Signaling Pathways Underlying Muscarinic Receptor-induced [Ca2+] Oscillations in HEK293 Cells

Name: Work Video:
Duration: 3 min 30 s
Dali Luo; Lisa M. Broad; Gary S. Bird; James W. Putney
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3979, 4041], 'biphasic': [31, 252, 564], 'rise': [32, 253, 3364, 3934], 'cytoplasmic': [34, 255, 1715], '([Ca2+]i)': [36, 257, 469], 'comprised': [37, 258, 567], 'release': [39, 260, 878, 928, 1284, 2198, 2703, 3450, 3534, 3645, 3658, 3670, 3697, 3907, 4039, 4069, 4146, 4179], 'Ca2+': [41, 48, 78, 130, 192, 262, 269, 299, 351, 413, 505, 508, 514, 523, 565, 580, 584, 591, 600, 609, 669, 880, 927, 1035, 1054, 1112, 1277, 1283, 1288, 1445, 1496, 1540, 1716, 2182, 2191, 2200, 2205, 2308, 2529, 2598, 2631, 2685, 2702, 2777, 2895, 2943, 3036, 3053, 3074, 3086, 3100, 3134, 3241, 3269, 3375, 3387, 3449, 3452, 3537, 3583, 3596, 3618, 3644, 3657, 3696, 3699, 3906, 3977, 3993, 4004, 4025, 4038, 4068, 4124, 4178, 4181, 4208, 4283, 4306, 4335, 4381], 'from': [42, 49, 263, 270, 506, 515, 572, 595, 731, 881, 975, 1225, 1285, 1290, 1509, 1793, 2052, 2065, 2201, 3226, 3474, 4185], 'intracellular': [43, 264, 466, 599, 3030], 'stores': [44, 265, 509, 601, 883], 'and': [45, 83, 151, 206, 218, 266, 304, 372, 427, 439, 490, 492, 539, 602, 717, 796, 876, 988, 1109, 1173, 1287, 1438, 1442, 1480, 1528, 1553, 1609, 1642, 1673, 1729, 1788, 1809, 1836, 2027, 2030, 2047, 2059, 2109, 2204, 2333, 2374, 2457, 2555, 2563, 2626, 2695, 2708, 2768, 2853, 2944, 3012, 3101, 3145, 3208, 3259, 3268, 3345, 3386, 3420, 3489, 3588, 3607, 3613, 3698, 3704, 3743, 3860, 3867, 4048, 4094, 4156, 4180, 4192, 4249, 4317, 4416, 4436], 'influx': [46, 267, 1289, 3619, 3978, 4182, 4304, 4382], 'extracellular': [51, 73, 272, 294, 517, 1184, 1292, 1732, 2043, 2522, 2942, 3872], 'space.': [52, 273, 518], 'A': [53, 274, 2707, 3482, 3918], 'lower': [54, 275, 732], '(5': [58, 279], 'repetitive': [61, 282, 719, 2266, 4242], '[Ca2+]i': [62, 134, 166, 195, 283, 355, 387, 416, 496, 725, 788, 995, 1040, 1416, 1460, 1635, 1698, 1849, 2002, 2161, 2207, 2270, 2295, 2719, 2844, 2934, 2957, 3010, 3286, 3327, 3363, 3371, 3409, 3463, 3520, 3672, 3936, 4145, 4272, 4338], 'spikes': [63, 284, 2313], 'or': [64, 285, 527, 727, 938, 1232, 1566, 1859, 1992, 2483, 2801, 2833, 2839, 3002, 3117, 3451, 3570, 3682, 3986], 'oscillations,': [65, 286, 4339], 'continuation': [67, 288], 'which': [69, 290, 664, 1998, 2254, 2341, 3580, 4081, 4174], 'was': [70, 92, 142, 152, 168, 175, 291, 313, 363, 373, 389, 396, 1760, 1819, 2016, 2073, 2124, 2192, 2358, 2366, 2386, 2394, 2431, 2442, 2466, 2856, 2879, 3043, 3485, 3899, 3994, 4051, 4278, 4285, 4411, 4418, 4447], 'dependent': [71, 292], 'on': [72, 293, 2521, 2597, 2622, 2700, 2717, 2842, 3085, 3240, 3447, 3492, 3555, 3568, 3595, 3676, 3922, 4321, 4334], 'Ca2+.': [74, 295], 'The': [75, 296, 785, 1781, 1949, 2723, 2865, 2953, 3517, 3894, 4266], 'entry': [76, 131, 140, 163, 193, 212, 297, 352, 361, 384, 414, 433, 512, 585, 592, 640, 652, 1036, 1052, 1055, 1113, 1446, 1497, 2189, 2539, 2566, 2599, 2629, 2643, 2686, 2729, 2778, 2798, 3054, 3069, 3203, 3270, 3388, 3453, 3584, 3597, 3700, 3737, 3787, 4005, 4026, 4125, 4201, 4209, 4336], '100': [80, 155, 179, 301, 376, 400, 1724, 2137, 2852, 3281, 3683, 3876, 3981, 4043, 4055, 4060, 4109, 4137, 4250, 4426], 'μm': [81, 102, 156, 180, 302, 323, 377, 401, 1617, 1709, 2138, 2217, 2273, 2282, 2399, 2475, 2835, 3001, 3116, 3282, 3321, 3457, 3623, 3634, 3680, 3684, 3877, 3982, 4018, 4034, 4044, 4056, 4061, 4073, 4129, 4138, 4151, 4251, 4264, 4276, 4427], 'sarcoplasmic-endoplasmic': [86, 307, 456], 'reticulum': [87, 308, 445, 457, 574, 4093], 'ATPase': [89, 310, 459], 'inhibitor,': [90, 110, 311, 331, 2604], 'thapsigargin,': [91, 312, 2058, 2605, 3589, 3859, 4136], 'completely': [93, 176, 314, 397, 3581, 4253, 4448], 'blocked': [94, 177, 315, 398, 3582, 4254, 4419], 'by': [95, 145, 154, 172, 178, 316, 366, 375, 393, 399, 502, 511, 525, 577, 663, 891, 936, 1177, 1236, 1295, 1681, 1762, 1786, 1821, 2018, 2151, 2215, 2368, 2514, 2612, 2688, 2732, 2739, 2790, 2927, 3091, 3222, 3229, 3366, 3391, 3455, 3466, 3487, 3523, 3539, 3621, 3713, 3790, 3908, 3937, 3980, 4042, 4173, 4197, 4268, 4287, 4386], '1': [96, 317, 1616, 1708, 2195, 2216, 2318, 2351, 2416, 2591, 3092, 3578, 3679, 3909, 3987, 4072], 'μmGd3+,': [97, 318, 2855, 3041], 'as': [98, 100, 319, 321, 558, 724, 1491, 1571, 1734, 1953, 2032, 2075, 2111, 2501, 2588, 3849, 3966], 'well': [99, 320], '30–100': [101, 322], 'concentrations': [103, 148, 324, 369, 733, 2827, 2850, 2872, 2898, 2950, 2998, 3108, 3216, 3279, 3610, 3939], 'membrane-permeant': [106, 327, 3815], 'inositol': [107, 328, 442, 543], '1,4,5-trisphosphate': [108, 329, 443, 544], 'receptor': [109, 330, 1475, 2783, 3820], '2-aminoethyoxydiphenyl': [111, 332, 454], 'borane': [112, 333, 455, 2071], '(2-APB).': [113, 334], 'Sensitivity': [114, 335], 'to': [115, 170, 336, 391, 536, 583, 704, 803, 942, 982, 990, 993, 1182, 1420, 1436, 1545, 1713, 1960, 1965, 1968, 2183, 2212, 2263, 2317, 2462, 2559, 2601, 2617, 2635, 2730, 2736, 2780, 2788, 2793, 2814, 2875, 2936, 2959, 2968, 3027, 3063, 3214, 3248, 3294, 3319, 3349, 3376, 3472, 3531, 3563, 3586, 3600, 3660, 3711, 3724, 3788, 3856, 3858, 3861, 3930, 3996, 4071, 4085, 4105, 4127, 4149, 4204, 4211, 4262, 4274, 4326], 'these': [116, 337, 1463, 1720, 2869, 2962, 3020, 3707], 'inhibitors': [117, 338], 'is': [118, 200, 339, 421, 529, 606, 979, 1037, 1042, 1165, 1999, 2532, 2632, 2734, 2772, 2799, 2883, 2964, 3220, 3526, 3718, 3781, 4308, 4384], 'indicative': [119, 340], 'capacitative': [121, 210, 342, 431, 650, 1050, 2562, 2641, 2727, 3067, 3571, 3727, 3735, 3785, 4118, 4199], 'entry.': [123, 344, 2206, 3037, 3573, 3729], 'Arachidonic': [124, 345, 1163, 1219, 2045], 'acid,': [125, 346, 1488, 3224, 3414, 3459], 'candidate': [127, 348], 'signal': [128, 349, 475, 662, 1278, 3011], 'for': [129, 190, 216, 350, 411, 437, 477, 805, 1281, 1472, 1631, 1644, 1719, 1727, 1844, 1852, 2115, 2360, 2401, 2444, 2504, 2528, 3778, 3932, 3967, 4027, 4135], 'associated': [132, 164, 353, 385, 1458], 'HEK293': [137, 198, 358, 419, 1448, 1569, 1984, 2220, 2257, 2499, 3077, 3206, 3244, 3395, 3702, 3888, 4215, 4260], 'cells,': [138, 359, 2340, 2500, 3703, 3866, 4415], 'that': [141, 185, 362, 406, 1049, 1102, 1269, 1697, 1966, 2430, 2737, 2796, 2885, 3051, 3199, 3256, 3288, 3383, 3461, 3529, 3691, 3734, 3904, 4113, 4170, 4295, 4307], 'inhibited': [143, 364, 2684, 3617, 4240], 'only': [144, 365, 2846, 4046, 4309], 'much': [146, 367], 'higher': [147, 368, 2897, 3021], 'Gd3+': [150, 173, 371, 394, 2531, 2596, 2683, 2712, 2733, 2836, 2874, 2921, 2997, 3064, 3084, 3113, 3239, 3554, 3590, 3616, 3635, 3725, 3969], 'unaffected': [153, 374, 4286], '2-APB.': [157, 181, 378, 402], 'Like': [158, 379, 3999], 'arachidonic': [159, 219, 380, 440, 1107, 1110, 1270, 1296, 1421, 1443, 1487, 3223, 3249, 3276, 3358, 3392, 3405, 3423, 3458, 3476, 3524, 3556, 3624, 3642, 3692, 3862, 4130, 4152, 4175, 4212, 4281], 'acid-induced': [160, 381, 1111, 1444, 3557, 3643, 4282], 'entry,': [161, 382, 4120], 'insensitive': [169, 390], 'inhibition': [171, 392, 2731, 2789, 3034, 3130, 3652, 3712, 3789, 3975, 4050, 4087, 4116, 4267], 'but': [174, 395, 2155, 2320, 2486, 4352], 'These': [182, 403, 2311, 2492, 3688, 4160], 'findings': [183, 404, 1467], 'indicate': [184, 405, 1468, 3690], 'pathway': [188, 409, 929, 1479, 3717], 'responsible': [189, 410], 'driving': [194, 415], 'cells': [199, 420, 499, 522, 1507, 1542, 1570, 1602, 1637, 1705, 1769, 1782, 1863, 1985, 2221, 2258, 2277, 2289, 2329, 2505, 2811, 3088, 3207, 3245, 3889, 4216, 4261, 4347, 4422], 'more': [201, 422, 715, 4328], 'complex': [202, 423, 716], 'than': [203, 424, 2437, 3065, 3726], 'originally': [204, 425], 'thought,': [205, 426], 'may': [207, 428, 800, 884, 3024, 4082], 'involve': [208, 429], 'neither': [209, 430], 'nor': [213, 434], 'role': [215, 436, 473, 1471, 1485, 2527], 'PLA2': [217, 438], 'acid.': [220, 441, 3250, 3863], 'endoplasmic': [444, 573, 2624, 4092], 'phospholipase': [446, 537, 1178, 1230, 1233, 3230], 'A2': [447], 'HEPES-buffered': [448, 1653], 'physiological': [449, 1654], 'saline': [450, 1655], 'solution': [451, 1656], '1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic': [452, 2060], 'acid': [453, 1108, 1164, 1220, 1271, 1297, 1422, 2046, 2049, 2061, 3262, 3277, 3339, 3359, 3393, 3406, 3443, 3469, 3477, 3525, 3603, 3625, 3663, 3693, 4131, 4153, 4176, 4213], 'An': [460], 'increase': [461, 2145, 2176, 3297], 'level': [464, 2159], 'free': [467], 'Ca2+concentration': [468], 'plays': [470], 'central': [472], 'transduction': [476], 'variety': [479, 807], 'cellular': [481, 484, 1274], 'functions,': [482], 'including': [483, 1276, 4162], 'secretion,': [485], 'muscle': [486], 'contraction,': [487], 'cell': [488, 532, 659, 738, 794, 1168, 1305, 1500, 1855, 2357, 2393, 2465, 3210], 'growth': [489], 'differentiation,': [491], 'apoptosis.': [493], 'Changes': [494, 1847], 'mammalian': [498], 'are': [500, 1423, 1850, 1951, 3059, 3066, 3389, 3470, 3709, 4183], 'mediated': [501, 3221], 'mobilization': [503, 3242], 'internal': [507, 2202], 'and/or': [510], 'In': [519, 702, 1259, 1426, 1597, 1692, 2134, 2164, 2353, 2451, 2582, 3251, 3354, 3864, 4394], 'many': [520, 657], 'nonexcitable': [521], 'neurotransmitters': [526], 'hormones': [528], 'initiated': [530], 'through': [531, 4313, 4348], 'membrane': [533, 2892, 2970, 3133, 3227, 3299, 3746], 'coupled': [535], 'C': [538, 1231], 'production': [541], '(IP3)1': [545], '(1Berridge': [546, 740, 811, 893, 997], 'M.J.': [547, 674, 741, 754, 812, 894, 998, 1082, 1867], 'Nature.': [548, 742, 813, 895, 999, 3765], '1993;': [549, 743, 814, 865, 896, 950, 1000, 1918], '361:': [550, 744, 815, 897, 1001], '315-325Crossref': [551, 745, 816, 898, 1002], 'PubMed': [552, 619, 680, 697, 746, 780, 817, 840, 857, 868, 899, 919, 953, 969, 1003, 1026, 1076, 1088, 1121, 1138, 1158, 1199, 1254, 1320, 1337, 1355, 1407, 1592, 1754, 1893, 1910, 1921, 1941, 2011, 2093, 2243, 2550, 2675, 2913, 2989, 3155, 3192, 3308, 3436, 3512, 3769, 3809, 3836, 3957, 4374], 'Scopus': [553, 620, 681, 698, 747, 781, 818, 841, 869, 900, 920, 954, 970, 1004, 1027, 1077, 1089, 1122, 1139, 1159, 1200, 1255, 1338, 1356, 1373, 1388, 1408, 1593, 1755, 1894, 1922, 1942, 2012, 2094, 2244, 2551, 2578, 2753, 2914, 3156, 3173, 3193, 3309, 3437, 3513, 3770, 3810, 3837, 3958, 4230], '(6175)': [554, 748, 819, 901, 1005], 'Google': [555, 622, 635, 683, 700, 749, 783, 820, 843, 858, 871, 902, 922, 956, 972, 1006, 1029, 1079, 1091, 1124, 1141, 1161, 1202, 1217, 1257, 1321, 1340, 1358, 1375, 1390, 1410, 1595, 1757, 1896, 1911, 1924, 1944, 2014, 2096, 2246, 2553, 2580, 2655, 2676, 2755, 2916, 2990, 3158, 3175, 3195, 3311, 3439, 3515, 3772, 3812, 3839, 3960, 4232, 4375], 'Scholar).': [556, 636, 701, 784, 872, 923, 973, 1030, 1092, 1162, 1218, 1258, 1411, 1596, 1758, 2097, 2247, 2581, 2677, 2756, 2917, 2991, 3312, 3440, 3516, 3773, 3840, 3961, 4233, 4376], 'IP3': [557, 875, 943, 1474, 3741, 3819, 4323], 'second': [560, 2422, 2460], 'messenger': [561], 'produces': [562], 'signal,': [566], 'an': [569, 1262, 2377, 2402, 2408, 2427, 2770, 3005, 3033, 3415, 3475, 4063], 'initial': [570, 2037], 'Ca2+release': [571, 3267, 3385], '(ER),': [575], 'followed': [576, 2150, 3365, 3538], 'sustained': [579, 706, 2157, 2188, 2487, 3368, 4256], 'plateau': [581], 'due': [582, 1712, 1959, 1967, 2600, 2779, 2965, 3026, 3293, 3530, 3585, 3659, 4070, 4084, 4126, 4210], 'across': [586, 3543], 'plasma': [588, 647, 2969, 3132, 3545, 3745], 'membrane.': [589, 648, 3546], 'This': [590, 637, 2440], 'usually': [593], 'results': [594, 730, 2493, 2709, 2807, 3689, 4157], 'depletion': [597], 'such': [604, 986, 2769], 'instances': [605], 'termed': [607], '"capacitative': [608], 'entry"': [610], '(2Putney': [611], 'Jr.,': [612, 625, 686, 773, 833, 1019, 1069, 1579, 1886, 2645, 2664, 2981], 'J.W.': [613, 626, 687, 774, 834, 1020, 1070, 1580, 1887, 2646, 2665, 2982], 'Cell': [614, 1083, 1116, 1153, 1212, 1350, 2006, 3150], 'Calcium.': [615, 1084, 1117, 1351, 2007, 3151], '1986;': [616], '7:': [617], '1-12Crossref': [618], '(2109)': [621], 'Scholar,': [623, 684, 750, 761, 821, 844, 859, 903, 957, 1007, 1080, 1125, 1142, 1322, 1341, 1359, 1376, 1391, 1874, 1897, 1912, 1925, 2656, 3159, 3176], '3Putney': [624], 'Capacitative': [627, 2647], 'Calcium': [628, 2648], 'Entry.': [629, 2649], 'Landes': [630, 2650], 'Biomedical': [631, 2651], 'Publishing,': [632, 2652], 'Austin,': [633, 2653], 'TX1997Crossref': [634, 2654], 'mode': [638], 'presumably': [641, 1711, 2524], 'involves': [642, 1103, 3738], 'store-operated': [643, 668, 3569], 'Ca2+channels': [644], 'Although': [649], 'has': [653, 930, 1099, 2556, 3927], 'been': [654, 931, 1100, 1299, 2210, 2557, 3928], 'documented': [655], 'different': [658, 793, 2806, 3495, 4184], 'types,': [660, 795], 'store': [665], 'emptying': [666], 'activates': [667, 4177], 'channels': [670, 3055, 4383], 'remains': [671], 'uncertain': [672], '(4Berridge': [673], 'Biochem.': [675, 1332, 2089, 3832, 3953], 'J.': [676, 755, 765, 776, 825, 836, 852, 908, 1011, 1022, 1061, 1072, 1133, 1152, 1195, 1209, 1250, 1311, 1333, 1362, 1383, 1396, 1577, 1581, 1743, 1868, 1878, 1889, 1905, 1930, 2088, 2232, 2573, 2666, 2748, 2984, 3162, 3181, 3431, 3501, 3831, 3952, 4219, 4365], '1995;': [677, 1334, 1746], '312:': [678], '1-11Crossref': [679], '(1049)': [682], '5Putney': [685], 'Cell.': [688], '1999;': [689, 1118, 1155, 1385, 2575, 2750, 3152], '99:': [690], '5-8Abstract': [691], 'Full': [692, 694, 966, 1317, 1368, 1370, 1402, 1404, 1587, 1589, 1749, 1751, 2238, 2240, 2672, 3168, 3170, 3187, 3189, 3507, 3509, 4225, 4227, 4371], 'Text': [693, 695, 967, 1318, 1369, 1371, 1403, 1405, 1588, 1590, 1750, 1752, 2239, 2241, 2673, 3169, 3171, 3188, 3190, 3508, 3510, 4226, 4228, 4372], 'PDF': [696, 968, 1319, 1372, 1406, 1591, 1753, 2242, 2674, 3172, 3191, 3511, 4229, 4373], '(126)': [699], 'addition': [703, 3677], 'elevation': [707, 3369], '[Ca2+]iseen': [709], 'high': [711, 2871, 3938], 'agonist': [712], 'concentrations,': [713, 3022], 'subtle': [718], 'cycling': [720], '[Ca2+]i,': [722], 'known': [723, 2884], 'spiking': [726], '[Ca2+]ioscillations,': [728], 'often': [729], 'agonists': [735, 892, 3219], 'some': [737, 2099], 'types': [739, 1306, 3211], '6Prince': [751], 'W.T.': [752, 1865], 'Berridge': [753, 1866], 'Exp.': [756, 1869], 'Biol.': [757, 1154, 1312, 1363, 1397, 1582, 1744, 1870, 2233, 2667, 3163, 3182, 3502, 4220, 4366], '1973;': [758, 1871], '58:': [759, 1872], '367-384Google': [760, 1873], '7Thomas': [762, 822, 1008, 1875], 'A.P.': [763, 823, 1009, 1059, 1876], 'St': [764, 824, 1010, 1060, 1576, 1877], 'Bird': [766, 826, 1012, 1062, 1879], 'G.': [767, 769, 827, 829, 1013, 1015, 1063, 1065, 1575, 1880, 1882, 3752, 3758], 'Hajnóczky': [768, 828, 1014, 1064, 1881], 'Robb-Gaspers': [770, 830, 1016, 1066, 1883], 'L.D.': [771, 831, 1017, 1067, 1884], 'Putney': [772, 832, 1018, 1068, 1578, 1885, 2663, 2980], 'FASEB.': [775, 835, 1021, 1071, 1194, 1249, 1888], '1996;': [777, 837, 1023, 1073, 1584, 1890], '10:': [778, 838, 1024, 1074, 1891], '1505-1517Crossref': [779, 839, 1025, 1075, 1892], '(422)': [782, 842, 1028, 1078, 1895], 'characteristics': [786], 'vary': [790], 'widely': [791], 'among': [792, 2338, 4012], 'single': [798, 1565, 1854], 'mechanism': [799, 1033, 1098, 1457], 'be': [801, 983, 991, 1175, 1223, 2213, 2636, 3674, 4077, 4083, 4205], 'insufficient': [802], 'account': [804, 3931], 'observed': [809, 1696, 1703, 2193], 'responses': [810, 2003, 2103, 2268, 2296, 3708, 3855], '8Tsunoda': [845, 1898], 'Y.': [846, 1150, 1899], 'Stuenkel': [847, 1900], 'E.L.': [848, 1901], 'Williams': [849, 1902], 'J.A.': [850, 1903], 'Am.': [851, 1904, 2983], 'Physiol.': [853, 864, 949, 1906, 1917, 2985], '1990;': [854, 1314, 1907, 2986], '258:': [855, 1908, 2987], 'C147-C155Crossref': [856, 1909], '9Fewtrell': [860, 1913], 'C.': [861, 946, 1148, 1206, 1347, 1914, 2352, 2901], 'Ann.': [862, 947, 1915], 'Rev.': [863, 948, 1916], '55:': [866, 951, 1919], '427-454Crossref': [867, 952, 1920], '(202)': [870, 955, 1923], 'Formation': [873], 'cyclical': [877], 'IP3-sensitive': [882], 'underlie': [885], 'generation': [887, 944, 1105], '10De': [904, 1926], 'Young': [905, 1927], 'G.W.': [906, 1928], 'Keizer': [907, 1929], 'Proc.': [909, 1931], 'Natl.': [910, 1932], 'Acad.': [911, 1933], 'Sci.': [912, 1934], 'U.': [913, 1935], 'S.': [914, 1345, 1936, 2083, 3764, 3826, 3947], 'A.': [915, 1328, 1331, 1937], '1992;': [916, 963, 1938], '89:': [917, 1939], '9895-9899Crossref': [918, 1940], '(579)': [921, 1943], 'However,': [924, 1031, 1412, 1465, 2248, 2804, 2881, 3038, 3275, 4032, 4290], 'Ca2+-induced': [926], 'suggested': [932, 1268, 3198, 3929, 4196], 'initiating': [934], 'caffeine': [937], 'other': [939, 1947, 3209], 'agents': [940], 'unrelated': [941], '(9Fewtrell': [945], '11Friel': [958], 'D.D.': [959], 'Tsien': [960], 'R.W.': [961], 'Neuron.': [962], '8:': [964], '1109-1125Abstract': [965], '(98)': [971], 'Ca2+influx': [974], 'external': [977, 3099], 'milieu': [978], 'currently': [980], 'thought': [981], 'activated': [984, 3090, 3390], 'situations': [987], 'appears': [989, 3562, 4202], 'needed': [992], 'sustain': [994], 'whereby': [1034], 'triggered': [1038], 'during': [1039, 1056, 2388, 2458, 4337], 'not': [1043, 1424, 1701, 2331, 2490, 2710, 2721, 3323, 3480, 4122, 4158, 4203], 'altogether': [1044], 'clear.': [1045, 1425], 'Some': [1046], 'models': [1047], 'suggest': [1048], 'provides': [1053], '(7Thomas': [1058], '12Berridge': [1081], '1991;': [1085, 1196, 1251], '12:': [1086], '63-72Crossref': [1087], '(142)': [1090], 'More': [1093], 'recently': [1094], 'novel,': [1096], 'noncapacitative': [1097, 1456, 2564, 3201], 'proposed': [1101], 'agonist-activated': [1104, 2537], '(13Shuttleworth': [1114, 3148], 'T.J.': [1115, 1361, 1395, 2005, 2229, 3149, 3161, 3178, 3498, 4218, 4364], '25:': [1119, 3153], '237-246Crossref': [1120, 3154], '(94)': [1123, 3157], '14Akagi': [1126], 'K.': [1127, 2087, 3748, 3802, 3830, 3951], 'Nagao': [1128], 'T.': [1129, 1131, 2079, 2081, 2085, 3754, 3822, 3824, 3828, 3943, 3945, 3949], 'Urushidani': [1130], 'Jpn.': [1132], 'Pharmacol.': [1134, 3432], '1997;': [1135, 1352, 1365, 2090, 3165, 3833, 3954, 4222], '75:': [1136], '33-42Crossref': [1137], '(21)': [1140, 1160], '15Lankisch': [1143], 'T.O.': [1144], 'Nozu': [1145], 'F.': [1146], 'Owyang': [1147], 'Tsunoda': [1149], 'Eur.': [1151, 3430], '78:': [1156], '632-641Crossref': [1157], 'present': [1166], 'membranes': [1169], 'esterified': [1170], 'phospholipids': [1172], 'can': [1174, 1221, 2889], 'released': [1176, 3225], 'A2(PLA2)': [1179], 'response': [1181, 1419, 2429, 2935, 2958, 3213, 3247, 3347, 3599, 4148, 4258, 4273], 'various': [1183], 'stimuli': [1185], '(16Dennis': [1186, 1241], 'E.A.': [1187, 1208, 1242], 'Rhee': [1188, 1243], 'S.G.': [1189, 1244], 'Billah': [1190, 1245], 'M.M.': [1191, 1246], 'Hannun': [1192, 1247], 'Y.A.': [1193, 1248], '5:': [1197, 1252], '2068-2077Crossref': [1198, 1253], '(475)': [1201, 1256], 'Scholar,17Graber': [1203], 'R.': [1204, 4362], 'Sumida': [1205], 'Nurez': [1207], 'Lipid': [1210], 'Mediat.': [1211], 'Signal.': [1213], '1994;': [1214, 2008, 2547, 3305], '9:': [1215], '91-116PubMed': [1216], 'also': [1222, 3636, 4076], 'generated': [1224], 'diacylglycerol,': [1226], 'product': [1228], 'D': [1234], 'activation,': [1235], 'action': [1237, 2926], 'diglyceride': [1239], 'lipase': [1240], 'recent': [1260], 'years,': [1261], 'increasing': [1263], 'number': [1264, 1303, 2118], 'reports': [1266, 1453], 'directly': [1272, 4329], 'modulates': [1273], 'responses,': [1275, 3410], 'transduction.': [1279], 'As': [1280, 2412, 2678, 2823, 2992, 3331, 4134, 4194, 4234], 'IP3,': [1282], 'ER': [1286, 3926], 'space': [1293], 'demonstrated': [1300], '(18Chow': [1307], 'S.C.': [1308], 'Jondal': [1309], 'M.': [1310], 'Chem.': [1313, 1364, 1398, 1583, 1745, 2234, 2668, 3164, 3183, 3503, 4221, 4367], '265:': [1315], '902-907Abstract': [1316], '19van': [1323], 'der': [1324], 'Zee': [1325], 'L.': [1326, 1343, 3762, 3800], 'Nelemans': [1327], 'Den': [1329], 'Hertog': [1330], '305:': [1335], '859-864Crossref': [1336], '(48)': [1339, 1594], '20Munaron': [1342], 'Antoniotti': [1344], 'Distasi': [1346], 'Lovisolo': [1348], 'D.': [1349, 2450], '22:': [1353], '179-188Crossref': [1354], '(62)': [1357], '21Shuttleworth': [1360, 3160], '271:': [1366, 1585, 3166, 4223], '21720-21725Abstract': [1367, 3167, 4224], '(144)': [1374, 3174, 4231], '22Broad': [1377], 'L.M.': [1378, 2568, 2743], 'Cannon': [1379, 2569, 2744], 'T.R.': [1380, 1740, 2570, 2745], 'Taylor': [1381, 2571, 2746], 'C.W.': [1382, 2572, 2747], 'Physiol.(Lond.).': [1384, 2574, 2749], '517:': [1386, 2576, 2751], '121-134Crossref': [1387, 2577, 2752], '(195)': [1389, 2579, 2754, 3310], '23Mignen': [1392], 'O.': [1393, 2662, 2979], 'Shuttleworth': [1394, 3144, 3488], '2000;': [1399, 3806], '275:': [1400], '9114-9119Abstract': [1401], '(177)': [1409], 'mechanisms': [1414, 4172], 'changes': [1417, 2370, 3464], 'this': [1427, 1477, 1499, 2168, 2354, 2389, 2452, 2478, 3560, 3716, 3779, 3847, 4049, 4288, 4296, 4318, 4417], 'study,': [1428], 'we': [1429, 1695, 1722, 2261, 2344, 3233, 3254, 3411, 3548, 4291, 4340], 'used': [1431, 1554, 1723], 'relatively': [1432, 3565], 'specific': [1433], 'pharmacological': [1434], 'probes': [1435], 'analyze': [1437], 'compare': [1439], 'capacitative,': [1440], 'noncapacitative,': [1441], 'confirm': [1451, 2494], 'earlier': [1452], 'our': [1466], 'possible': [1470, 3400], 'call': [1481], 'into': [1482], 'question': [1483], 'at': [1489, 1514, 1625, 1647, 1816, 1831, 1962, 1970, 2297, 2847, 2896, 3019, 3039, 3278, 3629, 3719, 3875, 4108, 4356], 'least': [1490, 3720], 'direct': [1493], 'mediator': [1494], 'type.': [1501], 'Human': [1502], '293': [1505], 'obtained': [1508, 2017, 2051, 2809, 4165], 'ATCC': [1511], 'were': [1512, 1543, 1561, 1603, 1638, 1700, 1783, 1829, 1978, 2050, 2063, 2107, 2259, 2278, 2489, 2606, 2759, 2808, 2812, 3089, 4423], 'grown': [1513], '37': [1515, 1626], '°C': [1516, 1627], "Dulbecco's": [1518, 1612], "Eagle's": [1519, 1613], 'medium': [1520, 1614, 1989, 2472, 3378, 3914], 'supplemented': [1521], '10%': [1523], 'heat-inactivated': [1524], 'fetal': [1525], 'bovine': [1526], 'serum': [1527], '2': [1529, 1840, 1993, 2706], 'mm': [1530, 1731, 1994, 2307, 4399], 'glutamine': [1531], 'humidified': [1534], '95%': [1535], 'air,': [1536], '5%': [1537], 'CO2incubator.': [1538], 'For': [1539, 2098], 'measurements,': [1541, 1636], 'cultured': [1544], 'about': [1546, 2284, 2361, 2381, 3885], '70%': [1547], 'confluence,': [1548], 'passaged': [1549], 'onto': [1550, 1770], 'glass': [1551], 'coverslips,': [1552], '24–48': [1555], 'h': [1556, 1841], 'after': [1557, 2376, 3372], 'plating.': [1558], 'Fluorescence': [1559, 1759], 'measurements': [1560], 'made': [1562], 'Fura2-loaded': [1564, 1768], 'groups': [1567], 'described': [1572, 1736, 2077], 'previously': [1573, 1735, 2076, 2503], '(24Bird': [1574], '6766-6770Abstract': [1586], 'brief,': [1598], 'coverslips': [1599], 'attached': [1601], 'mounted': [1604], 'Teflon': [1607, 1765], 'chamber': [1608, 1766], 'incubated': [1610, 1643], 'acetoxymethyl': [1618], 'ester': [1619], 'Fura2': [1621, 1957, 4354], '(Fura2/AM,': [1622], 'Molecular': [1623], 'Probes)': [1624], 'dark': [1630], '25': [1632, 2382], 'min.': [1633], 'Before': [1634], 'washed': [1639], 'three': [1640, 2369], 'times': [1641], '30': [1645, 3000, 3115, 3258, 3337, 3456, 3467, 3601, 3622, 3661, 4017, 4033, 4128, 4150], 'min': [1646, 2383, 2455], 'room': [1648, 1832], 'temperature': [1649, 1833], '(25': [1650, 1834], '°C)': [1651, 1835], '(HPSS:': [1657], 'NaCl,': [1658], '120': [1659], 'mm;': [1660, 1663, 1666, 1669, 1672, 1676], 'KCl,': [1661], '5.4': [1662], 'Mg2SO4,': [1664], '0.8': [1665], 'HEPES,': [1667], '20': [1668, 2362, 2404, 3441], 'CaCl2,': [1670], '1.8': [1671], 'glucose,': [1674], '10': [1675, 3040, 3320, 3614, 3630, 3633, 3654], 'pH': [1678], '7.4': [1679], 'adjusted': [1680], 'NaOH).': [1682], 'Ca2+-free': [1683, 1988, 2166, 2471, 3356, 3666, 3913, 4403], 'solutions': [1684], 'contained': [1685], 'no': [1686, 2697, 2714, 2840, 3044, 3445, 3592], 'added': [1687], 'CaCl2': [1688, 1733], 'HPSS.': [1691], 'preliminary': [1693, 3252], 'experiments,': [1694, 2100, 3253, 3970], 'reproducibly': [1702, 3264], 'loaded': [1706], 'Fura2/AM,': [1710], 'excessive': [1714], 'buffering.': [1717], 'Thus,': [1718, 3018, 3232, 3547, 4377], 'experiments': [1721, 1828, 1858, 1977, 2583, 2758], 'nm': [1725, 1790, 1818, 1964, 1972], 'Fura2/AM': [1726], 'loading': [1728, 1843], '1.5': [1730, 2306], '(25Wayman': [1737], 'G.A.': [1738], 'Hinds': [1739], 'Storm': [1741], 'D.R.': [1742, 3427], '270:': [1747], '24108-24115Abstract': [1748], '(43)': [1756], 'monitored': [1761], 'placing': [1763], 'stage': [1772], 'Nikon': [1775], 'Diaphot': [1776], 'microscope': [1777], '(40×': [1778], 'Neofluor': [1779], 'objective).': [1780], 'excited': [1784], 'alternatively': [1785], '340': [1787, 1963, 2026], '380': [1789, 1971, 2028], 'wavelength': [1791], 'light': [1792, 1801, 1806], 'Deltascan': [1795], 'D101': [1796], '(Photon': [1797], 'Technology': [1798], 'International': [1799], 'Ltd.,)': [1800], 'source': [1802], 'equipped': [1803], 'path': [1807], 'chopper': [1808], 'dual': [1810], 'excitation': [1811, 1961, 1969], 'monochromators.': [1812], 'Emission': [1813], 'fluorescence': [1814, 1958, 2024, 3343, 3882, 4355], 'intensity': [1815], '510': [1817], 'recorded': [1820], 'photomultiplier': [1823], 'tube': [1824], '(Omega': [1825], 'Optical).': [1826], 'All': [1827], 'conducted': [1830], 'carried': [1837, 2760], 'out': [1838, 2761], 'within': [1839], 'each': [1845], 'coverslip.': [1846], 'reported': [1851, 2211, 2738, 4385], 'one': [1853, 2482], 'oscillation': [1857], 'group': [1861, 1982], '(6Prince': [1864], 'Scholar)': [1945, 2554, 3196], 'protocols.': [1948], 'data': [1950, 4164], 'expressed': [1952, 2031, 2110], 'ratio': [1955, 3883], '(F': [1973, 2104], '340/F': [1974, 2105, 2148], '380).': [1975], 'Mn2+quench': [1976], 'performed': [1979], 'nominally': [1987, 2165, 2470, 3355, 3665, 3912, 4402], 'containing': [1990, 2473], '0.1': [1991, 4398], 'MnCl2.': [1995], 'F': [1996], 'tot,': [1997], 'independent': [2000], '(26Shuttleworth': [2004], '15:': [2009], '457-466Crossref': [2010], '(29)': [2013], 'Scholar),': [2015, 3813], 'weighted': [2020], 'summing': [2021], 'nm,': [2029], 'percentage': [2034], 'value': [2038], 'absence': [2041, 2940, 3097, 3870], 'Mn2+.': [2044], '5,8,11,14-eicosatetraenoic': [2048, 3413], 'BioMol': [2053], '(Plymouth': [2054], 'Meeting,': [2055], 'PA).': [2056], 'Carbachol,': [2057], '(BAPTA)': [2062], 'purchased': [2064], 'Calbiochem': [2066], '(La': [2067], 'Jolla,': [2068], 'CA).': [2069], '2-Aminoethyoxydiphenyl': [2070], '(2-APB)': [2072], 'synthesized': [2074], '(27Maruyama': [2078, 3821, 3942], 'Kanaji': [2080, 3823, 3944], 'Nakade': [2082, 3825, 3946], 'Kanno': [2084, 3827, 3948], 'Mikoshiba': [2086, 3801, 3829, 3950], '122:': [2091, 3834, 3955], '498-505Crossref': [2092, 3835, 3956], '(774)': [2095, 3838, 3959], 'average': [2101], 'peak': [2102, 4040], '380)': [2106, 2149], 'calculated': [2108], 'mean': [2112], '±': [2113, 3901], 'S.E.': [2114], 'indicated': [2117, 3107, 3733], '(n)': [2119], 'experiments.': [2121], 'Statistical': [2122], 'significance': [2123], 'determined': [2125, 2919], "Student's": [2128], 't': [2129], 'test': [2130], '(p': [2131], '<': [2132], '0.05).': [2133], 'Ca2+-containing': [2135], 'HPSS,': [2136, 2420], 'large,': [2142], 'somewhat': [2143, 2337, 2435, 3494], 'transient': [2144, 2175, 2267, 3362, 4243], '[Ca2+]i(F': [2147], 'slowly': [2153, 3340], 'declining': [2154], 'generally': [2156, 2406], 'elevated': [2158], '(Fig.1': [2162, 2309], 'A).': [2163, 4430], 'medium,': [2167, 2185, 2373, 3357, 3667, 4404], 'same': [2169, 2392, 2586, 4010], '[Ca2+]i;': [2178], 'following': [2179], 're-addition': [2180], 'second,': [2187], '(Fig.': [2194, 2705, 3379, 3604, 3646, 3989, 4079, 4132, 4154], 'B),': [2196, 3381], 'indicating': [2197, 2525, 3050, 3126, 3382, 3460], 'sites': [2203], 'transfected': [2222, 2506], 'M3': [2225, 2509], '(28Shuttleworth': [2228, 3497], 'Thompson': [2230, 3179, 3490, 3499], 'J.L.': [2231, 3180, 3500], '1998;': [2235, 3184, 3433, 3504, 3766], '273:': [2236, 3185, 3505], '32636-32643Abstract': [2237, 3186, 3506], '(78)': [2245, 3194, 3514], 'current': [2251], 'study': [2252], 'wild': [2255, 2497], 'type': [2256, 2498], 'used,': [2260], 'failed': [2262], 'consistently': [2264], 'produce': [2265], '1–3': [2272], 'carbachol.': [2274, 2822, 4193, 4265], 'When': [2275], 'stimulated': [2279, 2359, 2396, 2813], '5': [2281, 2398, 2454, 2819, 3318, 3335, 3380, 4263, 4275, 4431], 'carbachol,': [2283, 2463, 2767], '50%': [2285], 'tested': [2288, 3890], '(101': [2290], '205)': [2292], 'showed': [2293], 'oscillatory': [2294, 2428, 2863, 4257], 'frequency': [2299, 2322, 2335], '∼0.5–1/min': [2301], 'presence': [2304, 2947, 3104, 4396, 4444], 'C).': [2310, 3608, 3649], 'robust': [2312], 'could': [2314, 3263, 3673, 4075], 'last': [2315], 'up': [2316], 'h,': [2319], 'progressively': [2323], 'slowed': [2324], 'time.': [2326], 'Because': [2327], 'all': [2328, 3329, 4357], 'did': [2330, 2342, 3322, 4121], 'oscillate': [2332, 2815], 'varied': [2336], 'oscillate,': [2343], 'adopted': [2345], 'protocol': [2347, 2441, 2587, 3965], 'shown': [2348, 2413, 2502, 2558, 2679, 2773, 2993, 3332, 4235], 'Fig.': [2350, 2415, 2590, 2824, 2995, 3334, 4237], 'protocol,': [2355, 2479], 'min,': [2363, 2405], 'removed': [2367], 'incubation': [2372], 'then,': [2375], 'additional': [2378, 2403], 'period': [2379], '(data': [2384, 2720, 3479], 'acquisition': [2385], 'halted': [2387], 'period),': [2390], 'again': [2395, 4437], 'under': [2407, 2961], 'altered': [2409, 4002], 'experimental': [2410], 'condition.': [2411], 'C,': [2417], 'normal': [2419, 3669], 'stimulation': [2423], 'always': [2424], 'resulted': [2425, 3284], 'similar': [2432, 2735, 2925, 3483, 3964], 'to,': [2433], 'although': [2434], 'slower': [2436], 'first.': [2439], 'utilized': [2443, 4341], 'experiment': [2446, 2771], 'illustrated': [2447], 'Fig.1': [2449], 'experiment,': [2453], 'before,': [2456], 'exposure': [2461], 'bathed': [2467], '200': [2474], 'BAPTA.': [2476], 'With': [2477, 4059], 'two': [2484, 3352, 4014], 'spikes,': [2485], 'observed.': [2491], 'that,': [2495], 'receptor,': [2511], '[Ca2+]ioscillations': [2512], 'produced': [2513, 2837, 3972], 'low': [2516, 3215], 'depend': [2520, 4320], 'Ca2+,': [2523, 3031, 3873], 'influx.': [2530], 'potent': [2534], 'inhibitor': [2535, 3416, 3816, 3852], '(29Fernando': [2540], 'K.C.': [2541], 'Barritt': [2542], 'G.J.': [2543], 'Biochim.': [2544], 'Biophys.': [2545], 'Acta.': [2546], '1222:': [2548], '383-389Crossref': [2549], '(33)': [2552], 'discriminate': [2560], 'between': [2561, 3257, 3740], '(22Broad': [2567], 'utilizing': [2584, 2762], 'B,': [2592], 'effects': [2594, 3237, 3552, 3567], 'SERCA': [2603, 2620], 'determined.': [2607], 'Thapsigargin': [2608], 'depletes': [2609], 'Ca2+stores': [2610], 'passively': [2611], 'virtue': [2613], 'its': [2615, 3016], 'ability': [2616], 'inhibit': [2618, 2890], 'pumps': [2621], 'reticulum,': [2625], 'ensuing': [2628], 'therefore': [2633], 'assumed': [2634], 'very': [2638, 2870], 'definition': [2639], '(3Putney': [2644], '30Takemura': [2657], 'H.': [2658, 2975, 3302], 'Hughes': [2659], 'A.R.': [2660], 'Thastrup': [2661, 2978], '1989;': [2669, 4368], '264:': [2670, 4369], '12266-12271Abstract': [2671], 'Fig.2': [2681, 2775], 'A,': [2682, 3336], 'thapsigargin': [2690, 2937, 2960, 3124, 3681, 4074, 4191], 'concentration-dependent': [2693, 3273, 3974, 4247], 'manner,': [2694], 'significant': [2698, 2715, 3045, 3593], 'effect': [2699, 2716, 2841, 3446, 3594, 3921], 'phase': [2704, 4006], 'shown).': [2711, 2722, 3481, 3687, 4159], 'had': [2713, 3444, 3591], 'basal': [2718], 'sensitivity': [2724, 3783], 'thapsigargin-induced': [2726, 3009], 'Broad': [2740], 'et': [2741], 'al.(22Broad': [2742], 'Similar': [2757], 'B.': [2776, 2903], 'activation': [2784, 3540], 'appeared': [2785, 3348], 'similarly': [2786], 'sensitive': [2787, 3062, 3710, 3723, 4104], 'Gd3+,': [2791, 4000, 4167], 'leading': [2792], 'conclusion': [2795, 3484], 'largely': [2800], 'entirely': [2802, 2967], 'capacitative.': [2803], 'significantly': [2805], 'when': [2810, 3992, 4311, 4420], 'lower,': [2818], 'μmconcentration': [2820], '3': [2825, 3612], 'illustrates,': [2826], '1,': [2829], '10,': [2830], '30,': [2831], '100,': [2832], '500': [2834, 2854], 'little': [2838], 'oscillations;': [2845], 'highest': [2849], 'tested,': [2851], 'there': [2857, 3042], 'even': [2858, 2868], 'partial': [2859, 4096], 'suppression': [2860], 'frequency.': [2864], 'failure': [2866], 'block': [2876, 4023], 'surprising.': [2880], 'it': [2882], 'another': [2886], 'lanthanide,': [2887], 'La3+,': [2888], 'active': [2891], 'extrusion': [2893, 2971, 3075], '(31Van': [2899], 'Breemen': [2900], 'Farinas': [2902], 'Gerba': [2904], 'P.': [2905], 'McNaughton': [2906], 'E.D.': [2907], 'Circ.': [2908], 'Res.': [2909], '1972;': [2910], '30:': [2911], '44-54Crossref': [2912], '(362)': [2915], 'whether': [2920], 'might': [2922, 4300, 4319], 'examining': [2928], 'time': [2930], 'course': [2931], 'varying': [2949], 'Gd3+.': [2952, 3110], 'decay': [2954, 3121], 'conditions': [2963], 'almost': [2966, 4008], '(32Kwan': [2972], 'C.Y.': [2973], 'Takemura': [2974], 'Obie': [2976], 'J.F.': [2977], 'C1006-C1015Crossref': [2988], '4,': [2996], 'greater': [3003, 3118], 'caused': [3004, 3637, 4114, 4140], 'augmentation': [3006, 3046], 'slowing': [3014], 'decay.': [3017], 'continue': [3025], '"trapping"': [3028], 'despite': [3032], 'response,': [3049], 'supporting': [3056], 'truly': [3060], 'less': [3061, 3722], 'channels.Figure': [3070], '4Effects': [3071], 'Gd3+on': [3073], 'To': [3079, 3397], 'assess': [3080, 4327], 'inhibitory': [3081, 3920], 'actions': [3082, 3845, 4331], 'extrusion,': [3087], 'μmthapsigargin': [3093, 3910, 3988], '(TG)': [3094], 'Concentrations': [3111, 3313], 'delayed': [3119], 'transient,': [3125], 'degree': [3128], 'extrusion.View': [3135], 'Large': [3136], 'Image': [3137], 'Figure': [3138], 'ViewerDownload': [3139], 'Hi-res': [3140], 'image': [3141], 'Download': [3142], '(PPT)': [3143], 'his': [3146], 'coworkers': [3147], '28Shuttleworth': [3177], 'occurring': [3204], 'lipids': [3228], 'A2.': [3231], 'next': [3234, 3549, 3842], 'examined': [3235, 3550, 3843], 'found': [3255], '300': [3260], 'μmarachidonic': [3261, 3338, 3468, 3602, 3662], 'induce': [3265, 3324, 4301], 'both': [3266, 3384, 3695, 3705, 4028], 'manner.': [3274], '>': [3280], 'occasionally': [3283], 'levels': [3287], 'saturated': [3289], 'indicator': [3291], 'likely': [3292], 'nonselective': [3296], 'permeability': [3300], '(33Meves': [3301], 'Prog.': [3303], 'Neurobiol.': [3304], '43:': [3306], '175-186Crossref': [3307], 'range': [3316], 'increases': [3325], 'increased': [3341, 4433], 'ratio,': [3344], 'occur': [3350], 'phases.': [3353], 'restoration': [3373], 'examine': [3398], 'involvement': [3401], 'metabolites': [3403], 'employed': [3412], 'cyclooxygenase,': [3418], 'lipoxygenases,': [3419], 'cytochrome': [3421], 'P450': [3422], 'acid-metabolizing': [3424], 'enzymes': [3425], '(34Collins': [3426], 'Davies': [3428], 'S.N.': [3429], '342:': [3434], '213-216Crossref': [3435], '(4)': [3438], 'μm5,8,11,14-eicosatetraenoic': [3442], 'either': [3448], 'unlikely': [3471], 'result': [3473], 'metabolite': [3478], 'reached': [3486], 'based': [3491], 'strategy': [3496], 'pattern': [3518], 'reminiscent': [3527], 'thapsigargin;': [3532], 'stored': [3536], 'Ca2+entry': [3542, 3854], 'signaling,': [3558], 'because': [3559, 4280], 'lanthanide': [3561], 'selective': [3566], 'At': [3574, 3609], 'μm,': [3579, 3615, 4110], '5,': [3605, 3647], 'B': [3606], 'complete': [3627, 3639, 3651, 4022, 4115], 'blockade': [3628], 'μm.': [3631], 'Surprisingly,': [3632], 'abolishment': [3640], 'Band': [3648], 'After': [3650], 'μmGd3+': [3655], 'evoked': [3675], '(not': [3686], 'induces': [3694], 'Gd3+;': [3714], 'however,': [3715], '10-fold': [3721], 'Recent': [3730], 'studies': [3731], 'interactions': [3739], '(35Kiselyov': [3747], 'Xu': [3749], 'X.': [3750, 3760], 'Mozhayeva': [3751], 'Kuo': [3753], 'Pessah': [3755], 'I.': [3756], 'Mignery': [3757], 'Zhu': [3759], 'Birnbaumer': [3761, 3799], 'Muallem': [3763], '396:': [3767], '478-482Crossref': [3768], '(561)': [3771], 'One': [3774], 'piece': [3775], 'evidence': [3777, 4169], 'idea': [3780], '2-APB': [3791, 3874, 3941, 3971, 4001, 4019, 4035, 4057, 4107, 4139, 4239, 4252, 4269, 4333, 4428], '(36Ma': [3792], 'H.-T.': [3793], 'Patterson': [3794], 'R.L.': [3795], 'van': [3796], 'Rossum': [3797], 'D.B.': [3798], 'Gill': [3803], 'D.L.': [3804], 'Science.': [3805], '287:': [3807], '1647-1651Crossref': [3808], '(533)': [3811], 'reagent': [3848], 'potential': [3851], 'agonists,': [3857, 4015], 'unstimulated': [3865, 4414], 'slightly': [3878], 'augmented': [3879], 'baseline': [3881, 3898], '80%': [3886], '(n': [3891, 3915], '=': [3892, 3916], '48).': [3893], 'increment': [3895], '8.6': [3900], '3.2%': [3902], '9).': [3917], 'weak': [3919], 'Ca2+-ATPase': [3923, 4089], 'Utilizing': [3962], '(Fig.6,': [3984], 'top)': [3985], '6,': [3990], 'bottom)': [3991], 'restored': [3995], 'bath.': [3998], 'potency': [4011], 'producing': [4020], 'essentially': [4021], 'modes': [4029], 'activation.': [4031], 'attenuated': [4036], 'weakly,': [4047], 'still': [4052], 'incomplete': [4053], '(Fig.6).': [4058], '2-APB,': [4062], 'approximate': [4064], '20%': [4065], 'reduction': [4066, 4097, 4143], 'seen': [4078, 4412], '6),': [4080], 'size': [4100], 'pool': [4103], 'thapsigargin.': [4106], 'alter': [4123], '7).': [4133], 'slight': [4142], '7': [4155], 'data,': [4161], 'provide': [4168], 'those': [4186], 'store-depleting': [4189], 'agents,': [4190], 'first': [4195], 'Shuttleworth,': [4198], 'involved': [4206], '(21Shuttleworth': [4217], '8,': [4238], '[Ca2+]iresponses': [4244], 'manner': [4248], 'unexpected,': [4279], 'drug.': [4289], 'considered': [4292], 'possibility': [4294], 'small': [4303], 'detectable': [4310], 'amplified': [4312], 'calcium-induced': [4314], 'release,': [4316], 'functional': [4322], 'receptors.': [4324], 'Therefore,': [4325], 'Mn2+': [4342, 4345, 4390, 4409, 4434], 'quench': [4343, 4391, 4410, 4441], 'measurements.': [4344], 'enters': [4346], 'divalent': [4349], 'cation': [4350], 'channels,': [4351], 'quenches': [4353], 'wavelengths': [4358], '(37Merritt': [4359], 'J.E.': [4360], 'Jacob': [4361], 'Hallam': [4363], '1522-1527Abstract': [4370], 'activity': [4379], 'rate': [4388, 4407, 4439], 'Fura2.': [4393], 'Mn2+,': [4400], 'resting': [4406], 'pretreated': [4424], '(Fig.9': [4429], 'μmcarbachol': [4432], 'quench,': [4435], 'blocke': [4449]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993886090', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-15T20:29:21.689882', 'created_date': '2016-06-24'}
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