Publication Information

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2113, 2122, 2125, 2127, 2198, 2217, 2275, 2284, 2301, 2382, 2447, 2450, 2452, 2463, 2505, 2514, 2545, 2548, 2550, 2675, 2720, 2738, 2741, 2763, 2791, 2797, 2800, 2805, 2821, 2825, 2830, 2840, 2866, 2874, 2878, 2886, 2889, 2891, 2955, 2958, 2960, 2994, 3009, 3077, 3149, 3211, 3248, 3257, 3295, 3397, 3459, 3472, 3475, 3501, 3506, 3518, 3528, 3533, 3542, 3558, 3593, 3631, 3634, 3651, 3754, 3779, 3863, 3873, 3891, 3965, 3994, 4021, 4031, 4055, 4070, 4127, 4136, 4151, 4171, 4187, 4193, 4195, 4209, 4212, 4219, 4228, 4268, 4319, 4323, 4372, 4379, 4387, 4443, 4449, 4452, 4505, 4516, 4523, 4533], 'cytosol': [34, 191, 901, 3502], 'weakly': [36, 193], 'associated': [37, 66, 194, 223, 3504, 3526, 3598, 4191, 4266], 'as': [40, 71, 197, 228, 479, 649, 651, 1148, 1526, 2794, 2902, 3202, 3221, 3304, 3413, 3615, 3679, 3730, 3955, 3957, 4014, 4086, 4327], 'monomer': [42, 199], 'an': [44, 201, 859, 3642, 3656, 3976], 'apparent': [45, 202], 'molecular': [46, 74, 122, 203, 231, 279, 3660, 3689, 3732, 4046, 4058, 4096, 4488], 'mass': [47, 204, 3690, 4047, 4059], 'of': [48, 53, 77, 148, 205, 210, 234, 305, 351, 488, 500, 776, 836, 850, 1034, 1048, 1130, 1152, 1155, 1163, 1170, 1181, 1300, 1311, 1353, 1504, 1510, 1532, 1730, 1798, 2115, 2124, 2313, 2322, 2328, 2331, 2345, 2348, 2384, 2410, 2449, 2534, 2547, 2576, 2646, 2719, 2755, 2868, 2871, 2873, 2888, 2915, 2957, 2971, 2990, 3011, 3019, 3084, 3102, 3108, 3136, 3364, 3371, 3391, 3409, 3462, 3477, 3596, 3658, 3664, 3691, 3708, 3778, 3793, 3834, 3865, 3893, 3968, 3991, 4048, 4060, 4098, 4113, 4129, 4138, 4211, 4264, 4279, 4386, 4469, 4497, 4526], '20,000': [49, 206, 4049], 'Da.': [50, 207], 'After': [51, 208, 2748], 'treatment': [52, 209], 'cells': [56, 213, 1166, 1758, 2083, 2095, 2109, 2128, 2169, 2835, 2879, 2892, 2910, 3453, 3473, 3750, 4074, 4130, 4257, 4334, 4511], 'apoptosis': [59, 216, 1762, 4076, 4134, 4253, 4339], 'inducer': [60, 217, 1763], 'staurosporine': [61, 218, 1764, 2089, 2116, 3480, 4081], 'or': [62, 219, 1167, 1534, 1765, 2117, 2481, 3484, 3673, 4331], 'UV': [63, 220, 1766, 2097, 2119, 3486, 4259], 'irradiation,': [64, 221, 1767], 'two': [72, 229, 318, 1355, 4277], 'large': [73, 121, 230, 278, 1724, 4087, 4544], 'weight': [75, 123, 232, 280, 3733, 4489], 'oligomers/complexes': [76, 125, 233, 282], '96,000': [78, 235, 4101], '260,000': [80, 237, 3692, 4099], 'Da,': [81, 238, 4050], 'are': [83, 240, 629, 845, 1508, 1521, 1784, 4519, 4536], 'integrated': [84, 241], 'into': [85, 95, 242, 252, 401, 899, 1787, 1805, 2829, 3435], 'mitochondrial': [87, 97, 101, 110, 155, 244, 254, 258, 267, 312, 327, 341, 880, 1159, 1303, 1778, 1789, 1807, 2015, 2152, 2285, 2306, 2472, 2507, 2520, 2916, 3607, 3623, 3704, 3710, 3744, 3755, 3874, 3966, 4023, 4032, 4071, 4196, 4229, 4246, 4272, 4367, 4374, 4524], 'membrane.': [88, 98, 156, 245, 255, 313, 1790], 'prevents': [90, 247], 'oligomerization': [92, 130, 249, 287, 3833, 3864, 3899, 4263], 'insertion': [94, 251, 1804], 'The': [99, 256, 340, 486, 625, 769, 1032, 1118, 1307, 1342, 1457, 1502, 1781, 1811, 1975, 2168, 2193, 2212, 2223, 2230, 2248, 2279, 2360, 2470, 2501, 2519, 2560, 2578, 2602, 2661, 2716, 2770, 2786, 2849, 2977, 3004, 3031, 3065, 3140, 3266, 3336, 3621, 3775, 4111, 4214, 4316], 'outer': [100, 154, 257, 311, 1302, 4373], 'membrane': [102, 111, 259, 268, 1304, 1527, 1779, 1808, 2608, 3711, 3756, 3967, 4368, 4375, 4381, 4525], 'voltage-dependent': [104, 261, 2009], 'anion': [105, 262, 1843, 2010], 'channel': [106, 151, 263, 308, 1723, 2011], 'inner': [109, 266, 4380], 'adenosine': [113, 270, 2012], 'nucleotide': [114, 271, 1845, 2013], 'translocator': [115, 272, 2014], 'do': [116, 273], 'not': [117, 274, 3538, 3555, 3984, 4158, 4520], 'coelute': [118, 275], 'on': [126, 283, 1499, 2320, 2343, 2486, 2539, 2588, 2619, 2774, 3115, 3153, 3627, 3890, 3914, 4027, 4126, 4201, 4296], 'gel': [127, 284, 1841, 2006, 2666, 3628, 4028, 4297, 4453], 'filtration.': [128, 285, 4029], 'appears': [131, 288, 491, 854], 'be': [133, 290, 399, 493, 897, 1041], 'required': [134, 291], 'for': [135, 292, 646, 652, 1360, 2090, 2105, 2145, 2209, 2239, 2257, 2270, 2297, 2372, 2440, 2459, 2488, 2498, 2541, 2590, 2599, 2882, 2948, 2998, 3025, 3059, 3073, 3087, 3117, 3192, 3262, 3401, 3481, 3541, 4166, 4313, 4458, 4556], 'its': [136, 293, 4352], 'oligomer/complex': [142, 299], 'might': [143, 300, 3860], 'constitute': [144, 301], 'structural': [146, 303, 1362], 'entirety': [147, 304], 'cytochromec-conducting': [150, 307], 'Apoptosis': [314, 2077, 3467], 'mediated': [316], 'through': [317, 1294, 2186, 2197, 3566], 'major': [319, 4467, 4550], 'pathways,': [320], 'death': [322, 874], 'receptor': [323], 'pathway': [324, 328, 342], '(1Hengartner': [329], 'M.O.': [330, 1583], 'Nature.': [331, 449, 542, 1200, 1400, 1569, 4400], '2000;': [332, 987, 1019, 1068, 1329, 1707, 1744, 3850, 3930], '407:': [333], '770-776Crossref': [334], 'PubMed': [335, 361, 372, 390, 427, 444, 453, 517, 531, 546, 571, 600, 620, 671, 716, 736, 764, 809, 913, 930, 952, 971, 995, 1027, 1071, 1113, 1204, 1233, 1260, 1286, 1337, 1404, 1428, 1452, 1573, 1600, 1637, 1666, 1710, 1747, 1998, 2051, 3238, 3331, 3586, 3815, 3853, 3933, 4404, 4435], 'Scopus': [336, 391, 428, 454, 518, 532, 547, 572, 601, 621, 672, 697, 717, 737, 765, 810, 914, 931, 953, 972, 996, 1028, 1072, 1114, 1205, 1234, 1261, 1287, 1338, 1405, 1429, 1453, 1574, 1601, 1638, 1667, 1711, 1748, 1999, 2052, 3239, 3332, 3587, 3816, 3854, 3934, 4405, 4436], '(6296)': [337], 'Google': [338, 362, 373, 393, 430, 445, 456, 520, 534, 549, 574, 603, 623, 674, 699, 719, 739, 767, 812, 831, 916, 933, 955, 974, 998, 1030, 1074, 1116, 1207, 1236, 1263, 1289, 1340, 1407, 1431, 1455, 1576, 1603, 1640, 1669, 1713, 1750, 2001, 2054, 3241, 3334, 3589, 3818, 3856, 3936, 4407, 4438], 'Scholar).': [339, 394, 457, 624, 768, 832, 1031, 1075, 1117, 1290, 1341, 1456, 1670, 1714, 1751, 2002, 3242, 3335, 3590, 3819, 3857, 3937, 4439], 'controlled': [344], 'regulated': [346], 'by': [347, 498, 1127, 1320, 1467, 2080, 2139, 2184, 2657, 2724, 2767, 2899, 2964, 3008, 3035, 3039, 3097, 3127, 3172, 3246, 3360, 3415, 3424, 3430, 3470, 3485, 3638, 3999, 4080, 4174, 4180, 4254, 4340], 'proteins': [352, 490, 778, 785, 877, 1156, 1359, 1458, 1507, 1523, 1542, 2669, 2787, 3608, 3712, 3870, 4008], '(2Yang': [353], 'E.': [354, 560, 581, 798, 903, 1268, 3229], 'Korsmeyer': [355, 508, 524, 540, 588, 729, 751, 1439, 1654, 1737], 'S.J.': [356, 509, 525, 541, 589, 730, 752, 1440, 1738], 'Blood.': [357], '1996;': [358, 708, 733, 1401], '88:': [359], '386-401Crossref': [360], 'Scholar,': [363, 374, 431, 446, 521, 535, 550, 575, 604, 675, 700, 720, 740, 813, 917, 934, 956, 975, 999, 1208, 1237, 1264, 1408, 1432, 1577, 1604, 1641, 4408], '3Green': [364], 'D.R.': [365, 907, 1064, 1274], 'Reed': [366, 824, 1248, 1588, 3578, 4427], 'J.C.': [367, 448, 825, 1056, 1249, 3579, 4428], 'Science.': [368, 1633, 4431], '1998;': [369, 382, 663, 910, 927, 1201, 1230, 1257, 3583, 3807, 4432], '281:': [370, 4433], '1309-1312Crossref': [371], '4Kelekar': [375], 'A.': [376, 596, 657, 938, 942, 1214, 1224, 1256, 1596, 1620, 1645, 1662, 3312, 3571], 'Thompson': [377, 586, 658, 1392, 1567], 'C.B.': [378, 587, 659, 1393, 1568], 'Trends': [379, 660], 'Cell': [380, 566, 661, 804, 924, 965, 1066, 1228, 1742, 2045, 3326], 'Biol.': [381, 435, 567, 610, 662, 706, 754, 805, 1067, 1229, 1276, 1743, 3327, 3805], '8:': [383, 664], '324-330Abstract': [384, 665], 'Full': [385, 387, 439, 441, 514, 615, 617, 666, 668, 711, 713, 759, 761, 990, 992, 1022, 1024, 1108, 1110, 1281, 1283, 1332, 1334, 1423, 1425, 1447, 1449, 3810, 3812], 'Text': [386, 388, 440, 442, 515, 616, 618, 667, 669, 712, 714, 760, 762, 991, 993, 1023, 1025, 1109, 1111, 1282, 1284, 1333, 1335, 1424, 1426, 1448, 1450, 3811, 3813], 'PDF': [389, 443, 516, 619, 670, 715, 763, 994, 1026, 1112, 1285, 1336, 1427, 1451, 3814], '(539)': [392, 673], 'This': [395, 1487, 2260, 3974, 4042], 'can': [398], 'divided': [400], 'antiapoptotic': [402, 1367], '(Bcl-2,': [403], 'Bcl-XL,': [404, 841, 3723, 4460], 'Bcl-w,': [405], 'Mcl-1,': [406], 'A1)': [407], '(Bax,': [410], 'Bak,': [411, 640, 842, 3722, 4459, 4557], 'Bok/Mtd,': [412], 'Bcl-Xs,': [413], 'Bid,': [414], 'Bad,': [415], 'Bik/Nbk,': [416], 'Bim,': [417], 'Blk)': [418], 'members': [419, 468, 835, 1147, 3799], '(5Kroemer': [420], 'G.': [421, 689, 750, 964, 1222, 1418, 1624, 1653, 3227, 4430], 'Nat.': [422, 526, 1065, 1741], 'Med.': [423], '1997;': [424, 436, 450, 528, 612, 756, 1105, 1570, 1597, 1634, 1663, 2048], '3:': [425], '614-620Crossref': [426], '(1717)': [429], '6Jacobson': [432], 'M.D.': [433], 'Curr.': [434], '7:': [437], 'R277-R281Abstract': [438], '7Reed': [447], '387:': [451], '773-776Crossref': [452], '(1391)': [455], 'Although': [458, 3520], 'overall': [460, 1351], 'amino': [461], 'acid': [462, 2019], 'sequence': [463], 'homology': [464, 481], 'between': [465, 2853, 3743, 3883, 4121, 4507, 4530, 4560], 'relatively': [470], 'low,': [471], 'they': [472], 'contain': [473, 1459], 'highly': [474], 'conserved': [475, 626], 'domains,': [476], 'referred': [477], 'domains': [482, 628], '(BH1': [483], '-4).': [485], 'activity': [487, 1549], 'these': [489, 632, 4447], 'regulated,': [494], 'at': [495, 847, 863, 2141, 2205, 2235, 2253, 2266, 2293, 2364, 2375, 2381, 2399, 2443, 2456, 2494, 2554, 2596, 2616, 2642, 2729, 2745, 2820, 2951, 3001, 3028, 3062, 3069, 3090, 3120, 3188, 3210, 3285, 3294, 3352, 3404, 3448, 3683, 3782, 4135, 4282], 'least': [496, 864], 'partly,': [497], 'formation': [499, 648, 1120, 1802], 'homo-': [501], 'heterocomplexes': [503], '(8Oltvai': [504], 'Z.N.': [505, 539, 579], 'Milliman': [506, 727, 1437], 'C.L.': [507, 728, 1438], 'Cell.': [510, 986, 1018, 1104, 1328, 1419, 1443], '1993;': [511, 828], '74:': [512], '609-619Abstract': [513], '(5878)': [519], '9Knudson': [522], 'C.M.': [523], 'Genet.': [527], '16:': [529], '358-363Crossref': [530], '(350)': [533], '10Yin': [536], 'X.-M.': [537, 1647], 'Oltvai': [538, 578], '1994;': [543, 568, 806, 1995], '369:': [544], '321-323Crossref': [545], '(1221)': [548], '11Borner': [551], 'C.': [552, 556, 679, 790, 794, 936, 977, 1199, 1218, 4412], 'Martinou': [553, 561, 791, 799, 1225, 1615, 1631, 1703, 2043, 3323, 3846, 3926], 'I.': [554, 792, 1095, 1195, 1616, 2040, 4410], 'Mattmann': [555, 793], 'Irmler': [557, 795], 'M.': [558, 796, 921, 979, 1005, 1099, 1191, 1323, 1379, 1566, 1587, 1651, 1736, 1989, 4397], 'Schaerer': [559, 797], 'J.-C.': [562, 800, 1226, 1622, 1632, 1704, 2044, 3847, 3927], 'Tschopp': [563, 801], 'J.': [564, 565, 609, 693, 705, 742, 748, 753, 802, 803, 909, 962, 1007, 1227, 1275, 1416, 1589, 1706, 3325, 3804, 3849, 3929], '126:': [569, 807], '1059-1068Crossref': [570, 808], '(175)': [573, 811], '12Sedlak': [576], 'T.W.': [577], 'Yang': [580], 'Wang': [582, 984, 1102], 'K.': [583, 722, 746, 1626, 1649, 3320], 'Boise': [584], 'L.H.': [585], 'Proc.': [590, 1250, 1590, 1656], 'Natl.': [591, 1251, 1591, 1657], 'Acad.': [592, 1252, 1592, 1658], 'Sci.': [593, 1253, 1593, 1659], 'U.': [594, 1254, 1594, 1660], 'S.': [595, 815, 817, 819, 944, 1193, 1216, 1255, 1585, 1595, 1612, 1614, 1661, 1698, 1700, 2038, 3225, 3308, 3316, 3318, 3841, 3843, 3921, 3923, 4395, 4426], '1995;': [597, 694], '92:': [598], '7834-7838Crossref': [599], '(784)': [602], '13Hsu': [605], 'Y.-T.': [606, 3801], 'Youle': [607, 1324, 3802], 'R.J.': [608, 691, 1015, 1325, 3803], 'Chem.': [611, 707, 755, 1277, 3806], '272:': [613, 757], '13829-13834Abstract': [614], '(514)': [622], 'BH': [627], 'involved': [630], 'interactions.': [633], 'proteins,': [637, 1473, 2565, 2609, 4448], 'BH3': [642, 1372], 'domain': [643, 772, 1488], 'essential': [645], 'complex': [647, 1083, 1119], 'well': [650], 'their': [653, 3659, 3665], '"killing"': [654], 'effect': [655, 3913], '(4Kelekar': [656], '14Chittenden': [676], 'T.': [677, 940, 1185, 1991], 'Flemington': [678], 'Houghton': [680], 'A.B.': [681], 'Ebb': [682], 'R.G.': [683], 'Gallo': [684], 'G.J.': [685], 'Elangovan': [686], 'B.': [687, 919, 946, 1197, 1212, 1606, 1696, 3231, 3322, 3839, 3919], 'Chinnadurai': [688], 'Lutz': [690], 'EMBO': [692, 908], '14:': [695], '733-736Crossref': [696], '(438)': [698], '15Hunter': [701], 'J.J.': [702, 1410], 'Parslow': [703], 'T.G.': [704, 1272], '271:': [709], '8521-8524Abstract': [710], '(107)': [718], '16Wang': [721], 'Yin': [723, 1646], 'X.M.': [724], 'Chao': [725], 'D.T.': [726], 'Genes': [731], 'Dev.': [732], '10:': [734], '2859-2869Crossref': [735], '(808)': [738], '17Zha': [741], 'Harada': [743], 'H.': [744, 1381, 1412, 1560], 'Osipov': [745], 'Jockel': [747], 'Waksman': [749, 1652], '24101-24104Abstract': [758], '(267)': [766], 'hydrophobic': [770, 1461, 1485, 1497], 'C-terminal': [771, 1484], 'some': [775, 865], 'implicated': [781], 'targeting': [783], 'intracellular': [787], 'membranes': [788, 1552, 3169], '(11Borner': [789], '18Krajewski': [814], 'Tanaka': [816], 'Takayama': [818], 'Schibler': [820], 'M.J.': [821], 'Fenton': [822], 'W.': [823], 'Cancer': [826], 'Res.': [827], '53:': [829], '4701-4714PubMed': [830], 'Thus,': [833, 4337, 4514], 'many': [834, 876], 'including': [839, 883, 3721], 'Bcl-2,': [840, 1799], 'acting': [846], 'level': [849], 'mitochondria.': [851, 3947, 3995, 4269], 'It': [852], 'now': [853], 'clear': [855], 'that': [856, 1481, 1493, 1524, 1529, 1674, 1794, 2727, 3550, 3553, 3713, 3826, 3901, 3981, 4131, 4150, 4170, 4186], 'have': [858, 893, 1543, 1672, 3454, 3714, 3861, 4391], 'important': [860, 3977], 'function': [861, 1525], 'apoptotic': [866, 3465, 3511, 3534, 3563, 3604, 3674, 3703, 3749, 3886, 3972, 4005, 4232, 4243, 4510], 'signaling': [867], 'cascades': [868], '(3,': [869], '19–': [870], '20).': [871], 'Following': [872], 'stimulus,': [875], 'intramembrane': [881, 1160], 'space,': [882], 'c,': [885], 'adenylate': [886], 'kinase,': [887], 'Smac/DIABLO,': [888], 'procaspases,': [889], 'apoptosis-inducing': [891], 'factor,': [892], 'reported': [895, 3789, 3825, 4362, 4393], 'released': [898], '(21Bossy-Wetzel': [902], 'Newmeyer': [904], 'D.D.': [905], 'Green': [906, 1063, 1273], '17:': [911, 3584], '37-49Crossref': [912], '(1107)': [915], '22Single': [918], 'Leist': [920], 'Nicotera': [922], 'P.': [923, 1060, 1091, 1556], 'Death': [925, 966, 2046], 'Diff.': [926, 967], '5:': [928], '1001-1003Crossref': [929], '(97)': [932, 954], '23Kohler': [935], 'Gahm': [937], 'Noma': [939], 'Nakazawa': [941], 'Orrenius': [943], 'Zhivotovsky': [945], 'FEBS': [947], 'letter.': [948], '1999;': [949, 968, 1278, 1420, 1444, 3235, 3328, 4401], '447:': [950], '10-12Crossref': [951], '24Lorenzo': [957], 'H.K.': [958], 'Susin': [959, 4417], 'S.A.': [960, 4418], 'Penninger': [961], 'Kroemer': [963, 4429], '6:': [969], '516-524Crossref': [970], '(426)': [973], '25Du': [976], 'Fang': [978], 'Li': [980, 982, 1411], 'Y.': [981, 3575, 4399], 'L.': [983, 1189, 1245, 1618], 'X.': [985, 1103], '102:': [988, 1020], '33-42Abstract': [989], '(2941)': [997], '26Verhagen': [1000], 'A.M.': [1001, 1610], 'Ekert': [1002], 'P.G.': [1003], 'Pakusch': [1004], 'Silke': [1006], 'Connolly': [1008], 'L.M.': [1009], 'Reid': [1010], 'G.E.': [1011], 'Moritz': [1012], 'R.L.': [1013], 'Simpson': [1014], 'Vaux': [1016], 'D.L.': [1017], '43-53Abstract': [1021], '(1985)': [1029], 'release': [1033, 1154, 1180, 1691, 1729], 'c': [1036, 1050, 1080, 1183, 1732], 'fast': [1043], 'process,': [1044], 'depleting': [1045], 'within': [1051], 'few': [1053], 'minutes': [1054], '(27Goldstein': [1055], 'Waterhouse': [1057, 1269], 'N.J.': [1058, 1270], 'Juin': [1059], 'Evan': [1061], 'G.I.': [1062], '2:': [1069, 1745], '156-162Crossref': [1070], '(886)': [1073], 'cytosol,': [1078], 'forms': [1081, 1489, 1769, 4496], 'Apaf-1,': [1085], 'dATP,': [1086], 'procaspase': [1088], '9': [1089, 1124], '(28Li': [1090], 'Nijhawan': [1092], 'D.': [1093, 1247, 1389, 1436, 1442], 'Budihardjo': [1094], 'Srinivasula': [1096], 'S.M.': [1097], 'Ahmad': [1098], 'Alnemri': [1100], 'E.S.': [1101], '91:': [1106], '479-489Abstract': [1107], '(6261)': [1115], 'leads': [1121], 'caspase': [1123, 2437, 2923, 3372, 3392, 3422, 4310], 'activation': [1125, 1129], 'followed': [1126], 'downstream': [1128], 'other': [1131, 1144, 1356, 1539, 3709, 3796, 3869, 4366], 'caspases,': [1132], 'ultimately': [1133], 'leading': [1134], 'cell': [1136, 2031, 2277, 3676], 'death.': [1137], 'Mounting': [1138], 'evidence': [1139], 'points': [1140], 'central': [1150, 1460], 'regulators': [1151], 'space.': [1161], 'Overexpression': [1162], 'addition': [1169, 2867, 3010, 4350], 'purified': [1171, 3220, 3267, 3303, 3337, 4200], 'recombinant': [1172, 1681, 2020], 'directly': [1174], 'isolated': [1176, 1693, 2898, 2906, 3998, 4173, 4304], 'triggers': [1178, 1297], '(29Rosse': [1184], 'Olivier': [1186], 'R.': [1187, 1210, 1220, 1630, 1702, 2042, 3314, 3845, 3925], 'Monney': [1188], 'Rager': [1190], 'Conus': [1192], 'Fellay': [1194], 'Jansen': [1196], 'Borner': [1198], '391:': [1202], '496-499Crossref': [1203], '(799)': [1206], '30Eskes': [1209], 'Antonsson': [1211, 3230, 3321], 'Osen-Sand': [1213, 3309], 'Montessuit': [1215, 1611, 1697, 3315, 3840, 3920], 'Richter': [1217], 'Sadoul': [1219, 1629, 2041], 'Mazzei': [1221, 1623, 3226], 'Nichols': [1223, 3311], '143:': [1231], '217-224Crossref': [1232], '(586)': [1235], '31Jurgensmeier': [1238], 'J.M.': [1239, 1434, 4416], 'Xie': [1240, 1580, 4423], 'Z.': [1241, 1581, 4424], 'Deveraux': [1242], 'Q.': [1243], 'Ellerby': [1244], 'Bredesen': [1246], '95:': [1258], '4997-5002Crossref': [1259], '(1375)': [1262], '32Finucane': [1265], 'D.M.': [1266], 'Bossy-Wetzel': [1267], 'Cotter': [1271], '274:': [1279], '2225-2233Abstract': [1280], '(653)': [1288], 'However,': [1291, 3753, 4501], 'mechanism': [1293], 'permeability': [1299, 4388], 'unclear.': [1306], 'three-dimensional': [1308], 'solution': [1309], 'structure': [1310, 1344, 1476, 3461, 3595, 3882, 3917], 'full-length': [1313], 'recently': [1317], 'solved': [1319], 'NMR': [1321], '(33Suzuki': [1322], 'Tjandra': [1326], 'N.': [1327, 4414], '103:': [1330], '645-654Abstract': [1331], '(909)': [1339], 'shows': [1345], 'high': [1347, 3731], 'similarity': [1348], 'conformation': [1352], 'information': [1363], 'available,': [1365], 'Bcl-XL': [1369, 4538], 'domain-only': [1373], 'Bid': [1375, 2439, 2925, 3289, 3338, 3357, 3365, 3410, 3418, 4312], '(34Muchmore': [1376], 'S.W.': [1377, 1399, 1562, 1564], 'Sattler': [1378], 'Liang': [1380, 1559], 'Meadows': [1382], 'R.P.': [1383], 'Harlan': [1384], 'J.E.': [1385], 'Yoon': [1386], 'H.S.': [1387], 'Nettesheim': [1388], 'Chang': [1390], 'B.S.': [1391], 'Wong': [1394], 'S.-L.': [1395], 'Ng': [1396], 'S.-C.': [1397], 'Fesik': [1398, 1563], '381:': [1402], '335-341Crossref': [1403], '(1289)': [1406], '35Chou': [1409], 'Salvesen': [1413], 'G.S.': [1414], 'Yuan': [1415], 'Wagner': [1417], '96:': [1421, 1445], '615-624Abstract': [1422], '(422)': [1430], '36McDonnell': [1433], 'Fushman': [1435], 'Cowburn': [1441], '625-634Abstract': [1446], '(337)': [1454], 'helices': [1462], '(α5': [1463], 'α6)': [1465], 'surrounded': [1466], 'amphipathic': [1468], 'helices.': [1469], 'Of': [1470], 'three': [1472, 2841, 4341], 'only': [1479, 3988], 'one': [1480], 'contains': [1482, 2563, 2605], 'domain.': [1486], 'helix': [1491], '(α9)': [1492], 'protects': [1494], 'BH3-containing': [1496], 'cleft': [1498], 'protein.': [1501], 'structures': [1503], 'reminiscent': [1509], 'diphtheria': [1511], 'toxin': [1512], 'colicins': [1515], 'A': [1516, 2705, 2711, 2732, 3310, 4479], 'E1.': [1518], 'These': [1519], 'toxins': [1520], 'pore-forming': [1522], 'channels': [1528, 1685], 'allow': [1530, 1727], 'passage': [1531, 2185], 'ions': [1533], 'small': [1535, 3522], 'polypeptides.': [1536], 'possess': [1547], 'channel-forming': [1548], 'artificial': [1551], '(37Minn': [1553], 'A.J.': [1554], 'Velez': [1555], 'Schendoe': [1557], 'S.L.': [1558, 1579, 1655], 'Muchmore': [1561], 'Fill': [1565], '385:': [1571], '353-357Crossref': [1572], '(723)': [1575], '38Schendel': [1578], 'Montal': [1582, 1586], 'Matsuyama': [1584, 4425], '94:': [1598, 1664], '5113-5118Crossref': [1599], '(548)': [1602], '39Antonsson': [1605], 'Conti': [1607], 'F.': [1608, 1628], 'Ciavatta': [1609], 'Lewis': [1613], 'Bernasconi': [1617], 'Bernard': [1619], 'Mermod': [1621], 'Maundrell': [1625, 3319], 'Gambale': [1627], '277:': [1635], '370-372Crossref': [1636], '(932)': [1639], '40Schlesinger': [1642], 'P.H.': [1643, 1740], 'Gross': [1644], 'Yamamoto': [1648], 'Saito': [1650], '11357-11362Crossref': [1665], '(443)': [1668], 'We': [1671], 'contrast': [1676, 3903], 'oligomeric': [1678, 4221], 'Bax,': [1679, 3720, 4062], 'monomeric': [1680, 1849, 2021, 3836, 4061, 4114, 4235], 'cannot': [1683], 'form': [1684, 1721, 1773], 'liposomes': [1687, 1734], 'nor': [1688, 3702], 'cytochromec': [1690], '(41Antonsson': [1695, 3838, 3918], 'Lauper': [1699, 3317, 3842, 3922], 'Eskes': [1701, 3313, 3844, 3924], 'Biochem.': [1705, 3848, 3928], '345:': [1708, 3851, 3931], '271-278Crossref': [1709, 3852, 3932], '(563)': [1712, 3855, 3935], 'Recently,': [1715], 'tetramers': [1717], 'were': [1718, 1829, 1865, 1877, 1888, 1896, 1905, 1918, 1924, 1935, 1947, 1959, 1969, 2056, 2096, 2110, 2129, 2182, 2233, 2318, 2379, 2396, 2432, 2465, 2511, 2614, 2652, 2758, 2765, 2772, 2788, 2802, 2827, 2836, 2880, 2893, 2897, 2962, 2985, 3033, 3111, 3151, 3165, 3186, 3609, 3625, 3636, 3983, 3997, 4009, 4025, 4103, 4142, 4190, 4294, 4456, 4471], 'enough': [1725], '(42Saito': [1735], 'Schlesinger': [1739], '553-555Crossref': [1746], '(411)': [1749], 'Here': [1752], 'we': [1753, 1792, 3824, 3939, 3982, 4302], 'show': [1754, 1793], 'that,': [1755], 'cultured': [1757, 2057, 2104, 2111, 2881], 'exposed': [1759], 'oligomers,': [1770], 'possibly': [1772, 3565, 3868], 'complexes': [1774, 3734], 'yet': [1776], 'unidentified': [1777], 'proteins.': [1780, 4369], 'oligomers': [1783, 4088, 4189, 4281, 4326, 4445, 4498, 4518, 4535], 'found': [1785, 3498, 3698, 4226], 'inserted': [1786], 'Moreover,': [1791], 'presence': [1797, 3476], 'oligomer': [1801], 'inhibited.': [1810], 'Superdex': [1812, 2621], '200': [1813, 2622, 3362, 3369], '(16/60)': [1814, 2623], 'column': [1815, 2624, 2662, 2721, 3635, 3780, 4455], 'was': [1816, 1851, 1859, 1980, 2078, 2195, 2214, 2219, 2226, 2250, 2262, 2287, 2308, 2362, 2454, 2474, 2522, 2552, 2566, 2570, 2580, 2610, 2655, 2663, 2722, 2735, 2743, 2813, 2852, 2860, 2918, 2996, 3006, 3067, 3079, 3095, 3125, 3143, 3214, 3244, 3260, 3269, 3298, 3339, 3358, 3399, 3411, 3419, 3468, 3497, 3530, 3697, 3741, 3781, 3829, 3954, 4154, 4177, 4198, 4225, 4239, 4482, 4512, 4539], 'Amersham': [1818, 2671, 2809], 'Pharmacia': [1819, 2672, 2810], 'Biotech,': [1820], '14%': [1822, 2775], 'polyacrylamide': [1823, 2005], 'gels': [1824, 1828, 3156], '10%': [1826, 2064, 3154, 3384], 'NuPage': [1827, 3155], 'Novex': [1831], '(San': [1832], 'Diego,': [1833], 'CA).': [1834], 'CHAPS': [1835, 2480, 2569, 2654, 3910, 3942, 3953, 4013], '1The': [1836], 'abbreviations': [1837], 'used': [1838, 3456], 'are:CHAPS3-[(3-cholamidopropyl)dimethylammonio]-1-propane': [1839], 'sulfonatePAGEpolyacrylamide': [1840], 'electrophoresisDTTdithiothreitolVDACvoltage-dependent': [1842], 'channelANTadenosine': [1844], 'translocatorMBmitochondrial': [1846], 'bufferHAhemagglutininMops4-morpholinepropanesulfonic': [1847], 'acidrBaxrecombinant': [1848], 'Roche': [1853], 'Molecular': [1854, 1949, 2180, 2847], 'Biochemicals,': [1855], 'Triton': [1857, 2483, 2650, 2659, 3254, 3259, 3613, 3785, 3827, 3859, 3905, 3959], 'X-100': [1858, 3614, 3786, 3828, 3906, 3960], 'Fluka.': [1861], 'Polyclonal': [1862], 'anti-Bax': [1863, 1875, 3643, 4147], 'antibodies': [1864, 1876, 1887, 1895, 1904, 1917, 1923, 1934, 1946, 1958, 1968, 2793, 4165], 'purchased': [1866], 'Upstate': [1868], 'Biotechnology,': [1869, 1939], 'Inc.': [1870, 1940, 1951], '(Lake': [1871], 'Placid,': [1872], 'NY),': [1873], 'monoclonal': [1874, 1885, 1902, 1912, 1921, 1929, 1944, 1954, 1964, 4146], 'R': [1879], '&': [1880], 'D': [1881], 'Systems': [1882], '(Minneapolis,': [1883], 'MN),': [1884], 'anti-Bcl-2': [1886], 'Genosys': [1890], '(Cambridge,': [1891], 'UK),': [1892], 'polyclonal': [1893, 1915, 1932, 1976], 'anti-Bcl-XL': [1894], 'Transduction': [1898], 'Laboratories': [1899], '(Lexington,': [1900], 'KY),': [1901], 'anti-Bak': [1903], 'Oncogene': [1907], 'Research': [1908], 'Products': [1909], '(Boston,': [1910], 'MA),': [1911], 'anti-VDAC': [1913], 'anti-catalase': [1916], 'Calbiochem,': [1920], 'anti-HA': [1922], 'Babco': [1926], '(Richmond,': [1927], 'CA),': [1928, 1943], 'anti-Myc': [1930], 'anti-His': [1933, 3103], 'Santa': [1937], 'Cruz': [1938], '(Santa': [1941], 'Cruz,': [1942], 'anti-COX': [1945], 'Probes,': [1950], '(Eugene,': [1952], 'OR),': [1953], 'anti-Golgi': [1955], '58-kDa': [1956], 'Sigma,': [1961], 'anti-calnexin': [1965], 'anti-Hsp70': [1967], 'Affinity': [1971], 'Bioreagents': [1972], '(Golden,': [1973], 'CO).': [1974], 'rabbit': [1977], 'anti-ANT': [1978], 'antibody': [1979, 3104], 'kind': [1982], 'gift': [1983], 'Prof.': [1985], 'Theo': [1986], 'Wallimann': [1987, 1990], '(43Rojo': [1988], 'Biochim.': [1992], 'Biophys.': [1993], 'Acta.': [1994], '1187:': [1996], '360-367Crossref': [1997], '(14)': [2000], '3-[(3-cholamidopropyl)dimethylammonio]-1-propane': [2003], 'sulfonate': [2004], 'electrophoresis': [2007], 'dithiothreitol': [2008], 'buffer': [2016, 2153, 2412, 2928, 3044, 3161, 3251, 3374], 'hemagglutinin': [2017], '4-morpholinepropanesulfonic': [2018], 'HEK': [2023, 2834, 2909], 'stable': [2029], 'line': [2032], 'constitutively': [2033], 'overexpressing': [2034], '(HeLa-Bcl-2)': [2036], '(44Estoppey': [2037], 'Rodriguez': [2039], 'Differ.': [2047], '4:': [2049], '34-38Crossref': [2050], '(34)': [2053], 'Scholar)': [2055], 'RPMI': [2059], '1640': [2060], 'medium': [2061, 2085], 'supplemented': [2062, 2173], 'fetal': [2065], 'calf': [2066], 'serum,': [2067], '2': [2068, 2373, 2756, 2991, 3402], 'mml-glutamine,': [2069], '50': [2070, 2074, 2435, 2854, 3082, 3106, 4308], 'μg/ml': [2071], 'streptomycin,': [2072], 'IU/ml': [2075], 'penicillin.': [2076], 'induced': [2079, 3245, 3469, 3862, 4079, 4262], 'culturing': [2081, 3471], 'containing': [2086, 2134, 2478, 2584, 2973, 3252], '1': [2087, 2135, 2160, 2338, 2355, 2408, 2489, 2558, 2591, 2647, 2921, 2974, 3389, 3478], 'μm': [2088, 2858, 2922, 3479], '16': [2091, 2106, 2883, 3118, 3482], 'h;': [2092], 'alternatively,': [2093], 'irradiated': [2098], '(280': [2099], 'mJ': [2100], 'cm−2)': [2101], 'subsequently': [2103, 2203, 2251], 'h.': [2107, 2559, 2884], 'Control': [2108], 'absence': [2114], 'without': [2118], 'irradiation.': [2120, 3487], 'At': [2121, 2446, 2544, 2885, 2954], 'end': [2123, 2448, 2546, 2887, 2956], 'treatment,': [2126, 4082], 'harvested': [2130], 'phosphate-buffered': [2132], 'saline': [2133], 'mm': [2136, 2158, 2161, 2164, 2336, 2339, 2353, 2356, 2414, 2417, 2420, 2425, 2428, 2628, 2631, 2930, 2933, 2938, 2941, 2944, 2975, 3021, 3046, 3049, 3273, 3276, 3343, 3346, 3376, 3379, 3382, 3432, 3437, 3440], 'EDTA,': [2137, 2162, 2340, 2357], 'recovered': [2138, 2380, 2963, 3034, 3126], 'centrifugation': [2140, 2901, 2965, 3036, 3128, 4001, 4176], '750': [2142], '×': [2143, 2190, 2207, 2237, 2255, 2268, 2295, 2304, 2496, 2556, 3071, 3190], 'g': [2144, 2208, 2238, 2256, 2269, 2296, 2305, 2497, 3072, 3191], '10': [2146, 2163, 2258, 2298, 2335, 2352, 2460, 3074, 3378], 'min,': [2147, 2461, 3075], 'washed,': [2148], 'suspended': [2150, 2170, 2288, 2309, 2406, 2475, 2523, 2581, 3144], '(MB)': [2154], '(210': [2155], 'mmmanitol,': [2156], '70': [2157], 'sucrose,': [2159, 2334, 2351, 3385], 'Hepes-NaOH,': [2165, 2337, 2354, 2415, 2629, 2931, 3274, 3377], 'pH': [2166, 2341, 2358, 2430, 2527, 2638, 2946, 3013, 3283, 3350, 3386, 3444], '7.5).': [2167], 'MB': [2172, 2290, 2468, 2477, 2583, 2972], 'complete': [2175], 'protease': [2176], 'inhibitor': [2177], 'mixture': [2178], '(Roche': [2179, 2846], 'Biochemicals)': [2181], 'disrupted': [2183], '25G1': [2188], '0.5': [2189, 2424, 2913, 2940], '25': [2191, 2627, 3272, 3342, 3436], 'needle.': [2192], 'sample': [2194, 2361, 2453, 2551, 2734, 2995, 3066, 3146, 3398], 'passed': [2196], 'needle': [2199], 'five': [2200], 'times': [2201, 3132], 'centrifuged': [2204, 2234, 2252, 2265, 2363, 2455, 2493, 2553, 2595, 3068, 3187], '2000': [2206, 2236], '3': [2210, 2240, 2535, 3088], 'min.': [2211, 2259, 2299, 2500, 2543, 2601, 4315], 'supernatant': [2213, 2249, 2261, 2502, 3078], 'saved,': [2215, 2567], 'pellet': [2218, 2280, 2307, 2521, 2579], 'resuspended': [2220, 2967], 'MB.': [2222, 2393], 'breakage': [2224], 'procedure': [2225], 'repeated': [2227], 'four': [2228, 3131, 3176], 'times.': [2229], 'combined': [2231], 'supernatants': [2232], 'min': [2241, 2272, 2442, 2750, 2863, 2950, 3000, 3027, 3061, 3194], 'remove': [2243], 'nuclei': [2244], 'unbroken': [2246], 'cells.': [2247, 3466, 3887, 3973], '13,000': [2254, 2294, 2303, 2457], 'kept': [2263], '100,000': [2267, 2495, 2555, 2597, 3189], '30': [2271, 2441, 2444, 2499, 2600, 2952, 2999, 3060, 4314], 'give': [2274], 'cytosolic': [2276, 3544, 3551], 'fraction.': [2278, 2508], 'fraction,': [2281, 2286], 'corresponding': [2282, 2911, 3686], 'recentrifuged': [2292], 'Alternatively,': [2300], 'first': [2302], '4': [2311, 2376, 2400, 2419, 2617, 2935, 3063, 3091, 3100, 3121], 'ml': [2312, 2330, 2347, 2409, 2757], 'MB,': [2314], '2-ml': [2316], 'portions': [2317], 'layered': [2319], 'top': [2321, 2344], 'discontinuous': [2324], 'sucrose': [2325, 2389, 4203, 4215], 'gradient': [2326], 'consisting': [2327], '20': [2329, 2542, 2749, 3020, 3405], '1.2': [2332, 2385], 'm': [2333, 2350, 2388], '7.5,': [2342, 2639, 3284, 3351], '17': [2346], '1.6': [2349, 2387, 2869], '7.5.': [2359], '27,000': [2365], 'rpm': [2366], 'Beckman': [2369], 'SW28': [2370], 'rotor': [2371], 'h': [2374, 3089, 3119, 3403, 3483], '°C.': [2377, 2401, 2445, 2953, 3064, 3092, 3122, 3287, 3354, 3406, 3450], 'Mitochondria': [2378, 2905, 3996], 'interface': [2383], 'washed': [2391, 2466, 2471, 3130, 3141], 'All': [2394], 'manipulations': [2395], 'carried': [2397], 'out': [2398], 'Isolated': [2402], '(3': [2404, 3394], 'mg/ml)': [2405, 3367], 'KCl': [2411, 2927], '(15': [2413, 2929], '125': [2416, 2932], 'KCl,': [2418, 2934], 'MgCl2,': [2421], '5': [2422, 2427, 2937, 2943, 3193], 'mmNaH2PO4,': [2423], 'EGTA,': [2426, 2942], 'succinate,': [2429, 2945], '7.5)': [2431, 2947, 3387], 'incubated': [2433, 2485, 2538, 2587, 2919, 2997, 3114, 3400], 'nmrecombinant': [2436], '8-cleaved': [2438, 2924, 3356, 4311], 'incubation,': [2451, 2549, 2890, 2959], '×g': [2458, 2598], 'buffer.': [2469, 3139], 'fraction': [2473, 3783, 4197], '2%': [2479, 2482, 2585, 2635, 2658, 3612, 3958, 4012], 'X-100,': [2484], 'ice': [2487, 2540, 2589], 'h,': [2490, 2592], 'sonicated,': [2491, 2593], 'corresponds': [2503, 4043], 'solubilized': [2506, 2606, 3038], 'Protein': [2509, 3093, 3123, 3232], 'concentrations': [2510, 2989], 'determined': [2512, 2723], 'using': [2513], 'Bio-Rad': [2515], 'assay': [2517], 'kit.': [2518], '0.1': [2525, 3345, 3439], 'mNa2CO3,': [2526], '12,': [2528], 'final': [2531, 2574, 2988, 3017], 'concentration': [2533, 2575, 3018, 3546], 'mg/ml': [2536], 'gfor': [2557], 'supernatant,': [2561, 2603], 'nonmembrane-integrated': [2564], 'added': [2571, 2861, 2986, 3112], '2%.': [2577], 'CHAPS,': [2586, 2637], 'integral': [2607], 'saved.': [2611], 'Gel': [2612, 3645], 'filtrations': [2613], 'performed': [2615], '°C': [2618], 'equilibrated': [2625], '300': [2630], 'NaCl,': [2632, 3050, 3383], '0.2': [2633, 3275], 'mmDTT,': [2634], '(w/v)': [2636], 'run': [2641], 'flow': [2644], 'rate': [2645], 'ml/min.': [2648], 'When': [2649], 'extracts': [2651, 3624, 3745, 4024, 4247], 'analyzed,': [2653], 'replaced': [2656], 'X-100.': [2660, 3255], 'calibrated': [2664], 'filtration': [2667, 3646, 4298, 4454], 'standard': [2668], 'Biotech': [2673], 'giving': [2674], 'following': [2676], 'elution': [2677, 2751], 'volumes:': [2678], 'thyroglobulin': [2679], '(669,000': [2680], 'Da),': [2681, 2686, 2691, 2696, 2701, 2707, 2713], '49.9': [2682], 'ml;': [2683, 2688, 2693, 2698, 2703, 2709], 'ferritin': [2684], '(440,000': [2685], '55.9': [2687], 'catalase': [2689], '(232,000': [2690], '65.5': [2692], 'BSA': [2694], '(67,000': [2695], '77.5': [2697], 'ovalbumin': [2699], '(43,000': [2700], '83.2': [2702], 'chymotrypsinogen': [2704], '(25,000': [2706], '92.9': [2708], 'ribonuclease': [2710], '(13,700': [2712], '97.4': [2714], 'ml.': [2715, 2731], 'void': [2717, 3776], 'volume': [2718, 3777], 'blue': [2725], 'Sepharose': [2726, 3142], 'eluted': [2728, 3678, 3760, 4038, 4084], '43.3': [2730], '500-μl': [2733], 'loaded': [2736], 'onto': [2737], 'column,': [2739], 'eluate': [2742], 'monitored': [2744], '280': [2746], 'nm.': [2747], '(20': [2752], 'ml),': [2753], 'fractions': [2754, 2764, 3632, 3684, 3736, 3766, 3773, 4040, 4090, 4118, 4283, 4289, 4450, 4475, 4553], 'collected,': [2759], 'aliquots': [2761], 'analyzed': [2766, 3152, 3171, 3201, 3626, 3637, 4026, 4457], 'Western': [2768, 3173, 3639, 4160], 'blotting.': [2769], 'samples': [2771, 3150, 3185], 'separated': [2773, 3420], 'SDS-PAGE': [2776], 'under': [2777, 3617, 4016], 'reducing': [2778], 'conditions': [2779], 'transferred': [2781, 3166], 'polyvinylidene': [2783], 'difluoride': [2784], 'membranes.': [2785], 'detected': [2789, 4105, 4153, 4295, 4541], 'specific': [2792], 'indicated': [2795], 'figures,': [2798], 'blots': [2801], 'developed': [2803], 'ECL': [2806], 'system': [2807, 3162], 'Biotech.': [2811], 'tagged': [2814], 'His,': [2816], 'HA,': [2817], 'Myc': [2819], 'N': [2822, 3212, 3296], 'terminus,': [2823], 'constructs': [2826, 2844], 'cloned': [2828], 'pC1': [2831], 'vector': [2832], '(Stratagene).': [2833], 'then': [2837, 3196], 'transfected': [2838, 2908], 'different': [2842, 3177, 4342], '(Fugene6)': [2845], 'Biochemicals).': [2848], 'transfection': [2850], 'efficiency': [2851], '60%.': [2856], '100': [2857, 3381, 3431], 'ZVAD': [2859], '60': [2862], 'prior': [2864], 'μg': [2870, 3101], 'each': [2872], 'plasmids,': [2876], 'harvested,': [2894], 'differential': [2900, 4000, 4175], 'described': [2903, 3223, 3306, 3616, 4015], 'above.': [2904, 3203], 'mg': [2914], 'mmMgCl2,': [2936], 'NaH2PO4,': [2939], '15': [2949, 3026], '400': [2969, 3134], 'μl': [2970, 3083, 3107, 3135, 3363, 3370, 3390], 'EGTA.': [2976], 'cross-linkers': [2978], 'bis-(sulfosuccinimidyl)suberate': [2979], '(Pierce)': [2980, 2984], 'disuccinimidyl': [2982], 'suberate': [2983], 'mm,': [2992], 'room': [3002, 3029], 'temperature.': [3003, 3030], 'reaction': [3005], 'stopped': [3007], 'Tris-HCl,': [3012, 3047, 3344, 3438], '8.0,': [3014], 'subsequent': [3023], 'incubation': [3024, 3040], 'radioimmune': [3042, 3137], 'precipitation': [3043, 3138], '(19': [3045], '140': [3048], '1%': [3051, 3056, 3253, 3263, 3278], 'Nonidet': [3052], 'P-40,': [3053], '0.1%': [3054], 'SDS,': [3055], 'sodium': [3057], 'deoxycholate)': [3058], '12,000': [3070], 'treated': [3080, 3197, 4303], 'G-Sepharose': [3086, 3094, 3110, 3124], 'removed': [3096], 'centrifugation,': [3098], 'rotation': [3116], 'buffer,': [3147], 'Mops': [3159], 'running': [3160], '(Novex).': [3163], 'Proteins': [3164], 'nitrocellulose': [3168], 'blot': [3174, 3640, 4161], 'antibodies,': [3178], 'anti-HA,': [3179], 'anti-Myc,': [3180], 'anti-Bax,': [3181], 'anti-VDAL.': [3183], 'Cytosolic': [3184], 'cross-linker': [3199], 'Full-length': [3204, 3288], 'His': [3208, 3292], 'tag': [3209, 3293], 'terminus': [3213, 3297], 'expressed': [3215, 3299], 'Escherichia': [3217], 'coli': [3218, 3301], 'previously': [3222, 3305], '(45Montessuit': [3224], 'Magnenat': [3228], 'Expression': [3233], 'Purif.': [3234], '15:': [3236], '202-206Crossref': [3237], '(39)': [3240], 'Oligomerization': [3243], 'disrupting': [3247], 'bacteria': [3249], 'During': [3256], 'purification,': [3258], 'exchanged': [3261], 'octyl': [3264, 3279, 3908], 'glucoside.': [3265], 'stored': [3270, 3340, 3447], 'DTT,': [3277, 3347, 3380, 3441], 'glucoside,': [3280, 3909], '30%': [3281, 3348, 3442], 'glycerol,': [3282, 3349, 3443], '−80': [3286, 3353, 3449], 'inE.': [3300], '(46Desagher': [3307], 'J-C.': [3324], '144:': [3329], '891-901Crossref': [3330], '(1093)': [3333], 'Caspase': [3355], 'generated': [3359], 'mixing': [3361], '(12.4': [3366], 'cleavage': [3373], '(50': [3375], '8': [3393, 3423], 'mg/ml),': [3395], 'Over': [3407], '95%': [3408], 'cleaved': [3412], 'estimated': [3414, 4095], 'SDS-PAGE.': [3416], 'Cleaved': [3417], 'binding': [3425], 'Ni2+-nitrilotriacetic': [3427], 'acid-agarose;': [3428], 'step-eluted': [3429], 'imidazole;': [3433], 'dialyzed': [3434], '7.5;': [3445], 'Cultured': [3451], 'study': [3458, 3592], 'quaternary': [3460, 3594, 3666, 3881, 3916], 'Consistent': [3488], 'published': [3490], 'results,': [3491], 'untreated': [3493], '(Fig.': [3508, 3547, 3751, 4182, 4299, 4335], '1).': [3509], 'almost': [3514], 'completely': [3515], 'disappeared': [3516], 'cytosol.': [3519], 'increase': [3523], 'seen': [3531], 'this': [3536, 4205], 'does': [3537], 'fully': [3539], 'account': [3540], 'decreased': [3543], '1),': [3548], 'suggesting': [3549], 'translocated': [3556], 'eliminated': [3561], 'proteolysis': [3567], '(47Wood': [3568], 'D.E.': [3569], 'Thomas': [3570], 'Devi': [3572], 'L.A.': [3573], 'Berman': [3574], 'Beavis': [3576], 'R.C.': [3577], 'Newcomb': [3580], 'E.W.': [3581], 'Oncogene.': [3582], '1069-1078Crossref': [3585], '(308)': [3588], 'To': [3591, 4184, 4440], 'extracted': [3610, 3669, 3871, 4010], '"Materials': [3618, 4017], 'Methods."': [3620], 'soluble': [3622, 3835, 4022], 'filtration,': [3629], 'antibody.': [3644], 'separates': [3647], 'molecules': [3648], 'according': [3649], 'Stokes': [3652], 'radius': [3653], 'gives': [3655], 'estimate': [3657], 'weights': [3661], 'thus': [3663], 'structure.': [3667], 'either': [3671], 'single': [3681], 'peak': [3682, 3764, 3771, 4551], '20–24,': [3685], 'Da': [3693, 4064, 4102], '(Fig.2).': [3694], 'Monomeric': [3695], 'neither': [3699], 'extract.': [3705], 'Furthermore,': [3706, 4301], 'analysis': [3707, 4162], 'suggested': [3716], 'interact': [3718, 4364], 'VDAC,': [3725, 4461], 'all': [3726, 4344], 'coeluted': [3727], '20–24.': [3737], 'Again,': [3738], 'no': [3739, 3912, 4502, 4558], 'difference': [3740, 4503, 4559], 'observed': [3742], '2).': [3752], 'Cox': [3758], 'IV': [3759], 'main': [3763], '28–30': [3767], 'minor': [3770], '22–24.': [3774], '12.': [3784], 'induce': [3791], 'dimerization': [3792], '(48Hsu': [3800], '273:': [3808], '10777-10783Abstract': [3809], '(445)': [3817], 'previous': [3822], 'study,': [3823], 'able': [3830], 'Therefore,': [3858, 3938], 'membrane,': [3875], 'masking': [3876], 'any': [3877], 'differences': [3878], 'Previous': [3888], 'studies': [3889], 'ability': [3892], 'various': [3894, 4167, 4495], 'detergents': [3895], 'showed': [3900, 4169], 'had': [3911, 4077, 4132], 'examined': [3940], 'whether': [3941, 4442], 'could': [3943, 4124], 'extract': [3944, 4033, 4072, 4230, 4273, 4317], 'As': [3948, 4555], 'Fig.': [3951], '3,2%': [3952], 'efficient': [3956], 'extracting': [3962, 3985], 'ensure': [3980, 4185], 'analyzing': [3987], 'subpopulation': [3990], 'Methods,"': [4019], '36–40.': [4041], 'close': [4053], 'theoretical': [4056], 'calculated': [4057], '22,000': [4063], '(Fig.4': [4065, 4109, 4248, 4464], 'A).': [4066, 4110, 4465], 'contrast,': [4068], 'where': [4075], 'mainly': [4085, 4179], '20–28.': [4091], 'Two': [4092, 4466], 'peaks': [4093, 4278, 4468], 'masses': [4097], 'consistently': [4104], '(n': [4106], '=': [4107], '9)': [4108], 'amount': [4112, 4481], 'eluting': [4116, 4473], '36–38': [4119], 'varied': [4120], 'preparations': [4122], 'depend': [4125], 'percentage': [4128], 'entered': [4133], 'time': [4137], 'harvest.': [4139], 'Identical': [4140], 'results': [4141], 'obtained': [4143], 'antibody,': [4148], 'confirming': [4149], 'indeed': [4155], '(results': [4157], 'shown).': [4159], 'marker': [4164], 'organelles': [4168], 'contaminated': [4178], 'ER': [4181], '5).': [4183], 'mitochondria,': [4194], 'further': [4199], 'gradient;': [4204], 'purification': [4206], 'step': [4207], 'improved': [4208], 'purity': [4210], 'preparation.': [4213], 'gradient-purified': [4216], 'confirmed': [4218], 'result;': [4220], '(fractions': [4223, 4237, 4491, 4546], '20–28)': [4224], 'whereas': [4234], '36–40)': [4238], 'B).': [4249], 'addition,': [4251], 'inducing': [4252, 4338], 'exposing': [4255], 'irradiation': [4260], 'also': [4261, 4360, 4483], 'Similar': [4270], 'staurosporine-treated': [4275], '20–22': [4284], '(M': [4285, 4291], 'r': [4286, 4292], '260,000)': [4287], '26–28': [4290], '96,000)': [4293], '6).': [4300, 4336], 'nm': [4309], 'Bid-treated': [4320], 'contained': [4322, 4446], 'same': [4324], 'staurosporine-': [4330], 'UV-treated': [4332], 'stimuli': [4343], 'resulted': [4345], 'oligomerization.': [4348], 'interactions': [4353, 4529], 'members,': [4357], 'Interactions': [4370], 'VDAC': [4377], 'ANT,': [4383], 'part': [4385], 'transition': [4389], 'pore,': [4390], '(49Shimizu': [4394], 'Narita': [4396], 'Tsujimoto': [4398], '399:': [4402], '483-487Crossref': [4403], '(1928)': [4406], '50Marzo': [4409], 'Brenner': [4411], 'Zamzami': [4413], 'Jurgensmeier': [4415], 'Vieira': [4419], 'H.L.A.': [4420], 'Prevost': [4421], 'M.-C.': [4422], '2027-2031Crossref': [4434], '(1058)': [4437], 'investigate': [4441], 'ANT': [4463], 'Bak': [4470, 4531], 'detected,': [4472], '24–26': [4476], '30–32.': [4478], 'low': [4480], 'over': [4485, 4542], 'wide': [4487], 'range': [4490, 4545], '14–32),': [4492], 'suggests': [4494], 'and/or': [4499], 'complexes.': [4500], 'distribution': [4506], 'detected.': [4513], 'since': [4515], 'nonapoptotic': [4527], 'unlikely.': [4537], 'similarly': [4540], '16–32)': [4547], '26–32.': [4554], 'ap': [4563]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994611236', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 8}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 14}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 19}, {'year': 2016, 'cited_by_count': 20}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 23}, {'year': 2012, 'cited_by_count': 44}], 'updated_date': '2024-12-24T15:46:13.092033', 'created_date': '2016-06-24'}