org/wiki/Q25790', 'display_name': 'Glycation', 'level': 3, 'score': 0.21950561}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17866477}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305099200', 'pdf_url': 'http://www.jbc.org/article/S0021925820831421/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.openaccessrepository.it/record/94953', 'pdf_url': 'https://www.openaccessrepository.it/record/94953/files/fulltext.pdf', 'source': {'id': 'https://openalex.org/S4306402478', 'display_name': 'INFM-OAR (INFN Catania)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210116497', 'host_organization_name': 'Istituto Nazionale di Fisica Nucleare, Sezione di Catania', 'host_organization_lineage': ['https://openalex.org/I4210116497'], 'host_organization_lineage_names': ['Istituto Nazionale di Fisica Nucleare, Sezione di Catania'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m305099200', 'pdf_url': 'http://www.jbc.org/article/S0021925820831421/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'display_name': 'Clean water and sanitation', 'score': 0.62}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1518714662', 'https://openalex.org/W1524312765', 'https://openalex.org/W1532082751', 'https://openalex.org/W1553609829', 'https://openalex.org/W1554776556', 'https://openalex.org/W1896619220', 'https://openalex.org/W1912804942', 'https://openalex.org/W1936913048', 'https://openalex.org/W1965802284', 'https://openalex.org/W1966116228', 'https://openalex.org/W1968003131', 'https://openalex.org/W1968686222', 'https://openalex.org/W1973095330', 'https://openalex.org/W1974843607', 'https://openalex.org/W1980960629', 'https://openalex.org/W1981718074', 'https://openalex.org/W1982177737', 'https://openalex.org/W1985013075', 'https://openalex.org/W2008219736', 'https://openalex.org/W2008463780', 'https://openalex.org/W2011065483', 'https://openalex.org/W2011747609', 'https://openalex.org/W2013059463', 'https://openalex.org/W2017214714', 'https://openalex.org/W2019167499', 'https://openalex.org/W2019522259', 'https://openalex.org/W2028732326', 'https://openalex.org/W2052494957', 'https://openalex.org/W2057162977', 'https://openalex.org/W2058345849', 'https://openalex.org/W2063284869', 'https://openalex.org/W2064532629', 'https://openalex.org/W2070113401', 'https://openalex.org/W2070207143', 'https://openalex.org/W2070475580', 'https://openalex.org/W2071267404', 'https://openalex.org/W2072692635', 'https://openalex.org/W2074025286', 'https://openalex.org/W2074712105', 'https://openalex.org/W2075049539', 'https://openalex.org/W2082865005', 'https://openalex.org/W2098587915', 'https://openalex.org/W2102131116', 'https://openalex.org/W2105473120', 'https://openalex.org/W2116458615', 'https://openalex.org/W2116971743', 'https://openalex.org/W2130263413', 'https://openalex.org/W2135894632', 'https://openalex.org/W2145124208', 'https://openalex.org/W2145738090', 'https://openalex.org/W2156599039', 'https://openalex.org/W2164023752', 'https://openalex.org/W2168897708', 'https://openalex.org/W2279479268', 'https://openalex.org/W655437407', 'https://openalex.org/W820854987', 'https://openalex.org/W9545647'], 'related_works': ['https://openalex.org/W4249176446', 'https://openalex.org/W2140569197', 'https://openalex.org/W2132898409', 'https://openalex.org/W2064362993', 'https://openalex.org/W2040058909', 'https://openalex.org/W2037631372', 'https://openalex.org/W2030889776', 'https://openalex.org/W1979139803', 'https://openalex.org/W1966775726', 'https://openalex.org/W1966504330'], 'abstract_inverted_index': {'The': [0, 112, 250, 362, 814, 888, 915, 922, 949, 1371, 1502, 1792, 1828, 2109, 2224, 2533, 2698, 3204, 3558, 3651, 3682, 3858, 3967, 3992, 4060, 4132], 'inhibition': [1, 182, 190, 251, 432, 440, 1103, 2331, 2377, 3272, 3280], 'of': [2, 14, 37, 50, 68, 128, 133, 145, 152, 170, 183, 191, 204, 210, 215, 243, 252, 264, 287, 300, 318, 378, 383, 395, 402, 420, 433, 441, 454, 460, 465, 493, 515, 527, 711, 782, 787, 790, 795, 803, 881, 890, 925, 958, 988, 1025, 1034, 1077, 1185, 1197, 1383, 1439, 1448, 1575, 1619, 1632, 1687, 1748, 1830, 1907, 2058, 2066, 2123, 2181, 2204, 2332, 2363, 2375, 2379, 2426, 2472, 2474, 2494, 2505, 2543, 2593, 2603, 2637, 2654, 2724, 2735, 2899, 2923, 2976, 3017, 3052, 3100, 3157, 3192, 3217, 3222, 3228, 3233, 3253, 3273, 3281, 3294, 3300, 3305, 3343, 3357, 3377, 3390, 3408, 3473, 3510, 3565, 3636, 3692, 3731, 3764, 3804, 3837, 3860, 3919, 4000, 4021, 4048, 4095], 'post-Amadori': [3, 253, 1183, 2242, 2270, 2333, 2344, 2753, 3184, 3361], 'advanced': [4, 254, 531, 541, 610], 'glycation': [5, 255, 502, 532, 542, 611, 1123, 1188, 1267, 1351, 1747, 2205, 2233, 2255, 2294, 2358, 3058, 3545, 4019, 4160], 'end': [6, 256, 533, 543, 612], 'product': [7, 257, 973, 1353], '(AGE)': [8, 258], 'formation': [9, 36, 49, 144, 259, 286, 299, 394, 794, 868, 957, 987, 1101, 1184, 1447, 1480, 1553, 1618, 1745, 1906, 2493, 2542, 2602, 2649, 3186, 3227, 3376, 3389], 'by': [10, 260, 503, 1128, 1193, 1214, 1486, 1794, 2200, 2291, 2659, 3014, 3094, 3187, 3340, 3570, 3728, 3761, 3891, 3949, 3997, 4004, 4080, 4166], 'three': [11, 261, 3189, 3909], 'different': [12, 262, 1977, 3190], 'classes': [13, 263, 2180, 3191], 'AGE': [15, 30, 39, 55, 80, 99, 265, 280, 289, 305, 330, 349, 699, 717, 796, 867, 989, 1100, 1204, 1212, 1261, 1388, 1449, 1479, 1552, 1876, 1978, 2059, 2115, 2143, 2243, 2334, 2345, 2348, 2430, 2475, 2496, 2535, 2648, 2705, 2744, 2817, 3151, 3159, 3185, 3193, 3370, 3379, 3395], 'inhibitors,': [16, 175, 266, 425, 2182, 3258], 'carbonyl': [17, 90, 267, 340, 1835, 2137, 2436, 2599, 2639, 2663, 2712, 3146, 3195, 3264], 'group': [18, 268, 2975, 3056, 3147, 3196, 3265], 'traps,': [19, 269, 2640, 3197], 'chelators,': [20, 270, 3200], 'and': [21, 52, 95, 106, 116, 140, 155, 176, 193, 223, 247, 271, 302, 345, 356, 366, 390, 405, 426, 443, 473, 497, 519, 704, 724, 807, 821, 883, 920, 1023, 1029, 1087, 1102, 1202, 1273, 1453, 1509, 1556, 1577, 1624, 1757, 1842, 2139, 2191, 2195, 2269, 2383, 2387, 2479, 2499, 2546, 2581, 2591, 2644, 2717, 2720, 2728, 2902, 2978, 2986, 3062, 3149, 3154, 3168, 3201, 3238, 3259, 3266, 3283, 3347, 3363, 3392, 3418, 3434, 3445, 3500, 3518, 3539, 3607, 3657, 3739, 3759, 3848, 3899, 3933, 4068, 4071, 4140, 4198, 4219], 'radical-trapping': [22, 96, 134, 174, 216, 272, 346, 384, 424, 466, 2192, 2718, 3070, 3150, 3202, 3239, 3257, 3267, 3306, 3358], 'antioxidants,': [23, 157, 273, 407, 3224, 3240], 'challenge': [24, 274, 3364], 'the': [25, 35, 126, 131, 150, 188, 208, 213, 220, 232, 241, 275, 285, 376, 381, 400, 438, 458, 463, 470, 482, 491, 707, 780, 793, 819, 879, 902, 983, 1026, 1078, 1085, 1178, 1345, 1384, 1434, 1440, 1445, 1507, 1573, 1617, 1620, 1630, 1633, 1749, 1800, 1838, 2114, 2121, 2229, 2361, 2373, 2384, 2422, 2427, 2470, 2482, 2492, 2503, 2541, 2635, 2652, 2722, 2732, 2736, 2741, 2805, 2896, 2900, 2972, 2981, 2996, 3000, 3015, 3050, 3053, 3096, 3215, 3220, 3231, 3262, 3278, 3298, 3303, 3312, 3323, 3332, 3341, 3365, 3375, 3430, 3504, 3508, 3511, 3563, 3634, 3690, 3729, 3762, 3833, 3916, 3931, 3998, 4044, 4084, 4093], 'current': [26, 276, 3366], 'paradigms': [27, 277, 3367], 'that:': [28, 278, 3368], '1)': [29, 121, 279, 371, 3210, 3369], 'inhibitors': [31, 56, 100, 281, 306, 350, 1213, 2060, 2116, 2349, 2431, 2476, 3160, 3371, 3396, 3838, 4050], 'will': [32, 282, 3372], 'not': [33, 283, 1458, 2069, 2511, 2994, 3373], 'increase': [34, 124, 284, 374, 2988, 3213, 3374], 'any': [38, 288, 1889, 3378], 'product,': [40, 290, 1376, 3380], '2)': [41, 142, 291, 392, 3225, 3381], 'transition': [42, 61, 292, 311, 1544, 1892, 2364, 3382, 3401, 3474, 3566], 'metal': [43, 62, 92, 206, 221, 224, 244, 293, 312, 342, 456, 471, 474, 494, 1491, 1545, 1893, 2185, 2365, 2440, 2586, 2714, 3164, 3169, 3198, 3235, 3296, 3313, 3324, 3344, 3383, 3402, 3475, 3512, 3567], 'ions': [44, 63, 207, 294, 313, 457, 1492, 1546, 3297, 3384, 3403], 'are': [45, 238, 295, 488, 772, 1268, 1457, 1559, 1614, 2068, 2583, 3338, 3385], 'required': [46, 296, 1560, 1615, 3386], 'for': [47, 297, 818, 872, 1433, 1506, 1616, 1784, 1891, 2598, 2911, 3387, 3497, 3541, 3562, 3604, 3611, 3617, 3753, 3870, 3915, 3958, 4156], 'oxidative': [48, 298, 520, 1487, 1612, 1756, 2202, 3388], 'AGE,': [51, 301, 540, 609, 3391], '3)': [53, 168, 303, 418, 3251, 3393], 'screening': [54, 304, 3394], 'only': [57, 307, 2534, 2826, 2835, 3397, 3619, 3718, 3789, 3846, 3862], 'in': [58, 70, 125, 130, 149, 200, 212, 240, 308, 320, 375, 380, 399, 450, 462, 490, 731, 779, 801, 878, 918, 991, 1094, 1182, 1265, 1391, 1481, 1554, 1684, 1846, 1881, 1984, 2228, 2356, 2360, 2421, 2657, 2731, 3163, 3214, 3219, 3230, 3290, 3302, 3311, 3322, 3398, 3410, 3429, 3625, 3744, 3809, 3832, 3844, 3886, 3961, 4027, 4043, 4142], 'systems': [59, 309, 3399], 'containing': [60, 310, 3400], 'represents': [64, 314, 3404], 'a': [65, 77, 88, 201, 315, 327, 338, 451, 512, 525, 776, 959, 968, 1032, 1195, 1549, 1697, 1781, 2056, 2124, 2235, 2702, 2711, 2811, 2836, 3005, 3018, 3155, 3211, 3291, 3354, 3405, 3437, 3459, 3483, 4174], 'valid': [66, 316, 3406], 'estimate': [67, 317, 3407], 'potential': [69, 319, 2898, 2998, 3409], 'vivo': [71, 321, 992, 1555, 1685, 2658, 3411], 'mechanisms.': [72, 322, 3412], 'This': [73, 323, 977, 1163, 1779, 3144], 'work': [74, 324, 2700], 'also': [75, 110, 325, 360, 1678, 1981, 2894, 3046, 3537, 4055], 'introduces': [76, 326], 'novel': [78, 328, 1832, 2703, 3263, 3652], 'multifunctional': [79, 329, 2704, 3271], 'inhibitor,': [81, 331, 2745, 3152], '6-dimethylaminopyridoxamine': [82, 332, 563, 632], '(dmaPM),': [83, 333], 'designed': [84, 334, 1097, 2707], 'to': [85, 166, 335, 416, 524, 706, 774, 865, 967, 986, 1098, 1160, 1169, 1343, 1380, 1387, 1444, 1561, 1572, 1681, 1694, 1884, 1903, 2118, 2142, 2231, 2240, 2253, 2325, 2371, 2419, 2435, 2439, 2490, 2501, 2538, 2646, 2708, 2751, 2824, 2906, 2971, 2999, 3048, 3066, 3249, 3469, 3507, 3576, 3633, 3662, 3689, 3850, 3878, 4092, 4136, 4231], 'function': [86, 336, 723, 2709], 'as': [87, 138, 337, 388, 507, 894, 901, 1494, 2128, 2184, 2247, 2341, 2642, 2710, 2810, 2927, 2968, 3092, 4002, 4204], 'combined': [89, 339], 'trap,': [91, 341, 2713], 'ion': [93, 245, 343, 495, 1894, 2186, 2441, 2587, 2715, 3199, 3236, 3345, 3513, 3568], 'chelator,': [94, 344, 2716], 'antioxidant.': [97, 347], 'Other': [98, 348, 1872, 2179, 2347], 'including': [101, 351, 2259], 'pyridoxamine,': [102, 352], 'aminoguanidine,': [103, 353], 'o-phenylenediamine,': [104, 354], 'dipyridoxylamine,': [105, 355], 'diethylenetriaminepentaacetic': [107, 357, 570, 639], 'acid': [108, 358, 2189, 3520], 'were': [109, 359, 2250, 2323, 3064, 3161, 3414, 3450, 3550, 3560, 3659, 3842, 3884, 3904, 3922, 3969, 3995, 4036, 4062, 4089, 4134], 'examined.': [111, 361], 'results': [113, 363, 3177, 3205], 'during': [114, 364, 1551, 1746, 1789, 3057, 3206], 'uninterrupted': [115, 365, 2357], 'interrupted': [117, 367, 2293], 'ribose': [118, 368, 1802, 3207, 3736, 3952, 4157], 'glycations': [119, 186, 369, 436, 3208, 3276], 'show:': [120, 370, 3209], 'an': [122, 372, 1683, 2129, 2342, 2908, 2917, 2928], 'unexpected': [123, 373, 1801, 3176], 'yield': [127, 209, 377, 459, 2504, 3216, 3299], 'pentosidine': [129, 192, 379, 442, 1274, 1744, 1790, 1796, 2513, 2547, 3218, 3282, 4233], 'presence': [132, 151, 214, 242, 382, 401, 464, 492, 2122, 2362, 3221, 3232, 3304, 3342, 3564, 3836, 4047], 'phenolic': [135, 156, 385, 406, 2881, 2973, 3223], 'antioxidants': [136, 217, 386, 467, 2193, 3071, 3307, 3359], 'such': [137, 387, 506, 893, 1493, 2127, 2183, 2246, 2641, 2892, 2907], 'Trolox': [139, 389, 592, 661], 'dmaPM,': [141, 391, 562, 631, 3153, 3269], 'significant': [143, 393, 777, 3226], 'N': [146, 396, 557, 626, 1269, 1804, 3732, 3740], 'ϵ-carboxymethyllysine': [147, 397], '(CML)': [148, 398, 1272], 'strong': [153, 403, 2638, 2964, 3234], 'chelators': [154, 246, 404, 496, 2187, 2588, 3237, 3346, 3514], 'which': [158, 408, 1173, 1570, 1795, 2133, 2367, 2886, 3241, 3490], 'implies': [159, 409, 3242], 'that': [160, 178, 234, 410, 428, 484, 522, 863, 964, 1156, 1456, 1543, 1557, 1689, 1875, 2327, 2740, 2804, 2963, 3002, 3178, 3243, 3261, 3334], 'there': [161, 411, 3003, 3244], 'must': [162, 412, 3245], 'be': [163, 413, 1161, 1170, 1344, 1381, 1682, 1692, 1982, 2239, 2748, 2916, 3067, 3246], 'nonradical': [164, 414, 3247], 'routes': [165, 415, 3248], 'CML,': [167, 417, 556, 625, 3250], 'prevention': [169, 419, 3252], 'intermolecular': [171, 421, 1786, 3254], 'cross-links': [172, 422, 2514, 3255], 'with': [173, 195, 423, 445, 896, 955, 2262, 2354, 2934, 3008, 3256, 3285, 3436, 3466, 3493, 3527, 3717, 3788, 3820, 3951], '4)': [177, 427, 3260], 'dmaPM': [179, 429, 3061, 3656], 'shows': [180, 430, 2596, 3270], 'excellent': [181, 431], 'AGE.': [184, 434, 3274], 'Glucose': [185, 435, 3275], 'reveal': [187, 437, 3277], 'expected': [189, 439, 1693, 2252, 3279], 'CML': [194, 211, 444, 461, 1340, 1636, 2545, 3229, 3284, 3301], 'all': [196, 446, 3286, 3871], 'compounds': [197, 447, 528, 2138, 2595, 3287], 'tested,': [198, 448, 3288], 'but': [199, 449, 1220, 2992, 3289], 'buffer': [202, 452, 3292, 3455, 3479, 3524, 3606, 3620, 3748, 3811, 3814, 3847, 3853, 3856, 3863, 3979, 3982, 3987, 4029, 4034, 4146], 'free': [203, 453, 1886, 3293, 3803], 'trace': [205, 455, 3295, 3471], 'was': [218, 468, 1752, 2339, 3012, 3045, 3308, 3318, 3432, 3458, 3482, 3491, 3536, 3599, 3621, 3630, 3686, 3726, 3807, 3867, 3876, 3945, 4164, 4229], 'between': [219, 469, 1975], 'ion-free': [222, 472, 3170, 3314, 3478], 'ion-containing': [225, 475, 3165, 3325, 3454], 'controls.': [226, 476], 'Protein': [227, 477, 3327], 'molecular': [228, 478, 573, 642, 3328], 'weight': [229, 479, 3329, 3972], 'analyses': [230, 480, 3330], 'support': [231, 481, 3331], 'conclusion': [233, 483, 3333], 'Amadori': [235, 485, 972, 978, 1027, 1442, 1848, 2267, 3335], 'decomposition': [236, 486, 3336], 'pathways': [237, 487, 733, 1018, 2389, 2734, 3337], 'constrained': [239, 489], 'radical': [248, 498, 2729, 2816, 2888, 2920, 2989, 3348], 'traps.': [249, 499, 3349], 'Nonenzymatic': [500], 'protein': [501, 722, 875, 1190, 1266, 3993], 'reducing': [504, 897, 1079, 2263], 'sugars,': [505, 2264], 'glucose': [508, 4159], 'or': [509, 726, 951, 1081, 1496, 1700, 2131, 2438, 2606, 3074, 3533, 3544, 3812, 3828, 3835, 3854, 3908, 3980, 4032, 4046, 4153, 4158], 'ribose,': [510], 'is': [511, 899, 1341, 1378, 1483, 1540, 1797, 2120, 2417, 2477, 2922, 3004], 'complicated': [513], 'cascade': [514], 'condensations,': [516], 'rearrangements,': [517], 'fragmentations,': [518], 'modifications': [521, 3720, 3791], 'lead': [523], 'plethora': [526], 'collectively': [529], 'called': [530], 'products': [534, 700, 718, 990, 1262, 2144, 2497], '(AGEs)': [535], '1The': [536], 'abbreviations': [537, 606], 'used': [538, 607, 3419, 3428, 3540, 4230], 'are:': [539, 608], 'product;': [544, 613], 'ABAP,': [545, 614], '2,2′-azobis(2-amidinopropane)': [546, 615], 'dihydrochloride;': [547, 564, 579, 616, 633, 648], 'Ac-Pt,': [548, 617], 'di-N-acetylpentosidine;': [549, 618], 'AG,': [550, 619], 'aminoguanidine;': [551, 620], 'BSA,': [552, 621], 'bovine': [553, 622], 'serum': [554, 623, 3797], 'albumin;': [555, 624], 'ϵ-carboxymethyllysine;': [558, 627], 'diPM,': [559, 628], 'dipyridoxylamine': [560, 629], 'trihydrochloride;': [561, 630], 'dmaPN,': [565, 634], '6-dimethylaminopyridoxine': [566, 635], 'hydrochloride': [567, 582, 636, 651], '(6-dimethylaminopyridoxol-HCl);': [568, 637], 'DTPA,': [569, 638], 'acid;': [571, 640], 'MW,': [572, 641], 'weight;': [574, 643], 'o-PD,': [575, 644], 'ortho-phenylenediamine;': [576, 645], 'PM,': [577, 646, 2746], 'pyridoxamine': [578, 647, 2337], 'PN,': [580, 649], 'pyridoxine': [581, 650, 3040], '(pyridoxol);': [583, 652], 'RI,': [584, 653], 'refractive': [585, 654], 'index;': [586, 655], 'SEC,': [587, 656], 'size': [588, 657], 'exclusion': [589, 658], 'chromatography;': [590, 599, 659, 668], 'Tx,': [591, 660], '(6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic': [593, 662], 'acid);': [594, 663], 'HPLC,': [595, 664], 'high': [596, 665, 2380], 'pressure': [597, 666], 'liquid': [598, 667], 'MALDI-TOF,': [600, 669], 'matrix-assisted': [601, 670], 'laser': [602, 671], 'desorption': [603, 672], 'ionization': [604, 673, 2897, 2997], 'time-of-flight.1The': [605], 'time-of-flight.': [674], '(1Booth': [675, 993, 1132, 2299], 'A.A.': [676, 994, 1133, 2300], 'Khalifah': [677, 995, 1134, 2301], 'R.G.': [678, 932, 996, 1041, 1105, 1135, 1462, 2207, 2273, 2302, 2516], 'Todd': [679, 997, 1136, 2303], 'P.': [680, 998, 1137, 1311, 1417, 2077, 2304, 2782], 'Hudson': [681, 935, 999, 1044, 1108, 1138, 1465, 2210, 2276, 2305, 2519, 2761], 'B.G.': [682, 936, 1000, 1045, 1109, 1139, 1466, 2211, 2277, 2306, 2520, 2762], 'J.': [683, 914, 1001, 1067, 1140, 1247, 1296, 1404, 1419, 1581, 1644, 1660, 1707, 1724, 1727, 1767, 1813, 1856, 1999, 2039, 2170, 2307, 2398, 2451, 2570, 2618, 2686, 2763, 2848, 2949, 3113, 3580, 3708, 3776, 4120], 'Biol.': [684, 836, 852, 1002, 1141, 1405, 1529, 1600, 1647, 1661, 1708, 1728, 1770, 1857, 2002, 2040, 2151, 2308, 2399, 2452, 2619, 2764, 2849, 3777], 'Chem.': [685, 1003, 1142, 1406, 1662, 1709, 1729, 1817, 1858, 1919, 1945, 1963, 2020, 2041, 2309, 2400, 2453, 2620, 2765, 2850, 2951, 3116, 3778], '1997;': [686, 1004, 1143, 2310, 3709], '272:': [687, 1005, 1144, 2311], '5430-5437Abstract': [688, 1006, 1145, 2312], 'Full': [689, 691, 1007, 1009, 1146, 1148, 1329, 1331, 1410, 1666, 1668, 1713, 1733, 1735, 1862, 1864, 2045, 2047, 2313, 2315, 2404, 2406, 2457, 2459, 2624, 2626, 2769, 2771, 2854, 2856, 3782], 'Text': [690, 692, 1008, 1010, 1147, 1149, 1330, 1332, 1411, 1667, 1669, 1714, 1734, 1736, 1863, 1865, 2046, 2048, 2314, 2316, 2405, 2407, 2458, 2460, 2625, 2627, 2770, 2772, 2855, 2857, 3783], 'PDF': [693, 1011, 1150, 1333, 1412, 1670, 1715, 1737, 1866, 2049, 2317, 2408, 2461, 2628, 2773, 2858, 3784], 'PubMed': [694, 747, 765, 841, 857, 944, 1012, 1053, 1117, 1151, 1254, 1303, 1334, 1366, 1413, 1428, 1474, 1534, 1587, 1605, 1651, 1671, 1716, 1738, 1774, 1823, 1867, 1925, 1949, 1967, 2006, 2024, 2050, 2088, 2104, 2156, 2219, 2285, 2318, 2409, 2462, 2528, 2629, 2693, 2774, 2797, 2859, 2873, 2956, 3034, 3087, 3120, 3139, 3587, 3646, 3677, 3712, 3785, 4013, 4127], 'Scopus': [695, 748, 766, 842, 858, 945, 1013, 1054, 1118, 1152, 1255, 1304, 1335, 1367, 1475, 1535, 1588, 1606, 1652, 1672, 1739, 1775, 1824, 1868, 1926, 1950, 1968, 2007, 2025, 2051, 2089, 2105, 2157, 2220, 2286, 2319, 2410, 2463, 2529, 2630, 2694, 2775, 2798, 2860, 2874, 2957, 3035, 3088, 3121, 3140, 3588, 3647, 3678, 3713, 4014, 4128], '(257)': [696, 1014, 1153, 2320], 'Google': [697, 750, 768, 844, 860, 947, 1015, 1056, 1074, 1120, 1154, 1257, 1306, 1337, 1369, 1414, 1429, 1477, 1537, 1590, 1608, 1654, 1674, 1717, 1741, 1777, 1826, 1870, 1928, 1952, 1970, 2009, 2027, 2053, 2091, 2107, 2159, 2177, 2222, 2288, 2321, 2412, 2465, 2531, 2577, 2632, 2696, 2777, 2800, 2862, 2876, 2959, 3037, 3090, 3123, 3142, 3590, 3649, 3680, 3715, 3786, 4016, 4130], 'Scholar).': [698, 769, 861, 948, 1016, 1075, 1121, 1258, 1338, 1370, 1430, 1478, 1538, 1609, 1675, 1742, 1778, 1827, 1871, 2054, 2108, 2178, 2223, 2289, 2413, 2532, 2578, 2633, 2697, 2877, 3038, 3143, 3591, 3650, 3681, 4017, 4131], 'slowly': [701], 'build': [702], 'up': [703, 2651], 'contribute': [705], 'age-dependent': [708], 'chemical': [709], 'modification': [710, 876], 'long-lived': [712], 'tissue': [713], 'proteins.': [714], 'Once': [715], 'formed,': [716], 'may': [719, 869, 1174, 1547, 1878, 1980, 2747], 'prevent': [720, 2140, 3879], 'normal': [721], 'recognition': [725], 'stimulate': [727], 'potentially': [728], 'detrimental': [729], 'interactions': [730], 'signaling': [732], '(2Bierhaus': [734], 'A.': [735, 1319, 2096, 2562, 2784], 'Hofmann': [736], 'M.A.': [737, 1321, 1657], 'Ziegler': [738], 'R.': [739, 813, 1238, 1287, 1501, 2560, 2677, 4111], 'Nawroth': [740], 'P.P.': [741], 'Cardiovasc.': [742], 'Res.': [743, 761, 939, 1048, 1112, 1469, 1920, 2083, 2214, 2280, 2523], '1998;': [744], '37:': [745], '586-600Crossref': [746], '(509)': [749], 'Scholar,': [751, 831, 845, 930, 1057, 1307, 1415, 1519, 1591, 1655, 1718, 1953, 2010, 2028, 2092, 2160, 2778, 2863, 3124], '3Schmidt': [752], 'A.M.': [753], 'Yan': [754], 'S.D.': [755], 'Wautier': [756], 'J.-L.': [757], 'Stern': [758], 'D.': [759, 2081], 'Circ.': [760], '1999;': [762, 941, 1050, 1114, 1471, 1648, 1771, 1922, 2003, 2085, 2216, 2282, 2525, 3136], '84:': [763], '489-497Crossref': [764], '(698)': [767], 'Glycation': [770], 'reactions': [771, 1455, 1788], 'believed': [773, 1342, 1379], 'have': [775, 1125, 1223, 1900, 1933, 2061, 2350, 2825, 2961], 'role': [778, 1550, 1783], 'progression': [781, 2141], 'diabetic': [783, 804], 'complications': [784], 'largely': [785], 'because': [786, 2378, 2930], 'elevated': [788], 'levels': [789, 2382, 3472], 'glucose.': [791], 'Indeed,': [792], 'has': [797, 980, 1208, 1677, 1806, 2487, 2548, 2821], 'been': [798, 981, 1126, 1224, 1679, 1808, 1901, 1934, 2062, 2352, 2488, 2549, 2822], 'increasingly': [799], 'implicated': [800], 'pathogenesis': [802], 'complications,': [805], 'atherosclerosis,': [806], "Alzheimer's": [808], 'disease': [809], '(4Baynes': [810, 1498], 'J.W.': [811, 847, 912, 934, 1043, 1107, 1361, 1403, 1464, 1499, 1642, 1765, 1943, 1961, 1997, 2018, 2146, 2209, 2275, 2397, 2450, 2518, 2617, 2760, 2847, 3706, 3775], 'Ikan': [812, 1500], 'Maillard': [815, 903, 916, 1436, 1503, 1985, 2737], 'Reaction:': [816, 1504], 'Consequences': [817, 1505], 'Chemical': [820, 1508], 'Life': [822, 1510], 'Sciences.': [823, 1511], 'John': [824, 1512], 'Wiley': [825, 1513], '&': [826, 1514], 'Sons,': [827, 1515], 'Chichester,': [828, 1516], 'UK1996:': [829, 1517], '55-72Google': [830, 1518], '5Uchida': [832], 'K.': [833, 1061, 1236, 1246, 1285, 1295, 2164, 2556, 2569, 2675, 2685, 3108, 4109, 4119], 'Free': [834, 850, 1527, 1598, 2149], 'Radical': [835, 851, 1528, 1599, 2150], 'Med.': [837, 853, 1530, 1601, 2082, 2152], '2000;': [838, 854, 1071, 1326, 1531, 2101, 2153, 2174, 2574, 2851], '28:': [839, 855, 1364, 2154], '1685-1696Crossref': [840], '(532)': [843], '6Baynes': [846], 'Thorpe': [848, 909, 1358, 1400, 1639, 1762, 1940, 1958, 1994, 2015, 2147, 2394, 2447, 2614, 2844, 3703, 3772], 'S.R.': [849, 910, 1359, 1401, 1640, 1763, 1941, 1959, 1995, 2016, 2148, 2395, 2448, 2615, 2845, 3704, 3773], '1708-1716Crossref': [856, 2155], '(468)': [859, 2158], 'Inhibitors': [862, 2245], 'act': [864], 'reduce': [866, 2540], 'prove': [870], 'useful': [871], 'limiting': [873, 2201], 'nonenzymatic': [874], 'associated': [877], 'pathology': [880], 'these': [882, 1216, 1221, 2594], 'other': [884, 3158], 'chronic': [885], 'agerelated': [886], 'diseases.': [887], 'reaction': [889, 904, 1437, 1986, 2261, 3007, 3548, 3730], 'amino': [891], 'compounds,': [892, 1037], 'lysine,': [895], 'sugars': [898], 'known': [900, 2117, 2742], '(7Degenhardt': [905], 'T.P.': [906, 3702], 'Brinkmann-Frye': [907], 'E.': [908, 3700], 'Baynes': [911, 933, 1042, 1106, 1360, 1402, 1463, 1641, 1764, 1942, 1960, 1996, 2017, 2208, 2274, 2396, 2449, 2517, 2616, 2759, 2846, 3705, 3774], "O'Brein": [913], 'Reaction': [917], 'Foods': [919], 'Medicine.': [921], 'Royal': [923], 'Society': [924], 'Chemistry,': [926], 'Cambridge,': [927], 'UK1998:': [928], '3-10Google': [929], '8Khalifah': [931], 'Biochem.': [937, 1046, 1110, 1467, 1645, 1768, 2000, 2099, 2212, 2278, 2521, 2792, 2869, 3581, 3641, 3707, 4009], 'Biophys.': [938, 1047, 1111, 1468, 2213, 2279, 2522, 2793, 3582, 3642], 'Commun.': [940, 1049, 1113, 1470, 2215, 2281, 2524], '257:': [942, 1051, 1115, 1472, 2217, 2283, 2526], '251-258Crossref': [943, 1052, 1116, 1473, 2218, 2284, 2527], '(251)': [946, 1055, 1119, 1476, 2221, 2287, 2530], '“classical”': [950], 'Hodge': [952], 'pathway': [953, 979, 2230], 'begins': [954], 'reversible': [956], 'Schiff': [960], 'base': [961, 1083], 'aldimine': [962], 'adduct': [963, 1635], 'undergoes': [965], 'rearrangement': [966, 1022], 'relatively': [969], 'irreversible': [970, 1446], 'ketoamine': [971], '(see': [974, 3721, 3792, 3912], 'supplemental': [975, 3722, 3793], 'material).': [976, 3723, 3794], 'considered': [982, 1680], 'primary': [984], 'route': [985], 'Post-Amadori': [1017], 'proceed': [1019], 'through': [1020], 'direct': [1021, 2260, 3006], 'fragmentation': [1024], 'compound': [1028], 'probably': [1030], 'form': [1031, 1885], 'variety': [1033, 1196, 2057], 'reactive': [1035, 2136, 2265, 2726], 'dicarbonyl': [1036, 1621], 'especially': [1038, 1988], 'α-ketoaldehydes': [1039], '(8Khalifah': [1040, 1104, 1461, 2206, 2272, 2515], '9Miyata': [1058, 2161], 'T.': [1059, 1227, 1276, 2162, 2552, 2666, 3104, 3106, 4100], 'Kurokawa': [1060, 1245, 1294, 2163, 2568, 2684, 4118], 'Van': [1062, 1228, 1277, 2165, 2563, 2667, 4101], 'Ypersele': [1063, 1229, 1278, 2166, 2564, 2668, 4102], 'De': [1064, 1230, 1279, 2167, 2565, 2669, 4103], 'Strihou': [1065, 1231, 1280, 2168, 2566, 2670, 4104], 'C.': [1066, 1232, 1281, 2169, 2567, 2671, 3126, 4105], 'Am.': [1068, 1248, 1297, 2171, 2571, 2687, 2950, 4121], 'Soc.': [1069, 1249, 1298, 2172, 2572, 2688, 2952, 4122], 'Nephrol.': [1070, 1250, 1299, 2173, 2573, 2689, 4123], '11:': [1072, 2175, 2575], '1744-1752PubMed': [1073, 2176], 'Autoxidation': [1076], 'sugar': [1080, 2381, 3932], "Schiff's": [1082], 'adduct,': [1084], 'Wolff': [1086, 2386], 'Namiki': [1088, 2388], 'pathways,': [1089, 1987], 'respectively,': [1090], 'can': [1091, 1627, 1690, 2134, 2903], 'significantly': [1092, 1628, 2498], 'complicate': [1093], 'vitro': [1095, 1482], 'experiments': [1096, 2359, 3431, 3883, 3896, 4020], 'study': [1099, 3049], 'Interrupted': [1122, 3940, 4018], 'methods': [1124, 3635, 3691, 3763, 4094], 'developed': [1127], 'Booth': [1129, 2296], 'et': [1130, 2297, 2937, 3664, 3694, 3766, 4097], 'al.': [1131, 2298, 2938, 3665, 3695, 3767, 4098], 'Scholar)': [1155, 1929, 2322, 2466, 2960, 3716, 3787], 'allow': [1157], 'Amadori-rich': [1158], 'proteins': [1159], 'isolated.': [1162], 'method': [1164, 3999], 'allows': [1165], 'more': [1166, 2428], 'detailed': [1167], 'studies': [1168], 'carried': [1171], 'out,': [1172], 'provide': [1175, 1904, 3179], 'insight': [1176, 3181], 'into': [1177, 3182], 'specific': [1179, 1260, 3917], 'mechanisms': [1180, 1432, 2065], 'involved': [1181, 1983], 'AGEs.': [1186], 'Generally,': [1187], 'alters': [1189], 'physicochemical': [1191, 1218], 'properties': [1192], 'forming': [1194], 'cross-links,': [1198], 'browning': [1199], '(nonfluorescent': [1200], 'AGE),': [1201], 'fluorescent': [1203, 1373, 2495], 'products.': [1205], 'Much': [1206], 'research': [1207, 1873], 'focused': [1209], 'on': [1210, 2481, 3360, 3906, 3930, 4173], 'investigating': [1211], 'assessing': [1215], 'nonspecific': [1217], 'properties,': [1219], 'procedures': [1222], 'questioned': [1225], '(10Miyata': [1226, 1275, 2665, 4099], 'Ueda': [1233, 1282, 2553, 2672, 4106], 'Y.': [1234, 1283, 2554, 2558, 2673, 4107], 'Ichimori': [1235, 1284, 2674, 4108], 'Inagi': [1237, 1286, 2559, 2676, 4110], 'Onogi': [1239, 1288, 2678, 4112], 'H.': [1240, 1289, 2679, 4113], 'Ishikawa': [1241, 1290, 2680, 4114], 'N.': [1242, 1291, 2681, 4115], 'Nangaku': [1243, 1292, 2682, 4116], 'M.': [1244, 1293, 1912, 2683, 3639, 4117], '2002;': [1251, 1300, 1820, 1859, 2690, 2766, 2794, 3117, 4124], '13:': [1252, 1301, 2691, 3137, 4125], '2478-2487Crossref': [1253, 1302, 2692, 4126], '(280)': [1256, 1305, 2695, 4129], 'Two': [1259], 'commonly': [1263], 'analyzed': [1264], 'ϵ-carboxymethyl': [1270], 'lysine': [1271], '11Weiss': [1308], 'M.F.': [1309], 'Erhard': [1310], 'Kader-Attia': [1312], 'F.A.': [1313], 'Wu': [1314], 'Y.C.': [1315], 'DeOreo': [1316], 'P.B.': [1317, 2036], 'Araki': [1318], 'Glomb': [1320], 'Monnier': [1322, 1422, 1658, 1705], 'V.M.': [1323, 1423, 1580, 1659, 1706], 'Kidney': [1324], 'Int.': [1325, 1643, 1766, 1818, 1998], '57:': [1327], '2571-2585Abstract': [1328], '(137)': [1336], 'Quantitatively,': [1339], 'major': [1346, 1385], 'chemically': [1347], 'characterized': [1348], 'oxidatively': [1349], 'formed': [1350, 1798], '(glycoxidation)': [1352, 1489], '(12Dunn': [1354], 'J.A.': [1355, 1399, 3771], 'Patrick': [1356], 'J.S.': [1357], 'Biochemistry.': [1362], '1989;': [1363, 2870], '9464-9468Crossref': [1365], '(230)': [1368], 'highly': [1372], 'lysine-arginine': [1374], 'cross-linked': [1375], 'pentosidine,': [1377], 'one': [1382], 'contributors': [1386], 'related': [1389], 'increases': [1390], 'blue': [1392], '(350–400': [1393], 'nm)': [1394, 3574, 4172, 4197, 4203], 'fluorescence': [1395, 3102, 4167], '(13Dyer': [1396, 3768], 'D.G.': [1397, 3769], 'Blackledge': [1398, 3770], '1991;': [1407, 1602, 1710, 3779], '266:': [1408, 1711, 3780], '11654-11660Abstract': [1409, 3781], '14Odetti': [1416], 'Fogarty': [1418], 'Sell': [1420], 'D.R.': [1421], 'Diabetes.': [1424], '1992;': [1425], '41:': [1426, 1821], '153-159Crossref': [1427], 'Specific': [1431], 'late': [1435], 'conversion': [1438], 'initial': [1441], 'adducts': [1443], 'involve': [1450], 'complex': [1451, 2478, 2733], 'sequential': [1452], 'parallel': [1454], 'completely': [1459], 'understood': [1460, 2071], 'typically': [1484, 3600], 'accelerated': [1485], 'conditions': [1488, 1613, 1626, 1759, 1991], 'using': [1490, 2292, 4192], 'Fe3+': [1495], 'Cu2+': [1497], '15Mowri': [1520], 'H.-O.': [1521], 'Frei': [1522], 'B.': [1523], 'Keaney': [1524], 'Jr.,': [1525], 'J.F.': [1526], '29:': [1532], '814-824Crossref': [1533], '(30)': [1536], 'It': [1539], 'generally': [1541], 'accepted': [1542], 'play': [1548], 'they': [1558], 'catalyze': [1562], 'electron': [1563], 'transfer': [1564], 'from': [1565, 1696, 1799, 2234, 3416, 3503, 4083], 'ene-diol': [1566], '(or': [1567], 'enaminol)': [1568], 'intermediates,': [1569], 'leads': [1571], 'generation': [1574, 1829], 'superoxide': [1576, 1908], 'α-dicarbonyls': [1578], '(16Monnier': [1579], 'Clin.': [1582, 1944, 1962, 2019, 3134], 'Investig.': [1583], '2001;': [1584, 1730, 2401, 2454, 2621, 2953], '107:': [1585], '799-801Crossref': [1586], '(55)': [1589], '17Wolff': [1592], 'S.P.': [1593], 'Jiang': [1594], 'Z.Y.': [1595], 'Hunt': [1596], 'J.V.': [1597], '10:': [1603], '339-352Crossref': [1604], '(797)': [1607], 'For': [1610, 1896, 2484], 'example,': [1611, 1897, 2485, 2912], 'intermediate': [1622], 'glyoxal,': [1623], 'nonoxidative': [1625, 1758, 1990], 'decrease': [1629, 2491, 2502, 2980], 'amount': [1631, 3859], 'lysine-glyoxal-derived': [1634], '(18Litchfield': [1637, 1760, 1992], 'J.E.': [1638, 1761, 1993], 'Cell': [1646, 1769, 2001], '31:': [1649, 1772, 2004], '1297-1305Crossref': [1650, 1773, 2005], '(36)': [1653, 1776, 2008], '19Glomb': [1656], '1995;': [1663, 2042], '270:': [1664, 2043], '10017-10026Abstract': [1665], '(516)': [1673], 'Pentosidine': [1676, 4078, 4163], 'marker': [1686], 'glycoxidation': [1688, 3362], 'reasonably': [1691], 'arise': [1695], '3-deoxyosone': [1698], '(hexose': [1699], 'pentose)': [1701], 'precursor': [1702, 1803], '(20Grandhee': [1703], 'S.K.': [1704], '11649-11653Abstract': [1712], '21Biemel': [1719], 'K.M.': [1720, 1811, 1851, 2786], 'Reihl': [1721], 'O.': [1722], 'Conrad': [1723, 1812], 'Lederer': [1725, 1814, 1854, 2787], 'M.O.': [1726, 1815, 1855, 2788], '276:': [1731, 2402, 2455, 2622], '23405-23412Abstract': [1732], '(124)': [1740], 'However,': [1743, 1972, 2290, 2507, 2634, 2819], 'pentose,': [1750], 'arabinose,': [1751], 'comparable': [1753], 'under': [1754, 1989, 3818, 3947, 4041, 4138], 'both': [1755, 2544, 2725], 'suggested': [1780, 1935], 'possible': [1782], 'non–Metal-dependent': [1785], 'redox': [1787, 1882, 1973], 'formation.': [1791, 2244], 'mechanism': [1793, 2471], '6-(2-hydroxy-4,5-dioxo-pentyl)-l-lysinate': [1805], 'recently': [1807], 'elucidated': [1809], '(22Biemel': [1810], 'Angew.': [1816], 'Ed.': [1819], '801-804Crossref': [1822], '(53)': [1825], 'this': [1831, 2508], 'dideoxyosone': [1833], 'requires': [1834], 'shifts': [1836], 'along': [1837], 'entire': [1839], 'carbohydrate': [1840], 'backbone': [1841], 'opens': [1843, 2650], 'new': [1844, 3145], 'possibilities': [1845], 'considering': [1847], 'degradation': [1849], '(23Biemel': [1850], 'Friedl': [1852], 'D.A.': [1853, 2940], '277:': [1860, 2767], '24907-24915Abstract': [1861], '(181)': [1869], 'suggests': [1874], 'intermediates': [1877, 1899, 1979, 2271, 2730, 2754], 'participate': [1879], 'directly': [1880, 2933], 'chemistry': [1883, 1974], 'radicals': [1887], 'without': [1888, 3420], 'requirement': [1890], 'catalysis.': [1895], 'enaminol': [1898], 'proposed': [1902], '“metal-free”': [1905], '(24Mossine': [1909], 'V.V.': [1910], 'Linetsky': [1911], 'Glinsky': [1913], 'G.V.': [1914], 'Ortwerth': [1915], 'B.J.': [1916], 'Feather': [1917], 'M.S.': [1918], 'Toxicol.': [1921], '12:': [1923], '230-236Crossref': [1924], '(79)': [1927], '(although': [1930], 'alternative': [1931], 'interpretations': [1932], '(25Baker': [1936], 'J.R.': [1937, 1955, 2012], 'Zyzak': [1938, 1956, 2013], 'D.V.': [1939, 1957, 2014], '1993;': [1946], '39:': [1947], '2460-2465Crossref': [1948], '(35)': [1951], '26Baker': [1954, 2011], '1994;': [1964, 2021], '40:': [1965, 2022], '1950-1955Crossref': [1966, 2023], '(76)': [1969, 2026], 'Scholar)).': [1971], 'two': [1976, 3889, 3907], '27Yim': [2029], 'H.-S.': [2030], 'Kang': [2031], 'S.-O.': [2032], 'Hah': [2033], 'Y.-C.': [2034], 'Chock': [2035], 'Yim': [2037], 'M.B.': [2038], '28228-28233Abstract': [2044], '(252)': [2052], 'Although': [2055], 'identified,': [2063], 'their': [2064, 2198, 2433], 'action': [2067, 2473], 'well': [2070], '(28Costantino': [2072], 'L.': [2073, 2948, 3132], 'Rastelli': [2074], 'G.': [2075, 2079, 2944], 'Vianello': [2076], 'Cignarella': [2078], 'Barlocco': [2080], 'Rev.': [2084], '19:': [2086], '3-23Crossref': [2087], '(182)': [2090, 2106], '29Thornalley': [2093], 'P.J.': [2094], 'Yurek-George': [2095], 'Argirov': [2097], 'O.K.': [2098], 'Pharmacol.': [2100, 3135], '60:': [2102], '55-65Crossref': [2103], 'most': [2110, 2225], 'common': [2111], 'feature': [2112], 'among': [2113], 'date': [2119], 'nucleophilic': [2125, 3054], 'functionality,': [2126], 'amine': [2130, 3055], 'hydrazone,': [2132], 'intercept': [2135], '(6Baynes': [2145], '(diethylenetriaminepentaacetic': [2188], '(DTPA))': [2190], '(α-tocopherol': [2194], 'ascorbate)': [2196], 'exhibit': [2197], 'activity': [2199], 'acceleration': [2203], 'reasonable': [2226], 'point': [2227, 3001], 'inhibit': [2232], 'pharmaceutical': [2236], 'standpoint': [2237], 'would': [2238], 'block': [2241, 2254], 'aminoguanidine': [2248], '(AG)': [2249], 'initially': [2251], 'at': [2256, 3596, 3756, 3815, 3887, 3924, 3935, 3955, 3983, 4038, 4064, 4073], 'several': [2257], 'points': [2258, 2374], 'dicarbonyls,': [2266], 'products,': [2268], 'methods,': [2295], 'able': [2324], 'demonstrate': [2326], 'AG': [2328, 2355, 2580, 2643], 'provided': [2329], 'little': [2330], 'formation,': [2335], 'whereas': [2336], '(PM)': [2338], 'identified': [2340], 'effective': [2343, 2376, 2838], 'inhibitor.': [2346, 2483], 'primarily': [2351], 'compared': [2353], 'ions,': [2366], 'makes': [2368], 'it': [2369, 2416, 2834, 2931, 3317], 'difficult': [2370, 2418], 'determine': [2372], 'complicating': [2385], '(30Price': [2390, 2443, 2610], 'D.L.': [2391, 2444, 2611], 'Rhett': [2392, 2445, 2612], 'P.M.': [2393, 2446, 2613], '48967-48972Abstract': [2403, 2456, 2623], '(286)': [2411, 2464, 2631], 'In': [2414], 'fact,': [2415], 'discern': [2420], 'literature': [2423], 'whether': [2424], 'some': [2425, 3542], 'promising': [2429], 'owe': [2432], 'activities': [2434], 'trapping': [2437, 2600, 2661, 2889, 2990, 3148], 'chelation': [2442], '(Structure': [2467], '1).': [2468], 'Overall,': [2469, 3350], 'dependent': [2480], 'PM': [2486, 2582, 2820, 3011, 3073], 'reported': [2489, 2537, 2823], 'specifically': [2500, 2539], 'CML.': [2506], 'inhibitor': [2509, 2536, 2706, 3902], 'did': [2510], 'lower': [2512, 2880, 2895, 2995, 3320], 'OPB-9195': [2550], '(31Miyata': [2551], 'Asahi': [2555], 'Izuhara': [2557], 'Saito': [2561], '1719-1725PubMed': [2576], 'Both': [2579, 3060], 'less': [2584], 'active': [2585], 'than': [2589, 3072, 3310, 3321], 'OPB-9195,': [2590, 2645], 'each': [2592], 'evidence': [2597], 'via': [2601], 'triazine,': [2604], 'amide,': [2605], 'hydrazone': [2607], 'adducts,': [2608], 'respectively': [2609], 'use': [2636], 'retard': [2647], 'risk': [2653], 'pyridoxal': [2655], 'deficiency': [2656], 'indiscriminately': [2660], 'necessary': [2662], 'species': [2664], 'present': [2699, 3175, 3864], 'describes': [2701], 'antioxidant': [2719, 2839, 2929], 'addresses': [2721], 'involvement': [2723], 'carbonyls': [2727], 'reaction.': [2738], 'Considering': [2739], 'carbonyl-trapping': [2743], 'found': [2749, 3065], 'bound': [2750], 'important': [2752], '(32Voziyan': [2755], 'P.A.': [2756], 'Metz': [2757], 'T.O.': [2758], '3397-3403Abstract': [2768], '(194)': [2776], '33Nagaraj': [2779], 'R.H.': [2780], 'Sarkar': [2781], 'Mally': [2783], 'Biemel': [2785], 'Padayatti': [2789], 'P.S.': [2790], 'Arch.': [2791, 3640], '402:': [2795], '110-119Crossref': [2796], '(151)': [2799], 'Scholar),': [2801, 3091], 'we': [2802], 'suspected': [2803], 'phenol': [2806, 2901], 'functionality': [2807], 'might': [2808], 'serve': [2809], 'local': [2812], 'protective': [2813], 'agent': [2814], 'against': [2815, 3976], 'intermediates.': [2818], 'weak': [2827], 'hydrogen': [2828], 'atom': [2829], 'donating': [2830], '(radical-trapping)': [2831], 'ability,': [2832], 'making': [2833], 'marginally': [2837], '(34Onorato': [2840], 'J.M.': [2841], 'Jenkins': [2842], 'A.J.': [2843], '275:': [2852], '21177-21184Abstract': [2853], '(234)': [2861], '35DeLange': [2864], 'R.J.': [2865], 'Glazer': [2866], 'A.N.': [2867], 'Anal.': [2868, 4008], '177:': [2871], '300-306Crossref': [2872], '(168)': [2875], 'Electron-donating': [2878], 'para-substituents': [2879], 'O–H': [2882, 2982], 'bond': [2883, 2983], 'dissociation': [2884, 2984], 'enthalpies,': [2885], 'enhances': [2887], 'rates.': [2890], 'Unfortunately,': [2891], 'substituents': [2893], 'do': [2904, 2993], 'so': [2905], 'extent': [2909], 'that,': [2910], '4-dimethylaminophenol': [2913], '(which': [2914], 'should': [2915], 'extremely': [2918], 'good': [2919], 'trap)': [2921], 'no': [2924, 3467, 3528], 'practical': [2925], 'value': [2926], 'reacts': [2932], 'dioxygen.': [2935], 'Pratt': [2936], '(36Pratt': [2939], 'DiLabio': [2941], 'G.A.': [2942], 'Brigati': [2943], 'Pedulli': [2945], 'G.F.': [2946], 'Valgimigli': [2947], '123:': [2954], '4625-4626Crossref': [2955], '(156)': [2958], 'shown': [2962], 'electron-donating': [2965], 'groups': [2966], '(such': [2967], 'dimethylamino)': [2969], 'para': [2970], 'hydroxyl': [2974], '3-pyridinols': [2977], '5-pyrimidinols': [2979], 'enthalpy': [2985], 'greatly': [2987], 'rates': [2991], 'oxygen.': [3009], 'Therefore,': [3010], 'modified': [3013, 4003], 'addition': [3016, 3509], '6-dimethylamino': [3019], 'substituent': [3020], '(6-dimethylaminopyridoxamine,': [3021], 'dmaPM)': [3022], '(59Culbertson': [3023, 3076, 3666], 'S.M.': [3024, 3077, 3667], 'Enright': [3025, 3078, 3668], 'G.D.': [3026, 3079, 3669], 'Ingold': [3027, 3080, 3670], 'K.U.': [3028, 3081, 3671], 'Organic': [3029, 3082, 3672], 'Lett.': [3030, 3083, 3673], '2003;': [3031, 3084, 3674], '5:': [3032, 3085, 3675], '2659-2662Crossref': [3033, 3086, 3676], '(27)': [3036, 3089, 3679], 'A': [3039, 4226], '(PN)': [3041], 'derivative': [3042], '(6-dimethylaminopyridoxine,': [3043], 'dmaPN)': [3044], 'tested': [3047, 3162, 3561], 'importance': [3051], 'reactions.': [3059], 'dmaPN': [3063, 3658], 'much': [3068], 'better': [3069], 'PN': [3075, 4193], 'evaluated': [3093], 'following': [3095], 'peroxyl': [3097], 'radical-induced': [3098], 'quenching': [3099], 'allophycocyanin': [3101], '(37Nakagawa': [3103], 'Yokozawa': [3105], 'Terasawa': [3107], 'Shu': [3109], 'S.': [3110], 'Juneja': [3111], 'L.R.': [3112], 'Agric.': [3114], 'Food': [3115], '50:': [3118], '2418-2422Crossref': [3119], '(175)': [3122], '38Courderot-Masuyer': [3125], 'Dalloz': [3127], 'F.': [3128], 'Maupoil': [3129], 'V.': [3130], 'Rochette': [3131], 'Fundam.': [3133], '535-540Crossref': [3138], '(64)': [3141], 'number': [3156], '(+M': [3166, 3456], 'buffer)': [3167, 3172, 3457, 3481, 4031], '(–M': [3171, 3480], 'experiments.': [3173, 3546, 3857], 'We': [3174], 'mechanistic': [3180], 'inhibiting': [3183], 'comparing': [3188], 'inhibitors:': [3194], 'antioxidants.': [3203], 'counterintuitive': [3212], 'agent,': [3268], 'higher': [3309], 'control,': [3315], 'although': [3316], 'still': [3319], 'control.': [3326], 'limited': [3339], 'our': [3351], 'findings': [3352], 'show': [3353], 'phenomenal': [3355], 'impact': [3356], 'Reagents—Chemicals': [3413], 'purchased': [3415], 'Sigma-Aldrich': [3417], 'further': [3421], 'purification': [3422], 'unless': [3423, 3825, 3964], 'otherwise': [3424, 3826, 3965], 'noted.': [3425], 'All': [3426, 3547], 'water': [3427], 'deionized': [3433], 'treated': [3435], 'Millipore': [3438], 'Milli-Q': [3439], 'plus': [3440], 'system': [3441], '(18': [3442], 'mΩ).': [3443], 'Monobasic': [3444], 'dibasic': [3446], 'sodium': [3447], 'phosphate': [3448, 3462, 3486, 3747, 4145], 'salts': [3449], 'SigmaUltra': [3451], 'grade.': [3452], 'Metal': [3453, 3477], '0.2': [3460, 3484, 4143, 4148], 'm': [3461, 3485, 3746, 4144], 'buffer,': [3463, 3487, 3963], 'pH': [3464, 3488, 3751, 4150], '7.4,': [3465, 3489], 'treatment': [3468], 'remove': [3470], 'ions.': [3476], 'stirred': [3492], 'Chelex-100': [3494], 'resin': [3495, 3505], '(Bio-Rad)': [3496], '24': [3498, 3959, 3990], 'h': [3499, 3755, 3960], 'then': [3501], 'removed': [3502, 3923, 4063], 'prior': [3506], 'DTPA': [3515], '(1': [3516, 3521], 'mm)': [3517, 3831, 4052], 'phytic': [3519, 3534], 'mm).': [3522, 3840], 'Chelex-100-treated': [3523], '(Chelex': [3525], 'only)': [3526], 'added': [3529, 3849, 3877], 'chelating': [3530], 'agents': [3531], '(DTPA': [3532], 'acid)': [3535], 'prepared': [3538, 3687, 4090], 'dilutions': [3543], 'buffers': [3549, 3559], 'filtered': [3551], '(0.45-μm': [3552], 'Gelman': [3553], 'GHP': [3554], 'Acrodisk)': [3555], 'before': [3556], 'use.': [3557], 'impurities': [3569], 'ascorbate': [3571], 'autoxidation': [3572], '(266': [3573], 'according': [3575, 3632, 3661, 3688, 4091], 'Buettner': [3577], '(39Buettner': [3578], 'G.R.': [3579], 'Methods.': [3583], '1988;': [3584], '16:': [3585], '27-40Crossref': [3586], '(434)': [3589], 'Ascorbate': [3592, 3614], 'loss': [3593, 3616], '(15': [3594], 'min': [3595, 4218], 'room': [3597], 'temperature)': [3598], '∼47%': [3601], '±': [3602, 3609, 3623], '9%': [3603], '+M': [3605, 3810, 3855, 3962, 3978, 4028], '∼0.7': [3608], '0.2%': [3610], '–M': [3612, 3813, 3852, 3981, 4033], 'buffer.': [3613], 'test': [3615], 'Chelex': [3618, 3845, 3861], '∼2.8': [3622], '0.7%': [3624], '15': [3626], 'min.': [3627], 'Dipyridoxylamine': [3628], '(diPM)': [3629], 'synthesized': [3631, 3660, 3727], 'Ikawa': [3637], '(40Ikawa': [3638], '1967;': [3643], '118:': [3644], '497-500Crossref': [3645], '(25)': [3648], 'vitamin': [3653], 'B6': [3654], 'derivatives': [3655], 'Culbertson': [3663], 'internal': [3683, 4205], 'standard': [3684], 'tetra-deuterio-CML': [3685], 'Ahmed': [3693], '(41Ahmed': [3696], 'M.U.': [3697], 'Brinkmann': [3698], 'Frye': [3699], 'Degenhardt': [3701], '324:': [3710], '565-570Crossref': [3711], '(531)': [3714], 'minor': [3719, 3790], 'Di-N-acetyl-pentosidine': [3724], '(Ac-Pt)': [3725], 'α-acetyllysine': [3733], '(6.2': [3734, 3737, 3742], 'mmol),': [3735, 3738], 'α-acetylarginine': [3741], 'mmol)': [3743], '0.5': [3745], '(62': [3749], 'ml),': [3750], '9.0,': [3752], '48': [3754], '60': [3757], '°C': [3758, 3937, 3957, 3985, 4075], 'purified': [3760], 'Dyer': [3765], 'Uninterrupted': [3795], 'Glycation—Bovine': [3796], 'albumin': [3798], '(BSA)': [3799], '(10': [3800, 3943], 'mg/ml)': [3801, 3944, 4026], 'essentially': [3802], 'fatty': [3805], 'acids': [3806], 'glycated': [3808], '37': [3816, 3956, 4039], '°C,': [3817, 4040], 'air,': [3819, 3948, 4042], 'either': [3821, 3851, 3977], 'd(–)-ribose': [3822], '(50': [3823, 4087], 'mm,': [3824], 'indicated)': [3827], 'd(+)-glucose': [3829], '(250': [3830], 'absence': [3834, 4045], '(0.2–25': [3839], '(Inhibitors': [3841], 'dissolved': [3843, 4141], '(10%': [3865], 'v/v)': [3866, 3875], 'kept': [3868], 'constant': [3869], 'experiments.)': [3872], 'Toluene': [3873], '(1%,': [3874], 'bacterial': [3880], 'growth.': [3881], 'Most': [3882], 'performed': [3885, 3905], 'least': [3888], 'side': [3890, 3892], 'reactions;': [3893], 'however,': [3894], 'many': [3895], '(typically,': [3897], 'control': [3898], '5': [3900, 4069], 'mm': [3901, 4188], 'experiments)': [3903], 'separate': [3910, 4232], 'occasions': [3911], 'figure': [3913], 'legends': [3914], 'numbers': [3918], 'experiments).': [3920], 'Aliquots': [3921], 'various': [3925, 4049], 'intervals': [3926], '(3–21': [3927], 'days)': [3928], 'depending': [3929], 'frozen': [3934, 4072], '–75': [3936, 4074], 'until': [3938, 4076], 'analyses.': [3939, 4077], 'Ribose': [3941], 'Glycation—BSA': [3942], 'preglycated,': [3946, 4022], 'incubation': [3950, 4085], '(0.5': [3953], 'm)': [3954], 'indicated.': [3966], 'portions': [3968], 'dialyzed': [3970, 4023], '(molecular': [3971], 'cut-off,': [3973], '12': [3974], 'kDa)': [3975], '4': [3984], '(4': [3986], 'changes': [3988], 'over': [3989], 'h).': [3991], 'concentrations': [3994], 'determined': [3996], 'Lowry': [4001], 'Peterson': [4005], '(42Peterson': [4006], 'G.L.': [4007], '1977;': [4010], '83:': [4011], '346-356Crossref': [4012], '(7113)': [4015], 'BSA': [4024], '(5': [4025, 4051, 4179], '((+M)/+M': [4030], '((+M)/–M)': [4035], 'incubated': [4037], '(the': [4053], 'samples': [4054, 4082], 'contained': [4056], 'toluene,': [4057], '1%': [4058], 'v/v).': [4059], 'aliquots': [4061], '0,': [4065], '1,': [4066], '3.5,': [4067], 'days': [4070], 'Analysis': [4079], 'HPLC—The': [4081], 'mixtures': [4086], 'μl)': [4088], 'Miyata': [4096], 'hydrolysates': [4133], 'evaporated': [4135], 'dryness': [4137], 'nitrogen': [4139], '(filtered': [4147], 'μm),': [4149], '7.4': [4151], '(400': [4152], '100': [4154], 'μl': [4155], 'samples,': [4161], 'respectively).': [4162], 'quantified': [4165], 'detection': [4168], '(excitation/emission': [4169, 4194, 4200], '=': [4170, 4195, 4201], '336/385': [4171, 4202, 4215], 'Discovery': [4175], 'C18': [4176], 'HPLC': [4177], 'column': [4178], 'μm': [4180], 'partide': [4181], 'size,': [4182], '25': [4183], 'cm': [4184], 'length': [4185], '×': [4186], '4.6': [4187], 'inner': [4189], 'diameter;': [4190], 'Supelco)': [4191], '305/395': [4196, 4222], 'Ac-Pt': [4199], 'standards': [4206], '(fluorescence': [4207], 'detector,': [4208], '370-nm': [4209], 'emission': [4210], 'cut-off;': [4211], 'excitation/emission': [4212], 'time': [4213], 'program,': [4214], 'nm': [4216, 4223], '0–15': [4217], '25–60': [4220], 'min;': [4221], '15–25': [4224], 'min).': [4225], 'gradient': [4227], 'program': [4228]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994636910', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-15T16:06:48.408752', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
