Publication Information

{'id': 'https://openalex.org/W1993471526', 'doi': 'https://doi.org/10.1172/jci39680', 'title': 'A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus', 'display_name': 'A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus', 'publication_year': 2009, 'publication_date': '2009-09-02', 'ids': {'openalex': 'https://openalex.org/W1993471526', 'doi': 'https://doi.org/10.1172/jci39680', 'mag': '1993471526', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19729836', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2752083'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci39680', 'pdf_url': 'http://www.jci.org/articles/view/39680/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/39680/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110860811', 'display_name': 'Jian Hua Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jian Hua Li', 'raw_affiliation_strings': ['Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases,NIH, Bethesda, Maryland, USA.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases,NIH, Bethesda, Maryland, USA.', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010454251', 'display_name': 'Chung‐Lin Chou', 'orcid': 'https://orcid.org/0000-0002-4878-9501'}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chung-Lin Chou', 'raw_affiliation_strings': ['Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute,'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute,', 'institution_ids': ['https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100374387', 'display_name': 'Bo Li', 'orcid': 'https://orcid.org/0000-0002-0154-3088'}, 'institutions': [{'id': 'https://openalex.org/I4210090567', 'display_name': 'National Institute of Diabetes and Digestive and Kidney Diseases', 'ror': 'https://ror.org/00adh9b73', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090567']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bo Li', 'raw_affiliation_strings': ['Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases,'], 'affiliations': [{'raw_affiliation_string': 'Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases,', 'institution_ids': ['https://openalex.org/I4210090567']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101557961', 'display_name': 'Oksana Gavrilova', 'orcid': 'https://orcid.org/0000-0002-9310-1198'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Oksana Gavrilova', 'raw_affiliation_strings': ['Mouse Metabolic Core Facility and'], 'affiliations': [{'raw_affiliation_string': 'Mouse Metabolic Core Facility and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113922738', 'display_name': 'Christoph Eisner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210090567', 'display_name': 'National Institute of Diabetes and Digestive and Kidney Diseases', 'ror': 'https://ror.org/00adh9b73', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090567']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christoph Eisner', 'raw_affiliation_strings': ['Renal Function and Injury Section, National Institute of Diabetes and Digestive and Kidney Diseases,'], 'affiliations': [{'raw_affiliation_string': 'Renal Function and Injury Section, National Institute of Diabetes and Digestive and Kidney Diseases,', 'institution_ids': ['https://openalex.org/I4210090567']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067640397', 'display_name': 'Jürgen Schnermann', 'orcid': 'https://orcid.org/0000-0002-7405-3645'}, 'institutions': [{'id': 'https://openalex.org/I4210090567', 'display_name': 'National Institute of Diabetes and Digestive and Kidney Diseases', 'ror': 'https://ror.org/00adh9b73', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090567']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jürgen Schnermann', 'raw_affiliation_strings': ['Renal Function and Injury Section, National Institute of Diabetes and Digestive and Kidney Diseases,'], 'affiliations': [{'raw_affiliation_string': 'Renal Function and Injury Section, National Institute of Diabetes and Digestive and Kidney Diseases,', 'institution_ids': ['https://openalex.org/I4210090567']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038081351', 'display_name': 'Stasia A. Anderson', 'orcid': 'https://orcid.org/0000-0002-2566-6947'}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stasia A. Anderson', 'raw_affiliation_strings': ['Animal MRI/Imaging Core, National Heart, Lung, and Blood Institute, and'], 'affiliations': [{'raw_affiliation_string': 'Animal MRI/Imaging Core, National Heart, Lung, and Blood Institute, and', 'institution_ids': ['https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050911555', 'display_name': 'Chu‐Xia Deng', 'orcid': 'https://orcid.org/0000-0001-8033-3902'}, 'institutions': [{'id': 'https://openalex.org/I4210090567', 'display_name': 'National Institute of Diabetes and Digestive and Kidney Diseases', 'ror': 'https://ror.org/00adh9b73', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090567']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chu-Xia Deng', 'raw_affiliation_strings': ['Mammalian Genetics Section, Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.'], 'affiliations': [{'raw_affiliation_string': 'Mammalian Genetics Section, Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA.', 'institution_ids': ['https://openalex.org/I4210090567']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029048638', 'display_name': 'Mark A. Knepper', 'orcid': 'https://orcid.org/0000-0002-2276-8091'}, 'institutions': [{'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mark A. Knepper', 'raw_affiliation_strings': ['Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute,'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute,', 'institution_ids': ['https://openalex.org/I4210106489']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5015095365', 'display_name': 'Jürgen Wess', 'orcid': 'https://orcid.org/0000-0003-0818-1232'}, 'institutions': [{'id': 'https://openalex.org/I4210090567', 'display_name': 'National Institute of Diabetes and Digestive and Kidney Diseases', 'ror': 'https://ror.org/00adh9b73', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090567']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jürgen Wess', 'raw_affiliation_strings': ['Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases,'], 'affiliations': [{'raw_affiliation_string': 'Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases,', 'institution_ids': ['https://openalex.org/I4210090567']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.392, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 107, 'citation_normalized_percentile': {'value': 0.918299, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '119', 'issue': '10', 'first_page': '3115', 'last_page': '3126'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10724', 'display_name': 'Ion Transport and Channel Regulation', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11967', 'display_name': 'Electrolyte and hormonal disorders', 'score': 0.9967, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10493', 'display_name': 'Ion channel regulation and function', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nephrogenic-diabetes-insipidus', 'display_name': 'Nephrogenic diabetes insipidus', 'score': 0.86726683}, {'id': 'https://openalex.org/keywords/polydipsia', 'display_name': 'Polydipsia', 'score': 0.610636}, {'id': 'https://openalex.org/keywords/polyuria', 'display_name': 'Polyuria', 'score': 0.5902818}, {'id': 'https://openalex.org/keywords/aquaporin-2', 'display_name': 'Aquaporin 2', 'score': 0.48968342}], 'concepts': [{'id': 'https://openalex.org/C2777464133', 'wikidata': 'https://www.wikidata.org/wiki/Q2892779', 'display_name': 'Nephrogenic diabetes insipidus', 'level': 3, 'score': 0.86726683}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.7496509}, {'id': 'https://openalex.org/C20352681', 'wikidata': 'https://www.wikidata.org/wiki/Q14890035', 'display_name': 'Arginine vasopressin receptor 2', 'level': 4, 'score': 0.7028966}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6876947}, {'id': 'https://openalex.org/C2779624480', 'wikidata': 'https://www.wikidata.org/wiki/Q635195', 'display_name': 'Polydipsia', 'level': 3, 'score': 0.610636}, {'id': 'https://openalex.org/C2780180277', 'wikidata': 'https://www.wikidata.org/wiki/Q1124286', 'display_name': 'Polyuria', 'level': 3, 'score': 0.5902818}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.55201644}, {'id': 'https://openalex.org/C2776958162', 'wikidata': 'https://www.wikidata.org/wiki/Q220551', 'display_name': 'Diabetes insipidus', 'level': 2, 'score': 0.54579383}, {'id': 'https://openalex.org/C2776370428', 'wikidata': 'https://www.wikidata.org/wiki/Q21124841', 'display_name': 'Vasopressin', 'level': 2, 'score': 0.5144751}, {'id': 'https://openalex.org/C85562759', 'wikidata': 'https://www.wikidata.org/wiki/Q14902527', 'display_name': 'Aquaporin 2', 'level': 4, 'score': 0.48968342}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.46275613}, {'id': 'https://openalex.org/C90474776', 'wikidata': 'https://www.wikidata.org/wiki/Q24784390', 'display_name': 'Vasopressin receptor', 'level': 4, 'score': 0.45104763}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.41225907}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.32243538}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.23580164}, {'id': 'https://openalex.org/C2775845273', 'wikidata': 'https://www.wikidata.org/wiki/Q7973466', 'display_name': 'Water channel', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C78519656', 'wikidata': 'https://www.wikidata.org/wiki/Q101333', 'display_name': 'Mechanical engineering', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C201289731', 'wikidata': 'https://www.wikidata.org/wiki/Q1172599', 'display_name': 'Inlet', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C2776885963', 'wikidata': 'https://www.wikidata.org/wiki/Q245204', 'display_name': 'Antagonist', 'level': 3, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D018500', 'descriptor_name': 'Diabetes Insipidus, Nephrogenic', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018500', 'descriptor_name': 'Diabetes Insipidus, Nephrogenic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D040181', 'descriptor_name': 'Genetic Diseases, X-Linked', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008738', 'descriptor_name': 'Methyl Ethers', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D018078', 'descriptor_name': 'Receptors, Prostaglandin E', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018078', 'descriptor_name': 'Receptors, Prostaglandin E', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051399', 'descriptor_name': 'Aquaporin 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051399', 'descriptor_name': 'Aquaporin 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051400', 'descriptor_name': 'Aquaporin 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051400', 'descriptor_name': 'Aquaporin 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018500', 'descriptor_name': 'Diabetes Insipidus, Nephrogenic', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D018500', 'descriptor_name': 'Diabetes Insipidus, Nephrogenic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D018500', 'descriptor_name': 'Diabetes Insipidus, Nephrogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017353', 'descriptor_name': 'Gene Deletion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040181', 'descriptor_name': 'Genetic Diseases, X-Linked', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D040181', 'descriptor_name': 'Genetic Diseases, X-Linked', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D040181', 'descriptor_name': 'Genetic Diseases, X-Linked', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D040181', 'descriptor_name': 'Genetic Diseases, X-Linked', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007671', 'descriptor_name': 'Kidney Concentrating Ability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007685', 'descriptor_name': 'Kidney Tubules, Collecting', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007685', 'descriptor_name': 'Kidney Tubules, Collecting', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D007685', 'descriptor_name': 'Kidney Tubules, Collecting', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008738', 'descriptor_name': 'Methyl Ethers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018078', 'descriptor_name': 'Receptors, Prostaglandin E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058309', 'descriptor_name': 'Receptors, Prostaglandin E, EP4 Subtype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017483', 'descriptor_name': 'Receptors, Vasopressin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017483', 'descriptor_name': 'Receptors, Vasopressin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017483', 'descriptor_name': 'Receptors, Vasopressin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci39680', 'pdf_url': 'http://www.jci.org/articles/view/39680/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2752083', 'pdf_url': 'https://europepmc.org/articles/pmc2752083?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752083', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19729836', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci39680', 'pdf_url': 'http://www.jci.org/articles/view/39680/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.85, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W125661582', 'https://openalex.org/W1523553171', 'https://openalex.org/W1564058944', 'https://openalex.org/W1766079894', 'https://openalex.org/W1937829052', 'https://openalex.org/W1974003680', 'https://openalex.org/W1974228630', 'https://openalex.org/W1974504971', 'https://openalex.org/W1983587440', 'https://openalex.org/W1984348241', 'https://openalex.org/W1985535077', 'https://openalex.org/W1995624094', 'https://openalex.org/W2000112317', 'https://openalex.org/W2006101768', 'https://openalex.org/W2018779154', 'https://openalex.org/W2033646259', 'https://openalex.org/W2037078439', 'https://openalex.org/W2040480751', 'https://openalex.org/W2042742511', 'https://openalex.org/W2048282656', 'https://openalex.org/W2054240817', 'https://openalex.org/W2058172887', 'https://openalex.org/W2060029591', 'https://openalex.org/W2067919854', 'https://openalex.org/W2073185619', 'https://openalex.org/W2092754551', 'https://openalex.org/W2094123176', 'https://openalex.org/W2097548343', 'https://openalex.org/W2098754254', 'https://openalex.org/W2104075229', 'https://openalex.org/W2110391758', 'https://openalex.org/W2111864962', 'https://openalex.org/W2115293226', 'https://openalex.org/W2116592798', 'https://openalex.org/W2119865824', 'https://openalex.org/W2123974943', 'https://openalex.org/W2128870011', 'https://openalex.org/W2132778679', 'https://openalex.org/W2135900087', 'https://openalex.org/W2142503533', 'https://openalex.org/W2148984043', 'https://openalex.org/W2151014103', 'https://openalex.org/W2162082543', 'https://openalex.org/W2167347790', 'https://openalex.org/W2173642814', 'https://openalex.org/W2186546695', 'https://openalex.org/W2188895203', 'https://openalex.org/W2200843121', 'https://openalex.org/W2396857638', 'https://openalex.org/W2416743722', 'https://openalex.org/W4240164957', 'https://openalex.org/W4253149290'], 'related_works': ['https://openalex.org/W3203915611', 'https://openalex.org/W3085007798', 'https://openalex.org/W3031994492', 'https://openalex.org/W2792193215', 'https://openalex.org/W2767522606', 'https://openalex.org/W2614633882', 'https://openalex.org/W2158265710', 'https://openalex.org/W2015969629', 'https://openalex.org/W1994614344', 'https://openalex.org/W1973117335'], 'abstract_inverted_index': {'X-linked': [0], 'nephrogenic': [1], 'diabetes': [2], 'insipidus': [3], '(XNDI)': [4], 'is': [5], 'a': [6, 154, 178], 'severe': [7], 'kidney': [8], 'disease': [9], 'caused': [10], 'by': [11, 77], 'inactivating': [12], 'mutations': [13], 'in': [14, 23, 66, 88, 140, 168], 'the': [15, 24, 43, 56, 68, 83, 115, 134, 150, 192, 195, 208], 'V2': [16], 'vasopressin': [17], 'receptor': [18, 157], '(V2R)': [19], 'gene': [20, 70], 'that': [21, 97, 124], 'result': [22], 'loss': [25], 'of': [26, 45, 61, 79, 85, 107, 118, 126, 136, 149, 164, 194, 211], 'renal': [27, 127, 137, 169], 'urine-concentrating': [28], 'ability.': [29], 'At': [30], 'present,no': [31], 'specific': [32], 'pharmacological': [33], 'therapy': [34], 'has': [35], 'been': [36], 'developed': [37], 'for': [38, 133, 201, 207], 'XNDI,': [39, 62, 108, 165], 'primarily': [40], 'due': [41, 176], 'to': [42, 54, 114, 177], 'lack': [44, 84, 135], 'suitable': [46], 'animal': [47, 59], 'models.': [48], 'To': [49], 'develop': [50], 'what': [51], 'we': [52, 63], 'believe': [53], 'be': [55, 72], 'first': [57], 'viable': [58], 'model': [60], 'generated': [64, 197], 'mice': [65, 102, 152, 200], 'which': [67], 'V2R': [69, 99, 138, 198], 'could': [71], 'conditionally': [73], 'deleted': [74], 'during': [75], 'adulthood': [76], 'administration': [78], '4-OH-tamoxifen.Radioligand-binding': [80], 'studies': [81], 'confirmed': [82], 'V2R-binding': [86], 'sites': [87], 'kidneys': [89], 'following': [90], '4-OH-tamoxifen': [91], 'treatment,': [92], 'and': [93, 112, 146, 203], 'further': [94], 'analysis': [95, 122], 'indicated': [96], 'upon': [98], 'deletion,': [100], 'adult': [101], 'displayed': [103], 'all': [104, 161], 'characteristic': [105], 'symptoms': [106], 'including': [109, 166], 'polyuria,': [110], 'polydipsia,': [111], 'resistance': [113], 'antidiuretic': [116], 'actions': [117], 'vasopressin.': [119], 'Gene': [120], 'expression': [121], 'suggested': [123], 'activation': [125], 'EP4': [128, 156, 182], 'PGE2': [129], 'receptors': [130, 183], 'might': [131], 'compensate': [132], 'activity': [139], 'XNDI': [141], 'mice.': [142], 'Strikingly,': [143], 'both': [144], 'acute': [145], 'chronic': [147], 'treatment': [148, 210], 'mutant': [151, 199], 'with': [153, 213], 'selective': [155], 'agonist': [158], 'greatly': [159], 'reduced': [160], 'major': [162], 'manifestations': [163], 'changes': [167], 'morphology.These': [170], 'physiological': [171], 'improvements': [172], 'were': [173], 'most': [174], 'likely': [175], 'direct': [179], 'action': [180], 'on': [181, 185], 'expressed': [184], 'collecting': [186], 'duct': [187], 'cells.': [188], 'These': [189], 'findings': [190], 'illustrate': [191], 'usefulness': [193], 'newly': [196], 'elucidating': [202], 'testing': [204], 'new': [205], 'strategies': [206], 'potential': [209], 'humans': [212], 'XNDI.': [214]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1993471526', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 9}], 'updated_date': '2024-12-14T05:47:17.671768', 'created_date': '2016-06-24'}