Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1994633554', 'doi': 'https://doi.org/10.1111/j.1349-7006.2006.00304.x', 'title': 'Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats', 'display_name': 'Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats', 'publication_year': 2006, 'publication_date': '2006-08-22', 'ids': {'openalex': 'https://openalex.org/W1994633554', 'doi': 'https://doi.org/10.1111/j.1349-7006.2006.00304.x', 'mag': '1994633554', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16925582'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1349-7006.2006.00304.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S175946340', 'display_name': 'Cancer Science', 'issn_l': '1347-9032', 'issn': ['1347-9032', '1349-7006'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159268', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5091759375', 'display_name': 'Yoshihiko Shibayama', 'orcid': 'https://orcid.org/0000-0002-3912-3345'}, 'institutions': [{'id': 'https://openalex.org/I107139324', 'display_name': 'Kagoshima University', 'ror': 'https://ror.org/03ss88z23', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I107139324']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshihiko Shibayama', 'raw_affiliation_strings': ['Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan', 'institution_ids': ['https://openalex.org/I107139324']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023917654', 'display_name': 'Kazami Ushinohama', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107139324', 'display_name': 'Kagoshima University', 'ror': 'https://ror.org/03ss88z23', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I107139324']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazami Ushinohama', 'raw_affiliation_strings': ['Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan', 'institution_ids': ['https://openalex.org/I107139324']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017035937', 'display_name': 'Ryuji Ikeda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107139324', 'display_name': 'Kagoshima University', 'ror': 'https://ror.org/03ss88z23', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I107139324']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryuji Ikeda', 'raw_affiliation_strings': ['Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan', 'institution_ids': ['https://openalex.org/I107139324']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061868058', 'display_name': 'Yoshimi Yoshikawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107139324', 'display_name': 'Kagoshima University', 'ror': 'https://ror.org/03ss88z23', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I107139324']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoshimi Yoshikawa', 'raw_affiliation_strings': ['Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan', 'institution_ids': ['https://openalex.org/I107139324']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5027568235', 'display_name': 'Toshiro Motoya', 'orcid': 'https://orcid.org/0000-0003-2717-6367'}, 'institutions': [{'id': 'https://openalex.org/I11023767', 'display_name': 'Kyushu University of Health and Welfare', 'ror': 'https://ror.org/01banz567', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I11023767']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshiro Motoya', 'raw_affiliation_strings': ['First Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714‐1 Yoshino‐cho, Nobeoka, 882–8508, Japan'], 'affiliations': [{'raw_affiliation_string': 'First Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714‐1 Yoshino‐cho, Nobeoka, 882–8508, Japan', 'institution_ids': ['https://openalex.org/I11023767']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090907927', 'display_name': 'Yasuo Takeda', 'orcid': 'https://orcid.org/0000-0001-7210-5096'}, 'institutions': [{'id': 'https://openalex.org/I107139324', 'display_name': 'Kagoshima University', 'ror': 'https://ror.org/03ss88z23', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I107139324']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yasuo Takeda', 'raw_affiliation_strings': ['Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan', 'institution_ids': ['https://openalex.org/I107139324']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101144723', 'display_name': 'Katsushi Yamada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107139324', 'display_name': 'Kagoshima University', 'ror': 'https://ror.org/03ss88z23', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I107139324']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Katsushi Yamada', 'raw_affiliation_strings': ['Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan', 'institution_ids': ['https://openalex.org/I107139324']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2250, 'currency': 'USD', 'value_usd': 2250, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.273, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 43, 'citation_normalized_percentile': {'value': 0.910595, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '97', 'issue': '11', 'first_page': '1260', 'last_page': '1266'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Mechanisms of Multidrug Resistance in Cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12229', 'display_name': 'Prenatal Exposure to Antiepileptic Drugs', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11964', 'display_name': 'Effects of Medication on Pregnancy Outcomes', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/abcg2', 'display_name': 'Abcg2', 'score': 0.7630338}, {'id': 'https://openalex.org/keywords/antifolate', 'display_name': 'Antifolate', 'score': 0.65510416}, {'id': 'https://openalex.org/keywords/pregnane-x-receptor', 'display_name': 'Pregnane X receptor', 'score': 0.57560056}, {'id': 'https://openalex.org/keywords/metabolic-regulation', 'display_name': 'Metabolic Regulation', 'score': 0.531425}, {'id': 'https://openalex.org/keywords/atp-dependent-transporters', 'display_name': 'ATP-dependent Transporters', 'score': 0.527735}, {'id': 'https://openalex.org/keywords/probenecid', 'display_name': 'Probenecid', 'score': 0.49863958}], 'concepts': [{'id': 'https://openalex.org/C36201501', 'wikidata': 'https://www.wikidata.org/wiki/Q17907816', 'display_name': 'Multidrug resistance-associated protein 2', 'level': 5, 'score': 0.97352135}, {'id': 'https://openalex.org/C123584848', 'wikidata': 'https://www.wikidata.org/wiki/Q18034026', 'display_name': 'Organic anion transporter 1', 'level': 4, 'score': 0.88248545}, {'id': 'https://openalex.org/C512196', 'wikidata': 'https://www.wikidata.org/wiki/Q4650095', 'display_name': 'Abcg2', 'level': 5, 'score': 0.7630338}, {'id': 'https://openalex.org/C2781382166', 'wikidata': 'https://www.wikidata.org/wiki/Q50573407', 'display_name': 'Antifolate', 'level': 4, 'score': 0.65510416}, {'id': 'https://openalex.org/C2781059491', 'wikidata': 'https://www.wikidata.org/wiki/Q422232', 'display_name': 'Methotrexate', 'level': 2, 'score': 0.62743664}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.61299247}, {'id': 'https://openalex.org/C132040763', 'wikidata': 'https://www.wikidata.org/wiki/Q409867', 'display_name': 'Pregnane X receptor', 'level': 5, 'score': 0.57560056}, {'id': 'https://openalex.org/C2776769776', 'wikidata': 'https://www.wikidata.org/wiki/Q900898', 'display_name': 'Probenecid', 'level': 2, 'score': 0.49863958}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.4247827}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.40974241}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3271261}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.28339368}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.27679116}, {'id': 'https://openalex.org/C2778397455', 'wikidata': 'https://www.wikidata.org/wiki/Q50429865', 'display_name': 'Antimetabolite', 'level': 3, 'score': 0.2556635}, {'id': 'https://openalex.org/C44312359', 'wikidata': 'https://www.wikidata.org/wiki/Q286958', 'display_name': 'ATP-binding cassette transporter', 'level': 4, 'score': 0.18532899}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.11544901}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.052663565}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018528', 'descriptor_name': 'ATP-Binding Cassette Transporters', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000964', 'descriptor_name': 'Antimetabolites, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008727', 'descriptor_name': 'Methotrexate', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D027362', 'descriptor_name': 'Organic Anion Transport Protein 1', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D029362', 'descriptor_name': 'Organic Anion Transporters, Sodium-Independent', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D000070997', 'descriptor_name': 'ATP Binding Cassette Transporter, Subfamily G, Member 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002955', 'descriptor_name': 'Leucovorin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017208', 'descriptor_name': 'Rats, Wistar', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014803', 'descriptor_name': 'Vitamin B Complex', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1349-7006.2006.00304.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S175946340', 'display_name': 'Cancer Science', 'issn_l': '1347-9032', 'issn': ['1347-9032', '1349-7006'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159268', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16925582', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159268', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.86, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1618268377', 'https://openalex.org/W1909111805', 'https://openalex.org/W1968605474', 'https://openalex.org/W1976185948', 'https://openalex.org/W1985770274', 'https://openalex.org/W1995297514', 'https://openalex.org/W2000278377', 'https://openalex.org/W2006268588', 'https://openalex.org/W2012021913', 'https://openalex.org/W2015618130', 'https://openalex.org/W2024357525', 'https://openalex.org/W2031580730', 'https://openalex.org/W2041656047', 'https://openalex.org/W2048541050', 'https://openalex.org/W2051819610', 'https://openalex.org/W2051860402', 'https://openalex.org/W2056728747', 'https://openalex.org/W2058859643', 'https://openalex.org/W2060297699', 'https://openalex.org/W2063648791', 'https://openalex.org/W2065701589', 'https://openalex.org/W2067650742', 'https://openalex.org/W2081152882', 'https://openalex.org/W2081213990', 'https://openalex.org/W2081750550', 'https://openalex.org/W2092296126', 'https://openalex.org/W2097551446', 'https://openalex.org/W2110790042', 'https://openalex.org/W2123467745', 'https://openalex.org/W2123772706', 'https://openalex.org/W2124117663', 'https://openalex.org/W2126777639', 'https://openalex.org/W2154283357', 'https://openalex.org/W2155568044', 'https://openalex.org/W2160553550', 'https://openalex.org/W2161816485', 'https://openalex.org/W2187001260', 'https://openalex.org/W2324137484', 'https://openalex.org/W261272532', 'https://openalex.org/W3131315330', 'https://openalex.org/W4233281129'], 'related_works': ['https://openalex.org/W4225255226', 'https://openalex.org/W2883664573', 'https://openalex.org/W2520115765', 'https://openalex.org/W2331321029', 'https://openalex.org/W2148998009', 'https://openalex.org/W2096956997', 'https://openalex.org/W2070133422', 'https://openalex.org/W2067808501', 'https://openalex.org/W2045724711', 'https://openalex.org/W1980440732'], 'abstract_inverted_index': {'The': [0, 87], 'ATP': [1], 'binding': [2], 'cassette': [3], '(ABC)': [4], 'transporters,': [5], 'multidrug': [6], 'resistance': [7, 15], 'protein': [8, 16], '2': [9], '(Mrp2;': [10], 'Abcc2)': [11], 'and': [12, 19, 29, 63, 77, 80, 92, 118, 132, 144, 154, 188, 197, 221, 237, 239], 'breast': [13], 'cancer': [14], '(Bcrp;': [17], 'Abcg2),': [18], 'organic': [20], 'anion': [21], 'transporters': [22], '(Oats)': [23], 'mediate': [24], 'excretion': [25], 'of': [26, 48, 55, 60, 74, 89, 108, 139, 159, 163, 183, 201, 216, 234], 'methotrexate': [27], '(MTX)': [28], 'many': [30], 'other': [31], 'drugs.': [32], 'However,': [33], 'it': [34], 'is': [35], 'not': [36, 121], 'known': [37], 'whether': [38], 'MTX': [39, 56, 67, 164, 175, 177, 207, 229], 'treatment': [40, 57, 99, 178, 208, 230], 'leads': [41], 'to': [42, 128, 149, 193], 'any': [43], 'changes': [44], 'in': [45, 65, 115, 122, 203], 'the': [46, 53, 98, 112, 116, 123, 204], 'expression': [47, 59, 214, 232], 'these': [49, 225], 'transporters.': [50], 'We': [51], 'examined': [52], 'effect': [54, 212], 'on': [58, 94, 213], 'Mrp2,': [61, 90, 235], 'Bcrp': [62], 'Oats': [64], 'rats.': [66], 'was': [68, 85], 'single': [69], 'injected': [70], 'intraperitoneally': [71], 'at': [72], 'doses': [73], '10,': [75], '50': [76], '150': [78, 109], 'mg/kg,': [79], 'then': [81], 'Western': [82], 'blot': [83], 'analysis': [84], 'performed.': [86], 'levels': [88, 114, 182, 215, 233], 'Oat1': [91, 143, 236], 'Oat2': [93], 'day': [95], '1': [96], 'after': [97, 106], 'showed': [100], 'no': [101, 210], 'significant': [102], 'change.': [103], 'Four': [104], 'days': [105], 'injection': [107], 'mg/kg': [110], 'MTX,': [111], 'Mrp2': [113], 'liver': [117], 'ileum,': [119], 'but': [120], 'kidney,': [124], 'were': [125, 146, 165], 'markedly': [126], 'down‐regulated': [127, 148], '20': [129], '±': [130, 134, 137, 151, 156, 195, 199], '3.6%': [131], '8.9': [133], '3.8%': [135], '(mean': [136], 'SEM)': [138], 'controls,': [140], 'respectively.': [141, 206], 'Renal': [142], 'Oat3': [145], 'also': [147, 179], '56.4': [150], '4.3%': [152], '(Oat1)': [153], '54.3': [155], '5.5%': [157], '(Oat3)': [158], 'controls.': [160], 'These': [161], 'effects': [162, 241], 'almost': [166], 'recovered': [167, 243], 'by': [168, 244], 'leucovorin': [169], 'which': [170], 'rescues': [171], 'normal': [172], 'cells': [173], 'from': [174], 'toxicity.': [176], 'decreased': [180], 'mRNA': [181], 'constitutive': [184], 'androstane': [185], 'receptor': [186, 191], '(CAR)': [187], 'pregnane': [189], 'X': [190], '(PXR)': [192], '65.5': [194], '17.9%': [196], '59.6': [198], '14.5%': [200], 'controls': [202], 'liver,': [205], 'has': [209], 'apparent': [211], 'Bcrp,': [217], 'cytochrome': [218], 'P450': [219], '2B6': [220], '3A1.': [222], 'In': [223], 'conclusion,': [224], 'data': [226], 'indicate': [227], 'that': [228], 'down‐regulates': [231], 'Oat3,': [238], 'its': [240], 'are': [242], 'leucovorin.': [245], '(': [246], 'Cancer': [247], 'Sci': [248], '2006;': [249], '97:': [250], '1260–1266)': [251]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994633554', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-08-15T07:44:58.476970', 'created_date': '2016-06-24'}