Title: Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities
Abstract: It has been previously shown that some flavonoids inhibit NF-κB; however, the structure-activity relationships between chalcone, flavanone, flavone, and isoflavone derivatives and their TNFα induced NF-κB inhibitory effects on HCT116 human colon cancer cells have not yet been reported. Therefore, in this study, the effects of flavonoid structure on inhibition of NF-κB were investigated. Based on the combined results of this study, the structure of the flavonoids was shown to affect NF-κB activation.
Publication Year: 2011
Publication Date: 2011-10-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 50
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