Publication Information

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'abstract_inverted_index': {'Recently': [0, 242], 'we': [1, 243, 1604, 1737, 1869, 4006, 4070, 4117], 'have': [2, 244, 1440, 1564, 1605, 1738, 1807, 3928], 'shown': [3, 245, 1606, 1740, 3930], 'that': [4, 42, 65, 90, 133, 152, 184, 246, 284, 307, 332, 375, 394, 426, 1106, 1198, 1607, 1741, 1793, 1831, 1851, 3931, 4054, 4072, 4119, 4127, 4137], 'the': [5, 110, 116, 149, 158, 208, 211, 224, 247, 352, 358, 391, 400, 450, 453, 466, 491, 496, 569, 572, 624, 630, 634, 661, 664, 668, 678, 700, 705, 890, 1031, 1039, 1058, 1069, 1073, 1127, 1188, 1199, 1204, 1227, 1231, 1235, 1238, 1312, 1435, 1447, 1548, 1556, 1568, 1608, 1627, 1750, 1796, 1801, 1818, 1825, 1858, 1864, 1906, 2029, 2170, 2265, 2327, 2342, 2397, 2413, 2423, 2591, 2614, 2631, 2642, 3026, 3033, 3041, 3326, 3329, 3690, 3695, 3699, 3706, 3888, 3923, 4024, 4045, 4128, 4138], 'metabotropic': [6, 248, 724, 809, 1611], 'glutamate': [7, 249, 725, 810, 1612, 4076, 4088], '5': [8, 250], '(mGlu5)': [9, 251], 'receptor': [10, 85, 171, 252, 327, 413, 726, 811, 1115, 1551], 'can': [11, 27, 154, 213, 253, 269, 396, 455, 1387], 'be': [12, 107, 155, 254, 349, 397, 538, 1185, 1334], 'expressed': [13, 255, 1625, 3737, 3904, 3934, 4007], 'on': [14, 22, 256, 264, 885, 1453, 1567, 1626, 1709, 1863, 2690, 3346, 3935, 3941, 4028], 'nuclear': [15, 29, 45, 49, 81, 91, 99, 163, 174, 190, 227, 257, 271, 287, 291, 323, 333, 341, 405, 416, 432, 469, 511, 552, 573, 631, 665, 679, 692, 887, 1042, 1077, 1134, 1332, 1454, 1569, 1629, 1710, 1752, 1815, 1821, 1866, 1877, 1918, 1928, 2507, 2673, 3703, 3946, 4031, 4064, 4080, 4193], 'membranes': [16, 258, 888, 1455, 1630, 1711, 3937, 3944, 3947, 4032, 4065], 'of': [17, 57, 71, 139, 162, 202, 220, 259, 299, 313, 381, 404, 444, 462, 510, 543, 547, 629, 663, 691, 704, 1033, 1041, 1057, 1130, 1203, 1237, 1397, 1618, 1631, 1635, 1820, 1841, 1860, 1899, 1917, 1922, 2233, 2269, 2344, 2396, 2432, 2437, 2484, 2503, 2608, 2619, 2789, 2802, 2979, 3130, 3328, 3402, 3641, 3692, 3724, 3890, 3907, 4026, 4048], 'heterologous': [18, 260, 1758], 'cells': [19, 64, 261, 306, 485, 1889, 2027, 2513, 2626, 3148, 3255, 3348, 3418, 3438, 3747, 3793, 3912, 4013], 'or': [20, 69, 123, 262, 311, 365, 621, 1280, 2416, 2419, 2627, 3010, 3144, 3201, 3207, 3256, 3349, 3649, 3701, 3893, 3913], 'endogenously': [21, 263, 1624], 'striatal': [23, 78, 265, 320, 1893, 2092, 2628, 3195, 3259, 3404, 3647], 'neurons': [24, 79, 266, 321, 1636, 2629, 3196, 3405, 3648], 'where': [25, 267, 1437], 'it': [26, 268, 1846], 'mediate': [28, 270], 'Ca2+': [30, 82, 103, 203, 236, 272, 324, 345, 445, 478, 487, 499, 536, 549, 658, 674, 686, 693, 1028, 1323, 1822, 1900, 1902, 1919, 3131, 3247, 3344, 3504, 3521, 3600], 'changes.': [31, 273], 'Here,': [32, 274, 4116], 'pharmacological,': [33, 275], 'optical,': [34, 276], 'and': [35, 169, 196, 226, 277, 411, 438, 468, 521, 702, 881, 889, 1035, 1126, 1133, 1348, 1559, 1615, 1749, 1824, 1883, 1943, 1976, 2000, 2005, 2025, 2028, 2096, 2155, 2166, 2176, 2324, 2351, 2384, 2386, 2490, 2495, 2501, 2506, 2580, 2603, 2672, 2678, 2684, 2708, 2777, 2804, 2920, 2962, 2995, 3046, 3059, 3135, 3162, 3263, 3331, 3339, 3394, 3399, 3425, 3503, 3518, 3523, 3599, 3614, 3736, 3836, 3856, 3901, 3925, 4002, 4014, 4018, 4030, 4063, 4077, 4086, 4136, 4141], 'genetic': [36, 278], 'techniques': [37, 279, 2228, 4021], 'were': [38, 280, 1946, 2020, 2035, 2094, 2401, 2409, 2509, 2543, 2598, 2611, 2688, 2711, 2810, 2896, 2929, 3030, 3063, 3149, 3215, 3261, 3323, 3352, 3385, 3406, 3419, 3443, 3508, 3526, 3602, 3686, 3709, 3794, 3834, 3903, 4057], 'used': [39, 281, 713, 798, 2353, 2599, 3016, 3064, 3342, 3426, 4015, 4051], 'to': [40, 95, 97, 194, 198, 282, 337, 339, 436, 440, 502, 1024, 1122, 1208, 1373, 1379, 1446, 1542, 1544, 1621, 1849, 1881, 1895, 1913, 2153, 2173, 2272, 2931, 3024, 3325, 3333, 3698, 3705, 3733, 3895, 4022, 4052], 'show': [41, 283, 1870, 4053], 'upon': [43, 285], 'activation,': [44, 286], 'mGlu5': [46, 59, 92, 164, 191, 228, 288, 301, 334, 406, 433, 470, 1748, 1878, 2030, 2128, 2179, 2216, 2746, 3141, 3749, 3917, 3932, 4010, 4027, 4049, 4129, 4194], 'receptors': [47, 93, 192, 229, 289, 335, 434, 471, 708, 883, 1052, 1341, 1540, 1563, 1879, 4081, 4195], 'generate': [48, 199, 290, 441, 684, 1795, 1896], 'inositol': [50, 140, 292, 382, 706, 716, 781, 801, 866], '1,4,5-trisphosphate': [51, 293, 707, 717, 802], '(IP3)': [52, 294], 'in': [53, 62, 77, 157, 177, 207, 223, 234, 237, 295, 304, 319, 399, 419, 449, 465, 476, 479, 490, 507, 1037, 1064, 1068, 1325, 1434, 1757, 1791, 1829, 1843, 1855, 1886, 1905, 2898, 3017, 3065, 3132, 3212, 3249, 3431, 3643, 3646, 3652, 3684, 3726, 3746, 3791, 3839, 3909, 4011, 4196], 'situ.': [54, 296], 'Specifically,': [55, 297], 'expression': [56, 298], 'an': [58, 216, 300, 458, 1318, 4133, 4187], 'F767S': [60, 302, 2218], 'mutant': [61, 303, 2129, 2217, 3145], 'HEK293': [63, 305], 'blocks': [66, 308], 'Gq/11': [67, 96, 195, 309, 338, 437, 1545, 1882], 'coupling': [68, 310, 1383], 'introduction': [70, 312], 'a': [72, 144, 231, 238, 314, 386, 473, 480, 504, 508, 541, 689, 1326, 1742, 1914, 2279, 2311, 2427, 2584, 2665, 2794, 3730], 'dominant': [73, 315, 787, 872, 2331], 'negative': [74, 316, 788, 873, 2332], 'Gαq': [75, 317, 2333], 'construct': [76, 318, 2180, 2263, 2334, 2425, 2439], 'prevented': [80, 173, 322, 415], 'changes': [83, 325, 3248, 3505, 3642], 'following': [84, 160, 326, 402], 'activation.': [86, 328], 'These': [87, 329, 1428], 'data': [88, 330, 698, 1911], 'indicate': [89, 331], 'couple': [94, 193, 336, 435, 1543, 1620, 1880], 'mobilize': [98, 340], 'Ca2+.': [100, 179, 342, 421], 'Nuclear': [101, 343, 498, 535, 3058, 3400, 3926], 'mGlu5-mediated': [102, 175, 344, 417], 'responses': [104, 346], 'could': [105, 347, 1314, 1794, 1833], 'also': [106, 348, 1229, 1388, 1432, 1451], 'blocked': [108, 350], 'by': [109, 124, 351, 366, 697, 1103, 2133, 2213, 2230, 2488, 2623, 3055, 3688, 4124], 'phospholipase': [111, 353, 729, 814, 1119], 'C': [112, 354, 1120, 2007], '(PLC)': [113, 355, 1121], 'inhibitor,': [114, 356, 1957], 'U73122,': [115, 357], 'phosphatidylinositol': [117, 359, 734, 772, 819, 857, 1375, 1884], '(PI)': [118, 360], 'PLC': [119, 197, 361, 439, 1372, 1398], 'inhibitor': [120, 362], '1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphorylcholine': [121, 363], '(ET-18-OCH3),': [122, 364], 'using': [125, 143, 367, 385, 2164, 2225, 2443, 2583, 2613, 3032, 3528, 3604], 'small': [126, 368, 775, 860], 'interfering': [127, 369, 776, 861], 'RNA': [128, 370, 2377], 'targeted': [129, 371], 'against': [130, 372, 4044], 'PLCβ1': [131, 373, 2414, 3208], 'demonstrating': [132, 374], 'PI-PLC': [134, 376], 'is': [135, 377, 500, 695, 1047, 1062, 1101, 1193, 1707, 1853, 3933, 4121, 4132], 'involved.': [136, 378], 'Direct': [137, 379], 'assessment': [138, 380], 'phosphate': [141, 383, 1285], 'production': [142, 384, 1236], 'PIP2/IP3': [145, 387], '"biosensor"': [146, 388], 'revealed': [147, 389], 'for': [148, 390, 1234, 2600, 2682, 3343, 3427, 3612, 3617], 'first': [150, 392], 'time': [151, 393, 3732], 'IP3': [153, 168, 395, 410, 1066, 1124, 1183, 1210, 1333, 1380, 1390, 1832, 1852, 3429, 3501, 3524, 3598, 3685, 3894], 'generated': [156, 398, 1854, 2132, 2224], 'nucleus': [159, 212, 401, 454, 1074, 1189, 1200, 1228, 1313, 1436], 'activation': [161, 403, 703, 1129, 1396], 'receptors.': [165, 407], 'Finally,': [166, 408], 'both': [167, 409, 489, 1131, 1617, 4083], 'ryanodine': [170, 412, 765, 850, 882], 'blockers': [172, 414], 'increases': [176, 418], 'intranuclear': [178, 420], 'Collectively,': [180, 422], 'this': [181, 423], 'study': [182, 424], 'shows': [183, 425], 'like': [185, 427, 1872], 'plasma': [186, 428, 1448, 1873, 3060, 3696, 3936, 4029], 'membrane': [187, 429, 666, 1449, 1753, 1874, 2505, 2604, 3061, 3697, 3704], 'receptors,': [188, 430, 1613, 1875], 'activated': [189, 431, 1876, 1927], 'IP3-mediated': [200, 442, 1897], 'release': [201, 443, 567, 622, 659, 694, 1040, 1898, 1903], 'from': [204, 446, 540, 571, 623, 660, 1837, 1948, 1960, 1970, 1984, 1997, 2009, 2021, 2281, 2317, 2341, 2403, 2511, 2545, 2595, 2796, 2893, 3253, 3436, 3694, 3702], 'Ca2+-release': [205, 447, 1019], 'channels': [206, 448, 1020, 1904], 'nucleus.': [209, 451, 497, 1907], 'Thus': [210, 452, 1017], 'function': [214, 456, 1316], 'as': [215, 457, 493, 495, 514, 1116, 1118, 1317, 1371, 1547, 1553, 1555, 1890, 1892, 2037, 2099, 2207, 2354, 2426, 2447, 2514, 2552, 2589, 2639, 2641, 2648, 2712, 2811, 2934, 3068, 3100, 3164, 3217, 3265, 3353, 3445, 3542, 3657, 3722, 3738, 3750, 3796, 3887, 3905, 3938, 3940, 4075, 4186], 'autonomous': [217, 459], 'organelle': [218, 460], 'independent': [219, 461, 1319, 1921], 'signals': [221, 463, 488, 675, 1324], 'originating': [222, 464], 'cytoplasm,': [225, 467], 'play': [230, 472, 503], 'dynamic': [232, 474], 'role': [233, 475, 506], 'mobilizing': [235, 477], 'specific,': [239, 481, 1327], 'localized': [240, 482, 1328, 1443], 'fashion.': [241, 483, 1329], 'Many': [484], 'produce': [486], 'cytoplasm': [492, 1070], 'well': [494, 1117, 1554, 1891, 2640, 3939], 'thought': [501], 'vital': [505, 2644], 'variety': [509], 'functions': [512], 'such': [513, 1370, 1546, 4074], 'cell': [515, 1337, 1759, 2033, 2221, 3139], 'division,': [516], 'proliferation,': [517], 'protein': [518, 1745, 2276], 'import,': [519], 'apoptosis,': [520], 'gene': [522], 'transcription': [523], '(1Berridge': [524], 'M.J.': [525, 4153], 'Novartis': [526], 'Found.': [527], 'Symp.': [528], '2001;': [529, 1140, 1723, 2083, 2199, 2254, 2732, 2883, 3088, 3632], '239:': [530], '52-64Crossref': [531], 'PubMed': [532, 564, 590, 616, 652, 908, 934, 955, 980, 999, 1012, 1094, 1143, 1177, 1221, 1275, 1306, 1363, 1408, 1423, 1477, 1503, 1535, 1600, 1658, 1684, 1700, 1731, 1782, 2060, 2086, 2122, 2202, 2257, 2305, 2372, 2477, 2537, 2575, 2659, 2735, 2765, 2834, 2860, 2886, 2957, 3091, 3123, 3187, 3240, 3288, 3314, 3376, 3468, 3494, 3566, 3592, 3635, 3678, 3762, 3782, 3808, 3828, 3880, 3969, 3995, 4111, 4177], 'Google': [533, 565, 593, 619, 655, 911, 937, 958, 983, 1002, 1015, 1097, 1146, 1180, 1224, 1278, 1309, 1366, 1411, 1426, 1480, 1506, 1536, 1601, 1661, 1687, 1703, 1734, 1785, 2063, 2089, 2125, 2205, 2260, 2306, 2375, 2480, 2540, 2578, 2662, 2738, 2768, 2837, 2863, 2889, 2960, 3094, 3126, 3190, 3243, 3291, 3317, 3379, 3471, 3497, 3569, 3595, 3638, 3681, 3765, 3785, 3811, 3831, 3883, 3972, 3998, 4114, 4180], 'Scholar).': [534, 656, 1016, 1098, 1181, 1225, 1310, 1427, 1537, 1602, 1704, 1735, 1786, 2090, 2126, 2261, 2307, 2376, 2481, 2541, 2663, 2739, 2890, 3095, 3127, 3191, 3244, 3318, 3380, 3498, 3596, 3639, 3682, 3786, 3884, 3999, 4115], 'may': [537], 'mobilized': [539], 'number': [542, 2393], 'sources': [544], 'including': [545, 3945], 'diffusion': [546], 'cytosolic': [548, 1923], 'waves': [550], 'through': [551, 1926], 'pore': [553, 680], 'complexes': [554], '(2Power': [555], 'J.M.': [556, 2460, 3768, 3814, 3866], 'Sah': [557], 'P.': [558, 602, 642, 920, 988], 'J.': [559, 605, 644, 646, 923, 974, 990, 1089, 1166, 1300, 1358, 1466, 1492, 1529, 1594, 1647, 1673, 1695, 1720, 1771, 2049, 2111, 2471, 2526, 2564, 2754, 2823, 2849, 2946, 3112, 3176, 3229, 3277, 3303, 3365, 3457, 3483, 3555, 3581, 3631, 3667, 3756, 3802, 3958, 3984, 4100], 'Neurosci.': [560, 2655, 4172], '2002;': [561, 1420, 4174], '22:': [562], '3454-3462Crossref': [563], 'Scholar),': [566, 620, 2769, 2961, 3832], 'into': [568, 633, 1072, 2326], 'nucleoplasm': [570, 635, 1802], 'lumen': [574, 662], '(3Gerasimenko': [575, 893], 'O.V.': [576, 894, 973, 1299], 'Gerasimenko': [577, 895, 972, 1298], 'J.V.': [578, 896, 961, 1287], 'Tepikin': [579, 897, 968, 1294], 'A.V.': [580, 898, 969, 1295], 'Petersen': [581, 899, 970, 1296], 'O.H.': [582, 900, 971, 1297], 'Cell.': [583, 901, 1216, 2472, 3757, 3803], '1995;': [584, 902, 3759, 3805], '80:': [585, 903], '439-444Abstract': [586, 904], 'Full': [587, 611, 613, 905, 929, 931, 994, 996, 1172, 1174, 1472, 1474, 1498, 1500, 1653, 1655, 1679, 1681, 1726, 1728, 1777, 1779, 2055, 2057, 2117, 2119, 2300, 2302, 2532, 2534, 2570, 2572, 2760, 2762, 2829, 2831, 2855, 2857, 2952, 2954, 3118, 3120, 3182, 3184, 3235, 3237, 3283, 3285, 3309, 3311, 3371, 3373, 3463, 3465, 3489, 3491, 3561, 3563, 3587, 3589, 3673, 3675, 3964, 3966, 3990, 3992, 4106, 4108], 'Text': [588, 612, 614, 906, 930, 932, 995, 997, 1173, 1175, 1473, 1475, 1499, 1501, 1654, 1656, 1680, 1682, 1727, 1729, 1778, 1780, 2056, 2058, 2118, 2120, 2301, 2303, 2533, 2535, 2571, 2573, 2761, 2763, 2830, 2832, 2856, 2858, 2953, 2955, 3119, 3121, 3183, 3185, 3236, 3238, 3284, 3286, 3310, 3312, 3372, 3374, 3464, 3466, 3490, 3492, 3562, 3564, 3588, 3590, 3674, 3676, 3965, 3967, 3991, 3993, 4107, 4109], 'PDF': [589, 615, 907, 933, 998, 1176, 1476, 1502, 1657, 1683, 1730, 1781, 2059, 2121, 2304, 2536, 2574, 2764, 2833, 2859, 2956, 3122, 3186, 3239, 3287, 3313, 3375, 3467, 3493, 3565, 3591, 3677, 3968, 3994, 4110], 'Scopus': [591, 617, 653, 909, 935, 956, 981, 1000, 1013, 1095, 1144, 1178, 1222, 1276, 1307, 1364, 1409, 1424, 1478, 1504, 1659, 1685, 1701, 1732, 1783, 2061, 2087, 2123, 2203, 2258, 2373, 2478, 2538, 2576, 2660, 2736, 2766, 2835, 2861, 2887, 2958, 3092, 3124, 3188, 3241, 3289, 3315, 3377, 3469, 3495, 3567, 3593, 3636, 3679, 3763, 3783, 3809, 3829, 3881, 3970, 3996, 4112, 4178], '(349)': [592, 910], 'Scholar,': [594, 912, 938, 959, 984, 1003, 1147, 1412, 1481, 1507, 1662, 1688, 2064, 2838, 2864, 3292, 3472, 3570, 3766, 3812, 3973], '4Humbert': [595, 913], 'J.P.': [596, 914], 'Matter': [597, 915], 'N.': [598, 916, 1521, 3625], 'Artault': [599, 917], 'J.C.': [600, 918], 'Koppler': [601, 919], 'Malviya': [603, 921], 'A.N.': [604, 922], 'Biol.': [606, 924, 951, 976, 1167, 1217, 1271, 1302, 1467, 1493, 1648, 1674, 1721, 1772, 2050, 2112, 2296, 2527, 2565, 2755, 2824, 2850, 2947, 3113, 3177, 3230, 3278, 3304, 3366, 3458, 3484, 3556, 3582, 3668, 3778, 3824, 3876, 3959, 3985, 4101], 'Chem.': [607, 925, 1168, 1468, 1494, 1649, 1675, 1722, 1773, 2051, 2113, 2528, 2566, 2756, 2825, 2851, 2948, 3114, 3178, 3231, 3279, 3305, 3367, 3459, 3485, 3557, 3583, 3669, 3960, 3986, 4102], '1996;': [608, 926, 1405, 2757], '271:': [609, 927, 2758], '478-485Abstract': [610, 928], '(260)': [618, 936], 'so-called': [625], 'nucleoplasmic': [626, 669, 685, 891, 1027], 'reticulum,': [627], 'invaginations': [628], 'envelope': [632, 1570], 'itself': [636, 1706], '(5Alonso': [637], 'M.T.': [638, 944], 'Villalobos': [639], 'C.': [640, 1149, 1159, 1465, 1489, 1646, 1670, 1770, 2048, 2066, 2108, 2182, 2237, 2525, 2561, 2715, 2749, 2822, 2846, 2866, 2943, 3071, 3109, 3175, 3226, 3276, 3300, 3362, 3456, 3480, 3554, 3578, 3957, 3981, 4097], 'Chamero': [641], 'Alvarez': [643], 'Garcia-Sancho': [645], 'Cell': [647, 950, 975, 1270, 1301, 1961, 2023, 3006, 3398], 'Calcium.': [648], '2006;': [649, 1009, 1360, 1532, 1597, 2474], '40:': [650], '513-525Crossref': [651], '(82)': [654], 'Presumably': [657], 'and/or': [667, 682, 2697, 3392, 3535], 'reticulum': [670, 892, 4062], 'would': [671], 'either': [672, 2412], 'amplify': [673], 'arriving': [676], 'via': [677, 1392, 1857, 1901, 4082], 'complex': [681], 'independently': [683, 1025], 'transients.': [687], 'Such': [688], 'model': [690], 'bolstered': [696], 'documenting': [699], 'presence': [701, 4025], '(IP3': [709], 'Rs)': [710], '2The': [711, 796], 'abbreviations': [712, 797], 'are:': [714, 799], 'IP3Rs,': [715, 800], 'receptors;': [718, 722, 803, 807], 'GPCRs,': [719, 804], 'G': [720, 805, 1339], 'protein-coupled': [721, 806, 1340], 'mGlu5,': [723, 808, 1616], '5;': [727, 812], 'PLC,': [728, 813], 'C;': [730, 815], 'PI,': [731, 816], 'phosphatidylinositol;': [732, 817], 'PIP2,': [733, 818], '4,5-bisphosphate;': [735, 820], 'HEK,': [736, 821], 'human': [737, 822], 'embryonic': [738, 823], 'kidney;': [739, 824], 'EGFP,': [740, 825], 'enhanced': [741, 826, 2273, 3020], 'green': [742, 827, 2274], 'fluorescent': [743, 794, 828, 879, 2275, 2313, 3727], 'protein;': [744, 763, 829, 848], 'PH,': [745, 830], 'pleckstrin': [746, 831, 2266], 'homology;': [747, 832], 'MPEP,': [748, 833], '2-methyl-6-(phenylethynyl)-pyridine;': [749, 834], 'CPCCOEt,': [750, 835], '7-(hydroxyimino)cyclopropan[b]chromen-1a-carboxylate': [751, 836], 'ethyl': [752, 837, 1935], 'ester;': [753, 838], 'BAPTA,': [754, 839], '1,2-bis-(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic': [755, 840], 'acid;': [756, 785, 841, 870], '2-APB,': [757, 842], '2-aminoethoxydiphenyl': [758, 843], 'borate;': [759, 844], 'CREB,': [760, 845], 'cAMP-response': [761, 846], 'element-binding': [762, 847], 'RyR,': [764, 849], 'receptor;': [766, 851], 'IGF,': [767, 852], 'insulin-like': [768, 853, 1108], 'growth': [769, 854, 1109], 'factor;': [770, 855], 'PI3K,': [771, 856], '3-kinase;': [773, 858], 'siRNA,': [774, 859], 'RNA;': [777, 862], 'PC,': [778, 863], 'phosphatidylcholine;': [779, 864], 'IP,': [780, 865], 'phosphate;': [782, 867], 'LPA,': [783, 868], 'lysophosphatidic': [784, 869, 1560], 'DNGαq,': [786, 871], 'Gαq;': [789, 874], 'DsRed,': [790, 875], 'Discosoma': [791, 876], 'sp.': [792, 877], 'red': [793, 878, 2312], 'protein.': [795, 880], '(RyRs)': [884], 'inner': [886, 1628, 1751, 1865], '6Echevarria': [939], 'W.': [940], 'Leite': [941], 'M.F.': [942], 'Guerra': [943], 'Zipfel': [945], 'W.R.': [946], 'Nathanson': [947], 'M.H.': [948], 'Nat.': [949, 1213, 1269, 3775, 3821, 3873], '2003;': [952, 977, 1218, 1303, 1469, 1650, 1774, 2052, 2529, 2826, 3179, 3280, 3460, 3558, 3670, 3961], '5:': [953, 1010], '440-446Crossref': [954], '(314)': [957], '7Gerasimenko': [960], 'Maruyama': [962, 1288], 'Y.': [963, 1289, 1461, 1642, 1766, 2044, 2076, 2192, 2247, 2521, 2725, 2818, 2876, 3081, 3171, 3272, 3452, 3550, 3953], 'Yano': [964, 1290], 'K.': [965, 1291, 1586, 2070, 2186, 2241, 2361, 2456, 2719, 2870, 3075, 3772, 3818, 3870, 4149], 'Dolman': [966, 1292], 'N.J.': [967, 1293], '163:': [978, 1304], '271-282Crossref': [979, 1305], '(193)': [982, 1308], '8Quesada': [985], 'I.': [986], 'Verdugo': [987], 'Biophys.': [989], '2005;': [991, 1091, 1495, 1676, 2114, 2369, 2567, 2852, 2949, 3115, 3232, 3306, 3368, 3486, 3584, 3779, 3825, 3877, 3987, 4103], '88:': [992], '3946-3953Abstract': [993], '(10)': [1001], '9Marchenko': [1004], 'S.M.': [1005, 1080], 'Thomas': [1006, 1087], 'R.C.': [1007, 1088], 'Cerebellum.': [1008], '36-42Crossref': [1011], '(21)': [1014, 2479], 'these': [1018, 1051, 1910, 4004], 'are': [1021, 1054, 1623, 1790, 3720, 4143], 'perfectly': [1022], 'poised': [1023], 'regulate': [1026], 'levels.': [1029], 'Despite': [1030], 'importance': [1032, 1819], 'IP3Rs': [1034, 1078, 1135], 'RyRs': [1036], 'controlling': [1038, 1322], 'Ca2+,': [1043, 1924], 'very': [1044], 'little': [1045], 'information': [1046], 'available': [1048], 'regarding': [1049], 'how': [1050], 'themselves': [1053], 'activated.': [1055], 'One': [1056], 'most': [1059], 'prevalent': [1060], 'models': [1061], 'one': [1063], 'which': [1065, 1619], 'produced': [1067], 'diffuses': [1071], 'thereby': [1075], 'activating': [1076], '(10Marchenko': [1079], 'Yarotskyy': [1081], 'V.V.': [1082], 'Kovalenko': [1083], 'T.N.': [1084], 'Kostyuk': [1085], 'P.G.': [1086, 2470], 'Physiol.': [1090, 1138, 1530, 1595, 2473], '565:': [1092], '897-910Crossref': [1093], '(62)': [1096], 'This': [1099, 1191], 'premise': [1100], 'supported': [1102], 'studies': [1104, 1806, 2687, 4038], 'showing': [1105, 1197], 'extracellular': [1107], 'factor-1': [1110], '(IGF-1)': [1111], 'activates': [1112], 'its': [1113, 1349, 1838], 'own': [1114], 'stimulate': [1123], 'mobilization': [1125], 'ensuing': [1128], 'cytoplasmic': [1132, 2632], '(11Ito': [1136], 'M.': [1137, 1151, 1155, 1268, 1515, 1517, 1519, 1578, 1582, 2452], 'Rev.': [1139, 1214, 1402], '81:': [1141], '1143-1195Crossref': [1142], '(662)': [1145], '12Ibarra': [1148], 'Estrada': [1150], 'Carrasco': [1152], 'L.': [1153, 1254, 1580], 'Chiong': [1154], 'Liberona': [1156], 'J.L.': [1157], 'Cardenas': [1158], 'Diaz-Araya': [1160], 'G.': [1161, 1252, 1354, 1523, 1584, 4155], 'Jaimovich': [1162], 'E.': [1163, 1356], 'Lavandero': [1164], 'S.': [1165, 1262, 1525, 1592, 2072, 2074, 2188, 2190, 2243, 2245, 2292, 2367, 2464, 2721, 2723, 2872, 2874, 3077, 3079, 3621, 3629], '2004;': [1169], '279:': [1170], '7554-7565Abstract': [1171], '(71)': [1179], 'Alternatively,': [1182], 'might': [1184, 1331, 1431], 'synthesized': [1186], 'within': [1187, 1800], 'itself.': [1190, 1803], 'hypothesis': [1192], 'consistent': [1194], 'with': [1195, 1344, 1384, 1747, 1814, 2411, 2422, 2630, 2699, 2964, 3019, 3040, 3151, 3155, 3199, 3203, 3388, 3409, 3421, 3441, 3510, 3711, 4041, 4060], 'reports': [1196], 'contains': [1201], 'all': [1202, 2017, 3213], 'enzymatic': [1205], 'machinery': [1206], 'necessary': [1207, 1233], 'synthesize': [1209], '(13Irvine': [1211], 'R.F.': [1212], 'Mol.': [1215, 2081, 2197, 2252, 2730, 2881, 3086, 3777, 3823, 3875], '4:': [1219], '349-360Crossref': [1220], '(304)': [1223, 1365], 'Moreover,': [1226, 1736], 'has': [1230], 'components': [1232], 'RyR': [1239], 'agonists,': [1240], 'cyclic': [1241], 'ADP-ribose': [1242], '(14Adebanjo': [1243], 'O.A.': [1244], 'Anandatheerthavarada': [1245], 'H.K.': [1246], 'Koval': [1247], 'A.P.': [1248], 'Moonga': [1249], 'B.S.': [1250], 'Biswas': [1251], 'Sun': [1253], 'Sodam': [1255], 'B.R.': [1256], 'Bevis': [1257], 'P.J.': [1258], 'Huang': [1259], 'C.L.': [1260], 'Epstein': [1261], 'Lai': [1263], 'F.A.': [1264], 'Avadhani': [1265], 'N.G.': [1266], 'Zaidi': [1267], '1999;': [1272], '1:': [1273], '409-414Crossref': [1274], '(136)': [1277, 3784, 3830, 3882], 'Scholar)': [1279, 1367, 2163, 2206, 2579, 4181], 'nicotinic': [1281], 'acid': [1282, 1561, 1934], 'adenine': [1283], 'dinucleotide': [1284], '(7Gerasimenko': [1286], 'Thus,': [1311, 1787, 4185], 'potentially': [1315], 'signaling': [1320, 1788, 1823], 'unit': [1321], 'How': [1330], 'generated?': [1335], 'Typically,': [1336], 'surface': [1338], '(GPCRs)': [1342], 'associated': [1343, 1813, 3042, 4059], 'Gq-like': [1345], 'proteins': [1346, 1386], '(Gq': [1347], 'close': [1350], 'homolog,': [1351], 'G11)': [1352], '(15Milligan': [1353], 'Kostenis': [1355], 'Br.': [1357], 'Pharmacol.': [1359, 1403, 1531, 1596, 2082, 2198, 2253, 2731, 2882, 3087], '147:': [1361], 'S46-S55Crossref': [1362], 'activate': [1368, 4192], 'phospholipases': [1369], 'hydrolyze': [1374], '4,5-bisphosphate': [1376], '(PIP2)': [1377], 'leading': [1378], 'production.': [1381], 'GPCRs': [1382, 1439, 1861], 'Gi/o-like': [1385], 'increase': [1389], 'levels': [1391, 3790], 'dissociated': [1393], 'β/γ': [1394], 'subunit': [1395], '(16Exton': [1399], 'J.H.': [1400], 'Annu.': [1401], 'Toxicol.': [1404], '36:': [1406], '481-509Crossref': [1407], '(300)': [1410], '17Neves': [1413], 'S.R.': [1414, 3666], 'Ram': [1415], 'P.T.': [1416], 'Iyengar': [1417], 'R.': [1418, 1590, 2139, 4157], 'Science.': [1419], '296:': [1421], '1636-1639Crossref': [1422], '(979)': [1425], 'same': [1429], 'mechanisms': [1430], 'exist': [1433], 'several': [1438], 'been': [1441, 1565], 'recently': [1442], 'not': [1444], 'only': [1445], 'but': [1450], 'intracellularly': [1452], "(18O'Malley": [1456, 1637, 1761, 2039, 2516, 2813, 3166, 3267, 3447, 3545, 3948], 'K.L.': [1457, 1491, 1638, 1672, 1694, 1762, 2040, 2080, 2110, 2196, 2251, 2517, 2563, 2729, 2753, 2814, 2848, 2880, 2945, 3085, 3111, 3167, 3228, 3268, 3302, 3364, 3448, 3482, 3546, 3580, 3949, 3983, 4099], 'Jong': [1458, 1639, 1763, 2041, 2518, 2815, 3168, 3269, 3449, 3547, 3950], 'Y.J.': [1459, 1483, 1640, 1664, 1690, 1764, 2042, 2102, 2519, 2555, 2816, 2840, 2937, 3103, 3169, 3220, 3270, 3294, 3356, 3450, 3474, 3548, 3572, 3951, 3975, 4091], 'Gonchar': [1460, 1641, 1765, 2043, 2520, 2817, 3170, 3271, 3451, 3549, 3952], 'Burkhalter': [1462, 1643, 1767, 2045, 2522, 2819, 3172, 3273, 3453, 3551, 3954], 'A.': [1463, 1511, 1576, 1644, 1768, 2046, 2368, 2523, 2651, 2820, 3173, 3274, 3454, 3552, 3955], 'Romano': [1464, 1488, 1645, 1669, 1769, 2047, 2107, 2524, 2560, 2821, 2845, 2942, 3108, 3174, 3225, 3275, 3299, 3361, 3455, 3479, 3553, 3577, 3956, 3980, 4096], '278:': [1470, 1651, 1775, 2053, 2530, 2827, 3180, 3281, 3461, 3559, 3671, 3962], '28210-28219Abstract': [1471, 1652, 1776, 2054, 2531, 2828, 3181, 3282, 3462, 3560, 3963], '(107)': [1479, 1660, 1784, 2062, 2539, 2836, 3189, 3290, 3470, 3568, 3971], '19Jong': [1482, 1663, 2839, 3293, 3473, 3571, 3974], 'Kumar': [1484, 1665, 2103, 2556, 2841, 2938, 3104, 3221, 3295, 3357, 3475, 3573, 3976, 4092], 'V.': [1485, 1666, 2104, 2557, 2842, 2939, 3105, 3222, 3296, 3358, 3476, 3574, 3977, 4093], 'Kingston': [1486, 1667, 2105, 2558, 2843, 2940, 3106, 3223, 3297, 3359, 3477, 3575, 3978, 4094], 'A.E.': [1487, 1668, 2106, 2559, 2844, 2941, 3107, 3224, 3298, 3360, 3478, 3576, 3979, 4095, 4147], "O'Malley": [1490, 1671, 1693, 2079, 2109, 2195, 2250, 2562, 2728, 2752, 2847, 2879, 2944, 3084, 3110, 3227, 3301, 3363, 3481, 3579, 3982, 4098], '280:': [1496, 1677, 2115, 2568, 2853, 2950, 3116, 3233, 3307, 3369, 3487, 3585, 3988, 4104], '30469-30480Abstract': [1497, 1678, 2116, 2569, 2854, 2951, 3117, 3234, 3308, 3370, 3488, 3586, 3989, 4105], '(89)': [1505, 1686, 2124, 2577, 2862, 2959, 3125, 3242, 3316, 3378, 3496, 3594, 3997, 4113], '20Gobeil': [1508], 'F.': [1509, 1574], 'Fortier': [1510], 'Zhu': [1512], 'T.': [1513, 1572, 2147, 2283, 2294], 'Bossolasco': [1514, 1581], 'Leduc': [1516, 1577], 'Grandbois': [1518], 'Heveker': [1520], 'Bkaily': [1522, 1583], 'Chemtob': [1524, 1591], 'Barbaz': [1526], 'D.': [1527], 'Can.': [1528, 1593], '84:': [1533, 1598], '287-297Crossref': [1534], 'For': [1538, 3787], 'example,': [1539], 'known': [1541], 'prostaglandin': [1549], 'EP': [1550], 'EP1,': [1552], 'platelet-activating': [1557], 'factor': [1558], '(LPA-1)': [1562], 'found': [1566], '(21Zhu': [1571], 'Gobeil': [1573], 'Vazquez-Tello': [1575], 'Rihakova': [1579], 'Peri': [1585], 'Varma': [1587], 'D.R.': [1588], 'Orvoine': [1589], '377-391Crossref': [1599], 'Similarly,': [1603, 3192], 'Group': [1609], '1': [1610, 2394, 2904, 3854], 'mGlu1': [1614], 'Gq/11,': [1622], 'many': [1632, 3942], 'different': [1633], 'types': [1634, 1760], '22Jong': [1689], 'Schwetye': [1691], 'K.E.': [1692], 'Neurochem.': [1696], '2007;': [1697, 2656], '101:': [1698], '458-469Crossref': [1699], '(26)': [1702], 'Gq': [1705, 1744], 'present': [1708], '(23Hughes': [1712], 'T.E.': [1713], 'Zhang': [1714], 'H.': [1715, 2653, 3627], 'Logothetis': [1716], 'D.E.': [1717], 'Berlot': [1718], 'C.H.': [1719], '276:': [1724], '4227-4235Abstract': [1725], '(118)': [1733], 'previously': [1739, 3544, 3929], 'GFP-tagged': [1743], 'co-localizes': [1746], 'protein,': [1754, 2314], 'lamin': [1755, 3390], 'B2,': [1756, 3391], 'systems': [1789], 'place': [1792], 'requisite': [1797], 'second': [1798], 'messengers': [1799], 'Surprisingly,': [1804], 'few': [1805], 'directly': [1808], 'examined': [1809], 'signal': [1810], 'transduction': [1811], 'pathways': [1812], 'GPCRs.': [1816, 1929], 'Given': [1817], 'unlikelihood,': [1826], 'at': [1827, 3320, 3335, 3609, 3729, 3921], 'least': [1828], 'neurons,': [1830], 'diffuse': [1834, 3334], 'long': [1835], 'distances': [1836], 'presumed': [1839], 'site': [1840], 'synthesis': [1842], 'neuronal': [1844], 'processes,': [1845], 'seems': [1847], 'reasonable': [1848], 'propose': [1850], 'situ': [1856], 'actions': [1859], 'located': [1862], 'membrane.': [1867], 'Here': [1868], 'that,': [1871], '(PI)-PLC': [1885], 'mGlu5-expressing': [1887], 'HEK': [1888, 2032, 2220, 2512, 2625, 3147, 3254, 3650, 3911, 4012, 4125], 'nuclei': [1894, 2620, 3252, 3351, 3507, 3833, 3914, 4198], 'Taken': [1908], 'together,': [1909], 'point': [1912], 'novel': [1915], 'mode': [1916], 'generation,': [1920], 'mediated': [1925], 'Materials—Quisqualate,': [1930], '2-methyl-6-(phenylethynyl)-pyridine': [1931], '(MPEP),': [1932], '7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic': [1933], 'ester': [1936], '(CPCCOEt),': [1937], '1-(6-[17β-3-methoxyestra-1,3,5-(10)-triene-17-yl]amino/hexyl)1H-pyrrole-2,5-dione': [1938], '(U73122),': [1939], 'O-(octahydro-4,7-methano-1H-inden-5-yl)carbonopotassium': [1940], 'dithioate': [1941], '(D609),': [1942], '2-aminoethoxydiphenylborane': [1944], '(2-APB)': [1945], 'purchased': [1947, 1996, 2402], 'Tocris': [1949], 'Cookson': [1950], 'Inc.,': [1951, 1964, 1973, 1988, 2320, 2405, 2991], 'Ellisville,': [1952], 'MO.': [1953, 1991], 'Phosphatidylinositol': [1954], '3-kinase': [1955], '(PI3K)': [1956], 'LY294002': [1958], 'was': [1959, 1969, 1983, 1995, 2008, 2131, 2211, 2223, 2278, 2315, 2339, 2352, 2486, 2621, 2670, 2675, 2793, 3015, 3053, 3098, 3655, 3744, 4050], 'Signaling': [1962, 3007], 'Technology,': [1963, 2805, 3008], 'Beverly,': [1965], 'MA;': [1966, 1975], '[1-(4-aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine]': [1967], '(GYKI53655)': [1968], 'Research': [1971], 'Biochemicals': [1972], 'Natick,': [1974], 'myo-[2-3H]inositol': [1977], '(specific': [1978, 3048], 'activity': [1979, 3049], '=': [1980, 3050], '20.0': [1981], 'Ci/mmol)': [1982, 3052], 'American': [1985], 'Radiolabeled': [1986], 'Chemicals,': [1987], 'St.': [1989], 'Louis,': [1990], 'Optiprep™': [1992], '(60%': [1993], 'Iodixanol)': [1994], 'Accurate': [1998], 'Chemical': [1999], 'Scientific': [2001], 'Corporation,': [2002], 'Westbury,': [2003], 'NY,': [2004], 'xestospongin': [2006], 'Calbiochem,': [2010], 'San': [2011, 2159, 2784], 'Diego,': [2012, 2160], 'CA.': [2013], 'Unless': [2014], 'otherwise': [2015], 'indicated': [2016], 'other': [2018, 4037], 'chemicals': [2019], 'Sigma.': [2022], 'Culture': [2024], 'Plasmids—HEK293': [2026], 'stable': [2031, 2219], 'line': [2034, 2222], 'maintained': [2036, 2097], 'described': [2038, 2100, 2355, 2448, 2515, 2553, 2649, 2713, 2812, 2935, 3069, 3101, 3165, 3218, 3266, 3354, 3446, 3543, 3658, 3751, 3797], '24Romano': [2065, 2865], 'Miller': [2067, 2183, 2238, 2716, 2867, 3072], 'J.K.': [2068, 2184, 2239, 2717, 2868, 3073], 'Hyrc': [2069, 2185, 2240, 2718, 2869, 3074], 'Dikranian': [2071, 2187, 2242, 2720, 2871, 3076], 'Mennerick': [2073, 2189, 2244, 2722, 2873, 3078], 'Takeuchi': [2075, 2191, 2246, 2724, 2875, 3080], 'Goldberg': [2077, 2193, 2248, 2726, 2877, 3082], 'M.P.': [2078, 2194, 2249, 2727, 2878, 3083, 4151], '59:': [2084, 2200, 2255, 2733, 2884, 3089], '46-53Crossref': [2085, 2201, 2256, 2734, 2885, 3090], '(122)': [2088, 2204, 2259, 2737, 2888, 3093], 'Primary': [2091, 2740], 'cultures': [2093], 'prepared': [2095, 2510, 2544, 3216, 3262, 3435, 3835], 'exactly': [2098], '(19Jong': [2101, 2554, 2936, 3102, 3219, 3355, 4090], 'The': [2127, 2209, 2215, 2262, 2330, 2482], '(F767S)': [2130], 'recombinant': [2134], 'polymerase': [2135], 'chain': [2136], 'reaction': [2137], '(25Higuchi': [2138], 'Innis': [2140], 'M.A.': [2141], 'Gelfand': [2142], 'D.H.': [2143], 'Sninsky': [2144], 'J.J.': [2145], 'White': [2146], 'J': [2148], 'PCR': [2149], 'Protocols:': [2150], 'A': [2151], 'Guide': [2152], 'Methods': [2154], 'Applications.': [2156], 'Academic': [2157], 'Press,': [2158], 'CA1990:': [2161], '177-183Google': [2162], 'sense': [2165, 2398], 'antisense': [2167], 'primers': [2168], 'containing': [2169, 2264, 2336], 'relevant': [2171], 'phenylalanine': [2172], 'serine': [2174], 'mutation': [2175, 2210], 'wild': [2177, 3142], 'type': [2178, 3143], '(24Romano': [2181, 2236, 2714, 3070], 'template.': [2208], 'confirmed': [2212, 2487], 'sequencing.': [2214], 'standard': [2226], 'transfection': [2227, 2428], 'followed': [2229], 'repetitive': [2231], 'rounds': [2232], 'limiting': [2234], 'dilution': [2235], 'homology': [2267], 'domain': [2268], 'PLCδ1': [2270], 'fused': [2271], '(pEGFP-C1-PLCδ1-PH)': [2277], 'gift': [2280, 2795], 'Dr.': [2282, 2797], 'Meyer,': [2284], 'Stanford': [2285], 'University,': [2286], 'Stanford,': [2287], 'CA': [2288], '(26Stauffer': [2289], 'T.P.': [2290], 'Ahn': [2291], 'Meyer': [2293], 'Curr.': [2295], '1998;': [2297], '8:': [2298, 2657], '343-346Abstract': [2299], 'pDsRed2': [2308], 'encoding': [2309], 'DsRed2,': [2310], 'obtained': [2316, 2340, 2892], 'Clontech': [2318], 'Laboratories,': [2319, 2783], 'Mountain': [2321], 'View,': [2322], 'CA,': [2323], 'subcloned': [2325], 'pcDNA3': [2328], 'vector.': [2329], '(pcDNA3.1+Gαq': [2335], 'mutations': [2337], 'Q209L/D277N)': [2338], 'University': [2343, 2801, 2978], 'Missouri': [2345], 'cDNA': [2346], 'Resource': [2347], 'Center,': [2348], 'Rolla,': [2349], 'MO,': [2350], '(27Lauckner': [2356], 'J.E.': [2357], 'Hille': [2358], 'B.': [2359], 'Mackie': [2360], 'Proc.': [2362], 'Natl.': [2363], 'Acad.': [2364], 'Sci.': [2365], 'U.': [2366], '102:': [2370], '19144-19149Crossref': [2371], '(258)': [2374], 'Interference—On-Target': [2378], 'plus': [2379, 2388], 'siRNA': [2380, 2392, 2415, 2418, 2433], 'duplex': [2381], 'targeting': [2382], 'PLCβ1(5′-CAGUUGAAUUUGUCGAAUAUU-3′': [2383], '5′-PUAUUCGACAAAUUCAACUGUU-3′)': [2385], 'On-Target': [2387], 'scrambled': [2389, 2417, 3205], 'siControl': [2390], 'non-targeting': [2391], '(sequence': [2395], 'strand': [2399], '5′-UGGUUUACAUGUCGACUAA-3′)': [2400], 'Dharmacon,': [2404], 'Chicago,': [2406], 'IL.': [2407], 'Neurons': [2408], 'transfected': [2410, 3198, 3408, 3440], 'co-transfected': [2420, 3202], 'along': [2421], 'DsRed2': [2424, 3200], 'marker': [2429], '(2': [2430, 3411], 'μg': [2431, 3412], '+': [2434], '200': [2435], 'ng': [2436], 'pcDNA3-DsRed2': [2438], 'per': [2440, 2590], '35-mm': [2441, 2700, 3413], 'dishes)': [2442], 'Lipofectamine': [2444], '2000': [2445], '(Invitrogen)': [2446, 3424], '(28Kim': [2449], 'Y.H.': [2450], 'Song': [2451], 'Oh': [2453], 'Y.S.': [2454], 'Heo': [2455], 'Choi': [2457], 'J.W.': [2458], 'Park': [2459], 'Kim': [2461], 'S.H.': [2462, 2468], 'Lim': [2463], 'Kwon': [2465], 'H.M.': [2466], 'Ryu': [2467], 'Suh': [2469, 2799], '207:': [2475], '689-696Crossref': [2476], 'efficacy': [2483], 'knockdown': [2485], 'immunocytochemistry': [2489], 'Western': [2491, 2679], 'blot': [2492], 'analysis': [2493], '48': [2494], '72': [2496], 'h': [2497, 3417], 'post-transfection.': [2498], 'Subcellular': [2499], 'Fractionation': [2500], 'Preparation': [2502], 'Nuclei—Plasma': [2504], 'fractions': [2508, 3062], 'Nuclei': [2542, 3434], 'postnatal': [2546], 'day': [2547], '10': [2548, 3852], '(P10)': [2549], 'rat': [2550, 3257], 'striata': [2551], 'further': [2581, 3864], 'purified': [2582, 2744], '25-35%': [2585], '(w/v)': [2586], 'iodixanol': [2587], 'gradient': [2588], "manufacturer's": [2592], 'instructions.': [2593], 'Aliquots': [2594], 'each': [2596, 2609], 'fraction': [2597, 2610], 'gel': [2601], 'electrophoresis': [2602], 'binding.': [2605], 'Protein': [2606], 'concentrations': [2607], 'determined': [2612], 'Bradford': [2615], 'assay': [2616], '(Bio-Rad).': [2617], 'Purity': [2618], 'assessed': [2622], 'loading': [2624], 'mitochondrialselective': [2633], 'stain': [2634], 'MitoTracker': [2635], 'Deep': [2636], 'Red': [2637], '633': [2638], 'DNA-specific': [2643], 'dye,': [2645], 'Hoechst': [2646], '33258': [2647], '(29Eder': [2650], 'Bading': [2652], 'BMC': [2654], '57Crossref': [2658], '(37)': [2661], 'After': [2664, 3415], '20-min': [2666], 'preincubation,': [2667], 'subcellular': [2668, 2894], 'fractionation': [2669, 2895], 'performed': [2671, 3031, 3099, 3656], 'staining': [2674], 'monitored.': [2676], 'Immunocytochemistry': [2677], 'Blot': [2680], 'Analysis—Cells': [2681], 'immunocytochemical': [2683], 'confocal': [2685, 3531], 'microscopic': [2686], 'grown': [2689], 'poly-d-lysine-treated': [2691], 'glass': [2692, 2701], 'coverslips,': [2693], '8-well': [2694], 'chamber': [2695], 'slides,': [2696], 'dishes': [2698], 'grids': [2702], '(Mat-Tek,': [2703], 'Ashland,': [2704], 'MA).': [2705], 'Fixation,': [2706], 'blocking,': [2707], 'antibody': [2709, 4017], 'incubation': [2710], 'antibodies': [2741, 2809, 4042], 'included': [2742], 'affinity': [2743], 'anti-C-terminal': [2745], '(1:250)': [2747], '(30Romano': [2748], 'Yang': [2750], 'W.L.': [2751], '28612-28616Abstract': [2759], '(445)': [2767], 'rabbit': [2770], 'polyclonal': [2771], 'anti-mGlu5': [2772, 2965], '(1:200;': [2773], 'Upstate/Millipore,': [2774], 'Charlottesville,': [2775], 'VA),': [2776], 'monoclonal': [2778, 2970, 2984, 2996], 'anti-lamin': [2779, 2967], 'B2': [2780, 2968], '(1:100;': [2781], 'Zymed': [2782], 'Francisco,': [2785], 'CA).': [2786], 'Anti-PLCβ1': [2787], '(1:300': [2788], 'mouse': [2790], 'monoclonal,': [2791], 'K92)': [2792], 'Pann-Ghill': [2798], '(Pohang': [2800], 'Science': [2803], 'South': [2806], 'Korea).': [2807], 'Secondary': [2808], 'Proteins': [2891], 'resuspended': [2897, 3838], 'lysis': [2899], 'buffer': [2900, 3841], '(150': [2901], 'mm': [2902, 2905, 2916], 'NaCl,': [2903], 'EDTA,': [2906], '0.1%': [2907], 'SDS,': [2908], '1%': [2909], 'Nonidet': [2910], 'P-40,': [2911], '0.5%': [2912], 'sodium': [2913], 'deoxycholate,': [2914], '50': [2915], 'Tris-HCl,': [2917], 'pH': [2918, 3859], '7.5,': [2919], 'protease': [2921], 'inhibitors': [2922], 'Complete': [2923], 'Tablets;': [2924], 'Roche': [2925], 'Applied': [2926], 'Science).': [2927], 'Lysates': [2928], 'subjected': [2930], 'SDS-PAGE,': [2932], 'blotted': [2933], 'probed': [2963], '(1:1000),': [2966], '(1:2000),': [2969], 'anti-Na+K+-ATPase': [2971], '(α-6F,': [2972], '1:1000;': [2973], 'Development': [2974], 'Studies': [2975], 'Hybridoma': [2976], 'Bank,': [2977], 'Iowa,': [2980], 'Iowa': [2981], 'City,': [2982], 'IA),': [2983], 'anti-PLCβ1': [2985], '(1:200,': [2986], 'D-8:sc-5291;': [2987], 'Santa': [2988, 2992], 'Cruz': [2989], 'Biotechnology,': [2990], 'Cruz,': [2993], 'CA),': [2994], 'anti-β-actin': [2997], '(1:5000;': [2998], 'Sigma).': [2999], 'Horseradish': [3000], 'peroxidase-conjugated': [3001], 'goat': [3002], 'anti-rabbit': [3003], 'IgG': [3004, 3012], '(1:2000;': [3005, 3013], 'Inc.)': [3009], 'anti-mouse': [3011], 'Sigma)': [3014], 'conjunction': [3018], 'chemiluminescence': [3021], '(Amersham': [3022], 'Biosciences)': [3023], 'detect': [3025], 'signal.': [3027], 'Densitometric': [3028], 'analyses': [3029], 'Storm': [3034], '860': [3035], 'Imager': [3036], '(GE': [3037], 'Healthcare)': [3038], 'together': [3039], 'software.': [3043, 3718], '[3H]Quisqualate': [3044, 3096], 'Binding': [3045], 'Uptake—[3H]Quisqualate': [3047], '26.0': [3051], 'made': [3054], 'SRI': [3056], 'International.': [3057], 'binding': [3066], 'assays': [3067], 'uptake': [3097], 'Fluorescent': [3128], 'Measurements': [3129], 'Intact': [3133], 'Cells': [3134], 'Isolated': [3136], 'Nuclei—For': [3137], 'whole': [3138], 'measurements,': [3140], 'expressing': [3146, 3748, 3915], 'washed': [3150, 3420], 'serum-free': [3152], 'medium,': [3153], 'incubated': [3154], 'Oregon': [3156], 'Green': [3157], '488': [3158], 'BAPTA-1AM': [3159], '(Molecular': [3160, 3514], 'Probes)': [3161], 'imaged': [3163, 3444], 'primary': [3193], 'cultured': [3194], 'transiently': [3197, 3407, 3439], 'DNGαq/DsRed2,': [3204], 'siRNA/DsRed2,': [3206], 'siRNA/DsRed2': [3209], '(10:1': [3210], 'ratio': [3211, 3723, 3889], 'cotransfections)': [3214], 'To': [3245, 3499, 4000], 'measure': [3246], 'individual': [3250], 'nuclei,': [3251, 3651, 3792], 'P10': [3258], 'tissues': [3260], 'processed': [3264, 3710, 3863], 'Drugs': [3319], '×100': [3321], 'concentration': [3322], 'added': [3324], 'side': [3327], 'dish': [3330], 'allowed': [3332], 'room': [3336], 'temperature.': [3337], 'Extra-': [3338], 'intracellular': [3340, 3840, 3943], 'buffers': [3341], 'measurements': [3345, 3522, 3601], 'intact': [3347], 'isolated': [3350, 4197], 'Following': [3381], 'image': [3382], 'collection,': [3383], 'cells/nuclei': [3384], 'fixed,': [3386], 'stained': [3387], 'anti-mGlu5,': [3389], 'PLCβ1,': [3393], 'field': [3395], 'relocated.': [3396], 'Single': [3397], 'Imaging': [3401], 'IP3—Dissociated': [3403], 'pEGFP-C1-PLCδ1-PH': [3410, 3442], 'dishes-1).': [3414], '24-48': [3416], 'Neurobasal': [3422], 'medium': [3423], 'monitoring': [3428], 'generation': [3430, 3502], 'real': [3432, 3653], 'time.': [3433], 'mGlu5/HEK': [3437], 'monitor': [3500], 'simultaneously,': [3506], 'loaded': [3509], 'Calcium': [3511, 3618], 'Crimson': [3512, 3619], 'AM': [3513], 'Probes).': [3515], 'Confocal': [3516], 'Microscopy': [3517], 'Data': [3519, 3719, 3885], 'Analysis—All': [3520], 'imaging': [3525], 'done': [3527, 3603], 'laser': [3529], 'scanning': [3530], 'microscopes': [3532], 'FluoView': [3533, 3536], '500': [3534], '1000': [3537], '(Olympus,': [3538], 'Center': [3539], 'Valley,': [3540], 'PA)': [3541], 'Simultaneous': [3597], 'bandpass': [3605], 'barrier': [3606], 'filter': [3607], 'settings': [3608], '483-536': [3610], 'nm': [3611, 3616], 'EGFP': [3613, 3693], '590-680': [3615], '(31Bolsover': [3620], 'Ibrahim': [3622], 'O.': [3623], "O'Luanaigh": [3624], 'Williams': [3626], 'Cockcroft': [3628], 'Biochem.': [3630, 3758, 3804], '356:': [3633], '345-352Crossref': [3634], '(41)': [3637], 'Analysis': [3640, 3717], 'GFP': [3644], 'fluorescence': [3645, 3735], 'time,': [3654], '(32Young': [3659], 'K.W.': [3660], 'Nash': [3661], 'M.S.': [3662], 'Challiss': [3663], 'R.A.': [3664, 4159], 'Nahorski': [3665], '20753-20760Abstract': [3672], '(54)': [3680], 'Increases': [3683], 'detected': [3687], 'measuring': [3689, 3788], 'translocation': [3691], 'cytosol': [3700], 'nucleoplasm.': [3707], 'Images': [3708], 'MetaMorph': [3712], '(version': [3713], '5.0.7)': [3714], 'Professional': [3715], 'Image': [3716], 'presented': [3721], 'change': [3725], 'intensity': [3728], 'given': [3731], 'initial': [3734], 'percentage': [3739, 3906], '(ΔF/Fo,': [3740], '%).': [3741], '[3H]IP': [3742], 'Measurements—IP': [3743], 'measured': [3745], '(33Sorensen': [3752, 3798], 'A.M.': [3753, 3799], 'Baran': [3754, 3800], 'D.T.': [3755, 3801], '58:': [3760, 3806], '15-21Crossref': [3761, 3807], '(15)': [3764, 3810], '34Klco': [3767, 3813], 'Wiegand': [3769, 3815, 3867], 'C.B.': [3770, 3816, 3868], 'Narzinski': [3771, 3817, 3869], 'Baranski': [3773, 3819, 3871], 'T.J.': [3774, 3820, 3872], 'Struct.': [3776, 3822, 3874], '12:': [3780, 3826, 3878], '320-326Crossref': [3781, 3827, 3879], 'IP': [3789, 3892], 'treated': [3795], 'then': [3837], '(in': [3842], 'mm:': [3843], '125': [3844], 'KCl,': [3845], '2': [3846, 3848], 'KH2PO4,': [3847], 'MgCl2,': [3849], '0.3': [3850], 'CaCl2,': [3851], 'd-glucose,': [3853], 'ATP': [3855], '40': [3857], 'HEPES': [3858], '7.0)': [3860], 'before': [3861], 'being': [3862], '(34Klco': [3865], 'calculated': [3886], 'labeled': [3891], 'total': [3896], 'radioactivity': [3897], '(inositol,': [3898], 'IP1,': [3899], 'IP2,': [3900], 'IP3)': [3902], 'response': [3908], 'unstimulated': [3910], 'mGlu5.': [3916], 'Receptors': [3918], 'Are': [3919], 'Localized': [3920], 'Both': [3922], 'Plasma': [3924], 'Membranes—We': [3927], 'confirm': [4001, 4118], 'extend': [4003], 'studies,': [4005], 'N-terminal': [4008], 'hemagglutinin-tagged': [4009], 'anti-hemagglutinin': [4016], 'differential': [4019], 'permeabilization': [4020], 'verify': [4023], '(supplemental': [4033, 4066, 4182], 'Fig.': [4034, 4067, 4183], 'S1).': [4035, 4068], 'In': [4036], 'immunogold': [4039, 4055], 'EM': [4040], 'directed': [4043], 'C-terminal': [4046], 'portion': [4047], 'particles': [4056], 'abundantly': [4058], 'endoplasmic': [4061], 'Previously': [4069], 'showed': [4071], 'agonists': [4073], 'quisqualate': [4078, 4120], 'reach': [4079], 'sodium-dependent': [4084], 'transporters': [4085], 'cystine': [4087], 'exchangers': [4089], 'taken': [4122], 'up': [4123], 'cells,': [4126], 'agonist': [4130], '3,5-dihydroxyphenylglycine': [4131, 4190], 'impermeable': [4134, 4144, 4188], 'agonist,': [4135, 4189], 'drugs': [4139], 'LY395053': [4140], 'LY367366': [4142], 'antagonists': [4145], '(35Kingston': [4146], 'Griffey': [4148], 'Johnson': [4150, 4160], 'Chamberlain': [4152], 'Kelly': [4154], 'Tomlinson': [4156], 'Wright': [4158], 'B.G.': [4161], 'Schoepp': [4162], 'D.D.': [4163], 'Harris': [4164], 'J.R.': [4165], 'Clark': [4166], 'B.P.': [4167], 'Baker': [4168], 'R.S.': [4169], 'Tizzano': [4170], 'J.T.': [4171], 'Lett.': [4173], '330:': [4175], '127-130Crossref': [4176], '(36)': [4179], 'S2).': [4184], 'cannot': [4191]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1994363140', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-07T06:39:47.310419', 'created_date': '2016-06-24'}