Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

Name: Work Video:
Duration: 3 min 30 s
Joshua N. Finger; John D. Lich; Lauren Dare; Michael N. Cook; Kristin K. Brown; Chaya Duraiswami; John Bertin; Peter J. Gough
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'polymorphisms': [31, 94], 'alternative': [33, 96], 'mRNA': [34, 97], 'splicing.Conclusion:': [35], 'cleavage': [37, 101], 'a': [39, 103], 'key': [40, 104], 'regulator': [41, 105], 'inflammasome': [45, 109, 140], 'downstream': [47, 111], 'production.Significance:': [49], 'Understanding': [50, 115], 'mechanisms': [52, 117], 'underlying': [53, 118], 'activation': [55, 120], 'required': [57, 122, 137], 'develop': [59, 124], 'effective': [60, 125], 'therapeutics.': [61, 126], 'diseases.': [79], 'Results:': [80], 'splicing.': [98], 'Conclusion:': [99], 'production.': [113], 'Significance:': [114], 'function': [131], 'find': [133], 'domain': [134], '(FIIND)': [135], 'for': [138], 'activity.Journal': [141], 'Biological': [143], 'ChemistryVol.': [144], '287Issue': [145], '37PreviewVOLUME': [146], '287': [147], '(2012)': [148], 'PAGES': [149], '25030–25037': [150], 'Full-Text': [151], 'PDF': [152], 'Open': [153], 'Access': [154]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993808715', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 28}, {'year': 2022, 'cited_by_count': 32}, {'year': 2021, 'cited_by_count': 21}, {'year': 2020, 'cited_by_count': 32}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 11}, {'year': 2013, 'cited_by_count': 14}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-23T20:36:02.908361', 'created_date': '2016-06-24'}
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